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https://www.readbyqxmd.com/read/27544391/kaleidoscope-of-autoimmune-diseases-in-hiv-infection
#1
Justyna Roszkiewicz, Elzbieta Smolewska
Within the last 30 years, the human immunodeficiency virus (HIV) infection has changed its status from inevitably fatal to chronic disorder with limited impact on life span. However, this breakthrough was mainly the effect of introduction of the aggressive antiviral treatment, which has led to the clinically significant increase in CD4+ cell count, resulting in fewer cases of the acquired immunodeficiency syndrome (AIDS) and improved management of opportunistic infections occurring in the course of the disease...
November 2016: Rheumatology International
https://www.readbyqxmd.com/read/27335659/standardised-incidence-ratios-sirs-for-cancer-after-renal-transplant-in-systemic-lupus-erythematosus-sle-and-non-sle-recipients
#2
Rosalind Ramsey-Goldman, Amarpali Brar, Carrie Richardson, Moro O Salifu, Ann Clarke, Sasha Bernatsky, Dimitre G Stefanov, Rahul M Jindal
OBJECTIVE: We investigated malignancy risk after renal transplantation in patients with and without systemic lupus erythematosus (SLE). METHODS: Using the United States Renal Data System from 2001 to 2009, 143 652 renal transplant recipients with and without SLE contributed 585 420 patient-years of follow-up to determine incident cancers using Medicare claims codes. We calculated standardised incidence ratios (SIRs) of cancer by group using age, sex, race/ethnicity-specific and calendar year-specific cancer rates compared with the US population...
2016: Lupus Science & Medicine
https://www.readbyqxmd.com/read/26228830/superficial-morphea-of-the-lips-and-gingiva
#3
LETTER
Vanja Vučićević Boras, Dora Gabrić, Vlaho Brailo, Nada Čikeš, Danko Velimir Vrdoljak
No abstract text is available yet for this article.
2015: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/24552867/drug-induced-liver-injury-accuracy-of-diagnosis-in-published-reports
#4
REVIEW
Rolf Teschke, Christian Frenzel, Albrecht Wolff, Axel Eickhoff, Johannes Schulze
The diagnosis of drug induced liver injury (DILI) is based primarily on the exclusion of alternative causes. To assess the frequency of alternative causes in initially suspected DILI cases, we searched the Medline database with the following terms: drug hepatotoxicity, drug induced liver injury, and hepatotoxic drugs. For each term, we used the first 100 publications. We reviewed references, selected those reports relevant to our study, and retrieved finally 15 publications related to DILI and alternative causes...
March 2014: Annals of Hepatology
https://www.readbyqxmd.com/read/24135463/effects-of-lersivirine-on-canine-and-rodent-thyroid-function
#5
Christopher D Houle, Gregory L Finch, Robert J Mauthe, David M Potter, Jacqueline A Walisser, Iain B Gardner, Robert H DeWit
Lersivirine is a nonnucleoside reverse transcriptase inhibitor (NNRTI) being developed for the treatment of HIV-1 infection. Like other NNRTIs, lersivirine is a potent enzyme inducer in rodents capable of inducing a number of hepatic enzymes including those involved in its own metabolism. Preclinically lersivirine has been associated with hepatocellular hypertrophy and thyroid gland follicular cell hypertrophy in rats, mice, and dogs. In rodents, we show that development of thyroid hypertrophy is related to the classic mechanism, namely increased thyroxine (T4) clearance secondary to induction of uridine-diphosphoglucuronosyltransferase (UDPGT) in the liver and a resulting increase in thyroid-stimulating hormone...
July 2014: Toxicologic Pathology
https://www.readbyqxmd.com/read/24001424/acquired-unilateral-nevoid-telangiectasia-syndrome-accompanied-by-chronic-hepatitis-b-virus-infection
#6
LETTER
Hakan Turan, Ibak Gönen, Hülya Albayrak, Cihangir Aliağaoğlu
No abstract text is available yet for this article.
2013: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/23699829/puzzling-dyspnea
#7
Melvin Tay, Tow Keang Lim, Pyng Lee
SESSION TYPE: Miscellaneous Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: We present a clinical puzzle of a middle aged man with worsening dyspnea.CASE PRESENTATION: A 65-year-old Chinese man presented to the respiratory unit for progressive dyspnea of 6 months' duration. He first consulted Cardiology 2 months ago for the same complaint. He did not have accompanying chest pain, orthopnea, paroxysmal nocturnal dyspnea or leg edema. He did not complain of cough, wheeze or weight loss...
