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Chronic urticaria

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https://www.readbyqxmd.com/read/29165650/evaluation-of-1-25-dihydroxyvitamin-d3-pathway-in-patients-with-chronic-urticaria
#1
Rasoul Nasiri-Kalmarzi, Mohammad Abdi, Javad Hosseini, Erfan Babaei, Aram Mokarizadeh, Zakaria Vahabzadeh
BACKGROUND: Previous studies showed the role of vitamin D (Vit D) on the progression of chronic urticaria. To the best of our knowledge, there are no other results regarding the contribution of single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) genes in Chronic Urticaria (CU). AIM: In the present study, we investigated the Vit pathway and the association between VDR and VDBP gene polymorphisms and CU risk in Iranian population...
November 20, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29164723/double-blind-placebo-controlled-trial-of-the-effect-of-omalizumab-on-basophils-in-chronic-urticaria-patients
#2
Lukas Jörg, Tatjana Pecaric-Petkovic, Stephan Reichenbach, Michael Coslovsky, Odile Stalder, Werner Pichler, Oliver Hausmann
BACKGROUND: Omalizumab has been shown to be effective in treating chronic spontaneous urticaria (CSU). The reduction of FcεRI receptor density on the surface of basophils and mast cells is thought to play a major role in its effectiveness. We conducted a double-blind, randomized, placebo-controlled trial to investigate the mode of action of omalizumab in patients with antihistamine-resistant CSU. METHODS: Thirty patients were randomized in a 2:1 ratio to receive either 300 mg omalizumab or placebo...
November 22, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29158868/prevalence-of-papular-urticaria-caused-by-flea-bites-and-associated-factors-in-children-1-6%C3%A2-years-of-age-in-bogot%C3%A3-d-c
#3
Evelyne Halpert, Elizabeth Borrero, Milciades Ibañez-Pinilla, Pablo Chaparro, Jorge Molina, Maritza Torres, Elizabeth García
Background: Papular urticaria is a chronic inflammatory disease caused by exposure to arthropod bites. The disease has been reported in children attending medical centers, but the causes as the risk factors associated with the disease have not been established. The objective of this study was to determine the prevalence of papular urticaria caused by flea bite and identify the risk factors in children between 1 to 6 years of age in Bogotá D.C, between March 2009 and June 2011. Methods: A cross-sectional, two-stage, clustered study using random probability sampling and stratified with proportional allocation was carried out in children (1-6 years of age) in educational institutions in Bogotá D...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/29157861/hydroxychloroquine-as-a-steroid-sparing-agent-in-an-infant-with-chronic-urticaria
#4
Onyinye I Iweala, Christopher Copenhaver, Eveline Y Wu, Timothy P Moran
No abstract text is available yet for this article.
November 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29150066/treatment-with-omalizumab-or-cyclosporine-for-resistant-chronic-spontaneous-urticaria
#5
Renee Koski, Katelin K Kennedy
No abstract text is available yet for this article.
November 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29132956/the-xtend-ciu-study-long-term-use-of-omalizumab-in-chronic-idiopathic-urticaria
#6
Marcus Maurer, Allen Kaplan, Karin Rosén, Michael Holden, Ahmar Iqbal, Benjamin L Trzaskoma, Ming Yang, Thomas B Casale
These data support omalizumab safety and efficacy in patients with antihistamine-resistant CIU/CSU to 48 weeks and provide evidence of omalizumab re-treatment efficacy and safety.
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29131099/the-prevalence-of-periodontitis-is-increased-in-psoriasis-and-linked-to-its-inverse-subtype
#7
Clemens Painsi, Alexander Hirtenfelder, Bernhard Lange-Asschenfeldt, Franz Quehenberger, Peter Wolf
Periodontitis and psoriasis are suggested to be co-occurring, chronic inflammatory conditions with overlapping characteristics. However, respective evidence is rare and data on risk factors of periodontitis in psoriasis patients are minimal. The aim of this study was to expand the evidence of psoriasis-associated periodontitis and establish a potential risk profile for periodontitis. In total, data from 209 exacerbated psoriasis patients were retrospectively analyzed on recordings of periodontitis and compared with those of 91 patients with chronic spontaneous urticaria (CSU)...
November 2, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29130488/crp-is-linked-to-disease-activity-impact-and-response-to-treatment-in-patients-with-chronic-spontaneous-urticaria
#8
Pavel Kolkhir, Sabine Altrichter, Tomasz Hawro, Marcus Maurer
BACKGROUND: Elevated levels of C-reactive protein (CRP), a sensitive marker of inflammation, have been consistently reported in chronic spontaneous urticaria. Here, we retrospectively analyzed data from 1,253 CSU patients from two centers to answer the following questions: 1) What is the prevalence of elevated levels of CRP in CSU? 2) Why do CSU patients show elevated levels of CRP? 3) Are elevated CRP levels relevant? METHODS: Serum levels of CRP were measured by the nephelometric method...
