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https://www.readbyqxmd.com/read/28342715/prediction-of-neonatal-respiratory-morbidity-by-quantitative-ultrasound-lung-texture-analysis-a-multicenter-study
#1
Montse Palacio, Elisenda Bonet-Carne, Teresa Cobo, Alvaro Perez-Moreno, Joan Sabrià, Jute Richter, Marian Kacerovsky, Bo Jacobsson, Raúl A García-Posada, Fernando Bugatto, Ramon Santisteve, Àngels Vives, Mauro Parra-Cordero, Edgar Hernandez-Andrade, José Luis Bartha, Pilar Carretero-Lucena, Kai Lit Tan, Rogelio Cruz-Martínez, Minke Burke, Suseela Vavilala, Igor Iruretagoyena, Juan Luis Delgado, Mauro Schenone, Josep Vilanova, Francesc Botet, George Sh Yeo, Jon Hyett, Jan Deprest, Roberto Romero, Eduard Gratacos
BACKGROUND: Prediction of neonatal respiratory morbidity may be useful to plan delivery in complicated pregnancies. The limited predictive performance of the current diagnostic tests together with the risks of an invasive procedure, limit the use of fetal lung maturity assessment. OBJECTIVE: To evaluate the performance of quantitative ultrasound texture analysis (quantusFLM®) to predict neonatal respiratory morbidity in preterm and early-term (<39.0 weeks) deliveries ...
March 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28335910/management-strategies-for-cln2-disease
#2
REVIEW
Ruth E Williams, Heather R Adams, Martin Blohm, Jessica L Cohen-Pfeffer, Emily de Los Reyes, Jonas Denecke, Kristen Drago, Charlie Fairhurst, Margie Frazier, Norberto Guelbert, Szilárd Kiss, Annamaria Kofler, John A Lawson, Lenora Lehwald, Mary-Anne Leung, Svetlana Mikhaylova, Jonathan W Mink, Miriam Nickel, Renée Shediac, Katherine Sims, Nicola Specchio, Meral Topcu, Ina von Löbbecke, Andrea West, Boris Zernikow, Angela Schulz
CLN2 disease (neuronal ceroid lipofuscinosis type 2) is a rare, autosomal recessive, pediatric-onset, rapidly progressive neurodegenerative lysosomal storage disorder caused by tripeptidyl peptidase 1 (TPP1) enzyme deficiency, and is characterized by language delay, seizures, rapid cognitive and motor decline, blindness, and early death. No management guidelines exist and there is a paucity of published disease-specific evidence to inform clinical practice, which currently draws upon experience from the field of childhood neurodisability...
April 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28314815/the-phosphorylation-state-of-the-drosophila-trp-channel-modulates-the-frequency-response-to-oscillating-light-in-vivo
#3
Olaf Voolstra, Elisheva Rhodes-Mordov, Ben Katz, Jonas-Peter Bartels, Claudia Oberegelsbacher, Susanne Katharina Schotthöfer, Bushra Yasin, Hanan Tzadok, Armin Huber, Baruch Minke
Drosophila photoreceptors respond to oscillating light of high frequency (∼100 Hz), while the detected maximal frequency is modulated by the light rearing conditions, thus maintaining high sensitivity to light and high temporal resolution. However, the molecular basis for this adaptive process is unclear. Here, we report that dephosphorylation of the light-activated Transient Receptor Potential (TRP) ion channel at S936 is a fast, graded, light-, and Ca(2+)-dependent process that is partially modulated by the rhodopsin phosphatase Retinal Degeneration C (RDGC)...
March 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28306738/comparative-evaluation-of-the-minimally-invasive-karyotyping-mink-algorithm-for-non-invasive-prenatal-testing
#4
Tianjiao Chu, Patricia A Shaw, Suveyda Yeniterzi, Mary Dunkel, Aleksander Rajkovic, W Allen Hogge, Kimberly D Bunce, David G Peters
Minimally Invasive Karyotyping (MINK) was communicated in 2009 as a novel method for the non-invasive detection of fetal copy number anomalies in maternal plasma DNA. The original manuscript illustrated the potential of MINK using a model system in which fragmented genomic DNA obtained from a trisomy 21 male individual was mixed with that of his karyotypically normal mother at dilutions representing fetal fractions found in maternal plasma. Although it has been previously shown that MINK is able to non-invasively detect fetal microdeletions, its utility for aneuploidy detection in maternal plasma has not previously been demonstrated...
