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https://www.readbyqxmd.com/read/28929614/plantar-keratoderma-climatericum-successful-improvement-with-a-topical-estriol-cream
#1
Pedro Mendes-Bastos
Keratoderma climatericum affects menopausal women, and the diagnosis relies on typical clinical findings and exclusion of other potential causes of acquired keratoderma. Although its pathophysiology is still unknown, there has been speculation about its relation to hormonal dysregulation (possibly a local estrogen deficiency) since the 1930s. A female patient with long-lasting keratoderma climatericum was initially prescribed a topical 50% urea ointment and clobetasol propionate 0.05% ointment, with just a slight improvement after 2 months of daily use...
September 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28852923/total-glycosides-of-paeony-shows-neuroprotective-effects-against-semen-strychni-induced-neurotoxicity-by-recovering-secretion-of-hormones-and-improving-brain-energy-metabolism
#2
Chenzhi Hou, Ruowen Zhang, Kexia Zhang, Xiaohui Chen
In this study, we investigated the protective effect of total glycosides of paeony against Semen Strychni-induced neurotoxicity and discussed some probably mechanisms. Levels of estrone, estradiol, estriol and growth hormone in male rats' serum were determined by ELISA, levels of ATP and substances associated with energy metabolism in rats' brain were determined by HPLC and levels of progesterone was determined by a UPLC-MS/MS method. The results showed that neurotoxicity induced by Semen Strychni could cause a significant decrease (p < 0...
August 29, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28847137/determination-of-two-progestin-metabolites-17%C3%AE-hydroxypregnanolone-and-pregnanediol-and-different-classes-of-steroids-androgens-estrogens-corticosteroids-progestins-in-rivers-and-wastewaters-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#3
Kun Zhang, Karl Fent
A highly sensitive and robust method was developed for routine analysis of two progestin metabolites, 17α-hydroxypregnanolone (17OH-Δ5P) and pregnanediol (PD), and 31 other natural and synthetic steroids and related metabolites (estrogens, androgens, corticosteroids, progestins) in river water, as well as influents and effluents of municipal wastewater treatment plants (WWTP) using HPLC-MS/MS combined with solid-phase extraction. For the various matrixes considered, the optimized method showed satisfactory performance with recoveries of 70-120% for most of target steroids...
August 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28835965/concentrations-of-estrogen-and-progesterone-in-breast-milk-and-their-relationship-with-the-mother-s-diet
#4
Mengqing Lu, Hailong Xiao, Kelei Li, Jiajing Jiang, Kejian Wu, Duo Li
The aim of the present study was to determine the concentrations of estradiol (E2), estriol (E3) and progesterone in breast milk over different lactation periods, and to assess their relationship with the mother's diet. Ninety-six breast milk samples as well as 24-hour dietary records from 32 lactating mothers were collected on day 1 (colostrum), day 14 (transitional milk) and day 42 (mature milk) after delivery in Hangzhou, China. The concentrations of E2, E3 and progesterone differed significantly through different periods of lactation (p < 0...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28821098/physical-chemical-characteristics-and-potential-use-of-a-novel-alginate-zein-hydrogel-as-the-sorption-phase-for-polar-organic-compounds
#5
Natara D B Castilhos, Naiara M F M Sampaio, Bruno C da Silva, Izabel C Riegel-Vidotti, Marco T Grassi, Bruno J G Silva
A novel alginate based hydrogel was successfully prepared and tested for the solid phase microextraction of medium-to-high polarity compounds, when supported in a polypropylene (PP) fiber. Pure alginate when added onto the surface of the PP fiber, resulted in a significant improvement in the extraction efficiency of the analytes (except for β-estradiol). The alginate hydrogel was modified upon the incorporation of a small amount of zein, a corn protein. Interestingly, the alginate/zein-supported hydrogel was capable of successfully extracting compounds with low partition constant (Kow), such as 17-α-ethinyl estradiol, progesterone and estriol, since the initial water uptake decreased dramatically in this gel, therefore, leaving the alginate hydroxyl groups more available to interact with the polar compounds...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28763401/randomized-double-blind-placebo-controlled-clinical-trial-for-evaluating-the-efficacy-of-fractional-co2-laser-compared-with-topical-estriol-in-the-treatment-of-vaginal-atrophy-in-postmenopausal-women
#6
Vera L Cruz, Marcelo L Steiner, Luciano M Pompei, Rodolfo Strufaldi, Fernando L Afonso Fonseca, Lucila H Simardi Santiago, Tali Wajsfeld, Cesar E Fernandes
OBJECTIVE: The aim of the study was to evaluate efficacy of fractional CO2 vaginal laser treatment (Laser, L) and compare it to local estrogen therapy (Estriol, E) and the combination of both treatments (Laser + Estriol, LE) in the treatment of vulvovaginal atrophy (VVA). METHODS: A total of 45 postmenopausal women meeting inclusion criteria were randomized in L, E, or LE groups. Assessments at baseline, 8 and 20 weeks, were conducted using Vaginal Health Index (VHI), Visual Analog Scale for VVA symptoms (dyspareunia, dryness, and burning), Female Sexual Function Index, and maturation value (MV) of Meisels...
