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https://www.readbyqxmd.com/read/28333238/clustering-of-pcos-like-traits-in-naturally-hyperandrogenic-female-rhesus-monkeys
#1
D H Abbott, B H Rayome, D A Dumesic, K C Lewis, A K Edwards, K Wallen, M E Wilson, S E Appt, J E Levine
STUDY QUESTION: Do naturally occurring, hyperandrogenic (≥1 SD of population mean testosterone, T) female rhesus monkeys exhibit traits typical of women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Hyperandrogenic female monkeys exhibited significantly increased serum levels of androstenedione (A4), 17-hydroxyprogesterone (17-OHP), estradiol (E2), LH, antimullerian hormone (AMH), cortisol, 11-deoxycortisol and corticosterone, as well as increased uterine endometrial thickness and evidence of reduced fertility, all traits associated with PCOS...
March 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28329361/sex-hormones-affect-outcome-in-arrhythmogenic-right-ventricular-cardiomyopathy-dysplasia-from-a-stem-cell-derived-cardiomyocyte-based-model-to-clinical-biomarkers-of-disease-outcome
#2
Deniz Akdis, Ardan M Saguner, Khooshbu Shah, Chuanyu Wei, Argelia Medeiros-Domingo, Arnold von Eckardstein, Thomas F Lüscher, Corinna Brunckhorst, H S Vincent Chen, Firat Duru
Aims: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is characterized by fibrofatty infiltration of the myocardium and ventricular arrhythmias that may lead to sudden cardiac death. It has been observed that male patients develop the disease earlier and present with more severe phenotypes as compared to females. Thus, we hypothesized that serum levels of sex hormones may contribute to major arrhythmic cardiovascular events (MACE) in patients with ARVC/D. Methods and results: The serum levels of five sex hormones, sex hormone-binding globulin, high sensitivity troponin T, pro-brain natriuretic peptide, cholesterol, triglycerides, insulin, and glucose were measured in 54 ARVC/D patients (72% male)...
February 18, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28326352/aging-lifestyle-factors-hormones-and-bone-health-in-singaporean-men
#3
Victor Hng Hang Goh, William George Hart
PURPOSE: The present study examined how age, bodyweight, body fat, regular exercise and some endocrine factors are associated with osteoporosis, spine bone mineral density (Sbmd) and femoral neck bone mineral density (Fnbmd) in Singaporean men. METHODS: Body composition and bone scans of lumbar spine at L2-L4 and hip were carried out with duel-energy X-ray absorptiometry (DXA). Anthropometric parameters were measured and demographic data, medical history and exercise schedule were collected via a questionnaire...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28323934/menopausal-hormone-therapy-and-type-2-diabetes-prevention-evidence-mechanisms-and-clinical-implications
#4
Franck Mauvais-Jarvis, JoAnn E Manson, John C Stevenson, Vivian A Fonseca
Type 2 diabetes has reached epidemic proportions in the US. Large randomized controlled trials suggest that menopausal hormone therapy (MHT) delays the onset of type 2 diabetes in women. Still, the mechanisms and clinical implications of these associations are a matter of controversy. This review provides an up-to-date analysis and integration of epidemiological, clinical and basic studies, and proposes a mechanistic explanation for the effect of menopause and MHT on type 2 diabetes development and prevention...
March 8, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28300542/elevated-insulin-and-reduced-insulin-like-growth-factor-binding-protein-3-prostate-specific-antigen-ratio-with-increase-in-prostate-size-in-benign-prostatic-hyperplasia
#5
Karli Sreenivasulu, Hanumanthappa Nandeesha, Lalgudi Narayanan Dorairajan, Medha Rajappa, Vickneshwar Vinayagam
BACKGROUND: Insulin and insulin like growth factor-1 (IGF-1) have growth promoting effects, while insulin like growth factor binding protein-3 (IGFBP-3) has growth inhibitory effects. The present study was designed to assess the concentrations of insulin, IGF-1, IGFBP-3 and their association with prostate size in patients with BPH. METHODS: Ninety 90 BPH cases and 90 controls were enrolled in the study. Insulin, IGF-1, IGFBP-3, PSA, testosterone and estradiol were estimated in both the groups...
