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Hypophosphatemia

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https://www.readbyqxmd.com/read/29664498/-hypophosphatemia-in-preterm-infants-a-bimodal-disorder
#1
María Paz Cubillos Celis, Patricia Mena Nannig
New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29660779/clinical-findings-and-diagnostic-procedures-in-270-small-ruminants-with-obstructive-urolithiasis
#2
Anna-Katharina Riedi, Gabriela Knubben-Schweizer, Mireille Meylan
BACKGROUND: Details of the clinical signs of obstructive urolithiasis in male small ruminants have not been documented in a large population. OBJECTIVE: To describe the clinical presentation and diagnostic procedures in a large group of small ruminants with urolithiasis. ANIMALS: Two hundred and seventy small ruminants (158 sheep and 112 goats). METHODS: Retrospective study of 270 cases identified based on clinical records...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29614569/-relationship-between-continuous-renal-replacement-therapy-and-hypophosphatemia-in-critically-ill-children
#3
T Sun, Y Q Ren, F Wang, H J Miao, Y J Shan, C X Wang, Y C Zhang
Objective: To investigate the incidence and prognosis of hypophosphatemia in critically ill children treated with continuous blood purification (CBP). Methods: The medical records of the critically ill patients, who were treated with CBP, admitted to pediatric intensive care unit (PICU) of Shanghai Children's Hospital from May 2014 to April 2017 were retrospectively analyzed. The serum phosphorus levels were tested before CBP, at 48-72 h during CBP, at the end of CBP and on the next day after CBP finished. Phosphorus supplement was given to the children with severe hypophosphatemia...
April 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29610453/sj%C3%A3-gren-s-syndrome-associated-with-fanconi-s-syndrome-and-osteomalacia
#4
Jorge O Gutierrez, Maria F Zurita, Luis A Zurita
BACKGROUND Sjögren's syndrome is a chronic inflammatory autoimmune disease, which is also known as sicca syndrome, due to the symptoms of dry eyes and dry mouth, and is associated with other connective tissue diseases and autoimmune diseases. Sjögren's syndrome can also be associated with renal involvement. Fanconi's syndrome is associated with impaired reabsorption in the proximal renal tubule associated with tubulointerstitial nephritis and is associated with renal tubular acidosis and hypophosphatemia...
April 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29603593/phase-i-trial-of-the-mtor-inhibitor-everolimus-in-combination-with-multi-agent-chemotherapy-in-relapsed-childhood-acute-lymphoblastic-leukemia
#5
Andrew E Place, Yana Pikman, Kristen E Stevenson, Marian H Harris, Melinda Pauly, Maria-Luisa Sulis, Nobuko Hijiya, Lia Gore, Todd M Cooper, Mignon L Loh, Giovanni Roti, Donna S Neuberg, Sarah K Hunt, Sarah Orloff-Parry, Kimberly Stegmaier, Stephen E Sallan, Lewis B Silverman
BACKGROUND: We sought to determine the feasibility of co-administering everolimus with a four-drug reinduction in children and adolescents with acute lymphoblastic leukemia (ALL) experiencing a first marrow relapse. PROCEDURE: This phase I study tested everolimus with vincristine, prednisone, pegaspargase and doxorubicin in patients with marrow relapse occurring >18 months after first complete remission (CR). The primary aim was to identify the maximum tolerated dose of everolimus...
