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https://www.readbyqxmd.com/read/29330614/effect-of-ancymidol-on-cell-wall-metabolism-in-growing-maize-cells
#1
J Mabel Hernández-Altamirano, Asier Largo-Gosens, Romina Martínez-Rubio, Diego Pereda, Jesús M Álvarez, José L Acebes, Antonio Encina, Penélope García-Angulo
Ancymidol inhibits the incorporation of cellulose into cell walls of maize cell cultures in a gibberellin-independent manner, impairing cell growth; the reduction in the cellulose content is compensated with xylans. Ancymidol is a plant growth retardant which impairs gibberellin biosynthesis. It has been reported to inhibit cellulose synthesis by tobacco cells, based on its cell-malforming effects. To ascertain the putative role of ancymidol as a cellulose biosynthesis inhibitor, we conducted a biochemical study of its effect on cell growth and cell wall metabolism in maize cultured cells...
January 12, 2018: Planta
https://www.readbyqxmd.com/read/29328980/consequence-of-intraventricular-hemorrhage-on-neurovascular-coupling-evoked-by-speech-syllables-in-preterm-neonates
#2
Mahdi Mahmoudzadeh, Ghislaine Dehaene-Lambertz, Guy Kongolo, Marc Fournier, Sabrina Goudjil, Fabrice Wallois
Intraventricular Hemorrhage (IVH) is the leading cause of neurological and cognitive impairment in preterm neonates with an incidence that increases with increasing prematurity. In the present study, we tested how preterm neonates with IVH react to external stimulation (i.e. speech syllables). We compared their neural responses measured by electroencephalography (EEG), and hemodynamic responses measured by functional near-infrared spectroscopy (fNIRS), with those of healthy preterms. A neural response to syllables was observed in these infants, but did not induce a vascular response in contrast with healthy neonates...
January 5, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29324342/peramivir-conjugates-as-orally-available-agents-against-influenza-h275y-mutant
#3
Peng-Cheng Wang, Din-Chi Chiu, Jia-Tsrong Jan, Wen-I Huang, Yin-Chen Tseng, Ting-Ting Li, Ting-Jen Cheng, Keng-Chang Tsai, Jim-Min Fang
Peramivir is an efficacious neuraminidase (NA) inhibitor for treatment of influenza by intravenous administration. However, the efficacy of peramivir toward the H275Y mutant is appreciably reduced. To address this drawback, conjugation of peramivir with caffeic acid is devised in this study to enhance the binding affinity with neuraminidases. The C2-OH group of peramivir is elaborated to link with caffeate derivatives, giving the desired conjugates 8 and 9 that possess potent NA inhibitory activity against both wild-type and H275Y viruses with the IC50 values in nanomolar range...
December 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29323266/aif-loss-deregulates-hematopoiesis-and-reveals-different-adaptive-metabolic-responses-in-bone-marrow-cells-and-thymocytes
#4
Lauriane Cabon, Audrey Bertaux, Marie-Noëlle Brunelle-Navas, Ivan Nemazanyy, Laurianne Scourzic, Laure Delavallée, Laura Vela, Mathieu Baritaud, Sandrine Bouchet, Cécile Lopez, Vu Quang Van, Kevin Garbin, Danielle Chateau, Françoise Gilard, Marika Sarfati, Thomas Mercher, Olivier A Bernard, Santos A Susin
Mitochondrial metabolism is a tightly regulated process that plays a central role throughout the lifespan of hematopoietic cells. Herein, we analyze the consequences of the mitochondrial oxidative phosphorylation (OXPHOS)/metabolism disorder associated with the cell-specific hematopoietic ablation of apoptosis-inducing factor (AIF). AIF-null (AIF-/Y ) mice developed pancytopenia that was associated with hypocellular bone marrow (BM) and thymus atrophy. Although myeloid cells were relatively spared, the B-cell and erythroid lineages were altered with increased frequencies of precursor B cells, pro-erythroblasts I, and basophilic erythroblasts II...
January 11, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29320718/adiposity-and-family-history-of-type-2-diabetes-in-an-admixed-population-of-adolescents-associations-with-insulin-sensitivity-beta-cell-function-and-hepatic-insulin-extraction-in-brams-study
#5
Daniella F Camilo, Ana Carolina J Vasques, Keila Hayashi, Andrea Tura, Cleliani de Cassia da Silva, Mariana P Zambon, Maria Ângela R de G Monteiro Antônio, Bruno Geloneze
AIMS: Insulin resistance and beta-cell dysfunction manifest differently across racial/ethnic groups, and there is a lack of knowledge regarding the pathophysiology of type 2 diabetes mellitus (T2DM) for ethnically admixed adolescents. This study aimed to investigate the influence of adiposity and family history (FH) of T2DM on aspects of insulin sensitivity, beta-cell function, and hepatic insulin extraction in Brazilian adolescents. METHODS: A total of 82 normoglycemic adolescents were assessed...