2017: PloS One
https://www.readbyqxmd.com/read/28302328/experimental-pseudomonas-aeruginosa-mediated-rhino-sinusitis-in-mink
#5
S Kirkeby, A S Hammer, N Høiby, C M Salomonsen
OBJECTIVES: The nasal and sinus cavities in children may serve as reservoirs for microorganisms that cause recurrent and chronic lung infections. This study evaluates whether the mink can be used as an animal model for studying Pseudomonas aeruginosa mediated rhino-sinusitis since there is no suitable traditional animal model for this disease. METHODS: Nasal tissue samples from infected and control mink were fixed in formalin, demineralized, and embedded in paraffin...
December 27, 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28301147/exposure-to-persistent-organic-pollutants-reduces-testosterone-concentrations-and-affects-sperm-viability-and-morphology-during-the-mating-peak-period-in-a-controlled-experiment-on-farmed-arctic-foxes-vulpes-lagopus
#6
Christian Sonne, Peter A Torjesen, Eva Fuglei, Derek C G Muir, Bjorn M Jenssen, Even Jørgensen, Rune Dietz, Øystein Ahlstrøm
We investigated testosterone production and semen parameters in farmed Arctic foxes by dietary exposure to persistent organic pollutants (POPs) for 22 months. Eight male foxes were given a diet of POP-contaminated minke whale blubber whereas their eight male siblings were fed a control diet containing pig fat as main fat source. The minke whale-based feed contained a ∑POPs concentration of 802 ng/g ww whereas the pig-based feed contained ∑POPs of 24 ng/g ww. At the end of the experiment, ∑POP concentrations in adipose tissue were 8856±2535 ng/g ww in the exposed foxes and 1264±539 ng/g ww in the control foxes...
March 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28298549/diverging-white-matter-trajectories-in-children-after-traumatic-brain-injury-the-rapbi-study
#7
Emily L Dennis, Faisal Rashid, Monica U Ellis, Talin Babikian, Roza M Vlasova, Julio E Villalon-Reina, Yan Jin, Alexander Olsen, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Paul M Thompson, Robert F Asarnow
OBJECTIVE: To examine longitudinal trajectories of white matter organization in pediatric moderate/severe traumatic brain injury (msTBI) over a 12-month period. METHODS: We studied 21 children (16 M/5 F) with msTBI, assessed 2-5 months postinjury and again 13-19 months postinjury, as well as 20 well-matched healthy control children. We assessed corpus callosum function through interhemispheric transfer time (IHTT), measured using event-related potentials, and related this to diffusion-weighted MRI measures of white matter (WM) microstructure...
March 15, 2017: Neurology
https://www.readbyqxmd.com/read/28295659/genetic-parameters-for-fur-quality-graded-on-live-animals-and-dried-pelts-of-american-mink-neovison-vison
#8
J P Thirstrup, J Jensen, M S Lund
Fur quality and skin size are integral qualities in the mink industry and are main determinants of sales price and subsequent income for mink fur producers. Parental animals of future generations are selected based on quality grading from live animals, but selection response is obtained from dried skins sold after pelting. In this study, we evaluated traits assessed during live grading and pelt traits examined on dried skins to determine correlation between live and pelt traits. Grading traits and body weight were measured during live animal grading for 9,539 Brown American mink, and pelt quality traits and skin size were evaluated on 8,385 dried mink skins after pelting...
March 10, 2017: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/28284614/characterization-of-h5n1-highly-pathogenic-mink-influenza-viruses-in-eastern-china
#9
Wenming Jiang, Suchun Wang, Chuanmei Zhang, Jinping Li, Guangyu Hou, Cheng Peng, Jiming Chen, Hu Shan
Members of the H5 subtype of highly pathogenic avian influenza viruses pose a great threat to both poultry and humans with severe consequences for both industry and public health sectors. Here, we isolated and characterized two H5N1 highly pathogenic influenza viruses in deceased mink from eastern China. Phylogenetic analyses showed that the G15 and XB15 viruses belonged to clade 2.3.2.1b and 2.3.2.1e, respectively. Both of these viruses were highly pathogenic in chickens. They were also shown to exhibit moderate to high pathogenicity in mice without pre-adaptation...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28283342/long-term-follow-up-study-of-patients-with-a-unilateral-complete-cleft-of-lip-alveolus-and-palate-following-the-utrecht-treatment-protocol-dental-arch-relationships
#10
Isabelle Francisca Petronella Maria Kappen, Gerhard Koendert Pieter Bittermann, Dirk Bitterman, Aebele Barber Mink van der Molen, William Shaw, Corstiaan Cornelis Breugem
OBJECTIVE: This study sought to evaluate long-term dental arch relationships in adults with a unilateral complete cleft lip and palate (UCLP) treated by the Utrecht protocol and to compare results with the centers from the Eurocleft study. MATERIALS AND METHODS: Retrospective analysis of UCLP patients age 17 or older, treated by two-stage palate closure at the Wilhelmina Children's Hospital, a tertiary center for cleft surgery in Utrecht, the Netherlands. Patients were invited to the clinic for a long-term evaluation...
