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https://www.readbyqxmd.com/read/28532807/distribution-of-aleutian-mink-disease-virus-contamination-in-the-environment-of-infected-mink-farms
#1
A Prieto, R Fernández-Antonio, J M Díaz-Cao, G López, P Díaz, J M Alonso, P Morrondo, G Fernández
Control and eradication of Aleutian Mink Disease Virus (AMDV) are a major concern for fur-bearing animal production. Despite notably reducing disease prevalence, current control programs are unable to prevent the reinfection of farms, and environmental AMDV persistence seems to play a major role regarding this issue. In this study 114 samples from different areas and elements of seven infected mink farms were analyzed by qPCR in order to evaluate the environmental distribution of AMDV load. Samples were classified into nine categories, depending on the type of sample and degree of proximity to the animals, the main source of infection...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28532438/the-effect-of-color-type-on-early-wound-healing-in-farmed-mink-neovison-vison
#2
A Jespersen, H E Jensen, J F Agger, P M H Heegaard, P Damborg, B Aalbæk, A S Hammer
BACKGROUND: Individual differences of mink, including color type, are speculated to affect the course of wound healing, thereby impacting wound assessment and management on the farms, as well as the assessment of wounds in forensic cases. In this study, we examined the effect of color type on early wound healing in farmed mink. Full thickness excisional wounds (2 × 2 cm) were made on the back in 18 mink of the color types Brown, Silverblue and Blue Iris. Gross and microscopic pathology of the wounds was evaluated 2 days post-wounding together with degree of wound size reduction, presence of bacteria and blood analyses...
May 22, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28507895/diverging-volumetric-trajectories-following-pediatric-traumatic-brain-injury
#3
Emily L Dennis, Joshua Faskowitz, Faisal Rashid, Talin Babikian, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Neda Jahanshad, Paul M Thompson, Robert F Asarnow
Traumatic brain injury (TBI) is a significant public health concern, and can be especially disruptive in children, derailing on-going neuronal maturation in periods critical for cognitive development. There is considerable heterogeneity in post-injury outcomes, only partially explained by injury severity. Understanding the time course of recovery, and what factors may delay or promote recovery, will aid clinicians in decision-making and provide avenues for future mechanism-based therapeutics. We examined regional changes in brain volume in a pediatric/adolescent moderate-severe TBI (msTBI) cohort, assessed at two time points...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28503899/effects-of-maternal-treatment-with-%C3%AE-hydroxy-%C3%AE-metylbutyrate-and-2-oxoglutaric-acid-on-femur-development-in-offspring-of-minks-of-the-standard-dark-brown-type
#4
E Tomaszewska, P Dobrowolski, I Świetlicka, S Muszyński, K Kostro, A Jakubczak, I Taszkun, A Żmuda, K Rycerz, T Blicharski, J Jaworska-Adamu
The aim of the study was to evaluate the effect of the diet, mother type and sex of the offspring on the mechanical and geometric parameters of long bones as well as bone tissue density in minks. Primiparous and multiparous dams were supplemented with β-hydroxy β-methylbutyrate (a metabolite of leucine, at the daily dosage of 0.02 g/kg of body weight) and/or 2-oxoglutaric acid (a precursor of glutamine, at the daily dosage of 0.4 g/kg of body weight) during gestation. The diet did not influence bone tissue density and the length of the humerus...
May 15, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28501627/detection-of-viromes-of-rna-viruses-using-the-next-generation-sequencing-libraries-prepared-by-three-methods
#5
Yuan Qiu, Ji-Ming Chen, Tong Wang, Guang-Yu Hou, Qing-Ye Zhuang, Run Wu, Kai-Cheng Wang
Virome (viral megagenomics) detection using next generation sequencing has been widely applied in virology, but its methods remain complicated and need optimization. In this study, we detected the viromes of RNA viruses of one mock sample, one pooled duck feces sample and one pooled mink feces sample on the Personal Genome Machine platform using the sequencing libraries prepared by three methods. The sequencing primers were added through random hybridization and ligation to fragmented viral RNA using a RNA-Seq kit in method 1, through random reverse transcription (RT) and polymerase chain reaction (PCR) in method 2 which was developed in our laboratory, and through hybridization and ligation to fragmented amplicons of random RT-PCR using a single primer in method 3...
