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https://www.readbyqxmd.com/read/29774002/on-the-drive-specificity-of-freudian-drives-for-the-generation-of-seeking-activities-the-importance-of-the-underestimated-imperative-motor-factor
#1
Michael Kirsch, Wolfgang Mertens
Doubters of Freud's theory of drives frequently mentioned that his approach is outdated and therefore cannot be useful for solving current problems in patients with mental disorders. At present, many scientists believe that affects rather than drives are of utmost importance for the emotional life and the theoretical framework of affective neuroscience, developed by Panksepp, strongly underpinned this view. Panksepp evaluated seven so-called command systems and the SEEKING system is therein of central importance...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29773603/clinical-efficacy-of-ruxolitinib-and-chemotherapy-in-a-child-with-philadelphia-chromosome-like-acute-lymphoblastic-leukemia-with-golga5-jak2-fusion-and-induction-failure
#2
Yang Y Ding, Julie W Stern, Tracey F Jubelirer, Gerald B Wertheim, Fumin Li, Fengqi Chang, Zhaohui Gu, Charles G Mullighan, Yong Li, Richard C Harvey, I-Ming Chen, Cheryl L Willman, Stephen P Hunger, Marilyn M Li, Sarah K Tasian
No abstract text is available yet for this article.
May 17, 2018: Haematologica
https://www.readbyqxmd.com/read/29770565/a-review-of-child-stunting-determinants-in-indonesia
#3
REVIEW
Ty Beal, Alison Tumilowicz, Aang Sutrisna, Doddy Izwardy, Lynnette M Neufeld
Child stunting reduction is the first of 6 goals in the Global Nutrition Targets for 2025 and a key indicator in the second Sustainable Development Goal of Zero Hunger. The prevalence of child stunting in Indonesia has remained high over the past decade, and at the national level is approximately 37%. It is unclear whether current approaches to reduce child stunting align with the scientific evidence in Indonesia. We use the World Health Organization conceptual framework on child stunting to review the available literature and identify what has been studied and can be concluded about the determinants of child stunting in Indonesia and where data gaps remain...
May 17, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29767099/growth-performance-nutrient-digestibility-antioxidant-capacity-blood-biochemical-biomarkers-and-cytokines-expression-in-broiler-chickens-fed-different-phytogenic-levels
#4
Vasileios Paraskeuas, Konstantinos Fegeros, Irida Palamidi, Christine Hunger, Konstantinos C Mountzouris
The effects of inclusion levels of a phytogenic feed additive (PFA), characterized by menthol anethol and eugenol, on broiler growth performance, nutrient digestibility, biochemical biomarkers and total antioxidant capacity (TAC) of plasma and meat, as well as on the relative expression of selected cytokines, were studied in a 42-d experiment. A total of 225 one-day-old male Cobb broiler chickens were assigned into 3 treatments, with 5 replicates of 15 chickens each. Chickens were fed maize-soybean meal basal diets following a 3 phase (i...
June 2017: Animal nutrition
https://www.readbyqxmd.com/read/29758553/a-retrospective-cohort-study-on-patients-with-hidradenitis-suppurativa
#5
S Morteza Seyed Jafari, Evelyne Knüsel, Simone Cazzaniga, Robert E Hunger
BACKGROUND: Hidradenitis suppurativa (HS) is one of the most distressing conditions observed in dermatology and has a substantial negative effect on the quality of life of affected persons. OBJECTIVES: The aim of this study was to evaluate different treatment strategies in patients with HS. METHODS: In a retrospective cohort, all patients with HS (July 2015 to March 2017) were reviewed. Collected data consisted of patients' demographics, clinical characteristics, psychosocial situation, and previous and current treatments...
