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Chronic urticaria

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https://www.readbyqxmd.com/read/28924988/benefit-from-reslizumab-treatment-in-a-patient-with-chronic-spontaneous-urticaria-and-cold-urticaria
#1
Marcus Maurer, Sabine Altrichter, Martin Metz, Torsten Zuberbier, Martin K Church, Karl-Christian Bergmann
Chronic urticaria (CU) is a group of common and debilitating conditions containing both chronic spontaneous urticaria (CSU) and chronic inducible urticarias (CIndU) including cold urticaria (ColdU) [1]. While antihistamines and omalizumab are effective treatments for both CSU and ColdU [2], many patients show insufficient response to either or both of these treatments [3], and additional and better therapies are needed [4]. This article is protected by copyright. All rights reserved.
September 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28916431/cyclosporine-for-chronic-spontaneous-urticaria-a-meta-analysis-and-systematic-review
#2
Kanokvalai Kulthanan, Pichanee Chaweekulrat, Chulaluk Komoltri, Saowalak Hunnangkul, Papapit Tuchinda, Leena Chularojanamontri, Marcus Maurer
BACKGROUND: Despite widely recommended usage of cyclosporine A (CsA) in chronic spontaneous urticaria (CSU), there is no meta-analysis concerning its efficacy and safety. OBJECTIVE: To meta-analyze and review the efficacy and safety of CsA in CSU. METHODS: Efficacy was assessed by the relative change in urticaria activity score at 4 weeks and response rates at 4, 8, and 12 weeks. Safety was assessed by analyzing the number of patients with 1 or more adverse event...
September 12, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28913986/chronic-spontaneous-urticaria-pathogenesis-and-treatment-considerations
#3
REVIEW
Allen P Kaplan
The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H₁-receptor blockers are typically employed up to 4 times a day. First-generation antihistamines, such as hydroxyzine or diphenhydramine (Atarax or Benadryl), were employed similarly in the past. Should high-dose antihistamines fail to control symptoms (at least 50%), omalizumab at 300 mg/month is the next step...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28898460/burden-of-chronic-urticaria-relative-to-psoriasis-in-five-european-countries
#4
M M Balp, S Khalil, H Tian, S Gabriel, J Vietri, T Zuberbier
BACKGROUND: Quantification of burden of chronic spontaneous urticaria (CSU) versus psoriasis (PsO) is limited. OBJECTIVE: To evaluate the burden associated with CSU versus PsO of all severities (overall PsO), mild and moderate/severe PsO. METHODS: his retrospective cross-sectional analysis compared data from adult patients with chronic urticaria (CU), used as a proxy for CSU, and PsO from the National Health and Wellness Survey in France, Germany, Italy, Spain, and the United Kingdom...
September 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28888844/recurrence-of-chronic-urticaria-incidence-and-associated-factors
#5
Julie K Kim, Daniel Har, L Steven Brown, David A Khan
BACKGROUND: Chronic urticaria (CU) is urticaria that has been present continuously or intermittently for at least 6 weeks. Although the prevalence and characteristics of CU are well established, little is known about recurrent CU (RCU). OBJECTIVES: We sought to establish a definition, determine the frequency, and evaluate risk factors for RCU. METHODS: A retrospective chart review of adult patients with CU evaluated at the University of Texas Southwestern allergy and immunology clinic was performed...
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28884989/hydroxychloroquine-in-the-treatment-of-anti-histamine-refractory-chronic-spontaneous-urticaria-randomized-single-blinded-placebo-controlled-trial-and-an-open-label-comparison-study
#6
T Boonpiyathad, A Sangasapaviliya
Background. The management of anti-histamine refractory chronic spontaneous urticaria (CSU) has poorly defined therapeutic options. Some patients with CSU respond poorly to a fourfold increase in dosage of H1-anti-histamines treatment. Aim. The objective of this study was to determine the effect of an adjunct treatment of hydroxychloroquine (HCQ) on remission rate and reduction of urticarial symptoms. Methods. Sixty subjects with anti-histamine refractory CSU were randomly assigned to 400 mg of HCQ daily or placebo for 12 weeks in a single blind placebo controlled trial...
September 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28884987/the-link-between-chronic-spontaneous-urticaria-and-metabolic-syndrome
#7
G A Vena, N Cassano
Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and is considered a chronic low-level systemic inflammatory condition. Recent preliminary findings have shown an increased prevalence of MS among patients with chronic urticaria (CU) as compared to controls, with a particularly higher prevalence detected in patients with uncontrolled CU. Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with MS, including a pro-inflammatory state, increased oxidative stress, alterations in adipokine profile and activation of the coagulation system...
