keyword
https://read.qxmd.com/read/37971748/adipolin-is-a-new-adipokine-in-female-reproduction-expression-and-function-in-porcine-granulosa-cells
#1
JOURNAL ARTICLE
Alix Barbe, Patrycja Kurowska, Christelle Ramé, Pascal Froment, Agnieszka Rak, Joelle Dupont
Adipolin is a recently discovered adipokine that plays an important role in glucose and insulin level regulation. Previous studies showed its reduced level in serum of women suffering from polycystic ovarian syndrome; however, whether adipolin regulates ovary function is still unknown. The aim of study was first to determine the level of adipolin in the porcine ovarian follicles granulosa cells (Gc), and then its in vitro effect on proliferation and steroidogenesis as well as phosphorylation of several signalling pathways...
November 1, 2023: Reproduction
https://read.qxmd.com/read/37562189/expression-of-visfatin-in-the-ovarian-follicles-of-prepubertal-and-mature-gilts-and-in-vitro-effect-of-gonadotropins-insulin-steroids-and-prostaglandins-on-visfatin-levels
#2
JOURNAL ARTICLE
Ewa Mlyczyńska, Patrycja Kurowska, Edyta Rytelewska, Ewa Zaobina, Karolina Pich, Marta Kieżun, Kamil Dobrzyń, Katarzyna Kisielewska, Grzegorz Kopij, Nina Smolińska, Tadeusz Kamiński, Agnieszka Rak
Recent studies have demonstrated that visfatin participates in the regulation of female reproduction. Due to the lack of data concerning the level of visfatin in the ovarian follicles of pigs, one of the most economically important livestock species, the aim of this study was to investigate the expression and localisation of visfatin and the follicular fluid concentration in the ovarian follicles of prepubertal and mature gilts. We also aimed to examine the in vitro effects of gonadotropins (LH, FSH), insulin, progesterone (P4 ), oestradiol (E2 ), prostaglandin E2 (PGE2 ) and F2α (PGF2α ) on visfatin levels...
August 5, 2023: Theriogenology
https://read.qxmd.com/read/37432419/risk-factor-analysis-for-tibial-tubercle-avulsion-fractures-in-children
#3
JOURNAL ARTICLE
Yiwei Wang, Peng Huang, Minjie Fan, Hanjie Zhuang, Ruoyi Guo, Pengfei Zheng, Kai Tang
PURPOSE: Tibial tubercle avulsion fractures (TTAFs) are rare in children, particularly bilateral TTAFs. This study aimed to elucidate the associating factors of TTAF, and compare the risk factor profiles of unilateral and bilateral injuries, thus provide clinical theoretical basis for reducing the occurrence of TTAFs. METHODS: TTAF paediatric patients who were hospitalized between April 2017 and November 2022 were retrospectively analysed. Children who presented for physical examination during the same period were randomly selected, and were age- and sex-matched as controls...
July 11, 2023: International Orthopaedics
https://read.qxmd.com/read/37386803/gender-affirming-hormone-therapy-decreases-d-dimer-but-worsens-insulin-sensitivity-in-transgender-women
#4
JOURNAL ARTICLE
Jordan E Lake, Hongyu Miao, Emily R Bowman, Jesse L Clark, Ana N Hyatt, Aaren Kettelhut, Javier R Lama, Sari L Reisner, Kenneth H Mayer, Amaya Perez-Brumer, Nicholas Funderburg
OBJECTIVES: Gender-affirming hormonal therapies (GAHT) and HIV increase cardiovascular risk for transgender women (TW), yet there is a paucity of data quantifying cardiometabolic changes following GAHT initiation, particularly among TW with HIV. METHODS: The Féminas study enrolled TW from October 2016 to March 2017 in Lima, Peru. Participants reported sexual activity that was high risk for HIV acquisition or transmission. All were tested for HIV/ sexually transmitted infection and were given access to GAHT (oestradiol valerate and spironolactone), HIV pre-exposure prophylaxis (PrEP) or antiretroviral therapy (ART) for 12 months...
June 29, 2023: HIV Medicine
https://read.qxmd.com/read/37155301/galanin-like-peptide-and-its-correlation-with-androgen-levels-in-patients-with-polycystic-ovary-syndrome
#5
JOURNAL ARTICLE
Mustafa Demirpence, Hamiyet Yilmaz Yasar, Inanc Karakoyun, Elif Merve Girgin
INTRODUCTION: We aimed to investigate serum galanin-like peptide (GALP) levels and their correlation with hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS: The study included 48 women (age range, 18-44 years) with a diagnosis of PCOS, and a control group that included 40 healthy females (age range, 18-46 years). Waist circumference, body mass index (BMI), and Ferriman-Gallwey score were evaluated and plasma glucose, lipid profile, oestradiol, progesterone, total testosterone, prolactin, insulin, dehydroepiandrosterone sulphate (DHEA-S), follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), 25-hydroxyvitamin D (25(OH)D), fibrinogen, d-dimer, C-reactive protein (CRP), and GALP levels were measured in all study subjects...
