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https://www.readbyqxmd.com/read/29779206/old-new-and-emerging-immunohistochemical-markers-in-pheochromocytoma-and-paraganglioma
#1
REVIEW
Veronica K Y Cheung, Anthony J Gill, Angela Chou
The evolution of genetic research over the past two decades has greatly improved the understanding of pheochromocytomas and paragangliomas. It is now accepted that more than one third of pheochromocytoma and paragangliomas arise in the context of syndromic disease, usually hereditary. The genetic profile of these tumors also has important prognostic implications which may help guide treatment. Accompanying the changing molecular landscape is the development of new immunohistochemical markers. Initially used in assisting with diagnosis, immunohistochemical markers have now become an important adjunct to screening programs for inherited conditions and subsequently as prognostic markers...
May 19, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29779161/empowering-lay-counsellors-with-technology-masivukeni-a-standardized-multimedia-counselling-support-tool-to-deliver-art-counselling
#2
H Gouse, R N Robbins, C A Mellins, A Kingon, J Rowe, M Henry, R H Remien, A Pearson, F Victor, J A Joska
Lay-counsellors in resource-limited settings convey critical HIV- and ART-information, and face challenges including limited training and variable application of counselling. This study explored lay-counsellors and Department of Health (DoH) perspectives on the utility of a multimedia adherence counselling program. Masivukeni, an mHealth application that provides scaffolding for delivering standardized ART counselling was used in a 3-year randomized control trail at two primary health care clinics in Cape Town, South Africa...
May 19, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29779135/novel-evaluation-scale-for-qol-qol-acd-bp-in-preoperative-chemotherapy-for-breast-cancer
#3
Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Katsuyuki Takahashi, Tamami Morisaki, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa, Masaichi Ohira
PURPOSE: Quality-of-life (QOL) has been reported to affect the prognosis of many types of cancer, and several studies used various QOL assessment tools to determine the relationship between QOL and cancer prognosis. In this study, QOL-Questionnaire for Cancer Patients Treated with Anti-Cancer Drugs-the Breast (QOL-ACD-B) was modified to be suitable for preoperative chemotherapy (POC) and was named the QOL-ACD-BP. METHODS: A total of 300 patients were treated with POC after being diagnosed with breast cancer between February 2007 and December 2016 at our institute...
May 19, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29779074/health-information-seeking-behavior-among-college-students
#4
Corey H Basch, Sarah A MacLean, Rachelle-Ann Romero, Danna Ethan
Individuals have a wide range of resources when searching for health topics. The aim of this research was twofold: (1) to identify and assess the resources college students use when exercising health information seeking behavior (HISB); and (2) to examine perceptions and behaviors regarding adoption of online tools. A questionnaire was developed to assess HISB in a sample of college students. Items pertaining to HISB were adapted from a Health Information National Trends Survey with permission from the National Cancer Institute at the National Institutes of Health...
May 19, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29778930/measurement-properties-of-tools-used-to-assess-suicidality-in-autistic-and-general-population-adults-a-systematic-review
#5
REVIEW
S A Cassidy, L Bradley, E Bowen, S Wigham, J Rodgers
Adults diagnosed with autism are at significantly increased risk of suicidal thoughts, suicidal behaviours and dying by suicide. However, it is unclear whether any validated tools are currently available to effectively assess suicidality in autistic adults in research and clinical practice. This is crucial for understanding and preventing premature death by suicide in this vulnerable group. This two stage systematic review therefore aimed to identify tools used to assess suicidality in autistic and general population adults, evaluate these tools for their appropriateness and measurement properties, and make recommendations for appropriate selection of suicidality assessment tools in research and clinical practice...