May 10, 2017: Virus Research
https://www.readbyqxmd.com/read/28487558/full-genetic-characterization-and-epidemiology-of-a-novel-amdoparvovirus-in-striped-skunk-mephitis-mephitis
#6
Marta Canuti, Hillary E Doyle, Ann P Britton, Andrew S Lang
Amdoparvovirus is a newly defined parvoviral genus that contains four species (Carnivore amdoparvovirus 1-4), including the well-known Aleutian mink disease virus (AMDV). Amdoparvoviruses cause an immune-associated and often lethal wasting syndrome in Mustelidae and Caninae hosts. In this study, we molecularly investigated amdoparvoviruses detected in 44 striped skunks (Mephitis mephitis) found dead in and around Vancouver, British Columbia, Canada. Some of the animals exhibited pathological changes compatible with amdoparvovirus-associated disease...
May 10, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28482327/first-description-of-cryptosporidium-ubiquitum-xiia-subtype-family-in-farmed-fur-animals
#7
Klára Kellnerová, Nikola Holubová, Anna Jandová, Antonín Vejčík, John McEvoy, Bohumil Sak, Martin Kváč
This study investigated the prevalence of Cryptosporidium in farmed fur animals in the Czech Republic and Poland. A total of 480 faecal samples were collected from fur animals, including 300 American mink (Mustela vison), 60 silver foxes (Vulpes vulpes), 50 long-tailed chinchillas (Chinchilla lanigera), and 70 nutrias (Myocastor coypus), at 14 farms. Samples were examined for the presence of Cryptosporidium using microscopy (following aniline-carbol-methyl violet staining) and sequence analysis of PCR amplified products...
April 19, 2017: European Journal of Protistology
https://www.readbyqxmd.com/read/28475316/pentafluorosulfanyl-substituted-benzopyran-analogues-as-new-cyclooxygenase-2-inhibitors-with-excellent-pharmacokinetics-and-efficacy-in-blocking-inflammation
#8
Yanmei Zhang, Yican Wang, Chuang He, Xiaorong Liu, Yongzhi Lu, Tingting Chen, Qiong Pan, Jingfang Xiong, Miaoqin She, Zhengchao Tu, Xiaochu Qin, Minke Li, Micky D Tortorella, John J Talley
In this report, we disclose the design and synthesis of a series of pentafluorosulfanyl (SF5) benzopyran derivatives as novel COX-2 inhibitors with improved pharmacokinetic and pharmacodynamic properties. The pentafluorosulfanyl compounds showed both potency and selectivity for COX-2 and demonstrated efficacy in several murine models of inflammation and pain. More interestingly, one of the compounds, R,S-3a, revealed exceptional efficacy in the adjuvant induced arthritis (AIA) model, achieving an ED50 as low as 0...
May 5, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28460751/a-retrospective-cohort-study-estimating-the-individual-aleutian-disease-progress-in-female-mink-using-a-vp2-elisa-and-its-association-to-reproductive-performance
#9
Anna-Maria Andersson, Ann-Kristin Nyman, Per Wallgren
Aleutian Disease (AD) is an important disease in mink characterized by a persistent chronic infection typically causing a progressive disease with symptoms such as weight loss, polydipsia, polyuria, reduced reproductive performance and increased herd mortality. Due to lack of success in eradicating AD by stamping out, disease control programs based on estimating the disease progression have been implemented and used in the selection of future breeding animals. The aim of this project was to evaluate the association between the reproductive performance of female mink (expressed as being barren or not and litter size of non-barren females) and the individual AD status (defined as diseased or non-diseased based on the OD450 value in a dried blood spot samples (DBS) VP2 ELISA) while controlling for age and color type...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28440399/%C3%AE-1-antitrypsin-promotes-lung-adenocarcinoma-metastasis-through-upregulating-fibronectin-expression
#10
Yan Li, Liyun Miao, Min Yu, Minke Shi, Yongsheng Wang, Jun Yang, Yonglong Xiao, Hourong Cai
α1-antitrypsin (AAT) has been recognized to be associated with lung adenocarcinoma metastasis. However, the mechanisms by which AAT promotes tumor metastasis remain to be investigated. Herein, we first examined AAT expression in a panel of formalin-fixed paraffin-embedded tumor tissues from 88 lung adenocarcinoma patients undergoing curative resection, using immunohistochemical methods. Lung adenocarcinoma patients with high AAT expression showed a significantly shorter overall survival compared to those with low AAT expression by Kaplan-Meier method (P=0...
