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https://www.readbyqxmd.com/read/29792734/clinical-updates-on-perianal-fistulas-in-crohn-s-disease
#1
Ori Rackovsky, Robert Hirten, Ryan Ungaro, Jean-Frederic Colombel
Perianal fistulizing disease is an aggressive and debilitating phenotype of Crohn's disease (CD), representing a significant therapeutic challenge. New work has led to advancement in epidemiology and long term outcomes of perianal disease. The range of therapeutic options continues to expand, including new biologic agents, biosimilars, and stem cell therapy. Areas covered: We discuss updates to all aspects of management of perianal disease, with a focus on the last three years of published data. Areas considered include new data on epidemiology and prognostication, medical and surgical therapy, and stem cell therapy...
May 24, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29792176/anti-neutrophil-cytoplasmic-antibody-associated-glomerulonephritis-with-detection-of-myeloperoxidase-and-phospholipase-a-2-receptor-in-membranous-nephropathy-lesions-report-of-two-patients-with-microscopic-polyangiitis
#2
Kenta Tominaga, Takahiro Uchida, Toshihiko Imakiire, Kenji Itoh, Hideyuki Shimazaki, Kuniaki Nakanishi, Hiroo Kumagai, Naoki Oshima
BACKGROUND: Podocyte phospholipase A2 receptor (PLA2 R) is a major target antigen in idiopathic adult membranous nephropathy (MN). Histological PLA2 R staining in the renal tissue has proven to be useful for the detection of idiopathic MN. However, glomerular PLA2 R deposits have also been recently observed in several patients with secondary MN, such as hepatitis B virus-associated, hepatitis C virus-associated, and neoplasm-associated MN. Certain inflammatory environments have been suggested to lead to abnormal expression of PLA2 R epitopes, with the resulting production of PLA2 R autoantibodies...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29791602/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-achieving-better-agreement-by-refining-diagnostic-criteria
#3
EDITORIAL
Venancio A F Alves, Kennichi Kakudo, Virginia LiVolsi, Ricardo V Lloyd, Yuri E Nikiforov, Vania Nosé, Mauro Papotti, Lester D R Thompson
No abstract text is available yet for this article.
May 21, 2018: Clinics
https://www.readbyqxmd.com/read/29791425/-endoscopic-submucosal-dissection-of-a-transpyloric-early-gastric-c%C3%A3-ncer-a-case-report-and-literature-review
#4
Juan Antonio Chirinos Vega, César García Delgado, Alfonso Delgado Vergara
The endoscopic sumucosal disection (ESD) is an advanced endoscopic technique that achieves the curative resection of superficial neoplasms of the gastrointestinal tract, getting block exeresis with margins free of neoplasia avoiding surgery. However, tumors located in the esophagogastric junction, or pylorus, are technically more complex to resect by ESD. When a neoplasm settles in the pylorus, the anatomical characteristics of this region can affect the adequate assessment of the margins and the performance of the procedure...
January 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29791319/malignancy-in-a-retrospective-cohort-of-17-patients-with-dermatomyositis-or-polymyositis-in-southern-tunisia
#5
Khadija Sellami, Madiha Mseddi, Mouna Snoussi, Hela Gharbi, Faten Frikha, Rayda Ben Salah, Moez Jallouli, Sameh Marzouk, Abderrahmen Masmoudi, Zouhir Bahloul, Hamida Turki
INTRODUCTION: The prognosis of dermatomyositis (DM)/polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia. METHODS: A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015...
