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https://www.readbyqxmd.com/read/27883330/effects-of-17%C3%AE-estradiol-e2-on-aqueous-organisms-and-its-treatment-problem-a-review
#1
Emad Nazari, Fatihah Suja
Natural estrogens, estrone (E1), 17β-estradiol (E2) and estriol (E3) are endocrine disrupting chemicals (EDCs) that are discharged consistently and directly into surface waters with wastewater treatment plants (WWPTs) effluents, disposal sludges and in storm-water runoff. The most common and highest potential natural estrogen that causes estrogen activity in wastewater influent is E2. This review describes and attempts to summarize the main problems involved in the removal of E2 from WWTP by traditional processes, which fundamentally rely on activated sludge and provide an insufficient treatment for E2, as well as advanced oxidation processes (AOPs) that are applied in tertiary section treatment works...
December 1, 2016: Reviews on Environmental Health
https://www.readbyqxmd.com/read/27848923/immunoanalytical-characteristics-of-unconjugated-estriol-indications-and-analytical-performances
#2
Camille Lefevre, Nicolas Gruchy, David Guénet, Gilles Renom, Stéphane Allouche, Marie-Hélène Read
After a short description of the structure and the physiological roles of unconjugated estriol, this paper points out pre-analytical conditions and performances of the serum unconjugated estriol immunoassay, essentially used for Down syndrome screening.
December 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27836408/effect-of-rainfall-timing-and-tillage-on-the-transport-of-steroid-hormones-in-runoff-from-manure-amended-row-crop-fields
#3
Sagor Biswas, William L Kranz, Charles A Shapiro, Daniel D Snow, Shannon L Bartelt-Hunt, Mitiku Mamo, David D Tarkalson, Tian C Zhang, David P Shelton, Simon J van Donk, Terry L Mader
Runoff generated from livestock manure amended row crop fields is one of the major pathways of hormone transport to the aquatic environment. The study determined the effects of manure handling, tillage methods, and rainfall timing on the occurrence and transport of steroid hormones in runoff from the row crop field. Stockpiled and composted manure from hormone treated and untreated animals were applied to test plots and subjected to two rainfall simulation events 30days apart. During the two rainfall simulation events, detection of any steroid hormone or metabolites was identified in 8-86% of runoff samples from any tillage and manure treatment...
November 4, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27776242/an-enquiry-on-appropriate-selection-of-polymers-for-preparation-of-polymeric-nanosorbents-and-nanofiltration-ultrafiltration-membranes-for-hormone-micropollutants-removal-from-water-effluents
#4
Milad Asgarpour Khansary, Mostafa Mellat, Seyed Hassan Saadat, Mahdi Fasihi-Ramandi, Mehdi Kamali, Ramezan Ali Taheri
To analyze polymeric nanosorbents and nanofiltration/ultrafiltration membranes for hormone micropollutants removal from water effluents, here an in-through investigation on the suitability and compatibility of various polymers has been carried out. For this work, estradiol, estrone, testosterone, progesterone, estriol, mestranol, and ethinylestradiol were considered. A total number of 452 polymers were analyzed and initially screened using Hansen solubility parameters. The identified good pairs of hormones and polymers then were examined to obtain the equilibrium capacity of hormones removal from water effluents using a modified Flory-Huggins model...
October 21, 2016: Chemosphere
https://www.readbyqxmd.com/read/27771018/bedside-to-bench-to-bedside-research-estrogen-receptor-beta-ligand-as-a-candidate-neuroprotective-treatment-for-multiple-sclerosis
#5
Noriko Itoh, Roy Kim, Mavis Peng, Emma DiFilippo, Hadley Johnsonbaugh, Allan MacKenzie-Graham, Rhonda R Voskuhl
Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a "next generation estriol" treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE...
