keyword
MENU ▼
Read by QxMD icon Read
search

Estriol

keyword
https://www.readbyqxmd.com/read/29146425/unprecedented-sensitivity-of-the-planar-yeast-estrogen-screen-by-using-a-spray-on-technology
#1
Andreas Schoenborn, Pascal Schmid, Sarah Bräm, Georg Reifferscheid, Marina Ohlig, Sebastian Buchinger
The planar yeast estrogen screen (p-YES) can serve as a highly valuable and sensitive screening tool for the detection of estrogenic compounds in various sample matrices such as water and wastewater, personal care products and foodstuff. The method combines the separation of sample constituents by thin layer chromatography with the direct detection of estrogenic compounds on the surface of the HPTLC-plate. The previous protocol using the immersion of a normal phase silica HPTLC-plate in a cell suspension for bio-autography resulted in blurred signals due to the accelerated diffusion of compounds on the wet surface of the HPTLC-plate...
November 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29136849/simultaneous-determination-of-three-estrogens-in-human-saliva-without-derivatization-or-liquid-liquid-extraction-for-routine-testing-via-miniaturized-solid-phase-extraction-with-lc-ms-ms-detection
#2
Xiaoguang Sunny Li, Shu Li, Gottfried Kellermann
Accurate quantitation of estrogens (i.e, estrone (E1), estradiol (E2) and estriol (E3)) is valuable for clinical assessment of human health and disease. Alterations in estrogen levels have been implicated in numerous pathological conditions. However, inadequacies in sensitivity and specificity, cumbersome sample preparation and invasive specimen collection hamper the usability of available methods for clinical applications. Herein, a simple, rapid, highly sensitive and specific LC-MS/MS method was developed and validated for the simultaneous determination of three estrogens in human saliva providing a non-invasive alternative to conventional blood samples...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29112330/facile-and-versatile-strategy-to-prepare-magnetic-molecularly-imprinted-particles-based-on-the-coassembly-of-magnetic-nanoparticles-and-amphiphilic-random-copolymers
#3
Lili Zhu, Yuhua Cao, Xinjiong Ni, Aimei You, Guangqun Cao
Magnetic molecularly imprinted polymer nanoparticles for bisphenol A were prepared by coassembling magnetic nanoparticles and amphiphilic random copolymers. Under optimized conditions, bisphenol A as template molecules, magnetic molecularly imprinted polymer particles with regular morphology, small size, good monodispersity and high content of OA-Fe3 O4 were prepared by the coassembly method using P(MMA-co-MAA) with monomer ratio of 9:1. These magnetic molecularly imprinted polymer particles could be rapidly collected by an external magnet within 1 min...
November 7, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29098334/rapid-detection-of-unconjugated-estriol-in-the-serum-via-superparamagnetic-lateral-flow-immunochromatographic-assay
#4
Ce Wang, Di Guan, Chen Chen, Shang He, Xiaoting Liu, Chengbin Wang, Huijuan Wu
Unconjugated estriol (uE3) is one of the main naturally occurring estrogens that plays an important role in growth and development of the fetus. Usually, the level of uE3 is very low in men and non-pregnant women, but in pregnant women, the level of estriol has been found to be quite high. Therefore, the combination of uE3, AFP, and hCG is now widely used for Down Syndrome screening as a triple marker. Here, we developed a superparamagnetic lateral flow immunochromatographic assay to quantitatively detect uE3...
November 2, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29092787/estradiol-metabolites-as-biomarkers-of-endometrial-cancer-prognosis-after-surgery
#5
Yannick Audet-Delage, Jean Grégoire, Patrick Caron, Véronique Turcotte, Marie Plante, Pierre Ayotte, David Simonyan, Lyne Villeneuve, Chantal Guillemette
Endometrial cancer (EC) is the most common gynecologic malignancy prevailing after menopause. Defining steroid profiles may help predict the risk of recurrence after hysterectomy, which remains limited due to the lack of reliable markers. Adrenal precursors, androgens, parent estrogens and catechol estrogen metabolites were measured by mass spectrometry (MS) in preoperative serums and those collected one month after hysterectomy from 246 newly diagnosed postmenopausal EC cases. We also examined the associations between steroid hormones and EC status by including 110 healthy postmenopausal women...