May 21, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29791169/-epicardial-fat-and-osteoprotegerin-does-a-mutual-relation-exist-pilot-study
#6
Markéta Sovová, Eliška Sovová, Jana Zapletalová, Markéta Kaletová, David Stejskal, Milan Sova, Michal Konečný, Vlastimil Procházka, Drahomíra Vrzalová, Lea Zarivnijová
INTRODUCTION: Epicardial fat (EPI) plays important role in development of metabolic and cardiovascular diseases. According to population studies EPI represents independent risk factor of cardiovascular diseases (CVD) and also for neoplasms. Osteoprotegerin (OPG) is a glycoprotein which have role in regulation of immune and cardiovascular systems. High serum levels of OPG are connected with high cardiovascular risk. The aim of our study was to evaluate possible correlation between EPI and OPG level in asymptomatic relatives of patients with CVD...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29790725/the-utilization-of-fluorescein-in-brain-tumor-surgery-a-systematic-review
#7
Claudio Cavallo, Camilla De Laurentis, Ignazio G Vetrano, Jacopo Falco, Morgan Broggi, Marco Schiariti, Paolo Ferroli, Francesco Acerbi
INTRODUCTION: Sodium Fluorescein (SF) is a green, water-soluble dye with the capacity to accumulate in cerebral areas as a result of damaged blood-brain barrier (BBB); this property allows SF to concentrate specifically at the tumor site of various types of brain neoplasms, making the tumor tissue more clearly visible. EVIDENCE ACQUISITION: A literature search (1947-2018) was conducted with the keywords "fluorescein neurosurgery", "YELLOW neurosurgery", "fluorescein brain tumor", "YELLOW brain tumor"...
May 22, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29790682/assessment-of-quality-of-life-in-patients-with-laryngeal-cancer-a-review-of-articles
#8
REVIEW
Mateusz Kolator, Patrycja Kolator, Tomasz Zatoński
This article presents a review of the medical literature published between 1994 and 2014 with the use of the PubMed database concerning quality-of-life instruments for head and neck cancer patients used to assess general well-being of patients with laryngeal cancer. The PubMed database was searched for articles containing the keywords "quality of life", "laryngeal neoplasm" and "questionnaires". The resulting articles were reviewed and analyzed. After the identification of questionnaires, an additional search was performed...
April 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790570/-%C3%A2-man-in-the-barrel%C3%A2-syndrome-atypical-manifestation-of-giant-cell-arteritis
#9
Y Calle-Lopez, A F Fernandez-Ramirez, E Franco-Dager, J G Gomez-Lopera, A L Vanegas-Garcia
INTRODUCTION: «Man-in-the-barrel» syndrome refers to diplegia of the upper extremities in which mobility of the head and lower limbs is preserved. Brachial plexitis that presents as «man-in-the-barrel» syndrome is an unusual manifestation of giant cell arteritis. We report a case of C5-C6 plexitis as part of the clinical features of a patient with giant cell arteritis. CASE REPORT: A 70-year-old male with a two-month history of weight loss, headache, facial pain and jaw claudication, associated with a persistent elevation of acute phase reactants and bilateral brachial plexopathy, with no evidence of neck or brain injuries or occult neoplasm and with negative autoimmunity tests...
June 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29790470/-hidradenocarcinoma-of-the-scrotum-with-lymph-node-metastasis
#10
Maria Inês Simões, Isabel Marcão, Mário Toscano, Luís Borges
Hidradenocarcinoma is a rare neoplasm of the eccrine cells of the sweat glands, usually asymptomatic with slow growing and higher incidence between 50 and 80 years, occurring in both sexes and preferentially located in the palmar, plantar, frontal, axillary and nuchal regions. It has an aggressive behavior, with high rate of local recurrence and distance metastasis, associated with a poor prognosis. We present a case of hidradenocarcinoma of the scrotum manifested by lymph node metastasis through an exercise of clinical and histological differential diagnosis of an inguinal adenopathy in a young adult...