January 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29319133/the-assessment-of-testosterone-and-radioisotopic-index-of-bone-metabolism-and-bone-mineral-density-in-men-with-testosterone-deficiency-after-one-year-of-testosterone-therapy
#6
Wieslaw Tryniszewski, Grzegorz Kamiński, Zbigniew Maziarz, Michal Nowak, Mariusz Gadzicki, Maciej Radek
BACKGROUND: Testosterone deficiency in men is characterized by typical symptoms of hypogonadism and negative influence on the preservation of bone mass. In this study, we analysed the relationship between testosterone concentration and bone metabolism. Moreover, we assessed the impact of one-year compensation of testosterone deficiency in elderly men on bone metabolism and bone mineral density. Radioisotopic methods of bone metabolism assessment provide new research opportunities. MATERIALS AND METHODS: Men with total testosterone concentration (TT) ≤ 3 ng/ml were included into this study...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29314731/regulation-of-amino-acid-metabolism-and-alpha-cell-proliferation-by-glucagon
#7
REVIEW
Yoshitaka Hayashi, Yusuke Seino
Both glucagon and GLP-1 are produced from proglucagon through proteolytic cleavage. Blocking glucagon action increases the circulating levels of glucagon and GLP-1, reduces the blood glucose level and induces the proliferation of islet alpha cells. Glucagon blockade also suppresses hepatic amino acid catabolism and increases the serum amino acid level. In animal models defective in both glucagon and GLP-1, the blood glucose level is not reduced, indicating that GLP-1 is required for glucagon blockade to reduce the blood glucose level...
January 3, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29309862/escalation-of-liver-malfunctioning-a-step-toward-herbal-awareness
#8
REVIEW
Bushra Sultana, Sadaf Yaqoob, Zohaib Zafar, Haq Nawaz Bhatti
ETHNOPHARMACOLOGICAL RELEVANCE: About 2 to 5 % of the world's population is suffering from liver toxicity including Pakistan with the second highest rate of hepatitis prevalence. Liver is a vital body organ which not only performs metabolic activities but also aids in detoxification, storage and digestion of food. Now a day's malnutrition, alcohol consumption and drug addiction are major causes of liver diseases throughout the world. In fact, there is no possible outcome to compensate liver malfunction for long term, and transplantation of liver is the only option left after the irretrievable injury of hepatic function...
January 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29307724/the-effect-of-metabolic-alkalosis-on-the-ventilatory-response-in-healthy-subjects
#9
E Oppersma, J Doorduin, J G van der Hoeven, P H Veltink, H W H van Hees, L M A Heunks
BACKGROUND: Patients with acute respiratory failure may develop respiratory acidosis. Metabolic compensation by bicarbonate production or retention results in posthypercapnic alkalosis with an increased arterial bicarbonate concentration. The hypothesis of this study was that elevated plasma bicarbonate levels decrease respiratory drive and minute ventilation. METHODS: In an intervention study in 10 healthy subjects the ventilatory response using a hypercapnic ventilatory response (HCVR) test was assessed, before and after administration of high dose sodium bicarbonate...
January 4, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29305337/serum-adiponectin-levels-predict-acute-coronary-syndrome-acs-in-patients-with-severe-carotid-stenosis
#10
Luca Liberale, Federico Carbone, Maria Bertolotto, Aldo Bonaventura, Alessandra Vecchié, François Mach, Fabienne Burger, Aldo Pende, Giovanni Spinella, Bianca Pane, Domenico Palombo, Franco Dallegri, Fabrizio Montecucco
As endocrine organ, adipose tissue may modulate inflammatory response by releasing a wide range of mediators, known as adipocytokines. Due to the complex balance between pro- and anti-inflammatory activity their pathophysiological and prognostic role in cardiovascular (CV) diseases still remains debated. Here, we consider the potential associations of circulating adipocytokines adiponectin, leptin and their ratio (LAR), with metabolic and inflammatory profiles in 217 patients with severe carotid stenosis. A prospective analysis investigating their predictive role toward acute coronary syndromes (ACS) was also drawn over a 12-month follow-up period...