May 5, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29778898/examining-the-diagnostic-accuracy-of-static-postural-stability-measures-in-differentiating-among-knee-osteoarthritis-patients-with-mild-and-moderate-to-severe-radiographic-signs
#6
Nahid Pirayeh, Mohammad-Jafar Shaterzadeh-Yazdi, Hossein Negahban, Mohammad Mehravar, Neda Mostafaee, Amal Saki-Malehi
BACKGROUND: Clinicians need a reliable and accurate tools that can best identify and classify balance impairments between mild and moderate to severe grades of knee osteoarthritis (OA). RESEARCH QUESTION: This study was designed to investigate the accuracy of postural measurements to discriminate between these two groups of knee OA. METHODS: A total of 130 patients with knee OA based on the Kellgren-Lawrence (KL) grading scale were categorized into 65 patients with mild (a KL grade≤ 2) and 65 patient with moderate to severe (a KL grade≥3) radiographic sign...
May 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29778849/influence-of-aortic-dilation-on-the-regional-aortic-stiffness-of-bicuspid-aortic-valve-assessed-by-4-dimensional-flow-cardiac-magnetic-resonance-comparison-with-marfan-syndrome-and-degenerative-aortic-aneurysm
#7
Andrea Guala, Jose Rodriguez-Palomares, Lydia Dux-Santoy, Gisela Teixido-Tura, Giuliana Maldonado, Laura Galian, Marina Huguet, Filipa Valente, Laura Gutiérrez, Teresa González-Alujas, Kevin M Johnson, Oliver Wieben, Augusto Sao Avilés, David Garcia-Dorado, Arturo Evangelista
OBJECTIVES: This study sought to ascertain whether patients with a bicuspid aortic valve (BAV) have an intrinsic alteration in regional aortic stiffness compared with patients with tricuspid aortic valve (TAV) and Marfan syndrome (MFS) patients with similar aortic sizes, as well as to assess the influence of ascending aorta (AAo) dilation on regional stiffness parameters in BAV patients. BACKGROUND: Imaging biomarkers as predictors of BAV, MFS, and degenerative AAo aneurysms in TAV patients (DA-TAV) are lacking...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778756/nurses-knowledge-attitudes-and-clinical-practice-in-pediatric-postoperative-pain-management
#8
Anja Hetland Smeland, Alison Twycross, Stefan Lundeberg, Tone Rustøen
Despite readily available evidence to guide practice, children continue to experience moderate to severe pain in hospital postoperatively. Reasons for this may include attitudes of nurses toward pain management and their lack of knowledge in key areas. To identify nurses' knowledge and clinical practice of pediatric postoperative pain management and whether there is a link between knowledge and practice. A descriptive cross-sectional study including a questionnaire and observations was conducted in postanesthesia care (recovery) units in six university hospitals in Norway...
May 16, 2018: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29778752/tools-to-assess-living-with-a-chronic-illness-a-systematic-review
#9
Leire Ambrosio, Mari Carmen Portillo
OBJECTIVE: To analyse the currently available instruments to assess living with a chronic illness and related aspects. METHOD: A review of the evidence was made using the databases: Medline, CINHAL, PsycINFO, Cochrane Library, Embase and Cuiden. The criteria that limited the search were: the language, English and / or Spanish and studies carried out in an adult population. Years of article publication were not used as a limit. RESULTS: A total of 16 instruments were identified and analysed that apparently measured the concept of living with a chronic illness and/or related aspects...
May 16, 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29778712/validation-reliability-and-specificity-of-clinicom%C3%A2-psychiatric-assessment-software
#10
Nelson Handal, James LePage, Philip Dayley, Barbara Baldwin, Amellia Roeser, Joni Kay, Heather Ann Theobald, Michael Nellamattathil, Scott Drotar, Connor Weir, Neil Tindell, Kevin Tice
The purpose of this study was to determine the specificity and reproducibility of CliniCom™ Psychiatric Assessment Software to appropriately diagnose five prevalent mental health disorders. This online assessment tool incorporates proprietary algorithms for its propensity assessment. Unlike other questionnaires, which require a survey per specific mental disorder, CliniCom can simultaneously assess multiple mental disorders for an individual. CliniCom was concordant with other commonly used assessment tools in diagnosing five prevalent disorders including: Attention Deficit and Hyperactivity Disorder, Generalized Anxiety Disorder, Major Depressive Disorder, Obsessive Compulsive Disorder, and Social Phobia...