May 14, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29757091/striving-for-liminality-eating-disorders-and-social-suffering
#6
Karin Eli
In this article, I argue that eating disorders constitute a form of social suffering, in which sufferers embody liminality as a response to, and a reflection of, oppressive sociality, structural violence, and institutional constraints. Based on the illness narratives of people with anorexia nervosa, bulimia nervosa, and their subclinical variants in Israel, the analysis draws the experiential, the social, and the structural into critical focus. These narratives, which delineate lived experiences of self-starving, bingeing, and purging, and the attendant viscerality of hunger, fullness, and emptiness, reveal how participants developed an embodied drawing inward and away, being at once within and without society for extended periods of time, through eating disordered practices...
January 1, 2018: Transcultural Psychiatry
https://www.readbyqxmd.com/read/29751757/assessment-of-the-knowledge-and-attitude-of-infants-mothers-from-bushehr-iran-on-food-security-using-anthropometric-indicators-in-2016-a-cross-sectional-study
#7
Sedigheh Yeganeh, Niloofar Motamed, Saeid NajafpourBoushehri, Maryam Ravanipour
BACKGROUND: Among the main elements of food security, in terms of food usage, are knowledge and attitude. These are particularly important during the initial two years of a child's life. The present study was conducted in 2016 and aimed to assess the knowledge and attitude of infants' mothers from Bushehr (Iran) towards food security using anthropometric indicators. METHODS: The present cross-sectional, descriptive-analytical study was performed on 400 mothers of children aged 1-2 years in Bushehr, Iran...
May 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29751193/adolescents-perceive-a-low-added-sugar-adequate-fiber-diet-to-be-more-satiating-and-equally-palatable-compared-to-a-high-added-sugar-low-fiber-diet-in-a-randomized-crossover-design-controlled-feeding-pilot-trial
#8
Tanya M Halliday, Sarah V Liu, Lori B Moore, Valisa E Hedrick, Brenda M Davy
BACKGROUND: High added sugar (AS) intake is associated with obesity and poor diet quality. Guidelines recommended limiting AS to 5-10% of total energy intake, but palatability and feasibility of this AS intake level is uncertain. OBJECTIVE: To compare adolescents' perceptions of hunger, fullness, and palatability in response to a low AS adequate fiber (LASAF; 5% total energy from AS and 13.5 g fiber/1000 kcal) and a high AS low fiber (HASLF; 25% total energy form AS and 8...
May 5, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29748653/potential-effects-of-fat-mass-and-fat-free-mass-on-energy-intake-in-different-states-of-energy-balance
#9
REVIEW
R James Stubbs, M Hopkins, G S Finlayson, C Duarte, C Gibbons, J E Blundell
Recently models have attempted to integrate the functional relationships of fat mass (FM) and fat-free mass (FFM) with the control of human energy intake (EI). Cross-sectional evidence suggests that at or close to EB, FFM is positively related to hunger and EI, whereas FM either shows a weak negative or no association with ad libitum EI. Further analysis suggests that the effects of FFM and FM on EI may be mediated by resting metabolic rate (RMR). These studies suggest that energy turnover is associated with EI and the largest determinant of energy requirements in most humans is FFM...
May 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29746793/high-throughput-flow-cytometry-identifies-small-molecule-inhibitors-for-drug-repurposing-in-t-all
#10
Dominique R Perez, Christian K Nickl, Anna Waller, Cristina Delgado-Martin, Travis Woods, Nitesh D Sharma, Michelle L Hermiston, Mignon L Loh, Stephen P Hunger, Stuart S Winter, Alexandre Chigaev, Bruce Edwards, Larry A Sklar, Ksenia Matlawska-Wasowska
Kinase inhibitors have dramatically increased patient survival in a multitude of cancers, including hematological malignancies. However, kinase inhibitors have not yet been integrated into current clinical trials for patients with T-cell-lineage acute lymphoblastic leukemia (T-ALL). In this study, we used a high-throughput flow cytometry (HTFC) approach to test a collection of small-molecule inhibitors, including 26 FDA-approved tyrosine kinase inhibitors in a panel of T-ALL cell lines and patient-derived xenografts...
