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https://www.readbyqxmd.com/read/29356255/development-of-an-online-universal-utstein-registry-based-care-practice-report-card-to-improve-out-of-hospital-resuscitation-practices
#1
Valentine Baert, Joséphine Escutnaire, Ziad Nehme, Pierre Mols, Steven Lagadec, Christian Vilhelm, Line Jacob, Eric Wiel, Frédéric Adnet, Hervé Hubert
RATIONALE, AIMS AND OBJECTIVES: Care quality is a primary concern in health field. In France, the care practice report card (CPRC) is compulsory for practitioners. It is the first step towards the culture of excellence. In this context, practitioners have to assess and improve their practices. Competent authorities define registries as reliable sources for CPRC. The first aim of this work is to describe how we designed and built a universally transposable CPRC model based on an Utstein-style cardiac arrest registry...
January 22, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29356153/mun-meristem-unstructured-encoding-a-spc24-homolog-of-ndc80-kinetochore-complex-affects-development-through-cell-division-in-arabidopsis-thaliana
#2
Jinwoo Shin, Goowon Jeong, Jong-Yoon Park, Hoyeun Kim, Ilha Lee
Kinetochore, a protein super-complex on the centromere of chromosomes, mediates chromosome segregation during cell division by providing attachment sites for spindle microtubules. The NDC80 complex, composed of four proteins, NDC80, NUF2, SPC24, and SPC25, is localized at the outer kinetochore and connects spindle fibers to the kinetochore. Although it is conserved across species, functional studies of this complex are rare in Arabidopsis. Here, we characterize a recessive mutant, meristem unstructured-1 (mun-1), exhibiting an abnormal phenotype with unstructured shoot apical meristem caused by ectopic expression of the WUSCHEL gene in unexpected tissues...
January 21, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29355997/effect-of-body-mass-index-on-survival-after-sudden-cardiac-arrest
#3
Sayna Matinrazm, Adetola Ladejobi, Deepak Kumar Pasupula, Awais Javed, Asad Durrani, Shahzad Ahmad, Muhammad Bilal Munir, Evan Adelstein, Sandeep K Jain, Samir Saba
BACKGROUND: Although elevated body mass index (BMI) is a risk factor for cardiac disease, patients with elevated BMI have better survival in the context of severe illness, a phenomenon termed the "obesity paradox." HYPOTHESIS: Higher BMI is associated with lower mortality in sudden cardiac arrest (SCA) survivors. METHODS: Data were collected on 1433 post-SCA patients, discharged alive from the hospitals of the University of Pittsburgh Medical Center between 2002 and 2012...
January 22, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29355979/preoperative-coagulation-abnormalities-as-a-risk-factor-for-adverse-events-after-pancreas-surgery
#4
Joshua Castle, Aditya Mazmudar, David Bentrem
OBJECTIVE: To determine whether elevated INR or PTT values predicted 30-day postoperative adverse events following elective pancreatectomy. METHODS: The American college of surgeons national surgical quality improvement program (ACS-NSQIP) database was used to identify 14 747 patients undergoing elective pancreatectomy from 2005 to 2013. The association of elevated INR or PTT with 30-day postoperative outcomes of morbidity and mortality was examined using multivariate logistic regression analysis...
January 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29355810/successful-covered-stent-usage-for-carotid-artery-injury-with-active-medial-projecting-extravasation
#5
Nobuhiko Arai, Hiroshi Kagami, Tomohiro Funabiki, Yutaka Mine, Makoto Inaba
BACKGROUND: Non-traumatic carotid artery injury with active extravasation, or carotid blowout syndrome (CBS), is relatively rare and highly difficult to treat because it is difficult to approach the lesions due to anatomical factors. It also involves quick progression and cerebral embolization risk caused by thrombi and carotid artery occlusion. Recently, covered stents were revealed to be effective for CBS. However, they have several disadvantages, such as their costs, rebleeding complications, or cerebral embolic risks...
