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https://www.readbyqxmd.com/read/28917516/impact-of-frailty-on-outcomes-in-patients%C3%A2-undergoing-percutaneous-mitral%C3%A2-valve-repair
#1
Clemens Metze, Anna-Sophie Matzik, Maximilian Scherner, Maria Isabel Körber, Guido Michels, Stephan Baldus, Volker Rudolph, Roman Pfister
OBJECTIVES: The aim of this study was to describe the impact of frailty in patients undergoing percutaneous mitral valve repair (PMVR). BACKGROUND: Frailty is common in elderly patients and those with comorbidities and is associated with adverse prognosis. METHODS: Frailty according to the Fried criteria was assessed in consecutive patients admitted for PMVR. Associations of frailty with 6-week (device success, changes in 6-minute walking distance and Minnesota Living With Heart Failure Questionnaire and Short Form 36 physical and mental component scores, and improvement ≥1 New York Heart Association functional class) and long-term outcomes during a median follow-up period of 429 days were examined...
September 8, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28917513/frail-elderly-the-ideal-patients-for%C3%A2-mitraclip
#2
EDITORIAL
Suzanne V Arnold
No abstract text is available yet for this article.
September 8, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28916345/is-a-technetium-99m-macroaggregated-albumin-scan-essential-in-the-workup-for-selective-internal-radiation-therapy-with-yttrium-90-an-analysis-of-532-patients
#3
Lidia Sancho, Macarena Rodriguez-Fraile, Jose Ignacio Bilbao, Carmen Beorlegui Arteta, Mercedes Iñarrairaegui, Veronica Moran, Bruno Sangro
PURPOSE: To determine if baseline patient, tumor, and pretreatment evaluation characteristics could help identify patients who require technetium-99m ((99m)Tc) macroaggregated albumin ((99m)Tc MAA) imaging before selective internal radiation therapy (SIRT). MATERIALS AND METHODS: In this retrospective analysis, 532 consecutive patients with primary (n = 248) or metastatic (n = 284) liver tumors were evaluated between 2006 and 2015. Variables were compared between patients in whom (99m)Tc MAA imaging results contraindicated/modified SIRT administration with yttrium-90 ((90)Y) resin microspheres and those who were treated as initially planned...
September 13, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28914718/balance-evaluation-of-prefrail-and-frail-community-dwelling-older-adults
#4
Larissa Tomasauskas Marques, Natalia Camargo Rodrigues, Emanuella Oliveira Angeluni, Fernanda Pinheiro Amador Dos Santos Pessanha, Natália Maira da Cruz Alves, Renato Campos Freire Júnior, Eduardo Ferriolli, Daniela Cristina Carvalho de Abreu
BACKGROUND AND PURPOSE: With the increase in the percentage of the population in older adulthood, issues such as frailty syndrome need to be considered. The aim of the present study was to evaluate the ability of the Balance Evaluation Systems Test (BESTest) and center of pressure (COP) in their ability to discriminate between nonfrail, prefrail, and frail older adults. The proposed hypothesis is that frail older adults would show poorer performance in BESTest tasks and higher oscillation of COP on a force platform...
September 13, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28914661/percutaneous-aortic-leak-closure-in-a-small-and-frail-annulus-after-double-heart-valve-replacement
#5
Guglielmo Saitto, Paolo Nardi, Gian P Ussia, Domenico Sergi, Paolo Prati, Marco Russo, Francesco Romeo, Giovanni Ruvolo
: Paravalvular leak (PVL) is an uncommon but serious complication associated with the implantation of prosthetic valves. Following aortic valve replacement, up to 5% of patients affected by PVL develop clinical symptoms of heart failure, hemolysis or both. Percutaneous treatment of PVL has emerged instead of conventional surgery, as a well tolerated and less invasive procedure but remains a challenge. We present the case of a young woman with mechanical aortic and mitral prostheses, who presented surgical aortic PVL caused by a serious frailty of native annulus, became symptomatic after 5 months and was successfully percutaneously treated with an Amplatzer Duct Occluder device...
