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HLA-G, transplantation, regulatory cells, immune therapy, cellular therapy

S C Jordan, D Glotz
In transplantation, harnessing the immune system is essential for allograft survival and function. This session explores different aspects of the immune system during transplantation, including the effect of donor-specific anti-human leucocyte antigen (HLA) antibodies (DSAs), antibody-mediated rejection (AMR), B cell modulation and the role of immunoglobulin (Ig) therapy. It is well known that DSAs play a key role in the failure of allografts. Identifying and characterizing DSAs provides information that can aid in risk stratification of transplant recipients...
December 2014: Clinical and Experimental Immunology
Gaetano La Manna, Giulia Ghinatti, Pier Luigi Tazzari, Francesco Alviano, Francesca Ricci, Irene Capelli, Vania Cuna, Paola Todeschini, Eugenio Brunocilla, Pasqualepaolo Pagliaro, Laura Bonsi, Sergio Stefoni
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is emerging as a mediator of various biological and pathological states. However, the specific biological role of this molecule remains unclear, as it serves as a biomarker for many conditions. The high sensitivity of NGAL as a biomarker coupled with relatively low specificity may hide important biological roles. Data point toward an acute compensatory, protective role for NGAL in response to adverse cellular stresses, including inflammatory and oxidative stress...
2014: PloS One
Richard Banas, Carrie Miller, Lynda Guzik, Adriana Zeevi
Cells derived from the placenta have become the focus of extensive research concerning their ability to be used for regenerative medicine or cellular therapies. In a previous study, we characterized amnion-derived multipotent progenitor cells, or AMP cells, by in vitro methods and showed they were able to inhibit antigen-specific T-cell proliferation in a cell-to-cell contact-dependent fashion. Here we examine specific mechanisms involved in immunomodulation by AMP cells. We found that AMP cells significantly inhibited monocyte-derived myeloid dendritic cell (DC) maturation when placed in coculture...
2014: Cell Transplantation
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