March 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29599748/polyostotic-fibrous-dysplasia-with-and-without-mccune-albright-syndrome-clinical-features-in-a-nordic-pediatric-cohort
#6
Pauliina Utriainen, Helena Valta, Sigridur Björnsdottir, Outi Mäkitie, Eva Horemuzova
Objective: Fibrous dysplasia (FD) presents as skeletal lesions in which normal bone is replaced by abnormal fibrous tissue due to mosaic GNAS mutation. McCune-Albright syndrome (MAS) refers to FD combined with skin (café-au-lait) and endocrine manifestations. This study describes the clinical childhood manifestations of polyostotic FD and MAS in a Nordic cohort. Patients and design: We retrospectively reviewed a cohort of pediatric patients ( n  = 16) with polyostotic FD with or without MAS diagnosed and followed in two Nordic Pediatric tertiary clinics between 1996 and 2017...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29593193/hypophosphatemia-occurs-with-insulin-administration-during-refeeding-by-total-parenteral-nutrition-in-rats
#7
Hiromi Kawamura, Sarasa Tanaka, Yuri Uenami, Mariko Tani, Midori Ishitani, Saeko Morii, Motoyoshi Sakaue, Mikiko Ito
Refeeding syndrome (RFS) is characterized by the metabolic and clinical changes that occur following aggressive nutritional supplementation in malnourished patients. Hypophosphatemia is the hallmark of RFS and is key to its prevention and treatment in clinical practice. However, the mechanism of hypophosphatemia during RFS is unclear because of the lack of an animal model. In this study, we developed a rat RFS model as a first step to clarifying the molecular mechanism. After establishing the parenteral route, rats were fasted for 5 days and refeeding was started using total parenteral nutrition...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29581918/steroids-and-thyrotoxicosis-precipitate-periodic-paralysis
#8
Rizwan Ahamed, Sarah McCalley, Anupam A Sule
Thyrotoxic Periodic Paralysis (TPP) belongs to a group of muscle diseases called channelopathies, which present with painless generalized muscle weakness without exertion. TPP can be precipitated by a large carbohydrate meal, stress, strenuous exercise, alcohol, a high-salt diet, menstruation, and cold temperatures. Rarely, steroids such as dexamethasone can also precipitate a TPP attack. A 29-year-old Hispanic male, with a history of hyperthyroidism, presented to the emergency department with progressive weakness, predominantly in the lower extremities since morning...
January 23, 2018: Curēus
https://www.readbyqxmd.com/read/29575761/osteomalacia-due-to-drug-induced-fanconi-syndrome
#9
Jiacai Cho, Peter P Cheung
The patient, a 70-year-old man, presented with bilateral deep knee pain and myalgia for a year. Ten years ago, he was started on adefovir 10mg daily for hepatitis B. He was also on metformin for diabetes mellitus. Examination revealed mild bilateral patellofemoral crepitus and proximal myopathy. Laboratory investigations showed a raised alkaline phosphatase of 449 U/L (40-130 U/L) and hypophosphatemia of 1.5mg/dL (2.6-4.5mg/dL). This article is protected by copyright. All rights reserved.
March 25, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29575544/adverse-reactions-of-sorafenib-sunitinib-and-imatinib-in-treating-digestive-system-tumors
#10
Yali Fu, Xing Wei, Li Lin, Weiran Xu, Jun Liang
BACKGROUND: This study was conducted to assess the adverse reactions caused by multi-target tyrosine kinase inhibitor treatment of gastrointestinal tumors. METHODS: We carried out a retrospective study of drug-related adverse reactions in 115 patients who were treated with sorafenib, sunitinib, and imatinib for primary hepatocellular carcinoma or gastrointestinal stromal tumors from October 2003 to March 2012 at the Peking University International Hospital. RESULTS: The total incidence of adverse reactions of sorafenib, sunitinib, and imatinib in patients with hepatocellular carcinoma and gastrointestinal stromal tumors was > 80%...
