keyword
https://read.qxmd.com/read/37881891/hydroxychloroquine-chloroquine-qt-prolongation-and-major-adverse-cardiac-events-a-meta-analysis-and-scoping-review
#21
REVIEW
Michael Cristian Garcia, Kai La Tsang, Simran Lohit, Jiawen Deng, Tyler Schneider, Jessyca Matos Silva, Lawrence Mbuagbaw, Anne Holbrook
OBJECTIVES: We aimed to evaluate the high-quality literature on the frequency and nature of major adverse cardiac events (MACE) associated with either hydroxychloroquine (HCQ) or chloroquine (CQ). DATA SOURCES: We searched Medline, Embase, International Pharmaceutical Abstracts, and Cochrane Central from 1996 onward using search strategies created in collaboration with medical science librarians. STUDY SELECTION AND DATA EXTRACTION: Randomized controlled trials (RCTs) published in English language from January 1996 to September 2022, involving adult patients at least 18 years of age, were selected...
October 26, 2023: Annals of Pharmacotherapy
https://read.qxmd.com/read/37855654/-when-the-brain-dictates-the-rhythm
#22
JOURNAL ARTICLE
Andrea Burri, Nina Graf, Michael Studhalter
In rare cases, an HSV-Encephalitis can lead to sinus node dysfunction, as was the case in this 70-year old woman who suffered from recurrent syncopes. Diagnostic work-up showed sinus bradycardias and short-lasting sinus arrests, primarily consider-ed to be of cardiac etiology. After development of fever and neurological alteration, an HSV1 encephalitis was diagnosed. As our research of the current literature showed, the connection between the two is not completely clear. The HSVtypical infestation of the insular cortex, which influences the autonomic nervous system, should be discussed by all means...
August 2023: Praxis
https://read.qxmd.com/read/37844436/effects-of-attachment-styles-childhood-traumas-and-alexithymia-in-turkish-patients-with-epilepsy-and-functional-seizures
#23
JOURNAL ARTICLE
Ahmet Onur Keskin, Ebru Altintas, Vahide Deniz Yerdelen, Bireylül Demir, Meric Yavuz Colak
INTRODUCTION: In this cross-sectional study, we used self-report scales to compare childhood traumas, attachment styles, and alexithymia among patients with functional seizures (FS) to patients with epilepsy and healthy controls. We also investigated risk factors associated with FS. MATERIAL AND METHODS: A total of 44 patients with epilepsy, 14 patients with FS, and 25 healthy controls were included. All participants were over the age of 18 and were referred to the Baskent University Adana Epilepsy and Video-EEG Center...
October 14, 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/37827588/the-2023-canadian-cardiovascular-society-clinical-practice-update-on-management-of-the-patient-with-a-prolonged-qt-interval
#24
Ross A Davies, Virginie Beauséjour Ladouceur, Martin S Green, Jacqueline Joza, David N Juurlink, Andrew D Krahn, M Sean McMurtry, Jason D Roberts, Thomas M Roston, Shubhayan Sanatani, Christian Steinberg, Ciorsti MacIntyre
A prolonged QT interval on the electrocardiogram is associated with an increased risk of the torsades de pointes form of ventricular arrhythmia resulting in syncope, sudden cardiac arrest or death, or misdiagnosis as a seizure disorder. The cause of QT prolongation can be congenital and inherited as an autosomal dominant variant, or it can be transient and acquired, often because of QT-prolonging drugs or electrolyte abnormalities. Automated measurement of the QT interval can be inaccurate, especially when the baseline electrocardiogram is abnormal, and manual verification is recommended...