September 12, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28901992/european-guidelines-on-perioperative-venous-thromboembolism-prophylaxis-surgery-in-the-elderly
#6
Sibylle Kozek-Langenecker, Christian Fenger-Eriksen, Emmanuel Thienpont, Giedrius Barauskas
: The risk for postoperative venous thromboembolism (VTE) is increased in patients aged more than 70 years and in elderly patients presenting with co-morbidities, for example cardiovascular disorders, malignancy or renal insufficiency. Therefore, risk stratification, correction of modifiable risks and sustained perioperative thromboprophylaxis are essential in this patient population. Timing and dosing of pharmacoprophylaxis may be adopted from the non-aged population. Direct oral anti-coagulants are effective and well tolerated in the elderly; statins may not replace pharmacological thromboprophylaxis...
September 9, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28899661/frailty-polypharmacy-and-health-outcomes-in-older-adults-the%C3%A2-frailty-and-dependence-in-albacete-study
#7
Bonaga Beatriz, Pedro M Sánchez-Jurado, Marta Martínez-Reig, Gabriel Ariza, Leocadio Rodríguez-Mañas, Danijela Gnjidic, Tránsito Salvador, Pedro Abizanda
BACKGROUND/OBJECTIVES: To investigate if polypharmacy modifies the association between frailty and health outcomes in older adults. DESIGN: Ongoing cohort study. SETTING: Albacete City, Spain. PARTICIPANTS: A total for 773 participants, 457 women (59.1%), over age 70 years from the FRADEA Study. MEASUREMENTS: Frailty phenotype, polypharmacy considered as the chronic use of 5 or more drugs, and comorbidity were collected at the baseline visit...
September 9, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28899369/nursing-care-needs-and-services-utilised-by-home-dwelling-elderly-with-complex-health-problems-observational-study
#8
Gro Næss, Marit Kirkevold, Wenche Hammer, Jørund Straand, Torgeir Bruun Wyller
BACKGROUND: In Norway, as in many Western countries, a shift from institutional care to home care is taking place. Our knowledge is limited regarding which needs for nursing interventions patients being cared for in their home have, and how they are met. We aimed at assessing aspects of health and function in a representative sample of the most vulnerable home-dwelling elderly, to identify their needs for nursing interventions and how these needs were met. METHODS: In this observational study we included patients aged 75+ living in their own homes in Oslo, who received daily home care, had three or more chronic diagnoses, received daily medication, and had been hospitalized during the last year...
September 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28895175/the-use-of-case-management-for-community-dwelling-older-people-the-effects-on-loneliness-symptoms-of-depression-and-life-satisfaction-in-a-randomised-controlled-trial
#9
Elin Taube, Jimmie Kristensson, Patrik Midlöv, Ulf Jakobsson
AIM: To investigate the effects of a case management intervention for community-dwelling frail older people, with functional dependency and repeated contacts with the healthcare services, focusing on loneliness, depressive symptoms and life satisfaction. DESIGN: A two-armed, nonblinded, randomised control trial with repeated follow-ups, of N = 153 participants at baseline allocated to an intervention (n = 80) and control (n = 73) group. METHOD: Inclusion criteria were the following: ≥65 years of age, living in ordinary housing, in need of assistance in two or more self-reported activities of daily living, having at least two hospital admissions or at least four visits in outpatient care 12 months prior to enrolment...
September 12, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28891202/mechanical-signals-protect-stem-cell-lineage-selection-preserving-the-bone-and-muscle-phenotypes-in-obesity
#10
REVIEW
Danielle M Frechette, Divya Krishnamoorthy, Tee Pamon, M Ete Chan, Vihitaben Patel, Clinton T Rubin
The incidence of obesity is rapidly rising, increasing morbidity and mortality rates worldwide. Associated comorbidities include type 2 diabetes, heart disease, fatty liver disease, and cancer. The impact of excess fat on musculoskeletal health is still unclear, although it is associated with increased fracture risk and a decline in muscular function. The complexity of obesity makes understanding the etiology of bone and muscle abnormalities difficult. Exercise is an effective and commonly prescribed nonpharmacological treatment option, but it can be difficult or unsafe for the frail, elderly, and morbidly obese...