October 3, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27769425/in-situ-calibration-of-three-passive-samplers-for-the-monitoring-of-steroid-hormones-in-wastewater
#6
Alena Škodová, Roman Prokeš, Zdeněk Šimek, Branislav Vrana
In situ extraction of steroid hormones from waste water using adsorption-based integrative passive samplers represents a promising approach for their monitoring in water at ultra-trace concentrations. Three passive samplers, namely a POCIS, a Chemcatcher fitted with an Empore SDB-RPS disk, and an Empore SDB-RPS disk-based sampler with enhanced water flow, were calibrated in situ in treated municipal wastewater for the purpose of monitoring five estrogens (17-β-estradiol, 17-α-estradiol, 17-α-ethinylestradiol, estrone and estriol) at sub ng per litre concentrations...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27730359/monitoring-of-endocrine-disrupting-compounds-in-surface-water-and-sediments-of-the-three-gorges-reservoir-region-china
#7
Wenfeng Wang, Anne Wairimu Ndungu, Jun Wang
Occurrence and distribution of eight selected endocrine-disrupting compounds (EDCs), including estrone (E1), 17α-ethinylestradiol (EE2), 17α-estradiol (αE2), 17β-estradiol (βE2), estriol (E3), bisphenol A (BPA), 4-nonylphenol (NP), and 4-octylphenol (OP), were investigated in surface water and sediments of the Three Gorges Reservoir region (TGRR). The mean concentrations of E1, αE2, βE2, E3, EE2, BPA, NP, and OP were 10.3, 3.3, 3.7, 17.2, 7.8, 26.6, 10.8, and 32.3 ng L(-1) respectively in surface water and 2...
October 11, 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27706856/performance-of-a-third-trimester-combined-screening-model-for-the-prediction-of-adverse-perinatal-outcome
#8
Jezid Miranda, Stefania Triunfo, Merida Rodriguez-Lopez, Mikko Sairanen, Heikki Kouru, Miguel Parra-Saavedra, Francesca Crovetto, Francesc Figueras, Fatima Crispi, Eduard Gratacos
OBJECTIVE: To explore the potential value of a third trimester combined screening for the prediction of adverse perinatal outcome (APO) in the general population and among small-for-gestational age (SGA) neonates. METHODS: Nested case-control study within a prospective cohort of 1,590 singleton gestations referred for third-trimester evaluation (32(0) -36(6) weeks of gestation). Maternal baseline characteristics, mean arterial blood pressure, fetoplacental ultrasound and circulating biochemical markers [placental growth factor (PlGF), lipocalin-2, unconjugated estriol and inhibin A] were assessed in all women who subsequently presented an APO (n = 148) and in a control group without perinatal complications (n = 902)...
October 5, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27677392/estrogenic-compound-profiles-in-an-urbanized-industry-impacted-coastal-bay-and-potential-risk-assessment-by-pollution-indices-and-multivariative-statistical-methods
#9
Zaosheng Wang, Rui Li, Fengchang Wu, Chenglian Feng, Chun Ye, Changzhou Yan
The occurrence and distribution of target estrogenic compounds in a highly urbanized industry-impacted coastal bay were investigated, and contamination profiles were evaluated by estimating total estradiol equivalents (∑EEQs) and risk quotients (RQs). Phenolic compounds were the most abundant xenoestrogens, but seldom showed contribution to the ∑EEQs. The diethylstilbestrol (DES) and 17α-ethinylestradiol (EE2) were the major contributors followed by 17β-estradiol (E2) in comparison with a slight contribution from estrone (E1) and estriol (E3)...
September 24, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27665370/estrogenic-compound-attenuates-angiotensin-ii-induced-vascular-smooth-muscle-cell-proliferation-through-interaction-between-lkb1-and-estrogen-receptor-%C3%AE
#10
Sun Ae Kim, Kyung Young Lee, Jae-Ryong Kim, Hyoung Chul Choi
The prevalence rate of cardiovascular disease is higher for males than females, and estradiol (E2) induces AMP-activated protein kinase (AMPK) activation, which is known to regulate proliferation of VSMC. We identified the estrogenic properties of nordihydroguaiaretic acid (NDGA, a lignan phytoestrogen) that inhibit VSMC proliferation and explored the underlying mechanisms. Both the phosphorylation and expression of LKB1 were increased by NDGA. In addition, NDGA significantly attenuated angiotensin II (Ang II)-induced VSMC proliferation...
