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https://www.readbyqxmd.com/read/27901601/activation-of-estrogen-response-element-independent-er%C3%AE-signaling-protects-female-mice-from-diet-induced-obesity
#1
Ali Yasrebi, Janelle A Rivera, Elizabeth A Krumm, Jennifer A Yang, Troy A Roepke
17β-estradiol (E2) regulates central and peripheral mechanisms that control energy and glucose homeostasis predominantly through estrogen receptor α (ERα) acting via receptor binding to estrogen response elements (ERE). ERα signaling is also involved in mediating the effects of E2 on diet-induced obesity (DIO), although the roles of ERE-dependent and -independent ERα signaling in ameliorating the effects of DIO remain largely unknown. We hypothesize that ERE-dependent ERα signaling is necessary to ameliorate the effects of DIO...
November 30, 2016: Endocrinology
https://www.readbyqxmd.com/read/27901182/does-insulin-resistance-increase-thyroid-volume-in-patients-with-polycystic-ovary-syndrome
#2
Murat Sahin, Didem Demircioglu, Ayten Oguz, Dilek Tuzun, Mehmet Akif Sarica, Elif Inanc, Kamile Gul
Objective: To investigate the effect of gonadotropin, sex hormone levels and insulin resistance (IR) on thyroid functions and thyroid volume (TV) in polycystic ovary syndrome (PCOS). Subjects and methods: 69 new diagnosed PCOS patients (age 24.82 ± 6.17) and 56 healthy control female (age 26.69 ± 5.25) were involved to the study. Fasting plasma glucose, lipid profile, insulin, thyroid stimulating hormone (TSH), free thyroxine (fT4), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone levels and urine iodine were measured in all participants...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27898988/lipid-accumulation-product-lap-as-an-index-of-metabolic-and-hormonal-disorders-in-aging-men
#3
I Rotter, A Rył, A Szylińska, W Pawlukowska, A Lubkowska, M Laszczyńska
Lipid accumulation product (LAP) is an index used for evaluating lipid overaccumulation in adults. Our study aimed at assessing associations between LAP and metabolic syndrome (MetS) and its components, age-related testosterone deficiency syndrome (TDS), low-density cholesterol (LDL), as well as HOMA-IR (insulin resistance ratio), insulin level in non-diabetics and total testosterone (TT), estradiol E2, dehydroepiandrosterone sulphate (DHEAs) and sex hormone-binding globulin (SHBG) in aging men.313 men aged 50-75 were surveyed with regard to the prevalence of diabetes (T2DM) and hypertension (HT)...
November 29, 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27898283/pregestational-type-2-diabetes-and-gestational-diabetes-exhibit-different-sexual-steroid-profiles-during-pregnancy
#4
Claudio Villarroel, Abril Salinas, Patricia López, Paulina Kohen, Gustavo Rencoret, Luigi Devoto, Ethel Codner
Higher androgen levels are observed in non-pregnant women with diabetes. Whether this hormonal profile is found during pregnancy is unknown. The aim of this study was to determine the sexual steroids levels in pregnant women with pregestational type 2 (T2D) and gestational diabetes (GD) compared to healthy control (C) pregnant women during the second half of pregnancy. A prospective study of 69 pregnant women with T2D (n = 21), GD (n = 24) and control (C, n = 24) was followed up during the second half of gestation...
November 29, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27865406/an-adverse-immune-endocrine-profile-in-patients-with-tuberculosis-and-type-2-diabetes
#5
R Fernández, A Díaz, L D'Attilio, B Bongiovanni, N Santucci, D Bertola, H Besedovsky, A Del Rey, M L Bay, O Bottasso
Diabetes is a risk factor for the development of pulmonary tuberculosis (TB) and both diseases present endocrine alterations likely to play a role in certain immuno-endocrine-metabolic associated disorders. Patients with TB, or with TB and type 2 diabetes (TB + T2DM) and healthy controls (HCo) were assessed for plasma levels of cortisol, dehydroepiandrosterone (DHEA), estradiol, testosterone, growth hormone (GH), prolactin, insulin-like growth factor-1 (IGF-1), cytokines (IL-6, IL-10, IFN-γ) and the specific lymphoproliferative capacity of peripheral blood mononuclear cells...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27855752/sleep-characteristics-and-carotid-atherosclerosis-among-midlife-women
#6
Rebecca C Thurston, Yuefang Chang, Roland von Känel, Emma Barinas-Mitchell, J Richard Jennings, Martica H Hall, Nanette Santoro, Daniel J Buysse, Karen A Matthews
STUDY OBJECTIVES: Midlife, which encompasses the menopause transition in women, can be a time of disrupted sleep and accelerated atherosclerosis accumulation. Short or poor sleep quality has been associated with cardiovascular disease (CVD) risk; few studies have investigated relations among midlife women. We tested whether shorter actigraphy sleep time or poorer subjective sleep quality was associated with carotid atherosclerosis among midlife women. METHODS: 256 peri- and postmenopausal women aged 40-60 completed three days of wrist actigraphy, hot flash monitoring, questionnaires [Pittsburgh Sleep Quality Index (PSQI), Berlin], a blood draw, and carotid ultrasound [intima media thickness (IMT), plaque]...