2023: Endokrynologia Polska
https://read.qxmd.com/read/37143096/butyrate-mitigates-metabolic-dysfunctions-via-the-er%C3%AE-ampk-pathway-in-muscle-in-ovx-mice-with-diet-induced-obesity
#6
JOURNAL ARTICLE
Qingsong Fu, Tiantian Li, Chen Zhang, Xiaotian Ma, Liying Meng, Limin Liu, Kai Shao, Guanzhao Wu, Xing Zhu, Xiaoyun Zhao
The higher prevalence of metabolic syndrome (MetS) in women after menopause is associated with a decrease in circulating 17β-oestradiol. To explore novel treatments for MetS in women with oestrogen deficiency, we studied the effect of exogenous butyrate on diet-induced obesity and metabolic dysfunctions using ovariectomized (OVX) mice as a menopause model. Oral administration of sodium butyrate (NaB) reduced the body fat content and blood lipids, increased whole-body energy expenditure, and improved insulin sensitivity...
May 4, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/36694227/effects-of-half-dose-spiomet-treatment-in-girls-with-early-puberty-and-accelerated-bone-maturation-a-multicenter-randomized-placebo-controlled-study-protocol
#7
JOURNAL ARTICLE
Judit Bassols, Francis de Zegher, Marta Diaz, Gemma Carreras-Badosa, Cristina Garcia-Beltran, Elsa Puerto-Carranza, Cora Oliver-Vila, Paula Casano, Céline Alicia Franco, Rita Malpique, Abel López-Bermejo, Lourdes Ibáñez
BACKGROUND: A "mismatch" sequence of less prenatal weight gain and more postnatal weight gain may lead to ectopic lipid accumulation, and trigger the development of early adrenarche/pubarche and the activation of the gonadotropic axis resulting in early puberty and ending up in full-blown adolescent polycystic ovary syndrome (PCOS). In the present study, we assess whether a low-dose combination of generics that collectively reduce ectopic fat through different pathways can slow down the accelerated maturation in "mismatch" girls with early puberty...
January 24, 2023: Trials
https://read.qxmd.com/read/36303231/insulin-like-peptide-5-insl5-positively-correlates-with-anti-m%C3%A3-llerian-hormone-amh-in-women-with-the-polycystic-ovary-syndrome-a-case-control-study
#8
JOURNAL ARTICLE
Yijie Chen, Miao Deng, Zhaojing Chen, Shuyang Han, Jun Chen, Hongyan Zhang, Qianwen Wang, Xuejing Jin, Wenhua Liu, Zhifen Zhang
BACKGROUND: Insulin-like peptide 5 (INSL5) is involved in both reproductive and metabolic processes in polycystic ovary syndrome (PCOS). This study aimed to evaluate the relationship between INSL5 and anti-Müllerian hormone (AMH). METHODS: A retrospective case-control study was conducted in a university-based reproductive centre between December 2019 and January 2021. We included 117 women with PCOS and 100 healthy subjects from Zhejiang Province. All subjects were divided into four groups (1st-4th) based on quartiles of serum INSL5 levels...
October 28, 2022: Journal of Ovarian Research
https://read.qxmd.com/read/35896083/a-randomized-trial-of-the-effect-of-a-gnrh-analogue-injection-on-ghrelin-levels-in-girls
#9
JOURNAL ARTICLE
Maria Rodanaki, Eva Rask, Maria Lodefalk
INTRODUCTION: Ghrelin concentrations decline during puberty by an unclear mechanism. Acylated ghrelin (AG) is unstable in sampling tubes, but no standardized sampling protocol exists. We hypothesized that ghrelin levels decrease as a consequence of increased gonadotropin releasing hormone (GnRH) signalling and that the addition of a protease inhibitor to sampling tubes preserves the AG levels. METHODS: In this randomized, placebo-controlled, cross-over study, 13 girls with suspected central precocious puberty were included...