October 2023: Canadian Journal of Cardiology
https://read.qxmd.com/read/37821955/the-role-of-creatine-kinase-in-distinguishing-generalized-tonic-clonic-seizures-from-psychogenic-non-epileptic-seizures-pnes-and-syncope-a-retrospective-study-and-meta-analysis-of-1300-patients
#25
REVIEW
Ramy Abdelnaby, Anas Elgenidy, Jan Heckelmann, Mahmoud Mostafa Bedewy, Ahmed Samy Shabib, Mohamed Ayman Ebrahim, Khaled Abdelmoneim Elmenawi, Imene Maallem, Merna Wagih Youssef, Abdelrahman M Attia, Mostafa Hossam Moawad, Khaled Ashraf Mohamed, Ahmed Gaballa
BACKGROUND/AIM: As the clinical differentiation between epileptic seizures, psychogenic non-epileptic seizures (PNES), and syncope depends mainly on a detailed report of the event, which may not be available, an objective assessment of a potential biochemical analysis is needed. We aimed to investigate whether serum creatine kinase (CK) could be used to differentiate epileptic seizure from PNES and syncope and to assess the strength of evidence present. METHODS: We directed a retrospective cohort study coupled with a systematic review and meta-analysis of studies that measured CK in patients with epilepsy, PNES, syncope, and healthy controls...
October 12, 2023: Neurological research and practice
https://read.qxmd.com/read/37797258/watch-that-bite-syncope-versus-seizure
#26
Tony Zhang
No abstract text is available yet for this article.
October 6, 2023: New Zealand Medical Journal
https://read.qxmd.com/read/37762746/the-heart-and-seizures-friends-or-enemies
#27
REVIEW
Elena Pasini, Roberto Michelucci
The heart and seizures are closely linked by an indissoluble relationship that finds its basis in the cerebral limbic circuit whose mechanisms remain largely obscure. The differential diagnosis between seizures and syncopes has always been a cornerstone of the collaboration between cardiologists and neurologists and is renewed as a field of great interest for multidisciplinary collaboration in the era of the diffusion of prolonged telemonitoring units. The occurrence of ictal or post-ictal arrhythmias is currently a cause of great scientific debate with respect to the role and risks that these complications can generate (including sudden unexpected death in epilepsy)...
September 6, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37756017/diagnostic-value-of-intermittent-photic-stimulation-among-adult-patients-in-a-tertiary-referral-epilepsy-center-a-retrospective-study
#28
JOURNAL ARTICLE
Bernhard J Steinhoff, Tassanai Intravooth, Jitender Gupta, Viviane Bernedo-Paredes, Patricia Mahn, Jakob Stockinger, Peter Martin, Anke M Staack
PURPOSE: Photosensitivity is a phenomenon that may be elicited by standardized intermittent photic stimulation during EEG recording and is detected more frequently in children and adolescents. Nevertheless, at our Epilepsy Center, we routinely assess photosensitivity in all newly referred adult patients. In this investigation, we sought to address the diagnostic yield under the prerequisites described. METHODS: We reanalyzed all routine EEG recordings among referrals to the department of adults during the first six months of 2019, including a simultaneous video that is always coregistered in our center...
September 25, 2023: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://read.qxmd.com/read/37728293/left-cardiac-sympathetic-denervation-in-children-with-jervell-lange-nielsen-syndrome-and-drug-refractory-torsades-a-case-series
#29
JOURNAL ARTICLE
Deepanjan Bhattacharya, Narayanan Namboodiri, Madhusoodanan Pillai Sreelekshmi, Mukund A Prabhu, Abhilash Sreevilasam Pushpangadhan, Sabarinath Menon, Baiju S Dharan, Ajitkumar Valaparambil
INTRODUCTION: Long QT syndrome is an inherited malignant channelopathy which leads to life-threatening arrhythmia, with multiple genotypes. Jervell and Lange-Nielsen syndrome (JLNS) is an autosomal recessive subtype of this disease, characterized by congenital sensorineural deafness and a high incidence of sudden cardiac death (SCD). METHODOLOGY: We prospectively followed up six children who underwent left cardiac sympathetic denervation (LCSD) for JLNS in view of high-risk features despite being on maximally tolerated doses of oral propranolol...