November 12, 2017: Allergy
https://www.readbyqxmd.com/read/29129806/treatment-of-chronic-spontaneous-urticaria-immunomodulatory-approaches
#9
REVIEW
de Montjoye Laurence, Herman Anne, Nicolas Jean-François, Baeck Marie
This paper summarizes and reviews the mechanisms of action and data concerning efficacy of recommended treatments as well as other treatments that have been tested, independently of the outcomes, in the management of chronic spontaneous urticaria. Due to the central role of mast cells and histamine in the pathophysiology of this disease, H1-antihistamines remain the first-line treatment. However, current knowledge about this complex disease, also recognizes an important role for T lymphocytes, B lymphocytes, and autoantibodies...
November 9, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29128337/the-urticaria-activity-score-validity-reliability-and-responsiveness
#10
Tomasz Hawro, Tatevik Ohanyan, Nicole Schoepke, Martin Metz, Adriane Peveling-Oberhag, Petra Staubach, Marcus Maurer, Karsten Weller
BACKGROUND: Chronic spontaneous urticaria is characterized by fluctuating symptoms. Its activity is assessed with the urticaria activity score (UAS). Two versions of the urticaria activity score used for 7 consecutive days (UAS7) are available: (1) The guideline-recommended UAS7, with once-daily documentation, and (2) the UAS7TD, with twice-daily documentation. OBJECTIVE: To better characterize both UAS7 versions with regard to their validity, reliability, sensitivity to change, minimal important difference (MID), and smallest detectable change (SDC)...
November 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29119197/-correction-chronic-urticaria-in-childhood-rational-diagnostics-and-treatment
#11
H Ott
No abstract text is available yet for this article.
November 8, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29111302/-cryopyrin-associated-periodic-syndromes
#12
P Quartier, F Rodrigues, S Georgin-Lavialle
Cryopyrin-associated periodic syndromes (CAPS) are linked to one single gene mutations, however they are associated with 3 syndromes, which are, from the mildest to the most severe phenotype familial cold urticaria, Muckle-Wells syndrome and chronic, infantile, neurologic, cutaneous, articular (CINCA) syndrome also called neonatal-onset multisystem inflammatory disease (NOMID). Autosomic dominant inheritance is present in most cases but in CINCA/NOMID syndrome where neomutations are more common. Mutations in the gene encoding cryopyrin, NLRP3, are associated with deregulation of caspase-1 activity, excessive interleukin-1 production and an autoinflammatory syndrome, which in familial cold urticaria and Muckle-Wells syndrome may be triggered or worsened by exposure to coldness...
October 27, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29108771/biologics-in-chronic-urticaria
#13
REVIEW
M Ferrer, R Madamba
No abstract text is available yet for this article.
November 3, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29102514/efficacy-and-safety-of-omalizumab-for-the-treatment-of-refractory-chronic-spontaneous-urticaria-in-japanese-patients-subgroup-analysis-of-the-phase-3-polaris-study
#14
Michihiro Hide, Atsuyuki Igarashi, Akiko Yagami, Yuko Chinuki, Naoko Inomata, Atsushi Fukunaga, Guenther Kaiser, Junyi Wang, Soichiro Matsushima, Steven Greenberg, Sam Khalil
BACKGROUND: Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H1 antihistamines (H1AH) in the POLARIS study (NCT02329223), a randomized, double-blind, placebo-controlled trial in East Asian patients. However, data in Japanese patients, who have specific baseline characteristics (e.g., low angioedema incidence, different background medications) that may impact clinical outcomes, are lacking...
November 1, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29083482/the-clinical-response-to-omalizumab-in-csu-patients-is-linked-to-and-predicted-by-ige-levels-and-their-change
#15
Ragip Ertas, Kemal Ozyurt, Mustafa Atasoy, Tomasz Hawro, Marcus Maurer
BACKGROUND: Omalizumab is an effective and well-tolerated treatment for chronic spontaneous urticaria (CSU). Markers and predictors of response are largely unknown, but needed to optimize omalizumab treatment. Omalizumab targets IgE, and IgE levels may be linked to the effects of treatment. We evaluated if response rates to treatment with omalizumab in patients with CSU are linked to their baseline IgE levels, their IgE levels after omalizumab treatment, and the ratio of on treatment IgE and baseline IgE levels...
