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https://www.readbyqxmd.com/read/27936014/inhibition-of-interleukin-6-receptor-in-a-murine-model-of-myocardial-ischemia-reperfusion
#1
Minke H T Hartman, Inge Vreeswijk-Baudoin, Hilde E Groot, Kees W A van de Kolk, Rudolf A de Boer, Irene Mateo Leach, Rozemarijn Vliegenthart, Herman H W Sillje, Pim van der Harst
BACKGROUND: Interleukin-6 (IL-6) levels are upregulated in myocardial infarction. Recent data suggest a causal role of the IL-6 receptor (IL-6R) in coronary heart disease. We evaluated if IL-6R blockade by a monoclonal antibody (MR16-1) prevents the heart from adverse left ventricular remodeling in a mouse model of ischemia-reperfusion (I/R). METHODS: CJ57/BL6 mice underwent I/R injury (left coronary artery ligation for 45 minutes) or sham surgery, and thereafter received MR16-1 (2mg/mouse) 5 minutes before reperfusion and 0...
2016: PloS One
https://www.readbyqxmd.com/read/27928914/high-molecular-polymorphism-of-the-hypervariable-region-in-the-vp2-gene-of-aleutian-mink-disease-virus
#2
A Jakubczak, M Kowalczyk, K Kostro, B Horecka, G Jezewska-Witkowska
Parvoviruses exhibit extreme genetic plasticity. The VP2 protein, containing a hypervariable region, is of particular importance. A single nucleotide change in this part of the genome and its effect on the amino acid sequence may significantly affect the range of infected hosts, tropism for specific tissues, or virulence. The high polymorphism in the hypervariable region can be exploited for phylogenetic analysis. The aim of this study was to analyze the polymorphism of the VP2 hypervariable region in isolates of the Aleutian mink disease virus (AMDV) infecting Polish mink farms and to determine the phylogenetic relationships between the Polish isolates and genetic variants of the pathogen occurring in other countries...
2016: Acta Virologica
https://www.readbyqxmd.com/read/27921267/independence-of-long-term-contextual-memory-and-short-term-perceptual-hypotheses-evidence-from-contextual-cueing-of-interrupted-search
#3
Bernhard Schlagbauer, Maurice Mink, Hermann J Müller, Thomas Geyer
Observers are able to resume an interrupted search trial faster relative to responding to a new, unseen display. This finding of rapid resumption is attributed to short-term perceptual hypotheses generated on the current look and confirmed upon subsequent looks at the same display. It has been suggested that the contents of perceptual hypotheses are similar to those of other forms of memory acquired long-term through repeated exposure to the same search displays over the course of several trials, that is, the memory supporting "contextual cueing...
December 5, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27918148/influenza-a-virus-surveillance-in-the-invasive-american-mink-neovison-vison-from-freshwater-ecosystems-northern-spain
#4
H Gholipour, N Busquets, X Fernández-Aguilar, A Sánchez, M P Ribas, G De Pedro, P Lizarraga, O Alarcia-Alejos, C Temiño, O Cabezón
Influenza A viruses (IAVs) are negative-sense, single-stranded and segmented RNA viruses of the Orthomyxoviridae family that may cause acute respiratory disease in a wide range of birds and mammals. Susceptibility of several species within the family Mustelidae to IAVs has been reported as a result of natural or experimental infections. The objectives of this study were to assess whether free-ranging American mink populations from Northern Spain were infected with IAV and try to define the role of this species in the epidemiology of IAV...
December 5, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27917544/postvaccination-wounds-associated-predominantly-with-arcanobacterium-phocae-in-minks-neovison-vison-at-three-mink-farms
#5
Robert J Molenaar, Rianne Buter, Agnieszka Sroka
BACKGROUND: The emerging skin disease fur animal epidemic necrotic pyoderma (FENP) has been attributed to infection with Arcanobacterium phocae (ABP). The exact pathogenesis and risk factors of FENP have yet to be elucidated. ANIMALS: Three mink from each of three different mink farms (A-C) with postvaccination skin wounds at the vaccination site and six mink from an unaffected mink farm (D) that had used the same vaccine batch and vaccination site (hind leg). METHODS AND RESULTS: All minks from farms A-C had severe necrotizing to necropurulent dermatitis where they were vaccinated intramuscularly in the hind leg...
December 4, 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27916667/development-and-validation-of-an-immunohistochemistry-procedure-for-the-detection-of-a-neurotropic-bovine-astrovirus
#6
Céline L Boujon, Senija Selimovic-Hamza, Ilias Bouzalas, Torsten Seuberlich
Members of the Astroviridae family are best known to cause diarrhea in different mammalian species. Lately, some strains have been associated with encephalitis in humans, minks and cattle. In this study, we developed an immunohistochemistry (IHC) procedure for the detection of a neurotropic bovine astrovirus (BoAstV-CH13/NeuroS1), which is associated with non-suppurative encephalitis in cattle. We expressed five recombinant antigens corresponding to different putative viral proteins of BoAstV-CH13/NeuroS1. Antigens were then used for the production of hyperimmune sera in rabbits...