September 20, 2023: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/37714573/cessations-of-consciousness-in-meditation-advancing-a-scientific-understanding-of-nirodha-sam%C3%A4-patti
#30
JOURNAL ARTICLE
Ruben E Laukkonen, Matthew D Sacchet, Henk Barendregt, Kathryn J Devaney, Avijit Chowdhury, Heleen A Slagter
Absence of consciousness can occur due to a concussion, anesthetization, intoxication, epileptic seizure, or other fainting/syncope episode caused by lack of blood flow to the brain. However, some meditation practitioners also report that it is possible to undergo a total absence of consciousness during meditation, lasting up to 7 days, and that these "cessations" can be consistently induced. One form of extended cessation (i.e., nirodha samāpatti) is thought to be different from sleep because practitioners are said to be completely impervious to external stimulation...
2023: Progress in Brain Research
https://read.qxmd.com/read/37711931/insulinoma-in-patient-with-nonalcoholic-steatohepatitis
#31
Daniel Cain, Ricardo Anguiano-Albarran, Franklin Obi, Sidart Pradeep, Steven Mudrovich, Melvin Simien
An insulinoma is a rare neuroendocrine tumor characterized by inappropriate secretion of insulin with resultant hypoglycemia and concomitant symptoms. Symptoms include diaphoresis, tremor, palpitations, tachycardia, visual disturbances, weakness, confusion, syncope, seizures, and even coma. Enteropancreatic neoplasms are rare in general but among them, insulinomas are among the more common neuroendocrine tumors though they still have a very low incidence. They can be benign or malignant, however, the latter is exceptionally rare...
August 2023: Curēus
https://read.qxmd.com/read/37626532/sub-scalp-implantable-telemetric-eeg-site-for-the-management-of-neurological-and-behavioral-disorders-beyond-epilepsy
#32
REVIEW
Steven V Pacia
Sub-scalp Implantable Telemetric EEG (SITE) devices are under development for the treatment of epilepsy. However, beyond epilepsy, continuous EEG analysis could revolutionize the management of patients suffering from all types of brain disorders. This article reviews decades of foundational EEG research, collected from short-term routine EEG studies of common neurological and behavioral disorders, that may guide future SITE management and research. Established quantitative EEG methods, like spectral EEG power density calculation combined with state-of-the-art machine learning techniques applied to SITE data, can identify new EEG biomarkers of neurological disease...
August 8, 2023: Brain Sciences
https://read.qxmd.com/read/37602025/the-heart-remembers-a-case-of-cardiac-memory
#33
Riddhima Naik, Harshith Thyagaturu, Maan Awad, Edward Bischof
An 80-year-old male with a history of atrial fibrillation and a single-chamber ventricular pacemaker presented to the hospital for an elective colonoscopy. He experienced a transient episode of unresponsiveness with seizure-like activity before the procedure. This prompted him to get an EKG showing deep T-wave inversions (TWIs) in the precordial leads on a background of paced beats. Such findings were concerning for an acute and potentially life-threatening process such as myocardial infarction (MI) or intracranial insult...
July 2023: Curēus
https://read.qxmd.com/read/37546063/beyond-syncopal-episodes-a-complicated-hyperkalemic-emergency-manifesting-as-complete-heart-block-and-seizure-versus-convulsive-syncope-cascade
#34
Mukosolu F Obi, Hyun Joon Cho, Manjari Sharma, Chelsea Noel, Paul R Gargiulo, Melissa M Vega, Win Hlaing
We present a case involving an 87-year-old woman who had a hyperkalemic emergency. This condition was further complicated by complete heart block (CHB) and seizure-like activity. This case emphasizes the challenge of differentiating between seizures and convulsive syncope. Achieving an accurate diagnosis is essential for determining the appropriate medical treatment. This case report highlights the various symptoms and complications associated with hyperkalemia, emphasizing the importance of conducting a thorough examination to explore other potential causes...
July 2023: Curēus
https://read.qxmd.com/read/37519698/ventricular-standstill-disguised-as-epilepsy-a-case-report-on-stokes-adams-attacks
#35
Mykha Marie B Tabuzo, Maxine Lourraine T Ty, Roland Dominic G Jamora
BACKGROUND: Stokes-Adams attacks presenting as convulsions may be difficult to distinguish from epilepsy. Stokes-Adams Syndrome is a transient abrupt collapse into unconsciousness due to a sudden but pronounced decrease in cardiac output caused by change in heart rate and rhythm, resulting in syncope. CASE PRESENTATION: We report a patient who presented with multiple convulsive episodes managed as epilepsy, until she was found to have paroxysmal total atrioventricular block...