March 29, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29789880/distinctive-cd8-t-cell-and-mhc-class-i-signatures-in-polycythemia-vera-patients
#11
Elsa M Cardoso, André J Esgalhado, Luís Patrão, Mónica Santos, Vasco Pinto Neves, Jorge Martinez, Maria Assunção Vaz Patto, Helena Silva, Fernando A Arosa
Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by overproduction of red blood cells. We have performed a comprehensive characterization of blood immune cells for expression of naïve and memory receptors as well as β2 m-associated and β2 m-free MHC class I heavy chains, also known as closed and open conformers, respectively, in PV patients and age-matched controls (CTR). We show that the peripheral CD3+ CD8+ T cell pool in PV patients is clearly divided into two discrete populations, a more granular CD3+ CD8high T cell population enriched in effector-memory CD45RA+ T cells (CD8+ TEMRA) when compared to CTR (P < 0...
May 22, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29789356/risk-adapted-treatment-of-acute-promyelocytic-leukemia-results-from-international-consortium-for-childhood-apl
#12
Anna Maria Testi, Andrea Pession, Daniela Diverio, David Grimwade, Brenda Gibson, Amilcar Cardoso de Azevedo, Lorena Moran, Guy Leverger, Sarah Elitzur, Henrik Hasle, Jutte van der Werff Ten Bosch, Owen Smith, Marisa De Rosa, Alfonso Piciocchi, Francesco Lo Coco, Robin Foà, Franco Locatelli, Gertjan J L Kaspers
Pediatric acute promyelocytic leukemia (APL), a rare childhood neoplasm, can be cured with all-trans retinoic acid (ATRA) and anthracycline. However, most published trials to date have employed high cumulative doses of anthracyclines. Here, we report the outcome of patients with newly diagnosed APL enrolled into the International Consortium for Childhood APL (ICC-APL-01) trial, which reduced anthracycline exposure but extended that of ATRA. The study recruited 258 children/adolescents with molecularly/cytogenetically-proven APL...
May 22, 2018: Blood
https://www.readbyqxmd.com/read/29789203/papillary-glioneuronal-tumor-a-case-report
#13
Julián Castro Castro, Olalla Lista Martínez, Nuria Caramés Díaz, Noemi Conde Lorenzo
Papillary glioneuronal tumor (PGNT) is a recently described central nervous system neoplasm. In 2007, the World Health Organization classified this tumor as a grade I neuronal-glial neoplasm. Patients are usually juvenile and young adults who commonly present with headache or seizures. We report a case of a 13-year-old boy that was related to our hospital after suffering a mild head injury result of an automobile accident. Emergent CT scan showed a right hypointense temporo-occipital lesion. MRI confirmed the presence of a lesion suggestive of a primary brain tumor...
May 19, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29789177/hematuria-as-the-only-symptom-at-initial-presentation-of-hypovolemic-shock-caused-by-ruptured-renal-arteriovenous-malformations
#14
Yi-Jui Chang, Chu-Chung Chou, Chin-Fu Chang, Yan-Ren Lin
Gross hematuria is a very common complaint in emergency departments and outpatient clinics. Globally, the incidence of hematuria is 4 per 1000 patients per year. Infection, urolithiasis, and neoplasm are the most common etiologies. However, hematuria rarely causes hypovolemic shock or an emergent, life-threatening condition at the initial presentation. In this report, we describe the case of a 64-year-old man who suffered a life-threatening gross hematuria in a very short time due to ruptured renal arteriovenous malformations (AVMs)...
May 20, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29788963/cervical-small-cell-carcinoma-frequently-presented-in-multiple-high-risk-hpv-infection-and-often-associated-with-other-type-of-epithelial-tumors
#15
Peifeng Li, Jing Ma, Xiumin Zhang, Yong Guo, Yixiong Liu, Xia Li, Danhui Zhao, Zhe Wang
BACKGROUND: Small cell carcinoma of the uterine cervix is a rare and highly malignant tumor, and its etiopathogenesis is strongly related to high-risk HPV infections. METHODS: The clinicopathological data of 30 cases of cervical primary small cell carcinoma were retrospectively analyzed. In situ hybridization, polymerase chain reaction and reverse dot-blot hybridization were employed to detect HPV DNA in both small cell carcinoma and other coexisting epithelial tumors...
