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Metabolic compensation

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https://www.readbyqxmd.com/read/29777783/accelerated-lipid-catabolism-and-autophagy-are-cancer-survival-mechanisms-under-inhibited-glutaminolysis
#1
Anna Halama, Michal Kulinski, Shaima S Dib, Shaza B Zaghlool, Kodappully S Siveen, Ahmad Iskandarani, Jonas Zierer, Kirti S Prabhu, Noothan J Satheesh, Aditya M Bhagwat, Shahab Uddin, Gabi Kastenmüller, Olivier Elemento, Steven S Gross, Karsten Suhre
Suppressing glutaminolysis does not always induce cancer cell death in glutamine dependent tumors because cells may switch to alternative energy sources. To reveal compensatory metabolic pathways, we investigated the metabolome-wide cellular response to inhibited glutaminolysis in cancer cells. Glutaminolysis inhibition with C.968 suppressed cell proliferation but was insufficient to induce cancer cell death. We found that lipid catabolism was activated as a compensation for glutaminolysis inhibition. Accelerated lipid catabolism, together with oxidative stress induced by glutaminolysis inhibition, triggered autophagy...
May 16, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29773783/cholesteryl-ester-storage-disease-fatal-outcome-without-causal-therapy-in-a-female-patient-with-the-preventable-sequelae-of-progressive-liver-disease-after-many-years-of-mild-symptoms
#2
Ali Canbay, Meike N Müller, Stathis Philippou, Guido Gerken, Andreas Tromm
BACKGROUND Cholesteryl ester storage disease (CESD), also known as lysosomal acid lipase deficiency (LAL-D), is a rare autosomal-recessive inheritable lysosomal storage disease. Since 2015, a causal treatment with sebelipase alfa, which replaces the missing LAL enzyme, has been approved. We report a fatal course of LAL-D in a female patient. CASE REPORT In 1979, CESD was first diagnosed in a 13-year-old female with marked hepatomegaly. At that time, no specific treatment for CESD was available and the spontaneous course of the disease had to be awaited...
May 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29773188/the-toxic-effect-of-gallic-acid-on-biochemical-factors-viability-and-proliferation-of-rat-bone-marrow-mesenchymal-stem-cells-was-compensated-by-boric-acid
#3
Mohammad Hussein Abnosi, Somayeh Yari
OBJECTIVE: Gallic acid (GA) and boron are found in many plants. Our previous studies showed 6 ng/ml boric acid (BA) had positive effect on biochemistry of rat bone marrow mesenchymal stem cells (MSCs) and their osteogenic differentiation. Therefore, we investigate the effect of different doses of GA alone and in the presence of BA on MSCs. MATERIALS AND METHODS: the viability of MSCs was assayed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and trypan blue at 12, 24 and 36 h in presence of different concentration of GA...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29764512/mutational-analysis-of-two-residues-in-the-dyrk-homology-box-of-the-protein-kinase-dyrk1a
#4
Esti Wahyu Widowati, Simone Bamberg-Lemper, Walter Becker
OBJECTIVE: Dual specificity tyrosine phosphorylation-regulated kinases (DYRK) contain a characteristic sequence motif (DYRK homology box, DH box) that is located N-terminal of the catalytic domain and supports the autophosphorylation of a conserved tyrosine during maturation of the catalytic domain. Two missense mutations in the DH box of human DYRK1B were recently identified as causative of a rare familiar form of metabolic syndrome. We have recently shown that these amino acid exchanges impair maturation of the kinase domain...
May 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29761427/the-importance-of-experimental-design-quality-assurance-and-control-in-plant-metabolomics-experiments
#5
Marina C M Martins, Camila Caldana, Lucia Daniela Wolf, Luis Guilherme Furlan de Abreu
The output of metabolomics relies to a great extent upon the methods and instrumentation to identify, quantify, and access spatial information on as many metabolites as possible. However, the most modern machines and sophisticated tools for data analysis cannot compensate for inappropriate harvesting and/or sample preparation procedures that modify metabolic composition and can lead to erroneous interpretation of results. In addition, plant metabolism has a remarkable degree of complexity, and the number of identified compounds easily surpasses the number of samples in metabolomics analyses, increasing false discovery risk...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29743239/human-dhea-sulfation-requires-direct-interaction-between-paps-synthase-2-and-dhea-sulfotransferase-sult2a1
#6
Jonathan W Mueller, Jan Idkowiak, Tarsis F Gesteira, Cecilia Vallet, Rebecca Hardman, Johannes van den Boom, Vivek Dhir, Shirley K Knauer, Edina Rosta, Wiebke Arlt
The high-energy sulfate donor 3'-phosphoadenosine-5'-phosphosulfate (PAPS), generated by human PAPS synthase isoforms PAPSS1 and PAPSS2, is required for all human sulfation pathways. Sulfotransferase SULT2A1 uses PAPS for sulfation of the androgen precursor dehydroepiandrosterone (DHEA), thereby reducing downstream activation of DHEA to active androgens. Human PAPSS2 mutations manifest with undetectable DHEA sulfate, androgen excess and metabolic disease, suggesting that ubiquitous PAPSS1 cannot compensate for deficient PAPSS2 in supporting DHEA sulfation...
