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https://www.readbyqxmd.com/read/28295771/analysis-of-17%C3%AE-estradiol-estriol-and-estrone-in-american-eel-anguilla-rostrata-tissue-samples-using-liquid-chromatography-coupled-to-electrospray-differential-ion-mobility-tandem-mass-spectrometry
#1
Alejandro Cohen, Neil W Ross, Paul M Smith, James P Fawcett
RATIONALE: 17β-Estradiol (E2), estrone (E1) and estriol (E3) are steroid hormones responsible for the regulation of the female reproductive system. Estradiol is planned to be used to feminize eels in aquaculture in order to improve their size and marketability. The residual levels of these hormones in fish tissue must be monitored to meet the requirements of food regulatory agencies. Few studies have studied these hormones on complex biological matrices such as fish tissue. METHODS: We developed a method to analyze E1, E2 and E3 in fish tissue using liquid chromatography in combination with differential ion mobility spectrometry (DMS) and tandem mass spectrometry (MS/MS)...
March 11, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28284347/novel-feedback-loop-between-m2-macrophages-microglia-and-regulatory-b-cells-in-estrogen-protected-eae-mice
#2
Gil Benedek, Jun Zhang, Ha Nguyen, Gail Kent, Hilary Seifert, Arthur A Vandenbark, Halina Offner
Immunoregulatory sex hormones, including estrogen and estriol, may prevent relapses in multiple sclerosis during pregnancy. Our previous studies have demonstrated that regulatory B cells are crucial for estrogen-mediated protection against experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of alternatively activated (M2) macrophages/microglia that results in an increased frequency of regulatory B cells in the spinal cord of estrogen treated mice with EAE...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28278220/placental-hormone-profiles-as-predictors-of-preterm-birth-in-twin-pregnancy-a-prospective-cohort-study
#3
Hui Lim, Sioned Powell, Helen C Mcnamara, A Forbes Howie, Ann Doust, Maria E Bowman, Roger Smith, Jane E Norman, Sarah J Stock
OBJECTIVE: The objective of the study was to analyse placental hormone profiles in twin pregnancies to determine if they could be used to predict preterm birth. STUDY DESIGN: Progesterone, estradiol, estriol and corticotropin-releasing hormone were measured using competitive immunoassay and radioimmunoassay in serum and saliva samples of 98 women with twin pregnancies,at 3 or more gestational timepoints. Hormone profiles throughout gestation were compared between very preterm (<34 weeks; n = 8), preterm (<37 weeks; n = 40) and term (37+ weeks; n = 50) deliveries...
2017: PloS One
https://www.readbyqxmd.com/read/28267367/systematic-indirect-comparison-of-ospemifene-versus-local-estrogens-for-vulvar-and-vaginal-atrophy
#4
N Bruyniks, N Biglia, S Palacios, A O Mueck
In the absence of a direct head-to-head study, we performed an indirect historical comparison of ospemifene 60 mg (Senshio(®)) vs. local vaginal estrogens in moderate or severe vulvar and vaginal atrophy (VVA). A literature search was carried out of clinical efficacy/safety trials of local vaginal estrogens in VVA approved in Europe. For efficacy comparison, studies had to be placebo-controlled and of 12 weeks' duration. For safety comparison, studies had to be ≥40 weeks' duration. Efficacy endpoints were the difference between active and placebo in change from baseline to week 12 for symptoms, vaginal pH, and maturation value (MV)...
