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Emil Anthony T Say, Wasim A Samara, Chloe T L Khoo, George N Magrath, Priya Sharma, Sandor Ferenczy, Carol L Shields
PURPOSE: To study the parafoveal capillary density using optical coherence tomography angiography (OCTA) in eyes treated with plaque radiotherapy. RESEARCH DESIGN: Retrospective comparative case series. PARTICIPANTS: Ten patients treated with plaque radiotherapy for choroidal melanoma without evident radiation maculopathy on ophthalmoscopy or optical coherence tomography were imaged with OCTA. MAIN OUTCOME MEASURE: Comparison of the parafoveal capillary density in the superficial and deep capillary plexuses in the irradiated versus fellow nonirradiated eye...
September 2016: Retina
Katherine A Harrisson, Alexandra Pavlova, Anders Gonçalves da Silva, Rebecca Rose, James K Bull, Melanie L Lancaster, Neil Murray, Bruce Quin, Peter Menkhorst, Michael J L Magrath, Paul Sunnucks
Genetic diversity is positively linked to the viability and evolutionary potential of species but is often compromised in threatened taxa. Genetic rescue by gene flow from a more diverse or differentiated source population of the same species can be an effective strategy for alleviating inbreeding depression and boosting evolutionary potential. The helmeted honeyeater Lichenostomus melanops cassidix is a critically endangered subspecies of the common yellow-tufted honeyeater. Cassidix has declined to a single wild population of ~130 birds, despite being subject to intensive population management over recent decades...
March 2016: Molecular Ecology
Carol L Shields, Rodrigo Jorge, Emil Anthony T Say, George Magrath, Adel Alset, Emi Caywood, Ann M Leahey, Pascal Jabbour, Jerry A Shields
PURPOSE: The objective of this study was to compare outcomes after intravenous chemotherapy (IVC) versus intra-arterial chemotherapy (IAC) for unilateral retinoblastoma. DESIGN: A retrospective comparative interventional case series. METHODS: Patients with unilateral retinoblastoma managed with either IVC using vincristine, etoposide, and carboplatin or IAC using melphalan with or without topotecan with a minimum of 1-year follow-up were compared...
March 2016: Asia-Pacific Journal of Ophthalmology
Christopher B Sturdy, Darren S Proppe
Although it is known that animals attend to the vocalizations of others (referred to as eavesdropping), what has been missing, or at least left experimentally unproven, until now is whether animals can learn new associations between a signal and a threat. Here Magrath and colleagues (Current Biology, 25(15), 2047-2050, 2015) have for the first time conducted a field experiment that demonstrates just this: superb fairy-wrens learned to associate a novel vocalization with a predator.
September 2016: Learning & Behavior
Martín J Mazzoglio y Nabar, Milagros María Muñiz, Alexis A Mejías Delamano, Santiago Muñoz, Nahuel Magrath Guimet
We report a series of 9 male HIV + patients, average age of 41.2 years, viral load negative (<50 copies RNA/ml), treated with antiretroviral (nucleoside and non-nucleoside inhibitors of reverse transcriptase) without systemic infections, the CNS diseases or marker or corticoidoterapia in progress. Were evaluated and supported by their infectologists interconsultation during the period October 2008-October 2013 by depressive syndrome. Psychotherapeutic and psychiatric treatment was initiated with SSRIs and clonazepam; Neuroimaging control and biochemical laboratory studies at baseline and 2 months of treatment were conducted...
May 2015: Vertex: Revista Argentina de Psiquiatriá
Eduardo Cazap, Ian Magrath, T Peter Kingham, Ahmed Elzawawy
Noncommunicable diseases are now recognized by the United Nations and WHO as a major public health crisis. Cancer is a main part of this problem, and health care systems are facing a great challenge to improve cancer care, control costs, and increase systems efficiency. The disparity in access to care and outcomes between high-income countries and low- and middle-income countries is staggering. The reasons for this disparity include cost, access to care, manpower and training deficits, and a lack of awareness in the lay and medical communities...
January 1, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Wasim A Samara, Emil A T Say, Chloe T L Khoo, Timothy P Higgins, George Magrath, Sandor Ferenczy, Carol L Shields
PURPOSE: To analyze the foveal avascular zone (FAZ) in normal eyes using optical coherence tomography angiography. METHODS: Prospective noncomparative case series. The parafoveal region of 70 eyes from 67 healthy subjects was imaged using optical coherence tomography angiography to visualize the superficial and deep capillary plexuses and correlated with standard macular volume scans using spectral domain optical coherence tomography to determine foveal morphology...
