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https://www.readbyqxmd.com/read/29651426/4-hydroxy-2-nonenal-alkylated-and-peroxynitrite-nitrated-proteins-localize-to-the-fused-mitochondria-in-malpighian-epithelial-cells-of-type-iv-collagen-drosophila-mutants
#1
András A Kiss, Nikoletta Popovics, Zsolt Boldogkői, Katalin Csiszár, Mátyás Mink
Background . Human type IV collagenopathy is associated with mutations within the COL4A1 and to a less extent the COL4A2 genes. The proteins encoded by these genes form heterotrimers and are the highest molar ratio components of the ubiquitous basement membrane. The clinical manifestations of the COL4A1/A2 mutations are systemic affecting many tissues and organs among these kidneys. In order to uncover the cellular and biochemical alterations associated with aberrant type IV collagen, we have explored the phenotype of the Malpighian tubules, the secretory organ and insect kidney model, in col4a1 collagen gene mutants of the fruit fly Drosophila melanogaster ...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29649959/whole-brain-magnetic-resonance-spectroscopic-determinants-of-functional-outcomes-in-pediatric-moderate-severe-traumatic-brain-injury
#2
Talin Babikian, Jeffry R Alger, Monica U Ellis-Blied, Christopher C Giza, Emily Dennis, Alexander Olsen, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Paul Thompson, Robert F Asarnow
Diffuse axonal injury contributes to the long-term functional morbidity observed following pediatric moderate/severe traumatic brain injury (msTBI). Whole-Brain Proton Magnetic Resonance Echo-Planar Spectroscopic Imaging was used to measure the neurometabolite levels in the brain to delineate the course of disruption/repair during the first year post msTBI. The association between metabolite biomarkers and functional measures (cognitive functioning and CC function assessed by interhemispheric transfer time (IHTT) using an Event Related Potential paradigm) was also explored...
April 13, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29643486/experimentally-generated-randomness-certified-by-the-impossibility-of-superluminal-signals
#3
Peter Bierhorst, Emanuel Knill, Scott Glancy, Yanbao Zhang, Alan Mink, Stephen Jordan, Andrea Rommal, Yi-Kai Liu, Bradley Christensen, Sae Woo Nam, Martin J Stevens, Lynden K Shalm
From dice to modern electronic circuits, there have been many attempts to build better devices to generate random numbers. Randomness is fundamental to security and cryptographic systems and to safeguarding privacy. A key challenge with random-number generators is that it is hard to ensure that their outputs are unpredictable1-3 . For a random-number generator based on a physical process, such as a noisy classical system or an elementary quantum measurement, a detailed model that describes the underlying physics is necessary to assert unpredictability...
April 2018: Nature
https://www.readbyqxmd.com/read/29627866/replication-timing-of-large-sorex-granarius-soricidae-eulipotyphla-telomeres
#4
Julia M Minina, Tatjana V Karamysheva, Nicolaj B Rubtsov, Natalia S Zhdanova
Previously, we described the unique feature of telomeric regions in Iberian shrew Sorex granarius: its telomeres have two ranges of size, very small (3.8 kb of telomeric repeats on average) and very large discontinuous telomeres (213 kb) interrupted with 18S rDNA. In this study, we have demonstrated extraordinary replication pattern of S. granarius large telomeres that have not been shown before in other studied mammal. Using the ReD-FISH procedure, we observed prolonged, through S period, large telomere replication...
April 7, 2018: Protoplasma
https://www.readbyqxmd.com/read/29623614/effects-of-halogenated-contaminants-on-reproductive-development-in-wild-mink-neovison-vison-from-locations-in-canada
#5
John E Elliott, David Anthony Kirk, Pamela A Martin, Laurie K Wilson, Gabriela Kardosi, Sandi Lee, Tana McDaniel, Kimberley D Hughes, Barry D Smith, Abde Miftah Idrissi
The concept of the Anthropocene, that humans are now re-engineering global ecosystems, is in part evidenced by the pervasive pollution by persistent organic pollutants (POPs). Certain POPs are hormone mimics and can disrupt endocrine and hence reproductive processes, shown mainly by laboratory studies with model species. There are, in contrast, fewer confirmations of such disruption from eco-epidemiological studies of wild mammals. Here we used the American mink (Neovison vison) as a sentinel species for such a study...