May 12, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29778403/the-cf-sputum-induction-trial-cf-spit-to-assess-lower-airway-bacterial-sampling-in-young-children-with-cystic-fibrosis-a-prospective-internally-controlled-interventional-trial
#11
Katherine Ronchetti, Jo-Dee Tame, Christopher Paisey, Lena P Thia, Iolo Doull, Robin Howe, Eshwar Mahenthiralingam, Julian T Forton
BACKGROUND: Pathogen surveillance is challenging but crucial in children with cystic fibrosis-who are often non-productive of sputum even if actively coughing-because infection and lung disease begin early in life. The role of sputum induction as a diagnostic tool for infection has not previously been systematically addressed in young children with cystic fibrosis. We aimed to assess the pathogen yield from sputum induction compared with that from cough swab and single-lobe, two-lobe, and six-lobe bronchoalveolar lavage...
May 16, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29778343/community-pharmacy-minor-ailment-services-in-england-pharmacy-stakeholder-perspectives-on-the-factors-affecting-sustainability
#12
Hamde Nazar, Zachariah Nazar
BACKGROUND: Self-care advice and management of minor ailments have long been provided in community pharmacies across England. However, formal pharmacy minor ailment service provision is geographically variable and has yet to gain recognition and political support as a valued sustainable service for nationwide adoption and commissioning. OBJECTIVE: To investigate the sustainability potential of pharmacy minor ailment services from the perspective of community pharmacy stakeholders within the North East of England...
May 14, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29778093/bio-detheobromination-of-cocoa-pod-husks-reduction-of-ochratoxin-a-content-without-change-in-nutrient-profile
#13
Daniel Oduro-Mensah, Augustine Ocloo, Sammy T Lowor, Cheetham Mingle, Laud K N-A Okine, Naa Ayikailey Adamafio
BACKGROUND: Utilization of cocoa pod husks (CPH) in animal feed is hindered by the presence of theobromine, which is variably toxic to animals. Treatment of this agro-waste to remove theobromine, while preserving its nutrient content, would allow beneficial use of the millions of metric tonnes discarded annually. The aim of this study was to assess the suitability of selected theobromine-degrading filamentous fungi for use as bio-tools in degradation of theobromine in CPH. RESULTS: The candidate fungi assessed in this study were an Aspergillus niger (AnTD) and three Talaromyces spp...
May 19, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29778092/magnetic-resonance-imaging-for-detecting-root-avulsions-in-traumatic-adult-brachial-plexus-injuries-protocol-for-a-systematic-review-of-diagnostic-accuracy
#14
Ryckie G Wade, Yemisi Takwoingi, Justin C R Wormald, John P Ridgway, Steven Tanner, James J Rankine, Grainne Bourke
BACKGROUND: Adult brachial plexus injuries (BPI) are becoming more common. The reconstruction and prognosis of pre-ganglionic injuries (root avulsions) are different to other types of BPI injury. Preoperative magnetic resonance imaging (MRI) is being used to identify root avulsions, but the evidence from studies of its diagnostic accuracy are conflicting. Therefore, a systematic review is needed to address uncertainty about the accuracy of MRI and to guide future research. METHODS: We will conduct a systematic search of electronic databases alongside reference tracking...
May 19, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29778054/at-risk-symptoms-of-bipolar-disorder-in-a-university-student-cohort
#15
Ida S Haussleiter, Sandra Lorek, Eike Zeschel, Svenja Mattausch, Milena Meyers, Georg Juckel
To assess the occurrence and frequency of bipolar at-risk symptoms in a large sample of previously undiagnosed students using the new screening tool Bochumer Screeningbogen Bipolar (BSB). 2329 students of the Ruhr-University Bochum, Germany completed online demographic data as well as various self-rating questionnaires (BSB; Hypomania Checklist 32; Altman Self-Rating Mania Scale; Beck Depression Inventory). Within the student cohort (64.4% female, mean age 24.3 years) every fifth student currently suffered from moderate to severe depressive symptoms; every sixth student had already thought about suicide and every other student reported a history of mood swings...
