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https://www.readbyqxmd.com/read/29332818/a-novel-dual-labeling-approach-enables-converting-fluorescence-labeling-reagents-into-fluorogenic-ones-via-introduction-of-purification-tags-application-to-determination-of-glyoxylic-acid-in-serum
#1
Mahmoud El-Maghrabey, Masaki Mine, Naoya Kishikawa, Kaname Ohyama, Naotaka Kuroda
Pre-column derivatization with fluorescence labeling reagents involves many problems including crowded chromatograms, possibility of the introduction of analytical errors, and poor selectivity. Herein we report a novel purification tag/fluorophore dual labeling approach based on a multi-component reaction to solve this major problem. Glyoxylic acid was recently identified as an early biomarker for diabetes, thus it was selected as a model analyte for our new dual labeling approach. Using the multi-component Petasis reaction, we could introduce a fluorophore (1-pyreneboronic acid, 1-PyBA) and a purification tag (taurine) to our target analyte (glyoxylic acid) in one step reaction...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29331348/effects-of-l-tryptophan-on-the-growth-intestinal-enzyme-activities-and-non-specific-immune-response-of-sea-cucumber-apostichopus-japonicus-selenka-exposed-to-crowding-stress
#2
Endong Zhang, Shuanglin Dong, Fang Wang, Xiangli Tian, Qinfeng Gao
In order to reveal the effects of l-tryptophan (Trp) on the physiology and immune response of sea cucumber (Apostichopus japonicus Selenka) exposed to crowding stress, four density groups of sea cucumbers (i.e. 4, 8, 16 and 32 individuals per 40 L water, represented as L, ML, MH and H) were fed with diets containing 0, 1, 3 and 5% l-tryptophan respectively for 75 days. The results showed that the specific growth rates (SGR) of the sea cucumber fed with diet with 3% Trp (L, 2.1; ML, 1.76; MH, 1.2; H, 0.7) were significantly higher than those fed with basal diet without Trp supplementation (P < ...
January 10, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29330855/getting-innovative-therapies-faster-to-patients-at-the-right-dose-impact-of-quantitative-pharmacology-towards-first-registration-and-expanding-therapeutic-use
#3
Satyaprakash Nayak, Oliver Sander, Nidal Al-Huniti, Dinesh de Alwis, Anne Chain, Marylore Chenel, Soujanya Sunkaraneni, Shruti Agrawal, Neeraj Gupta, Sandra A G Visser
Quantitative pharmacology (QP) applications in translational medicine, drug-development, and therapeutic use were crowd-sourced by the ASCPT Impact and Influence initiative. Highlighted QP case studies demonstrated faster access to innovative therapies for patients through 1) rational dose selection for pivotal trials; 2) reduced trial-burden for vulnerable populations; or 3) simplified posology. Critical success factors were proactive stakeholder engagement, alignment on the value of model-informed approaches, and utilizing foundational clinical pharmacology understanding of the therapy...
January 13, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29330584/a-dedicated-neurologist-at-the-emergency-department-during-out-of-office-hours-decreases-patients-length-of-stay-and-admission-percentages
#4
M Christien van der Linden, Crispijn L van den Brand, Ido R van den Wijngaard, Roeline A Y de Beaufort, Naomi van der Linden, Korné Jellema
BACKGROUND: Emergency departments (EDs) worldwide face crowding, which hampers patient flow. In this study, the impact of a dedicated neurologist present at the ED on patient flow during out-of-office hours was assessed. METHODS: A cross-sectional, mixed methods study was undertaken at a Dutch ED, including a pre-post analysis of data of patients who had a primary neurological disease (n = 458) and staff surveys (n = 152). Descriptive statistics and content analysis were used for analyses...