April 6, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29617392/potential-niche-expansion-of-the-american-mink-invading-a-remote-island-free-of-native-predatory-mammals
#6
Ramiro D Crego, Jaime E Jiménez, Ricardo Rozzi
The success of an invasive species depends in part on its niche and the new niche opportunities that such species may find in the invaded habitat. Niche opportunities can be understood as the potential provided by a community to an invasive species to expand its niche by changes in habitat use, behavior, or diet, that favors population growth, reflected in the species occupying more habitat. This may occur under a favorable combination of access to resources that can be further favored by a lack of competitors and a release from natural enemies...
2018: PloS One
https://www.readbyqxmd.com/read/29611050/correction-to-radioiodine-ablation-with-1-850-mbq-in-association-with-rhtsh-in-patients-with-differentiated-thyroid-cancer
#7
Alberto S Tresoldi, Laura F Sburlati, Marcello Rodari, Mink S Schinkelshoek, Michela Perrino, Simone De Leo, Laura Montefusco, Paolo Colombo, Maura Arosio, Andrea Gerardo Antonio Lania, Laura Fugazzola, Arturo Chiti
Unfortunately, the fourth author's middle name was missed out in the original publication of this article. The complete correct name should read as follows.
April 2, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29606950/severe-adverse-reaction-to-vemurafenib-in-a-pregnant-woman-with-metastatic-melanoma
#8
Jorine de Haan, Johannes V van Thienen, Michael Casaer, Rebekka A Hannivoort, Kristel Van Calsteren, Minke van Tuyl, Mathilde M van Gerwen, Anne Debeer, Frédéric Amant, Rebecca C Painter
Targeted therapies have drastically changed the management of metastatic melanoma and have shown encouraging results on tumour progression but are also known for their high rates of adverse reactions. In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis. For the BRAF V600 inhibitor vemurafenib, the available literature about the effects on human pregnancy is limited to a single case report. In patients with metastatic melanoma that wish to continue their pregnancy, targeted therapies like vemurafenib offer the only possibility of improving maternal outcome...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29600549/phenotypes-genotypes-and-the-management-of-paroxysmal-movement-disorders
#9
REVIEW
Laura Silveira-Moriyama, Stjepana Kovac, Manju A Kurian, Henry Houlden, Andrew J Lees, Matthew C Walker, Emmanuel Roze, Alex R Paciorkowski, Jonathan W Mink, Thomas T Warner
As a consequence of the genomic revolution, a large number of publications describing paroxysmal movement disorders have been published in the last few years, shedding light on their molecular pathology. Routine gene testing is not necessary to guide treatment for typical forms of paroxysmal kinesigenic dyskinesia (PKD), paroxysmal nonkinesigenic dyskinesia (PNKD), and episodic ataxia type 1 or 2. It can, however, be helpful in the management of atypical or complex cases, especially for genetic counselling, treatment strategies, and the offer of preimplantation genetic diagnosis...
March 30, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29575609/lncrna-malat1-promotes-lung-adenocarcinoma-by-directly-interacting-with-sp1
#10
Shufeng Li, Fang Ma, Kunpeng Jiang, Haitao Shan, Minke Shi, Baojun Chen
Metastasis-associated lung adenocarcinoma transcript 1 (Malat1) is an oncogenic long non-coding RNA (lncRNA), which has been proved to be associated with various kinds of tumors. The transcription factor Specificity Protein 1 (SP1) is over-expressed in many types of cancers. Previously we already observed that malat1 expression level is regulated by SP1 in lung cancer. In this study, we find that transfection of expression construct of malat1 5'end fragment M5 enhances stability and transcriptional activity of SP1; Various SP1 target genes are also upregulated following overexpression of malat1 M5 in lung adenocarcinoma cells...
