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https://www.readbyqxmd.com/read/29036351/mirandola-2017-a-curated-knowledge-base-of-non-invasive-biomarkers
#1
Francesco Russo, Sebastiano Di Bella, Federica Vannini, Gabriele Berti, Flavia Scoyni, Helen V Cook, Alberto Santos, Giovanni Nigita, Vincenzo Bonnici, Alessandro Laganà, Filippo Geraci, Alfredo Pulvirenti, Rosalba Giugno, Federico De Masi, Kirstine Belling, Lars J Jensen, S Ren Brunak, Marco Pellegrini, Alfredo Ferro
miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29032399/evidence-of-extracellular-vesicles-biogenesis-and-release-in-mouse-embryonic-stem-cells
#2
Lilian Cruz, Jenny Andrea Arevalo Romero, Mariana Brandão Prado, Tiago G Santos, Marilene Hohmuth Lopes
Extracellular vesicles (EVs) released by mouse embryonic stem cells (mESCs) are considered a source of bioactive molecules that modulate their microenvironment by acting on intercellular communication. Either intracellular endosomal machinery or their derived EVs have been considered a relevant system of signal circuits processing. Herein, we show that these features are found in mESCs. Ultrastructural analysis revealed structures and organelles of the endosomal system such as coated pits and endocytosis-related vesicles, prominent rough endoplasmic reticulum and Golgi apparatus, and multivesicular bodies (MVBs) containing either few or many intraluminal vesicles (ILVs) that could be released as exosomes to extracellular milieu...
October 14, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29030596/mesenchymal-stem-cells-from-tumor-microenvironment-favour-breast-cancer-stem-cell-proliferation-cancerogenic-and-metastatic-potential-via-ionotropic-purinergic-signalling
#3
A Maffey, C Storini, C Diceglie, C Martelli, L Sironi, C Calzarossa, N Tonna, R Lovchik, E Delamarche, L Ottobrini, F Bianco
Interaction between tumor cells and the microenvironment is key in initiation, progression, and invasiveness of cancer. In particular, mesenchymal stem cells (MSCs) are recruited to the sites of developing tumors, thus promoting metastasis formation. Although it is well known that MSCs migrate and integrate in the tumor microenvironment (TME), their fate and function inside the tumor is still not clear. In this study, we analyzed the role played by MSCs in breast cancer oncogenesis. Data indicate that interaction of breast cancer cells with MSCs results in an increased proliferation and metabolic activity of breast cancer cells, partially due to MSC-derived microvesicles that are shed in the TME...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024380/cell-to-cell-communication-micrornas-as-hormones
#4
REVIEW
Recep Bayraktar, Katrien Van Roosbroeck, George A Calin
Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell-to-cell communication within the tumor microenvironment. EVs' components, such as proteins, non-coding RNAs [microRNAs (miRNAs) and long non-coding RNAs (lncRNAs)], messenger RNAs (mRNAs), DNA, and lipids, can mediate paracrine signaling in the tumor microenvironment. Recently, miRNAs encapsulated in secreted EVs have been identified in the extracellular space...
October 11, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29022142/microvesicle-mediated-delivery-of-mir-1343-impact-on-markers-of-fibrosis
#5
Lindsay R Stolzenburg, Ann Harris
Tissue fibrosis, the development of fibrous connective tissue as a result of injury or damage, is associated with many common diseases and cannot be treated effectively. The complex biological processes accompanying fibrosis often involve aberrant signaling through the transforming growth factor beta (TGF-β) pathway. In the search for mechanisms to repress this signaling, microRNAs have emerged as a novel class of molecules capable of targeting single members of the TGF-β pathway, or the pathway as a whole...
October 11, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28993771/tumor-derived-microvesicles-modulate-antigen-cross-processing-via-reactive-oxygen-species-mediated-alkalinization-of-phagosomal-compartment-in-dendritic-cells
#6
Federico Battisti, Chiara Napoletano, Hassan Rahimi Koshkaki, Francesca Belleudi, Ilaria Grazia Zizzari, Ilary Ruscito, Sara Palchetti, Filippo Bellati, Pierluigi Benedetti Panici, Maria Rosaria Torrisi, Giulio Caracciolo, Fabio Altieri, Marianna Nuti, Aurelia Rughetti
Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8(+) T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo mechanisms underlying efficient antigen cross-processing and presentation are not fully understood. Several pieces of evidence indicate that antigen transfer to DCs mediated by microvesicles (MVs) enhances antigen immunogenicity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28982475/secretome-derived-from-different-cell-lines-in-bovine-embryo-production-in-vitro
#7
C Perrini, P Esposti, F Cremonesi, A Lange Consiglio
The present study investigated the effects of conditioned medium (CM), composed of microvesicles (MVs) and soluble factors present in the supernatant (SN), of bovine endometrial and amniotic cells on embryo quality and rate of blastocyst production. Presumptive zygotes were randomly assigned on Days 1, 3 and 5 after fertilisation to synthetic oviducal fluid with amino acids (SOFaa; control) or to SOFaa supplemented with either 20% endometrial or amniotic CM, 20% SN or 100×106MVsmL-1. Embryos were evaluated on Day 7...