October 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29056745/sex-hormone-metabolism-and-threatened-abortion
#6
Qianhua Xu, Juan Chen, Zhaolian Wei, Theodore R Brandon, David T Zava, Yuenian Eric Shi, Yunxia Cao
BACKGROUND The aim of this study was to evaluate changes in sex hormone metabolism in patients with threatened miscarriage. MATERIAL AND METHODS We recruited 73 women in early pregnancy (6-8 weeks of gestation) and divided them into the following 2 groups based on whether they had vaginal bleeding: group A (n=34), the threatened abortion group; and group B (n=39), the normal pregnancy group. Human chorionic gonadotrophin (hCG), estradiol (E2), progesterone (P4), and testosterone (T) serum levels were tested and sex hormone metabolites in the urine were detected using gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS)...
October 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29053996/toxicological-and-chemical-insights-into-representative-source-and-drinking-water-in-eastern-china
#7
Peng Shi, Sicong Zhou, Hongxia Xiao, Jingfan Qiu, Aimin Li, Qing Zhou, Yang Pan, Henner Hollert
Drinking water safety is continuously threatened by the emergence of numerous toxic organic pollutants (TOPs) in environmental waters. In this study, an approach integrating in vitro bioassays and chemical analyses was performed to explore toxicological profiles of representative source and drinking water from waterworks of the Yangtze River (Yz), Taihu Lake (Th), and the Huaihe River (Hh) basins in eastern China. Overall, 34 of 96 TOPs were detected in all water samples, with higher concentrations in both source and drinking water samples of Hh, and pollutant profiles also differed across different river basins...
October 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29044511/second-trimester-levels-of-fetoplacental-hormones-among-women-with-placenta-accreta-spectrum-disorders
#8
Marina Pekar-Zlotin, Yaakov Melcer, Ron Maymon, Eric Jauniaux
Human chorionic gonadotropin (hCG) and its free β-subunit (β-hCG) are exclusively synthesized by the villous trophoblast. α-Fetoprotein (AFP) is synthesized by the secondary yolk sac and fetal liver. Levels of both hormones differ between women with placenta accreta spectrum (PAS) disorders and those with non-accreta previa.(1,2) Second-trimester maternal serum levels of AFP are increased,(1) and first-trimester serum β-hCG is decreased in women with PAS,(2) compared with those with non-accreta placenta previa...
October 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29032095/a-review-on-environmental-monitoring-of-water-organic-pollutants-identified-by-eu-guidelines
#9
REVIEW
João C G Sousa, Ana R Ribeiro, Marta O Barbosa, M Fernando R Pereira, Adrián M T Silva
The contamination of fresh water is a global concern. The huge impact of natural and anthropogenic organic substances that are constantly released into the environment, demands a better knowledge of the chemical status of Earth's surface water. Water quality monitoring studies have been performed targeting different substances and/or classes of substances, in different regions of the world, using different types of sampling strategies and campaigns. This review article aims to gather the available dispersed information regarding the occurrence of priority substances (PSs) and contaminants of emerging concern (CECs) that must be monitored in Europe in surface water, according to the European Union Directive 2013/39/EU and the Watch List of Decision 2015/495/EU, respectively...
October 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28973345/third-trimester-estrogens-and-maternal-breast-cancer-prospective-evidence
#10
Barbara A Cohn, Piera M Cirillo, Bill R Hopper, Pentti K Siiteri
Context: Full-term pregnancy is associated with a transient increase and life-time decrease in maternal breast cancer risk. Estrone (E1), estradiol (E2), and estriol (E3) are in high concentration during the third trimester. E1 and E2 metabolism produces carcinogenic intermediaries, and E3 metabolism does not. Objective: We tested the hypothesis that higher E3 in pregnancy is protective while higher E1 plus E2 increases risk. Design: Prospective case-cohort study (n = 620; 204 cases) nested in a 38-year follow-up of 15,528 pregnant women in the Child Health and Development Studies...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28955183/a-brief-account-of-the-discovery-of-the-fetal-placental-unit-for-estrogen-production-in-equine-and-human-pregnancies-relation-to-human-medicine
#11
REVIEW
James I Raeside
The role of steroids in human medicine is well recognized, but the major contributions made by the large domestic animals as a source of material in the discovery, isolation, and determination of the structure of the steroid hormones is less well appreciated. After a brief reminder of the early efforts to obtain a reliable source of steroids for clinical use, the narrative here is to outline one example where success was ultimately achieved for estrogen replacement therapy. Whereas knowledge of the high concentrations of estrogens in urine of pregnant women and mares dates from the late 1920s, it was not until the 1940s that the latter was shown to be a practical source...
