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https://www.readbyqxmd.com/read/28434154/protective-effects-of-cell-free-supernatant-and-live-lactic-acid-bacteria-isolated-from-thai-pigs-against-a-pandemic-strain-of-porcine-epidemic-diarrhea-virus
#1
Wandee Sirichokchatchawan, Gun Temeeyasen, Dachrit Nilubol, Nuvee Prapasarakul
Porcine epidemic diarrhea virus (PEDV) is a coronavirus which causes severe diarrhea and fatal dehydration in piglets. In general, probiotic supplements could enhance recovery and protect piglets against enteric pathogens. Seven local lactic acid bacteria (LAB), (Ent. faecium 79N and 40N, Lact. plantarum 22F, 25F and 31F, Ped. acidilactici 72N and Ped. pentosaceus 77F) from pig feces were well-characterized as high potential probiotics. Cell-free supernatants (CFS) and live LAB were evaluated for antiviral activities by co-incubation on Vero cells and challenged with a pandemic strain of PEDV isolated from pigs in Thailand...
April 22, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28433989/oral-contraceptives-after-bariatric-surgery
#2
Joël Schlatter
OBJECTIVE: Bariatric surgery offers a highly effective mode of treatment for obese patients. Some procedures such as bypass cause an alteration in normal gastrointestinal tract with possible consequences for the uptake of orally administered drugs. METHODS: We assessed the literature to ascertain whether the use of oral drugs and especially oral contraceptives is effective and adequate after bariatric surgery. RESULTS: The bioavailability of drugs could be affected by the solubility and pH of the modified medium after bariatric surgery and by the loss of gastrointestinal transporters...
April 22, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28433942/synthesis-and-characterization-of-poly-propylene-imine-dendrimer-grafted-gold-nanoparticles-as-nanocarriers-of-doxorubicin
#3
Marzieh Golshan, Mehdi Salami-Kalajahi, Mina Mirshekarpour, Hossein Roghani-Mamaqani, Maryam Mohammadi
The aim of current work is synthesis 4th-generation-poly(propylene imine) (PPI)-dendrimer modified gold nanoparticles (Au-G4A) as nanocarriers for doxorubicin (DOX) and studying in vitro drug release kinetics from nanocarriers into different media. Accordingly, AuNPs were synthesized by reduction of chloroauric acid (HAuCl4) aqueous solution with trisodium citrate and modified with cysteamine to obtain amine-functionalized (Au-NH2) nanoparticles. Au-NH2 nanoparticles were used as multifunctional cores and participated in Michael addition of acrylonitrile and reduction process by lithium aluminum hydride (LAH) to synthesize Au-G4A nanoparticles...
April 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28433941/self-assembled-dual-responsive-micelles-stabilized-with-protein-for-co-delivery-of-drug-and-sirna-in-cancer-therapy
#4
M R Aji Alex, Chetan Nehate, Srivani Veeranarayanan, D Sakthi Kumar, Ritu Kulshreshtha, Veena Koul
Design of safe and efficient vehicles for the combinatorial delivery of drugs and genetic agents is an emerging requisite for achieving enhanced therapeutic effect in cancer. Even though several nanoplatforms have been explored for the co-delivery of drugs and genetic materials the translation of these systems to clinical phase is still a challenge, mainly due to tedious synthesis procedures, lack of serum stability, inefficient scalability etc. Here in, we report development of reduction and pH sensitive polymeric graft of low molecular weight poly (styrene -alt -maleic anhydride) and evaluation of its efficacy in co-delivering drug and siRNA...
April 17, 2017: Biomaterials
https://www.readbyqxmd.com/read/28433917/hydrothermal-carbonisation-of-poultry-litter-effects-of-initial-ph-on-yields-and-chemical-properties-of-hydrochars
#5
Bashir M Ghanim, Witold Kwapinski, James J Leahy
In this study, hydrothermal carbonisation (HTC) of poultry litter (PL) was carried out to evaluate the impact of initial pH using acetic acid (CH3COOH) or sulfuric acid (H2SO4) on the yields and properties of hydrochar (HC). The PL samples were treated by HTC at various initial pH and at 250°C for 2h. The HCs produced were characterized by ultimate, proximate and fibre analyses as well as heating value and surface area measurements. The results indicated that undertaking HTC in the presence of acids (CH3COOH, H2SO4) significantly affects the yields and properties of HC...