November 14, 2016: Sleep
https://www.readbyqxmd.com/read/27843797/does-endothelial-dysfunction-correlate-with-endocrinal-abnormalities-in-patients-with-polycystic-ovary-syndrome
#7
REVIEW
Rajani Dube
To study and critically analyze the published evidence on correlation of hormonal abnormalities and endothelial dysfunction (ED) in polycystic ovary syndrome (PCOS) through a systematic review. The databases including MEDLINE, PubMed, Up-To-Date, and Science Direct were searched using Medical subject handling terms and free text term keywords such as endocrine abnormalities in PCOS, ED assessment in PCOS, ED in combination with insulin resistance (IR), hyperandrogenism (HA), increased free testosterone, free androgen index (FAI), gonadotrophin levels, luteinizing hormone (LH), prolactin, estrogen, adipocytokines to search trials, and observational studies published from January 1987 to September 2015...
October 2016: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/27837347/tamoxifen-resistance-and-metastasis-of-human-breast-cancer-cells-were-mediated-by-the-membrane-associated-estrogen-receptor-er-%C3%AE-36-signaling-in-vitro
#8
Wenwen Gu, Nian Dong, Peng Wang, Changgen Shi, Jun Yang, Jian Wang
The drug resistance and tumor metastasis have been the main obstacles for the longer-term therapeutic effects of tamoxifen (TAM) on estrogen receptor-positive (ER(+)) breast cancer, but the mechanisms underlying the TAM resistance are still unclear. Here, we demonstrated that the membrane-associated estrogen receptor ER-α36 signaling, but not the G protein-coupled estrogen receptor 1 (GPER1) signaling, might be involved in the TAM resistance and metastasis of breast cancer cells. In this study, a model of ER(+) breast cancer cell MCF-7 that involves the up-regulated expression of ER-α36 and unchanged expression of ER-α66 and GPER1 was established via the removal of insulin from the cell culture medium...
November 11, 2016: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/27831918/17%C3%AE-estradiol-suppresses-visceral-adipogenesis-and-activates-brown-adipose-tissue-specific-gene-expression
#9
Saad Misfer Al-Qahtani, Galyna Bryzgalova, Ismael Valladolid-Acebes, Marion Korach-André, Karin Dahlman-Wright, Suad Efendić, Per-Olof Berggren, Neil Portwood
Both functional ovaries and estrogen replacement therapy (ERT) reduce the risk of type 2 diabetes (T2D). Understanding the mechanisms underlying the antidiabetic effects of 17β-estradiol (E2) may permit the development of a molecular targeting strategy for the treatment of metabolic disease. This study examines how the promotion of insulin sensitivity and weight loss by E2 treatment in high-fat-diet (HFD)-fed mice involve several anti-adipogenic processes in the visceral adipose tissue. Magnetic resonance imaging (MRI) revealed specific reductions in visceral adipose tissue volume in HFD+E2 mice, compared with HFD mice...
