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https://www.readbyqxmd.com/read/29329262/contamination-and-risk-assessment-of-estrogens-in-livestock-manure-a-case-study-in-jiangsu-province-china
#1
Pengcheng Xu, Xian Zhou, Defu Xu, Yanbing Xiang, Wanting Ling, Mindong Chen
This study investigated the occurrence and contamination risk of estrogens in livestock manure in Jiangsu Province, China. Four estrogens-estriol (E3), 17β-estradiol (17β-E2), bisphenol A (BPA), and 17α-ethinyloestradiol (EE2)-were detected in livestock manure from hens, ducks, swine, and cows. The respective mean concentrations of each estrogen found in these manures were 289.8, 334.1, 330.3, and 33.7 μg/kg for E3; 38.6, 10.9, 52.9, and 38.8 μg/kg for 17β-E2; 63.6, 48.7, 51.9, and 11.7 μg/kg for BPA; and 14...
January 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29313077/magnetic-ionic-liquids-as-versatile-extraction-phases-for-the-rapid-determination-of-estrogens-in-human-urine-by-dispersive-liquid-liquid-microextraction-coupled-with-high-performance-liquid-chromatography-diode-array-detection
#2
Josias Merib, Daniel A Spudeit, Gabriela Corazza, Eduardo Carasek, Jared L Anderson
In this study, a rapid and straightforward approach based on magnetic ionic liquids (MIL) as extraction phases and dispersive liquid-liquid microextraction (DLLME) was developed to analyze the hormones estriol, 17-β-estradiol, 17-α-ethynylestradiol, and estrone in human urine samples. This is the first report of an application of manganese-based MILs compatible with HPLC to extract compounds of biological interest from urine samples. The hydrophobic MILs trihexyltetradecylphosphonium tetrachloromanganate (II) ([P6,6,6,14+]2[MnCl42-]) and aliquat tetrachloromanganate (II) ([Aliquat+]2[MnCl42-]) were employed and the optimized extraction conditions were comprised of 5 mg of MIL ([P6,6,6,14+]2[MnCl42-]), 5 μL of methanol (MeOH) as disperser solvent, and an extraction time of 90 s at sample pH 6...
January 8, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29290395/trace-analysis-of-estrogenic-compounds-in-surface-and-groundwater-by-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-as-pyridine-3-sulfonyl-derivatives
#3
Alex Glineur, Bruno Barbera, Katherine Nott, Philippe Carbonnelle, Sébastien Ronkart, Georges Lognay, Eva Tyteca
Natural estrogens (estrone: E1, 17β-estradiol: E2, estriol: E3) and synthetic 17α-ethynylestradiol (EE2) are reported as strong endocrine disruptors even at extremely low concentrations. Therefore, the watch list from the European Commission regarding emerging aquatic pollutants recommended maximum detection limits of 0.035 ng/L for EE2 and 0.4 ng/L for E1 and E2. In this study, a UHPLC-ESI-MS/MS method allowing quantification of E1, E2, E3 and EE2 in aqueous matrices was developed. The analytes were derivatized using pyridine-3-sulfonyl chloride and a broad range of product ions were generated and their specificity was assessed by analyzing both surface and groundwater...
December 19, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29247680/changes-in-steroid-profiles-of-the-blue-mussel-mytilus-trossulus-as-a-function-of-season-stage-of-gametogenesis-sex-tissue-and-mussel-bed-depth
#4
Katarzyna Smolarz, Sandra Zabrzańska, Lucyna Konieczna, Anna Hallmann
This paper describes changes in the content of free steroid hormones e.g. testosterone (T), estradiol-17β (E2), estrone (E1) and estriol (E3) of Mytilus trossulus from the southern Baltic Sea as a function of season, stage of gametogenesis, sex, tissue (gonadal and somatic) and depth. The highest levels of T, E2, E1 and E3 were found in mussels sampled in spring and summer while the lowest levels were found in winter. This pattern was stable and was seen in both sexes and tissues in mussels from both mussel beds...