January 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29355751/7%C3%AE-8%C3%AE-epoxynagilactones-and-their-glucosides-from-the-twigs-of-podocarpus-nagi-isolation-structures-and-cytotoxic-activities
#6
Yuan-Dong Zheng, Gang Bai, Chunping Tang, Chang-Qiang Ke, Sheng Yao, Lin-Jiang Tong, Fang Feng, Yan Li, Jian Ding, Hua Xie, Yang Ye
A phytochemical investigation of twigs of Podocarpus nagi resulted in the identification of eight new type B nagilactones (1-8), all bearing a 7α,8α-epoxy-9(11)-enolide substructure, along with two known analogs (9-10). Their structures were determined on the basis of spectroscopic analysis, including HRESIMS, IR and NMR experiments, and X-ray crystallographic analysis. In vitro cytotoxic assay exhibited that compounds 1, 2, 9 and 10 could induce antiproliferation against three different types of human cancer cells while compounds 3 and 5 were inactive...
January 17, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29355749/discovery-of-a-highly-active-anticancer-analogue-of-cardamonin-that-acts-as-an-inducer-of-caspase-dependent-apoptosis-and-modulator-of-the-mtor-pathway
#7
Mohammed Khaled Bin Break, Md Shahadat Hossan, Yivonn Khoo, Mohannad Emad Qazzaz, Mohammed Z K Al-Hayali, Sek Chuen Chow, Christophe Wiart, Tracey D Bradshaw, Hilary Collins, Teng-Jin Khoo
Cardamonin is a natural chalcone that has been shown to exhibit high anticancer activity. In an attempt to discover analogues of cardamonin with enhanced anticancer activity, 19 analogues were synthesized and tested against A549 and HK1 cell lines. Results of the MTS cell viability assay showed that several derivatives possessed cytotoxic activities that were several-fold more potent than cardamonin. SAR analysis showed the importance of the ketone and alkene groups for bioactivity, while substituting cardamonin's phenolic groups with more polar moieties resulted in activity enhancement...
January 17, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29355698/comorbidity-and-cardiac-arrest-a-continuing-conundrum
#8
EDITORIAL
Samuel P Trethewey, Keith Couper
No abstract text is available yet for this article.
January 17, 2018: Resuscitation
https://www.readbyqxmd.com/read/29355544/quercetin-suppresses-breast-cancer-stem-cells-cd44-cd24-by-inhibiting-the-pi3k-akt-mtor-signaling-pathway
#9
Xiuli Li, Na Zhou, Jin Wang, Zhijie Liu, Xiaohui Wang, Qin Zhang, Qingyan Liu, Lifeng Gao, Rong Wang
AIMS: Cancer stem cells (CSCs) are considered the prime source of cancer recurrence, metastasis, and progression and represent important targets for developing novel anticancer agents and therapeutic strategies. The aim of this study was to investigate the effect of treating breast CSCs with the anticancer flavonoid, quercetin. MAIN METHODS: We examined changes in the cluster of differentiation CD44+/CD24-CSC population and behavior using the breast cancer cell line MCF-7...
January 16, 2018: Life Sciences
https://www.readbyqxmd.com/read/29355428/silver-fluoride-as-a-treatment-for-dental-caries
#10
J A Horst
Medical management of caries is a distinct treatment philosophy that employs topical minimally invasive therapies that treat the disease and is not merely prevention. This strategy is justified as an alternative or supplement to traditional care by significant disease recurrence rates following comprehensive operative treatment under general anesthesia. Silver diamine fluoride (SDF) is one agent to enable effective noninvasive treatment. The announcement of breakthrough therapy designation by the Food and Drug Administration (FDA) suggests that SDF may become the first FDA-approved drug for treating caries...
February 2018: Advances in Dental Research
https://www.readbyqxmd.com/read/29355424/silver-diamine-fluoride-a-successful-anticarious-solution-with-limits
#11
J O Burgess, P M Vaghela
Silver diamine fluoride (SDF) is a solution containing ionic silver, fluoride, and ammonia that arrests the progress of carious lesions and prevents the development of future caries. The silver particle extends into the dentin tubules and could create some bonding problems for subsequent composite resin restorations placed over SDF-treated darkened tooth structures. The fluoride penetrates deeper into the tooth with SDF as compared with other fluoride solutions, creating a fluoride reservoir in the tooth structure...