July 31, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28756761/measuring-maternal-serum-screening-markers-for-down-s-syndrome-in-plasma-collected-for-cell-free-dna-testing
#7
Geralyn M Lambert-Messerlian, Elizabeth E Eklund, Louis M Neveux, Glenn E Palomaki
Objectives To determine whether maternal plasma collected in cell-free DNA stabilizing tubes is suitable for measuring prenatal screening 'serum' markers. Methods Matched plasma and serum samples were collected from 41 second trimester and 42 first trimester non-Down's syndrome pregnancies. Second trimester samples were tested for alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin, and inhibin-A (Beckman Coulter DxI immunoassay). First trimester samples were tested for human chorionic gonadotropin and pregnancy-associated plasma protein A...
September 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28750898/the-use-of-a-unique-co-culture-model-of-fetoplacental-steroidogenesis-as-a-screening-tool-for-endocrine-disruptors-the-effects-of-neonicotinoids-on-aromatase-activity-and-hormone-production
#8
Elyse Caron-Beaudoin, Rachel Viau, Andrée-Anne Hudon-Thibeault, Cathy Vaillancourt, J Thomas Sanderson
Estrogen biosynthesis during pregnancy is dependent on the collaboration between the fetus producing the androgen precursors, and the placenta expressing the enzyme aromatase (CYP19). Disruption of estrogen production by contaminants may result in serious pregnancy outcomes. We used our recently developed in vitro co-culture model of fetoplacental steroidogenesis to screen the effects of three neonicotinoid insecticides on the catalytic activity of aromatase and the production of steroid hormones. A co-culture of H295R human adrenocortical carcinoma cells with fetal characteristics and BeWo human choriocarcinoma cells which display characteristics of the villous cytotrophoblast was exposed for 24h to various concentrations of three neonicotinoids: thiacloprid, thiamethoxam and imidacloprid...
October 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28743541/a-comparative-characterization-of-estrogens-used-in-hormone-therapy-via-estrogen-receptor-er-%C3%AE-and-%C3%AE
#9
Meghan S Perkins, Renate Louw-du Toit, Donita Africander
Conventional hormone therapy (HT) containing estrogens such as ethinylestradiol (EE) have been associated with an increased risk of breast cancer and cardiovascular disease resulting in women seeking safer alternatives that are claimed to have fewer health risks. One such alternative gaining popularity, is custom-compounded bioidentical (b)HT formulations containing bioidentical estradiol (bE2) and estriol (bE3). However, the preparation of these custom-compounded estrogens is not regulated, and depending on the route of synthesis, steroid mixtures with differing activities may be produced...
