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https://www.readbyqxmd.com/read/29455324/genetic-diversity-and-phylogenetic-analysis-of-aleutian-mink-disease-virus-isolates-in-north-east-china
#1
Xue Leng, Dongxu Liu, Jianming Li, Kun Shi, Fanli Zeng, Ying Zong, Yi Liu, Zhibo Sun, Shanshan Zhang, Yadong Liu, Rui Du
Aleutian mink disease is the most important disease in the mink-farming industry worldwide. So far, few large-scale molecular epidemiological studies of AMDV, based on the NS1 and VP2 genes, have been conducted in China. Here, eight new Chinese isolates of AMDV from three provinces in north-east China were analyzed to clarify the molecular epidemiology of AMDV. The seroprevalence of AMDV in north-east China was 41.8% according to counterimmuno-electrophoresis. Genetic variation analysis of the eight isolates showed significant non-synonymous substitutions in the NS1 and VP2 genes, especially in the NS1 gene...
February 17, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29450884/is-sonographically-measured-cervical-length-at-37-weeks-gestation-associated-with-intrapartum-cesarean-section-a-prospective-cohort-study
#2
Bradley de Vries, Rajit Narayan, Kevin McGeechan, Stanley Santiagu, Ramesh Vairavan, Minke Burke, Hala Phipps, Jon Hyett
Cesarean section rates continue to increase globally. Prediction of intrapartum cesarean section could lead to preventative measures. Our aim was to assess the association between sonographically measured cervical length at 37 weeks' gestation and cesarean section among women planning a vaginal birth. The population was women with a low risk pregnancy or with gestational diabetes MATERIAL AND METHODS: This was a prospective cohort study conducted in a tertiary referral hospital in Sydney, Australia. 212 women with a low risk pregnancy or with gestational diabetes were recruited including 158 nulliparous and 54 parous women...
February 16, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29444113/effects-of-protein-protein-interactions-and-ligand-binding-on-the-ion-permeation-in-kcnq1-potassium-channel
#3
Horia Jalily Hasani, Aravindhan Ganesan, Marawan Ahmed, Khaled H Barakat
The voltage-gated KCNQ1 potassium ion channel interacts with the type I transmembrane protein minK (KCNE1) to generate the slow delayed rectifier (IKs) current in the heart. Mutations in these transmembrane proteins have been linked with several heart-related issues, including long QT syndromes (LQTS), congenital atrial fibrillation, and short QT syndrome. Off-target interactions of several drugs with that of KCNQ1/KCNE1 ion channel complex have been known to cause fatal cardiac irregularities. Thus, KCNQ1/KCNE1 remains an important avenue for drug-design and discovery research...
2018: PloS One
https://www.readbyqxmd.com/read/29433401/amdoparvovirus-infection-in-red-pandas-ailurus-fulgens
#4
Charles E Alex, Steven V Kubiski, Linlin Li, Mohammadreza Sadeghi, Raymund F Wack, Megan A McCarthy, Joseph B Pesavento, Eric Delwart, Patricia A Pesavento
Aleutian mink disease virus is the type species in the genus Amdoparvovirus, and in mink and other Mustelidae can cause either subclinical disease or fatal chronic immune stimulation and immune complex disease. The authors describe a novel amdoparvovirus in the endangered red panda ( Ailurus fulgens), discovered using viral metagenomics. The authors analyzed the prevalence, tissue distribution, and disease association by PCR, in situ hybridization, electron microscopy, and histology in a group of 6 red pandas from a single zoological collection...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29420618/recombinant-expression-purification-and-biochemical-characterization-of-kievitone-hydratase-from-nectria-haematococca
#5
Matthias Engleder, Melissa Horvat, Anita Emmerstorfer-Augustin, Tamara Wriessnegger, Stefanie Gabriel, Gernot Strohmeier, Hansjörg Weber, Monika Müller, Iwona Kaluzna, Daniel Mink, Martin Schürmann, Harald Pichler
Kievitone hydratase catalyzes the addition of water to the double bond of the prenyl moiety of plant isoflavonoid kievitone and, thereby, forms the tertiary alcohol hydroxy-kievitone. In nature, this conversion is associated with a defense mechanism of fungal pathogens against phytoalexins generated by host plants after infection. As of today, a gene sequence coding for kievitone hydratase activity has only been identified and characterized in Fusarium solani f. sp. phaseoli. Here, we report on the identification of a putative kievitone hydratase sequence in Nectria haematococca (NhKHS), the teleomorph state of F...
