C Dudreuilh, P Jarvis, N Beadle, I Pilecka, O Shaw, L Gardner, C Scottà , N Mamode, D S Game, A Sanchez-Fueyo, G Lombardi, A Learoyd, A Douiri, A Dorling
BACKGROUND: Kidney transplantation is the gold-standard treatment for patients with kidney failure. However, one-third of patients awaiting a kidney transplant are highly sensitized to human leukocyte antigens (HLA), resulting in an increased waiting time for a suitable kidney, more acute and chronic rejection, and a shorter graft survival compared to non-highly sensitised patients. Current standard immunosuppression protocols do not adequately suppress memory responses, and so alternative strategies are needed...
April 28, 2023: BMC Nephrology