July 2023: Heliyon
https://read.qxmd.com/read/37506565/hypophosphatemia-as-a-possible-biomarker-for-epileptic-seizures-at-the-emergency-department
#36
JOURNAL ARTICLE
Maria P Coutinho, Patrícia Faustino, Filipa Ladeira, Lia Leitão
INTRODUCTION: Hypophosphatemia seems to be temporally associated with seizures, despite not being considered a trigger. We aimed to evaluate hypophosphatemia as a biomarker for seizures. METHODS: Retrospective study, including all consecutive patients admitted at our central hospital's emergency department from 01/01-31/03/2021, screened as "altered consciousness/syncope" or "seizures", with available phosphate levels. RESULTS: 277 patients included, mostly male (61...
July 17, 2023: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/37501072/characterization-of-non-cardiac-arrest-pulsepoint-activations-in-public-and-private-settings
#37
JOURNAL ARTICLE
Jennifer Blackwood, Mohamud R Daya, Ben Sorenson, Brian Schaeffer, Mike Dawson, Michael Charter, James Mark Nania, Julie Charbonneau, Jeremy Robertson, Michael Mancera, Chris Carbon, Dawn B Jorgenson, Mengqi Gao, Richard Price, Chris Rosse, Thomas Rea
BACKGROUND: Geospatial smartphone application alert systems are used in some communities to crowdsource community response for out-of-hospital cardiac arrest (OHCA). Although the clinical focus of this strategy is OHCA, dispatch identification of OHCA is imperfect so that activation may occur for the non-arrest patient. The frequency and clinical profile of such non-arrest patients has not been well-investigated. METHODS: We undertook a prospective 3-year cohort investigation of patients for whom a smartphone geospatial application was activated for suspected OHCA in four United States communities (total population ~1 million)...
July 27, 2023: BMC Emergency Medicine
https://read.qxmd.com/read/37479398/woman-with-syncopal-episode-and-seizure-like-activity
#38
JOURNAL ARTICLE
Luke Brandenberger, Karly Williams Silva, Fima Macheret, Jenelle Badulak, Jacob A Lebin
No abstract text is available yet for this article.
August 2023: Annals of Emergency Medicine
https://read.qxmd.com/read/37476143/wernicke-encephalopathy-in-a-patient-with-bipolar-disorder-a-case-report
#39
Kateryna Chepenko, Muhammad Humayoun Rashid, Ulviyya Turabova, Tigran Kakhktsyan, Sindhu Chadalawada, Ali Abdulsahib, Aliaa Mousa, Shafaq Bokhari
Wernicke encephalopathy (WE) is a combination of neurological findings including confusion, ataxia, and ophthalmoplegia. It is most commonly associated with patients who have a history of alcohol abuse. This aspect leads to the majority of cases going undiagnosed in non-alcoholic patients who have other potential thiamine deficiency-causing conditions such as malignancy, chronic kidney disease (CKD) on hemodialysis, hyperemesis gravidarum, and psychiatric disorders leading to starvation and malnourishment. Here we present the case of a 59-year-old female patient with decompensated bipolar disorder who came in with altered mental status and multiple syncopal episodes...
June 2023: Curēus
https://read.qxmd.com/read/37470792/a-framework-to-simplify-paediatric-syncope-diagnosis
#40
REVIEW
Julian M Stewart, J Gert van Dijk, Seshadri Balaji, Richard Sutton
This paper aims to improve the diagnosis of syncope and transient loss of consciousness (TLOC) in children. Diagnostic problems stem, first, from some causes spanning various disciplines, e.g. cardiology, neurology and psychiatry, while the most common cause, vasovagal syncope, is not embraced by any specialty. Second, clinical variability is huge with overlapping signs and symptoms. Third, the approach to TLOC/syncope of the European Society of Cardiology (ESC) is underused in childcare. We explain the ESC guidelines using an additional paediatric literature review...
July 20, 2023: European Journal of Pediatrics
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