March 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28279229/human-umbilical-cord-mesenchymal-stem-cells-improve-the-reserve-function-of-perimenopausal-ovary-via-a-paracrine-mechanism
#6
Jia Li, QiuXian Mao, JingJun He, HaoQing She, Zhi Zhang, ChunYan Yin
BACKGROUND: Human umbilical cord mesenchymal stem cells (hUCMSCs) are a type of pluripotent stem cell which are isolated from the umbilical cord of newborns. hUCMSCs have great therapeutic potential. We designed this experimental study in order to investigate whether the transplantation of hUCMSCs can improve the ovarian reserve function of perimenopausal rats and delay ovarian senescence. METHOD: We selected naturally aging rats confirmed by vaginal smears as models of perimenopausal rats, divided into the control group and the treatment group, and selected young fertile female rats as normal controls...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28270036/fibroblast-growth-factor-7-regulates-proliferation-and-decidualization-of-human-endometrial-stromal-cells-via-erk-and-jnk-pathway-in-an-autocrine-manner
#7
Wen-Jie Zhou, Xin-Xin Hou, Xiao-Qiu Wang, Da-Jin Li
Decidualization is an essential activity of the endometrium in pregnancy, but the molecular mechanisms involving the initiation and maintenance have not yet been clarified. In the present study, we examined the expression of fibroblast growth factor 7 (FGF7) in endometria, normal decidua, and abortion decidua from miscarriage by immunohistochemistry. We analyzed the expression of FGF7 and FGFR2 and the levels of phosphorylated extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinase (JNK) in endometrial stromal cells (ESCs), and decidual stromal cells (DSCs) from early pregnancy or miscarriage by In-Cell Western assay...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28256392/endometrial-cancer-associated-biomarkers-in-bariatric-surgery-candidates-exploration-of-racial-differences
#8
Faina Linkov, Sharon L Goughnour, Robert P Edwards, Anna Lokshin, Ramesh C Ramanathan, Giselle G Hamad, Carol McCloskey, Dana H Bovbjerg
BACKGROUND: Obesity is the main risk factor for endometrial cancer (EC), the most common gynecologic malignancy in the United States. A number of potential risk biomarkers have been associated with EC development, including altered proinflammatory cytokines, chemokines, and adipokines. OBJECTIVES: The overarching aim of this research is to investigate racial differences in the expression of EC-associated biomarkers among bariatric surgery candidates. SETTING: Tertiary academic medical center METHODS: Blood samples were collected from 175 women aged 18 to 72 (mean age: 42...
January 13, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28246273/added-value-of-serum-hormone-measurements-in-risk-prediction-models-for-breast-cancer-for-women-not-using-exogenous-hormones-results-from-the-epic-cohort
#9
Anika Husing, Renee T Fortner, Tilman Kuhn, Kim Overvad, Anne Tjonneland, Anja Olsen, Marie-Christine Boutron-Ruault, Gianluca Severi, Agnes Fournier, Heiner Boeing, Antonia Trichopoulou, Vassiliki Benetou, Philippos Orfanos, Giovanna Masala, Valeria Pala, Rosario Tumino, Francesca Fasanelli, Salvatore Panico, H Bas Bueno-de-Mesquita, Petra Peeters, Carla H van Gils, J Ramon Quiros, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Aurelio Barricarte, Pilar Amiano, Kay-Tee Khaw, Ruth C Travis, Laure Dossus, Kuanrong Li, Pietro Ferrari, Melissa A Merritt, Ioanna Tzoulaki, Elio Riboli, Rudolf Kaaks
PURPOSE: Circulating hormone concentrations are associated with breast cancer risk, with well-established associations for postmenopausal women. Biomarkers may represent minimally invasive measures to improve risk prediction models. EXPERIMENTAL DESIGN: We evaluated improvements in discrimination gained by adding serum biomarker concentrations to risk estimates derived from risk prediction models developed by Gail et al. and Pfeiffer et al. using a nested case-control study within the EPIC cohort including 1217 breast cancer cases and 1976 matched controls...