July 27, 2022: Hormone Research in Pædiatrics
https://read.qxmd.com/read/35738176/sex-hormone-binding-globulin-as-a-potential-drug-candidate-for-liver-related-metabolic-disorders-treatment
#10
REVIEW
Nabila Bourebaba, ThuHa Ngo, Agnieszka Śmieszek, Lynda Bourebaba, Krzysztof Marycz
Sex hormone binding globulin (SHBG) is a hepatokine that binds to circulating steroid hormones (testosterone, oestradiol) to regulate their concentration in the bloodstream. Recently SHBG was recognized as an essential biomarker for metabolic syndrome (MetS) and hepatic steatosis development. At the hepatic level, the production of SHBG is mainly regulated by sex steroids and thyroxine. Studies of various research groups, including ours, showed that SHBG could be considered a reliable marker of insulin resistance and, therefore, can serve as a predictor of type 2 diabetes...
June 20, 2022: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/35399633/effects-of-acupuncture-combined-with-moxibustion-on-reproductive-and-metabolic-outcomes-in-patients-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#11
REVIEW
Peishuang Li, Jiahua Peng, Zhiling Ding, Xu Zhou, Ruining Liang
Objectives: In this systematic review, the effects of acupuncture combined with moxibustion on reproductive and metabolic outcomes in patients with polycystic ovary syndrome (PCOS) were evaluated. Methods: Randomized controlled trials (RCTs) assessing acupuncture combined with moxibustion + basic treatment (experimental group) versus basic treatment alone (control group) for treating PCOS were identified from English and Chinese databases up to November 3, 2021...
2022: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/35339367/microrna-let-7i-inhibits-granulosa-luteal-cell-proliferation-and-oestradiol-biosynthesis-by-directly-targeting-imp2
#12
JOURNAL ARTICLE
Xiao Xu, Hao-Ran Shen, Min Yu, Mei-Rong Du, Xue-Lian Li
RESEARCH QUESTION: Increased granulosa cell division is associated with abnormal folliculogenesis in polycystic ovary syndrome (PCOS). Lethal-7i microRNA (let-7i) may play an important role in the follicular development and granulosa cell growth; therefore is let-7i involved in PCOS pathogenesis? DESIGN: The expression of let-7i was measured in granulosa-luteal cells (GLC) from women with or without PCOS. A human granulosa cell line, KGN, was used for the functional study...
May 2022: Reproductive Biomedicine Online
https://read.qxmd.com/read/35121050/network-pharmacology-integrated-with-experimental-validation-reveals-the-regulatory-mechanism-of-action-of-hehuan-yin-decoction-in-polycystic-ovary-syndrome-with-insulin-resistance
#13
JOURNAL ARTICLE
Yuan-Yuan Wu, Shu-Yu Li, Hui-Qing Zhu, Zi-Ming Zhuang, Meng Shao, Fei-Long Chen, Chang-Shun Liu, Qing-Fa Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Hehuan Yin decoction (HHY), first recorded in the Jingyue Quanshu (published in 1624 A.D.), is composed of Albizia julibrissin Durazz. and Ampelopsis japonica (Thunb.) Makino. AIM OF THE STUDY: This study aimed to investigate the mechanism of action of HHY in treating polycystic ovary syndrome with insulin resistance (PCOS-IR). MATERIALS AND METHODS: Network pharmacology and molecular docking were used to predict active compounds, potential targets, and pathways for PCOS-IR treatment using HHY...
May 10, 2022: Journal of Ethnopharmacology
https://read.qxmd.com/read/34998791/role-of-high-fat-diet-on-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#14
JOURNAL ARTICLE
Nazia Begum, Kandavalli Manipriya, B Veeresh
Polycystic ovary syndrome (PCOS) is one of the most prevalent hormonal disorders in women of reproductive age. Letrozole (LET)-induced PCOS is a good model but has drawbacks such as the absence of metabolic changes. Hence, in the present study, we aimed to develop a new animal model combining a high-fat diet (HFD) and LET. Female Wistar rats were divided into a control group, LET group, and LET + HFD (45% energy from fat) group. Compared with the control group, the LET and LET + HFD groups showed ovarian cysts and elevated testosterone levels, whereas oestradiol and progesterone levels were reduced...
February 15, 2022: European Journal of Pharmacology
https://read.qxmd.com/read/34937983/the-effect-of-the-menstrual-cycle-on-collagen-metabolism-growth-hormones-and-strength-in-young-physically-active-women
#15
JOURNAL ARTICLE
Dagmara Iwańska, Anna Kęska, Emilia Dadura, Agnieszka Wójcik, Andrzej Mastalerz, Czesław Urbanik
This study aimed to investigate the effect of the menstrual cycle on strength, functioning of the GH/IGF-1 axis and collagen metabolism in physically active women. Twenty-four physically active and eumenorrheic women volunteered to participate in the study (body mass 60.3 ± 9.18 kg, age 21.8 ± 0.92 years). Blood samples were obtained between the 5th and 8th days (the follicular phase) and between the 19th and 22th days (the luteal phase) of the menstrual cycle to determine sex steroid concentrations (follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), oestradiol (E2) and progesterone (P))...
