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https://www.readbyqxmd.com/read/28229615/bacteremia-with-raoultella-planticola-in-the-setting-of-acute-pancreatitis-complicated-with-acute-cholangitis
#1
Esther Merino Rodríguez, Susana Rebolledo Olmedo, Joaquín Miquel Plaza
The bacterium Raoultella planticola (R planticola) is a rare pathogen in humans. We report a case of mild acute pancreatitis (MAP) of biliary origin with cholangitis and bacteremia with R planticola in association with pancreatic panniculitis (PP). A 55-year-old woman with rheumatic multiple valvulopathy presented with epigastric pain radiating to the back in a belt-like fashion for 48 hours, jaundice, choluria, acholia, and fever (38.2oC). Lab tests showed: amylase 2126 U/L, ALT 124 U/L, AST 169 U/L, GGT 3548 U/L, AP 1516 U/L, TBil 12...
February 23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28224048/wound-penetration-of-cefazolin-ciprofloxacin-piperacillin-tazobactam-and-vancomycin-during-negative-pressure-wound-therapy
#2
Matthew P Rowan, Krista L Niece, Julie A Rizzo, Kevin S Akers
Objective: Negative pressure wound therapy (NPWT) uses subatmospheric pressure as a noninvasive adjunct to treat wounds and has demonstrated clinical efficacy by accelerating healing of a variety of acute and chronic wounds. NPWT may also play a role in preventing or treating wound infections, possibly by increasing wound penetration of antibiotics. However, clinical data in patients undergoing antibiotic and NPWT treatment are limited. Approach: To evaluate the wound penetration of antibiotics in NPWT patients, we conducted a prospective, observational study of burn and trauma patients treated with NPWT and systemic antibiotics...
February 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28222788/antimicrobial-resistance-and-genomic-rep-pcr-fingerprints-of-pseudomonas-aeruginosa-strains-from-animals-on-the-background-of-the-global-population-structure
#3
Isa Serrano, Manuela Oliveira, José Pedro Santos, Florence Bilocq, Alexandre Leitão, Luis Tavares, Jean-Paul Pirnay, Daniel De Vos
BACKGROUND: Pseudomonas aeruginosa is an important human opportunistic pathogen responsible for fatal nosocomial infections worldwide, and has emerged as a relevant animal pathogen. Treatment options are dramatically decreasing, due to antimicrobial resistance and the microorganism's large versatile genome. Antimicrobial resistance profiles, serotype frequency and genomic profile of unrelated P. aeruginosa isolates of veterinary origin (n = 73), including domesticated, farm, zoo and wild animals mainly from Portugal were studied...
February 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28222483/prevalence-and-characteristics-of-fecal-antimicrobial-resistant-escherichia-coli-in-a-cohort-of-japanese-men-undergoing-prostate-biopsy
#4
Jun Kamei, Yuka Yagihara, Haruki Kume, Takamasa Horiuchi, Tomoaki Sato, Tohru Nakagawa, Tetsuya Fujimura, Hiroshi Fukuhara, Kyoji Moriya, Yukio Homma
OBJECTIVES: To examine resistant Escherichia coli in rectal swab culture of Japanese men undergoing prostate biopsy, and to determine its prevalence, genotypic characteristics and carriage risk factors. METHODS: Rectal swabs of consecutive men undergoing transrectal ultrasound-guided prostate biopsy from April 2013 to March 2015 were cultured to isolate fluoroquinolone-resistant and extended-spectrum β-lactamase-producing E. coli. The prevalence and antimicrobial susceptibility of these resistant E...