February 6, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28281362/defining-leadership-competencies-for-pediatric-critical-care-fellows-results-of-a-national-needs-assessment
#11
Michael L Green, Margaret Winkler, Richard Mink, Melissa L Brannen, Meredith Bone, Tensing Maa, Grace M Arteaga, Megan E McCabe, Karen Marcdante, James Schneider, David A Turner
INTRODUCTION: Physicians in training, including those in Pediatric Critical Care Medicine, must develop clinical leadership skills in preparation to lead multidisciplinary teams during their careers. This study seeks to identify multidisciplinary perceptions of leadership skills important for Pediatric Critical Care Medicine fellows to attain prior to fellowship completion. METHODS: We performed a multi-institutional survey of Pediatric Critical Care Medicine attendings, fellows, and nurses...
March 10, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28280544/the-influence-of-sea-ice-wind-speed-and-marine-mammals-on-southern-ocean-ambient-sound
#12
Sebastian Menze, Daniel P Zitterbart, Ilse van Opzeeland, Olaf Boebel
This paper describes the natural variability of ambient sound in the Southern Ocean, an acoustically pristine marine mammal habitat. Over a 3-year period, two autonomous recorders were moored along the Greenwich meridian to collect underwater passive acoustic data. Ambient sound levels were strongly affected by the annual variation of the sea-ice cover, which decouples local wind speed and sound levels during austral winter. With increasing sea-ice concentration, area and thickness, sound levels decreased while the contribution of distant sources increased...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28275650/optimizing-image-registration-and-infarct-definition-in-stroke-research
#13
George W J Harston, David Minks, Fintan Sheerin, Stephen J Payne, Michael Chappell, Peter Jezzard, Mark Jenkinson, James Kennedy
OBJECTIVE: Accurate representation of final infarct volume is essential for assessing the efficacy of stroke interventions in imaging-based studies. This study defines the impact of image registration methods used at different timepoints following stroke, and the implications for infarct definition in stroke research. METHODS: Patients presenting with acute ischemic stroke were imaged serially using magnetic resonance imaging. Infarct volume was defined manually using four metrics: 24-h b1000 imaging; 1-week and 1-month T2-weighted FLAIR; and automatically using predefined thresholds of ADC at 24 h...
March 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28254245/design-of-a-multisite-study-assessing-the-impact-of-tic-disorders-on-individuals-families-and-communities
#14
E F Augustine, H R Adams, R H Bitsko, E van Wijngaarden, A H Claussen, A Thatcher, C E Hanks, A B Lewin, T G O'Connor, A Vierhile, M L Danielson, R Kurlan, T K Murphy, J W Mink
BACKGROUND: Tic disorders, including Tourette syndrome, are complex, multisymptom diseases, yet the impact of these disorders on affected children, families, and communities is not well understood. METHODS: To improve the understanding of the impacts of Tourette syndrome, two research groups conducted independent cross-sectional studies using qualitative and quantitative measures. They focused on similar themes, but distinct scientific objectives, and the sites collaborated to align methods of independent research proposals with the aim of increasing the analyzable sample size...
March 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28249174/reduced-severity-of-histopathological-lesions-in-mink-selected-for-tolerance-to-aleutian-mink-disease-virus-infection
#15
A Hossain Farid, Linda E Ferns
The objective of this study was to measure the effect of selection for tolerance on the severity of the Aleutian disease (AD) lesions in mink. Sensitivity and specificity of antibody detection in the blood by counter-immunoelectrophoresis (CIEP) relative to the presence of Aleutian mink disease virus (AMDV) in the spleen by PCR in naturally infected farmed mink were also estimated. Carcasses of 680 sero-positive (CIEP-P) black mink from 28 farms in Nova Scotia, Canada, and from 132 sero-negative (CIEP-N) mink from 14 of these farms were collected at pelting time...
