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Chronic urticaria

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https://www.readbyqxmd.com/read/29779967/a-comparison-of-the-united-states-and-international-perspective-on-chronic-urticaria-guidelines
#1
REVIEW
Torsten Zuberbier, Jonathan A Bernstein
Urticaria is a heterogeneous skin disorder that may be acute or chronic and is defined by the appearance of wheals, angioedema, or both. The European perspective is expressed in a recent international guideline and the American perspective has been based on the US Joint Task Force chronic urticaria practice parameter published in 2014. Both the international guideline (initiated by the European societies European Academy of Allergology and Clinical Immunology [EAACI]/Global Allergy and Asthma European Network [GA2 LEN]/European Dermatology Forum [EDF] in collaboration with the World Allergy Organization [WAO]) and the US (American Academy of Allergy, Asthma & Immunology/American College of Allergy, Asthma and Immunology) guideline have been developed to help direct primary care physicians and specialists in the management of their patients with urticaria...
May 18, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29772036/chronic-urticaria-following-practice-guidelines
#2
E P Westby, C Lynde, G Sussman
Histamine is a key inflammatory player in the pathogenesis of urticaria, a mast-cell-driven disease characterized clinically by the development of wheals, angioedema, or both. Changes to the management of chronic spontaneous urticaria have recently been adopted due to increasing literature surrounding the efficacy and safety of up-dosing modern second-generation H1 -antihistamines and the use of omalizamub, a biologic agent, as a third-line treatment. Given the prevalence of chronic urticaria and its impact on quality of life, this editorial aims to provide a summary of the proposed updated guidelines for the management of chronic urticaria as agreed upon at the 5th Consensus Conference on the Update and Revision of the EAACI/GA2 LEN/EDF/WAO Guideline for Urticaria in Berlin in December 2016...
May 2018: Skin Therapy Letter
https://www.readbyqxmd.com/read/29770909/omalizumab-in-chronic-spontaneous-urticaria-refractory-to-conventional-therapy-an-italian-retrospective-clinical-analysis-with-suggestions-for-long-term-maintenance-strategies
#3
Victor D Mandel, Mario B Guanti, Serena Liberati, Antongiulio Demonte, Giovanni Pellacani, Patrizia Pepe
INTRODUCTION: Omalizumab is indicated for the treatment of patients affected by chronic spontaneous urticaria (CSU) refractory to antihistamines. The aim of this study was to assess the efficacy, safety, and recurrence of symptoms in a real-life experience of omalizumab as an add-on therapy for H1 -antihistamine-refractory CSU patients (refractory CSU). METHODS: A retrospective review of the clinical records of all refractory CSU treated with omalizumab at our dermatology center from June 2014 to April 2017 was performed...
May 16, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29769469/-activation-mechanisms-of-mast-cells-in-chronic-spontaneous-urticaria
#4
Yoshimichi Okayama
No abstract text is available yet for this article.
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29760615/stress-itch-and-quality-of-life-in-chronic-urticaria-females
#5
Alicja Ograczyk-Piotrowska, Zofia Gerlicz-Kowalczuk, Anna Pietrzak, Anna M Zalewska-Janowska
Introduction: Chronic urticaria (CU) belongs to a group of psychodermatological disorders, thus stress can play a significant role in this dermatosis onset and/or exacerbation. On the other hand, the disease itself accompanied by itch, may be a source of distress and could worsen patients' quality of life (QoL). Aim: The first goal of our study was to compare stress intensity between CU subjects and the control group. The second aim was to investigate the relationships between disease-related parameters (CU severity, itch) and psychological variables (stress and QoL) in CU patients...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29760614/eradication-of-helicobacter-pylori-as-add-on-therapy-has-a-significant-but-temporary-influence-on-recovery-in-chronic-idiopathic-urticaria-a-placebo-controlled-double-blind-trial-in-the-polish-population
#6
Robert Pawłowicz, Krzysztof Wytrychowski, Bernard Panaszek
Introduction: The infectious factor like Helicobacter pylori (HP) has been thought to trigger the vicious circle of chronic idiopathic urticaria (CIU), therefore its eradication could modify the course of the disease. Aim: To reveal the influence of HP eradication on CIU clinical course. Material and methods: Sixty-four CIU patients, receiving fexofenadine, as the basic treatment, took part in the research, divided into 3 groups: HP patients treated by eradication, HP patients receiving placebo, and patients without bacteria...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29757034/educational-level-and-job-status-are-the-most-important-factors-affecting-compliance-to-oral-antihistamine-therapy-for-patients-with-chronic-urticaria
#7
Neslihan Akdogan, Pinar Incel-Uysal, Ayşe Oktem, Yildiz Hayran, Basak Yalcin
BACKGROUND: Management of chronic urticaria (CU) is often difficult with oral antihistamines (OAs) despite long-term use. OBJECTIVE: The aim of this study was to determine the extent of medication compliance (MC) and to assess the factors affecting the MC of CU patients toward OA therapy. METHODS: A 43-item questionnaire was administered to 201 adult patients. A compliance score (CS) of 6 points was chosen as a cut-off point. A CS of 0─6 correspond to poor compliance and scores of 6─9, to good compliance...