October 30, 2017: Allergy
https://www.readbyqxmd.com/read/29064325/real-world-treatment-patterns-and-outcomes-of-omalizumab-use-in-patients-with-chronic-idiopathic-urticaria
#16
Liya Wang, Xuehua Ke, Abhishek Kavati, Debra Wertz, Qing Huang, Vincent J Willey, Judith J Stephenson, Benjamin Ortiz, Brandee Paknis, Jonathan A Bernstein, Lisa A Beck
OBJECTIVE: To examine treatment patterns, treatment response, and demographic and clinical characteristics of patients with chronic idiopathic urticaria (CIU) newly initiated on omalizumab therapy in real-world practice in the US. METHODS: This retrospective observational cohort study used US claims data from the HealthCore Integrated Research Database (HIRD(®)) augmented with medical record data to identify CIU patients newly-treated with omalizumab (≥4 omalizumab claims within 6 months of initial claim; index date = first omalizumab claim date) between March 21, 2014 and October 31, 2015 and with ≥6 months pre- and ≥12 months post-index health plan eligibility...
November 10, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29064119/in-chronic-spontaneous-urticaria-high-numbers-of-dermal-endothelial-cells-but-not-mast-cells-are-linked-to-recurrent-angio-oedema
#17
D Terhorst, I Koti, K Krause, M Metz, M Maurer
BACKGROUND: Chronic spontaneous urticaria (CSU) is an inflammatory skin disorder characterized by recurrent weals, angio-oedema or both. Recent studies have shown that the number of endothelial cells is increased in the skin of patients with CSU, but the underlying mechanisms and clinical implications of this are unclear. AIM: To evaluate whether mast cell (MC) or endothelial cell (EC) numbers correlate with CSU and whether they are relevant for disease duration, disease activity or the presence of clinical features...
October 24, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29059195/strongyloides-stercoralis-is-associated-with-significant-morbidity-in-rural-cambodia-including-stunting-in-children
#18
Armelle Forrer, Virak Khieu, Fabian Schär, Jan Hattendorf, Hanspeter Marti, Andreas Neumayr, Meng Chuor Char, Christoph Hatz, Sinuon Muth, Peter Odermatt
BACKGROUND: Strongyloides stercoralis is a soil-transmitted nematode that can replicate within its host, leading to long-lasting and potentially fatal infections. It is ubiquitous and highly prevalent in Cambodia. The extent of morbidity associated with S. stercoralis infection is difficult to assess due to the broad spectrum of symptoms and, thus, remains uncertain. METHODOLOGY/PRINCIPAL FINDINGS: Clinical signs were compared among S. stercoralis infected vs. non-infected participants in a cross-sectional survey conducted in 2012 in eight villages of Northern Cambodia, and before and after treatment with a single oral dose of ivermectin (200μg/kg BW) among participants harboring S...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29058822/omalizumab-rapidly-improves-angioedema-related-quality-of-life-in-adult-patients-with-chronic-spontaneous-urticaria-x-act-study-data
#19
Petra Staubach, Martin Metz, Nadine Chapman-Rothe, Christian Sieder, Matthias Bräutigam, Marcus Maurer, Karsten Weller
BACKGROUND: The X-ACT study aims to examine the effect of omalizumab treatment on quality of life (QoL) in chronic spontaneous urticaria (CSU) patients with angioedema refractory to high doses of H1 -antihistamines. METHODS: In X-ACT, a phase III, double-blind, placebo-controlled study, CSU patients (18-75 years) with ≥4 angioedema episodes during the 6 months before inclusion were randomized (1:1) to receive omalizumab 300 mg or placebo every 4 weeks for 28 weeks...
October 23, 2017: Allergy
https://www.readbyqxmd.com/read/29058325/itching-for-nail-fashion-chronic-urticaria-and-chronic-hand-dermatitis-secondary-to-acrylate-and-methacrylate-allergy-in-gel-nail-varnish
#20
P Dickison, S D Smith
Allergic contact dermatitis (ACD) secondary to acrylates and methacrylates is a well- described occurrence, particularly in those who wear or handle gel nail varnish. Management involves avoidance of the identified allergen. The cause of chronic urticaria (CI) is often not identified, and CU is not known to be associated with acrylates or methacrylates. We report a case of a 50-year-old woman who initially presented with hand dermatitis exacerbated by gel nail varnish on a background of CU. Avoiding all nail varnishes because of her ACD also resulted in improvement of her CU...
October 23, 2017: Clinical and Experimental Dermatology
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