2018: PloS One
https://www.readbyqxmd.com/read/29405267/pharmacological-and-neurosurgical-interventions-for-managing-dystonia-in-cerebral-palsy-a-systematic-review
#6
Darcy Fehlings, Leah Brown, Adrienne Harvey, Kate Himmelmann, Jean-Pierre Lin, Alexander Macintosh, Jonathan W Mink, Elegast Monbaliu, James Rice, Jessica Silver, Lauren Switzer, Ilana Walters
AIM: To systematically review evidence for pharmacological/neurosurgical interventions for managing dystonia in individuals with cerebral palsy (CP) to inform a care pathway. METHOD: Searches included studies with a minimum of five participants with dystonia in CP receiving oral baclofen, benzodiazepines (clonazepam, diazepam, lorazepam), clonidine, gabapentin, levodopa, trihexyphenidyl, botulinum toxin, intrathecal baclofen (ITB), or deep brain stimulation (DBS)...
February 6, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29396175/basal-ganglia-mechanisms-in-action-selection-plasticity-and-dystonia
#7
REVIEW
Jonathan W Mink
Basal ganglia circuits are organized to selected desired actions and to inhibit potentially competing unwanted actions. This is accomplished through a complex circuitry that is modified through development and learning. Mechanisms of neural plasticity underlying these modifications are increasingly understood, but new mechanisms continue to be discovered. Dystonia, a movement disorder characterized by involuntary muscle contractions that cause abnormal postures and movements. Emerging evidence points to important links between mechanisms of plasticity and the manifestations of dystonia...
January 17, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29381632/reliability-of-the-dutch-cleft-speech-evaluation-test-and-conversion-to-the-proposed-universal-scale
#8
Nicole E Spruijt, Marije Beenakker, Maud Verbeek, Zavira C M Heinze, Corstiaan C Breugem, Aebele B Mink van der Molen
The Dutch cleft speech evaluation test (DCSET) has been implemented by the speech-language pathologists nationwide in the Netherlands since 2003, but the inter- and intrarater reliability was unknown. Two speech-language pathologists experienced in evaluating cleft speech assessed audio recordings of 20 children with cleft speech using the DCSET, and reassessed the recordings 2 weeks later. Intra- and interrater reliability was calculated, but found to be unacceptable after the first phase of this study using audio recordings...
January 19, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29373971/development-and-application-of-an-indirect-enzyme-linked-immunosorbent-assay-based-on-recombinant-capsid-protein-for-the-detection-of-mink-circovirus-infection
#9
Junwei Ge, Xingyang Cui, Yunjia Shi, Lili Zhao, Chengwei Wei, Shanshan Wen, Shuang Xia, Hongyan Chen
BACKGROUND: Mink circovirus (MiCV) is a newly discovered pathogen associated with mink diarrhea. The prevalence and economic importance of this virus remain poorly understood, and no specific serological assay has been developed for the diagnosis of MiCV infection. RESULTS: In this study, a recombinant capsid protein antigen expressed in Escherichia coli was utilized to establish an indirect enzyme-linked immunosorbent assay (iELISA). Results revealed that the assay had no cross-reactivity with other related pathogens, and the respective sensitivity and specificity of the proposed iELISA were 92...
January 26, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29370784/students%C3%A2-perception-of-interprofessional-education-in-the-bachelor-programme-interprofessional-health-care-in-heidelberg-germany-an-exploratory-case-study
#10
Cornelia Mahler, Veronika Schwarzbeck, Johanna Mink, Katja Goetz
BACKGROUND: Interprofessional education is receiving increased attention worldwide. This has led to the development of a bachelor programme "Interprofessional Health Care" at the University of Heidelberg, Germany beginning in the winter semester 2011. Aim of this study was to evaluate the students' perception of this innovative programme regarding interprofessional learning. METHODS: An exploratory case study was conducted. A semi-structured guideline was developed and seven focus groups were performed with the students of the first three cohorts in 2012-2014...