February 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28241734/tetragonia-tetragonioides-pall-kuntze-protects-estrogen-deficient-rats-against-disturbances-of-energy-and-glucose-metabolism-and-decreases-proinflammatory-cytokines
#10
Jin Ah Ryuk, Byoung-Seob Ko, Hye Won Lee, Da Sol Kim, Suna Kang, Yong Hyen Lee, Sunmin Park
Tetragonia tetragonioides (Pall.) Kuntze (TTK) and JakYakGamCho-Tang (JGT) have been used for improving women's health and treating inflammatory diseases. We determined that the long-term consumption of these herbal extracts alleviates the progression of postmenopausal symptoms in high-fat-diet fed ovariectomized (OVX) rats, and further explored the mechanisms involved. Five groups of OVX rats were fed high fat diets that were supplemented with either 2% dextrin (control), 2% TTK (70% ethanol extract), 2% JGT (water extract), 1% JGT + 1% TTK (JGTT), or 30 µg/kg body weight/day of 17β-estradiol (positive control)...
March 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28228318/endocrine-and-cardiometabolic-cord-blood-characteristics-of-offspring-born-to-mothers-with-and-without-polycystic-ovary-syndrome
#11
Nadine M P Daan, Maria P H Koster, Regine P Steegers-Theunissen, Marinus J C Eijkemans, B C J M Fauser
OBJECTIVE: To compare the endocrine and cardiometabolic cord blood characteristics of offspring of mothers with polycystic ovary syndrome (PCOS) with those of healthy controls. DESIGN: Cross-sectional case control study. SETTING: University medical centers. PATIENT(S): Offspring from mothers with PCOS (n = 61) and healthy controls (n = 82). INTERVENTION(S): Cord blood withdrawal from neonates. MAIN OUTCOME MEASURE(S): Cord blood estradiol, androstenedione, dehydroepiandrosterone sulfate (DHEAS), testosterone, sex hormone-binding globulin, free androgen index (FAI), insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, c-reactive protein, adiponectin, and leptin...
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28211546/differential-effects-of-hormones-on-cellular-metabolism-in-keratoconus-in-vitro
#12
Tina B McKay, Jesper Hjortdal, Henrik Sejersen, Dimitrios Karamichos
Keratoconus (KC) is a corneal thinning disease with an onset commonly immediately post-puberty and stabilization by 40 to 50 years of age. The role of hormones in regulating corneal tissue structure in homeostatic and pathological conditions is unknown. Our group recently linked altered hormone levels to KC. Our current study sought to investigate and delineate the effects of exogenous hormones, such as androgen, luteotropin, and estrogen, on corneal stroma bioenergetics. We utilized our established 3D in vitro model to characterize the effects of DHEA, prolactin, 17β-estradiol on insulin-growth factor-1 and -2 (IGF-1, -2) signaling and metabolic function in primary corneal fibroblasts from healthy controls (HCFs) and KC patients (HKCs)...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211029/influence-of-segmental-body-composition-and-adiposity-hormones-on-resting-metabolic-rate-and-substrate-utilization-in-overweight-and-obese-adults
#13
K R Hirsch, A E Smith-Ryan, M N M Blue, M G Mock, E T Trexler
PURPOSE: Low resting metabolic rate (RMR) and high carbohydrate reliance at rest are associated with weight gain, but are highly variable in obese individuals. This study determined the relationship of total and segmental body composition and adiposity hormones with RMR and respiratory exchange ratio (RER) in overweight and obese adults. METHODS: In 49 men (n = 23) and premenopausal women (n = 26) [mean ± SD; age = 35.0 ± 8.9 years; body mass index (BMI) = 33...
February 16, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28195989/time-since-menopause-and-skeletal-muscle-estrogen-receptors-pgc-1%C3%AE-and-ampk
#14
Young-Min Park, Rocio I Pereira, Christopher B Erickson, Tracy A Swibas, Chounghun Kang, Rachael E Van Pelt
OBJECTIVE: Short-term administration of estradiol (E2) improves insulin-stimulated glucose disposal rate in early postmenopausal (EPM) women compared with a reduction in late postmenopausal (LPM) women. The underlying mechanisms by which E2 action on glucose disposal rate reversed from beneficial early to harmful late in menopause is unknown, but might include adverse changes in estrogen receptors (ERs) or other biomarkers of cellular energy metabolism with age or duration of estrogen deficiency...