January 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/27914375/a-complex-baleen-whale-call-recorded-in-the-mariana-trench-marine-national-monument
#7
Sharon L Nieukirk, Selene Fregosi, David K Mellinger, Holger Klinck
In fall 2014 and spring 2015, passive acoustic data were collected via autonomous gliders east of Guam in an area that included the Mariana Trench Marine National Monument. A short (2-4 s), complex sound was recorded that features a ∼38 Hz moan with both harmonics and amplitude modulation, followed by broad-frequency metallic-sounding sweeps up to 7.5 kHz. This sound was recorded regularly during both fall and spring surveys. Aurally, the sound is quite unusual and most resembles the minke whale "Star Wars" call...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27911239/microvascular-decompression-of-the-cochleovestibular-nerve-for-treatment-of-tinnitus-and-vertigo-a-systematic-review-and-meta-analysis-of-individual-patient-data
#8
Minke J C van den Berge, J Marc C van Dijk, Iris A Posthumus, Nynke Smidt, Pim van Dijk, Rolien H Free
OBJECTIVE Microvascular decompression (MVD) is regarded as a valid treatment modality in neurovascular conflicts (NVCs) causing, for example, trigeminal neuralgia and hemifacial spasms. An NVC of the cochleovestibular nerve might cause tinnitus and/or vertigo; however, general acceptance of MVD for this indication is lacking. The aim of this study was to investigate the effectiveness, safety, and prognostic factors for success of MVD of the cochleovestibular nerve. METHODS A systematic review and meta-analysis of individual patient data (IPD) were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Individual Patient Data (PRISMA-IPD) guidelines...
December 2, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27906703/left-ventricular-ejection-fraction-and-mortality-in-patients-with-st-elevation-myocardial-infarction-and-bundle-branch-block
#9
M Yldau van der Ende, Minke H T Hartman, Tom Hendriks, Hindrik W van der Werf, Erik Lipsic, Pim van der Harst
BACKGROUND: The aim of our study is to assess the effect of bundle branch block (BBB) on mortality and left ventricular ejection fraction (LVEF) in ST-elevation myocardial infarction (STEMI) patients treated in the current era of percutaneous reperfusion therapy. PATIENTS AND METHODS: In this retrospective cohort study, a total of 1123 STEMI patients treated in the University Medical Center Groningen from January 2011 until May 2013 were included. The follow-up duration was 2-4 years...
November 30, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27898909/protein-and-amino-acid-bioavailability-of-extruded-dog-food-with-protein-meals-of-different-quality-using-growing-mink-as-a-model
#10
M T Tjernsbekk, A-H Tauson, C F Matthiesen, Ø Ahlstrøm
The present study evaluated growing mink () as a model for dietary protein quality assessment of protein meals used in extruded dog foods. Three foods with similar CP content but of different protein quality were produced using different protein meals. The protein meals varied with respect to CP digestibility and AA composition and included lamb meal (LBM), poultry meal (PM), and fish meal (FM) with low, intermediate, and high protein quality, respectively. Nitrogen balance, BW gain, protein efficiency ratio (PER), and apparent total tract digestibility (ATTD) were used as measures of protein and AA bioavailability in growing mink...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27897387/small-molecule-induced-and-cooperative-enzyme-assembly-on-a-14-3-3-scaffold
#11
Anniek den Hamer, Lenne Lemmens, Minke Nijenhuis, Christian Ottmann, Maarten Merkx, Tom de Greef, Luc Brunsveld
Scaffold proteins regulate cell signaling by promoting the proximity of putative interaction partners. While frequently applied in a cellular setting, their fundamental understanding, amongst other in terms of quantitative parameters, has been lagging behind. Here we present a scaffold protein platform based on the native 14-3-3 dimeric protein and under the control of a small-molecule, which allows to be studied in an in vitro setting and mathematically described. Robust small-molecule regulation of caspase-9 activity via induced dimerization on the 14-3-3 scaffold was demonstrated...