January 25, 2018: BMC Medical Education
https://www.readbyqxmd.com/read/29355551/baseline-and-serial-brain-natriuretic-peptide-level-predicts-5-year-overall-survival-in-patients-with-pulmonary-arterial-hypertension-data-from-the-reveal-registry
#11
Robert P Frantz, Harrison W Farber, David B Badesch, C Greg Elliott, Adaani E Frost, Michael D McGoon, Carol Zhao, David R Mink, Mona Selej, Raymond L Benza
BACKGROUND: Plasma brain natriuretic peptide (BNP) level is a prognostic biomarker in pulmonary arterial hypertension (PAH). Its impact on long-term overall survival (OS) was investigated in the Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension Disease Management (REVEAL), a 5-year observational, multicenter, US registry of patients with PAH. METHODS: Patients were ≥ 18 years of age, met right heart catheterization criteria at rest, had World Health Organization group I PAH, and had BNP measurement at enrollment...
January 16, 2018: Chest
https://www.readbyqxmd.com/read/29351775/vaccine-resistant-pseudorabies-virus-causes-mink-infection-in-china
#12
Gui-Sheng Wang, Yijun Du, Jia-Qiang Wu, Fu-Lin Tian, Xue-Jie Yu, Jin-Bao Wang
BACKGROUND: Pseudorabies, a highly contagious infectious disease of swine is caused by pseudorabies virus (PRV). PRV can cause fatal infection in other animal species. RESULTS: We report a deadly outbreak of pseudorabies that killed 87.2% (3522/4028) minks in a farm in 2014 in Shandong Province, China. PRV was isolated by using Vero cell culture and detected in mink samples by PCR from minks died during the outbreak. Epidemiological analysis indicated that 5.8% of minks (33/566) were PCR positive to PRV in Shandong Province...
January 19, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29333687/h9n2-influenza-virus-isolated-from-minks-has-enhanced-virulence-in-mice
#13
R Xue, Y Tian, T Hou, D Bao, H Chen, Q Teng, J Yang, X Li, G Wang, Z Li, Q Liu
H9N2 is one of the major subtypes of influenza virus circulating in poultry in China, which has a wide host range from bird to mammals. Two H9N2 viruses were isolated from one mink farm in 2014. Phylogenetic analysis showed that internal genes of the H9N2 viruses have close relationship with those of H7N9 viruses. Interestingly, two H9N2 were separated in phylogenetic trees, indicating that they are introduced to this mink farm in two independent events. And further mice studies showed that one H9N2 caused obvious weight loss and 20% mortality in infected mice, while another virus did not cause any clinical sign in mice infected at the same dose...
January 14, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29331408/long-term-craniofacial-morphology-in-young-adults-treated-for-a-non-syndromal-uclp-a-systematic-review
#14
REVIEW
Isabelle F P M Kappen, Whitney R Yoder, Aebele B Mink van der Molen, Corstiaan C Breugem
Minimizing mid-facial growth impairment is one of the treatment goals in cleft lip and palate surgery. As growth of the maxilla extends into young adulthood, long-term evaluation is essential to make a comprehensive assessment of a treatment protocol. There are numerous treatment approaches for cleft lip/palate surgery, and most have the characteristic distinction between either an early or a late cleft palate closure. PRISMA guidelines were applied to explore the quality of the current literature and to identify treatment factors influencing long-term cephalometric outcomes...
December 13, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29318377/the-number-of-neurons-in-specific-amygdala-regions-is-associated-with-boldness-in-mink-a-study-in-animal-personality
#15
Ann-Sophie Wiese, Esther Kjær Needham, Christina Lehmkuhl Noer, Thorsten Johannes Skovbjerg Balsby, Torben Dabelsteen, Bente Pakkenberg
Conspecifics vary consistently in their behavioural responses towards environment stimuli such as exposure to novel objects; ethologists often refer to this variability as animal personality. The neurological mechanisms underlying animal personality traits remain largely unknown, but linking the individual variation in emotional expression to brain structural and neurochemical factors is attracting renewed interest. While considerable research has focused on hormonal and neurotransmitter effects on behavioural responses, less is known about how individual variation in the number of specific neuron populations contributes to individual variation in behaviour...
