keyword
https://read.qxmd.com/read/38546065/prevalence-of-bk-and-jc-polyomaviruses-among-patients-with-breast-cancer
#1
JOURNAL ARTICLE
Zohreh Alipour, Gholam Abbas Kaydani, Manoochehr Makvandi, Mahsa Javadi, Abdolhosein Talaeizadeh
INTRODUCTION: Breast cancer, a pervasive invasive carcinoma among women globally, afflicts approximately 12% of women worldwide. Previous studies have indicated that certain viruses, including oncogenic viruses such as polyomaviruses BK and JC, may play a role in the development of breast cancer. In light of this, the present study endeavors to assess the incidence of BKV and JCV virus in breast cancer patients. MATERIALS AND METHODS: One hundred formalin-fixed paraffin-embedded tissue samples were procured and subjected to deparaffinize by xylene, followed by DNA extraction through the phenol-chloroform methodology...
March 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38545425/comparison-of-long-term-outcome-between-clinically-high-risk-lobular-versus-ductal-breast-cancer-a-propensity-score-matched-study
#2
JOURNAL ARTICLE
Francesca Magnoni, Giovanni Corso, Patrick Maisonneuve, Beatrice Bianchi, Giuseppe Accardo, Claudia Sangalli, Giulia Massari, Anna Rotili, Luca Nicosia, Filippo Pesapane, Emilia Montagna, Giovanni Mazzarol, Viviana Galimberti, Paolo Veronesi, Giuseppe Curigliano
BACKGROUND: Abemaciclib is currently approved for the adjuvant treatment of high-risk, lymph node (LN)-positive, hormone receptor (HR)-positive breast cancer (BC). In a real-world setting the clinicopathologic features of patients potentially eligible for adjuvant abemaciclib remain to be defined. There are conflicting data regarding the biological behavior and long-term outcomes across invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC). In our study we retrospectively assessed the real-world data and long-term outcome of selected high-risk features ILC compared to IDC, according to the MonarchE trial inclusion criteria...
May 2024: EClinicalMedicine
https://read.qxmd.com/read/38539179/association-of-hormone-receptors-and-human-epidermal-growth-factor-receptor-2-neu-expressions-with-clinicopathologic-factors-of-breast-carcinoma-a-cross-sectional-study-in-a-tertiary-care-hospital-kabul-afghanistan
#3
JOURNAL ARTICLE
Esmatullah Esmat, Ahmed Maseh Haidary, Ramin Saadaat, Syeda Naghma Rizvi, Syeda Aleena, Mujtaba Haidari, Sayed Murtaza Sadat Hofiani, Nasrin Hussaini, Ahmadullah Hakimi, Abdullatif Khairy, Jamshid Abdul-Ghafar
BACKGROUND: Breast cancer (BC) is one of the major causes of death worldwide. It is the most common cause of death before the age of 70 years. The incidence and mortality of BC are rapidly increasing, posing great challenges to the health system and economy of every nation. METHODOLOGY: A cross-sectional analytical study was conducted at the Department of Pathology and Clinical Laboratory of the French Medical Institute for Mothers and Children (FMIC) to demonstrate the association of human epidermal growth factor receptor 2 (Her2/Neu) and estrogen receptor (ER)/ progesterone receptor (PR) with clinical as well as pathological parameters among women with BC...
March 27, 2024: BMC Cancer
https://read.qxmd.com/read/38527731/intra-and-peritumoral-pet-radiomics-analysis-to-predict-the-pathological-response-in-breast-cancer-patients-receiving-neoadjuvant-chemotherapy
#4
JOURNAL ARTICLE
Ayşegül Aksu, Güç Zeynep Gülsüm, Kadir Alper Küçüker, Ahmet Alacacıoğlu, Bülent Turgut
OBJECTIVE: The aim of our study was to evaluate the contribution of 18Fluorine-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) radiomic data obtained from both the tumoral and peritumoral area in predicting pathological complete response (pCR) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy (NAC). METHODS: Female patients with a diagnosis of invasive ductal carcinoma who received NAC were evaluated retrospectively...