February 16, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28231262/oleanolic-acid-induces-migration-in-mv1lu-and-mda-mb-231-epithelial-cells-involving-egf-receptor-and-map-kinases-activation
#16
Ángel Bernabé-García, David Armero-Barranco, Sergio Liarte, María Ruzafa-Martínez, Antonio Jesús Ramos-Morcillo, Francisco José Nicolás
During wound healing, skin function is restored by the action of several cell types that undergo differentiation, migration, proliferation and/or apoptosis. These dynamics are tightly regulated by the evolution of the extra cellular matrix (ECM) contents along the process. Pharmacologically active flavonoids have shown to exhibit useful physiological properties interesting in pathological states. Among them, oleanolic acid (OA), a pentacyclic triterpene, shows promising properties over wound healing, as increased cell migration in vitro and improved wound resolution in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28225797/use-of-bovine-recombinant-prion-protein-and-real-time-quaking-induced-conversion-to-detect-cattle-transmissible-mink-encephalopathy-prions-and-discriminate-classical-and-atypical-l-and-h-type-bovine-spongiform-encephalopathy
#17
Soyoun Hwang, Justin J Greenlee, Eric M Nicholson
Prions are amyloid-forming proteins that cause transmissible spongiform encephalopathies through a process involving conversion from the normal cellular prion protein to the pathogenic misfolded conformation (PrPSc). This conversion has been used for in vitro assays including serial protein misfolding amplification and real-time quaking induced conversion (RT-QuIC). RT-QuIC can be used for the detection of prions in a variety of biological tissues from humans and animals. Extensive work has been done to demonstrate that RT-QuIC is a rapid, specific, and highly sensitive prion detection assay...
2017: PloS One
https://www.readbyqxmd.com/read/28224658/predictive-meta-regressions-relating-mercury-tissue-concentrations-of-freshwater-piscivorous-mammals
#18
Kristin M Eccles, Philippe J Thomas, Hing Man Chan
Mercury (Hg) is a pollutant of global concern. Sentinel species such as river otter (Lontra canadensis) and mink (Neovison vison) are often used to monitor environmental concentrations in freshwater ecosystems. Tissue total Hg (THg) concentrations are frequently used as biomarkers of exposure. However, there is no comprehensive model relating Hg tissue concentrations in different tissues, making interstudy comparisons challenging. Our objective was to establish conversion factors relating fur, brain, liver, kidney, and muscle THg concentrations using mean concentrations and standard errors reported in the literature...
February 22, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28215201/early-kit-mortality-and-growth-in-farmed-mink-are-affected-by-litter-size-rather-than-nest-climate
#19
T M Schou, J Malmkvist
We investigated the effects of nest box climate on early mink kit mortality and growth. We hypothesised that litters in warm nest boxes experience less hypothermia-induced mortality and higher growth rates during the 1st week of life. This study included data from 749, 1-year-old breeding dams with access to nesting materials. Kits were weighed on days 1 and 7, dead kits were collected daily from birth until day 7 after birth, and nest climate was measured continuously from days 1 to 6. We tested the influences of the following daily temperature (T) and humidity (H) parameters on the number of live-born kit deaths and kit growth: T mean, T min, T max, T var (fluctuation) and H mean...
February 20, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28188722/prevalence-of-hypokalemia-before-and-after-bowel-preparation-for-colonoscopy-in-high-risk-patients
#20
Ankie Reumkens, Ad A M Masclee, Bjorn Winkens, Cees T van Deursen, Silvia Sanduleanu, C Minke Bakker
BACKGROUND AND AIMS: Bowel preparation for colonoscopy should not cause significant shifts in systemic electrolyte concentrations. We recently encountered 2 cases of severe postcolonoscopy hypokalemia with fatal consequences, prompting us to conduct a study to explore the magnitude of and risk factors for hypokalemia associated with bowel preparation. We paid specific attention to higher risk subgroups, in particular diuretic users, hospitalized patients and patients estimated at to be high risk by the gastroenterologist...
February 7, 2017: Gastrointestinal Endoscopy
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