January 12, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29330367/characterization-of-human-small-heat-shock-protein-hspb1-%C3%AE-crystallin-domain-localized-mutants-associated-with-hereditary-motor-neuron-diseases
#5
Stephen D Weeks, Lydia K Muranova, Michelle Heirbaut, Steven Beelen, Sergei V Strelkov, Nikolai B Gusev
Congenital mutations in human small heat shock protein HSPB1 (HSP27) have been linked to Charcot-Marie-Tooth disease, a commonly occurring peripheral neuropathy. Understanding the molecular mechanism of such mutations is indispensable towards developing future therapies for this currently incurable disorder. Here we describe the physico-chemical properties of the autosomal dominant HSPB1 mutants R127W, S135F and R136W. Despite having a nominal effect on thermal stability, the three mutations induce dramatic changes to quaternary structure...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330173/seasonal-variations-in-tuberculosis-diagnosis-among-hiv-positive-individuals-in-southern-africa-analysis-of-cohort-studies-at-antiretroviral-treatment-programmes
#6
Marie Ballif, Kathrin Zürcher, Stewart E Reid, Andrew Boulle, Matthew P Fox, Hans W Prozesky, Cleophas Chimbetete, Marcel Zwahlen, Matthias Egger, Lukas Fenner
OBJECTIVES: Seasonal variations in tuberculosis diagnoses have been attributed to seasonal climatic changes and indoor crowding during colder winter months. We investigated trends in pulmonary tuberculosis (PTB) diagnosis at antiretroviral therapy (ART) programmes in Southern Africa. SETTING: Five ART programmes participating in the International Epidemiology Database to Evaluate AIDS in South Africa, Zambia and Zimbabwe. PARTICIPANTS: We analysed data of 331 634 HIV-positive adults (>15 years), who initiated ART between January 2004 and December 2014...
January 11, 2018: BMJ Open
https://www.readbyqxmd.com/read/29328795/emerging-changing-fashion-trends-and-their-impact-on-conduct-of-anaesthesia
#7
Nadeem Zaidi
One of the innate features of human behaviour is to enhance personal image in order to look different from the rest of the crowd and to satisfy a need for individualism. People use different dress codes, body makeup and artificial gadgets to improve their personal and physical appearance. The main motive behind all these efforts is personal satisfaction, to appear attractive to others and to overcome phobias and complexes.
November 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29327041/common-constraints-limit-korean-and-english-character-recognition-in-peripheral-vision
#8
Yingchen He, MiYoung Kwon, Gordon E Legge
The visual span refers to the number of adjacent characters that can be recognized in a single glance. It is viewed as a sensory bottleneck in reading for both normal and clinical populations. In peripheral vision, the visual span for English characters can be enlarged after training with a letter-recognition task. Here, we examined the transfer of training from Korean to English characters for a group of bilingual Korean native speakers. In the pre- and posttests, we measured visual spans for Korean characters and English letters...
January 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29326528/taking-a-glance-at-anterior-crossbite-in-children-case-series
#9
Derya Ceyhan, Canan Akdik
Anterior crossbite is a malocclusion that takes place for various reasons, leads to major problems and may be fixed using various methods. This study aimed to provide an update regarding the methods used for anterior crossbite treatment presenting treatments of the removable active acrylic appliance with bite plane. Clinical examination of aged 9-15, seven healthy children who visited our clinic due to crowding and esthetic displeasure in anterior teeth indicated that one or more permanent maxillar incisor teeth were positioned behind of permanent mandibular incisor teeth...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326527/treatment-of-a-class-ii-malocclusion-with-deep-overbite-in-an-adult-patient-using-intermaxillary-elastics-and-spee-curve-controlling-with-reverse-and-accentuated-archwires
#10
Fabrício Pinelli Valarelli, Ronaldo Carniel, Paula Patrícia Cotrin-Silva, Mayara Paim Patel, Rodrigo Hermont Cançado, Karina Maria Salvatore Freitas, Marcos Roberto de Freitas
This paper aimed to describe the orthodontic treatment of an adult patient with the following characteristics: asymmetric Class II malocclusion, left subdivision, mandibular midline shifted to the left, mild mandibular anterior crowding, excessive overbite, 4-mm overjet, and a brachycephalic facial pattern. A 31-year-old male patient, treated with fixed preadjusted appliance with Roth prescription, with leveling and alignment NiTi archwire sequence. To correct the asymmetric Class II malocclusion, midline shift as well the overjet and overbite, intermaxillary elastics and accentuated and reversed stainless steel archwires were used, respectively...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29323426/vision-in-children-with-autism-spectrum-disorder-a-critical-review
#11
REVIEW
Julie-Anne Little
Autism spectrum disorder (ASD) is a common neurodevelopmental condition with approximately 1-2 per cent prevalence in the population. The condition has lifelong effects for the individual and family, and early intervention and management helps maximise quality of life and outcomes. Many studies of vision in ASD have attempted to link the behavioural and sensory deficits in ASD with underlying visual processing. From this work, it is clear that individuals with ASD 'see' and process the world differently, but there remain gaps in our understanding...