October 1, 2012: Chest
https://www.readbyqxmd.com/read/22997955/-a-case-of-igg4-related-sclerosing-disease-with-lymphadenopathy-and-thymus-involvement
#8
I A Kazantseva, S V Lishchuk, L E Gurevich, M A Bobrov, S A Terpigorov
The paper describes a case of generalized lymphadenopathy clinically recognized as malignant lymphoma in a 59-year-old woman. Her death occurred from bilateral pneumonia. Autopsy also showed a tumor-like mass in the thymus. On histological examination, the lymph nodes, thymus, and spleen exhibited an intensive polyclonal IgG4+ plasma cell infiltration. Lymphoid plasma cell infiltration with increased count of IgG+ plasma cells, progressive sclerosis, and phlebitis obliterans were found in the pancreas and peripancreatic adipose tissue, liver, kidney, epicardium, thyroid, pituitary, skin, and other organs...
July 2012: Arkhiv Patologii
https://www.readbyqxmd.com/read/22693599/post-arrival-health-screening-in-karen-refugees-in-australia
#9
Georgia A Paxton, Katrina J Sangster, Ellen L Maxwell, Catherine R J McBride, Ross H Drewe
OBJECTIVE: To document the prevalence of nutritional deficiencies, infectious diseases and susceptibility to vaccine preventable diseases in Karen refugees in Australia. DESIGN: Retrospective audit of pathology results. SETTING: Community based cohort in Melbourne over the period July 2006-October 2009. PARTICIPANTS: 1136 Karen refugee children and adults, representing almost complete local area settlement and 48% of total Victorian Karen humanitarian intake for the time period...
2012: PloS One
https://www.readbyqxmd.com/read/22454828/thalassemia-major-in-adults-short-stature-hyperpigmentation-inadequate-chelation-and-transfusion-transmitted-infections-are-key-features
#10
Anupam Prakash, Ramesh Aggarwal
BACKGROUND: Effective transfusion and chelation have prolonged the quality and longevity of life in thalassemics, who now survive into adulthood. Hence, adult physicians need to be aware of their clinical and laboratory profile and the problems faced by them. AIM: The present study was aimed to evaluate the clinical profile of adult thalassemics. MATERIALS AND METHODS: Adult (>18 years) thalassemia major patients (n=19) were evaluated clinically and fasting pretransfusion blood samples were analyzed for complete blood counts, kidney and liver function tests, plasma glucose, serum ferritin, and thyroid hormone levels...
March 2012: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/22276150/expression-of-the-stress-response-oncoprotein-ledgf-p75-in-human-cancer-a-study-of-21-tumor-types
#11
Anamika Basu, Heather Rojas, Hiya Banerjee, Irena B Cabrera, Kayla Y Perez, Marino De León, Carlos A Casiano
Oxidative stress-modulated signaling pathways have been implicated in carcinogenesis and therapy resistance. The lens epithelium derived growth factor p75 (LEDGF/p75) is a transcription co-activator that promotes resistance to stress-induced cell death. This protein has been implicated in inflammatory and autoimmune conditions, HIV-AIDS, and cancer. Although LEDGF/p75 is emerging as a stress survival oncoprotein, there is scarce information on its expression in human tumors. The present study was performed to evaluate its expression in a comprehensive panel of human cancers...
2012: PloS One
https://www.readbyqxmd.com/read/21551028/characterization-of-xenobiotic-induced-hepatocellular-enzyme-induction-in-rats-anticipated-thyroid-effects-and-unique-pituitary-gland-findings
#12
Tanja S Zabka, Mark R Fielden, Rosario Garrido, Jianhua Tao, Adrian J Fretland, Jennifer L Fretland, Mudher A Albassam, Thomas Singer, Kyle L Kolaja
During routine safety evaluation of RO2910, a non-nucleoside reverse transcriptase inhibitor for HIV infection, histopathology findings concurrent with robust hepatocellular induction occurred in multiple organs, including a unique, albeit related, finding in the pituitary gland. For fourteen days, male and female rats were administered, by oral gavage vehicle, 100, 300, or 1000 mg/kg/day of RO2910. Treated groups had elevated serum thyroid-stimulating hormone and decreased total thyroxine, and hypertrophy in the liver, thyroid gland, and pituitary pars distalis...