September 11, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28890975/thiol-ene-oxidation-tandem-reaction-under-visible-light-photocatalysis-synthesis-of-alkyl-sulfoxides
#11
Andrea Guerrero-Corella, Ana María Martinez-Gualda, Fereshteh Ahmadi, Enrique Ming, Alberto Fraile, José Alemán
The photocatalyzed synthesis of sulfoxides from alkenes and thiols has been carried out using Eosin Y. This is a metal-free method which uses a low catalyst loading, atmospheric oxygen as the oxidant, and visible light conditions (green light). A mechanism has been proposed that is consistent with the experimental results.
September 11, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28888718/the-frail-fail-increased-mortality-and-post-operative-complications-in-orthopaedic-trauma-patients
#12
CatPhuong Cathy L Vu, Robert P Runner, William M Reisman, Mara L Schenker
OBJECTIVE: The burgeoning elderly population calls for a robust tool to identify patients with increased risk of mortality and morbidity. This paper investigates the utility of the MFI as a predictor of morbidity and mortality in orthopaedic trauma patients. DESIGN: Retrospective review of the NSQIP database to identify patients age 60 and above who underwent surgery for pelvis and lower extremity fractures between 2005 and 2014. MAIN OUTCOMES AND MEASURES: For each patient, an MFI score was calculated using NSQIP variables...
August 18, 2017: Injury
https://www.readbyqxmd.com/read/28888554/how-to-treat-pancreatic-adenocarcinoma-in-elderly-how-far-can-we-go-in-2017
#13
REVIEW
Marine Gilabert, Jean Luc Raoul, Frederique Rousseau
Pancreatic adenocarcinoma is one of the most fatal cancers that frequently affects older patients. Limited data suggest that older patients are as likely to benefit from surgery, radiation, and chemotherapy as younger patients. The only potentially curative approach for pancreatic cancer is surgery but this is only performed in less than 20% of patients considered resectable. With improvements in surgical techniques, older patients without major comorbidities show a course of disease after resection similar to that of younger patients...
September 6, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28888205/measuring-geomorphological-vulnerability-on-beaches-using-a-set-of-indicators-gvi-a-tool-for-management
#14
Carolina Peña-Alonso, Pablo Fraile-Jurado, Luis Hernández-Calvento, Emma Pérez-Chacón, Eduard Ariza
A system of indicators has been developed to evaluate beach geomorphological vulnerability (GVI) through: intrinsic susceptibility, the agents that model them, and their ability to remain stable over time. The method is applied to 34 beaches on the island of Gran Canaria (Spain) that experience different levels and conditions of human occupation, marine incidence, landforms and sediments, and spatial evolution that have been recorded since 1960. In contrast with other studies, the analysis of these dimensions (and their relationships) allows a diagnosis of the geomorphology of the beaches with an integrated approach...
September 6, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28887286/why-does-the-health-related-quality-of-life-in-idiopathic-normal-pressure-hydrocephalus-fail-to-improve-despite-the-favorable-clinical-outcome
#15
Junkkari Antti, Roine Risto P, Luikku Antti, Rauramaa Tuomas, Sintonen Harri, Nerg Ossi, Koivisto Anne M, Häyrinen Antti, Viinamäki Heimo, Soininen Hilkka, Jääskeläinen Juha E, Leinonen Ville
OBJECTIVE: Occasionally a favorable clinical disease-specific outcome does not reflect into improved generic health-related quality of life (HRQoL) in patients with idiopathic normal pressure hydrocephalus (iNPH) one year after the installation of the cerebrospinal fluid (CSF) shunt. Our aim was to identify factors causing this discrepancy. METHODS: The one-year HRQoL outcome of 141 iNPH patients was evaluated using the generic 15D instrument, in which the minimum clinically important change/difference on the 0-1 scale has been estimated to be ± 0...
