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https://www.readbyqxmd.com/read/29054476/extracellular-vesicles-as-emerging-targets-in-cancer-recent-development-from-bench-to-bedside
#1
REVIEW
Kerui Wu, Fei Xing, Shih-Ying Wu, Kounosuke Watabe
Extracellular vesicles (EVs) have emerged as important players of cancer initiation and progression through cell-cell communication. They have been recognized as critical mediators of extracellular communications, which promote transformation, growth invasion, and drug-resistance of cancer cells. Interestingly, the secretion and uptake of EVs are regulated in a more controlled manner than previously anticipated. EVs are classified into three groups, (i) exosomes, (ii) microvesicles (MVs), and (iii) apoptotic bodies (ABs), based on their sizes and origins, and novel technologies to isolate and distinguish these EVs are evolving...
October 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29054369/exosome-is-a-mechanism-of-intercellular-drug-transfer-application-of-quantitative-pharmacology
#2
Jin Wang, Bertrand Z Yeung, Minjian Cui, Cody J Peer, Ze Lu, William D Figg, M Guillaume Wientjes, Sukyung Woo, Jessie L-S Au
PURPOSE: Exosomes are small membrane vesicles (30-100nm in diameter) secreted by cells into extracellular space. The present study evaluated the effect of chemotherapeutic agents on exosome production and/or release, and quantified the contribution of exosomes to intercellular drug transfer and pharmacodynamics. METHODS: Human cancer cells (breast MCF7, breast-to-lung metastatic LM2, ovarian A2780 and OVCAR4) were treated with paclitaxel (PTX, 2-1000nM) or doxorubicin (DOX, 20-1000nM) for 24-48h...
October 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29054268/saliva-exosomics-in-cancer-molecular-characterization-of-cancer-derived-exosomes-in-saliva
#3
Taichiro Nonaka, David T W Wong
Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells and detected in saliva. Pathophysiological roles for salivary exosomes are beginning to be recognized in diseases including cancer, highlighting potential biomarkers and biological functions. Since early detection of cancer is vital for successful treatment, salivary exosomes would be advantageous in achieving a better survival rate due to their ready availability and noninvasiveness. The use of salivary exosomes may therefore be promising in the accurate detection of premalignant lesions and early-stage cancers, also for better our understanding of the molecular basis of tumorigenesis...
2017: Enzymes
https://www.readbyqxmd.com/read/29053921/integrated-kidney-exosome-analysis-ikea-for-the-detection-of-kidney-transplant-rejection
#4
Jongmin Park, Hsing-Ying Lin, Jean Pierre Assaker, Sangmoo Jeong, Chen-Han Huang, Ahmed Kurdi, Kyungheon Lee, Kyle Fraser, Changwook Min, Siawosh Eskandari, Sujit Routray, Bakhos A Tannous, Reza Abdi, Leonardo Riella, Anil Chandraker, Cesar M Castro, Ralph Weissleder, Hakho Lee, Jamil R Azzi
Kidney transplant patients require life-long surveillance to detect allograft rejection. Repeated biopsy, albeit the clinical gold standard, is an invasive procedure with the risk of complications and comparatively high cost. Conversely, serum creatinine or urinary proteins are non-invasive alternatives, but are late markers with low specificity. We here report a new urine-based platform to detect kidney transplant rejection. Termed iKEA (integrated kidney exosome analysis), the approach detects extracellular vesicles (EVs) released by immune cells into urine; we reasoned that T cells, attacking kidney allografts, would shed EVs, which in turn can be used as surrogate marker for inflammation...
October 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29053009/plasma-exosomes-disrupt-blood-brain-barrier-in-children-with-osa-and-neurocognitive-deficits
#5
Abdelnaby Khalyfa, David Gozal, Leila Kheirandish-Gozal
No abstract text is available yet for this article.
