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https://www.readbyqxmd.com/read/28726594/crowding-karenina-and-complexity-patient-flow-in-evolving-health-care-ecosystems
#1
David A Petrie
No abstract text is available yet for this article.
July 20, 2017: CJEM
https://www.readbyqxmd.com/read/28725402/what-does-body-size-mean-from-the-plant-s-eye-view
#2
Amanda J Tracey, Kimberly A Stephens, Brandon S Schamp, Lonnie W Aarssen
Alternative metrics exist for representing variation in plant body size, but the vast majority of previous research for herbaceous plants has focused on dry mass. Dry mass provides a reasonably accurate and easily measured estimate for comparing relative capacity to convert solar energy into stored carbon. However, from a "plant's eye view", its experience of its local biotic environment of immediate neighbors (especially when crowded) may be more accurately represented by measures of "space occupancy" (S-O) recorded in situ-rather than dry mass measured after storage in a drying oven...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28720791/in-vivo-analysis-of-protein-crowding-within-the-nuclear-pore-complex-in-interphase-and-mitosis
#3
Hide A Konishi, Suguru Asai, Tomonobu M Watanabe, Shige H Yoshimura
The central channel of the nuclear pore complex (NPC) is occupied by non-structured polypeptides with a high content of Phe-Gly (FG) motifs. This protein-rich environment functions as an entropic barrier that prevents the passage of molecules, as well as the binding sites for karyopherins, to regulate macromolecular traffic between the nucleoplasm and the cytoplasm. In this study, we expressed individual Nups fused with a crowding-sensitive probe (GimRET) to determine the spatial distribution of protein-rich domains within the central channel in vivo, and characterize the properties of the entropic barrier...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720653/three-dimensional-structural-analysis-reveals-a-cdk5-mediated-kinase-cascade-regulating-hepatic-biliary-network-branching-in-zebrafish
#4
Manali Dimri, Cassandra Bilogan, Lain X Pierce, Gregory Naegele, Amit Vasanji, Isabel Gibson, Allyson McClendon, Kevin Tae, Takuya F Sakaguchi
The intrahepatic biliary network is a highly branched three-dimensional network lined by biliary epithelial cells, but how its branching patterns are precisely established is not clear. We designed a new computer-based algorithm that quantitatively computes the structural differences of the three-dimensional networks. Utilizing the algorithm, we showed that inhibition of Cyclin-dependent kinase 5 (Cdk5) led to reduced branching in the intrahepatic biliary network in zebrafish. Further, we identified a previously unappreciated downstream kinase cascade regulated by Cdk5...
July 15, 2017: Development
https://www.readbyqxmd.com/read/28718831/management-effectiveness-of-a-secondary-coniferous-forest-for-landscape-appreciation-and-psychological-restoration
#5
Norimasa Takayama, Akio Fujiwara, Haruo Saito, Masahiro Horiuchi
We investigated the influence of forest management on landscape appreciation and psychological restoration in on-site settings by exposing respondents to an unmanaged, dense coniferous (crowding) forest and a managed (thinned) coniferous forest; we set the two experimental settings in the forests of the Fuji Iyashinomoroi Woodland Study Center. The respondents were individually exposed to both settings while sitting for 15 min and were required to answer three questionnaires to analyze the psychological restorative effects before and after the experiment (feeling (the Profile of Mood States), affect (the Positive and Negative Affect Schedule), and subjective restorativeness (the Restorative Outcome Scale)...
July 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28718468/dna-melting-in-the-presence-of-molecular-crowders
#6
Amar Singh, Navin Singh
We study the opening of double stranded DNA (dsDNA) in the presence of molecular crowders using the Peyrard-Bishop-Dauxois (PBD) model. It is a known fact that about 15-20% of the total volume of a cell is occupied by molecular crowders. The presence of crowders in the model is represented through the potential depth in the Morse potential. Using equilibrium statistical calculations we find the melting profile and the melting probabilities of the chain. We found that the melting temperature, Tm, increases in the presence of a crowder...
July 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28717634/molar-distalization-with-2k-appliance-one-year-follow-up
#7
Tulika Tripathi, Priyank Rai, Navneet Singh
Correction of class II molars in growing patients with acceptable facial profile can be performed by distalization of maxillary first molars. However, in patients where compliance is difficult intraoral means of molar distalization is required. This case report describes the use and effectiveness of a novel 2K appliance in an 11-year-old female having an orthognathic profile, skeletal Class I relation, and Angle's Class II division 1 malocclusion with crowding of 8 mm and 3 mm in the maxillary and mandibular arches, respectively...