March 7, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28260987/prediction-of-gestational-diabetes-mellitus-by-unconjugated-estriol-levels-in-maternal-serum
#5
Junguk Hur, Eun-Hee Cho, Kwang-Hyun Baek, Kyung Ju Lee
The aim of this study was to evaluate the association between maternal serum estriol levels, which are routinely measured in the first trimester of pregnancy, and adverse pregnancy outcomes including gestational diabetes. We performed a retrospective chart analysis of women who delivered between July 1, 2007, and December 31, 2009, at Kangnam CHA Medical Center in Seoul, Korea. Only patients with available estriol measurements during their pregnancies and complete follow-up data were included in the study. The effect of estriol on the incidence of adverse pregnancy outcomes was examined using multinomial logistic regression analysis with age and pre-pregnancy body mass index (BMI) as covariates...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28249239/simultaneous-quantification-of-estrogens-their-precursors-and-conjugated-metabolites-in-human-breast-cancer-cells-by-lc-hrms-without-derivatization
#6
Stefan Poschner, Martin Zehl, Alexandra Maier-Salamon, Walter Jäger
Liquid chromatography-mass spectrometry (LC-MS) is the state of the art technique for quantification of steroid hormones. Currently used methods are typically limited by the need of pre-column derivatization to increase ionization efficiency; however, this causes hydrolysis of conjugated metabolites. Our newly established LC-HRMS method is able to simultaneously quantify conjugated and unconjugated steroids without prior derivatization using deuterated internal standards and solid-phase extraction. This assay was validated according to ICH Q2(R1) guidelines for the analysis of the 10 main steroids of the estrogenic pathway, namely 4-androstene-3,17-dione, dehydroepiandrosterone (DHEA), DHEA-3-sulfate, estrone, 17β-estradiol, estriol (16α-OH-17β-estradiol), estrone-3-sulfate, 17β-estradiol-3-(β-d-glucuronide), 17β-estradiol-3-sulfate and testosterone...
February 22, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28247972/clinical-relevance-of-hypercoagulability-and-possible-hypofibrinolysis-associated-with-estrone-and-estriol
#7
Albe C Swanepoel, Priyaa Naidoo, Vance G Nielsen, Etheresia Pretorius
Estrone (E1 ) and Estriol (E3 ) are endogenous female hormones, present in increased concentrations during female specific physiological processes (menopause and pregnancy respectively) that are associated with increased venous thrombotic risk. These hormones are also used as hormone therapies that are also associated with increased thromboembolism risk. Viscoelastic analysis revealed no significant difference to clot formation after hormone addition, however morphological analysis showed that the addition of both E1 and E3 result in fibrin clots composed of thinner fibrin fibers arranged in dense matted networks...
March 1, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28224243/simultaneous-quantitation-of-endogenous-estrone-17%C3%AE-estradiol-and-estriol-in-human-serum-by-isotope-dilution-liquid-chromatography-tandem-mass-spectrometry-for-clinical-laboratory-applications
#8
Qiaoxuan Zhang, Liqiao Han, Jianbing Wang, Haibiao Lin, Peifeng Ke, Junhua Zhuang, Xianzhang Huang
Estrogen measurements are important in the assessment of female reproductive function and have expanding roles in other fields. A simple, accurate, highly sensitive and specific isotope-dilution liquid chromatography-tandem mass spectrometry method was developed and evaluated to simultaneously measure three endogenous estrogens in serum: estrone (E1), 17β-estradiol (E2), and estriol (E3). Chromatographic separation was achieved on a C18 column before electrospray ionization triple-quadrupole mass spectrometry in multiple reaction monitoring mode...
February 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28185621/an-alternative-perspective-of-hollow-fiber-mediated-extraction-bundled-hollow-fiber-array-liquid-phase-microextraction-with-sonication-assisted-desorption-and-liquid-chromatography-tandem-mass-spectrometry-for-determination-of-estrogens-in-aqueous-matrices
#9
Shalene Xue Lin Goh, Hian Kee Lee
A bundled hollow fiber array (BHF)-liquid-phase microextraction (LPME) approach has been developed for the ultra-high performance liquid chromatography tandem mass spectrometric determination of estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol. The BHF was dipped in n-octanol to impregnate only the wall pores of the hollow fibers without deliberate loading of extractant solvent in the lumens, before placing it in the sample for extraction. Parameters influencing extraction efficiency, such as number of bundled hollow fibers, type of extraction and desorption solvent, agitation mode, extraction temperature and duration, and the salting out effect were examined...
