keyword
https://read.qxmd.com/read/38546913/genetic-variations-related-to-angiotensin-ii-production-and-risk-for-basal-cell-carcinoma
#21
REVIEW
Iphigenia Gintoni, Michael Mastrogeorgiou, Veronica Papakosta, Stavros Vassiliou, Christos Yapijakis
Basal cell carcinoma (BCC) is the most prevalent human neoplasm, with constantly increasing annual incidence. Despite its slow growth, BCC is locally invasive and, if left untreated, can cause severe complications, including metastasis and death. The renin-angiotensin system (RAS) plays a key role in electrolyte balance, atrial pressure, tissue development, homeostasis, and inflammation, but also in cancer development. After binding to its type 1 receptor (AT1R), angiotensin II (ANGII), the system's principal hormonal effector, regulates cancer pathways spanning from the formation of the initial cancer cell to the construction and nutrition of the tumor microenvironment, angiogenesis, proliferation, and metastasis...
March 28, 2024: Biochemical Genetics
https://read.qxmd.com/read/38546906/tumor-associated-fibrosis-a-unique-mechanism-promoting-ovarian-cancer-metastasis-and-peritoneal-dissemination
#22
REVIEW
Hiroki Fujimoto, Masato Yoshihara, Raymond Rodgers, Shohei Iyoshi, Kazumasa Mogi, Emiri Miyamoto, Sae Hayakawa, Maia Hayashi, Satoshi Nomura, Kazuhisa Kitami, Kaname Uno, Mai Sugiyama, Yoshihiro Koya, Yoshihiko Yamakita, Akihiro Nawa, Atsushi Enomoto, Carmela Ricciardelli, Hiroaki Kajiyama
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge...
March 28, 2024: Cancer Metastasis Reviews
https://read.qxmd.com/read/38546900/risk-factors-and-the-nomogram-model-for-malnutrition-in-patients-with-nasopharyngeal-carcinoma
#23
JOURNAL ARTICLE
Pengpeng Wang, Xueling Huang, Yuanhang Liu, Li Xue, Chuanyi Ning, Li Jiang, Jieying Liu
BACKGROUND: For patients with nasopharyngeal carcinoma (NPC), the incidence of malnutrition is quite high, and malnutrition has severe effects on NPC patients. However, there is currently no recognized gold standard or specific nutritional assessment tool available to assess malnutrition in NPC patients. Our objective was to develop and verify a new nomogram model for NPC patients. METHODS: Data were collected from NPC patients. To evaluate risk factors for malnutrition, univariate and multivariate logistic regression analyses were used...
March 28, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38546893/investigating-the-correlation-between-prominent-viruses-and-hematological-malignancies-a-literature-review
#24
REVIEW
Arian Haghtalab, Milad Hejazi, Naeem Goharnia, Ali Yekanlou, Kousha Hazhir, Asma Barghi, Zahra Bazzaz, Iman Allahverdizadeh, Ataollah GhalibafSabbaghi
Extensive research has been conducted on the correlation between viral infections and hematological cancers ever since the identification of the Rous Sarcoma Virus as a cancer-causing agent. Numerous viruses, such as the Epstein-Barr virus, hepatitis B virus, hepatitis C virus, human immunodeficiency virus, human T-lymphotropic virus 1, and severe acute respiratory syndrome-related coronavirus 2, have been identified as potential contributors to the development and progression of cancer by disrupting normal cellular processes...
March 28, 2024: Medical Oncology
https://read.qxmd.com/read/38546811/structure-based-multitargeted-docking-screening-pharmacokinetics-dft-and-dynamics-simulation-studies-reveal-mitoglitazone-as-a-potent-inhibitor-of-cellular-survival-and-stress-response-proteins-of-lung-cancer
#25
JOURNAL ARTICLE
Abdulkarim S Binshaya, Omar Saad Alkahtani, Fahad M Aldakheel, Ahmed Hjazi, Hassan H Almasoudi
Lung cancer is a disease in which lung cells grow abnormally and uncontrollably, and the cause of it is direct smoking, secondhand smoke, radon, asbestos, and certain chemicals. The worldwide leading cause of death is lung cancer, which is responsible for more than 1.8 million deaths yearly and is expected to rise to 2.2 million by 2030. The most common type of lung cancer is non-small cell lung cancer (NSCLC), which accounts for about 80% and small cell lung cancer (SCLC), which is more aggressive than NSCLC and is often diagnosed later and accounts for 20% of cases...
March 28, 2024: Medical Oncology
https://read.qxmd.com/read/38546800/aso-visual-abstract-high-community-level-social-vulnerability-is-associated-with-worse-recurrence-free-survival-following-resection-of-extremity-and-truncal-soft-tissue-sarcoma
#26
JOURNAL ARTICLE
Raymond S Traweek, Heather Lyu, Russell G Witt, Rebecca A Snyder, Elise F Nassif, David D Krijgh, Jeffrey M Smith, Gordon S Tilney, Chun Feng, Yi-Ju Chiang, Keila E Torres, Margaret J Roubaud, Christopher P Scally, Kelly K Hunt, Emily Z Keung, Alexander F Mericli, Christina L Roland
No abstract text is available yet for this article.