May 14, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29751088/integrated-behavioral-health-care-for-management-of-stress-in-allergic-diseases
#8
REVIEW
Alyssa Oland, Genery D Booster, Bruce G Bender
OBJECTIVE: The present article will review current findings regarding the management of stress in allergic disease. DATA SOURCES: The present review article uses articles and books published between 1995 and 2017. Approximately 85% of sources used were published in the last 10 years and 60% were published in the last 5 years. The majority of sources are peer-reviewed articles. STUDY SELECTIONS: Articles that focused on allergic diseases such as allergic rhinitis, food allergies, urticaria, and allergic asthma were included in the present review...
May 8, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29750467/chronic-urticaria-what-does-the-new-guideline-tell-us
#9
Marcus Maurer, Torsten Zuberbier, Frank Siebenhaar, Karoline Krause
Patients with chronic urticaria experience significant impairment, and require an effective treatment. Such treatment is preceded by a thorough diagnostic workup and measurement of disease activity, disease burden and disease control using well--established tools. Treatment is subsequently adjusted according to patient needs and therapeutic response, based on the tenet "as much as necessary, as little as possible" (in that order). Once disease control has been achieved, it is recommended that intermittent attempts at medication withdrawal be made in order to identify spontaneous disease remission...
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29734181/which-fruits-and-vegetables-should-be-excluded-from-a-low-salicylate-diet-an-analysis-of-salicylic-acid-in-foodstuffs-in-taiwan
#10
Hui-Ling Chiang, Carina Venter, Pai-Chi Syue, Kuo-Lung Ku, Cheng-Han Wu
BACKGROUND: Eliminating pseudoallergens is an important element of managing chronic spontaneous urticaria (CSU). Salicylic acid (SA) is a primary pseudoallergen in plant-based foodstuffs. Current dietary recommendations are not applicable in East Asia because data on the SA content of many vegetables and fruits commonly consumed in this region are lacking. METHODS: We therefore determined the concentration of free SA in 79 popular vegetables and fruits frequently consumed in Taiwan using gas chromatography-mass spectrometry...
May 7, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29733981/montelukast-reduces-symptom-severity-and-frequency-in-patients-with-angioedema-predominant-chronic-spontaneous-urticaria
#11
Ayobami T Akenroye, Conor McEwan, Sarbjit S Saini
No abstract text is available yet for this article.
May 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29732293/skin-prick-test-reactivity-to-aeroallergens-in-adult-allergy-clinic-in-thailand-a-12-year-retrospective-study
#12
Supa Oncham, Umaporn Udomsubpayakul, Wannada Laisuan
Background: The global prevalence of allergic rhinitis, asthma, and atopic dermatitis has risen significantly over the last 2 decades. Allergic sensitization to aeroallergen is a major risk factor in developing the allergic disease. The prevalence of aeroallergen sensitization varies in different regions and countries. Objective: To determine the prevalence of common aeroallergen sensitization and the atopic status among adult patients. Methods: A cross-sectional, retrospective study...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29729103/effectiveness-of-omalizumab-in-chronic-spontaneous-urticaria-assessed-with-patient-reported-outcomes-a-prospective-study
#13
Misbah Noshela Ghazanfar, Jesper Grønlund Holm, Simon Francis Thomsen
AIM: To examine the effectiveness of omalizumab (anti-IgE) on symptoms and disease-related quality of life in chronic spontaneous urticaria (CSU), and to identify possible patient specific factors associated with response to omalizumab in patients with antihistamine refractory CSU. METHODS: Six months prospective trial of omalizumab 300 mg every four weeks among patients with CSU from a dermatological university department. The primary outcome was the urticaria activity score in the past week (UAS7) at three months...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29707401/a-rare-but-fascinating-disorder-case-collection-of-patients-with-schnitzler-syndrome
#14
Maaman Bashir, Brittany Bettendorf, Richard Hariman
Background: Schnitzler syndrome is a rare disorder characterized by a chronic urticarial rash and monoclonal gammopathy (IgM in more than 90% of the cases). It is difficult to distinguish from other neutrophilic urticarial dermatoses, and diagnosis is based on the Strasbourg criteria. Interleukin-1 is considered the key mediator, and interleukin-1 inhibitors are considered first line treatment. Here, we present two cases of Schnitzler syndrome, both successfully treated with anakinra...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29702735/effects-of-ugt1a1-cyp3a5-and-abcb1-genetic-variants-on-pharmacokinetics-of-antihistamine-drug-mizolastine-in-chinese-healthy-volunteers
#15
Pu Li, Min-Ji Wei, Zhi-Yuan Zhang, Sheng-Ju Yin, Xin Wang, Ya-Qing Lou, Zi-Sheng Kang, Yuan Lu, Xuan Wei, Suo-Di Zhai, Guo-Liang Zhang
Mizolastine is a selective histamine H1 receptor antagonist for chronic urticaria or allergic rhinitis. We investigated whether the variant genotypes of metabolic enzymes UGT1A1, CYP3A5 and transporter ABCB1 influence pharmacokinetic phenotype of substrate mizolastine in Chinese volunteers. Genotyping of single nucleotide polymorphisms (SNPs) in UGT1A1*6 (G211A), CYP3A5*3 (A6986G) and ABCB1 (C3435T) were determined by the pyrosequencing method. After a single oral dose of 10 mg mizolastine, the plasma concentrations were measured using validated high performance liquid chromatography (HPLC) in 24 Chinese healthy volunteers...