June 2011: Toxicologic Pathology
https://www.readbyqxmd.com/read/20371429/extrahepatic-manifestations-associated-with-chronic-hepatitis-c-infections-in-poland
#13
D A Zarebska-Michaluk, D M Lebensztejn, W M Kryczka, E Skiba
PURPOSE: To assess the prevalence and predictive factors of extrahepatic manifestation (EM) in patients with chronic hepatitis C (CHC) infection in Poland. MATERIAL AND METHODS: 340 consecutive patients (mean age: 42 years) with untreated CHC were studied between 2000 and 2006. The HCV infection was defined by positive serology and serum HCV RNA. The inflammation grade and fibrosis stage were assessed according to Ishak. Demographic, laboratory and liver biopsy data were collected...
2010: Advances in Medical Sciences
https://www.readbyqxmd.com/read/20066157/the-challenge-of-aids-related-malignancies-in-sub-saharan-africa
#14
Annie J Sasco, Antoine Jaquet, Emilie Boidin, Didier K Ekouevi, Fabian Thouillot, Thomas Lemabec, Marie-Anna Forstin, Philippe Renaudier, Paul N'dom, Denis Malvy, François Dabis
BACKGROUND: With the lengthening of life expectancy among HIV-positive subjects related to the use of highly active antiretroviral treatments, an increased risk of cancer has been described in industrialized countries. The question is to determine what occurs now and will happen in the future in the low income countries and particularly in sub-Saharan Africa where more than two-thirds of all HIV-positive people live in the world. The objective of our paper is to review the link between HIV and cancer in sub-Saharan Africa, putting it in perspective with what is already known in Western countries...
January 11, 2010: PloS One
https://www.readbyqxmd.com/read/18096469/other-immune-thrombocytopenias
#15
REVIEW
Howard Liebman
Immune thrombocytopenic purpura (ITP) can be classified as primary (known also as idiopathic thrombocytopenic purpura) or as secondary to an underlying condition such as a malignant or nonmalignant disorder. Commonly occurring conditions associated with secondary ITP include lymphoproliferative disorders (chronic lymphocytic leukemia [CLL], Hodgkin's disease and non-Hodgkin's lymphomas), autoimmune collagen vascular diseases (systemic lupus erythematosus [SLE], thyroid disease, antiphospholipid syndrome [APS]), and chronic infections (human immunodeficiency virus [HIV], Helicobacter pylori, hepatitis C virus [HCV])...
October 2007: Seminars in Hematology
https://www.readbyqxmd.com/read/17629802/prognosis-screening-early-detection-and-differentiation-of-arterial-pulmonary-hypertension
#16
REVIEW
Guido Domenighetti
Pulmonary hypertension (PH) has been partially reclassified during the 2003 Third World Symposium on Pulmonary Arterial Hypertension held in Venice. PH is a common disorder that may complicate a variety of cardiopulmonary diseases, including severe COPD, left ventricular failure and chronic thromboembolic obstruction of the pulmonary arteries. Pulmonary arterial hypertension (PAH) is an increase in pulmonary arterial pressure which is not due to classical coexistent cardiopulmonary disease. PAH usually occurs in the absence of an evident cause (idiopathic or familial) or it may be associated with connective tissue disease, HIV infection, chronic liver disease, congenital systemic-to-pulmonary shunts, venous or capillary involvement, thyroid or myeloproliferative disorders as well as a result of the use of toxic agents and anorexigens...
June 16, 2007: Swiss Medical Weekly
https://www.readbyqxmd.com/read/17443443/-generalized-lymphadenitis-associated-with-hashimoto-s-thyroiditis
#17
A Brecht, Th Stiegler, J Lange, K de Groot
HISTORY AND ADMISSION FINDINGS: A 26-year-old Pakistani woman was admitted to hospital with fever, nausea and vomiting, abdominal pain and general weakness for the previous two weeks, but no diarrhea or constipation. Antibiotic therapy as an out-patient had not provided relief. She also had enlarged cervical lymph nodes. She reported that she had always been in good health before onset of the described symptoms. INVESTIGATIONS: Laboratory tests revealed pancytopenia and a decrease in C3 and C4...
April 20, 2007: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/16528368/anatomical-mapping-of-human-herpesvirus-reservoirs-of-infection
#18
Tiansheng Chen, S David Hudnall
Following primary infection, all eight human herpesviruses persist lifelong in the human host. However, a mapping of all anatomic sites of human herpesvirus persistence is lacking. Fresh tissue specimens representing approximately 40 major anatomic sites from eight autopsies were screened using a recently developed real-time PCR method for detection of all eight human herpesviruses. Patients with evidence of active herpesvirus infection (herpes simplex 1 (HSV-1), herpes simplex 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpesvirus 6 (HHV-6), herpesvirus 7 (HHV-7), and herpesvirus 8 (HHV-8)) at the time of death were excluded to avoid detection of widely disseminated infection...
May 2006: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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