September 2016: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/27660067/estrogenic-compounds-in-tunisian-urban-sewage-treatment-plant-occurrence-removal-and-ecotoxicological-impact-of-sewage-discharge-and-sludge-disposal
#11
Dalel Belhaj, Khaled Athmouni, Bouthaina Jerbi, Monem Kallel, Habib Ayadi, John L Zhou
The occurrence, fate and ecotoxicological assessment of selected estrogenic compounds were investigated at Tunisian urban sewage treatment plant. The influents, effluents, as well as primary, secondary and dehydrated sludge, were sampled and analyzed for the target estrogens to evaluate their fate. All target compounds were detected in both sewage and sludge with mean concentrations from 0.062 to 0.993 μg L(-1) and from 11.8 to 792.9 μg kg(-1)dry weight, respectively. A wide range of removal efficiencies during the treatment processes were observed, from 6...
September 22, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27649223/using-fenton-oxidation-to-simultaneously-remove-different-estrogens-from-cow-manure
#12
Minxia Sun, Defu Xu, Yuefei Ji, Juan Liu, Wanting Ling, Shunyao Li, Mindong Chen
The presence of estrogens in livestock excrement has raised concerns about their potential negative influence on animals and the overall food cycle. This is the first investigation to simultaneously remove estrogens, including estriol (E3), bisphenol A (BPA), diethylstilbestrol (DES), estradiol (E2), and ethinyl estradiol (EE2), from cow manure using a Fenton oxidation technique. Based on the residual concentrations and removal efficiency of estrogens, the Fenton oxidation reaction conditions were optimized as follows: a H₂O₂ dosage of 2...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27622697/a-simple-model-for-estimating-the-concentrations-of-natural-estrogens-in-raw-wastewater
#13
Pniela Dotan, Alon Tal, Shai Arnon
This study provides a tool for predicting the concentrations of the natural estrogens (NEs) estrone, 17β-estradiol and estriol in raw wastewater (WW). Data characterizing the biochemical oxygen demand (BOD), NE concentrations, and discharges of raw sewage to wastewater treatment plants (WWTPs) were collected from various publications and used in the model formulation. A strong correlation was found between the log transformed BOD and the log transformed estrone load (r(2)=0.84, n=61), the log transformed 17β-estradiol load (r(2)=0...
September 9, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27599329/effect-of-topical-intranasal-therapy-on-epistaxis-frequency-in-patients-with-hereditary-hemorrhagic-telangiectasia-a-randomized-clinical-trial
#14
RANDOMIZED CONTROLLED TRIAL
Kevin J Whitehead, Nathan B Sautter, Justin P McWilliams, Murali M Chakinala, Christian A Merlo, Maribeth H Johnson, Melissa James, Eric M Everett, Marianne S Clancy, Marie E Faughnan, S Paul Oh, Scott E Olitsky, Reed E Pyeritz, James R Gossage
IMPORTANCE: Epistaxis is a major factor negatively affecting quality of life in patients with hereditary hemorrhagic telangiectasia (HHT; also known as Osler-Weber-Rendu disease). Optimal treatment for HHT-related epistaxis is uncertain. OBJECTIVE: To determine whether topical therapy with any of 3 drugs with differing mechanisms of action is effective in reducing HHT-related epistaxis. DESIGN, SETTING, AND PARTICIPANTS: The North American Study of Epistaxis in HHT was a double-blind, placebo-controlled randomized clinical trial performed at 6 HHT centers of excellence...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27567599/the-formation-and-transformation-of-hormones-in-maternal-placental-and-fetal-compartments-biological-implications
#15
Jorge R Pasqualini, Gérard S Chetrite
The fetal endocrine system constitutes the earliest system developing in fetal life and operates during all the steps of gestation. Its regulation is in part dependent on the secretion of placental and/or maternal precursors emanating across the feto-maternal interface. Human fetal and placental compartments possess all the enzymatic systems necessary to produce steroid hormones. However, their activities are different and complementary: the fetus is very active in converting acetate into cholesterol, in transforming pregnanes to androstanes, various hydroxylases, sulfotransferases, while all these transformations are absent or very limited in the placenta...