March 10, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28178056/first-trimester-and-second-trimester-maternal-serum-biomarkers-as-predictors-of-placental-abruption
#10
Cande V Ananth, Ronald J Wapner, Srinidhi Ananth, Mary E DʼAlton, Anthony M Vintzileos
OBJECTIVE: We hypothesized that the origins of abruption may extend to the stages of placental implantation; however, there are no reliable markers to predict its development. Based on this hypothesis, we sought to evaluate whether first-trimester and second-trimester serum analytes predict placental abruption. METHODS: We performed a secondary analysis of data of 35,307 women (250 abruption cases) enrolled in the First and Second Trimester Evaluation of Risk cohort (1999-2003), a multicenter, prospective cohort study...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28153270/in-tube-solid-phase-microextraction-based-on-nh2-mil-53-al-polymer-monolithic-column-for-online-coupling-with-high-performance-liquid-chromatography-for-directly-sensitive-analysis-of-estrogens-in-human-urine
#11
Xialin Luo, Gongke Li, Yufei Hu
In this work, a novel NH2-MIL-53(Al) incorporated poly(styrene-divinylbenzene-methacrylic acid) (poly(St-DVB-MAA)) monolith was prepared via chemical fabrication. Moreover, it has been efficiently applied to the in-tube solid-phase microextraction (SPME) for online coupling with high-performance liquid chromatography (HPLC) to the direct determination of five estrogens in human urine samples. The NH2-MIL-53(Al)-polymer monolith was suitable for in-tube SPME owing to its good permeability, high extraction efficiency, chemical stability, good reproducibility and long lifetime...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28101707/distributions-and-ecological-risk-assessment-of-estrogens-and-bisphenol-a-in-an-arid-and-semiarid-area-in-northwest-china
#12
Xiaowei Liu, Jianghong Shi, Ting Bo, Yaobin Meng, Xinmin Zhan, Mengtao Zhang, Yang Zhang
Free estrogens (estrone, E1; 17β-estradiol, 17β-E2; estriol, E3; and 17α-ethinylestradiol, EE2), their corresponding sulfate and glucuronide conjugates, and bisphenol A (BPA) were investigated in water and sediments in the Fen River catchment, an arid and semiarid area in northwest China. E1 and BPA were frequently detected in the wet and dry sampling seasons. In addition to the sulfate conjugates, other conjugated estrogens were not detected in water and sediments. The concentrations of these compounds in water generally increased from upstream to downstream...
January 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28040262/environmental-impact-of-estrogens-on-human-animal-and-plant-life-a-critical-review
#13
REVIEW
Muhammad Adeel, Xiaoming Song, Yuanyuan Wang, Dennis Francis, Yuesuo Yang
BACKGROUND: Since the inception of global industrialization, steroidal estrogens have become an emerging and serious concern. Worldwide, steroid estrogens including estrone, estradiol and estriol, pose serious threats to soil, plants, water resources and humans. Indeed, estrogens have gained notable attention in recent years, due to their rapidly increasing concentrations in soil and water all over the world. Concern has been expressed regarding the entry of estrogens into the human food chain which in turn relates to how plants take up and metabolism estrogens...
December 28, 2016: Environment International
https://www.readbyqxmd.com/read/28004439/prediction-of-fetal-growth-restriction-using-estimated-fetal-weight-versus-a-combined-screening-model-at-32-36-weeks-of-gestation
#14
Jezid Miranda, Merida Rodriguez-Lopez, Stefania Triunfo, Mikko Sairanen, Heikki Kouru, Miguel Parra-Saavedra, Francesca Crovetto, Francesc Figueras, Fatima Crispi, Eduard Gratacos
OBJECTIVES: To compare the performance of a third trimester screening based on estimated fetal weight (EFW) versus a combined model composed by maternal baseline characteristics, mean arterial pressure (MAP), ultrasound and biochemical markers for the prediction of smallness for gestational age (SGA) and late-onset fetal growth restriction (FGR). METHODS: Nested case-control study within a prospective cohort of 1,590 singleton gestations referred for third-trimester evaluation (32-36 weeks of gestation)...
December 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27987350/influence-of-beh%C3%A3-et-s-disease-on-first-and-second-trimester-serum-screening-markers
#15
Zehra Vural Yılmaz, Gülenay Gençosmanoğlu Türkmen, Elif Yılmaz, Korkut Dağlar, Ayşe Kırbaş, Cem Sanhal, Aykan Yücel, Dilek Uygur
AIM: Behçet's disease (BD) is a rare and multisystemic vasculitis disease. In this study, we investigated whether BD had any effect on the biochemical components of first and second trimester aneuploidy screening tests. METHODS: A case-control retrospective study was conducted with 32 pregnant women with BD and 60 healthy pregnant women as controls. All pregnant womens' first trimester maternal serum pregnancy-associated plasma protein-A, free β-human chorionic gonadotropin and second trimester serum alpha-fetoprotein, unconjugated estriol and total human chorionic gonadotropin levels were examined from medical records...