March 28, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38546799/aso-author-reflections-the-impact-of-dcis-on-positive-margin-rates
#27
JOURNAL ARTICLE
Hemali Chauhan, Hutan Ashrafian, Zoltan Takats, Daniel Richard Leff
No abstract text is available yet for this article.
March 28, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38546797/results-of-a-randomized-clinical-study-of-gemcitabine-plus-nab-paclitaxel-versus-gemcitabine-plus-s-1-as-neoadjuvant-chemotherapy-for-resectable-and-borderline-resectable-pancreatic-ductal-adenocarcinoma-rct-csgo-hbp-015
#28
JOURNAL ARTICLE
Daisaku Yamada, Shogo Kobayashi, Hidenori Takahashi, Yoshifumi Iwagami, Hirofumi Akita, Kei Asukai, Junzo Shimizu, Terumasa Yamada, Masahiro Tanemura, Shigekazu Yokoyama, Masanori Tsujie, Tadafumi Asaoka, Yutaka Takeda, Osakuni Morimoto, Akira Tomokuni, Yuichiro Doki, Hidetoshi Eguchi
BACKGROUND: The optimal neoadjuvant chemotherapy (NAC) regimen for patients with localized pancreatic ductal adenocarcinoma (PDAC) remains uncertain. This trial aimed to evaluate the efficacy and safety of two neoadjuvant chemotherapy (NAC) regimens, gemcitabine plus nab-paclitaxel (GA) and gemcitabine plus S-1 (GS), in patients with resectable/borderline-resectable (R/BR) PDAC. PATIENTS AND METHODS: Treatment-naïve patients with R/BR-PDAC were enrolled and randomly allocated...
March 28, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38546790/optimized-signal-of-calcifications-in-wide-angle-digital-breast-tomosynthesis-a-virtual-imaging-trial
#29
JOURNAL ARTICLE
Liesbeth Vancoillie, Lesley Cockmartin, Ferdinand Lueck, Nicholas Marshall, Machteld Keupers, Ralf Nanke, Steffen Kappler, Chantal Van Ongeval, Hilde Bosmans
OBJECTIVES: Evaluate microcalcification detectability in digital breast tomosynthesis (DBT) and synthetic 2D mammography (SM) for different acquisition setups using a virtual imaging trial (VIT) approach. MATERIALS AND METHODS: Medio-lateral oblique (MLO) DBT acquisitions on eight patients were performed at twice the automatic exposure controlled (AEC) dose. The noise was added to the projections to simulate a given dose trajectory. Virtual microcalcification models were added to a given projection set using an in-house VIT framework...
March 28, 2024: European Radiology
https://read.qxmd.com/read/38546788/publication-bias-in-upper-gastrointestinal-oncology-clinical-trials
#30
JOURNAL ARTICLE
Trenton Lippert, Erin Schmucker, Anchal Shukla, Ruha Reddy, Pooja Neerumalla, Gabriella Blanco, Vic Velanovich
PURPOSE: Evidence-based medicine requires evaluation of the medical literature to guide clinical reasoning and treatment recommendations. The presence of publication bias towards exclusion of non-statistically significant clinical trials may be leading to an incomplete evaluation of the literature and cause potentially incomplete guidance for patients. We aimed to compare publication rates and impact of publications of positive and negative outcome clinical trials. METHODS: We queried the US National Library of Medicine Clinical Trials database identifying clinical trials with reported results on the topics of pancreatic, liver, and gastric cancer...
March 28, 2024: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/38546699/the-potential-of-wearable-devices-in-cancer-care-delivery
#31
JOURNAL ARTICLE
Sarah T Hawley, Megan R Haymart
No abstract text is available yet for this article.
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546697/machine-learning-based-prediction-of-hospitalization-during-chemoradiotherapy-with-daily-step-counts
#32
JOURNAL ARTICLE
Isabel D Friesner, Jean Feng, Shalom Kalnicki, Madhur Garg, Nitin Ohri, Julian C Hong
IMPORTANCE: Toxic effects of concurrent chemoradiotherapy (CRT) can cause treatment interruptions and hospitalizations, reducing treatment efficacy and increasing health care costs. Physical activity monitoring may enable early identification of patients at high risk for hospitalization who may benefit from proactive intervention. OBJECTIVE: To develop and validate machine learning (ML) approaches based on daily step counts collected by wearable devices on prospective trials to predict hospitalizations during CRT...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546670/comment-on-the-burden-of-infection-attributable-cancers-in-the-us
#33
JOURNAL ARTICLE
Ying Zhu, Liping Zou
No abstract text is available yet for this article.