September 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28929614/plantar-keratoderma-climatericum-successful-improvement-with-a-topical-estriol-cream
#12
Pedro Mendes-Bastos
Keratoderma climatericum affects menopausal women, and the diagnosis relies on typical clinical findings and exclusion of other potential causes of acquired keratoderma. Although its pathophysiology is still unknown, there has been speculation about its relation to hormonal dysregulation (possibly a local estrogen deficiency) since the 1930s. A female patient with long-lasting keratoderma climatericum was initially prescribed a topical 50% urea ointment and clobetasol propionate 0.05% ointment, with just a slight improvement after 2 months of daily use...
September 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28852923/total-glycosides-of-paeony-shows-neuroprotective-effects-against-semen-strychni-induced-neurotoxicity-by-recovering-secretion-of-hormones-and-improving-brain-energy-metabolism
#13
Chenzhi Hou, Ruowen Zhang, Kexia Zhang, Xiaohui Chen
In this study, we investigated the protective effect of total glycosides of paeony against Semen Strychni-induced neurotoxicity and discussed some probably mechanisms. Levels of estrone, estradiol, estriol and growth hormone in male rats' serum were determined by ELISA, levels of ATP and substances associated with energy metabolism in rats' brain were determined by HPLC and levels of progesterone was determined by a UPLC-MS/MS method. The results showed that neurotoxicity induced by Semen Strychni could cause a significant decrease (p < 0...
December 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28847137/determination-of-two-progestin-metabolites-17%C3%AE-hydroxypregnanolone-and-pregnanediol-and-different-classes-of-steroids-androgens-estrogens-corticosteroids-progestins-in-rivers-and-wastewaters-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#14
Kun Zhang, Karl Fent
A highly sensitive and robust method was developed for routine analysis of two progestin metabolites, 17α-hydroxypregnanolone (17OH-Δ5P) and pregnanediol (PD), and 31 other natural and synthetic steroids and related metabolites (estrogens, androgens, corticosteroids, progestins) in river water, as well as influents and effluents of municipal wastewater treatment plants (WWTP) using HPLC-MS/MS combined with solid-phase extraction. For the various matrixes considered, the optimized method showed satisfactory performance with recoveries of 70-120% for most of target steroids...
January 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28835965/concentrations-of-estrogen-and-progesterone-in-breast-milk-and-their-relationship-with-the-mother-s-diet
#15
Mengqing Lu, Hailong Xiao, Kelei Li, Jiajing Jiang, Kejian Wu, Duo Li
The aim of the present study was to determine the concentrations of estradiol (E2), estriol (E3) and progesterone in breast milk over different lactation periods, and to assess their relationship with the mother's diet. Ninety-six breast milk samples as well as 24-hour dietary records from 32 lactating mothers were collected on day 1 (colostrum), day 14 (transitional milk) and day 42 (mature milk) after delivery in Hangzhou, China. The concentrations of E2, E3 and progesterone differed significantly through different periods of lactation (p < 0...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28821098/physical-chemical-characteristics-and-potential-use-of-a-novel-alginate-zein-hydrogel-as-the-sorption-phase-for-polar-organic-compounds
#16
Natara D B Castilhos, Naiara M F M Sampaio, Bruno C da Silva, Izabel C Riegel-Vidotti, Marco T Grassi, Bruno J G Silva
A novel alginate based hydrogel was successfully prepared and tested for the solid phase microextraction of medium-to-high polarity compounds, when supported in a polypropylene (PP) fiber. Pure alginate when added onto the surface of the PP fiber, resulted in a significant improvement in the extraction efficiency of the analytes (except for β-estradiol). The alginate hydrogel was modified upon the incorporation of a small amount of zein, a corn protein. Interestingly, the alginate/zein-supported hydrogel was capable of successfully extracting compounds with low partition constant (Kow), such as 17-α-ethinyl estradiol, progesterone and estriol, since the initial water uptake decreased dramatically in this gel, therefore, leaving the alginate hydroxyl groups more available to interact with the polar compounds...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28763401/randomized-double-blind-placebo-controlled-clinical-trial-for-evaluating-the-efficacy-of-fractional-co2-laser-compared-with-topical-estriol-in-the-treatment-of-vaginal-atrophy-in-postmenopausal-women