March 23, 2024: Revista española de medicina nuclear e imagen molecular
https://read.qxmd.com/read/38525417/case-report-fibroadenomas-associated-with-atypical-ductal-hyperplasia-and-infiltrating-epitheliosis-mimicking-invasive-carcinoma
#5
Li Wang, Wei Zhao, Jue Zhou, Rong Ge
Infiltrating epitheliosis (IE) is an uncommon type of complex sclerosing lesion in the breast. This condition is characterized by the infiltration of ducts into a scleroelastotic stroma, along with the presence of cells that display architectural and cytological patterns similar to those observed in usual ductal hyperplasia. We herein report a case of a 24-year-old woman who presented with bilateral breast nodules, which were initially identified as multiple fibroadenomas based on ultrasound findings. The patient underwent Mammotome system and regional mastectomy procedures, and subsequent pathological analysis confirmed the presence of multiple fibroadenomas with atypical ductal hyperplasia and infiltrating epitheliosis...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38523415/delayed-diagnosis-of-inflammatory-breast-cancer-presenting-as-acute-mastitis-in-a-patient-one-month-postpartum
#6
JOURNAL ARTICLE
Ananya Seth, Eliza M Slama
Inflammatory breast cancer (IBC) is a rare yet aggressive form of invasive ductal carcinoma, with a poor prognosis and decreased 5-year survival rates. Characteristic findings for IBC include rapid onset of breast edema, peau d'orange appearance, and involvement of the breast skin. Additionally, diagnosis is confirmed with a skin punch biopsy. With such nonspecific features, IBC can be mistaken for benign etiologies, causing delays in diagnosis and treatment. This patient is a 44-year-old woman presenting with left breast swelling while concurrently breastfeeding...
March 24, 2024: American Surgeon
https://read.qxmd.com/read/38523303/recurrent-severe-hypocalcemia-following-chemotherapy-regimen-changes-in-advanced-breast-cancer-two-case-reports
#7
JOURNAL ARTICLE
Yurina Yanase, Hiroko Bando, Riko Sato, Tomohei Matsuo, Aya Ueda, Mai Okazaki, Sachie Hashimoto, Akiko Iguchi-Manaka, Hisato Hara
BACKGROUND: As an oncologic emergency related to abnormalities in calcium metabolism, hypercalcemia associated with paraneoplastic syndrome and bone metastases is well known. Meanwhile, the incidence of hypocalcemia is low, except in cases associated with bone-modifying agents used for bone metastases. Hypocalcemia induced by bone-modifying agents typically occurs early after the initial administration, and its incidence can be significantly reduced by preventive administration of calcium and vitamin D3 supplements...
March 25, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38523186/multi-omic-profiling-of-simultaneous-ductal-carcinoma-in-situ-and-invasive-breast-cancer
#8
JOURNAL ARTICLE
Henry G Kaplan, Alexa K Dowdell, Anna B Berry, Racheli Ben Shimol, Fred L Robinson, Christopher A Carney, Brian D Piening
PURPOSE: The progression of ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) in humans is highly variable. To better understand the relationship between them, we performed a multi-omic characterization of co-occurring DCIS and IBC lesions in a cohort of individuals. METHODS: Formalin-fixed paraffin-embedded tissue samples from 50 patients with co-occurring DCIS and IBC lesions were subjected to DNA-seq and whole transcriptome RNA-seq. Paired DCIS and IBC multi-omics profiles were then interrogated for DNA mutations, gene expression profiles and pathway analysis...
March 24, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38520579/clinicopathological-predictors-of-positive-resection-margins-in-breast-conserving-surgery
#9
JOURNAL ARTICLE
Hemali Chauhan, Natasha Jiwa, Vikneswaran Raj Nagarajan, Paul Thiruchelvam, Katy Hogben, Ragheed Al-Mufti, Dimitri Hadjiminas, Sami Shousha, Ramsey Cutress, Hutan Ashrafian, Zoltan Takats, Daniel Richard Leff
BACKGROUND: Ductal carcinoma in situ (DCIS) is associated with risk of positive resection margins following breast-conserving surgery (BCS) and subsequent reoperation. Prior reports grossly underestimate the risk of margin positivity with IBC containing a DCIS component (IBC + DCIS) due to patient-level rather than margin-level analysis. OBJECTIVE: The aim of this study was to delineate the relative risk of IBC + DCIS compared with pure IBC (without a DCIS component) on margin positivity through detailed margin-level interrogation...
March 23, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38518978/assessing-endoscopic-ultrasound-guided-radiofrequency-ablation-in-unresectable-pancreatic-ductal-adenocarcinoma-a-single-center-historic-cohort-study
#10
JOURNAL ARTICLE
Carlos Robles-Medranda, Raquel Del Valle, Miguel Puga-Tejada, Martha Arevalo-Mora, Domenica Cunto, Maria Egas-Izquierdo, Lorena Estrada-Guevara, Orlando Bunces-Orellana, Daniel Moreno-Zambrano, Juan Alcivar-Vasquez, Haydee Alvarado-Escobar, Ruxandra C Merfea, Jonathan Barreto-Perez, Jorge Rodriguez, Daniel Calle-Loffredo, Hannah Pitanga-Lukashok, Jorge Baquerizo-Burgos, Daniela Tabacelia
BACKGROUND: /aims: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) has emerged as an alternative for the local treatment of unresectable pancreatic ductal adenocarcinoma (PDAC). We aim to assess the feasibility and safety of EUS-RFA in patients with unresectable PDAC. METHODS: The following was a historic cohort compounded by locally advanced (LA) and metastatic (m) PDAC naïve patients, who underwent EUS-RFA between October 2019 to March 2022...
