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https://www.readbyqxmd.com/read/29218685/patient-reported-quality-of-life-and-hip-function-after-2-stage-revision-of-chronic-periprosthetic-hip-joint-infection-a-cross-sectional-study
#1
Ninna R Poulsen, Inger Mechlenburg, Kjeld Søballe, Jeppe Lange
INTRODUCTION: Very limited information is available regarding patient-reported health-related quality of life (HRQoL) and hip function following treatment for chronic periprosthetic hip joint infection (PJI). Patient-reported outcome measures provide essential information to clinicians of the impact a treatment have on patient's lives. The purpose of this study was to examine patient reported HRQoL and hip function after a completed re-implantation in a 2-stage revision. METHOD: 82 patients were identified retrospectively in the National Patient Register...
December 4, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29217449/role-of-brachial-artery-ligation-bal-in-management-of-prosthetic-arterio-venous-graft-infections
#2
A R Chandrashekar, Chetan R Hoskatti, Sanjay C Desai, Rajendra B Prasad
CONTEXT: Arterio-Venous Graft (AVG) infections can present as major life-threatening hemorrhage or sepsis in a chronic kidney disease patient. Frequently all these patients present in critical condition which need prompt and expeditious management. Various procedures are described for management of infected grafts and its bleeding complications. However these procedures are associated with postop-operative bleeding and persistent infection. AIM: To study brachial artery ligation near the elbow joint in the management of an infected AV graft...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29216405/the-human-immunodeficiency-virus-care-continuum-in-china-1985-2015
#3
Ye Ma, Zhihui Dou, Wei Guo, Yurong Mao, Fujie Zhang, Jennifer M McGoogan, Yan Zhao, Decai Zhao, Yasong Wu, Zhongfu Liu, Zunyou Wu
Background: Human immunodeficiency virus (HIV) care continuum attrition is a major global public health challenge. Few studies have examined this problem in resource-limited settings. We aimed to assess cumulative, current, and historical achievement along China's HIV continuum of care. Methods: A nationwide, serial cross-sectional study of all individuals with HIV infection diagnosed in China between 1 January 1985 and 31 December 2015 was conducted using data from China's HIV/AIDS information systems...
December 5, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29215382/initial-treatment-in-septic-arthritis-medical-versus-surgical-approach-an-8-year-single-center-in-spain-experience
#4
Bryan Josué Flores-Robles, Mercedes Jiménez Palop, Abel Alejandro Sanabria Sanchinel, Robert Francis Andrus, Ana Royuela Vicente, Marta Isabel Sanz Pérez, María Espinosa Malpartida, Consuelo Ramos Giráldez, Carolina Merino Argumanez, Luis Fernando Villa Alcázar, José Luis Andréu Sánchez, Hildegarda Godoy Tundidor, José Campos Esteban, Jesús Sanz Sanz, Carmen Barbadillo Mateos, Carlos Isasi Zaragoza, Juan Mulero Mendoza
OBJECTIVE: The aim of this study was to compare the functional results of 2 different procedure types, medical or surgical, which are used in treating native joint septic arthritis. METHODS: In this retrospective cohort study, we reviewed clinical registries of patients admitted to a single third-level hospital with the diagnosis of septic arthritis during the period of January 1, 2008, to January 31, 2016. RESULTS: A total of 63 cases of septic arthritis were identified in which the initial approach for 49 patients was medical (arthrocentesis), whereas the initial approach for 14 patients was surgical (arthroscopy or arthrotomy)...
December 5, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29212726/rapid-evolution-rescues-hosts-from-competition-and-disease-but-despite-a-dilution-effect-increases-the-density-of-infected-hosts
#5
Alexander T Strauss, Jessica L Hite, Marta S Shocket, Carla E Cáceres, Meghan A Duffy, Spencer R Hall
Virulent parasites can depress the densities of their hosts. Taxa that reduce disease via dilution effects might alleviate this burden. However, 'diluter' taxa can also depress host densities through competition for shared resources. The combination of disease and interspecific competition could even drive hosts extinct. Then again, genetically variable host populations can evolve in response to both competitors and parasites. Can rapid evolution rescue host density from the harm caused by these ecological enemies? How might such evolution influence dilution effects or the size of epidemics? In a mesocosm experiment with planktonic hosts, we illustrate the joint harm of competition and disease: hosts with constrained evolutionary ability (limited phenotypic variation) suffered greatly from both...