July 22, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28738637/sensitive-detection-of-estriol-hormone-in-creek-water-using-a-sensor-platform-based-on-carbon-black-and-silver-nanoparticles
#10
Paulo A Raymundo-Pereira, Anderson M Campos, Fernando C Vicentini, Bruno C Janegitz, Camila D Mendonça, Leonardo N Furini, Naiza V Boas, Marcelo L Calegaro, Carlos J L Constantino, Sergio A S Machado, Osvaldo N Oliveira
We report the electrochemical detection of estriol using carbon black nanoballs (CNB) decorated with silver nanoparticles (AgNP) as electrode material. Homogeneous, porous films on glassy carbon electrodes (GCE) were obtained, with diameters of 20 - 25nm for CNB and 5 - 6nm for AgNP. CNB/AgNP electrodes had increased conductivity and electroactive area in comparison with bare GCE and GCE/CNB, according to cyclic voltammetry and electrochemical impedance spectroscopy. The oxidation potential peak was also down shifted by 93mV, compared to the bare GC electrode...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738570/determination-of-selected-bisphenols-parabens-and-estrogens-in-human-plasma-using-lc-ms-ms
#11
Lucie Kolatorova Sosvorova, Tereza Chlupacova, Jana Vitku, Martin Vlk, Jiri Heracek, Luboslav Starka, David Saman, Marketa Simkova, Richard Hampl
In this study, a novel liquid chromatography - tandem mass spectrometry method for the simultaneous determination of bisphenols (BPA, BPS, BPF, BPAF), parabens (methyl-, ethyl-, propyl-, butyl-, benzyl-paraben) and estrogens (estrone, estradiol, estriol) in human plasma is presented. Since all analytes possess the phenolic group, dansyl chloride derivatization was applied in order to gain high sensitivity. The method was validated according to FDA guidelines, and all validation requirements were satisfactory...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28730313/derivatization-free-lc-ms-ms-method-for-estrogen-quantification-in-mouse-brain-highlights-a-local-metabolic-regulation-after-oral-versus-subcutaneous-administration
#12
Ecaterina Lozan, Svitlana Shinkaruk, Shaam Alice Al Abed, Valérie Lamothe, Mylène Potier, Aline Marighetto, Jean-Marie Schmitter, Catherine Bennetau-Pelissero, Corinne Buré
17β-Estradiol (17β-E2) is a steroid with pleiotropic actions. In addition to being a sexual hormone, it is also produced in the brain where it modulates the reproductive axis. It has been shown that 17β-E2 also acts on synaptic plasticity and plays a role in neurological pathways and in neurodegenerative diseases. Assaying this steroid in the brain is thus interesting to improve our knowledge of 17β-E2 effects in the brain. However, 17β-E2 concentration in the central nervous system has been reported to be of a few nanograms per gram wet weight (nanomolar range concentration); therefore, its quantification requires both an efficient extraction process and a sensitive detection method...
July 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28726100/microrna-in-hormonal-mechanisms-of-regulation-of-nk-cell-function
#13
S V Shirshev, I V Nekrasova, O L Gorbunova, E G Orlova, I L Maslennikova
We investigated the effect of human chorionic gonadotropin, estriol, leptin, ghrelin, and kisspeptin on the microRNA expression in separated NK cells. All of these hormones are able to effectively modulate the expression of microRNAs both stimulating and suppressing the cytotoxic potential of NK cells and thereby indirectly regulate the functions of these lymphocytes.
May 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28710632/process-for-biotransformation-of-androsta-4-ene-3-17-dione-4-ad-to-androsta-1-4-diene-3-17-dione-add
#14
Surya Prakash, Abhay Bajaj
Androsta-1,4-diene-3,17-dione (androstadienedione, ADD) is key intermediate for the organic synthesis of a variety of female sex hormones such as estrone, estradiol, estriol and other related derivatives. De novo synthesis of this molecule is not yet reported in any form of living system, i.e., microbial, plant, and animal. The structural complexities due to presence of several chiral carbon centers create significant hurdles in chemical synthesis of such molecules. Microbe-mediated biotransformation offer a highly reliable, cost-effective, and relatively non hazardous way for commercial manufacturing of steroidal key intermediates...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28707514/removal-of-estrone-17%C3%AE-estradiol-and-estriol-from-sewage-and-cow-dung-by-immobilized-novosphingobium-sp-ari-1
#15
Juan Liu, Shunyao Li, Xin Li, Yanzheng Gao, Wanting Ling
Immobilized bacterial agents (IBA) can increase the cell density and improve the environmental adaptability of bacteria, as well as reduce competition by indigenous microorganisms and enhances the biodegradation of contaminants in complex matrices. An estrogen-degrading bacterium, Novosphingobium sp. ARI-1, was immobilized in calcium alginate (CA) using an embedding method and applied to the removal of estrogens from natural sewage and cow dung. The optimum immobilization conditions were as follows: sodium alginate (SA) and CaCl2·2H2O concentrations of 5% (m/v) and 4% (m/v), respectively; a bacterial suspension to sodium alginate ratio of 1:2; and crosslinking for 6 h at 4°C...