March 25, 2018: Cancer Science
https://www.readbyqxmd.com/read/29573713/river-otters-lontra-canadensis-trapped-in-a-coastal-environment-contaminated-with-persistent-organic-pollutants-demographic-and-physiological-consequences
#11
Andrew C Huang, Cait Nelson, John E Elliott, Daniel A Guertin, Carol Ritland, Ken Drouillard, Kimberly M Cheng, Helen M Schwantje
Productive coastal and estuarine habitats can be degraded by contaminants including persistent organic pollutants (POPs) such as PCBs, dioxins, and organochlorine insecticides to the extent of official designation as contaminated sites. Top-predatory wildlife may continue to use such sites as the habitat often appears suitable, and thus bioaccumulate POPs and other contaminants with potential consequences on their health and fitness. Victoria and Esquimalt harbours are located on southern Vancouver Island, British Columbia (BC) and are federally designated contaminated sites due mainly to past heavy industrial activities, such as from shipyards and sawmills...
March 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29573521/activation-of-the-igf1-receptor-stimulates-glycogen-synthesis-by-mink-uterine-epithelial-cells
#12
Matthew Dean, Jack Rose
Glycogen synthesis by mink uterine epithelial cells is stimulated by estradiol (E2 ) during estrus, although the mechanism/s through which the steroid promotes glycogen accumulation are unknown. Our aim was to determine if insulin is required for E2 induced glycogen synthesis by an immortalized mink uterine epithelial cell line (GMMe). We show that the cells expressed the genes for glycogen metabolizing enzymes (hexokinase 1, glucose-6-phosphatase 3, glycogen synthase 1 and glycogen phosphorylase-muscle), receptors for insulin, insulin-like growth factor 1 and E2 (Esr1)...
March 24, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29561713/parental-attitude-toward-the-prenatal-diagnosis-of-oral-cleft-a-prospective-cohort-study
#13
Wies Maarse, Chantal W B Boonacker, Henriette F N Swanenburg de Veye, Moshe Kon, Corstiaan C Breugem, Aebele B Mink van der Molen, Johannes J M van Delden
OBJECTIVES: The prenatal diagnosis of oral clefts (OCs) by ultrasound can pose an ethical dilemma. The purpose of this study was to obtain insight into the psychosocial and moral considerations of prospective parents concerning OCs, the burden of OCs and parents' attitude toward possible termination of pregnancy (TOP) in order to improve counseling in the future. DESIGN: Between August 2011 and August 2014, a prospective cohort questionnaire study was administered...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29529183/identification-of-influencing-factors-and-strategies-to-improve-communication-between-general-practitioners-and-community-nurses-a-qualitative-focus-group-study
#14
Minke S Nieuwboer, Marieke Perry, Rob van der Sande, Irma T H M Maassen, Marcel G M Olde Rikkert, Marjolein A van der Marck
Background: As the number of patients with complex healthcare needs grows, inter-professional collaboration between primary care professionals must be constantly optimized. General practitioners (GPs) and community nurses (CNs) are key professions in primary care; however, poor GP-CN communication is common, and research into the factors influencing its quality is limited. Objective: To explore patient-related GP-CN communication and facilitating and hindering factors, and to identify strategies to enhance this communication...
February 26, 2018: Family Practice
https://www.readbyqxmd.com/read/29519701/translational-overview-of-cytokine-inhibition-in-acute-myocardial-infarction-and-chronic-heart-failure
#15
REVIEW
Minke H T Hartman, Hilde E Groot, Irene Mateo Leach, Jacco C Karper, Pim van der Harst
Many cytokines are currently under investigation as potential target to improve cardiac function and outcome in the setting of acute myocardial infarction (MI) or chronic heart failure (HF). Here we aim to provide a translational overview of cytokine inhibiting therapies tested in experimental models and clinical studies. In various experimental studies, inhibition of interleukin-1 (IL-1), -6 (IL-6), -8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), CC- and CXC chemokines, and tumor necrosis factor-α (TNF-α) had beneficial effects on cardiac function and outcome...