December 13, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29220342/effect-of-penetration-enhancers-on-the-percuaneous-delivery-of-hormone-replacement-actives
#5
John O Trimble, Bob Light
Transdermal compositions for hormone replacement are comprised of exogenous hormones that are biochemically similar to those produced endogenously by the ovaries or elsewhere in the body. In this work, estradiol, estriol, and testosterone were loaded in transdermal vehicles, prepared using one of three selected penetration enhancer mixtures: Vehicle 1 (olive oil and oleic acid), Vehicle 2 (isopropyl palmitate and lecithin), and Vehicle 3 (isopropyl myristate and lecithin). The influence of penetration enhancers on transdermal delivery was evaluated using Franz-type diffusion cells and Normal Human 3D Model of Epidermal Tissue...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29199129/evaluating-estrogenic-and-anti-estrogenic-effect-of-endocrine-disrupting-chemicals-edcs-by-zebrafish-danio-rerio-embryo-based-vitellogenin-1-vtg1-mrna-expression
#6
Minjie Chen, Jie Zhang, Shaochen Pang, Chang Wang, Ling Wang, Yonghua Sun, Maoyong Song, Yong Liang
By measuring the vitellogenin 1 (vtg1) expression through quantitative PCR and in situ hybridization, we used the zebrafish embryo as an in vivo model to access the estrogenic or anti-estrogenic effects of several endocrine disrupting chemicals (EDCs), such as natural estrogen 17β-estradiol (E2), estriol (E3), synthetic hormones including diethylstilbestrol (DES), 4-octyl phenol (OP), bisphenol A (BPA), tamoxifen (TMX) and 3-(2,3-dibromopropyl) isocyanurate (TBC). According to our data, the estrogenic effect of the tested chemicals was ranked as: DES>E2>E3>OP>BPA, which is consistent with various in vivo and in vitro models...
January 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29175180/efflux-transport-of-estrogen-glucuronides-by-human-mrp2-mrp3-mrp4-and-bcrp
#7
Erkka Järvinen, Feng Deng, Heidi Kidron, Moshe Finel
Estrone, estradiol and estriol are endogenous human estrogens that are rapidly conjugated with glucuronic acid in both intestinal and hepatic epithelial cells. The resulting glucuronides, estrone-3-glucuronide (E1-G), estradiol-3- and 17-glucuronides (E2-3G and E2-17G), as well as estriol-3- and 16-glucuronides (E3-3G and E3-16G) are found in human plasma and urine. Unlike E2-17G, the efflux transport of other estrogen glucuronides by human transporters has not yet been investigated comprehensively. We have studied the transport of E1-G, E2-3G, E3-3G, E3-16G and estrone-3-sulfate (E1-S), another important estrogen conjugate, using the vesicular transport assay with recombinant human MRP2, MRP3, MRP4, MDR1 and BCRP that were expressed in insect cells...
November 21, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29146425/unprecedented-sensitivity-of-the-planar-yeast-estrogen-screen-by-using-a-spray-on-technology
#8
Andreas Schoenborn, Pascal Schmid, Sarah Bräm, Georg Reifferscheid, Marina Ohlig, Sebastian Buchinger
The planar yeast estrogen screen (p-YES) can serve as a highly valuable and sensitive screening tool for the detection of estrogenic compounds in various sample matrices such as water and wastewater, personal care products and foodstuff. The method combines the separation of sample constituents by thin layer chromatography with the direct detection of estrogenic compounds on the surface of the HPTLC-plate. The previous protocol using the immersion of a normal phase silica HPTLC-plate in a cell suspension for bio-autography resulted in blurred signals due to the accelerated diffusion of compounds on the wet surface of the HPTLC-plate...
November 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29136849/simultaneous-determination-of-three-estrogens-in-human-saliva-without-derivatization-or-liquid-liquid-extraction-for-routine-testing-via-miniaturized-solid-phase-extraction-with-lc-ms-ms-detection
#9
Xiaoguang Sunny Li, Shu Li, Gottfried Kellermann
Accurate quantitation of estrogens (i.e, estrone (E1), estradiol (E2) and estriol (E3)) is valuable for clinical assessment of human health and disease. Alterations in estrogen levels have been implicated in numerous pathological conditions. However, inadequacies in sensitivity and specificity, cumbersome sample preparation and invasive specimen collection hamper the usability of available methods for clinical applications. Herein, a simple, rapid, highly sensitive and specific LC-MS/MS method was developed and validated for the simultaneous determination of three estrogens in human saliva providing a non-invasive alternative to conventional blood samples...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29112330/facile-and-versatile-strategy-to-prepare-magnetic-molecularly-imprinted-particles-based-on-the-coassembly-of-magnetic-nanoparticles-and-amphiphilic-random-copolymers
#10
Lili Zhu, Yuhua Cao, Xinjiong Ni, Aimei You, Guangqun Cao
Magnetic molecularly imprinted polymer nanoparticles for bisphenol A were prepared by coassembling magnetic nanoparticles and amphiphilic random copolymers. Under optimized conditions, bisphenol A as template molecules, magnetic molecularly imprinted polymer particles with regular morphology, small size, good monodispersity and high content of OA-Fe3 O4 were prepared by the coassembly method using P(MMA-co-MAA) with monomer ratio of 9:1. These magnetic molecularly imprinted polymer particles could be rapidly collected by an external magnet within 1 min...