February 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28221899/improvement-of-karmali-agar-by-supplementation-with-tazobactam-for-detecting-campylobacter-in-raw-poultry
#5
Young-Ji Kim, Chon-Jung Whan, Hong-Seok Kim, Kwang-Yeop Kim, Jin-Hyeok Yim, Seung-Hak Cho, Kun-Ho Seo
In this study, Karmali agar was modified by adding tazobactam (T-Karmali agar) to suppress the growth of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli , which frequently contaminates raw poultry meat. By inoculating 30 Campylobacter spp. strains and 25 ESBL-producing E. coli strains onto Karmali agar and T-Karmali agar containing various concentrations of the antibacterial agent, we determined the optimum concentration of tazobactam to be 4 mg/liter. The Campylobacter spp. isolation rate on T-Karmali agar (13...
November 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28217763/impact-of-tigecycline-versus-other-antibiotics-on-the-fecal-metabolome-and-on-colonization-resistance-to-clostridium-difficile-in-mice
#6
Robin L P Jump, David Kraft, Kelly Hurless, Alex Polinkovsky, Curtis J Donskey
BACKGROUND: The glycylcycline antibiotic tigecycline may have a relatively low propensity to promote Clostridium difficile infection in part because it causes less disruption of the indigenous intestinal microbiota than other broad-spectrum antibiotics. We used a mouse model to compare the effects of tigecycline versus other commonly used antibiotics on colonization resistance to C. difficile and on the metabolic functions of the intestinal microbiota. METHODS: To assess in vivo colonization resistance to C...
January 18, 2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28216097/epidemiology-and-resistance-characteristics-of-pseudomonas-aeruginosa-isolates-from-the-respiratory-department-of-a-hospital-in-china
#7
Wei Feng, Fengjun Sun, Qian Wang, Wei Xiong, Xuewen Qiu, Xiaotian Dai, Peiyuan Xia
OBJECTIVES: Pseudomonas aeruginosa is one of the most common pathogens causing nosocomial pneumonia. The aim of this study was to investigate the epidemiology and resistance of P. aeruginosa isolated from hospitalised patients in the respiratory department of a hospital in China. METHODS: Clinical isolates were collected from the respiratory department of Southwest Hospital (Chongqing, China) from January 2013 to December 2014. Patients' social and demographic information was obtained from the hospital's information system...
February 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28213015/lettuce-and-fruits-as-a-source-of-multidrug-resistant-acinetobacter-spp
#8
Ana Carvalheira, Joana Silva, Paula Teixeira
The role of ready-to-eat products as a reservoir of pathogenic species of Acinetobacter remains unclear. The objective of the present study was to evaluate the presence of Acinetobacter species in lettuces and fruits marketed in Portugal, and their susceptibility to antimicrobials. Acinetobacter spp. were isolated from 77.9% of the samples and these microorganisms were also found as endophytes (i.e. present within the plant tissue) in 12 of 20 samples of lettuces analysed. Among 253 isolates that were identified as belonging to this genus, 181 presented different PFGE profiles, representing different strains...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28209320/comparison-of-the-incidence-of-acute-kidney-injury-during-treatment-with-vancomycin-in-combination-with-piperacillin-tazobactam-or-with-meropenem
#9
Majed S Al Yami
The purpose of this study was to evaluate the observed incidence of acute kidney injury (AKI) in adult patients receiving either piperacillin-tazobactam (PT) and vancomycin or meropenem and vancomycin for at least 48h. In this retrospective cohort study, we included adult patients with no known renal dysfunction who received either the combination of PT-vancomycin or meropenem-vancomycin for at least 48h. The study's primary outcome was the incidence of acute kidney injury (AKI), defined by the Kidney Disease: Improving Global Outcomes (KDIGO) in patients with baseline normal renal function as an increase in serum creatinine (Scr) by ≥0...
February 10, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28207768/prevalence-of-mdr-pathogens-of-bacterial-meningitis-in-egypt-and-new-synergistic-antibiotic-combinations
#10
Mona M Abdelkader, Khaled M Aboshanab, Marwa A El-Ashry, Mohammad M Aboulwafa
The aim of this study was identifying bacterial pathogens involved in meningitis, studying their antibiotic resistance profiles, investigating the antibiotic resistance genes as well as evaluating the use of various antibiotic combinations. Antibiotic susceptibility tests were evaluated according to CLSI guidelines. Antibiotic combinations were evaluated by calculating the Fractional Inhibitory Concentration (FIC) index. A total of 71 bacterial isolates were recovered from 68 culture positive CSF specimens...
