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https://www.readbyqxmd.com/read/28743177/traditional-suburethral-sling-operations-for-urinary-incontinence-in-women
#1
REVIEW
Haroon Rehman, Carlos A Bezerra, Homero Bruschini, June D Cody, Patricia Aluko
BACKGROUND: Stress urinary incontinence constitutes a significant health and economic burden to society. Traditional suburethral slings are one of the surgical operations used to treat women with symptoms of stress urinary incontinence. OBJECTIVES: To determine the effects of traditional suburethral slings on stress or mixed incontinence in comparison with other management options. SEARCH METHODS: We searched the Cochrane Incontinence Group Specialised Register (searched 3 June 2010) and the reference lists of relevant articles...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28743151/-remifentanil-up2date-part-1
#2
Stefan Bushuven, Sascha Kreuer, Peter Kranke
Remifentanil is a short-acting opioid of high analgetic potency and superior controllability. It is widely used in day-case surgery, procedural sedation, for reduction of recovery-times and obstetrics and whenever excellent controllability of opioid effects is needed. Especially in combination with Propofol it is used for target-controlled infusion (TCI). The first part of the article provides readers with information about historical aspects, pharmacological characteristics, effects and side effects of remifentanil...
July 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28743096/osteoarthritis-with-permanent-dislocation-of-the-patella-treated-by-total-knee-arthroplasty-through-a-lateral-approach-a-report-of-two-cases
#3
Shuichi Fujiwara, Takafumi Hiranaka, Yuichi Hida, Shigeru Matsuda, Harunobu Uemoto
INTRODUCTION: Permanent dislocation of the patella (PDP) is a rare condition. In cases of PDP with tibiofemoral arthritis, total knee arthroplasty may be performed through a medial parapatellar approach with patellar realignment. In this article we present two cases of PDP with tibiofemoral osteoarthritis successfully treated via lateral approach TKA without any additional realignment procedure. We performed two total knee arthroplasties for PDP with lateral tibiofemoral arthritis through a lateral approach without any realignment procedure...
July 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28742984/single-versus-combined-immunoregulatory-approach-using-pd-1-and-ctla-4-modulators-in-controlling-sepsis
#4
Courtney P Rudick, David L Cornell, Devendra K Agrawal
Sepsis is a disease process characterized by an extreme inflammatory response followed by a period of severe immunosuppression. In recent years, there has been improved survival in the initial immune response during systemic inflammatory response syndrome, and compensatory anti-inflammatory response, yet is mostly unchanged with 18-30% mortality during the later stage of sepsis despite numerous Phase 3 clinical trials. Areas covered: This review article presents a critical evaluation of the most promising newer studies aimed at improving the immunosuppressive stage of sepsis...
July 25, 2017: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/28742983/should-adults-with-diabetes-mellitus-be-vaccinated-against-hepatitis-b-virus-a-systematic-review-of-diabetes-mellitus-and-the-progression-of-hepatitis-b-disease
#5
Zobair Younossi, Katrin Kochems, Marc de Ridder, Desmond Curran, Eveline M Bunge, Laurence de Moerlooze
Despite the burden of diabetes mellitus (DM), little is known about the role of this and other metabolic syndromes on the severity of hepatitis B virus (HBV) chronicity and liver disease progression. The value of hepatitis B vaccination and its impact on liver diseases and HCC has been largely demonstrated (ref), adult vaccination coverage is however suboptimal and DM diagnosis represents an opportunity for the HCP to discuss hepatitis B and other adult vaccinations. We performed a systematic literature search to identify studies (2000 to January 2017) describing liver disease progression among patients with HBV by DM status...
July 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28742974/chiropractic-curriculum-mapping-and-congruence-of-the-evidence-for-workplace-interventions-in-work-related-neck-pain
#6
Martin Frutiger, Peter Jeffery Tuchin
OBJECTIVE: The purpose of this study was to provide a best-synthesis summary of the literature for effective workplace health promotion interventions (WHPI) for work-related mechanical neck pain (MNP) and to determine the congruence between knowledge of WHPI for work-related MNP and coverage of MNP in the chiropractic postgraduate program at Macquarie University. METHODS: A literature review was undertaken to determine effective WHPI for work-related MNP. We searched Cochrane Library, PubMed, EMBASE, CINAHL, and PEDro (from 1991 to 2016) for systematic reviews and meta-analyses...
July 25, 2017: Journal of Chiropractic Education
https://www.readbyqxmd.com/read/28742972/stimuli-responsive-directional-vesicular-assembly-with-tunable-surface-functionality-and-impact-on-enzyme-inhibition
#7
Amrita Sikder, Debes Ray, Vinod Kumar Aswal, Suhrit Ghosh
The article describes self-assembly of a series of unsymmetrical bola-shape π-amphiphiles (NDI-1, NDI-1a, NDI-2, NDI-3 and NDI-4) consisting of a hydrophobic naphthalene-diimide (NDI) chromophore attached with a non-ionic hydrophilic wedge and an anionic head group in the two opposite arms of the central NDI. By design only a single hydrazide group is linked either on the ionic or non-ionic arm of the NDI. NDI-1 and NDI-1a are regioisomers differing only in the location of the hydrazide group, placed in the non-ionic or ionic arm, respectively...