December 6, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29212693/clinical-functional-and-radiological-outcomes-of-extracorporeal-irradiation-in-limb-salvage-surgery-for-bone-tumours
#6
C W Jones, J Shatrov, J M Jagiello, S Millington, A Hong, R Boyle, P D Stalley
AIMS: We present a retrospective review of patients treated with extracorporeally irradiated allografts for primary and secondary bone tumours with the mid- and long-term survivorship and the functional and radiographic outcomes. PATIENTS AND METHODS: A total of 113 of 116 (97.4%) patients who were treated with extracorporeally irradiated allografts between 1996 and 2014 were followed up. Forms of treatment included reconstructions, prostheses and composite reconstructions, both with and without vascularised grafts...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212689/minimally-invasive-surgery-for-adolescent-idiopathic-scoliosis-correction-of-deformity-and-peri-operative-morbidity-in-70-consecutive-patients
#7
C de Bodman, F Miyanji, B Borner, P-Y Zambelli, G Racloz, R Dayer
AIMS: The aim of this study was to report a retrospective, consecutive series of patients with adolescent idiopathic scoliosis (AIS) who were treated with posterior minimally invasive surgery (MIS) with a mean follow-up of two years (sd 1.4; 0.9 to 0 3.7). Our objectives were to measure the correction of the deformity and record the peri-operative morbidity. Special attention was paid to the operating time (ORT), estimated blood loss (EBL), length of stay (LOS) and further complications...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212683/-hot-joints-infection-protocol-reduces-unnecessary-post-operative-re-admissions-following-total-hip-and-knee-arthroplasty
#8
J Dattilo, D Gittings, M Sloan, R Charette, E Hume, G-C Lee
AIMS: To evaluate the effectiveness of an institutionally developed algorithm for evaluation and diagnosis of prosthetic joint injection and to determine the impact of this protocol on overall hospital re-admissions.p PATIENTS AND METHODS: We retrospectively evaluated 2685 total hip arthroplasty (THA) and total knee arthroplasty (TKA) patients prior to (1263) and following (1422) the introduction of an infection detection protocol. The protocol used conservative thresholds for C-reactive protein to direct the medical attendant to aspirate the joint...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29212681/ten-year-follow-up-study-of-three-alternative-bearing-surfaces-used-in-total-hip-arthroplasty-in-young-patients-a-prospective-randomised-controlled-trial
#9
A Atrey, S E Ward, A Khoshbin, N Hussain, E Bogoch, E H Schemitsch, J P Waddell
AIMS: We present the ten-year data of a cohort of patients, aged between 18 and 65 years (mean age 52.7 years; 19 to 64), who underwent total hip arthroplasty. Patients were randomised to be treated with a cobalt-chrome (CoCr) femoral head with an ultra-high molecular weight polyethylene (UHMWPE), highly cross-linked polyethylene (XLPE) or ceramic-on-ceramic (CoC) bearing surface. PATIENTS AND METHODS: A total of 102 hips (91 patients) were randomised into the three groups...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29210159/safety-of-mtor-inhibitor-continuation-in-pediatric-heart-transplant-recipients-undergoing-surgical-procedures
#10
Ann Heble, Melanie D Everitt, Jane Gralla, Shelley D Miyamoto, Michael Lahart, Jennifer Eshelman
mTOR inhibitors have been associated with SWC when used in the perioperative period. Limited literature is available to guide providers in managing chronic mTOR inhibitor use in the perioperative period, especially in the pediatric setting. The primary aim of this study was to describe the prevalence of SWC with mTOR inhibitor continuation during the perioperative period for major surgeries. Heart transplant recipients ≤25 years old at the time of primary heart transplant receiving sirolimus maintenance therapy during a surgical procedure and within the study period were included...