July 2017: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/28716908/sequential-eviction-of-crowded-nucleoprotein-complexes-by-the-exonuclease-recbcd-molecular-motor
#8
Tsuyoshi Terakawa, Sy Redding, Timothy D Silverstein, Eric C Greene
In physiological settings, all nucleic acids motor proteins must travel along substrates that are crowded with other proteins. However, the physical basis for how motor proteins behave in these highly crowded environments remains unknown. Here, we use real-time single-molecule imaging to determine how the ATP-dependent translocase RecBCD travels along DNA occupied by tandem arrays of high-affinity DNA binding proteins. We show that RecBCD forces each protein into its nearest adjacent neighbor, causing rapid disruption of the protein-nucleic acid interaction...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28715293/surveillance-for-antibodies-against-six-canine-viruses-in-wild-raccoons-procyon-lotor-in-japan
#9
Emiko Aoki, Takehisa Soma, Mayumi Yokoyama, Makoto Matsubayashi, Kazumi Sasai
Raccoons (Procyon lotor) are found worldwide. They are frequently seen in crowded inner cities as well as in forests or wooded areas, often living in proximity to humans and their pets. We examined sera from 100 wild raccoons in Japan for antibodies to six canine viruses with veterinary significance to assess their potential as reservoirs. We also aimed to understand the distribution of potentially infected wildlife. We found that 7% of samples were seropositive for canine distemper virus (CDV), 10% for canine parvovirus type (CPV), 2% for canine adenovirus type 1, 6% for canine adenovirus type 2, and 7% for canine coronavirus...
July 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28714834/adjusting-patients-streaming-initiated-by-a-wait-time-threshold-in-emergency-department-for-minimizing-opportunity-cost
#10
Byungjoon B J Kim, Theodore R Delbridge, Dawn B Kendrick
Purpose Two different systems for streaming patients were considered to improve efficiency measures such as waiting times (WTs) and length of stay (LOS) for a current emergency department (ED). A typical fast track area (FTA) and a fast track with a wait time threshold (FTW) were designed and compared effectiveness measures from the perspective of total opportunity cost of all patients' WTs in the ED. The paper aims to discuss these issues. Design/methodology/approach This retrospective case study used computerized ED patient arrival to discharge time logs (between July 1, 2009 and June 30, 2010) to build computer simulation models for the FTA and fast track with wait time threshold systems...
July 10, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28713747/the-surgical-management-of-skeletal-disproportion-with-lingual-orthodontics-and-three-dimensional-planning
#11
Krutiben Patel, Chung How Kau, Peter D Waite, Ahmet Arif Celebi
This case report describes the successful treatment of a 26-year-old Caucasian male with skeletal and dental Class III malocclusion associated with mild maxillary and mandibular crowding. The patient had anteroposterior and transverse discrepancies with a reverse overjet and bilateral posterior crossbites. The nonextraction treatment plan included aligning and leveling of the teeth in both arches, Le Fort I and bilateral sagittal split osteotomies, and postsurgical correction of the malocclusion. Orthodontic treatment was initiated with custom lingual appliances followed by orthognathic surgery planned with virtual surgical planning...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28710716/humor-norms-for-4-997-english-words
#12
Tomas Engelthaler, Thomas T Hills
Humor ratings are provided for 4,997 English words collected from 821 participants using an online crowd-sourcing platform. Each participant rated 211 words on a scale from 1 (humorless) to 5 (humorous). To provide for comparisons across norms, words were chosen from a set common to a number of previously collected norms (e.g., arousal, valence, dominance, concreteness, age of acquisition, and reaction time). The complete dataset provides researchers with a list of humor ratings and includes information on gender, age, and educational differences...
July 14, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28709117/increased-risk-of-bipolar-disorder-in-patients-with-scabies-a-nationwide-population-based-matched-cohort-study
#13
Chien-Yu Lin, Fung-Wei Chang, Jing-Jung Yang, Chun-Hung Chang, Chia-Lun Yeh, Wei-Te Lei, Chun-Fa Huang, Jui-Ming Liu, Ren-Jun Hsu
Both scabies and bipolar disorder (BD) are common and troublesome disorders. There are several similarities in both diseases: pruritus, a higher prevalence in crowded environments, and cytokine-mediated inflammatory processes in the pathophysiology. We conducted this nationwide population-based study to investigate the possible relationship between scabies and BD. Based on the National Health Insurance Research Database (NHIRD) of Taiwan, a total of 7096 patients with scabies were identified as a study group and 28,375 matched patients as a control...
July 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28707901/toward-chemically-resolved-computer-simulations-of-dynamics-and-remodeling-of-biological-membranes
#14
Thereza A Soares, Stefano Vanni, Giuseppe Milano, Michele Cascella
Cellular membranes are fundamental constituents of living organisms. Apart from defining the boundaries of the cells, they are involved in a wide range of biological functions, associated to both their structural and the dynamical properties. Bio-membranes can undergo large-scale transformations when subject to specific environmental changes, including gel-liquid phase transitions, change of aggregation structure, formation of microtubules, or rupture into vesicles. All these processes are dependent on a delicate interplay between intermolecular forces, molecular crowding, and entropy, and their understanding requires approaches that are able to capture and rationalize the details of all the involved interactions...
