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https://www.readbyqxmd.com/read/26263298/new-antibiotics-and-antimicrobial-combination-therapy-for-the-treatment-of-gram-negative-bacterial-infections
#1
REVIEW
Matteo Bassetti, Elda Righi
PURPOSE OF REVIEW: Increasing rates of life-threatening infections due to multidrug-resistant (MDR) gram-negative bacteria, such as carbapenemase-producer strains, as well as pathogens that are resistant to all current therapeutic options, have been reported. The number of compounds that are currently being developed is still insufficient to control this global threat. We have reviewed the current available options for the treatment of MDR gram-negative infections, including combination regimens employing older antimicrobials and new compounds...
October 2015: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/25667169/development-of-novel-antibacterial-drugs-to-combat-multiple-resistant-organisms
#2
REVIEW
Matteo Bassetti, Elda Righi
BACKGROUND: Infections due to multidrug-resistant (MDR) bacteria are increasing both in hospitals and in the community and are characterized by high mortality rates. New molecules are in development to face the need of active compounds toward resistant gram-positive and gram-negative pathogens. In particular, the Infectious Diseases Society of America (IDSA) has supported the initiative to develop ten new antibacterials within 2020. Principal targets are the so-called ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, and Enterobacteriaceae)...
February 2015: Langenbeck's Archives of Surgery
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