November 10, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27814578/lipid-raft-er-signalosome-malfunctions-in-menopause-and-alzheimer-s-disease
#10
Ana Canerina-Amaro, Luis G Hernandez-Abad, Isidre Ferrer, David Quinto-Alemany, Fatima Mesa-Herrera, Carla Ferri, Ricardo A Puertas-Avendano, Mario Diaz, Raquel Marin
The increase in the incidence of Alzheimer's disease (AD) in old women may be attributable to estrogen deficiency, and estrogen replacement therapy may be useful in preventing or delaying the onset of this disease. In neuronal membranes, 17 beta-estradiol interacts with estrogen receptors (mERs) located in lipid raft signalosomes which trigger neuroprotective responses by anchoring to scaffolding caveolin-1 complexed with other proteins. We suggest that mER-signalosome malfunctions in AD and by menopause due to development of aberrations in these microstructures...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27807711/evidences-for-involvement-of-growth-hormone-and-insulin-like-growth-factor-in-ovarian-development-of-starry-flounder-platichthys-stellatus
#11
Yongjiang Xu, Bin Wang, Xuezhou Liu, Bao Shi, Kun Zang
Although gonadotrophins are major regulators of ovarian function in teleosts and other vertebrates, accumulating evidence indicates that the growth hormone (GH)-insulin-like growth factor (IGF) axis also plays an important role in fish reproduction. As a first step to understand the physiological role of the GH-IGF system in the ovarian development of starry flounder (Platichthys stellatus), the expression profiles of GH and IGF messenger RNAs (mRNAs) and plasma GH, IGF-I, estradiol-17β (E2), and testosterone (T) levels during the ovarian development were investigated...
November 2, 2016: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/27802175/neurotransmitter-alteration-in-a-testosterone-propionate-induced-polycystic-ovarian-syndrome-rat-model
#12
Nirja K Chaudhari, Laxmipriya P Nampoothiri
BACKGROUND: Polycystic ovarian syndrome (PCOS), one of the leading causes of infertility seen in women, is characterized by anovulation and hyperandrogenism, resulting in ovarian dysfunction. In addition, associations of several metabolic complications like insulin resistance, obesity, dyslipidemia and psychological co-morbidities are well known in PCOS. One of the major factors influencing mood and the emotional state of mind is neurotransmitters. Also, these neurotransmitters are very crucial for GnRH release...
October 29, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27798951/associations-between-adherence-to-the-world-cancer-research-fund-american-institute-for-cancer-research-cancer-prevention-recommendations-and-biomarkers-of-inflammation-hormonal-and-insulin-response
#13
Fred K Tabung, Teresa T Fung, Jorge E Chavarro, Stephanie A Smith-Warner, Walter C Willett, Edward L Giovannucci
Adherence to the 2007 WCRF/AICR cancer prevention recommendations has been associated with lower cancer risk but the underlying biological mechanisms have not been elucidated. We utilized dietary and lifestyle data from 11,342 women in the Nurses' Health Study and 8,136 men in the Health Professionals Follow-up Study, to investigate associations between adherence scores and markers of inflammation, hormonal and insulin response. Two scores ranging from 0 to 3 were constructed to assess adherence to the energy balance-related recommendations (weight management, physical activity, energy density); and the plant, animal foods and alcohol intake recommendations; with higher scores indicating greater adherence...
October 31, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27793387/effect-of-pregnancy-associated-plasma-protein-a-papp-a-single-nucleotide-polymorphisms-on-the-level-and-activity-of-papp-a-and-the-hormone-profile-in-fluid-from-normal-human-small-antral-follicles
#14
Jane Alrø Bøtkjær, Tanni Borgbo, Søren Kløverpris, Pernille Rimmer Noer, Claus Oxvig, Claus Yding Andersen
OBJECTIVE: To reveal a possible relationship between two single nucleotide polymorphisms (SNPs) in PAPP-A-1224 (rs7020782) and 327 (rs12375498)-and the level and activity of PAPP-A in follicular fluid (FF) of human small antral follicles, and to analyze the intrafollicular hormone levels. DESIGN: Laboratory investigation. SETTING: University hospital. PATIENT(S): Fifty volunteer women who contributed a total of 210 samples of FF from normal small antral follicles...
October 25, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27790765/acupuncture-does-not-restore-metabolic-disturbances-in-the-p450-aromatase-inhibitor-induced-polycystic-ovary-syndrome-rat-model
#15
Manuel Maliqueo, Anna Benrick, Rodrigo Rodrigues Marcondes, Julia Johansson, Miao Sun, Elisabet Stener-Victorin
Low-frequency electroacupuncture restores sex steroid synthesis and sympathetic activity in women with polycystic ovary syndrome, which may improve its metabolic disturbances likely by modulating sympathetic nerve activity or sex steroid synthesis. We investigated whether low-frequency electroacupuncture regulates the metabolic function to the same extent as treatment with estradiol or β-adrenergic blocking in a rat model of polycystic ovary syndrome induced by a P450 aromatase inhibitor (letrozole). Letrozole (200 μg per day) or placebo pellets were implanted in pre-pubertal Wistar rats...