April 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28433907/rapid-generation-of-volatile-fatty-acids-vfa-through-anaerobic-acidification-of-livestock-organic-waste-at-low-hydraulic-residence-time-hrt
#6
Kranti Kuruti, Shalini Nakkasunchi, Sameena Begum, Sudharshan Juntupally, Vijayalakshmi Arelli, Gangagni Rao Anupoju
The purpose of this study was to investigate the effect of pre-treatment and F/M (Food to Microorganism) ratios for the rapid generation of volatile fatty acids (VFA) from livestock organic wastes (cattle manure (CM) and poultry litter (PL)) through an anaerobic acidification process at a pH range of 4.5-5.5. Experiments were organized using CM and PL in batch reactors (1L and 25L) with and with no pre-treatment of substrate at F/M ratios (0.4, 0.6, 0.8 and 1). Among various existing pre-treatments methods, thermal-acidic (120°C; 1% H2SO4) pre-treatment was found effective...
April 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28433886/controlled-release-of-metformin-from-chitosan-based-nanocomposite-films-containing-mesoporous-mcm-41-nanoparticles-as-novel-drug-delivery-systems
#7
Zahra Shariatinia, Zahra Zahraee
Biocompatible nanocomposite films based on blended chitosan and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (BP) polymers containing metformin (MET) drug and MCM-41 or MCM-41-APS (APS=aminopropylsilane) nanoparticles (NPs) were designed and fabricated in order to prepare novel drug delivery systems which are useful for controlled drug release purposes. The total pore volume and mesopore volume of MCM-41 were measured equal to 1.08 and 1.05 cm(3)/g but those of MCM-41-APS were 0...
April 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28433873/ph-dependent-synthesis-of-two-isomeric-dinuclear-cerium-ii-complexes-structures-dna-interactions-cytotoxic-activity-and-apoptotic-study
#8
En-Jun Gao, Jun-Qi Su, Hai-Tao Jin, Si-Jia Liu, Fu-Chen Zhao, Yang Meng, Xiao-Yu Ma, Jing Ge, Ya-Guang Sun, Wanzhong Zhang, Ming-Chang Zhu
Two isomeric dinuclear Cerium(II) complexes 1 and 2, formulated as Ce2(phen)2(NO3)2(L)4 [L=phenylacetic acid, phen=1,10-phenanthroline] was synthesized under solvothermal conditions at different pH values. The two complexes were characterized by elemental analysis, IR and single crystal X-ray diffraction. Complexes 1 and 2 were studied the binding with DNA and against cytotoxic activity. Fluorescence analysis indicated that the two complexes can bind to DNA. The changes with different gradient concentration of DNA added into the complexes in absorption spectra show a strongπ-stacking interaction between the complexes and DNA base pairs...
April 11, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28433865/high-sensitivity-hplc-method-for-analysis-of-in-vivo-extracellular-gaba-using-optimized-fluorescence-parameters-for-o-phthalaldehyde-opa-sulfite-derivatives
#9
Shannon L Zandy, James M Doherty, Nathan D Wibisono, Rueben A Gonzales
Reversed-phase HPLC with derivatization using o-phthalaldehyde (OPA) and sulfite allows electrochemical detection of γ-aminobutyric acid (GABA) in microdialysis samples. However, OPA/sulfite derivatives have been reported to produce lower fluorescent yield than OPA derivatives using organic thiols as the nucleophile. To overcome this limitation we examined excitation and emission spectra, reaction time, pH, and concentration of reagents in the derivatization solution. Optimal detection parameters were determined as λex=220nm and λem=385nm for maximal fluorescence...
April 3, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28433787/facile-encapsulation-of-hydroxycamptothecin-nanocrystals-into-zein-based-nanocomplexes-for-active-targeting-drug-delivery-and-cell-imaging
#10
Hongdi Wang, Wei Zhu, Yunna Huang, Zhixian Li, Yanbin Jiang, Qiuling Xie
Nano-drug delivery systems that integrate inorganic and organic or even bioactive components into a single nanoscale platform are playing a greatly important role in cancer treatment. Here, the fabrication of a versatile nanocarrier based on self-assembled structures of gold nanoparticles (AuNPs)-zein is reported, which displays high drug-loading efficiency for needle-shaped hydroxycamptothecin (HCPT) nanocrystals. The surface modification with folate-conjugated polydopamine (PFA) renders them stable and also facilitates their selective cellular internalization and enhancement of endocytosis...