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546663/physical-activity-using-a-wearable-device-as-an-alternative-to-performance-status-in-patients-with-advanced-lung-cancer
#34
JOURNAL ARTICLE
Kentaro Ito, Yuta Suzuki, Tadashi Sakaguchi, Kentaro Fujiwara, Yoichi Nishii, Hiroki Yasui, Osamu Taguchi, Osamu Hataji
IMPORTANCE: The Eastern Cooperative Oncology Group Performance Status (ECOG PS) is extensively used to guide treatment decisions in patients with advanced lung cancer. However, its assessment is subjective, potentially leading to discordance among observers. OBJECTIVE: To investigate the association between measured physical activity and ECOG PS, as well as the potential prognostic value of physical activity measurements in patients with advanced lung cancer. DESIGN, SETTING, AND PARTICIPANTS: This single-institution, prospective observational study enrolled 119 patients with advanced lung cancer scheduled to receive systemic therapy as outpatients at Matsusaka Municipal Hospital in Mie, Japan...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546654/comment-on-the-burden-of-infection-attributable-cancers-in-the-us-reply
#35
JOURNAL ARTICLE
Karena D Volesky-Avellaneda, Mariam El-Zein, Thomas R O'Brien
No abstract text is available yet for this article.
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546643/germline-genetic-testing-and-survival-outcomes-among-children-with-rhabdomyosarcoma-a-report-from-the-children-s-oncology-group
#36
JOURNAL ARTICLE
Bailey A Martin-Giacalone, He Li, Michael E Scheurer, Dana L Casey, Shannon Dugan-Perez, Deborah A Marquez-Do, Donna Muzny, Richard A Gibbs, Donald A Barkauskas, David Hall, Douglas R Stewart, Joshua D Schiffman, Matthew T McEvoy, Javed Khan, David Malkin, Corinne M Linardic, Brian D Crompton, Jack F Shern, Stephen X Skapek, Rajkumar Venkatramani, Douglas S Hawkins, Aniko Sabo, Sharon E Plon, Philip J Lupo
IMPORTANCE: Determining the impact of germline cancer-predisposition variants (CPVs) on outcomes could inform novel approaches to testing and treating children with rhabdomyosarcoma. OBJECTIVE: To assess whether CPVs are associated with outcome among children with rhabdomyosarcoma. DESIGN, SETTING, AND PARTICIPANTS: In this cohort study, data were obtained for individuals, aged 0.01-23.23 years, newly diagnosed with rhabdomyosarcoma who were treated across 171 Children's Oncology Group sites from March 15, 1999, to December 8, 2017...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38546614/comment-on-cancers-attributable-to-infections-in-the-us
#37
JOURNAL ARTICLE
Tianyu Wang, Qian Gui, Jinghai Mao
No abstract text is available yet for this article.
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546612/tumor-intrinsic-subtypes-and-gene-expression-signatures-in-early-stage-erbb2-her2-positive-breast-cancer-a-pooled-analysis-of-calgb-40601-neoaltto-and-nsabp-b-41-trials
#38
JOURNAL ARTICLE
Aranzazu Fernandez-Martinez, Mattia Rediti, Gong Tang, Tomás Pascual, Katherine A Hoadley, David Venet, Naim U Rashid, Patricia A Spears, Md N Islam, Sarra El-Abed, Judith Bliss, Matteo Lambertini, Serena Di Cosimo, Jens Huobe, David Goerlitz, Rong Hu, Peter C Lucas, Sandra M Swain, Christos Sotiriou, Charles M Perou, Lisa A Carey
IMPORTANCE: Biologic features may affect pathologic complete response (pCR) and event-free survival (EFS) after neoadjuvant chemotherapy plus ERBB2/HER2 blockade in ERBB2/HER2-positive early breast cancer (EBC). OBJECTIVE: To define the quantitative association between pCR and EFS by intrinsic subtype and by other gene expression signatures in a pooled analysis of 3 phase 3 trials: CALGB 40601, NeoALTTO, and NSABP B-41. DESIGN, SETTING, AND PARTICIPANTS: In this retrospective pooled analysis, 1289 patients with EBC received chemotherapy plus either trastuzumab, lapatinib, or the combination, with a combined median follow-up of 5...
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546605/dog-aloisanov-helped-diagnose-my-cancer
#39
JOURNAL ARTICLE
Ron Louie
No abstract text is available yet for this article.
March 28, 2024: JAMA Oncology
https://read.qxmd.com/read/38546590/cancer-care-in-the-era-of-artificial-intelligence
#40
JOURNAL ARTICLE
Matthew Kurian, Jacob J Adashek, Howard Jack West
No abstract text is available yet for this article.
March 28, 2024: JAMA Oncology
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