April 27, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29698966/diamine-oxidase-supplementation-in-chronic-spontaneous-urticaria-a-randomized-double-blind-placebo-controlled-study
#16
Mona-Rita Yacoub, Giuseppe A Ramirez, Alvise Berti, Giuseppe Mercurio, Daniela Breda, Nicoletta Saporiti, Samuele Burastero, Lorenzo Dagna, Giselda Colombo
INTRODUCTION: Diamine oxidase (DAO) catabolizes and inactivates histamine, a key player in a wide range of invalidating conditions, such as migraine and chronic spontaneous urticaria (CSU). The highest expression of DAO occurs in the gastrointestinal tract, possibly to control the burden of histamine intake from food. METHODS: Here, we tested the hypothesis that a 30-day oral supplementation with DAO (1 capsule b.i.d., 15 min before a meal) could reduce the severity of CSU as estimated by the 7-Day Urticaria Activity Score (UAS-7)...
April 26, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29694255/serum-prolactin-level-in-chronic-urticaria-is-promocriptine-inducing-remission-in-chronic-urticaria
#17
Mohamed Soliman, Fathia M Khattab, Mohamad Nasr
BACKGROUND: Chronic urticaria (CU) is a disturbing disease with a negative impact on quality of life. Despite of several clinical studies on CU patients, its pathogenesis is poorly understood. Prolactin (PRL) is peptide hormone has immunomodulatory effects in some immune inflammatory skin diseases. AIM: To elucidate any possible relationship between the immunomodulatory effects of Prolactin (PRL) and CU. Besides, the study aims to investigate the crucial role of antiprolactin drugs in the management of CU patients...
April 25, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29693079/schnitzler-syndrome-associated-with-hairy-cell-leukemia-presenting-with-chronic-urticaria-and-arthralgias
#18
Hélène Fank, Jo Caers, Michel Lambert, Liliane Marot, Laurence De Montjoye, Dominique Tennstedt, Marie Baeck, Valérie Dekeuleneer
No abstract text is available yet for this article.
May 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29686678/immunoglobulin-e-mediated-autoimmunity
#19
REVIEW
Marcus Maurer, Sabine Altrichter, Oliver Schmetzer, Jörg Scheffel, Martin K Church, Martin Metz
The study of autoimmunity mediated by immunoglobulin E (IgE) autoantibodies, which may be termed autoallergy, is in its infancy. It is now recognized that systemic lupus erythematosus, bullous pemphigoid (BP), and chronic urticaria, both spontaneous and inducible, are most likely to be mediated, at least in part, by IgE autoantibodies. The situation in other conditions, such as autoimmune uveitis, rheumatoid arthritis, hyperthyroid Graves' disease, autoimmune pancreatitis, and even asthma, is far less clear but evidence for autoallergy is accumulating...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29682366/whole-exome-sequencing-and-molecular-modeling-of-a-missense-variant-in-tnfaip3-that-segregates-with-disease-in-a-family-with-chronic-urticaria-and-angioedema
#20
Antoneicka L Harris, Patrick R Blackburn, John E Richter, Jennifer M Gass, Thomas R Caulfield, Ahmed N Mohammad, Paldeep S Atwal
Chronic urticaria is a common condition characterized by recurrent hives lasting several weeks or months and is usually idiopathic. Approximately half of the individuals with chronic urticaria will present with episodes of angioedema that can be severe and debilitating. In this report, we describe a 47-year-old Hispanic male who presented initially for an evaluation of chronic hives following hospitalization due to hive-induced anaphylaxis. The individual had a history significant for urticaria and angioedema beginning in his early 30s...
2018: Case Reports in Genetics
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