November 7, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29098334/rapid-detection-of-unconjugated-estriol-in-the-serum-via-superparamagnetic-lateral-flow-immunochromatographic-assay
#11
Ce Wang, Di Guan, Chen Chen, Shang He, Xiaoting Liu, Chengbin Wang, Huijuan Wu
Unconjugated estriol (uE3) is one of the main naturally occurring estrogens that plays an important role in growth and development of the fetus. Usually, the level of uE3 is very low in men and non-pregnant women, but in pregnant women, the level of estriol has been found to be quite high. Therefore, the combination of uE3, AFP, and hCG is now widely used for Down Syndrome screening as a triple marker. Here, we developed a superparamagnetic lateral flow immunochromatographic assay to quantitatively detect uE3...
November 2, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29092787/estradiol-metabolites-as-biomarkers-of-endometrial-cancer-prognosis-after-surgery
#12
Yannick Audet-Delage, Jean Grégoire, Patrick Caron, Véronique Turcotte, Marie Plante, Pierre Ayotte, David Simonyan, Lyne Villeneuve, Chantal Guillemette
Endometrial cancer (EC) is the most common gynecologic malignancy prevailing after menopause. Defining steroid profiles may help predict the risk of recurrence after hysterectomy, which remains limited due to the lack of reliable markers. Adrenal precursors, androgens, parent estrogens and catechol estrogen metabolites were measured by mass spectrometry (MS) in preoperative serums and those collected one month after hysterectomy from 246 newly diagnosed postmenopausal EC cases. We also examined the associations between steroid hormones and EC status by including 110 healthy postmenopausal women...
October 29, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29056745/sex-hormone-metabolism-and-threatened-abortion
#13
Qianhua Xu, Juan Chen, Zhaolian Wei, Theodore R Brandon, David T Zava, Yuenian Eric Shi, Yunxia Cao
BACKGROUND The aim of this study was to evaluate changes in sex hormone metabolism in patients with threatened miscarriage. MATERIAL AND METHODS We recruited 73 women in early pregnancy (6-8 weeks of gestation) and divided them into the following 2 groups based on whether they had vaginal bleeding: group A (n=34), the threatened abortion group; and group B (n=39), the normal pregnancy group. Human chorionic gonadotrophin (hCG), estradiol (E2), progesterone (P4), and testosterone (T) serum levels were tested and sex hormone metabolites in the urine were detected using gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS)...
October 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29053996/toxicological-and-chemical-insights-into-representative-source-and-drinking-water-in-eastern-china
#14
Peng Shi, Sicong Zhou, Hongxia Xiao, Jingfan Qiu, Aimin Li, Qing Zhou, Yang Pan, Henner Hollert
Drinking water safety is continuously threatened by the emergence of numerous toxic organic pollutants (TOPs) in environmental waters. In this study, an approach integrating in vitro bioassays and chemical analyses was performed to explore toxicological profiles of representative source and drinking water from waterworks of the Yangtze River (Yz), Taihu Lake (Th), and the Huaihe River (Hh) basins in eastern China. Overall, 34 of 96 TOPs were detected in all water samples, with higher concentrations in both source and drinking water samples of Hh, and pollutant profiles also differed across different river basins...