October 6, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28979244/lactobacillus-casei-bl23-produces-microvesicles-carrying-proteins-that-have-been-associated-with-its-probiotic-effect
#8
A Paula Domínguez Rubio, Jimena H Martínez, Diana C Martínez Casillas, Federico Coluccio Leskow, Mariana Piuri, Oscar E Pérez
Archaea, bacteria, and eukarya secrete membrane microvesicles (MVs) as a mechanism for intercellular communication. We report the isolation and characterization of MVs from the probiotic strain Lactobacillus casei BL23. MVs were characterized using analytical high performance techniques, DLS, AFM and TEM. Similar to what has been described for other Gram-positive bacteria, MVs were on the nanometric size range (30-50 nm). MVs carried cytoplasmic components such as DNA, RNA and proteins. Using a proteomic approach (LC-MS), we identified a total of 103 proteins; 13 exclusively present in the MVs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28978702/coxsackievirus-b-escapes-the-infected-cell-in-ejected-mitophagosomes
#9
Jon Sin, Laura McIntyre, Aleksandr Stotland, Ralph Feuer, Roberta A Gottlieb
Coxsackievirus B (CVB) is a common enterovirus that can cause various systemic inflammatory diseases. Because CVB lacks an envelope, it has been thought to be inherently cytolytic, wherein CVB can only escape from the infected host cell by causing it to rupture. In recent years, however, we and others have observed that various naked viruses such as CVB can trigger the release of infectious extracellular microvesicles (EMVs) that contain viral material. This mode of cellular escape has been suggested to allow the virus to be masked from the adaptive immune system...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28975970/facilitation-of-ultrasonic-microvesicles-on-homing-and-molecular-mechanism-of-bone-marrow-mesenchymal-stem-cells-in-cerebral-infarction-patients
#10
F Chang, W Xiong, D Wang, X-Z Liu, W Zhang, M Zhang, P Jing
OBJECTIVE: Cerebral infarction, or ischemia brain stroke, is a common cerebrovascular disease. Bone marrow mesenchymal stem cells (BMSCs) are widely used to treating ischemia disease such as cardiac infarction. Ultrasonic microvesicles may help the targeting of exogenous factors via localized energy blast. Therefore, this study aims to investigate the effect of ultrasonic microvesicles on the homing of BMSCs on artery thrombosis and the associated molecular mechanisms. MATERIALS AND METHODS: Rat BMSCs were isolated and cultured...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28972069/evolution-of-cancer-stem-like-cells-in-endocrine-resistant-metastatic-breast-cancers-is-mediated-by-stromal-microvesicles
#11
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28969681/mesenchymal-stem-cells-microvesicles-stabilize-endothelial-barrier-function-partly-mediated-by-hepatocyte-growth-factor-hgf
#12
Hualing Wang, Ruiqiang Zheng, Qihong Chen, Jun Shao, Jiangquan Yu, Shuling Hu
BACKGROUND: Mesenchymal stem cells microvesicles (MSC-MVs) stabilize endothelial barrier function in acute lung injury (ALI); however, the detailed mechanism remains to be further defined. Hepatocyte growth factor (HGF), which is derived from MSC-MVs, might have a key role in the restoration of endothelial barrier function by MSC-MVs. METHODS: MSCs with lentiviral vector-mediated HGF gene knockdown (siHGF-MSC) were generated. A co-culture model of pulmonary microvascular endothelial cells and MSC-MVs collected from MSCs or siHGF-MSCs after 24 h of hypoxic culture was utilized...
September 29, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28968422/autographa-californica-multiple-nucleopolyhedrovirus-ac75-is-required-for-egress-of-nucleocapsids-from-the-nucleus-and-formation-of-de-novo-intranuclear-membrane-microvesicles
#13
Ya-Jun Guo, Shi-Hui Fu, Lu-Lin Li
In this study, Autographa californica multiple nucleopolyhedrovirus ac75 was functionally characterized. Ac75 has homologs in all sequenced genomes of alphabaculoviruses, betabaculoviruses, and gammabaculoviruses. It was determined to encode a protein that is associated with the nucleocapsid of budded virus and with both envelope and nucleocapsids of occlusion-derived virus. Sf9 cells transfected by an ac75-knockout bacmid resulted in the infection being restricted to single cells. No budded virus were detected although viral DNA replication and late gene expression were unaffected...
2017: PloS One
https://www.readbyqxmd.com/read/28965750/emerging-role-of-extracellular-vesicles-in-musculoskeletal-diseases
#14
REVIEW
Cameron Murphy, Joseph Withrow, Monte Hunter, Yutao Liu, Yao Liang Tang, Sadanand Fulzele, Mark W Hamrick
Research into the biology of extracellular vesicles (EVs), including exosomes and microvesicles, has expanded significantly with advances in EV isolation techniques, a better understanding of the surface markers that characterize exosomes and microvesicles, and greater information derived from -omics approaches on the proteins, lipids, mRNAs, and microRNAs (miRNAs) transported by EVs. We have recently discovered a role for exosome-derived miRNAs in age-related bone loss and osteoarthritis, two conditions that impose a significant public health burden on the aging global population...