November 2015: Retina
Monica Sethi, Melissa Magrath, Eduardo Somoza, Manish Parikh, John Saunders, Aku Ude-Welcome, Bradley Schwack, Marina Kurian, George Fielding, Christine Ren-Fielding
BACKGROUND: Leak after laparoscopic sleeve gastrectomy (LSG) often presents after hospital discharge, making timely diagnosis difficult. This study evaluates the utility of radiological upper gastrointestinal (UGI) series and clinical indicators in detecting leak after LSG. METHODS: A retrospective case-controlled study of 1762 patients who underwent LSG from 2006 to 2014 was performed. All patients with radiographically confirmed leaks were included. Controls consisted of patients who underwent LSG without leak, selected using a 10:1 case-match...
June 2016: Surgical Endoscopy
Monica Sethi, Melissa Beitner, Melissa Magrath, Bradley Schwack, Marina Kurian, George Fielding, Christine Ren-Fielding
INTRODUCTION: Weight loss after laparoscopic adjustable gastric banding (LAGB) can be influenced by a variety of factors. The objective of this study is to investigate whether the maximum amount of previous weight loss with diet and exercise, prior to evaluation for bariatric surgery, is predictive of postoperative weight loss success among primary LAGB patients. METHODS: A retrospective cohort study was designed from a prospectively collected database at a single institution...
May 2016: Surgical Endoscopy
Robert D Magrath, Tonya M Haff, Jessica R McLachlan, Branislav Igic
Many vertebrates gain critical information about danger by eavesdropping on other species' alarm calls [1], providing an excellent context in which to study information flow among species in animal communities [2-4]. A fundamental but unresolved question is how individuals recognize other species' alarm calls. Although individuals respond to heterospecific calls that are acoustically similar to their own, alarms vary greatly among species, and eavesdropping probably also requires learning [1]. Surprisingly, however, we lack studies demonstrating such learning...
August 3, 2015: Current Biology: CB
Chloe T L Khoo, George Magrath, Carol L Shields
A 17-year-old asymptomatic boy with a referral diagnosis of "macular gliosis" was found to have a combined hamartoma of the retina and retinal pigment epithelium. Enhanced depth imaging optical coherence tomography showed characteristic features of mini- and maxi-peaks from vitreoretinal traction.
2015: Journal of Pediatric Ophthalmology and Strabismus
Gregory R Hartlage, Jonathan D Suever, Stephanie Clement-Guinaudeau, Patrick T Strickland, Nima Ghasemzadeh, R Patrick Magrath, Ankit Parikh, Stamatios Lerakis, Michael H Hoskins, Angel R Leon, Michael S Lloyd, John N Oshinski
BACKGROUND: Despite marked benefits in many heart failure patients, a considerable proportion of patients treated with cardiac resynchronization therapy (CRT) fail to respond appropriately. Recently, a "U-shaped" (type II) wall motion pattern identified by cardiovascular magnetic resonance (CMR) has been associated with improved CRT response compared to a homogenous (type I) wall motion pattern. There is also evidence that a left ventricular (LV) lead localized to the latest contracting LV site predicts superior response, compared to an LV lead localized remotely from the latest contracting LV site...
2015: Journal of Cardiovascular Magnetic Resonance
Monica Sethi, Jonathan Zagzag, Karan Patel, Melissa Magrath, Eduardo Somoza, Manish S Parikh, John K Saunders, Aku Ude-Welcome, Bradley F Schwack, Marina S Kurian, George A Fielding, Christine J Ren-Fielding
BACKGROUND: Staple line leak is a serious complication of sleeve gastrectomy. Intraoperative methylene blue and air leak tests are routinely used to evaluate for leak; however, the utility of these tests is controversial. We hypothesize that the practice of routine intraoperative leak testing is unnecessary during sleeve gastrectomy. METHODS: A retrospective cohort study was designed using a prospectively collected database of seven bariatric surgeons from two institutions...