September 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28871952/-up-regulated-expression-of-nk1r-in-eosinophil-enriched-blood-cells-from-patients-with-chronic-spontaneous-urticaria
#8
Wei Wang, Huiyun Zhang, Wenjiao Zheng, Shaoheng He
Objective To investigate the expressions of substance P (SP) and neurokinin-1 receptor (NK1R) in eosinophil-enriched blood cells from patients with chronic spontaneous urticaria (CSU). Methods Peripheral venous blood samples were collected from patients with CSU and healthy controls (HCs), and then stimulated with crude extracts of Artemisia pollen, dust mite, and Platanus pollen (all at concentrations of 0.1 and 1.0 μg/mL). The expressions of SP and NK1R in eosinophil-enriched blood cells were detected by flow cytometry...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28870460/elevated-ige-levels-are-linked-to-faster-relapse-in-omalizumab-discontinued-chronic-spontaneous-urticaria-patients
#9
Ragip Ertas, Kemal Ozyurt, Emin Ozlu, Yilmaz Ulas, Atil Avci, Mustafa Atasoy, Tomasz Hawro, Marcus Maurer
No abstract text is available yet for this article.
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28865416/immunological-mechanisms-implicated-in-the-pathogenesis-of-chronic-urticaria-and-hashimoto-thyroiditis
#10
Nicolae Ovidiu Berghi
Autoimmunity represents the attack of the immune system of an organism against its own cells and tissues. Autoimmune diseases may affect one organ (Hashimoto thyroiditis) or can be systemic (chronic urticaria). Many factors are implicated in the pathogenesis of autoimmunity (white cells, cytokines, chemokines). Hashimoto thyroiditis has been associated with chronic urticaria in the last 3 decades in a number of clinical studies. Anti-thyroid antibodies have been documented in a proportion ranging from 10% to 30% in chronic urticaria patients in different countries from 3 continents...
August 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28858880/the-histopathology-of-urticaria-revisited-clinical-pathological-study
#11
Aviv Barzilai, Lior Sagi, Sharon Baum, Henri Trau, Michael Schvimer, Iris Barshack, Michal Solomon
BACKGROUND: The classic histopathological findings of urticaria include dermal edema and a sparse perivascular infiltrate of neutrophils, eosinophils, macrophages, and lymphocytes. However, this pattern is inconsistently described. OBJECTIVE: To describe the histological and immunofluorescence characteristics of urticaria and to identify distinctive patterns. METHODS: A retrospective study was performed in which the medical files and biopsy specimens of 58 patients with acute and chronic classical urticaria were reviewed...
October 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28853054/erratum-to-the-burden-of-chronic-urticaria-from-brazilian-patients-perspective
#12
Maria-Magdalena Balp, Nilcéia Lopes da Silva, Jeffrey Vietri, Haijun Tian, Luis F Ensina
No abstract text is available yet for this article.
August 29, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28852410/management-of-chronic-spontaneous-urticaria-csu-a-treat-to-target-approach-using-a-patient-reported-outcome
#13
Hermenio Lima, Melinda Gooderham, Jan Dutz, Charles Lynde, Hugo Chapdelaine, Anne Ellis, Martin Gilbert, Vincent Ho, Kim Papp, Yves Poulin, Gordon Sussman
BACKGROUND: Treat-to-target therapy approaches are established for chronic diseases such as diabetes, hypertension, and more recently rheumatoid arthritis, resulting in improved patient outcomes. These approaches do not use patient reported outcomes (PRO) as targets of therapy. Chronic spontaneous urticaria (CSU), also called chronic idiopathic urticaria (CIU), is defined as recurrent urticaria of known and unknown cause, lasting more than 6 weeks. Treatment of CSU can be challenging...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28846167/chronic-urticaria-and-the-metabolic-syndrome-a-cross-sectional-community-based-study-of-11-261-patients
#14
G Shalom, E Magen, M Babaev, S Tiosano, D A Vardy, D Linder, A Horev, A Saadia, D Comaneshter, N Agmon-Levin, A D Cohen
BACKGROUND: Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low grade, inflammatory process. OBJECTIVE: To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database. METHODS: A cross-sectional study of CU patients and matched controls was performed. CU was defined as eight urticaria diagnoses (with each two diagnoses registered within a period of six weeks) from 2002 to 2012...
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28846158/different-expression-patterns-of-plasma-th1-th2-th17-and-th22-related-cytokines-correlate-with-serum-autoreactivity-and-allergen-sensitivity-in-chronic-spontaneous-urticaria
#15
Qiquan Chen, Hua Zhong, WenChieh Chen, Zhifang Zhai, Zhou Zhou, Zhiqiang Song, Fei Hao
BACKGROUND: Clinical features and basophil activation levels correlate with serum autoreactivity and allergen sensitivity in patients with chronic spontaneous urticaria (CSU). OBJECTIVES: To explore the relationship of the expression patterns of plasma T-helper cell (Th) 1, Th2, Th17, and Th22-related cytokines with the serum autoreactivity and the allergen sensitivity in CSU. METHOD: Twenty related cytokines were measured and analysed in 60 CSU patients, 15 acute urticaria patients, 10 patients with atopic dermatitis (AD), and 15 healthy persons, respectively...