May 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29743073/parallel-substrate-supply-and-ph-stabilization-for-optimal-screening-of-e-coli-with-the-membrane-based-fed-batch-shake-flask
#7
P Philip, D Kern, J Goldmanns, F Seiler, A Schulte, T Habicher, J Büchs
BACKGROUND: Screening in the fed-batch operation mode is essential for biological cultivations facing challenges as oxygen limitation, osmotic inhibition, catabolite repression, substrate inhibition or overflow metabolism. As a screening tool on shake flask level, the membrane-based fed-batch shake flask was developed. While a controlled supply of a substrate was realized with the in-built membrane tip, the possibilities for replenishing nutrients and stabilizing pH values was not yet exploited...
May 9, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29737882/a-peripheral-blood-transcriptome-biomarker-test-to-diagnose-functional-recovery-potential-in-advanced-heart-failure
#8
Mario C Deng
Heart failure (HF) is a complex clinical syndrome that causes systemic hypoperfusion and failure to meet the body's metabolic demands. In an attempt to compensate, chronic upregulation of the sympathetic nervous system and renin-angiotensin-aldosterone leads to further myocardial injury, HF progression and reduced O2 delivery. This triggers progressive organ dysfunction, immune system activation and profound metabolic derangements, creating a milieu similar to other chronic systemic diseases and presenting as advanced HF with severely limited prognosis...
May 8, 2018: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29729151/subclinical-hypothyroidism-in-patients-with-non-alcoholic-fatty-liver-disease-at-the-background-of-carbohydrate-metabolism-disorders
#9
Snizhana V Feisa, Ivan V Chopei
OBJECTIVE: Introduction: The prevalence of non-alcoholic fatty liver disease (NAFLD) is 25-30% in the general population and more than 75% among patients with carbohydrate metabolism disorders. One in six patients with NAFLD has concomitant subclinical hypothyroidism. The aim is to compare lipid and carbohydrate metabolism states in patients with NAFLD depending on the functional state of the thyroid gland. PATIENTS AND METHODS: Materials and methods:215 patients with NAFLD and type 2 diabetes mellitus (T2-DM) or pre-diabetes (PD) were involved in study and devided into 6 groups according to the functional state of the thyroid gland...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29727016/metabolic-stress-dependent-regulation-of-the-mitochondrial-biogenic-molecular-response-to-high-intensity-exercise-in-human-skeletal-muscle
#10
M Fiorenza, T P Gunnarsson, M Hostrup, F M Iaia, F Schena, H Pilegaard, J Bangsbo
KEY POINTS: Low-volume high-intensity exercise training promotes muscle mitochondrial adaptations that resemble the ones associated with high-volume moderate-intensity exercise training. These training-induced mitochondrial adaptations stem from the cumulative effects of transient transcriptional responses to each acute exercise bout. However, whether metabolic stress is a key mediator of the acute molecular responses to high-intensity exercise is still incompletely understood. Herein we show that, by comparing different work-matched low-volume high-intensity exercise protocols, more marked metabolic perturbations were associated with enhanced mitochondrial biogenesis-related muscle mRNA responses...