July 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28742956/fluorescence-and-sensing-applications-of-graphene-oxide-and-graphene-quantum-dots-a-review
#8
Peng Zheng, Nianqiang Wu
Graphene oxide and graphene quantum dots are attractive fluorophores, which are inexpensive, non-toxic, photo-stable, water-soluble, biocompatible and environmentally friendly. They find extensive applications in fluorescent biosensors and chemi-sensors, in which they either serve as fluorophores or quenchers. As fluorophores, they display the tunable photoluminescence emission and the "Giant Red-Edge Effect". As quenchers, they exhibit a remarkable quenching efficiency via either electron transfer or Förster resonance energy transfer (FRET) process...
July 25, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28742954/carbon-dioxide-elimination-by-cardiomyocytes-a-tale-of-high-carbonic-anhydrase-activity-and-membrane-permeability
#9
EDITORIAL
Erik R Swenson
Life as a multicellular organism requires a heart with a coordinated contractile activity that must never cease, and in this regard, it is very much like the brain with a high mass-specific 'resting' metabolic rate. To maintain this constant activity requires a high rate of oxygen consumption and resultant carbon dioxide generation and, pari passu, the rapid exchange of large amounts of these gases with capillary blood. While oxygen has been far more the focus of the two gases in cardiac physiology, the work of Arias-Hidalgo et al (1) in this issue of the journal offers new insights and better understanding of how CO2 uniquely traverses its path from production in the mitochondria to the capillary blood, and does so with much smaller driving gradients than necessary for oxygen...
July 25, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28742951/providing-better-access-to-organs-a-comprehensive-overview-of-organ-access-initiatives-from-the-asts-proactor-task-force
#10
M J Hobeika, C M Miller, T L Pruett, K A Gifford, J E Locke, A M Cameron, M J Englesbe, C S Kuhr, J F Magliocca, K R McCune, K L Mekeel, S J Pelletier, A L Singer, D L Segev
The American Society of Transplant Surgeons (ASTS) PROviding better Access To Organs (PROACTOR) Task Force was created to inform ongoing ASTS organ access efforts. Task force members were charged with comprehensively cataloguing current organ access activities and organizing them according to stakeholder type. This White Paper summarizes the task force findings and makes recommendations for future ASTS organ access initiatives. This article is protected by copyright. All rights reserved.
July 25, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28742948/microbial-metabolites-and-graft-versus-host-disease
#11
Mary Riwes, Pavan Reddy
The health of mammals is a reflection of the diversity and composition of the intestinal microbiota. Alterations in the composition and functions of the intestinal microbiota have been implicated in multiple disease processes. The impact of the microbiota in health and disease is in part a function of the nutrient processing and release of metabolites. Recent studies have uncovered a major role for microbial metabolites in the function of the host immune system by which they influence disease processes such as acute graft versus host disease (GVHD), which is the main complication of allogeneic hematopoietic cell transplantation (allo-HCT)...
July 25, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28742946/the-association-between-obesity-and-academic-performance-in-youth-a-systematic-review
#12
REVIEW
C C A Santana, J O Hill, L B Azevedo, T Gunnarsdottir, W L Prado
Previous studies have found that obesity could influence academic performance. The aim of this study was to systematically review the scientific evidence on the association between obesity and academic performance in school children. A systematic review of English articles was undertaken by using databases PubMed/Medline, ERIC, LILACS, SciELO and Web of Science. Cross-sectional and longitudinal studies examining the association between obesity and academic performance in children and adolescents, published between January 1990 and December 2016, were included...
July 25, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28742942/regulation-of-transposable-elements-interplay-between-te-encoded-regulatory-sequences-and-host-specific-trans-acting-factors-in-drosophila-melanogaster
#13
Ana Marija Jakšić, Robert Kofler, Christian Schlötterer
Transposable elements (TEs) are mobile genetic elements that can move around the genome and their expression is one precondition for this mobility. Because the insertion of TEs in new genomic positions is largely deleterious, the molecular mechanisms for transcriptional suppression have been extensively studied. In contrast, very little is known about their primary transcriptional regulation. Here, we characterize the expression dynamics of TE families in Drosophila melanogaster across a broad temperature range (13-29°C)...