December 6, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29209946/usability-and-patient-preference-phase-3-study-of-the-sarilumab-pen-in-patients-with-active-moderate-to-severe-rheumatoid-arthritis
#11
Alan Kivitz, Lydie Baret-Cormel, Hubert van Hoogstraten, Sheldon Wang, Janie Parrino, Christine Xu, Marina Stanislav
INTRODUCTION: Sarilumab is a human monoclonal antibody that blocks the interleukin-6 receptor alpha (IL-6Rα). The phase 3 SARIL-RA-EASY study (EASY) assessed the robustness of an autoinjector (pen) for administering sarilumab when used by adults with active moderate-to-severe rheumatoid arthritis (RA) who are candidates for anti-IL-6R therapy in an unsupervised real-world setting. METHODS: EASY was a 12-week, multicenter, randomized, open-label, parallel-group usability study of the sarilumab pen and prefilled syringe...
December 5, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29206802/another-option-in-the-armamentarium-understanding-the-role-of-irrigation-and-debridement-to-treat-hip-periprosthetic-joint-infection-commentary-on-an-article-by-andrew-j-bryan-md-et-al-irrigation-and-debridement-with-component-retention-for-acute-infection
#12
https://www.readbyqxmd.com/read/29206791/irrigation-and-debridement-with-component-retention-for-acute-infection-after-hip-arthroplasty-improved-results-with-contemporary-management
#13
Andrew J Bryan, Matthew P Abdel, Thomas L Sanders, Steven F Fitzgerald, Arlen D Hanssen, Daniel J Berry
BACKGROUND: There are conflicting data on the results of irrigation and debridement with component retention in patients with acute periprosthetic hip infections. The goals of this study were to examine contemporary results of irrigation and debridement with component retention for acute infection after primary hip arthroplasty and to identify host, organism, antibiotic, or implant factors that predict success or failure. METHODS: Ninety hips (57 total hip arthroplasties and 33 hemiarthroplasties) were diagnosed with acute periprosthetic hip infection (using strict criteria) and were treated with irrigation and debridement and component retention between 2000 and 2012...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29206628/implementation-gaps-for-asthma-prevention-and-control
#14
REVIEW
Luciana K Tanno, Tari Haahtela, Moises A Calderon, Alvaro Cruz, Pascal Demoly
Asthma and allergic diseases can start in childhood and persist throughout life, but could also be manifested later, at any time for still misunderstood reasons. They are major chronic multifactorial respiratory diseases, for which prevention, early diagnosis and treatment is recognized as a priority for the Europe's public health policy and the United Nations. Given that allergy triggers (including infections, rapid urbanization leading to loss in biodiversity, pollution and climate changes) are not expected to change in a foreseeable future, it is imperative that steps are taken to develop, strengthen and optimize preventive and treatment strategies...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29204500/intraoperative-chlorhexidine-irrigation-to-prevent-infection-in-total-hip-and-knee-arthroplasty
#15
Nicholas B Frisch, Omar M Kadri, Troy Tenbrunsel, Abraham Abdul-Hak, Mossub Qatu, Jason J Davis
Background: Surgical site irrigation during total hip (THA) and total knee (TKA) arthroplasty is a routine practice among orthopaedic surgeons to prevent periprosthetic joint infection. The purpose of this study was to evaluate the effect of chlorhexidine gluconate (CHG) irrigation on infection rates following THA and TKA. Methods: Arthroplasties performed before September 2014 served as controls. THA performed before September 2014 (N = 253) underwent intraoperative irrigation with 0...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29204384/approach-to-a-child-with-primary-immunodeficiency-made-simple
#16
REVIEW
Dhrubajyoti Sharma, Ankur K Jindal, Amit Rawat, Surjit Singh
Primary immunodeficiency disorders (PIDs) are a group of disorders affecting the capability to fight against infection. These include defects in T cells and B cells affecting cell-mediated and humoral immunity, respectively, combined humoral and cell-mediated immunodeficiency, defects in phagocytosis, complement defects, and defects in cytokine or cytokine signalling pathways which are detrimental for immune function. Depending upon the type and severity, age at onset of symptoms can vary from neonatal period to late childhood...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29203432/propionibacterium-acnes-prosthetic-joint-infection-diagnosis-and-treatment
#17
REVIEW
P Boisrenoult
Propionibacterium acnes is a commensal skin bacterium, regularly implicated in prosthetic joint infection, particularly of the shoulder. Diagnosis has been improved by progress in bacteriological techniques: longer culture time, liquid medium culture, MALDI-TOF mass spectrography, and universal 16S rRNA PCR, associated by some authors to sonication of ablated implants. P. acnes pathogenicity involves many virulence factors, notably including biofilm formation. P. acnes may lead to infection that is clinically evident or, frequently, relatively asymptomatic...