November 29, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27885561/outbreak-of-severe-pseudorabies-virus-infection-in-pig-offal-fed-farmed-mink-in-liaoning-province-china
#12
Hao Liu, Xin-Tong Li, Bo Hu, Xiao-Yu Deng, Lei Zhang, Shi-Zhen Lian, Hai-Ling Zhang, Shuang Lv, Xiang-Hong Xue, Rong-Guang Lu, Ning Shi, Ming-Hao Yan, Peng-Peng Xiao, Xi-Jun Yan
An outbreak of severe pseudorabies virus (PRV) infection in farmed mink occurred in northern China in late 2014, causing significant economic losses in the local fur industry. Here, we report the first case of a PRV outbreak in mink in northeastern China, caused by feeding farmed mink with raw pork or organs contaminated by PRV. Mink infected with virulent PRV exhibited diarrhea, neurologic signs, and higher mortality, which can be misdiagnosed as highly pathogenic mink enteritis virus (MEV), canine distemper virus (CDV), and food poisoning...
November 24, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27875724/the-lifelines-cohort-study-prevalence-and-treatment-of-cardiovascular-disease-and-risk-factors
#13
M Yldau van der Ende, Minke H T Hartman, Yanick Hagemeijer, Laura M G Meems, Hendrik Sierd de Vries, Ronald P Stolk, Rudolf A de Boer, Anna Sijtsma, Peter van der Meer, Michiel Rienstra, Pim van der Harst
BACKGROUND: The LifeLines Cohort Study is a large three-generation prospective study and Biobank. Recruitment and data collection started in 2006 and follow-up is planned for 30years. The central aim of LifeLines is to understand healthy ageing in the 21st century. Here, the study design, methods, baseline and major cardiovascular phenotypes of the LifeLines Cohort Study are presented. METHODS AND RESULTS: Baseline cardiovascular phenotypes were defined in 9700 juvenile (8-18years) and 152,180 adult (≥18years) participants...
November 11, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27867121/effect-of-direct-stimulation-of-the-cochleovestibular-nerve-on-tinnitus-a-long-term-follow-up-study
#14
Minke J C van den Berge, J Marc C van Dijk, Rolien H Free, Janke Stienstra, Pim van Dijk, Bernard F A M van der Laan
OBJECTIVE: Tinnitus is a common entity that may lead to severe impairment in quality of life. An adequate treatment modality for severe tinnitus is currently lacking. Neurostimulation of the auditory tract may serve as a promising adjunct in tinnitus treatment. The aim is to investigate the effect of direct stimulation on the cochleovestibular nerve for intractable tinnitus. METHODS: This study was conducted at the University Medical Center Groningen, The Netherlands...
November 17, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27851201/1566-correlation-of-near-infrared-spectroscopy-with-cerebral-blood-flow-in-a-traumatic-brain-injury-model
#15
Diana Bruno, Alma Ramirez, Jose Decamps, Richard Mink
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850621/983-continuous-albuterol-delivery-via-high-flow-nasal-cannula-versus-aerosol-mask-in-status-asthmaticus
#16
Darci Evans, Dani Hoyle, Nick Anas, Richard Mink
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850394/756-inhibiting-guanine-deaminase-increases-guanine-high-energy-phosphates-in-cerebral-hypoxia-ischemia
#17
Jose Decamps, Alma Ramirez, Diana Bruno, Richard Mink
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850105/465-elevation-of-urinary-ngal-in-children-with-diabetic-ketoacidosis-and-the-effect-of-hyperchloremia
#18
Vaishali Benaka Hebbar, Alma Ramirez, Nick Anas, Jennifer Yee, Timmothy Flannery, Richard Mink
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27837421/otologic-and-audiologic-findings-in-22q11-2-deletion-syndrome
#19
E Verheij, A L Kist, A B Mink van der Molen, I Stegeman, G A van Zanten, W Grolman, H G X M Thomeer
Hearing loss is frequently present in the 22q11.2 deletion syndrome. Our aim was to describe the audiologic and otologic features of patients with 22q11.2 deletion syndrome. We conducted a retrospective cohort study in a single tertiary referral center. We reviewed medical files of all patients with 22q11.2 deletion syndrome who visited an otolaryngologist, plastic surgeon or speech therapist, for audiologic or otologic features. Hearing loss was defined as a pure tone average (of 0.5, 1, 2, and 4 kHz) of >20 decibel hearing level...
November 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27826805/why-is-cancer-genetic-counseling-underutilized-by-women-identified-as-at-risk-for-hereditary-breast-cancer-patient-perceptions-of-barriers-following-a-referral-letter
#20
Alyssa Kne, Heather Zierhut, Shari Baldinger, Karen K Swenson, Pamela Mink, Patricia McCarthy Veach, Michaela L Tsai
Family history information comprises an important tool in identifying and referring patients at risk for hereditary breast and ovarian cancer (HBOC) to cancer genetic counseling. Despite recommendations and support provided by numerous professional organizations, cancer genetic counseling services are underutilized by atrisk patients. This study aimed to: (1) determine the rate of genetic counseling utilization following a referral letter, (2) characterize factors (barriers and supports) which influenced uptake of services, and (3) identify potential strategies for increasing utilization...
November 8, 2016: Journal of Genetic Counseling
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