May 4, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29723273/distinct-roles-for-rev-erb%C3%AE-and-rev-erb%C3%AE-in-oxidative-capacity-and-mitochondrial-biogenesis-in-skeletal-muscle
#11
Ariadna Amador, Sean Campbell, Melissa Kazantzis, Gary Lan, Thomas P Burris, Laura A Solt
The nuclear receptors REV-ERBα and REV-ERBβ have been demonstrated to be core members of the circadian clock and participate in the regulation of a diverse set of metabolic functions. Due to their overlapping tissue expression patterns and gene expression profiles, REV-ERBβ is thought to be redundant to REV-ERBα. Recent work has highlighted REV-ERBα's role in the regulation of skeletal muscle oxidative capacity and mitochondrial biogenesis. Considering the similarity between the REV-ERBs and the hypothesized overlap in function, we sought to determine whether REV-ERBβ-deficiency presented with a similar skeletal muscle phenotype as REV-ERBα-deficiency...
2018: PloS One
https://www.readbyqxmd.com/read/29720730/a-proteomic-analysis-of-an-in-vitro-knock-out-of-mir-200c
#12
Bojan Ljepoja, Jonathan García-Roman, Ann-Katrin Sommer, Thomas Fröhlich, Georg J Arnold, Ernst Wagner, Andreas Roidl
Loss of miR-200c is correlated to advanced cancer-subtypes due to increased EMT and decreased treatment efficacy by chemotherapeutics. As miRNAs regulate a multitude of targets, the analysis of differentially expressed proteins upon a genomic knock-out (KO) is of interest. In this study, we generated a TALENs KO of miR-200c in MCF7 breast cancer cells, excluded its compensation by family-members and evaluated the impact on the proteome by analyzing three individual KO-clones. We identified 26 key proteins and a variety of enrichments in metabolic and cytoskeletal pathways...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29720407/diagnostic-potential-of-stored-dried-blood-spots-for-inborn-errors-of-metabolism-a-metabolic-autopsy-of-medium-chain-acyl-coa-dehydrogenase-deficiency
#13
Noriyuki Kaku, Kenji Ihara, Yuichiro Hirata, Kenji Yamada, Sooyoung Lee, Hikaru Kanemasa, Yoshitomo Motomura, Haruhisa Baba, Tamami Tanaka, Yasunari Sakai, Yoshihiko Maehara, Shouichi Ohga
AIM: It is estimated that 1-5% of sudden infant death syndrome (SIDS) cases might be caused by undiagnosed inborn errors of metabolism (IEMs); however, the postmortem identification of IEMs remains difficult. This study aimed to evaluate the usefulness of dried blood spots (DBSs) stored after newborn screening tests as a metabolic autopsy to determine the causes of death in infants and children who died suddenly and unexpectedly. METHODS: Infants or toddlers who had suddenly died without a definite diagnosis between July 2008 and December 2012 at Kyushu University Hospital in Japan were enrolled in this study...
May 2, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29719722/an-aggravated-return-to-work-case-of-organic-solvent-induced-chronic-toxic-encephalopathy
#14
Sangyun Seo, Jungwon Kim
Background: Organic solvent-induced chronic toxic encephalopathy (CTE) is known as a non-progressive disorder that does not progress after diagnosis. The authors present a case those symptoms worsened after continued exposure to organic solvent after returning to work. Because such a case has not been reported in South Korea to the best of our knowledge, we intend to report this case along with literature review. Case presentation: A 59-year-old man, who performed painting job at a large shipyard for 20 years, was receiving hospital treatment mainly for depression...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29718709/intrauterine-programming-mechanism-for-hypercholesterolemia-in-prenatal-caffeine-exposed-female-adult-rat-offspring
#15
Dan Xu, Hanwen W Luo, Wen Hu, Shuwei W Hu, Chao Yuan, Guihua H Wang, Li Zhang, Hong Yu, Jacques Magdalou, Liaobin B Chen, Hui Wang
Clinical and animal studies have indicated that hypercholesterolemia and its associated diseases have intrauterine developmental origins. Our previous studies showed that prenatal caffeine exposure (PCE) led to fetal overexposure to maternal glucocorticoids (GCs) and increased serum total cholesterol levels in adult rat offspring. This study further confirms the intrauterine programming of PCE-induced hypercholesterolemia in female adult rat offspring. Pregnant Wistar rats were intragastrically administered caffeine (30, 60, and 120 mg/kg/d) from gestational day (GD)9 to 20...