February 13, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28185934/corticosteroids-deeply-depress-the-in-vitro-steroidogenic-capacity-of-eurasian-perch-ovary-at-the-end-of-the-reproductive-cycle
#15
S N M Mandiki, S Milla, S Nkogo Robles, P Kestemont
Corticosteroids play positive or negative role in the reproductive mechanisms of many fish species but the physiological contexts relating to such biphasic actions are not well defined. In the present study we investigated to what extent corticosteroids (cortisol-Co, 11-deoxycorticosterone-DOC) hormones may interfere with the steroidogenic capacity of Eurasian perch ovarian tissues, and we tested whether the negative effects of corticosteroids may be mitigated by potential stimulating endocrine factors, namely insulin-like growth factor-1 (IGF), human chorionic gonadotropin (HCG) or thyroid hormones (Triidothyronine-T3, thyroxine-T4)...
February 7, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28182286/maternal-cinnamon-extract-intake-during-lactation-leads-to-sex-specific-endocrine-modifications-in-rat-offspring
#16
Thais Bento-Bernardes, Fernanda P Toste, Carmen C Pazos-Moura, Karen J Oliveira
BACKGROUND: Cinnamon supplementation has been associated with improvement in glucose disposal and reduction in fat mass in type 2 diabetes. Maternal nutrition during lactation impacts the health of the offspring throughout life. We hypothesize that cinnamon intake by lactating rats affects maternal physiology, leading to hormonal and metabolic changes in their offspring. To investigate this hypothesis, dams received aqueous cinnamon extract (400 mg cinnamon/kg body mass/day) or water orally, during lactation...
February 9, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28166977/caloric-restriction-and-igf-i-administration-promote-rabbit-fecundity-possible-interrelationships-and-mechanisms-of-action
#17
Alexander V Sirotkin, Iveta Koničková Florkovičová, Olga Østrup Švarcová, Jan Rafay, Jozef Laurincik, Abdel Halim Harrath
The aim of these in vivo and in vitro studies was to examine the influence of caloric restriction (CR), and the administration of insulin-like growth factor (IGF-I), on rabbit fecundity and to understand the interrelationships between CR and IGF-I, as well as the endocrine and intracellular mechanisms of their effects. Female rabbits were subjected to 50% CR, injections of IGF-I (20 μg/animal/day) and a combination of the two for 10 d before and 2 d after ovulation induced by 25 IU PMSG and 0.25 IU hCG...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28164755/regulation-of-na-k-atpase-by-estradiol-and-igf-1-in-cardio-metabolic-diseases
#18
Milan Obradovic, Julijana Stanimirovic, Anastasija Panic, Nikola Bogdanovic, Emina Sudar-Milovanovic, Desanka Cenic-Milosevic, Esma R Isenovic
BACKGROUND: The sodium/potassium- adenosine- triphosphatase (Na+/K+-ATPase) is an important mediator in vasculature tone and contractility, and its abnormal regulation has been implicated in many diseases such as obesity, insulin resistance, diabetes, and hypertension. Decreased Na+/K+-ATPase abundance and its altered isoform expression induce cardiomyocytes death and cardiac dysfunction, possibly leading to the development of myocardial dilation and heart failure. Therefore, the regulation of Na+/K+-ATPase activity/expression could be important in treatment and possible prevention of cardio-metabolic diseases...
February 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28164075/the-impact-of-obesity-on-hyperandrogenemia-in-korean-girls
#19
Min Jae Kang, Seung Yang, Il Tae Hwang
PURPOSE: As metabolic complication and polycystic ovarian syndrome due to childhood obesity is rising, the role of hyperandrogenemia (HA) and hyperinsulinism is receiving attention. The aims of this study were to investigate the presence of obvious HA according to pubertal status and to find potential etiologic determinants of HA in Korean obese (OB) girls. METHODS: We analyzed 91 girls aged 6-17 years (prepuberty, n=54; puberty, n=37). Each girl was classified as being either normal weight (NW) or OB...
December 2016: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28164072/leptin-and-adiponectin-levels-in-girls-with-central-precocious-puberty-before-and-during-gnrh-agonist-treatment
#20
Jae Won Yoo, Chun Woo Song, Han Hyuk Lim
PURPOSE: The effects of gonadotropin-releasing hormone agonist (GnRHa) treatment on the energy metabolism in girls with central precocious puberty (CPP) are controversial. We focused the changes and related factors of serum levels of leptin and adiponectin in girls with CPP before and during GnRHa treatment. METHODS: Thirty girls with idiopathic CPP were enrolled in the study. Their auxological data and fasting blood were collected at the baseline and after six months of GnRHa treatment...
December 2016: Annals of Pediatric Endocrinology & Metabolism
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