March 20, 2024: Gastrointestinal Endoscopy
https://read.qxmd.com/read/38518165/re-evaluation-of-ipsilateral-multiple-focal-breast-cancer-case-report-and-literature-review
#11
JOURNAL ARTICLE
Lei Hou, Ziyi Fan, Luming Zheng
OBJECTIVE: Ipsilateral multiple breast cancer is a unique situation in which multiple breast cancer lesions are present in the same or different quadrant of the breast. While current research on ipsilateral multiple breast cancer primarily focuses on its existence or heterogeneity, it is important to evaluatethe risk level stratification of heterogenous lesion and determine the intensity of anti-tumor treatments for every lesion, achieving a rational and personalized anti-cancer strategy...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38517441/intraoperative-evaluation-of-breast-tissues-during-breast-cancer-operations-using-the-masspec-pen
#12
JOURNAL ARTICLE
Kyana Y Garza, Mary E King, Chandandeep Nagi, Rachel J DeHoog, Jialing Zhang, Marta Sans, Anna Krieger, Clara L Feider, Alena V Bensussan, Michael F Keating, John Q Lin, Min Woo Sun, Robert Tibshirani, Christopher Pirko, Kirtan A Brahmbhatt, Ahmed R Al-Fartosi, Alastair M Thompson, Elizabeth Bonefas, James Suliburk, Stacey A Carter, Livia S Eberlin
IMPORTANCE: Surgery with complete tumor resection remains the main treatment option for patients with breast cancer. Yet, current technologies are limited in providing accurate assessment of breast tissue in vivo, warranting development of new technologies for surgical guidance. OBJECTIVE: To evaluate the performance of the MasSpec Pen for accurate intraoperative assessment of breast tissues and surgical margins based on metabolic and lipid information. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study conducted between February 23, 2017, and August 19, 2021, the mass spectrometry-based device was used to analyze healthy breast and invasive ductal carcinoma (IDC) banked tissue samples from adult patients undergoing breast surgery for ductal carcinomas or nonmalignant conditions...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38512628/long-term-outcome-of-9g-mri-guided-vacuum-assisted-breast-biopsy-results-of-293-single-center-procedures-and-underestimation-rate-of-high-risk-lesions-over-12%C3%A2-years
#13
JOURNAL ARTICLE
Giuseppe Rescinito, Nicole Brunetti, Alessandro Garlaschi, Simona Tosto, Licia Gristina, Benedetta Conti, Diletta Pieroni, Massimo Calabrese, Alberto Stefano Tagliafico
PURPOSE: Breast magnetic resonance imaging (MRI) can detect some malignant lesions that are not visible on mammography (MX) or ultrasound (US). If a targeted, second-look fails, MRI-guided breast biopsy is the only available tool to obtain a tissue sample and pathological proof of these "MRI-only lesions". The aim of this study is to report the performance and underestimation rate of 9G MRI-guided vacuum-assisted breast biopsy (VABB) over 12 years at a single center. MATERIAL AND METHODS: All 9G MRI-VABB procedures performed from January 2010 to December 2021 were retrospectively reviewed...
March 21, 2024: La Radiologia Medica
https://read.qxmd.com/read/38507631/histopathological-feature-of-early-onset-breast-cancer-a-comparative-analysis
#14
JOURNAL ARTICLE
Iraj Feizi, Khatereh Isazadehfar, Farshid Sadegzadeh, Paniz Farshadi
BACKGROUND: Breast cancer is one of the most common malignancies among women. In some reports, it has been specified that the diagnosis of breast cancer at an earlier ages worsens the prognosis; this can be attributed to a combination of factors such as advanced stage of disease and late demonstration. Considering different results in last studies, this study's aim was investigation of breast cancer histopathology in two age groups of women under and above 40 years old. MATERIAL AND METHODS: A cross-sectional study was performed on 64 patients with breast cancer referring to hospitals during 2014 and 2015 years...
March 18, 2024: International Tinnitus Journal
https://read.qxmd.com/read/38506978/partial-accelerated-irradiation-with-stereotactic-radiotherapy-at-a-dose-of-30%C3%A2-gy-in-5%C3%A2-fractions-in-early-breast-cancer
#15
JOURNAL ARTICLE
Javier Albendea Roch, Javier T Anchuelo Latorre, M Piedad Galdós Barroso, P Navarrete Solano, Ana Laura Rivero Pérez, Frandeina Pinto Guevara, Mara García Lamela, Javier Olloqui Urroz, M Díaz de Tuesta, Jesús Mazaira, Pedro Muñoz, Pedro J Prada Gómez
PURPOSE: To evaluate feasibility of accelerated partial breast irradiation (APBI) using stereotactic radiotherapy (SBRT) Thirty Gy delivered in 5 fractions for patients with early breast cancer. METHODS: Between January 1st, 2018, and December 31s, 2022, we conducted 117 treatments for patients with early-stage breast cancer. All patients underwent conservative surgery followed by APBI using stereotactic external beam radiotherapy. We analyzed local, regional, distant control, overall survival, toxicity, and cosmetic outcomes...