May 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29740277/hedonic-eating-and-the-delicious-circle-from-lipid-derived-mediators-to-brain-dopamine-and-back
#11
REVIEW
Roberto Coccurello, Mauro Maccarrone
Palatable food can be seductive and hedonic eating can become irresistible beyond hunger and negative consequences. This is witnessed by the subtle equilibrium between eating to provide energy intake for homeostatic functions, and reward-induced overeating. In recent years, considerable efforts have been devoted to study neural circuits, and to identify potential factors responsible for the derangement of homeostatic eating toward hedonic eating and addiction-like feeding behavior. Here, we examined recent literature on "old" and "new" players accountable for reward-induced overeating and possible liability to eating addiction...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29738973/functional-group-and-stereochemical-requirements-for-substrate-binding-by-ghrelin-o-acyltransferase-revealed-by-unnatural-amino-acid-incorporation
#12
Elizabeth R Cleverdon, Tasha R Davis, James L Hougland
Ghrelin is a small peptide hormone that undergoes a unique posttranslational modification, serine octanoylation, to play its physiological roles in processes including hunger signaling and glucose metabolism. Ghrelin O-acyltransferase (GOAT) catalyzes this posttranslational modification, which is essential for ghrelin to bind and activate its cognate GHS-R1a receptor. Inhibition of GOAT offers a potential avenue for modulating ghrelin signaling for therapeutic effect. Defining the molecular characteristics of ghrelin that lead to binding and recognition by GOAT will facilitate the development and optimization of GOAT inhibitors...
April 21, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29733864/explaining-the-relationship-between-attachment-anxiety-eating-behaviour-and-bmi
#13
Laura L Wilkinson, Angela C Rowe, Eric Robinson, Charlotte A Hardman
Previous research indicates that attachment anxiety (fear of abandonment) is predictive of overeating and higher body mass index (BMI). The current study explored the nature of the mechanisms underpinning this relationship. Study 1 assessed the relative contribution of 'emotional eating', 'susceptibility to hunger' and 'uncontrolled eating'. Study 2 assessed whether misperception of emotion and poor emotion management would mediate the relationship between attachment anxiety and stress-induced eating (and then BMI)...
May 4, 2018: Appetite
https://www.readbyqxmd.com/read/29731733/of-meat-and-men-sex-differences-in-implicit-and-explicit-attitudes-toward-meat
#14
Hamish J Love, Danielle Sulikowski
Modern attitudes to meat in both men and women reflect a strong meat-masculinity association. Sex differences in the relationship between meat and masculinity have not been previously explored. In the current study we used two IATs (implicit association tasks), a visual search task, and a questionnaire to measure implicit and explicit attitudes toward meat in men and women. Men exhibited stronger implicit associations between meat and healthiness than did women, but both sexes associated meat more strongly with 'healthy' than 'unhealthy' concepts...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29731001/effect-of-timing-of-corn-silage-supplementation-to-holstein-dairy-cows-given-limited-daily-access-to-pasture-intake-and-performance
#15
D A Mattiauda, M J Gibb, M Carriquiry, S Tamminga, P Chilibroste
The timing in which supplements are provided in grazing systems can affect dry matter (DM) intake and productive performance. The objective of this study was to evaluate the effect of timing of corn silage supplementation on ingestive behaviour, DM intake, milk yield and composition in grazing dairy cows. In total, 33 Holstein dairy cows in a randomized block design grazed on a second-year mixed grass-legume pasture from 0900 to 1500 h and received 2.7 kg of a commercial supplement at each milking. Paddock sizes were adjusted to provide a daily herbage allowance of 15 kg DM/cow determined at ground level...