October 2021: Biology of Sport
https://read.qxmd.com/read/34607837/alcohol-intake-and-endogenous-hormones-in-pre-and-postmenopausal-women-findings-from-the-uk-biobank
#16
JOURNAL ARTICLE
Sandar Tin Tin, Timothy J Key, Gillian K Reeves
BACKGROUND: Alcohol intake may influence breast cancer risk in women through hormonal changes, but the evidence to date is inconclusive. We investigated cross-sectional associations between habitual alcohol intake and serum concentrations of testosterone, sex hormone binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), and estradiol (premenopausal women only) in UK Biobank. METHODS: We included 30,557 premenopausal and 134,029 postmenopausal women aged between 40 and 69 years when recruited between 2006 and 2010...
December 2021: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/34490645/hypothalamic-pituitary-gonadal-axis-and-sexual-functioning-in-metformin-treated-men-after-discontinuation-of-testosterone-replacement-therapy-a-pilot-study
#17
JOURNAL ARTICLE
Robert Krysiak, Karolina Kowalcze, Bogusław Okopień
WHAT IS KNOWN AND OBJECTIVE: Metformin was found to reduce elevated gonadotropin levels. The aim of the present study was to determine whether metformin modulates the impact of discontinuation of testosterone therapy on hypothalamic-pituitary-gonadal axis activity and sexual function in men with low testosterone levels. METHODS: The study included 28 men with late-onset hypogonadism (defined according to the criteria of the European Male Aging Study group) receiving testosterone undecanoate (120 mg in three equal doses), 12 of whom had been treated with oral metformin (1...
December 2021: Journal of Clinical Pharmacy and Therapeutics
https://read.qxmd.com/read/34371064/ovarian-insufficiency-impairs-glucose-stimulated-insulin-secretion-through-activation-of-hypothalamic-de-novo-ceramide-synthesis
#18
JOURNAL ARTICLE
Kelly Meneyrol, Ánxela Estévez-Salguero, Ismael González-García, Jeanne Guitton, Mohammed Taouis, Yacir Benomar, Christophe Magnan, Miguel López, Hervé Le Stunff
Oestrogens regulate body weight through their action on hypothalamus to modulate food intake and energy expenditure. Hypothalamic de novo ceramide synthesis plays a central role on obesity induced by oestrogen deficiency. Depletion in oestrogens is also known to be associated with glucose intolerance, which favours type 2 diabetes (T2D). However, the implication of hypothalamic ceramide in the regulation of glucose homeostasis by oestrogen is unknown. Here, we studied glucose homeostasis and insulin secretion in ovariectomized (OVX) female rats...
October 2021: Metabolism: Clinical and Experimental
https://read.qxmd.com/read/34314376/expression-and-role-of-resistin-on-steroid-secretion-in-the-porcine-corpus-luteum
#19
JOURNAL ARTICLE
Patrycja Kurowska, Monika Sroka, Monika Dawid, Ewa Mlyczyńska, Natalia Respekta, Małgorzata Jurek, Dominika Klimczyk, Małgorzata Grzesiak, Joelle Dupont, Agnieszka Rak
Resistin plays an important role in adipogenesis, obesity, insulin resistance, and reproduction. Previous studies showed resistin action on ovarian follicular cells; however, whether resistin regulates steroid secretion in luteal cells is still unknown. Our aim was first to determine the expression of resistin and its potential receptors (tyrosine kinase-like orphan receptor 1 (ROR1) and toll-like receptor 4 (TLR4)) in the porcine corpus luteum (CL), regulation of its expression, effect on kinases phosphorylation, and luteal steroidogenesis...
September 6, 2021: Reproduction
https://read.qxmd.com/read/33864017/endogenous-hormones-and-risk-of-invasive-breast-cancer-in-pre-and-post-menopausal-women-findings-from-the-uk-biobank
#20
JOURNAL ARTICLE
Sandar Tin Tin, Gillian K Reeves, Timothy J Key
BACKGROUND: Some endogenous hormones have been associated with breast cancer risk, but the nature of these relationships is not fully understood. METHODS: UK Biobank was used. Hormone concentrations were measured in serum collected in 2006-2010, and in a repeat subsample (N ~ 5000) in 2012-13. Incident cancers were identified through data linkage. Cox regression models were used, and hazard ratios (HRs) corrected for regression dilution bias. RESULTS: Among 30,565 pre-menopausal and 133,294 post-menopausal women, 527 and 2,997, respectively, were diagnosed with invasive breast cancer during a median follow-up of 7...
July 2021: British Journal of Cancer
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