October 20, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29051321/liquid-biopsies-using-plasma-exosomal-nucleic-acids-and-plasma-cell-free-dna-compared-with-clinical-outcomes-of-patients-with-advanced-cancers
#6
Lino Möhrmann, Helen Huang, David S Hong, Apostolia M Tsimberidou, Siqing Fu, Sarina Piha-Paul, Vivek Subbiah, Daniel D Karp, Aung Naing, Anne K Krug, Daniel Enderle, Tina Priewasser, Mikkel Noerholm, Erez Eitan, Christine Coticchia, Georg Stoll, Lisa-Marie Jordan, Cathy Eng, Scott Kopetz, Johan Skog, Funda Meric-Bernstam, Filip Janku
PURPOSE: Blood-based liquid biopsies offer easy access to genomic material for molecular diagnostics in cancer. Commonly used cell-free DNA (cfDNA) originates from dying cells. Exosomal nucleic acids (exoNA) originate from living cells, which can better reflect underlying cancer biology. EXPERIMENTAL DESIGN: Next-generation sequencing (NGS) was used to test exosomal nucleic acids (exoNA), and droplet digital PCR (ddPCR) and BEAMing PCR were used to test cfDNA for BRAF V600, KRAS G12/G13, and EGFR exon19del/L858R mutations in 43 patients with progressing advanced cancers...
October 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29050313/adipose-derived-mesenchymal-stem-cells-employed-exosomes-to-attenuate-aki-ckd-transition-through-tubular-epithelial-cell-dependent-sox9-activation
#7
Fengming Zhu, Octavia L S Chong Lee Shin, Guangchang Pei, Zhizhi Hu, Juan Yang, Han Zhu, Meng Wang, Jingyi Mou, Jie Sun, Yuxi Wang, Qian Yang, Zhi Zhao, Huzi Xu, Hui Gao, Weiqi Yao, Xiao Luo, Wenhui Liao, Gang Xu, Rui Zeng, Ying Yao
Acute kidney injury (AKI) predisposes patients to an increased risk into progressive chronic kidney disease (CKD), however effective treatments are still elusive. This study aimed to investigate the therapeutic efficacy of human adipose-derived MSCs (hAD-MSCs) in the prevention of AKI-CKD transition, and illuminate the role of Sox9, a vital transcription factor in the development of kidney, in this process. C57BL/6 mice were subjected to unilateral renal ischemia/reperfusion (I/R) with or without hAD-MSC treatment...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050258/the-diagnostic-prognostic-potential-and-molecular-functions-of-long-non-coding-rnas-in-the-exosomes-derived-from-the-bile-of-human-cholangiocarcinoma
#8
Xianxiu Ge, Youli Wang, Junjie Nie, Quanpeng Li, Lingyu Tang, Xueting Deng, Fei Wang, Boming Xu, Xiaochao Wu, Xiuhua Zhang, Qiang You, Lin Miao
Cholangiocarcinoma (CCA) is an aggressive malignancy associated with unfavorable prognosis, and it's difficult to diagnose and no effective treatments are available. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and metastasis. Intact lncRNAs from exosomes have sparked much interest as potential biomarker for the non-invasive analysis of disease. Here, via exosome sequencing on lncRNAs, GO analysis, KEGG pathway and co-expression analysis, receiver operating characteristic curve and survival analyses, we found that, compared with control group, lncRNAs of ENST00000588480...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050253/differential-expression-of-exosomal-mirnas-between-breast-cancer-patients-with-and-without-recurrence
#9
Aiko Sueta, Yutaka Yamamoto, Mai Tomiguchi, Takashi Takeshita, Mutsuko Yamamoto-Ibusuki, Hirotaka Iwase
BACKGROUND: Exosomal microRNAs (miRNAs) are promising candidate biomarkers for diagnosis or prognosis for breast cancer. We investigated the prognostic role of exosomal miRNAs in serum samples derived from patients with breast cancer and compared miRNA expression between serum and tumor tissues. METHODS: The miRNA profile derived from exosome between breast cancer patients with recurrence (n = 16) and without recurrence (n = 16) were compared by miRNA PCR array...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050192/-advances-in-research-of-exosomes-and-age-related-macular-degeneration
#10
M Q Xu, X D Sun
Exosomes are small vesicles with a molecular diameter of 30 to 100 nm, which are secreted into the cell after the fusion of the multivesicular bodies with the plasma membrane. Exosomes contain various molecular constituents of their cell origin, including proteins, microRNAs and lipids. Different cell-derived exosomes have different biological functions. Exosomes play a very important role in the development and progression of age-related macular degeneration (AMD). The exosomes derived from the eye are involved in the processes of cell growth, metastasis, angiogenesis and immunosuppression by transferring contents to adjacent or distant cells...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29050084/-recent-progress-in-application-of-exosome-in-diagnosis-and-treatment-of-gliomas
#11
W W Xu, L M Wang, L H Teng
No abstract text is available yet for this article.