July 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27546524/efficacy-of-erbium-yag-laser-treatment-compared-to-topical-estriol-treatment-for-symptoms-of-genitourinary-syndrome-of-menopause
#16
Adrian Gaspar, Hugo Brandi, Valentin Gomez, Daniel Luque
OBJECTIVES: The objective of this prospective comparative cohort study was to establish the effectiveness and safety of Erbium:YAG (Er:YAG) laser treatment for genitourinary syndrome of menopause and to compare it with an established topical estriol treatment. METHODS: Fifty patients with genitourinary syndrome of menopause were divided into two groups. The estriol group received a treatment of 0.5 mg estriol ovules for 8 weeks and the laser group was first treated for 2 weeks with 0...
August 22, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27530061/maternal-serum-screening-markers-and-nuchal-translucency-measurements-in-in%C3%A2-vitro-fertilization-pregnancies-a-systematic-review
#17
Andrea Lanes, Tianhua Huang, Ann E Sprague, Arthur Leader, Beth Potter, Mark Walker
OBJECTIVE: To study the current literature on the association between IVF treatment and maternal serum screening marker levels and nuchal translucency thickness. DESIGN: Systematic review. SETTINGS: Not applicable. PATIENT(S): Eligible studies included those with an exposed group of pregnant women that used IVF with or without intracytoplasmic sperm injection to conceive and a control group of pregnant women who conceived spontaneously...
August 13, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27526090/determination-of-estrogenic-compounds-in-milk-and-yogurt-samples-by-hollow-fibre-liquid-phase-microextraction-gas-chromatography-triple-quadrupole-mass-spectrometry
#18
Giovanni D'Orazio, Javier Hernández-Borges, Antonio Vicente Herrera-Herrera, Salvatore Fanali, Miguel Ángel Rodríguez-Delgado
An environmentally friendly method based on hollow-fibre liquid-phase microextraction (HF-LPME) was developed for the extraction of selected estrogenic compounds (i.e. four natural sexual hormones: estrone, 17β-estradiol, 17α-estradiol and estriol; two exoestrogens: 17α-ethynylestradiol and 2-methoxyestradiol; two synthetic stilbenes: dienestrol and hexestrol; and five resorcylic acid lactones: zearalenone, α-zearalanol, β-zearalanol, α-zearalenol and β-zearalenol), from whole cow and semi-skimmed goat milk and whole natural yogurt...
October 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27510162/advanced-oxidative-processes-and-membrane-separation-for-micropollutant-removal-from-biotreated-domestic-wastewater
#19
Larissa L S Silva, Julio C S Sales, Juacyara C Campos, Daniele M Bila, Fabiana V Fonseca
The presence of micropollutants in sewage is already widely known, as well as the effects caused by natural and synthetic hormones. Thus, it is necessary to apply treatments to remove them from water systems, such as advanced oxidation processes (AOPs) and membrane separation processes, which can oxidize and remove high concentrations of organic compounds. This work investigated the removal of 17β-estradiol (E2), 17α-ethinylestradiol (EE2), and estriol (E3) from biotreated sewage. Reverse osmosis processes were conducted at three recoveries (50, 60, and 70 %)...
August 10, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27504698/charge-density-and-electrostatic-potential-study-of-16%C3%AE-17%C3%AE-estriol-and-the-binding-of-estrogen-molecules-to-the-estrogen-receptors-er%C3%AE-and-er%C3%AE
#20
Elizabeth A Zhurova, Vladimir V Zhurov, Poomani Kumaradhas, Simone Cenedese, A Alan Pinkerton
An accurate X-ray diffraction study at 20 K combined with DFT theoretical calculations has been performed for the estriol crystal with two conformationally different molecules in the asymmetric unit. The electron density has been modeled via a multipole expansion, using both experimental and theoretical structure factors, and a topological analysis has been performed. The experimental molecular geometry, hydrogen bonding, atomic charges, dipole moments, and other topological characteristics are compared with those calculated theoretically...
September 1, 2016: Journal of Physical Chemistry. B
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