January 2, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29302276/haemoglobin-mediated-response-to-hyper-thermal-stress-in-the-keystone-species-daphnia-magna
#11
Maria Cuenca Cambronero, Bettina Zeis, Luisa Orsini
Anthropogenic global warming has become a major geological and environmental force driving drastic changes in natural ecosystems. Due to the high thermal conductivity of water and the effects of temperature on metabolic processes, freshwater ecosystems are among the most impacted by these changes. The ability to tolerate changes in temperature may determine species long-term survival and fitness. Therefore, it is critical to identify coping mechanisms to thermal and hyper-thermal stress in aquatic organisms...
January 2018: Evolutionary Applications
https://www.readbyqxmd.com/read/29289786/oxidant-antioxidant-balance-and-tolerance-against-oxidative-stress-in-pioneer-and-non-pioneer-tree-species-from-the-remaining-atlantic-forest
#12
Marisia Pannia Esposito, Ricardo Keiichi Nakazato, Andrea Nunes Vaz Pedroso, Marcos Enoque Leite Lima, Maurílio Assis Figueiredo, Adriana Pedrosa Diniz, Alessandra Rodrigues Kozovits, Marisa Domingos
The extensive land occupation in Southeast Brazil has resulted in climatic disturbances and environmental contamination by air pollutants, threatening the Atlantic forest remnants that still exist in that region. Based on previous results, we assumed that pioneer tree species are potentially more tolerant against environmental oxidative stress than non-pioneer tree species from that Brazilian biome. We also assumed that reactive oxygen species (ROS) are accumulated in higher proportions in leaves of non-pioneer trees, resulting in changes in the oxidant-antioxidant balance and in more severe oxidative damage at the cellular level than in the leaves of pioneer trees...
December 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29289652/cellular-mechanisms-of-metabolic-syndrome-related-atrial-decompensation-in-a-rat-model-of-hfpef
#13
Felix Hohendanner, David Bode, Uwe Primessnig, Tim Guthof, Rafael Doerr, Sarah Jeuthe, Sophie Reimers, Kun Zhang, Doris Bach, Paulina Wakula, Burkert M Pieske, Frank R Heinzel
Heart failure (HF) with preserved ejection fraction (HFpEF) is present in about 50% of HF patients. Atrial remodeling is common in HFpEF and associated with increased mortality. We postulate that atrial remodeling is associated with atrial dysfunction in vivo related to alterations in cardiomyocyte Calcium (Ca) signaling and remodeling. We examined atrial function in vivo and Ca transients (CaT) (Fluo4-AM, field stim) in atrial cardiomyocytes of ZSF-1 rats without (Ln; lean hypertensive) and with metabolic syndrome (Ob; obese, hypertensive, diabetic) and HFpEF...
December 28, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29284198/signals-from-the-south-humpback-whales-carry-messages-of-antarctic-sea-ice-ecosystem-variability
#14
Susan M Bengtson Nash, Juliana Castrillon, Pascale Eisenmann, Brian Fry, Jon D Shuker, Roger A Cropp, Amanda Dawson, Anders Bignert, Pernilla Bohlin-Nizzetto, Courtney A Waugh, Bradley J Polkinghorne, Greta Dalle Luche, David McLagan
Southern hemisphere humpback whales (Megaptera novaeangliae) rely on summer prey abundance of Antarctic krill (Euphausia superba) to fuel one of the longest-known mammalian migration on the planet. It is hypothesised that this species, already adapted to endure metabolic extremes, will be one of the first Antarctic consumers to show measurable physiological change in response to fluctuating prey availability in a changing climate; and as such, a powerful sentinel candidate for the Antarctic sea-ice ecosystem...
December 28, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29281766/temperature-driven-selection-on-metabolic-traits-increases-the-strength-of-an-algal-grazer-interaction-in-naturally-warmed-streams
#15
C-Elisa Schaum, Richard Ffrench-Constant, Chris Lowe, Jón S Ólafsson, Daniel Padfield, Gabriel Yvon-Durocher
Trophic interactions are important determinants of the structure and functioning of ecosystems. As the metabolism and consumption rates of ectotherms increase sharply with temperature, there are major concerns that global warming will increase the strength of trophic interactions, destabilizing food webs, and altering ecosystem structure and function. We used geothermally warmed streams that span an 11°C temperature gradient to investigate the interplay between temperature-driven selection on traits related to metabolism and resource acquisition, and the interaction strength between the keystone gastropod grazer, Radix balthica, and a common algal resource...