2017: PloS One
https://www.readbyqxmd.com/read/28203427/potency-of-parenteral-antimicrobials-including-ceftolozane-tazobactam-against-nosocomial-respiratory-tract-pathogens-considerations-for-empiric-and-directed-therapy
#11
Christina A Sutherland, David P Nicolau
BACKGROUND: Empiric therapy decisions are predicated on knowledge of both the epidemiology and antimicrobial susceptibility of the probable infecting pathogen(s). The objective of this study was to evaluate the microbial distribution and phenotypic profiles of nosocomial respiratory isolates collected from multiple US hospitals and assess the clinical utility of various monotherapy and combination regimens. METHODS: Hospitals provided consecutive non-duplicate adult inpatients Gram-negative nosocomial respiratory isolates from cultures received ≥48 h after hospital admission...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28182801/acute-kidney-injury-in-patients-treated-with-vancomycin-and-piperacillin-tazobactam-a-retrospective-cohort-analysis
#12
W Cliff Rutter, Donna R Burgess, Jeffery C Talbert, David S Burgess
BACKGROUND: Empiric antimicrobial therapy often consists of the combination of gram-positive coverage with vancomycin (VAN) and gram-negative coverage, specifically an antipseudomonal beta-lactam such as piperacillin-tazobactam (PTZ). Nephrotoxicity is commonly associated with VAN therapy; however, recent reports show higher nephrotoxicity rates among patients treated with the combination of VAN and PTZ. OBJECTIVE: This study evaluated the effect of the VAN/PTZ combination on acute kidney injury (AKI) compared to VAN and PTZ monotherapies...
February 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28182208/systematic-review-and-metaanalysis-of-acute-kidney-injury-associated-with-concomitant-vancomycin-and-piperacillin-tazobactam
#13
Drayton A Hammond, Melanie N Smith, Chenghui Li, Sarah M Hayes, Katherine Lusardi, P Brandon Bookstaver
No abstract text is available yet for this article.
February 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28181269/-99m-tc-tazobactam-a-novel-infection-imaging-agent-radiosynthesis-quality-control-biodistribution-and-infection-imaging-studies
#14
Rashid Rasheed, Syed Ali Raza Naqvi, Syed Jawad Hussain Gillani, Ameer Fawad Zahoor, Asif Jielani, Nidda Saeed
The radiolabeled drug (99m) Tc-tazobactam ((99m) Tc-TZB) was developed and assessed as an infection imaging agent in P. aeruginosa and S. enterica infection induced animal models by comparing with inflammation induced animal models. Radiosynthesis of (99m) Tc-TZB was assessed while changing ligand concentration, reducing agent concentration, pH and reaction time while keeping radioactivity constant (~370 MBq). Percent labeling of the resulting complex was measured using paper chromatography and instant thin layer chromatography (ITLC-SG)...
February 8, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28167857/high-frequency-of-vancomycin-resistant-enterococcus-faecalis-in-children-an-alarming-concern
#15
F Sabouni, Z Movahedi, S Mahmoudi, B Pourakbari, S Keshavarz Valian, S Mamishi
INTRODUCTION: Enterococcus spp. is considered as important etiological agents of nosocomial infections. However, a little is known about the epidemiology of vancomycin resistant Enterococcus faecalis (VREF). The aim of this study was to investigate the frequency of VREF and detecting of two prevalent resistance genes (vanA, vanB) at Children Medical Center Hospital, an Iranian referral pediatric Hospital. MATERIALS AND METHODS: During January 2013 to December 2013, 180 E...