April 18, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28437587/relationship-type-affects-the-reliability-of-dispersal-distance-estimated-using-pedigree-inferences-in-partially-sampled-populations-a-case-study-involving-invasive-american-mink-in-scotland
#11
Y Melero, M K Oliver, X Lambin
Estimating dispersal-a key parameter for population ecology and management-is notoriously difficult. The use of pedigree assignments, aided by likelihood-based software, has become popular to estimate dispersal rate and distance. However, the partial sampling of populations may produce false assignments. Further, it is unknown how the accuracy of assignment is affected by the genealogical relationships of individuals and is reflected by software-derived assignment probabilities. Inspired by a project managing invasive American mink (Neovison vison), we estimated individual dispersal distances using inferred pairwise relationships of culled individuals...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28437554/molecular-identification-of-cetaceans-from-the-west-atlantic-using-the-e3-i5-region-of-coi
#12
L H O Falcão, A S Campos, J E P Freitas, M A A Furtado-Neto, V V Faria
Molecular identification is very useful in cases where morphology-based species identification is not possible. Examples for its application in cetaceans include the identification of carcasses of stranded animals in advanced state of decomposition and body parts that are illegally traded. One DNA region that is often used for molecular identification is the Folmer region of the mitochondrial gene cytochrome c oxidase subunit I (COI) (locus 48 to 705 bp). This locus has been used for the identification of several animal species, including whales and dolphins...
April 20, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28421030/cluster-analysis-to-identify-possible-subgroups-in-tinnitus-patients
#13
Minke J C van den Berge, Rolien H Free, Rosemarie Arnold, Emile de Kleine, Rutger Hofman, J Marc C van Dijk, Pim van Dijk
INTRODUCTION: In tinnitus treatment, there is a tendency to shift from a "one size fits all" to a more individual, patient-tailored approach. Insight in the heterogeneity of the tinnitus spectrum might improve the management of tinnitus patients in terms of choice of treatment and identification of patients with severe mental distress. The goal of this study was to identify subgroups in a large group of tinnitus patients. METHODS: Data were collected from patients with severe tinnitus complaints visiting our tertiary referral tinnitus care group at the University Medical Center Groningen...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28419962/temporal-trends-of-pbdes-and-emerging-flame-retardants-in-belugas-from-the-st-lawrence-estuary-canada-and-comparisons-with-minke-whales-and-canadian-arctic-belugas
#14
Antoine E Simond, Magali Houde, Véronique Lesage, Jonathan Verreault
An exponential level increase of the ubiquitous halogenated flame retardant (HFR) class polybrominated diphenyl ether (PBDE) has been documented during the 1990s in endangered belugas (Delphinapterus leucas) from the St. Lawrence Estuary (SLE), Eastern Canada. The recent worldwide bans and regulations of PBDE mixtures led to their replacement by alternative HFRs (so-called emerging HFRs) that are increasingly being reported in various environmental compartments. There are, however, limited knowledge on the spatial and temporal trends of PBDEs and emerging HFRs in cetaceans, especially after restrictions on PBDE usage...
April 15, 2017: Environmental Research
https://www.readbyqxmd.com/read/28418765/brucella-ceti-infection-in-a-common-minke-whale-balaenoptera-acutorostrata-with-associated-pathology
#15
Nicholas J Davison, Lorraine L Perrett, Claire Dawson, Mark P Dagleish, Gary Haskins, Jakub Muchowski, Adrian M Whatmore
There are three major lineages of marine mammal strains of Brucella spp.: Brucella ceti ST23, found predominantly in porpoises; B. ceti ST26, in pelagic delphinids and ziphiids; and Brucella pinnipedialis ST24/25, predominantly in seals. The isolation of Brucella spp. in mysticetes has been described only in common minke whales ( Balaenoptera acutorostrata ) in Norway and Scotland. We report a third case of Brucella infection and isolation in a minke whale associated with a large abscess. In contrast to the two previous reports that involved isolates of B...