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29047461/hematopoietic-stem-cell-derived-exosomes-promote-hematopoietic-differentiation-of-mouse-embryonic-stem-cells-in-vitro-via-inhibiting-the-mir126-notch1-pathway
#12
Feng-Ling Liao, Lin Tan, Hua Liu, Jin-Ju Wang, Xiao-Tang Ma, Bin Zhao, Yan-Fang Chen, Ji Bihl, Yi Yang, Ri-Ling Chen
Cell-derived exosomes (EXs) can modulate target cell differentiation via microRNAs (miRs) that they carried. Previous studies have shown that miR126 is highly expressed in hematopoietic stem cells (HSCs) and plays a role in hematopoiesis via modulating the Notch pathway that participates in progenitors' cell fate decisions. In this study we investigated whether HSC-derived EXs (HSC-EXs) could affect the differentiation of mouse embryonic stem cells (ESCs) into HSCs. We prepared HSC-EXs(con), HSC-EXs(sc) and HSC-EXs(miR126) from control HSCs and the HSCs transfected with scramble control or miR126 mimics, respectively...
October 19, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29047044/exosomes-for-the-enhanced-tissue-bioavailability-and-efficacy-of-curcumin
#13
Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish Kumar Agrawal, Ramesh Gupta
Exosomes are extracellular microvesicles with a particle size of 30-100 nm and carry a cargo of proteins, lipids, RNA, and DNA. Their properties of shuttling in-and-out of the cells suggest that these particles can be exploited as a nano drug carrier. In this manuscript, we show that curcumin can be delivered effectively using milk-derived exosomes. Curcumin when mixed with exosomes in the presence of 10% ethanol:acetonitrile (1:1) provided a drug load of 18-24%, and the formulation stored at - 80°C was stable for 6 months as determined by particle size analysis, drug load, and antiproliferative activity...
October 18, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29046875/asymmetric-rna-distribution-among-cells-and-their-secreted-exosomes-biomedical-meaning-and-considerations-on-diagnostic-applications
#14
REVIEW
Marco Ragusa, Cristina Barbagallo, Matilde Cirnigliaro, Rosalia Battaglia, Duilia Brex, Angela Caponnetto, Davide Barbagallo, Cinzia Di Pietro, Michele Purrello
Over the past few years, exosomes and their RNA cargo have been extensively studied because of the fascinating biological roles they play in cell-to-cell communication, including the signal exchange among cancer, stromal, and immune cells, leading to modifications of tumor microenvironment. RNAs, especially miRNAs, stored within exosomes, seem to be among the main determinants of such signaling: their sorting into exosomes appears to be cell-specific and related to cellular physiopathology. Accordingly, the identification of exosomal miRNAs in body fluids from pathological patients has become one of the most promising activity in the field of biomarker discovery...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29046635/mirna-in-circulating-microvesicles-as-biomarkers-for-age-related-cognitive-decline
#15
Asha Rani, Andrew O'Shea, Lara Ianov, Ronald A Cohen, Adam J Woods, Thomas C Foster
Community dwelling older individuals from the North Florida region were examined for health status and a comprehensive neuropsychological battery, including the Montreal Cognitive Assessment (MoCA), was performed on each participant. A subpopulation (58 females and 39 males) met the criteria for age (60-89) and no evidence of mild cognitive impairment, with a MoCA score ≥23. Despite the stringent criteria for participation, MoCA scores were negatively correlated within the limited age range. Extracellular microvesicles were isolated from the plasma and samples were found to be positive for the exosome marker CD63, with an enrichment of particles within the size range for exosomes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29046426/phosphorylation-of-connexin-43-induced-by-traumatic-brain-injury-promotes-exosome-release
#16
Wei Chen, Yijun Guo, Wenjin Yang, Lei Chen, Dabin Ren, Chenxing Wu, Bin He, Ping Zheng, Wusong Tong
Traumatic brain injury (TBI) caused by the external force leads to the neuronal dysfunction and even death. TBI has been reported to significantly increase the phosphorylation of glial gap junction protein connexin 43 (Cx43), which in turn propagates damages into surrounding brain tissues. However, the neuroprotective and anti-apoptosis effects of glia-derived exosomes have also been implicated in recent studies. Therefore, we detected whether TBI-induced phosphorylation of Cx43 would promote exosome release in rat brain...