December 2016: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28165526/ceftolozane-tazobactam-activity-against-drug-resistant-enterobacteriaceae-and-pseudomonas-aeruginosa-causing-urinary-tract-and-intraabdominal-infections-in-europe-report-from-an-antimicrobial-surveillance-programme-2012-15
#16
Michael A Pfaller, Matteo Bassetti, Leonard R Duncan, Mariana Castanheira
No abstract text is available yet for this article.
February 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28161293/molecular-epidemiology-of-carbapenemase-producing-enterobacteriaceae-in-a-primary-care-hospital-in-japan-2010-2013
#17
Yuki Ohno, Akihiro Nakamura, Eriko Hashimoto, Hiroko Matsutani, Noriyuki Abe, Saori Fukuda, Kohno Hisashi, Masaru Komatsu, Fumihiko Nakamura
Recently, carbapenemase-producing Enterobacteriaceae (CPE) have been spreading worldwide and have become a threat in healthcare systems. We investigated the isolation frequency and molecular epidemiological characteristics of CPE isolated from clinical samples collected at a primary care hospital over the four years of 2010-2013 in Japan. CPE were detected in 17 (0.34%) of 4875 isolates by the broth microdilution method, sodium mercaptoacetate inhibition test, and modified Hodge test using meropenem disks. The frequency of CPE isolates was 0...
February 1, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28156210/simultaneous-determination-of-clavulanic-acid-and-tazobactam-in-bovine-milk-by-hplc
#18
Peipei Guo, Yuan Chen, Chonghui Yue, Guoping Yu
A rapid and specific high-performance liquid chromatographic method was developed and validated for the simultaneous determination of the β-lactamase inhibitors clavulanic acid and tazobactam in bovine milk. The HPLC system was equipped with ultraviolet absorption detection using a C18 column with a detection wavelength of 215 nm. The mobile phase (pH 4) was 0.02% phosphoric acid and methanol in the ratio of 90:10 v/v. The retention times were 5.67 min for clavulanic acid and 7.22 min for tazobactam. The method exhibited good linearity for clavulanic acid and tazobactam, with R(2) > 0...
February 3, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28149487/clinical-response-and-outcome-of-pneumonia-due-to-multi-drug-resistant-acinetobacter-baumannii-in-critically-ill-patients
#19
Lida Shojaei, Mostafa Mohammadi, Mohammad-Taghi Beigmohammadi, Mahsa Doomanlou, Alireza Abdollahi, Mohammad Mehdi Feizabadi, Hossein Khalili
BACKGROUND AND OBJECTIVES: The frequency of multi-drug resistant Acinetobacter spp. infections is increasing in Iran. Considering availability of limited therapeutic options, clinical response and outcome of ventilator-associated pneumonia due to multi-drug resistant A.baumannii were evaluated in critically ill patients. MATERIALS AND METHODS: In this prospective study, 29 patients with carbapenem resistance A. baumannii ventilator-associated pneumonia were enrolled...
October 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28148226/trends-in-antimicrobial-resistance-and-empiric-antibiotic-therapy-of-bloodstream-infections-at-a-general-hospital-in-mid-norway-a-prospective-observational-study
#20
Arne Mehl, Bjørn Olav Åsvold, Angela Kümmel, Stian Lydersen, Julie Paulsen, Ingvild Haugan, Erik Solligård, Jan Kristian Damås, Stig Harthug, Tom-Harald Edna
BACKGROUND: The occurrence of bloodstream infection (BSI) and antimicrobial resistance have been increasing in many countries. We studied trends in antimicrobial resistance and empiric antibiotic therapy at a medium-sized general hospital in Mid-Norway. METHODS: Between 2002 and 2013, 1995 prospectively recorded episodes of BSI in 1719 patients aged 16-99 years were included. We analyzed the antimicrobial non-susceptibility according to place of acquisition, site of infection, microbe group, and time period...
February 2, 2017: BMC Infectious Diseases
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