July 25, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28742939/disparate-peroxisome-related-defects-in-arabidopsis-pex6-and-pex26-mutants-link-peroxisomal-retrotranslocation-and-oil-body-utilization
#14
Kim L Gonzalez, Wendell A Fleming, Yun-Ting Kao, Zachary J Wright, Savina V Venkova, Meredith J Ventura, Bonnie Bartel
Catabolism of fatty acids stored in oil bodies is essential for Arabidopsis seed germination and seedling development. This fatty acid breakdown occurs in peroxisomes, organelles that sequester oxidative reactions. Import of peroxisomal enzymes is facilitated by peroxins including PEX5, a receptor that delivers cargo proteins from the cytosol to the peroxisomal matrix. After cargo delivery, a complex of the PEX1 and PEX6 ATPases and the PEX26 tail-anchored membrane protein removes ubiquitinated PEX5 from the peroxisomal membrane...
July 25, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28742938/sexes-in-gynodioecious-geranium-sylvaticum-do-not-differ-in-their-isotopic-signature-or-photosynthetic-capacity
#15
Sandra Varga, Minna-Maarit Kytöviita
In gynodioecious plants, females are expected to produce more or better seeds than hermaphrodites in order to be maintained within the same population. Even though rarely measured, higher seed production can be achieved through differences in physiology. In this work, we measured sexual dimorphism in several physiological traits in the gynodioecious plant Geranium sylvaticum. Photosynthetic rate, stomatal conductivity, transpiration rate, water use efficiency and isotopic signatures were measured in plants growing in two habitats differing in light availability...
July 25, 2017: Plant Biology
https://www.readbyqxmd.com/read/28742937/models-for-discovery-of-targeted-therapy-in-genetic-epileptic-encephalopathies
#16
REVIEW
Snezana Maljevic, Christopher A Reid, Steven Petrou
Epileptic encephalopathies are severe disorders emerging in the first days to years of life that commonly include refractory seizures, various types of movement disorders, and different levels of developmental delay. In recent years, many de novo occurring variants have been identified in individuals with these devastating disorders. To unravel disease mechanisms the functional impact of detected variants associated with epileptic encephalopathies is investigated in a range of cellular and animal models. This review addresses efforts to advance and use such models to identify specific molecular and cellular targets for the development of novel therapies...
July 25, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28742936/benefits-and-limitations-of-belatacept-in-4-hand-transplanted-patients
#17
J Grahammer, A Weissenbacher, B G Zelger, B Zelger, C Boesmueller, M Ninkovic, A Mühlbacher, I Peschel, G Brandacher, D Öfner, S Schneeberger
Belatacept (CTLA4Ig) is an emerging treatment in kidney transplantation. Lack of nephrotoxicity and possibly an inhibitory effect on the development of donor specific antibodies (DSA) make it an interesting agent in hand transplantation. In order to reduce CNI immunosuppression and preserve kidney function, we have added belatacept to the therapeutic regimen of 4 hand transplanted patients at month 4, at 6, 9, and 13 years after hand/forearm transplantation. Patients received 5mg/kg belatacept every 2 weeks, the dosing interval was extended to 4 weeks after 5 applications...
July 25, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28742935/response-to-telling-the-whole-story-about-simulation-based-education
#18
Christopher W H Yau, Elena Pizzo, Steve Morris, David E Odd, Cathy Winter, Timothy J Draycott
We thank Barsuk et al. for their letter, "Telling the whole story about simulation-based education" (1). We acknowledge that our paper, "The cost of local, multi-professional obstetric emergencies training"(2), focussed on the cost of training and did not elaborate on cost savings, value for money or return on investment (ROI). The authors' call for a ROI analysis is welcome. Others have estimated the potential savings of obstetric training (3). This article is protected by copyright. All rights reserved.
July 25, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28742933/gene-expression-is-more-strongly-influenced-by-age-than-caste-in-the-ant-lasius-niger
#19
Eric R Lucas, Jonathan Romiguier, Laurent Keller
Phenotypic plasticity, where a single genome can give rise to different phenotypes, underlies many remarkable features of the natural world and occurs in a wide range of organisms. Understanding the transcriptional differences that underlie plastic phenotypes remains a major unsolved problem in biology. In many ants, females can develop into either queens or workers, two phenotypes with different morphology, behaviour and longevity. In comparison to workers, queens are larger, more fecund and longer-lived. Here, we study gene expression differences between queens and workers in the ant Lasius niger...
July 25, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28742931/dynamics-of-lipids-and-metabolites-during-the-cell-cycle-of-chlamydomonas-reinhardtii
#20
Jessica Jüppner, Umarah Mubeen, Andrea Leisse, Camila Caldana, Henrike Brust, Martin Steup, Marion Herrmann, Dirk Steinhauser, Patrick Giavalisco
Metabolites and lipids are the final products of enzymatic processes, distinguishing the different cellular functions and activities of single cells or whole tissues. Understanding these cellular functions within a well-established model system, requires a systemic collection of molecular and physiological information. In the current report, the green algae Chlamydomonas reinhardtii was selected to establish a comprehensive workflow for the detailed multi-omics analysis of a synchronously growing cell culture system...
July 25, 2017: Plant Journal: for Cell and Molecular Biology
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