May 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29709336/short-term-metabolic-control-and-sleep-in-children-and-adolescents-with-type-1-diabetes-mellitus
#16
Martina Kostkova, Peter Durdik, Miriam Ciljakova, Jarmila Vojtkova, Anna Sujanska, Katarina Pozorciakova, Zuzana Snahnicanova, Maria Jancinova, Peter Banovcin
AIMS: The aim of this study was to examine sleep in T1D children and in healthy controls by polysomnographic (PSG) examination and to determine the influence of short-term metabolic compensation on sleep quality and sleep disordered breathing (SDB). METHODS: The prospective cross-sectional study included 44 T1D subjects and 60 healthy controls, aged 10-19 years. Subjects underwent anthropometric measurements, laboratory testing and standard overnight in-laboratory video polysomnography with continuous glucose monitoring (CGM)...
March 22, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29705134/increase-in-liver-cytosolic-lipases-activities-and-vldl-tag-secretion-rate-do-not-prevent-the-non-alcoholic-fatty-liver-disease-in-cafeteria-diet-fed-rats
#17
Anderson Fernandes de Melo, Carolina Campos Lima Moreira, Camila Ferreira Sales, Thiago Rentz, Helena Fonseca Raposo, Maria Antonieta Rissato Garófalo, Leida Maria Botion, Isis do Carmo Kettelhut, Helena Coutinho Franco de Oliveira, Valéria Ernestânia Chaves
We have previously shown that the cafeteria diet increases body fat mass, triacylglycerol (TAG) and insulin plasma levels, glucose uptake by white and brown adipose tissues, as well as the sympathetic activity to both adipose tissues in Wistar rats. The metabolic pathways responsible for the development of non-alcoholic fatty liver disease (NAFLD) were examined in cafeteria diet-fed rats. After 3 weeks offering cafeteria diet, we evaluated: (i) activity of the sympathetic nervous system by norepinephrine turnover rates; (ii) de novo fatty acid synthesis in vivo using 3H2O; (iii) secretion of very low density lipoprotein (VLDL)-TAG secretion measuring serum TAG levels after administration of lipase lipoprotein inhibitor, (iv) liver cytosolic lipases activity and (v) liver mRNA expression of enzymes involved in lipids secretion and oxidation by RT-PCR...
April 26, 2018: Biochimie
https://www.readbyqxmd.com/read/29703920/prevalent-metabolic-derangement-and-severe-thrombocytopenia-in-abo-incompatible-liver-recipients-with-pre-transplant-plasma-exchange
#18
Hye-Mee Kwon, In-Gu Jun, JungBok Lee, Young-Jin Moon, Kyeo-Woon Jung, Hye-Won Jeong, Yong-Seok Park, Jun-Gol Song, Gyu-Sam Hwang
Desensitisation with therapeutic plasma exchange (TPE) is essential for ABO-incompatible (ABO-I) liver transplants (LTs). However, excessive citrate load and coagulation disturbances after TPE have been poorly studied, in particular in cirrhotic patients with hypocapnic alkalosis, metabolic compensation and electrolyte imbalances. We retrospectively evaluated 1123 consecutive LT recipients (923 ABO-compatible [ABO-C], 200 ABO-I) from November 2008 to May 2015. TPE was generally performed a day before LT and blood sampling was performed before anaesthesia induction...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29703132/genomic-insights-into-natural-selection-in-the-common-loon-gavia-immer-evidence-for-aquatic-adaptation
#19
Zach G Gayk, Diana Le Duc, Jeffrey Horn, Alec R Lindsay
BACKGROUND: The common loon (Gavia immer) is one of five species that comprise the avian order Gaviiformes. Loons are specialized divers, reaching depths up to 60 m while staying submerged for intervals up to three minutes. In this study we used comparative genomics to investigate the genetic basis of the common loon adaptations to its ecological niche. We used Illumina short read DNA sequence data from a female bird to produce a draft assembly of the common loon (Gavia immer) genome...
April 27, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29692699/a-control-scheme-that-uses-dynamic-postural-synergies-to-coordinate-a-hybrid-walking-neuroprosthesis-theory-and-experiments
#20
Naji A Alibeji, Vahidreza Molazadeh, Brad E Dicianno, Nitin Sharma
A hybrid walking neuroprosthesis that combines functional electrical stimulation (FES) with a powered lower limb exoskeleton can be used to restore walking in persons with paraplegia. It provides therapeutic benefits of FES and torque reliability of the powered exoskeleton. Moreover, by harnessing metabolic power of muscles via FES, the hybrid combination has a potential to lower power consumption and reduce actuator size in the powered exoskeleton. Its control design, however, must overcome the challenges of actuator redundancy due to the combined use of FES and electric motor...
2018: Frontiers in Neuroscience
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