September 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28887242/rapid-methods-for-routine-frailty-assessment-during-vascular-surgery-clinic-visits
#16
Luke G Mirabelli, Robert M Cosker, Larry W Kraiss, Claire L Griffin, Brigitte K Smith, Mark R Sarfati, Ragheed Al-Dulaimi, Benjamin S Brooke
BACKGROUND: Frailty assessment can help vascular surgeons predict perioperative risk and long term mortality for their patients. Unfortunately, comprehensive frailty assessments take too long to integrate into clinic workflow. This study was designed to evaluate 2 rapid methods for assessing frailty during vascular clinics-a short patient-reported survey and a provider-reported frailty scale. METHODS: We prospectively enrolled 159 patients presenting to an academic medical center vascular surgery clinic between May-November 2016...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28885763/the-maastricht-frailty-screening-tool-for-hospitalised-patients-mfst-hp-to-identify-non-frail-patients
#17
Ron M J Warnier, Erik van Rossum, Sander M J van Kuijk, Wubbo J Mulder, Jos M G A Schols, Gertrudis I J M Kempen
BACKGROUND: The Maastricht frailty screening tool for hospitalised patients (MFST-HP) is a frailty screening tool that is fully integrated in the nursing assessment at admission. This study aims to determine the predictive value of the MFST-HP for the health outcomes length of hospital stay, discharge destination, readmission and mortality. METHODS: Data of 2691 hospitalised patients (70+), admitted between 01-01-2013 and 31-12-2013, were included in the study. The predictive value of the MFST-HP was analysed by means of receiver operating characteristics curves...
September 8, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28885489/frailty-and-postkidney-transplant-health-related-quality-of-life
#18
Mara A McAdams-DeMarco, Israel O Olorundare, Hao Ying, Fatima Warsame, Christine E Haugen, Rasheeda Hall, Jacqueline M Garonzik-Wang, Niraj M Desai, Jeremy D Walston, Silas P Norman, Dorry L Segev
BACKGROUND: HRQOL reflects a patient's disease burden, treatment effectiveness, and health status and is summarized by physical, mental, and kidney disease-specific scales among ESRD patients. While on average HRQOL improves post-KT, the degree of change depends on the ability of the patient to withstand the stressor of dialysis versus the ability to tolerate the intense physiologic changes of KT. Frail KT recipients may be extra vulnerable to either of these stressors, thus affecting change in HRQOL after KT...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28884787/ultrasonic-echo-intensity-as-a-new-noninvasive-in-vivo-biomarker-of-frailty
#19
Rebeca Mirón Mombiela, Fernando Facal de Castro, Pilar Moreno, Consuelo Borras
OBJECTIVES: To investigate whether muscle quality based on echo intensity (EI) is associated with muscle strength (MS) and correlates with risk of frailty in elderly outpatients. DESIGN: Cross-sectional, experimental study. SETTING: Outpatient clinic. PARTICIPANTS: Individuals aged 20 to 90 (N = 112). Individuals aged 20 to 59 participated as controls. Those aged 60 and older participated in the experimental group and were subdivided into robust, prefrail, and frail according to the Fried frailty criteria...
September 7, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28883929/frailty-and-patient-reported-outcomes-in-subjects-with-chronic-obstructive-pulmonary-disease-are-they-independent-entities
#20
Masaaki Kusunose, Toru Oga, Saya Nakamura, Yoshinori Hasegawa, Koichi Nishimura
INTRODUCTION: There is a hypothesis that chronic obstructive pulmonary disease (COPD) is an accelerated ageing disease. Frailty is a geriatric syndrome characterised by physical, psychological and social vulnerability, thought to be a feature of ageing. The authors aimed to explore the relationship between frailty and physiological and patient-reported outcomes (PROs) in subjects with stable COPD. METHODS: We administered the Kihon Checklist that has been validated for frailty screening...
2017: BMJ Open Respiratory Research
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