July 14, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28705748/effect-of-secondary-metabolite-of-actinidia-deliciosa-on-the-biofilm-and-extra-cellular-matrix-components-of-acinetobacter-baumannii
#15
Vishvanath Tiwari, Deepika Tiwari, Varsha Patel, Monalisa Tiwari
Acinetobacter baumannii, opportunistic nosocomial pathogen, increases gradually in the clinical setup. The high level of resistance mechanisms acquired by these bacteria makes their eradication difficult and biofilm formation is one of them. Biofilm comprises of closely packed bacterial population crowded together by extra-cellular matrix (ECM). ECM contains bacterial secreted polymers such as exopolysaccharides (EPS), proteins and extracellular-DNA (e-DNA) and rarely amyloidogenic proteins. Biofilm offers protection of underlying bacterial population against chemotherapeutic agents and host immune system...
July 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28705743/the-influence-of-crowding-on-clinical-practice-in-the-emergency-department
#16
I-Min Chiu, Yan-Ren Lin, Yuan-Jhen Syue, Chia-Te Kung, Kuan-Han Wu, Chao-Jui Li
BACKGROUND: This study aimed to clarify the association between the crowding and clinical practice in the emergency department (ED). METHODS: This 1-year retrospective cohort study conducted in two EDs in Taiwan included 70,222 adult non-trauma visits during the day shift between July 1, 2011, and June 30, 2012. The ED occupancy status, determined by the number of patients staying during their time of visit, was used to measure crowding, grouped into four quartiles, and analyzed in reference to the clinical practice...
July 4, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28705040/minimal-limited-pseudohyperplastic-prostatic-adenocarcinoma-in-needle-prostatic-biopsy
#17
Julian Arista-Nasr, Braulio Martinez-Benitez, Alejandra Mijangos-Trejo, Leticia Bornstein-Quevedo, Jorge Albores-Saavedra
BACKGROUND: Study of minimum adenocarcinoma has been done almost exclusively on conventional acinar adenocarcinoma. Pseudohyperplastic adenocarcinoma can be confused with benign lesions because of its well-differentiated appearance and has not been studied when the biopsy shows few malignant glands (limited carcinoma). METHODS: We reviewed 94 pseudohyperplastic adenocarcinomas diagnosed in prostatic biopsies for a period of 12 years and selected those measuring less than 1 mm or involving less than 5% of the biopsied tissue...
July 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28704969/urban-green-space-perception-and-its-contribution-to-well-being
#18
Gyula Kothencz, Ronald Kolcsár, Pablo Cabrera-Barona, Péter Szilassi
Individual perceptions are essential when evaluating the well-being benefits from urban green spaces. This study predicted the influence of perceived green space characteristics in the city of Szeged, Hungary, on two well-being variables: the green space visitors' level of satisfaction and the self-reported quality of life. The applied logistic regression analysis used nine predictors: seven perceived green space characteristics from a questionnaire survey among visitors of five urban green spaces of Szeged; and the frequency of green space visitors' crowd-sourced recreational running paths and photographs picturing green space aesthetics...
July 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28702922/public-expenditure-and-healthcare-utilization-the-case-of-reproductive-health-care-in-india
#19
Dhiman Das
An important reason for public intervention in health in developing countries is to address the issue of accessibility. However, numerous studies have found inconclusive evidence of the effect of public expenditure on health outcomes. Here, I revisit the debate by examining the effect of public expenditure on the use of health services, which is an important link between expenditure and outcomes. I use data from two recent waves of the National Family Health Survey of India to study the role of public expenditure on the use of healthcare services during pregnancy and childbirth...
July 12, 2017: International Journal of Health Economics and Management
https://www.readbyqxmd.com/read/28702592/inhibition-of-gnnqqny-prion-peptide-aggregation-by-trehalose-a-mechanistic-view
#20
Nidhi Katyal, Shashank Deep
Deposition of amyloid fibrils is the seminal event in the pathogenesis of numerous neurodegenerative diseases. The formation of this amyloid assembly is the manifestation of a cascade of structural transitions including toxic oligomer formation in the early stages of aggregation. Thus a viable therapeutic strategy involves the use of small molecular ligands to interfere with this assembly. In this perspective, we have explored the kinetics of aggregate formation of the fibril forming GNNQQNY peptide fragment from the yeast prion protein SUP35 using multiple all atom MD simulations with explicit solvent and provided mechanistic insights into the way trehalose, an experimentally known aggregation inhibitor, modulates the aggregation pathway...
July 12, 2017: Physical Chemistry Chemical Physics: PCCP
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