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28827590/omalizumab-efficacy-in-cases-of-chronic-spontaneous-urticaria-is-not-explained-by-the-inhibition-of-sera-activity-in-effector-cells
#16
Eva Serrano-Candelas, Rubén Martínez-Aranguren, Olga Vega, Gabriel Gastaminza, Joan Bartra, Maria Teresa Audicana, Jorge M Núñez-Córdoba, Jaime Algorta, Antonio Valero, Margarita Martin, Marta Ferrer
Omalizumab (OmAb) is a humanized anti-IgE antibody approved for the treatment of chronic spontaneous urticaria (CSU). OmAb's mechanism of action is known to include actions on free IgE and on pre-bound IgE. However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria where IgE involvement is not clear, suggesting the involvement of additional mechanisms of action. In this study, we sought to investigate the ability of OmAb to inhibit mast cell and basophil degranulation induced by sera from CSU patients...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819778/impact-of-jumihaidokuto-shi-wei-bai-du-tang-on-treatment-of-chronic-spontaneous-urticaria-a-randomized-controlled-study
#17
Hiroyuki Murota, Hiroaki Azukizawa, Ichiro Katayama
OBJECTIVE: To study the effect of Jumihaidokuto (Shi-Wei-Bai-Du-Tang, ) in the management of chronic spontaneous urticaria. METHODS: A randomized two-arm, parallel group study was conducted to compare the effect of Jumihaidokuto (6 g daily) with a control for 8 weeks. Concomitant therapy (e.g., antihistamines) was continued. Twenty-one subjects with severe chronic urticaria were enrolled in this study. The primary treatment outcome was the severity score proposed by the Japanese Dermatological Association...
August 17, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28815631/comparison-and-interpretability-of-the-available-urticaria-activity-scores
#18
T Hawro, T Ohanyan, N Schoepke, M Metz, A Peveling-Oberhag, P Staubach, M Maurer, K Weller
The urticaria activity score (UAS) is the gold standard for assessing disease activity in patients with chronic spontaneous urticaria (CSU). Two different versions, the UAS7 and UAS7TD , are currently used in clinical trials and routine care. To compare both versions and to obtain data on their interpretability, 130 CSU patients applied both versions and globally rated their disease activity as none, mild, moderate, or severe. UAS7 and UAS7TD values correlated strongly (r=0.90, P<0.001). Interquartile ranges for UAS7 and UAS7TD values for mild, moderate and severe CSU were 11-20 and 10-24, 16-30 and 16-32, and 27-37 and 28-40...
August 16, 2017: Allergy
https://www.readbyqxmd.com/read/28803183/chronic-urticaria-patient-perspective-cupp-the-first-validated-tool-for-assessing-quality-of-life-in-clinical-practice
#19
Ilaria Baiardini, Fulvio Braido, Giorgia Molinengo, Marco Caminati, MariaTeresa Costantino, Antonio Cristaudo, Mariangiola Crivellaro, Silvia Mariel Ferrucci, Rosella Gallo, Veronica Giorgis, Agostina Legori, Barbara Loera, Irene Martignago, Angelo Valerio Marzano, Aldo Morrone, Roberta Parente, Aurora Parodi, Anna Parolo, Silvia Peveri, Paolo Pigatto, Anna Radice, Erminia Ridolo, Giovanni Rolla, Chiara Roncallo, Oliviero Rossi, Eleonora Savi, Gianenrico Senna, Massimo Triggiani, Giorgio Walter Canonica
BACKGROUND: There is a need for validated tools to assess health-related quality of life (HRQoL) in routine clinical practice. OBJECTIVE: The aim of this study was to validate the Chronic Urticaria Patient Perspective (CUPP) for assessment of patients with chronic urticaria (CU) in clinical practice. METHODS: A provisional CUPP was developed from candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires...
August 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28780897/skin-diseases-of-the-vulva-eczematous-diseases-and-contact-urticaria
#20
Freja Lærke Sand, Simon Francis Thomsen
Skin diseases in the vulvar area include a variety of disorders many of which have a chronic course with significant morbidity. It is important to be aware of the symptoms, signs and diagnostic tools in order to optimise treatment. Herein, the most common eczematous diseases of the vulvar area, i.e. lichen simplex chronicus, seborrhoeic dermatitis, atopic dermatitis, irritant contact dermatitis, and non-systemic and systemic allergic contact dermatitis are reviewed. Allergic contact urticaria is also described...
August 7, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
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