December 27, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29274979/effects-of-prepartum-dietary-cation-anion-difference-and-source-of-vitamin-d-in-dairy-cows-vitamin-d-mineral-and-bone-metabolism
#16
R M Rodney, N Martinez, E Block, L L Hernandez, P Celi, C D Nelson, J E P Santos, I J Lean
Pregnant Holstein cows, 28 nulliparous and 51 parous, were blocked by parity and milk yield and randomly allocated to receive diets that differed in dietary cation-anion difference (DCAD), +130 or -130 mEq/kg, and supplemented with either calcidiol or cholecalciferol at 3 mg/11 kg of dry matter from 255 d of gestation until parturition. Blood was sampled thrice weekly prepartum, and on d 0, 1, 2, 3, 6, 9, 12, 15, 18, 21, 24, 27, and 30 postpartum to evaluate effects of the diets on vitamin D, mineral and bone metabolism, and acid-base status...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29260593/determinants-of-glucose-metabolism-and-the-role-of-npy-in-the-progression-of-insulin-resistance-in-chronic-migraine
#17
Zeynep Oşar Siva, Derya Uluduz, Fatma Ela Keskin, Feyza Erenler, Huriye Balcı, Uğur Uygunoğlu, Sabahattin Saip, Baki Göksan, Aksel Siva
Background Chronic migraine has a well-documented association with increased insulin resistance and metabolic syndrome. The hypothalamus may play a role in the progression of insulin resistance in chronic migraine through the regulation of orexigenic peptides such as neuropeptide Y. Insulin resistance may lead to increased risk of future type 2 diabetes mellitus in patients with chronic migraine, which is more likely to occur if other pathogenetic defects of type 2 diabetes mellitus, such as impaired pancreatic β-cell functions and defects in intestinal glucagon-like peptide-1 secretion after meals...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29258206/the-dual-antioxidant-prooxidant-effect-of-eugenol-and-its-action-in-cancer-development-and-treatment
#18
REVIEW
Daniel Pereira Bezerra, Gardenia Carmen Gadelha Militão, Mayara Castro de Morais, Damião Pergentino de Sousa
The formation of reactive oxygen species (ROS) during metabolism is a normal process usually compensated for by the antioxidant defense system of an organism. However, ROS can cause oxidative damage and have been proposed to be the main cause of age-related clinical complications and diseases such as cancer. In recent decades, the relationship between diet and cancer has been more studied, especially with foods containing antioxidant compounds. Eugenol is a natural compound widely found in many aromatic plant species, spices and foods and is used in cosmetics and pharmaceutical products...
December 17, 2017: Nutrients
https://www.readbyqxmd.com/read/29250032/involvement-of-amylin-and-leptin-in-the-development-of-projections-from-the-area-postrema-to-the-nucleus-of-the-solitary-tract
#19
Kathrin Abegg, Andreas Hermann, Christina N Boyle, Sebastien G Bouret, Thomas A Lutz, Thomas Riediger
The area postrema (AP) and the nucleus of the solitary tract (NTS) are important hindbrain centers involved in the control of energy homeostasis. The AP mediates the anorectic action and the inhibitory effect on gastric emptying induced by the pancreatic hormone amylin. Amylin's target cells in the AP project to the NTS, an integrative relay center for enteroceptive signals. Perinatal hormonal and metabolic factors influence brain development. A postnatal surge of the adipocyte-derived hormone leptin represents a developmental signal for the maturation of projections between hypothalamic nuclei controlling energy balance...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29248678/nitric-oxide-promotes-light-initiated-seed-germination-by-repressing-pif1-expression-and-stabilizing-hfr1
#20
Ruijing Li, Yujie Jia, Lijuan Yu, Wenjuan Yang, Zhen Chen, Haiying Chen, Xiangyang Hu
Seed germination is a crucial stage in the life cycle of plants and is tightly controlled by internal and external signals. Phytochrome photoreceptors perceive light stimulation to promote seed germination. Previous studies have shown that PHYTOCHROME-INTERACTION FACTOR 1 (PIF1) is a negative regulatory factor and represses seed germination, while LONG HYPOCOTYL IN FAR-RED (HFR1) sequesters PIF1 by forming a heterodimer to relieve the inhibitory effect of seed germination during the initial phase. Nitric oxide (NO) has been reported to break seed dormancy, but the underlying mechanism is not well understood...
December 5, 2017: Plant Physiology and Biochemistry: PPB
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