October 28, 2016: Experimental Physiology
https://www.readbyqxmd.com/read/27776987/endocrinology-of-aging-from-a-muscle-function-point-of-view-results-from-the-toledo-study-for-healthy-aging
#16
Amelia Guadalupe-Grau, Jose Antonio Carnicero, Jose Losa-Reyna, Jesús Tresguerres, Maria Del Carmen Gómez-Cabrera, Carmen Castillo, Ana Alfaro-Acha, Cristina Rosado-Artalejo, Leocadio Rodriguez-Mañas, Francisco José García-García
INTRODUCTION: Aging is a process that involves a reduction in muscle strength and anabolic hormone concentrations, which impacts significantly on health. AIM: To study the hormone/total strength (H/TS) ratio as a proxy of anabolic insensitivity status in elders, and its relationship with disability, hospitalization, and mortality risk. DESIGN: A total of 1462 persons aged ≥65 years from the Toledo Study of Healthy Aging participated in this study...
October 21, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27775654/germinated-pigmented-rice-oryza-sativa-l-cv-superhongmi-improves-glucose-and-bone-metabolisms-in-ovariectomized-rats
#17
Soo Im Chung, Su Noh Ryu, Mi Young Kang
The effect of germinated Superhongmi, a reddish brown pigmented rice cultivar, on the glucose profile and bone turnover in the postmenopausal-like model of ovariectomized rats was determined. The ovariectomized Sprague-Dawley rats were randomly divided into three dietary groups (n = 10): normal control diet (NC) and normal diet supplemented with non-germinated Superhongmi (SH) or germinated Superhongmi (GSH) rice powder. After eight weeks, the SH and GSH groups showed significantly lower body weight, glucose and insulin concentrations, levels of bone resorption markers and higher glycogen and 17-β-estradiol contents than the NC group...
October 21, 2016: Nutrients
https://www.readbyqxmd.com/read/27771529/the-effect-of-oral-contraception-on-cardiometabolic-risk-factors-in-women-with-elevated-androgen-levels
#18
Robert Krysiak, Małgorzata Gilowska, Bogusław Okopień
BACKGROUND: In unselected reproductive-aged women, use of combined estrogen-progestin oral contraceptive pills has been linked with an increased risk of vascular disease. The aim of this study was to investigate the effect of oral contraception on cardiometabolic risk factors in a population of women with hyperandrogenism. METHODS: The study included 16 untreated women with elevated testosterone levels and 15 matched healthy women who were then treated with oral contraceptive pills containing ethinyl estradiol (30μg) and drospirenone (3mg)...
September 15, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27770396/insulin-resistance-elicited-in-postpubertal-primate-offspring-deprived-of-estrogen-in-utero
#19
Gerald J Pepe, Adina Maniu, Graham Aberdeen, Terrie J Lynch, Soon Ok Kim, Jerry Nadler, Eugene D Albrecht
We recently demonstrated that offspring delivered to baboons deprived of estrogen during the second half of gestation exhibited insulin resistance prior to onset of puberty. Because gonadal hormones have a profound effect on insulin action and secretion in adults, we determined whether insulin resistance is retained after initiation of gonadal secretion of testosterone and estradiol. Glucose tolerance tests were performed in postpubertal baboon offspring of untreated and letrozole-treated animals (serum estradiol reduced >95 %)...
October 21, 2016: Endocrine
https://www.readbyqxmd.com/read/27760898/activation-of-g-protein-coupled-estrogen-receptor-1-mimics-but-does-not-mediate-the-anti-proliferative-action-of-estradiol-on-pituitary-lactotrophs-in-primary-culture
#20
Tetsuo Mitsui, Maho Ishida, Michi Izawa, Jun Arita
Estrogen binds to nuclear estrogen receptors (ERs) to modulate transcription of target genes in estrogen-responsive cells. However, recent studies have shown that estrogen also binds to cytoplasmic membrane ERs to modulate protein kinase signaling cascades, leading to non-genomic actions. We investigated whether either nuclear or membrane ERs, including G protein-coupled estrogen receptor 1 (Gper1), mediate the inhibitory action of estrogen on insulin-like growth factor-1 (IGF-1)-induced proliferation of pituitary lactotrophs in primary culture...
October 19, 2016: Endocrine Journal
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