October 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29044511/second-trimester-levels-of-fetoplacental-hormones-among-women-with-placenta-accreta-spectrum-disorders
#15
Marina Pekar-Zlotin, Yaakov Melcer, Ron Maymon, Eric Jauniaux
Human chorionic gonadotropin (hCG) and its free β-subunit (β-hCG) are exclusively synthesized by the villous trophoblast. α-Fetoprotein (AFP) is synthesized by the secondary yolk sac and fetal liver. Levels of both hormones differ between women with placenta accreta spectrum (PAS) disorders and those with non-accreta previa.(1,2) Second-trimester maternal serum levels of AFP are increased,(1) and first-trimester serum β-hCG is decreased in women with PAS,(2) compared with those with non-accreta placenta previa...
October 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29032095/a-review-on-environmental-monitoring-of-water-organic-pollutants-identified-by-eu-guidelines
#16
REVIEW
João C G Sousa, Ana R Ribeiro, Marta O Barbosa, M Fernando R Pereira, Adrián M T Silva
The contamination of fresh water is a global concern. The huge impact of natural and anthropogenic organic substances that are constantly released into the environment, demands a better knowledge of the chemical status of Earth's surface water. Water quality monitoring studies have been performed targeting different substances and/or classes of substances, in different regions of the world, using different types of sampling strategies and campaigns. This review article aims to gather the available dispersed information regarding the occurrence of priority substances (PSs) and contaminants of emerging concern (CECs) that must be monitored in Europe in surface water, according to the European Union Directive 2013/39/EU and the Watch List of Decision 2015/495/EU, respectively...
October 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28973345/third-trimester-estrogens-and-maternal-breast-cancer-prospective-evidence
#17
Barbara A Cohn, Piera M Cirillo, Bill R Hopper, Pentti K Siiteri
Context: Full-term pregnancy is associated with a transient increase and life-time decrease in maternal breast cancer risk. Estrone (E1), estradiol (E2), and estriol (E3) are in high concentration during the third trimester. E1 and E2 metabolism produces carcinogenic intermediaries, and E3 metabolism does not. Objective: We tested the hypothesis that higher E3 in pregnancy is protective while higher E1 plus E2 increases risk. Design: Prospective case-cohort study (n = 620; 204 cases) nested in a 38-year follow-up of 15,528 pregnant women in the Child Health and Development Studies...
October 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28955183/a-brief-account-of-the-discovery-of-the-fetal-placental-unit-for-estrogen-production-in-equine-and-human-pregnancies-relation-to-human-medicine
#18
REVIEW
James I Raeside
The role of steroids in human medicine is well recognized, but the major contributions made by the large domestic animals as a source of material in the discovery, isolation, and determination of the structure of the steroid hormones is less well appreciated. After a brief reminder of the early efforts to obtain a reliable source of steroids for clinical use, the narrative here is to outline one example where success was ultimately achieved for estrogen replacement therapy. Whereas knowledge of the high concentrations of estrogens in urine of pregnant women and mares dates from the late 1920s, it was not until the 1940s that the latter was shown to be a practical source...
September 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28929614/plantar-keratoderma-climatericum-successful-improvement-with-a-topical-estriol-cream
#19
Pedro Mendes-Bastos
Keratoderma climatericum affects menopausal women, and the diagnosis relies on typical clinical findings and exclusion of other potential causes of acquired keratoderma. Although its pathophysiology is still unknown, there has been speculation about its relation to hormonal dysregulation (possibly a local estrogen deficiency) since the 1930s. A female patient with long-lasting keratoderma climatericum was initially prescribed a topical 50% urea ointment and clobetasol propionate 0.05% ointment, with just a slight improvement after 2 months of daily use...
September 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28852923/total-glycosides-of-paeony-shows-neuroprotective-effects-against-semen-strychni-induced-neurotoxicity-by-recovering-secretion-of-hormones-and-improving-brain-energy-metabolism
#20
Chenzhi Hou, Ruowen Zhang, Kexia Zhang, Xiaohui Chen
In this study, we investigated the protective effect of total glycosides of paeony against Semen Strychni-induced neurotoxicity and discussed some probably mechanisms. Levels of estrone, estradiol, estriol and growth hormone in male rats' serum were determined by ELISA, levels of ATP and substances associated with energy metabolism in rats' brain were determined by HPLC and levels of progesterone was determined by a UPLC-MS/MS method. The results showed that neurotoxicity induced by Semen Strychni could cause a significant decrease (p < 0...
December 2017: Metabolic Brain Disease
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