January 9, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29303065/clinical-research-of-combined-intravenous-administration-and-topical-application-of-tranexamic-acid-to-a-surgical-wound-during-posterior-lumbar-fusion
#16
Yufu Ou, Jianxun Wei, Rongzhu Li, Bin Liang, Dezan Qiu, Minke Wei, Xiaoping Mu, Zhuhai Li
BACKGROUND: The safety and effectiveness of combined intravenous and topical administration of tranexamic acid (TXA) on the reduction of blood loss in patients undergoing posterior lumbar fusion are not yet clear. The study aimed to investigate the safety and effectiveness of the combined intravenous and topical administration of TXA on the reduction of blood loss in patients undergoing posterior lumbar fusion. METHOD: One hundred and eighteen patients who underwent double-segment posterior lumbar decompression and fusion from February 2014 to May 2016 in our hospital were retrospectively reviewed...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29302009/an-excess-of-massive-stars-in-the-local-30-doradus-starburst
#17
F R N Schneider, H Sana, C J Evans, J M Bestenlehner, N Castro, L Fossati, G Gräfener, N Langer, O H Ramírez-Agudelo, C Sabín-Sanjulián, S Simón-Díaz, F Tramper, P A Crowther, A de Koter, S E de Mink, P L Dufton, M Garcia, M Gieles, V Hénault-Brunet, A Herrero, R G Izzard, V Kalari, D J Lennon, J Maíz Apellániz, N Markova, F Najarro, Ph Podsiadlowski, J Puls, W D Taylor, J Th van Loon, J S Vink, C Norman
The 30 Doradus star-forming region in the Large Magellanic Cloud is a nearby analog of large star-formation events in the distant universe. We determined the recent formation history and the initial mass function (IMF) of massive stars in 30 Doradus on the basis of spectroscopic observations of 247 stars more massive than 15 solar masses ([Formula: see text]). The main episode of massive star formation began about 8 million years (My) ago, and the star-formation rate seems to have declined in the last 1 My...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29297313/a-compendium-and-functional-characterization-of-mammalian-genes-involved-in-adaptation-to-arctic-or-antarctic-environments
#18
Nikolay S Yudin, Denis M Larkin, Elena V Ignatieva
BACKGROUND: Many mammals are well adapted to surviving in extremely cold environments. These species have likely accumulated genetic changes that help them efficiently cope with low temperatures. It is not known whether the same genes related to cold adaptation in one species would be under selection in another species. The aims of this study therefore were: to create a compendium of mammalian genes related to adaptations to a low temperature environment; to identify genes related to cold tolerance that have been subjected to independent positive selection in several species; to determine promising candidate genes/pathways/organs for further empirical research on cold adaptation in mammals...
December 28, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29287846/congenital-respiratory-tract-disorders-in-22q11-2-deletion-syndrome
#19
Emmy Verheij, Lucienne Speleman, Aebele B Mink van der Molen, Henricus G X M Thomeer
OBJECTIVE: Respiratory tract disorders have been reported in patients with 22q11.2 deletion syndrome, however infrequently. This study describes the respiratory tract disorders encountered in a cohort of 278 patients with 22q11.2 deletion syndrome. METHODS: We conducted a retrospective, cross-sectional, study at a single tertiary referral center. We identified the patients with 22q11.2 deletion syndrome and with an upper and/or lower respiratory tract disorder at our otorhinolaryngologic department...
January 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29278728/identification-and-characterization-of-a-novel-b-cell-epitope-on-aleutian-mink-disease-virus-capsid-protein-vp2-using-a-monoclonal-antibody
#20
Taofeng Lu, Yuanzhi Wang, Junwei Ge, Qin Ma, Wenzhuo Yan, Yuanyuan Zhang, Lili Zhao, Hongyan Chen
Aleutian mink disease is caused by a highly contagious parvovirus (Aleutian mink disease virus, AMDV). This disease is one of the most commercially important infectious disease worldwide and causes considerable economic losses to mink farmers. The capsid protein VP2 is the major immunogenic antigenic protein of AMDV, and is involved in viral tropism, pathogenicity, and host selection. However, few reports have described the use of VP2-specific monoclonal antibodies (mAbs) in B-cell epitope identification and immunological detection...
December 23, 2017: Virus Research
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