March 20, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38503970/breast-tissue-imaging-atlas-using-ultra-fast-confocal-microscopy-to-identify-cancer-lesions
#16
JOURNAL ARTICLE
Marie-Christine Mathieu, Moira Ragazzi, Malek Ferchiou, Paul J van Diest, Odile Casiraghi, Aicha Ben Lakhdar, Nizar Labaied, Angelica Conversano, Muriel Abbaci
New generation ultra-fast fluorescence confocal microscopy (UFCM) allows to image histological architecture of fresh breast tissue and may be used for ex vivo intraoperative analysis for margin status. The criteria to identify breast tumoral and non-tumoral tissues in UFCM images are still objects of investigation. The objective of the study was to create an atlas of ex vivo UFCM images of breast tissues and breast carcinomas based on the first extensive collection of large field-of-view UFCM breast images...
March 19, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38500348/rare-presentation-of-papillary-carcinoma-within-a-sentinel-lymph-node-in-a-patient-with-ductal-carcinoma-in-situ-of-the-breast-a-challenging-but-useful-case-report-discussion-regarding-displacement-or-true-metastasis
#17
JOURNAL ARTICLE
Fnu Sonam, Miglena K Komforti, James W Jakub, Lauren F Cornell, Kristin A Robinson
Papillary carcinoma of the breast is a rare histologic subtype of invasive breast cancer. In contrast, ductal carcinoma in situ (DCIS) is a noninvasive, nonobligate precursor to invasive mammary carcinoma, confined within the terminal duct lobular unit of the breast and surrounded by an intact myoepithelial cell layer at the stromal/epithelial interface. We present an unusual case in which a patient with only DCIS of the breast exhibited papillary carcinoma within a sentinel lymph node, leading to questions about the origin of the lymph node lesion-whether it represents a true metastasis or iatrogenic displacement during diagnostic procedures...
March 18, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38497796/surgical-outcomes-of-total-duct-excision-in-the-diagnosis-and-management-of-nipple-discharge
#18
JOURNAL ARTICLE
K Ward, G Selvarajah, H Al-Omishy, M Sait, H N Khan, K McEvoy, S Robertson
INTRODUCTION: Total duct excision (TDE) is performed for the diagnosis and management of nipple discharge. The Association of Breast Surgery's recent guidelines recommend considering diagnostic surgery for single-duct, blood-stained or clear nipple discharge, and for symptomatic management. METHODS: We retrospectively reviewed the diagnostic and surgical outcomes of all cases of TDE between January 2013 and November 2019. RESULTS: In total, 259 TDEs were carried out: 219 for nipple discharge, 29 for recurrent mastitis, 3 for screening abnormalities and 8 for breast lumps...
March 18, 2024: Annals of the Royal College of Surgeons of England
https://read.qxmd.com/read/38483129/gastric-metastasis-from-breast-cancer-five-cases-and-a-single-institutional-review
#19
JOURNAL ARTICLE
Meng Cheng, Zhanli Jia, Guoyu Zhang, Yingnan Wang, Sainan Li, Shan Yang, Chunxiao Li, Cuizhi Geng
Gastric metastasis from breast cancer has a high rate of misdiagnosis and missed diagnosis. Data of patients who had gastric metastasis from breast cancer were retrieved from our hospital between 2014 and 2020. The gastric metastasis from breast cancer incidence was 0.04% (5/14,169 cases of breast cancer). Four patients had invasive lobular carcinoma, and the other patient had invasive ductal carcinoma. The time from the initial diagnosis of breast cancer to the appearance of gastric metastasis ranged from 0 to 12 years...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38477526/radial-scars-on-screening-digital-breast-tomosynthesis-upstaging-rates-and-management-strategies
#20
JOURNAL ARTICLE
Claire Crowley, Manisha Bahl
Background: Radial scars are more commonly identified on digital breast tomosynthesis (DBT) than on digital mammography (DM). Nonetheless, universal guidelines for radial scar management in the current era of DBT are lacking. Objective: To determine the upstaging rates of screening DBT-detected radial scars with and without atypia and to identify features related to upstaging risk. Methods: This retrospective study included patients who underwent core-needle biopsy (CNB) showing a radial scar after screening DBT and DM from January 1, 2013, to December 31, 2020...
March 13, 2024: AJR. American Journal of Roentgenology
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