July 14, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28693900/biodegradation-of-pharmaceuticals-and-endocrine-disruptors-with-oxygen-nitrate-manganese-iv-iron-iii-and-sulfate-as-electron-acceptors
#16
Natalie Schmidt, Declan Page, Andreas Tiehm
Biodegradation of pharmaceuticals and endocrine disrupting compounds was examined in long term batch experiments for a period of two and a half years to obtain more insight into the effects of redox conditions. A mix including lipid lowering agents (e.g. clofibric acid, gemfibrozil), analgesics (e.g. diclofenac, naproxen), beta blockers (e.g. atenolol, propranolol), X-ray contrast media (e.g. diatrizoic acid, iomeprol) as well as the antiepileptic carbamazepine and endocrine disruptors (e.g. bisphenol A, 17α-ethinylestradiol) was analyzed in batch tests in the presence of oxygen, nitrate, manganese (IV), iron (III), and sulfate...
June 27, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/28672726/resource-efficiency-analysis-for-photocatalytic-degradation-and-mineralization-of-estriol-using-tio2-nanoparticles
#17
Irwing M Ramírez-Sánchez, Shea Tuberty, Mike Hambourger, Erick R Bandala
A resource efficiency analysis was developed that evaluated photocatalyst loading and temperature inputs, and assessed hydroxyl radical (OH) production. Catalyst loading (Aeroxide(®) TiO2 P25) between 1 and 1500 mg L(-1) and temperatures between 5 and 50 °C were analyzed as input resources for OH production. After, the best experimental conditions were used to degrade and mineralize estriol (E3). The analysis showed that a low catalyst concentration lead to poor absorption of radiation and a slow reaction...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28667415/determination-of-selected-steroid-hormones-in-some-surface-water-around-animal-farms-in-cape-town-using-hplc-dad
#18
Olatunde S Olatunji, Olalekan S Fatoki, Beatrice O Opeolu, Bhekumusa J Ximba, Rumbidzai Chitongo
In this study, a method for the simultaneous determination of two steroid hormones, 17β-estradiol (E2) and estriol (E3), and a hormone mimicking polycarbonate, bisphenol-A (BPA), was developed and validated. This was thereafter used for the determination of the levels of the hormones in surface water collected around some livestock farms. The sensitivity of the method allowed the LODs and LOQs of the hormones and mimic hormone in the range 1.14-2.510 and 3.42-7.53 μg/L, respectively. The results revealed wide variability in the concentrations of E2 and E3, while BPA was not detected at any of the sampling stations...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28646728/evaluation-of-the-impact-of-vasa-previa-on-feto-placental-hormonal-synthesis-and-fetal-growth
#19
Yaakov Melcer, Ron Maymon, Marina Pekar-Zlotin, Orna Levinsohn-Tavor, Josef Tovbin, Eric Jauniaux
INTRODUCTION: A vasa previa (VP) refers to aberrant chorionic vessels which can either connect the chorionic plate to a velamentous cord (type I) or a succenturiate or accessory lobe to the main placental mass (type II). METHODS: We performed retrospective cohort study of 32 singleton pregnancies diagnosed with VP. The levels of maternal serum alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) were measured at 15-18 weeks as part of the triple test screening for Trisomy 21...
June 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28622049/the-efficacy-and-safety-of-estriol-to-treat-vulvovaginal-atrophy-in-postmenopausal-women-a-systematic-literature-review
#20
C Rueda, A M Osorio, A C Avellaneda, C E Pinzón, O I Restrepo
OBJECTIVES: To evaluate the efficacy and safety of estriol for the treatment of vulvovaginal atrophy in postmenopausal women. METHODS: A systematic literature review was performed. We searched the following electronic databases: Medline, Cochrane, Embase, Lilacs, CINHAL and Google Scholar. The studies selected included controlled clinical trials and quasi-experimental studies. Selections were made in pairs and independently, first by title and abstract and then complete texts...
August 2017: Climacteric: the Journal of the International Menopause Society
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