#17
Vera L Cruz, Marcelo L Steiner, Luciano M Pompei, Rodolfo Strufaldi, Fernando L Afonso Fonseca, Lucila H Simardi Santiago, Tali Wajsfeld, Cesar E Fernandes
OBJECTIVE: The aim of the study was to evaluate efficacy of fractional CO2 vaginal laser treatment (Laser, L) and compare it to local estrogen therapy (Estriol, E) and the combination of both treatments (Laser + Estriol, LE) in the treatment of vulvovaginal atrophy (VVA). METHODS: A total of 45 postmenopausal women meeting inclusion criteria were randomized in L, E, or LE groups. Assessments at baseline, 8 and 20 weeks, were conducted using Vaginal Health Index (VHI), Visual Analog Scale for VVA symptoms (dyspareunia, dryness, and burning), Female Sexual Function Index, and maturation value (MV) of Meisels...
July 31, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28756761/measuring-maternal-serum-screening-markers-for-down-s-syndrome-in-plasma-collected-for-cell-free-dna-testing
#18
Geralyn M Lambert-Messerlian, Elizabeth E Eklund, Louis M Neveux, Glenn E Palomaki
Objectives To determine whether maternal plasma collected in cell-free DNA stabilizing tubes is suitable for measuring prenatal screening 'serum' markers. Methods Matched plasma and serum samples were collected from 41 second trimester and 42 first trimester non-Down's syndrome pregnancies. Second trimester samples were tested for alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin, and inhibin-A (Beckman Coulter DxI immunoassay). First trimester samples were tested for human chorionic gonadotropin and pregnancy-associated plasma protein A...
September 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28750898/the-use-of-a-unique-co-culture-model-of-fetoplacental-steroidogenesis-as-a-screening-tool-for-endocrine-disruptors-the-effects-of-neonicotinoids-on-aromatase-activity-and-hormone-production
#19
Elyse Caron-Beaudoin, Rachel Viau, Andrée-Anne Hudon-Thibeault, Cathy Vaillancourt, J Thomas Sanderson
Estrogen biosynthesis during pregnancy is dependent on the collaboration between the fetus producing the androgen precursors, and the placenta expressing the enzyme aromatase (CYP19). Disruption of estrogen production by contaminants may result in serious pregnancy outcomes. We used our recently developed in vitro co-culture model of fetoplacental steroidogenesis to screen the effects of three neonicotinoid insecticides on the catalytic activity of aromatase and the production of steroid hormones. A co-culture of H295R human adrenocortical carcinoma cells with fetal characteristics and BeWo human choriocarcinoma cells which display characteristics of the villous cytotrophoblast was exposed for 24h to various concentrations of three neonicotinoids: thiacloprid, thiamethoxam and imidacloprid...
October 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28743541/a-comparative-characterization-of-estrogens-used-in-hormone-therapy-via-estrogen-receptor-er-%C3%AE-and-%C3%AE
#20
COMPARATIVE STUDY
Meghan S Perkins, Renate Louw-du Toit, Donita Africander
Conventional hormone therapy (HT) containing estrogens such as ethinylestradiol (EE) have been associated with an increased risk of breast cancer and cardiovascular disease resulting in women seeking safer alternatives that are claimed to have fewer health risks. One such alternative gaining popularity, is custom-compounded bioidentical (b)HT formulations containing bioidentical estradiol (bE2) and estriol (bE3). However, the preparation of these custom-compounded estrogens is not regulated, and depending on the route of synthesis, steroid mixtures with differing activities may be produced...
November 2017: Journal of Steroid Biochemistry and Molecular Biology
keyword
keyword
15484
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"