May 22, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29788940/two-cases-in-which-3d-mri-was-used-to-differentiate-between-a-disc-mass-that-mimics-a-tumor-and-neurinoma
#16
Jingyu Jia, Qiangqiang Wei, Tianlong Wu, Dingwen He, Xigao Cheng
BACKGROUND: Since disc sequestration that mimics a tumor is rare and sometimes presents with an atypical appearance upon magnetic resonance imaging (MRI), it is often confused with other more common epidural and intradural neoplasms, particularly neurinoma. Open surgery is necessary due to the difficult of achieving a definitive diagnosis using computed tomography, MRI, and gadolinium- enhanced MRI prior to operation. Herein, we describe the use of coronal MR images of 3D fast-field echo with water selective excitation in the diagnosis of disc sequestration mimicking a tumor...
May 22, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29788803/establishment-of-a-spontaneously-transformed-cell-line-ju-pi-from-a-myxoinflammatory-fibroblastic-sarcoma
#17
Klaus W Fagerstedt, Tarja Salonen, Fang Zhao, Soili Kytölä, Tom Böhling, Leif C Andersson
Myxoinflammatory fibroblastic sarcoma is a soft-tissue neoplasm most frequently found in the distal extremities of middle-aged adults. Most myxoinflammatory fibroblastic sarcoma are low-grade tumors with propensity for local recurrence after incomplete removal. We report a myxoinflammatory fibroblastic sarcoma which developed in the foot of a 41-year-old male and showed an exceptionally aggressive course with metastatic spread and fatal outcome within 16 months. We managed to establish a spontaneously transformed continuous cell line, called JU-PI, from a metastatic lesion...
May 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29787942/thrombotic-and-hemorrhagic-complications-in-children-and-young-adult-recipients-of-hematopoietic-stem-cell-transplant-hsct
#18
Dominder Kaur, Aneel A Ashrani, Rajiv Pruthi, Shakila P Khan, Kent Bailey, Vilmarie Rodriguez
BACKGROUND: Overall incidence of hemostatic complications in pediatric recipients of Hematopoietic Stem Cell Transplant (HSCT) is scarcely studied. This retrospective review explored the incidence and underlying risk factors of bleeding and thrombotic complications in children. PROCEDURE: Clinical characteristics, hemorrhagic events (HE), thrombotic events (TE) and follow up data were abstracted from medical records on patients aged <21 years undergoing HSCT during January 2000-June 2015...
April 26, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29787930/fibro-osseous-pseudotumor-of-digits-expanding-the-spectrum-of-clonal-transient-neoplasms-harboring-usp6-rearrangement
#19
Uta Flucke, Sarah J Shepard, Elise M Bekers, Roberto Tirabosco, Paul J van Diest, David Creytens, Joost M van Gorp
Fibro-osseous pseudotumors of the digits (FOPD) is a rare self-limiting lesion composed of bland looking hypercellular fibrous tissue and bone. USP6 rearrangement is a consistent genetic finding in aneurysmal bone cyst, nodular fasciitis, myositis ossificans and giant cell lesions of small bones. We report herein the occurrence of USP6 rearrangement in fibro-osseous pseudotumors of the digits using fluorescence in situ hybridization analysis (FISH). Of the five patients included, three were female and two were male...
May 12, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29787881/a-long-term-follow-up-after-radiosurgery-of-papillary-tumour-of-the-pineal-region-ptpr-two-cases-report-and-review-of-the-literature
#20
Cecilia Fernández-Mateos, Roberto Martinez, Jesús Vaquero
Tumours of the pineal region are rare in adulthood, accounting for approximately 1% of intracranial neoplasms in this age range. Because of their rarity, it has proven to be difficult to establish the optimal therapy. Furthermore, microsurgical total resection in this eloquent location is associated with not low rates of morbidity. We described two patients diagnosed of papillary tumours of the pineal region (PTPR) by stereotactic biopsy and referred for gamma knife radiosurgery after shunting for hydrocephalus...
May 19, 2018: World Neurosurgery
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