January 11, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29317382/accurate-influenza-monitoring-and-forecasting-using-novel-internet-data-streams-a-case-study-in-the-boston-metropolis
#12
Fred Sun Lu, Suqin Hou, Kristin Baltrusaitis, Manan Shah, Jure Leskovec, Rok Sosic, Jared Hawkins, John Brownstein, Giuseppe Conidi, Julia Gunn, Josh Gray, Anna Zink, Mauricio Santillana
BACKGROUND: Influenza outbreaks pose major challenges to public health around the world, leading to thousands of deaths a year in the United States alone. Accurate systems that track influenza activity at the city level are necessary to provide actionable information that can be used for clinical, hospital, and community outbreak preparation. OBJECTIVE: Although Internet-based real-time data sources such as Google searches and tweets have been successfully used to produce influenza activity estimates ahead of traditional health care-based systems at national and state levels, influenza tracking and forecasting at finer spatial resolutions, such as the city level, remain an open question...
January 9, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29316443/mechanism-and-determinants-of-amphipathic-helix-containing-protein-targeting-to-lipid-droplets
#13
Coline Prévost, Morris E Sharp, Nora Kory, Qingqing Lin, Gregory A Voth, Robert V Farese, Tobias C Walther
Cytosolic lipid droplets (LDs) are the main storage organelles for metabolic energy in most cells. They are unusual organelles that are bounded by a phospholipid monolayer and specific surface proteins, including key enzymes of lipid and energy metabolism. Proteins targeting LDs from the cytoplasm often contain amphipathic helices, but how they bind to LDs is not well understood. Combining computer simulations with experimental studies in vitro and in cells, we uncover a general mechanism for targeting of cytosolic proteins to LDs: large hydrophobic residues of amphipathic helices detect and bind to large, persistent membrane packing defects that are unique to the LD surface...
January 8, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29314757/machine-learning-for-identifying-randomized-controlled-trials-an-evaluation-and-practitioner-s-guide
#14
Iain Marshall, Anna Noel Storr, Joël Kuiper, James Thomas, Byron C Wallace
Machine learning (ML) algorithms have proven highly accurate for identifying Randomized Controlled Trials (RCTs), but are not used much in practice, in part because the best way to make use of the technology in a typical workflow is unclear. In this work we evaluate ML models for RCT classification (Support Vector Machines [SVMs], Convolutional Neural Networks [CNNs], and ensemble approaches). We trained and optimised SVM and CNN models on the titles and abstracts of the Cochrane Crowd RCT set. We evaluated the models on an external dataset (Clinical Hedges), allowing direct comparison with traditional database search filters...
January 4, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29314214/oral-and-craniofacial-manifestations-in-a-hunter-syndrome-patient-with-hematopoietic-stem-cell-transplantation-a-case-report
#15
Rafaela de Oliveira Torres, Andréa Vaz Braga Pintor, Fábio Ribeiro Guedes, Liana Bastos Freitas-Fernandes, Anneliese Lopes Barth, Dafne Dain Gandelman Horovitz, Ivete Pomarico Ribeiro de Souza
We described herein the oral and craniofacial features of a 7-year-old boy, diagnosed in utero with mucopolysaccharidosis II (MPS II), who was treated with hematopoietic stem cell transplantation (HSCT) at 70 days of age. The main oral clinical findings were the following: macroglossia, posterior cross-bite, crowding, pointed cuspid teeth, delayed tooth eruption, retained primary teeth, and enamel hypoplasia. The image examination showed: retention eruption, posterior primary teeth with short roots, absence of some permanent teeth, and stretching of the stylohyoid processes bilaterally...