February 15, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29519524/identification-of-arcanobacterium-phocae-isolated-from-fur-animals-by-phenotypic-properties-by-maldi-tof-ms-analysis-and-by-detection-of-phocaelysin-encoding-gene-phl-as-probable-novel-target
#16
Mazen Alssahen, Osama Sammra, Jörn-Peter Wickhorst, Abdulwahed Ahmed Hassan, Christoph Lämmler, Mirja Raunio Saarnisto, Ellen Prenger-Berninghoff, Markus Timke, Andrè Becker, Amir Abdulmawjood
In the present study 12 Arcanobacterium phocae strains isolated from fur animals in Finland, including foxes, minks and Finnraccoons, could successfully be identified phenotypically, by matrix-assisted laser desorption ionisation-time of flight mass spectrometry (MALDI-TOF MS) and genotypically by sequencing 16S rDNA and phocaelysin (PHL) encoding gene phl. The PHL of all 12 A. phocae strains in the present study and reference strains A. phocae DSM 10002T and A. phocae DSM 10003 displayed, as typical members of the cholesterol dependent cytolysin-group of toxins, the variant undecapeptide sequence EATGLAWDPWW which appeared to be most closely related to arcanolysin of Arcanobacterium haemolyticum and pyolysin of Trueperella pyogenes...
March 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29504180/decreased-body-mass-index-during-treatment-with-sodium-oxybate-in-narcolepsy-type-1
#17
Mink S Schinkelshoek, Isabelle M Smolders, Claire E Donjacour, Wisse P van der Meijden, Erik W van Zwet, Rolf Fronczek, Gert Jan Lammers
Narcolepsy type 1 is characterised by an increase in body weight after disease onset, frequently leading to obesity. It was suggested that this weight gain may be counteracted by treatment with sodium oxybate. We here provide longitudinal body mass index data of patients with narcolepsy type 1 after starting treatment with sodium oxybate, compared with patients in whom treatment with modafinil was initiated. Eighty-one individuals with narcolepsy type 1 fulfilled the entry criteria for this retrospective study: 59 had newly started treatment with sodium oxybate and 22 had newly started modafinil...
March 4, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29501532/rapid-and-sensitive-detection-of-mink-circovirus-by-recombinase-polymerase-amplification
#18
Junwei Ge, Yunjia Shi, Xingyang Cui, Shanshan Gu, Lili Zhao, Hongyan Chen
To date, the pathogenic role of mink circovirus (MiCV) remains unclear, and its prevalence and economic importance are unknown. Therefore, a rapid and sensitive molecular diagnosis is necessary for disease management and epidemiological surveillance. However, only PCR methods can identify MiCV infection at present. In this study, we developed a nested PCR and established a novel recombinase polymerase amplification (RPA) assay for MiCV detection. Sensitivity analysis showed that the detection limit of nested PCR and RPA assay was 101 copies/reaction, and these methods were more sensitive than conventional PCR, which has a detection limit of 105 copies/reaction...
February 28, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29500690/chevrier-s-field-mouse-apodemus-chevrieri-and-p%C3%A3-re-david-s-vole-eothenomys-melanogaster-in-china-carry-orthohepeviruses-that-form-two-putative-novel-genotypes-within-the-species-orthohepevirus-c
#19
Bo Wang, Wen Li, Ji-Hua Zhou, Bei Li, Wei Zhang, Wei-Hong Yang, Hong Pan, Li-Xia Wang, C Thomas Bock, Zheng-Li Shi, Yun-Zhi Zhang, Xing-Lou Yang
Hepatitis E virus (HEV) is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis. Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. In this study, we tested 278 specimens collected from seven wild small mammal species in Yunnan province, China, for the presence and prevalence of orthohepevirus by broad-spectrum reverse transcription (RT)-PCR. HEV-related sequences were detected in two rodent species, including Chevrier's field mouse (Apodemus chevrieri, family Muridae) and Père David's vole (Eothenomys melanogaster, family Cricetidae), with the infection rates of 29...
March 2, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29492661/mortality-in-robin-sequence-identification-of-risk-factors
#20
Robrecht J H Logjes, Maartje Haasnoot, Petra M A Lemmers, Mike F A Nicolaije, Marie-José H van den Boogaard, Aebele B Mink van der Molen, Corstiaan C Breugem
Although Robin sequence (RS) is a well-known phenomenon, it is still associated with considerable morbidity and even mortality. The purposes of this study were to gain greater insight into the mortality rate and identify risk factors associated with mortality in RS. We retrospectively reviewed all RS infants followed at the Wilhelmina Children's Hospital from 1995 to 2016. Outcome measurements were death and causes of death. The authors identified 103 consecutive RS infants with a median follow-up of 8.6 years (range 0...
February 28, 2018: European Journal of Pediatrics
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