March 2016: Surgical Endoscopy
Branislav Igic, Jessica McLachlan, Inkeri Lehtinen, Robert D Magrath
Animals often mimic dangerous or toxic species to deter predators; however, mimicry of such species may not always be possible and mimicry of benign species seems unlikely to confer anti-predator benefits. We reveal a system in which a bird mimics the alarm calls of harmless species to fool a predator 40 times its size and protect its offspring against attack. Our experiments revealed that brown thornbills (Acanthiza pusilla) mimic a chorus of other species' aerial alarm calls, a cue of an Accipiter hawk in flight, when predators attack their nest...
June 22, 2015: Proceedings. Biological Sciences
Sally L Sherwen, Paul H Hemsworth, Kym L Butler, Kerry V Fanson, Michael J L Magrath
Free range exhibits are becoming increasingly popular in zoos as a means to enhance interaction between visitors and animals. However very little research exists on the impacts of visitors on animal behaviour and stress in free range exhibits. We investigated the effects of visitor number on the behaviour and stress physiology of Kangaroo Island (KI) Kangaroos, Macropus fuliginosus fuliginosus, and Red Kangaroos, Macropus rufus, housed in two free range exhibits in Australian zoos. Behavioural observations were conducted on individual kangaroos at each site using instantaneous scan sampling to record activity (e...
July 2015: Zoo Biology
Wasim A Samara, Chloe T L Khoo, George Magrath, Carol L Shields
A 6-month-old female infant was referred following three episodes of spontaneous hyphema. Iris juvenile xanthogranuloma was suspected but not clinically visible. Multimodal imaging with fluorescein angiography, anterior segment optical coherence tomography, and ultrasound biomicroscopy were used to detect the flat, transparent lesion and cytopathology confirmed juvenile xanthogranuloma.
2015: Journal of Pediatric Ophthalmology and Strabismus
Karen Magrath
No abstract text is available yet for this article.
March 2015: Nursing New Zealand, Kai Tiaki
S Dehkharghani, H Mao, L Howell, X Zhang, K S Pate, P R Magrath, F Tong, L Wei, D Qiu, C Fleischer, J N Oshinski
BACKGROUND AND PURPOSE: Applications for noninvasive biologic temperature monitoring are widespread in biomedicine and of particular interest in the context of brain temperature regulation, where traditionally costly and invasive monitoring schemes limit their applicability in many settings. Brain thermal regulation, therefore, remains controversial, motivating the development of noninvasive approaches such as temperature-sensitive nuclear MR phenomena. The purpose of this work was to compare the utility of competing approaches to MR thermometry by using proton resonance frequency chemical shift...
June 2015: AJNR. American Journal of Neuroradiology
Jeremy Collins, Cort Sommerville, Patrick Magrath, Bruce Spottiswoode, Benjamin H Freed, Keith H Benzuly, Robert Gordon, Himabindu Vidula, Dan C Lee, Clyde Yancy, James Carr, Michael Markl
BACKGROUND: Nonischemic cardiomyopathy is a common cause of left ventricular (LV) dysfunction and myocardial fibrosis. The purpose of this study was to noninvasively evaluate changes in segmental LV extracellular volume (ECV) fraction, LV velocities, myocardial scar, and wall motion in nonischemic cardiomyopathy patients. METHODS AND RESULTS: Cardiac MRI including pre- and postcontrast myocardial T1 mapping and velocity quantification (tissue phase mapping) of the LV (basal, midventricular, and apical short axis) was applied in 31 patients with nonischemic cardiomyopathy (50±18 years)...
January 2015: Circulation. Cardiovascular Imaging
C Norman Coleman, Silvia C Formenti, Tim R Williams, Daniel G Petereit, Khee C Soo, John Wong, Nelson Chao, Lawrence N Shulman, Surbhi Grover, Ian Magrath, Stephen Hahn, Fei-Fei Liu, Theodore DeWeese, Samir N Khleif, Michael Steinberg, Lawrence Roth, David A Pistenmaa, Richard R Love, Majid Mohiuddin, Bhadrasain Vikram
The growing burden of non-communicable diseases including cancer in low- and lower-middle income countries (LMICs) and in geographic-access limited settings within resource-rich countries requires effective and sustainable solutions. The International Cancer Expert Corps (ICEC) is pioneering a novel global mentorship-partnership model to address workforce capability and capacity within cancer disparities regions built on the requirement for local investment in personnel and infrastructure. Radiation oncology will be a key component given its efficacy for cure even for the advanced stages of disease often encountered and for palliation...
2014: Frontiers in Oncology
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