January 4, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29313580/presenting-research-paper-learning-the-steps
#16
Sandeep B Bavdekar, Varun Anand, Shruti Vyas
For a beginner, presenting a research paper at a conference as a podium presentation can be a daunting task. She is required to choose an appropriate conference for presentation, prepare an abstract, prepare slides and the speech that goes parallel with the slides and train oneself to answer questions posed by the audience. She has also got to overcome the fear of speaking in public and conquer the phobia of encountering a hostile audience ready to shred her paper to pieces. This communication intends to provide useful tips on how to go about preparing and presenting a research paper...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29313308/noise-pollution-and-impact-on-children-health
#17
REVIEW
Alok Gupta, Anant Gupta, Khushbu Jain, Sweta Gupta
With rapid urbanization and life style changes, loud noise is omnipresent and has become a part of life. Indoor and outdoor environmental noise pollution have been documented as a serious health hazard with increasing adverse effects on fetus, infants, children, adolescents and adults. Noise induced hearing loss and non-auditory adverse effects due to noise pollution, are being increasingly diagnosed in all age groups including the fetus. Outdated motorized vehicles, machinery, increasing traffic, congested residential areas, crowded educational institutions and workplaces, unregulated commercial and industrial noise have become a source of noise pollution with long-term disability...
January 9, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29311622/dual-roles-of-trf1-in-tethering-telomeres-to-the-nuclear-envelope-and-protecting-them-from-fusion-during-meiosis
#18
Lina Wang, Zhaowei Tu, Chao Liu, Hongbin Liu, Philipp Kaldis, Zijiang Chen, Wei Li
Telomeres integrity is indispensable for chromosomal stability by preventing chromosome erosion and end-to-end fusions. During meiosis, telomeres attach to the inner nuclear envelope and cluster into a highly crowded microenvironment at the bouquet stage, which requires specific mechanisms to protect the telomeres from fusion. Here, we demonstrate that germ cell-specific knockout of a shelterin complex subunit, Trf1, results in arrest of spermatocytes at two different stages. The obliterated telomere-nuclear envelope attachment in Trf1-deficient spermatocytes impairs homologue synapsis and recombination, resulting in a pachytene-like arrest, while the meiotic division arrest might stem from chromosome end-to-end fusion due to the failure of recruiting meiosis specific telomere associated proteins...
January 8, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29310979/malassezia-species-in-students-from-universities-of-sabzevar-northeastern-iran
#19
H Moallaei, M J Namazi, J P Bouchara, S Pourhammed
BACKGROUND: Malassezia species, usually part of normal human skin microbiota, may also cause cutaneous infections, mainly pityriasis versicolor (PV) which may rapidly spread in crowded communities, particularly in students' dormitories and sport leisure centers. OBJECTIVE: Few studies have been conducted on PV in students in the Middle East. The present study was designed to determine prevalence of Malassezia species and related diseases in students from city of Sabzevar, Northeast Iran...
January 5, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29310585/factors-contributing-to-measles-transmission-during-an-outbreak-in-kamwenge-district-western-uganda-april-to-august-2015
#20
Fred Nsubuga, Lilian Bulage, Immaculate Ampeire, Joseph K B Matovu, Simon Kasasa, Patricia Tanifum, Alex Ario Riolexus, Bao-Ping Zhu
BACKGROUND: In April 2015, Kamwenge District, western Uganda reported a measles outbreak. We investigated the outbreak to identify potential exposures that facilitated measles transmission, assess vaccine effectiveness (VE) and vaccination coverage (VC), and recommend prevention and control measures. METHODS: For this investigation, a probable case was defined as onset of fever and generalized maculopapular rash, plus ≥1 of the following symptoms: Coryza, conjunctivitis, or cough...
January 8, 2018: BMC Infectious Diseases
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