April 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28433765/geochemical-processes-controlling-the-distribution-and-concentration-of-metals-in-soils-from-a-patagonian-argentina-salt-marsh-affected-by-mining-residues
#11
Yanina L Idaszkin, María Del Pilar Alvarez, Eleonora Carol
Heavy metal pollution that affects salt marshes is a major environmental concern due to its toxic nature, persistence, and potential risk to organisms and to human health. Mining waste deposits originated four decades ago, by the metallurgical extraction of heavy metals, are found near to the San Antonio salt marsh in Patagonia. The aim of the work was to determine the geochemical processes that control the distribution and concentration of Cu, Fe, Pb and Zn in the soils of this Patagonian salt marsh. A survey of the mining waste deposits was carried out where three dumps were identified...
April 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28433695/disinfection-of-water-inoculated-with-enterococcus-faecalis-using-solar-fe-iii-edds-h2o2-or-s2o8-2-process
#12
A Bianco, M I Polo López, P Fernández Ibáñez, M Brigante, G Mailhot
In this study, the activation of H2O2 and persulfate ions induced by solar photolysis of Fe(III)EDDS complex were investigated in water disinfection, applying solar AOPs processes. The use of Fe(III)EDDS complex maintains iron in soluble form until slightly basic pH and so the photolysis is efficient in a large range of pH compatible with natural waters. Moreover, for the first time, the impact of photogenerated hydroxyl and sulfate radicals on the inactivation of Enterococcus faecalis in water was studied...
April 18, 2017: Water Research
https://www.readbyqxmd.com/read/28433657/mir-938-promotes-colorectal-cancer-cell-proliferation-via-targeting-tumor-suppressor-phlpp2
#13
Chang-Feng Li, Yong-Chao Li, Jing-Peng Jin, Zhen-Kun Yan, Dan-Dan Li
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Although the development of therapy approaches, the outcome of CRC patients still is poor, understanding the biological mechanism of CRC progression is critical to improve the treatment strategies. miRNAs regulate CRC progression, we found miR-938 was upregulated in CRC tissues and cells, MTT assay, colony formation assay and soft agar growth assay suggested miR-938 overexpression promoted CRC cell proliferation, miR-938 knockdown inhibited CRC cell proliferation...
April 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28433571/antitumor-and-chemosensitizing-action-of-3-bromopyruvate-implication-of-deregulated-metabolism
#14
Saveg Yadav, Shrish Kumar Pandey, Ajay Kumar, Praveen Kumar Kujur, Rana Pratap Singh, Sukh Mahendra Singh
3-Bromopyruvate (3-BP), brominated derivative of pyruvate, possesses strong antitumor potential, owing to its ability to inhibit multiple target molecules crucial for survival of neoplastic cells. Although, 3-BP displays cytotoxicity against a wide variety of tumors, there is no report with respect to malignancies of thymic origin. Therefore, we investigated its antineoplastic action in vitro against tumor cells of a murine transplantable lymphoma of thymoma origin, designated as Dalton's lymphoma (DL). 3-BP treatment of tumor cells inhibited metabolism and survival with augmented induction of apoptosis and necrosis...
April 19, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28433433/design-selection-and-development-of-cyclic-peptide-ligands-for-human-erythropoietin
#15
William S Kish, Hiroyuki Sachi, Amith D Naik, Matthew K Roach, Benjamin G Bobay, Robert K Blackburn, Stefano Menegatti, Ruben G Carbonell
This work presents the selection and characterization of erythropoietin (EPO)-binding cyclic peptide ligands. The sequences were selected by screening a focused library of cyclic depsipeptides cyclo[(Nα-Ac)Dap(A)-X1-X6-AE], whose structure and amino acid compositions were tailored to mimic the EPO receptor. The sequences identified through library screening were synthesized on chromatographic resin and characterized via binding-and-elution studies against EPO to select a pool of candidate ligands. Sequences with higher hydrophobicity consistently showed stronger binding to EPO, with the exception of FSLLSH, which was noted for its lower hydrophobicity and high EPO binding...