December 1, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29203304/post-chikungunya-chronic-inflammatory-rheumatism-follow-up-of-cases-after-1-year-of-infection-in-tolima-colombia
#18
Mónika Patricia Consuegra-Rodríguez, Diana Meliza Hidalgo-Zambrano, Heriberto Vásquez-Serna, Carlos E Jimenez-Canizales, Esteban Parra-Valencia, Alfonso J Rodriguez-Morales
INTRODUCTION: Chronic Inflammatory Rheumatism (CIR) is one of the recognized and increasingly reported consequence post-chikungunya infection (pCHIK) in Colombia and Latin America. METHODS: Retrospective cohort study of 128 patients with CHIK that persisted with pCHIK-CIR after 59-68 weeks (1.13-1.31 years). This information was evaluated by means of a telephone survey and according to validated criteria (WHO 2015) previously (patients with >12 weeks post-CHIK with ≥1 manifestations [continuous/recurrent]: chronic polyarthralgia [pCHIK-CPA], stiffness and/or joint edema)...
December 1, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29203260/the-helsinki-face-transplantation-surgical-aspects-and-1-year-outcome
#19
Patrik Lassus, Andrew Lindford, Jyrki Vuola, Leif Bäck, Sinikka Suominen, Karri Mesimäki, Tommy Wilkman, Tuija Ylä-Kotola, Erkki Tukiainen, Hannu Kuokkanen, Jyrki Törnwall
BACKGROUND: Since 2005, at least 38 facial transplantations have been performed worldwide. We herein describe the surgical technique and 1-year clinical outcome in Finland's first face transplant case. METHODS: A 34-year-old male who had a severe facial deformity following ballistic trauma in 1999 underwent facial transplantation at the Helsinki University Hospital on 8th February 2016. Three-dimensional (3D) technology was used to manufacture donor and recipient patient-specific osteotomy guides and a donor face mask...
November 15, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29202874/sensitive-detection-of-hiv-1-resistance-to-zidovudine-and-impact-on-treatment-outcomes-in-low-to-middle-income-countries
#20
Richard M Gibson, Gabrielle Nickel, Michael Crawford, Fred Kyeyune, Colin Venner, Immaculate Nankya, Eva Nabulime, Emmanuel Ndashimye, Art F Y Poon, Robert A Salata, Cissy Kityo, Peter Mugyenyi, Miguel E Quiñones-Mateu, Eric J Arts
BACKGROUND: Thymidine analogs, namely AZT (Zidovudine or Retrovir™) and d4T (Stavudine or Zerit™) are antiretroviral drugs still employed in over 75% of first line combination antiretroviral therapy (cART) in Kampala, Uganda despite aversion to prescribing these drugs for cART in high income countries due in part to adverse events. For this study, we explored how the continued use of these thymidine analogs in cART could impact emergence of drug resistance and impact on future treatment success in Uganda, a low-income country...
December 4, 2017: Infectious Diseases of Poverty
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