March 25, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29572937/suitability-of-oral-administration-of-monosodium-phosphate-disodium-phosphate-and-magnesium-phosphate-for-the-rapid-correction-of-hypophosphatemia-in-cattle
#11
Imke Cohrs, Walter Grünberg
BACKGROUND: Hypophosphatemia is commonly associated with disease and decreased productivity in dairy cows particularly in early lactation. Oral supplementation with phosphate salts is recognized as suitable for the rapid correction of hypophosphatemia. Little information is available about the differences in efficacy between salts used for oral phosphorus supplementation. OBJECTIVES: Comparison of efficacy of oral administration of NaH2 PO4 , Na2 HPO4 , and MgHPO4 in treating hypophosphatemia in cattle...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29571670/maxillary-tumour-induced-osteomalacia
#12
O Emodi, A Rachmiel, D Tiosano, R M Nagler
Tumour-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, defective vitamin D metabolism, and osteomalacia. In the case reported here, maxillary TIO was not diagnosed for 6years, although initial complaints were reported when the patient was 12years old. Meanwhile she suffered from profound growth limitation, pain, weakness, and spontaneous multiple bone fractures, culminating in complete loss of ambulatory ability and severe limitation in daily activities...
March 20, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29551559/phase-i-trial-of-anti-met-monoclonal-antibody-in-met-overexpressed-refractory-cancer
#13
Jeeyun Lee, Seung Tae Kim, Sungju Park, Sujin Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Hongmo Ahn, Haesook Bok, Kyoung-Mee Kim, Myung Ju Ahn, Won Ki Kang, Young Suk Park
BACKGROUND: Samsung Advance Institute of Technology-301 (SAIT301) is a human immunoglobulin G2 antibody that can specifically target mesenchymal epithelial transition factor (c-MET). This novel antibody has higher priority over hepatocyte growth factors when binding to the Sema domain of c-MET and accelerates the internalization and degradation of c-MET, proving its powerful antitumor activities in intra- as well as extracellular areas. MATERIALS AND METHODS: SAIT301 was administered intravenously once every 3 weeks in c-MET overexpressed solid tumor patients, focusing on metastatic colorectal cancer (CRC) according to common clinical phase I criteria...
January 31, 2018: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29526946/a-retrospective-study-on-the-epidemiological-and-clinical-features-of-emergency-patients-with-large-or-massive-consumption-of-caffeinated-supplements-or-energy-drinks-in-japan
#14
Yoshito Kamijo, Michiko Takai, Yuji Fujita, Kiyotaka Usui
Objective We conducted a retrospective study on the epidemiological and clinical features of patients with acute caffeine poisoning in Japan. Methods Letters requesting participation were sent to 264 emergency departments of hospitals, and questionnaires were mailed to those that agreed to participate. Patients Participants were patients transported to emergency departments of hospitals between April 2011 and March 2016 after consuming large or massive amounts of caffeinated supplements and/or energy drinks (caffeine dose ≥1...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29520435/a-phase-i-trial-of-escalating-doses-of-cixutumumab-imc-a12-and-sorafenib-in-the-treatment-of-advanced-hepatocellular-carcinoma
#15
Anthony B El-Khoueiry, Robert O'Donnell, Thomas J Semrad, Philip Mack, Suzette Blanchard, Nathan Bahary, Yixing Jiang, Yun Yen, John Wright, Helen Chen, Heinz-Josef Lenz, David R Gandara
PURPOSE: The insulin-like growth factor (IGF) pathway is activated in hepatocarcinogenesis. Cixutumumab is a monoclonal antibody against human insulin-like growth factor-1 receptor (IGF-1R). Given the cross-talk between the IGF and VEGF pathways, we performed a phase I study of the combination of cixutumumab and sorafenib in hepatocellular cancer (HCC). METHODS: Eligible patients with no prior systemic therapy for advanced HCC and Child-Pugh A to B7 were treated with sorafenib 400 mg BID and escalating doses of cixutumumab (2, 4, or 6 mg/kg IV weekly) in a 3 + 3 design...