April 18, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28412080/reproductive-parameters-of-critically-endangered-european-mink-mustela-lutreola-in-captivity
#16
Kairi Kiik, Tiit Maran, Kristel Nemvalts, Siiri-Lii Sandre, Toomas Tammaru
Founding captive populations is often the last chance for saving endangered species from extinction. Ensuring successful reproduction is typically most critical for the maintenance of captive populations, with purposeful selection of individuals for breeding being one of the crucial aspects. Comparable cross-species data on the determinants of reproduction success are most useful for solving problems in captive species programs. In the present study, we provide an overview of a 20-year captive breeding program of the critically endangered European mink...
March 31, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28405395/pulse-of-inflammatory-proteins-in-the-pregnant-uterus-of-european-polecats-mustela-putorius-leading-to-the-time-of-implantation
#17
Heli Lindeberg, Richard J S Burchmore, Malcolm W Kennedy
Uterine secretory proteins protect the uterus and conceptuses against infection, facilitate implantation, control cellular damage resulting from implantation, and supply pre-implantation embryos with nutrients. Unlike in humans, the early conceptus of the European polecat (Mustela putorius; ferret) grows and develops free in the uterus until implanting at about 12 days after mating. We found that the proteins appearing in polecat uteri changed dramatically with time leading to implantation. Several of these proteins have also been found in pregnant uteri of other eutherian mammals...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28389968/predictors-of-left-ventricular-remodeling-after-st-elevation-myocardial-infarction
#18
Tom Hendriks, Minke H T Hartman, Pieter J J Vlaar, Niek H J Prakken, Yldau M Y van der Ende, Chris P H Lexis, Dirk J van Veldhuisen, Iwan C C van der Horst, Erik Lipsic, Robin Nijveldt, Pim van der Harst
Adverse left ventricular (LV) remodeling after acute ST-elevation myocardial infarction (STEMI) is associated with morbidity and mortality. We studied clinical, biochemical and angiographic determinants of LV end diastolic volume index (LVEDVi), end systolic volume index (LVESVi) and mass index (LVMi) as global LV remodeling parameters 4 months after STEMI, as well as end diastolic wall thickness (EDWT) and end systolic wall thickness (ESWT) of the non-infarcted myocardium, as compensatory remote LV remodeling parameters...
April 7, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28387336/using-energy-budgets-to-combine-ecology-and-toxicology-in-a-mammalian-sentinel-species
#19
Jean-Pierre W Desforges, Christian Sonne, Rune Dietz
Process-driven modelling approaches can resolve many of the shortcomings of traditional descriptive and non-mechanistic toxicology. We developed a simple dynamic energy budget (DEB) model for the mink (Mustela vison), a sentinel species in mammalian toxicology, which coupled animal physiology, ecology and toxicology, in order to mechanistically investigate the accumulation and adverse effects of lifelong dietary exposure to persistent environmental toxicants, most notably polychlorinated biphenyls (PCBs). Our novel mammalian DEB model accurately predicted, based on energy allocations to the interconnected metabolic processes of growth, development, maintenance and reproduction, lifelong patterns in mink growth, reproductive performance and dietary accumulation of PCBs as reported in the literature...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28379301/embryo-arrest-and-reactivation-potential-candidates-controlling-embryonic-diapause-in-the-tammar-wallaby-and-mink%C3%A2
#20
Jane C Fenelon, Geoffrey Shaw, Stephen R Frankenberg, Bruce D Murphy, Marilyn B Renfree
Embryonic diapause is a period of developmental arrest which requires coordination of a molecular cross-talk between the endometrium and blastocyst to ensure a successful reactivation, but the exact mechanisms are undefined. The objectives of this study were to screen the tammar blastocyst for potential diapause control factors and to investigate the potential for members of the epidermal growth factor (EGF) family to coordinate reactivation. A select number of factors were also examined in the mink to determine whether their expression patterns were conserved across diapause species...
April 1, 2017: Biology of Reproduction
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