May 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29778042/reliability-and-validity-of-the-dymus-questionnaire-for-the-assessment-of-dysphagia-in-multiple-sclerosis-greek-version-and-proposed-modification
#16
Athanasia Printza, Maria Kalaitzi, Christos Bakirtzis, Ioannis Nikolaidis, Hariklia Proios, Nikolaos Grigoriadis
BACKGROUND: Recent research confirmed that at least a third of people with multiple sclerosis (MS) are suffering from swallowing difficulties. Dysphagia is associated with significant morbidity and mortality, and has profound impact on physical ability and quality of life. Dysphagia related complications can be prevented through an effective screening protocol. The Dysphagia in Multiple Sclerosis (DYMUS) questionnaire is the first dysphagia questionnaire developed specifically for patients with MS...
May 10, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29777998/an-integrated-modeling-approach-for-estimating-hydrologic-responses-to-future-urbanization-and-climate-changes-in-a-mixed-use-midwestern-watershed
#17
Michael G Sunde, Hong S He, Jason A Hubbart, Michael A Urban
Future urban development and climatic changes are likely to affect hydrologic regimes in many watersheds. Quantifying potential water regime changes caused by these stressors is therefore crucial for enabling decision makers to develop viable environmental management strategies. This study presents an approach that integrates mid-21st century impervious surface growth estimates derived from the Imperviousness Change Analysis Tool with downscaled climate model projections and a hydrologic model Soil and Water Assessment Tool to characterize potential water regime changes in a mixed-use watershed in central Missouri, USA...
May 16, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29777798/predominance-of-high-or-unclear-risk-of-bias-assessments-in-diagnostic-accuracy-studies-included-in-cochrane-reviews
#18
Nicola Di Girolamo, Alexandra Winter, Reint Meursinge Reynders
OBJECTIVES: The validity of outcomes of systematic reviews is highly dependent on the extent of bias in the included primary studies. This study reports the risk of bias of primary studies included in systematic reviews of diagnostic accuracy. STUDY DESIGN AND SETTING: All systematic reviews of diagnostic accuracy studies published in the Cochrane database in 2015 and 2016 that used the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) risk of bias (ROB) tool, and reported results with the ROB figure were eligible...
May 16, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29777773/progress-in-formulation-development-and-sterilisation-of-freeze-dried-oligodeoxynucleotide-loaded-gelatine-nanoparticles
#19
Katharina J Geh, Madlen Hubert, Gerhard Winter
Oligodeoxynucleotide (ODN)-loaded gelatine nanoparticles (GNPs) have proven their outstanding potential in the treatment of allergic diseases such as equine asthma and canine atopic dermatitis, which are appropriate models for the corresponding human diseases. To encourage the development of a marketable product, long term stability and sterility needs to be ensured. In this work, we aimed to advance freeze-drying options to stabilise ODN-loaded GNPs. Matrix-assisted laser desorption/ionisation mass spectrometry time-of-flight was implemented as a versatile tool to assess ODN stability...
May 16, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29777770/construction-and-feasibility-study-of-the-sofmer-activity-score-sas-a-new-assessment-of-physical-and-cognitive-activity
#20
M D Morard, S Gonzalez-Monge, P Rippert, S Roche, J C Bernard, D Lagauche, C Delvert, J Luauté, S Jacquin Courtois, F Caillet, J Di Marco, F Ghelfi, S Otmani, P Calmels, M Royet, P A Joseph, R Ecochard, G Rode, C Vuillerot
OBJECTIVES: For hospitalizations in rehabilitation centers (RCs) in France, the quantification of healthcare givers' activity is based on the dependency of the patients, defined as a total or partial inability to perform activities required for daily living without help. The tools currently used to quantify dependency are not sufficiently precise. Here we describe the construction of a new tool, the SOFMER Activity Score (SAS scoring), which allows for a good description of the level of activity of patients hospitalized in RCs, and a feasibility study of the tool...
May 16, 2018: Annals of Physical and Rehabilitation Medicine
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