March 8, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29519205/impact-of-serum-phosphate-in-mechanically-ventilated-patients-with-severe-sepsis-and-septic-shock
#16
Christopher J Miller, Bruce A Doepker, Andrew N Springer, Matthew C Exline, Gary Phillips, Claire V Murphy
BACKGROUND: Hypo- and hyperphosphatemia are common in severe sepsis and septic shock. Published outcome data in patients with phosphate derangements primarily focus on hypophosphatemia and the general critically ill population. This study aimed to determine the impact of serum phosphate on clinical outcomes in patients with severe sepsis and septic shock. METHODS: A retrospective cohort analysis of adult mechanically ventilated patients with severe sepsis or septic shock was performed...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29515412/acute-lymphoblastic-leukemia-presenting-as-fanconi-syndrome
#17
Tatsunori Yoshida, Hiroshi Tsujimoto, Takayuki Ichikawa, Shinji Kounami, Hiroyuki Suzuki
Acute lymphoblastic leukemia (ALL) presenting as Fanconi syndrome (FS) is extremely rare. Here, we report a case of ALL presenting as bilateral nephromegaly following FS. A 2-year-old girl was unexpectedly diagnosed with bilateral nephromegaly. After 2 weeks, she developed general fatigue, thirst, and polyuria. Laboratory examinations revealed renal tubular acidosis, hypokalemia, hypophosphatemia, and aminoaciduria, and FS was diagnosed. Replacement of bicarbonate and potassium did not improve her condition...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29505567/clinical-and-genetic-characteristics-of-15-families-with-hereditary-hypophosphatemia-novel-mutations-in-phex-and-slc34a3
#18
Sezer Acar, Huda A BinEssa, Korcan Demir, Roua A Al-Rijjal, Minjing Zou, Gönül Çatli, Ahmet Anık, Anwar F Al-Enezi, Seçil Özışık, Manar S A Al-Faham, Ayhan Abacı, Bumin Dündar, Walaa E Kattan, Maysoon Alsagob, Salih Kavukçu, Hamdi E Tamimi, Brian F Meyer, Ece Böber, Yufei Shi
BACKGROUND: Hereditary hypophosphatemia is a group of rare renal phosphate wasting disorders. The diagnosis is based on clinical, radiological, and biochemical features, and may require genetic testing to be confirmed. METHODOLOGY: Clinical features and mutation spectrum were investigated in patients with hereditary hypophosphatemia. Genomic DNA of 23 patients from 15 unrelated families were screened sequentially by PCR-sequencing analysis for mutations in the following genes: PHEX, FGF23, DMP1, ENPP1, CLCN5, SLC34A3 and SLC34A1...
2018: PloS One
https://www.readbyqxmd.com/read/29502359/fgf23-neutralizing-antibody-partially-improves-bone-mineralization-defect-of-hmwfgf2-isoforms-transgenic-female-mice
#19
Liping Xiao, Collin Homer-Bouthiette, Marja M Hurley
Mice overexpressing high molecular weight FGF2 isoforms (HMWTg) in osteoblast lineage phenocopy human X-linked hypophosphatemic rickets (XLH) and Hyp murine model of XLH demonstrating increased FGF23/FGF receptor signaling and hypophosphatemic rickets/osteomalacia. Since HMWFGF2 was up-regulated in bones of Hyp mice and abnormal FGF23 signaling is important in XLH, HMWTg mice were used to examine the effect of the FGF23 neutralizing antibody (FGF23Ab). Eight-week-old female Vector control mice and HMWTg mice were treated with FGF23Ab or control IgG...
March 4, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29480626/oral-stomatitis-and-mtor-inhibitors-a-review-of-current-evidence-in-20-915-patients
#20
L Lo Muzio, C Arena, G Troiano, A Villa
BACKGROUND: Traditional treatment of malignancies with chemotherapeutic agents is often affected by the damage inflicted on non-cancerous cells. Toxicities of the oral cavity, such as mucositis and stomatitis, are some of the most significant and unavoidable toxicities associated with anti-cancer therapies. For such reason, in the last decades, newer targeted agents have been developed aiming to decrease the rates of side effects on healthy cells. Unfortunately, targeted anti-cancer therapies also showed significant rate of toxicity on healthy tissues...
March 2018: Oral Diseases
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