October 10, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28963073/bm-mscs-derived-microvesicles-promote-allogeneic-kidney-graft-survival-through-enhancing-micro-146a-expression-of-dendritic-cells
#15
Xiao-Qiang Wu, Tian-Zhong Yan, Zhi-Wei Wang, Xuan Wu, Guang-Hui Cao, Chan Zhang
OBJECTIVE: Microvesicles (MVs) are plasmalemmal vesicles that are released from various cells and regarded as a mediator of intermolecular communication. In present study, we aimed to evaluate the therapeutic efficacy of the bone marrow mesenchymal stem cells (BM-MSCs)-derived MVs in the mice kidney transplant model and explored the underlying mechanism. METHODS: BM-MSCs were isolated from C57BL/6 mice and identified using flow cytometry. In vivo allogenic kidney transplantation model of mice was performed between C57BL/6 mice (recipient) and BALB/c mice (donor)...
September 28, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28962834/peptidyl-prolyl-isomerase-1-pin1-preserves-the-phosphorylation-state-of-tissue-factor-and-prolongs-its-release-within-microvesicles
#16
Camille Ettelaie, Mary E W Collier, Sophie Featherby, John Greenman, Anthony Maraveyas
The exposure and release of TF is regulated by post-translational modifications of its cytoplasmic domain. Here, the potential of Pin1 to interact with the cytoplasmic domain of TF, and the outcome on TF function was examined. MDA-MB-231 and transfected-primary endothelial cells were incubated with either Pin1 deactivator Juglone, or its control Plumbagin, as well as transfected with Pin1-specific or control siRNA. TF release into microvesicles following activation, and also phosphorylation and ubiquitination states of cellular-TF were then assessed...
September 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28955186/extracellular-vesicles-evolutionarily-conserved-mediators-of-intercellular-communication
#17
REVIEW
Charlotte Lawson, Dory Kovacs, Elizabeth Finding, Emily Ulfelder, Virginia Luis-Fuentes
Extracellular vesicles (EV) are sub-micron circulating vesicles found in all bodily fluids and in all species so far tested. They have also recently been identified in seawater and it has further been shown that they are released from microorganisms and may participate in interspecies communication in the gut. EV are typically composed of a lipid bilayer formed from the plasma membrane and which encases a cargo that can include genetic material, proteins, and lipids. At least two different processes of formation and release have been described in mammalian cells...
September 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28955033/plasma-membrane-derived-extracellular-microvesicles-mediate-non-canonical-intercellular-notch-signaling
#18
Qiyu Wang, Quan Lu
ARMMs (arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles) are extracellular vesicles that bud directly at the plasma membrane; however, little is known about the molecular composition and physiological function of these vesicles. Here we report that ARMMs contain active NOTCH receptors and mediate a non-canonical intercellular NOTCH signaling. We identify over 100 proteins that are significantly enriched in ARMMs, including ARRDC1, TSG101 and multiple ESCRT complex proteins. About a third of ARMMs-enriched proteins are plasma membrane proteins, including the NOTCH2 receptor...
September 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28951723/microvesicles-derived-from-indoxyl-sulfate-treated-endothelial-cells-induce-endothelial-progenitor-cells-dysfunction
#19
Andres Carmona, Fatima Guerrero, Paula Buendia, Teresa Obrero, Pedro Aljama, Julia Carracedo
Cardiovascular disease is a major cause of mortality in chronic kidney disease patients. Indoxyl sulfate (IS) is a typical protein-bound uremic toxin that cannot be effectively cleared by conventional dialysis. Increased IS is associated with the progression of chronic kidney disease and development of cardiovascular disease. After endothelial activation by IS, cells release endothelial microvesicles (EMV) that can induce endothelial dysfunction. We developed an in vitro model of endothelial damage mediated by IS to evaluate the functional effect of EMV on the endothelial repair process developed by endothelial progenitor cells (EPCs)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28950217/breast-cancer-extracellular-vesicles-induce-platelet-activation-and-aggregation-by-tissue-factor-independent-and-dependent-mechanisms
#20
Fausto G Gomes, Vanessa Sandim, Vitor H Almeida, Araci M R Rondon, Barbara B Succar, Eugenio D Hottz, Ana Carolina Leal, Brunno Renato F Verçoza, Juliany Cola F Rodrigues, Patrícia T Bozza, Russolina B Zingali, Robson Q Monteiro
INTRODUCTION: Cancer-associated thrombosis is one of the major causes of worse prognosis among tumor-bearing patients. Extracellular vesicles derived from cancer cells, which can be divided mainly into microvesicles and exosomes, can participate in several tumor progression phenomena. Tumor-derived microvesicles positive for tissue factor (TF) have been associated with thrombotic risk in certain cancer types. Cancer cell-derived exosomes, however, have not. In this study we evaluated the capacity of extracellular vesicles (EVs, containing both microvesicles and exosomes) derived from breast-cancer cell lines in promoting platelet activation, aggregation and plasma coagulation, in experiments that access both TF-dependent and -independent activities...
September 21, 2017: Thrombosis Research
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