October 18, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29045505/surfaceome-profiling-enables-isolation-of-cancer-specific-exosomal-cargo-in-liquid-biopsies-from-pancreatic-cancer-patients
#17
J Castillo, V Bernard, F A San Lucas, K Allenson, M Capello, D U Kim, P Gascoyne, F C Mulu, B M Stephens, J Huang, H Wang, A A Momin, R O Jacamo, M Katz, R Wolff, M Javle, G Varadhachary, I I Wistuba, S Hanash, A Maitra, H Alvarez
Background: Detection of circulating tumor DNA (ctDNA) can be limited due to their relative scarcity in circulation, particularly while patients are actively undergoing therapy. Exosomes provide a vehicle through which cancer-specific material can be enriched from the compendium of circulating non-neoplastic tissue-derived nucleic acids. We performed a comprehensive profiling of the pancreatic ductal adenocarcinoma (PDAC) exosomal "surfaceome" in order to identify surface proteins that will render liquid biopsies amenable to cancer-derived exosome enrichment for downstream molecular profiling...
September 25, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045081/chasing-bubbles-for-cancer-diagnostics-cancer-researchers-are-pursuing-membrane-bound-microbubbles-and-exosomes-as-new-diagnostic-tools
#18
https://www.readbyqxmd.com/read/29044850/mesenchymal-stem-cells-therapy-a-promising-cell-based-therapy-for-treatment-of-myocardial-infraction
#19
REVIEW
Ayman El Sayed Shafei, Mahmoud Ahmed Ali, Hazem G Ghanem, Ahmed I Shehata, Ahmed A Abdelgawad, Hossam R Handal, Kareem A Talaat, Ahmed E Ashaal, Amal S El-Shal
AIM: For decades, mesenchymal stem (MSCs) cells had been used for cardiovascular diseases as regenerative therapy. This review is an attempt to summarize the types of MSCs involved in MI therapy, its possible mechanisms effects especially paracrine one in MI focusing on the studies (human and animal) conducted in the last 10 years. DISCUSSION: Recently, reports showed that MSC therapy could have infarct-limiting effects after myocardial infarction (MI) in both experimental and clinical trials...
October 16, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29043382/cell-transfer-of-information-via-mir-loaded-exosomes-a-biophysical-approach
#20
C Potrich, L Lunelli, V Vaghi, L Pasquardini, C Pederzolli
A new communication route among cells was reported in recent years, via extracellular vesicles and their cargo. Exosomes in particular are attracting increasing interest as privileged mediators of this cell communication route. The exosome-mediated transfer of nucleic acids, especially of microRNAs, is particularly promising for their use both as biomarkers of pathologies and as a therapeutic tool. Here, a simplified model of interaction among cells, microRNAs and vesicles is studied using a biophysical approach...
October 17, 2017: European Biophysics Journal: EBJ
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