February 2018: Advances in Dental Research
https://www.readbyqxmd.com/read/29355301/extraordinary-interfacial-stitching-between-single-all-inorganic-perovskite-nanocrystals
#12
Leyre Gomez, Junhao Lin, Chris de Weerd, Lucas Poirier, Simon C Boehme, Elizabeth von Hauff, Yasufumi Fujiwara, Kazu Suenaga, Tom Gregorkiewicz
All-inorganic cesium lead halide perovskite nanocrystals are extensively studied because of their outstanding optoelectronic properties. Being of a cubic shape and typically featuring relatively narrow size distribution, CsPbX3 (X = Cl, Br, I) nanocrystals are the ideal starting material for the development of homogeneous thin films as required for photovoltaic and optoelectronic applications. Recent experiments reveal spontaneous merging of drop-casted CsPbBr3 nanocrystal, which is promoted by humidity and mild temperature treatments and arrested by electron beam irradiation...
January 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29354330/synthesis-biological-evaluation-and-modeling-studies-of-new-pyrido-3-4-b-indole-derivatives-as-broad-spectrum-potent-anticancer-agents
#13
Shivaputra A Patil, James K Addo, Hemantkumar Deokar, Shan Sun, Jin Wang, Wei Li, D Parker Suttle, Wei Wang, Ruiwen Zhang, John K Buolamwini
Objective: There is an urgent need drugs against particularly difficult to treat solid tumors such as pancreatic, triple negative breast, lung, colon, metastatic prostate cancers and melanoma. Thus, the objective of this study was to synthesize compounds based computational modeling that indicated the pyrido[3,4-b]indole class bind to MDM2, a new cancer target for which there are still no drug on the market. Methods: Compounds were synthesized by established methods and tested for antiproliferative activity against a broad range of human cancer cell lines, comprising HCT116 colon, HPAC, MIA PaCa-2 and Panc-1 pancreatic, MCF-7 and MDA-MB-468 breast, A375 and WM164 melanoma, A549 lung, and LNCaP, DU145 and PC3 prostate cancer lines...
March 2017: Drug Designing: Open Access
https://www.readbyqxmd.com/read/29354301/celecoxib-induces-cell-death-on-non-small-cell-lung-cancer-cells-through-endoplasmic-reticulum-stress
#14
Bomi Kim, Jayoung Kim, Yeong Seok Kim
Cyclooxygenase-2 (COX-2) is an enzyme induced by various proinflammatory and mitogenic stimuli. Celecoxib is a selective inhibitor of COX-2 that have been shown to affect cell growth and apoptosis. Lung cancer cells expressing COX-2 is able to be a target of celecoxib, this study focuses on investigating that celecoxib induces apoptosis via endoplasmic reticulum (ER) stress on lung cancer cells. We investigated whether celecoxib induced apoptosis on non-small cell lung cancer cell line, A549 and H460. The 50 µM of celecoxib increased apoptotic cells and 100 µM of celecoxib significantly induced apoptosis...
December 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29354178/the-role-of-extracorporeal-membrane-oxygenation-in-patients-after-irreversible-cardiac-arrest-as-potential-organ-donors
#15
REVIEW
Tomasz Kłosiewicz, Mateusz Puślecki, Marcin Zieliński, Michał Mandecki, Marcin Ligowski, Sebastian Stefaniak, Marek Dąbrowski, Marek Karczewski, Łukasz Gąsiorowski, Maciej Sip, Agata Dąbrowska, Wojciech Telec, Bartłomiej Perek, Marek Jemielity
The number of people waiting for a kidney or liver transplant is growing systematically. Due to the latest advances in transplantation, persons after irreversible cardiac arrest and confirmation of death have become potential organ donors. It is estimated that they may increase the number of donations by more than 40%. However, without good organization and communication between pre-hospital care providers, emergency departments, intensive care units and transplantation units, it is almost impossible to save the organs of potential donors in good condition...