December 17, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27956610/neutrophils-induce-proangiogenic-t-cells-with-a-regulatory-phenotype-in-pregnancy
#16
Suchita Nadkarni, Joanne Smith, Amanda N Sferruzzi-Perri, Agata Ledwozyw, Madhav Kishore, Robert Haas, Claudio Mauro, David J Williams, Sandra H P Farsky, Federica M Marelli-Berg, Mauro Perretti
Although neutrophils are known to be fundamental in controlling innate immune responses, their role in regulating adaptive immunity is just starting to be appreciated. We report that human neutrophils exposed to pregnancy hormones progesterone and estriol promote the establishment of maternal tolerance through the induction of a population of CD4(+) T cells displaying a GARP(+)CD127(lo)FOXP3(+) phenotype following antigen activation. Neutrophil-induced T (niT) cells produce IL-10, IL-17, and VEGF and promote vessel growth in vitro...
December 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27883330/effects-of-17%C3%AE-estradiol-e2-on-aqueous-organisms-and-its-treatment-problem-a-review
#17
Emad Nazari, Fatihah Suja
Natural estrogens, estrone (E1), 17β-estradiol (E2) and estriol (E3) are endocrine disrupting chemicals (EDCs) that are discharged consistently and directly into surface waters with wastewater treatment plants (WWPTs) effluents, disposal sludges and in storm-water runoff. The most common and highest potential natural estrogen that causes estrogen activity in wastewater influent is E2. This review describes and attempts to summarize the main problems involved in the removal of E2 from WWTP by traditional processes, which fundamentally rely on activated sludge and provide an insufficient treatment for E2, as well as advanced oxidation processes (AOPs) that are applied in tertiary section treatment works...
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27848923/immunoanalytical-characteristics-of-unconjugated-estriol-indications-and-analytical-performances
#18
Camille Lefevre, Nicolas Gruchy, David Guénet, Gilles Renom, Stéphane Allouche, Marie-Hélène Read
After a short description of the structure and the physiological roles of unconjugated estriol, this paper points out pre-analytical conditions and performances of the serum unconjugated estriol immunoassay, essentially used for Down syndrome screening.
December 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27836408/effect-of-rainfall-timing-and-tillage-on-the-transport-of-steroid-hormones-in-runoff-from-manure-amended-row-crop-fields
#19
Sagor Biswas, William L Kranz, Charles A Shapiro, Daniel D Snow, Shannon L Bartelt-Hunt, Mitiku Mamo, David D Tarkalson, Tian C Zhang, David P Shelton, Simon J van Donk, Terry L Mader
Runoff generated from livestock manure amended row crop fields is one of the major pathways of hormone transport to the aquatic environment. The study determined the effects of manure handling, tillage methods, and rainfall timing on the occurrence and transport of steroid hormones in runoff from the row crop field. Stockpiled and composted manure from hormone treated and untreated animals were applied to test plots and subjected to two rainfall simulation events 30days apart. During the two rainfall simulation events, detection of any steroid hormone or metabolites was identified in 8-86% of runoff samples from any tillage and manure treatment...
February 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27776242/an-enquiry-on-appropriate-selection-of-polymers-for-preparation-of-polymeric-nanosorbents-and-nanofiltration-ultrafiltration-membranes-for-hormone-micropollutants-removal-from-water-effluents
#20
Milad Asgarpour Khansary, Mostafa Mellat, Seyed Hassan Saadat, Mahdi Fasihi-Ramandi, Mehdi Kamali, Ramezan Ali Taheri
To analyze polymeric nanosorbents and nanofiltration/ultrafiltration membranes for hormone micropollutants removal from water effluents, here an in-through investigation on the suitability and compatibility of various polymers has been carried out. For this work, estradiol, estrone, testosterone, progesterone, estriol, mestranol, and ethinylestradiol were considered. A total number of 452 polymers were analyzed and initially screened using Hansen solubility parameters. The identified good pairs of hormones and polymers then were examined to obtain the equilibrium capacity of hormones removal from water effluents using a modified Flory-Huggins model...
February 2017: Chemosphere
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