April 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28433193/regulation-of-the-catalytic-behavior-of-pullulanases-chelated-onto-nickel-ii-modified-magnetic-nanoparticles
#16
Jianfeng Wang, Zhongmei Liu, Zhemin Zhou
Chelating of pullulanases onto nickel (II)-modified magnetic nanoparticles results in one-step purification and immobilization of pullulanase, and facilitates the commercial application of pullulanase in industrial scale. To improve the catalytic behavior, especially the operational stability, of the nanocatalyst in consecutive batch reactions, we prepared various iminodiacetic acid-modified magnetic nanoparticles differed in surface polarity and spacer length, on which the His6-tagged pullulanases were chelated via nickel ions, and then studied the correlation between the MNPs surface property and the corresponding catalyst behavior...
June 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28433169/effectiveness-of-n-o-carboxymethyl-chitosan-on-destabilization-of-marine-diesel-diesel-and-marine-2t-oil-for-oil-spill-treatment
#17
Bhairavi Doshi, Eveliina Repo, Juha P Heiskanen, Juho Antti Sirviö, Mika Sillanpää
Oil spills are the significant sources of hydrocarbons entering in the receiving aquatic environment. An efficient method to remove hydrocarbons from water resources is adsorption. In this study, water soluble N,O-carboxymethyl chitosan (NO-CS) was synthesized by carboxymethylation of chitosan in a hydro-alcoholic medium at 50°C by chloroacetic acid. The polymer was characterized through degree of deacetylation, degree of substitution, FTIR and (1)H NMR. Effectiveness of NO-CS as an adsorbent was studied as a function of dosage, salinity and pH to destabilize the Marine diesel (Oil-1), Diesel (Oil-2) and Marine-2T oil (Oil-3) into small oil droplets of less than 100μm...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433166/chitosan-graphene-oxide-films-and-co2-dried-porous-aerogel-microspheres-interfacial-interplay-and-stability
#18
Sana Frindy, Ana Primo, Hamid Ennajih, Abou El Kacem Qaiss, Rachid Bouhfid, Mohamed Lahcini, El Mokhtar Essassi, Hermenegildo Garcia, Abdelkrim El Kadib
The intimate interplay of chitosan (CS) and graphene oxide (GO) in aqueous acidic solution has been explored to design upon casting, nanostructured "brick-and-mortar" films (CS-GO-f) and by acidic-to-basic pH inversion, porous CO2-dried aerogel microspheres (CS-GO-m). Owing to the presence of oxygenated functional groups in GO, good-quality crack-free hybrid films were obtained. Mechanical properties were improved independently of the GO content and it was found that a 20wt% loading affords hybrid film characterized with a Young modulus three times superior to that reached with the same loading of layered clay...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433165/efficiency-of-xylanases-from-families-10-and-11-in-production-of-xylo-oligosaccharides-from-wheat-arabinoxylans
#19
Natalie K Morgan, Andrew Wallace, Michael R Bedford, Mingan Choct
This study investigated the effect of xylanases from families 10 and 11 on the production of small chain arabinoxylo-oligosaccharides (AXOS) (X2-X4) from wheat arabinoxylans, and identified the impact that pH, temperature and time exposed to xylanase have on this process. Xylanase from family 10 had greater hydrolytic efficiency and resulted in heightened AXOS production compared with xylanase from family 11 or family 10 and 11 combined. The pH of the environment had a significant effect on AXOS production (P<0...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433154/non-immunogenic-porous-and-antibacterial-chitosan-and-antheraea-mylitta-silk-sericin-hydrogels-as-potential-dermal-substitute
#20
Sunaina Sapru, Ananta K Ghosh, Subhas C Kundu
Limitation of existing grafts including restricted donor site, risks of immune reactions, infectious diseases and high cost alarms the growing need of natural, cost effective and functional graft as the dermal substitute. We fabricate stable (>6 weeks) and porous (57.23-75.22μm) yet flexible (in variable pH) matrices using Antheraea mylitta sericin crosslinked with well known biocompatible polysaccharide chitosan by natural crosslinker (genipin) without using any harsh chemical. The fabricated matrices are characterized in terms of chemical modifications (Fourier transform infrared spectroscopy), crystallinity (X-ray diffraction), swelling, degradability and thermal stability...
July 1, 2017: Carbohydrate Polymers
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