December 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/29353950/a-hybrid-three-scale-model-of-tumor-growth
#16
H L Rocha, R C Almeida, E A B F Lima, A C M Resende, J T Oden, T E Yankeelov
Cancer results from a complex interplay of different biological, chemical, and physical phenomena that span a wide range of time and length scales. Computational modeling may help to unfold the role of multiple evolving factors that exist and interact in the tumor microenvironment. Understanding these complex multiscale interactions is a crucial step towards predicting cancer growth and in developing effective therapies. We integrate different modeling approaches in a multiscale, avascular, hybrid tumor growth model encompassing tissue, cell, and sub-cell scales...
January 2018: Mathematical Models & Methods in Applied Sciences: M3AS
https://www.readbyqxmd.com/read/29353904/differences-in-return-of-spontaneous-circulation-in-early-vs-late-endotracheal-intubation-among-patients-in-hospital-cardiac-arrest
#17
Battu Kumar Shrestha, Apurb Sharma, Parbesh Kumar Gyawali
BACKGROUND: Common airway management strategies during cardiopulmonary resuscitation are bag- mask-valve ventilation followed by endotracheal intubation. Timing of endotracheal intubation is controversial. This study was designed to compare the effect of early vs late endotracheal intubation in terms of return of spontaneous circulation. METHODS: This is an observational retrospective study done at tertiary center for the period of two years. The study population was inpatient, adult and pediatric with witnessed cardiac arrest in whom airway management was initially done with bag-valve-mask ventilation followed by endotracheal intubation...
January 1, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29353883/growth-arrest-and-apoptosis-induction-in-androgen-receptor-positive-human-breast-cancer-cells-by-inhibition-of-usp14-mediated-androgen-receptor-deubiquitination
#18
Yuning Liao, Xiaohong Xia, Ningning Liu, Jianyu Cai, Zhiqiang Guo, Yanling Li, Lili Jiang, Q Ping Dou, Daolin Tang, Hongbiao Huang, Jinbao Liu
It has been well known that androgen receptor (AR) is critical to prostate cancer development and progression. It has also been documented that AR is expressed in more than 60% of breast tumors, which promotes the growth of estrogen receptor-negative (ER-)/AR-positive (AR+) breast cancer cells. Thus, AR might be a potential therapeutic target for AR-positive/ER-negative breast cancer patients. Previously we reported that in prostate cancer cells proteasome-associated deubiquitinase ubiquitin-specific protease 14 (USP14) stabilized AR protein level by removing its ubiquitin chain...
January 22, 2018: Oncogene
https://www.readbyqxmd.com/read/29353819/interference-with-the-c-terminal-structure-of-marf1-causes-defective-oocyte-meiotic-division-and-female-infertility-in-mice
#19
Guang-Yi Cao, Ming-Zhe Li, Hao Wang, Lan-Ying Shi, You-Qiang Su
Meiosis-arrest female 1 (MARF1) is a recently identified key oogenic regulator essential for the maintenance of female fertility and genome integrity in mice. However, the detailed functions and the underlying mechanisms of MARF1 remain elusive. Here, in an attempt to create a mouse model expressing fluorescent protein-tagged MARF1 to facilitate further exploration of the roles of MARF1 in oocytes, we produced a Marf1-eGFP knockin (KI) mouse line in which the C-terminal structure and function of MARF1 were interfered by its fusing eGFP peptide...
January 18, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29353721/design-synthesis-and-biological-evaluation-of-novel-catecholopyrimidine-based-pde4-inhibitor-for-the-treatment-of-atopic-dermatitis
#20
Baskaran Purushothaman, Parthasarathy Arumugam, Goutam Kulsi, Joon Myong Song
Selective inhibition of phosphodiesterase (PDE) 4B favorably suppresses the synthesis of inflammatory cytokines and subsequently arrest the development of atopic dermatitis via modulating the intracellular cAMP levels. Considering the side effects of corticosteroids, selective PDE4 inhibition could constitute an effective alternative therapy for the treatment of atopic dermatitis (AD). In this study, a series of novel catechol based compounds bearing pyrimidine as the core have been synthesized and screened for the PDE4 inhibitory properties...
December 19, 2017: European Journal of Medicinal Chemistry
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