May 7, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29730186/just-add-water-effects-of-added-gastric-distention-by-water-on-gastric-emptying-and-satiety-related-brain-activity
#16
Guido Camps, Ralf Veit, Monica Mars, Cees de Graaf, Paul Am Smeets
BACKGROUND: Gastric distention contributes to meal termination. There is little research on the neural correlates of gastric distention by food. To date, neural measures have not been obtained concurrently with measurements of gastric distention. OBJECTIVES: 1) To study how offering a small versus a large water load following a standardized nutrient load affects gastric distention over time. 2) To assess associations between satiety experiences and brain activity and the degree of gastric distention...
May 3, 2018: Appetite
https://www.readbyqxmd.com/read/29723574/influences-of-hunger-satiety-and-oral-glucose-on-functional-brain-connectivity-a-multimethod-resting-state-fmri-study
#17
Arkan Al-Zubaidi, Marcus Heldmann, Alfred Mertins, Kamila Jauch-Chara, Thomas F Münte
A major regulatory task of the organism is to keep brain functions relatively constant in spite of metabolic changes (e.g., hunger vs. satiety) or availability of energy (e.g., glucose administration). Resting-state functional magnetic resonance imaging (rs-fMRI) can reveal resulting changes in brain function but previous studies have focused mostly on the hypothalamus. Therefore, we took a whole brain approach and examined 24 healthy normal-weight men once after 36 hours of fasting and once in a satiated state (six meals over the course of 36 hours)...
April 30, 2018: Neuroscience
https://www.readbyqxmd.com/read/29722834/effects-of-caloric-and-noncaloric-sweeteners-on-antroduodenal-motility-gastrointestinal-hormone-secretion-and-appetite-related-sensations-in-healthy-subjects
#18
Anne Christin Meyer-Gerspach, Jessica R Biesiekierski, Eveline Deloose, Egbert Clevers, Alessandra Rotondo, Jens F Rehfeld, Inge Depoortere, Lukas Van Oudenhove, Jan Tack
Background: Activation of gastrointestinal (GI) sweet taste receptors by caloric sweeteners triggers secretion of anorexigenic and inhibition of orexigenic GI hormones to regulate food intake. The effect of noncaloric sweeteners on these mechanisms is controversial. We have recently shown that motilin-induced gastric phase III contractions signal hunger feelings, thereby identifying GI motility, and its regulatory hormone motilin, as novel players in food intake regulation. Objective: The objective of the present study was to determine the effect of caloric and noncaloric sweeteners on GI motility, GI hormone secretion, and hunger in humans...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29717180/zinc-use-efficiency-is-enhanced-in-wheat-through-nanofertilization
#19
Ashwin Dapkekar, Paresh Deshpande, Manoj D Oak, Kishore M Paknikar, Jyutika M Rajwade
Ferti-fortification of wheat with zinc, an essential micronutrient is one of the strategies for combating 'hidden hunger' in a large proportion of people all over the world. During fertilization, application of large quantities of micronutrients often results in nutrient wastage and subsequent environmental pollution. Here, we report zinc complexed chitosan nanoparticles (Zn-CNP) for ferti-fortification of durum wheat in field-scale experiments. The efficacy of Zn-CNP was assessed vis-à-vis conventionally applied ZnSO4 (0...
May 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29715502/a-multimodal-investigation-of-impulsivity-as-a-moderator-of-the-relation-between-momentary-elevations-in-negative-internal-states-and-subsequent-dietary-lapses
#20
Stephanie M Manasse, Rebecca J Crochiere, Diane H Dallal, Edward W Lieber, Leah M Schumacher, Ross D Crosby, Meghan L Butryn, Evan M Forman
Suboptimal outcomes from behavioral weight loss (BWL) treatments are partially attributable to accumulated instances of non-adherence to dietary prescriptions (i.e., dietary lapses). Results identifying negative internal triggers for dietary lapses are inconsistent, potentially due to individual differences that impact how individuals respond to cues. Impulsivity is one factor that likely influences reactivity to internal states. We examined three dimensions of impulsivity (delay discounting, inhibitory control, and negative urgency) as moderators of the relation between affective and physical states and subsequent dietary lapses at the beginning of BWL...
April 28, 2018: Appetite
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