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https://www.readbyqxmd.com/read/28324785/-ub006-a-new-fatty-acid-synthase-inhibitor-and-cytotoxic-agent-without-anorexic-side-effects
#1
Kamil Makowski, Joan Francesc Mir, Paula Mera, Xavier Ariza, Guillermina Asins, Fausto G Hegardt, Laura Herrero, Jordi García, Dolors Serra
C75 is a synthetic anticancer drug that inhibits fatty acid synthase (FAS) and shows a potent anorexigenic side effect. In order to find new cytotoxic compounds that do not impact food intake, we synthesized a new family of C75 derivatives. The most promising anticancer compound among them was UB006 ((4SR,5SR)-4-(hydroxymethyl)-3-methylene-5-octyldihydrofuran-2(3H)-one). The effects of this compound on cytotoxicity, food intake and body weight were studied in UB006 racemic mixture and in both its enantiomers separately...
March 12, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28318643/cxcl10-alters-the-tumour-immune-microenvironment-and-disease-progression-in-a-syngeneic-murine-model-of-high-grade-serous-ovarian-cancer
#2
Katrina K Au, Nichole Peterson, Peter Truesdell, Gillian Reid-Schachter, Kasra Khalaj, Runhan Ren, Julie-Ann Francis, Charles H Graham, Andrew W Craig, Madhuri Koti
OBJECTIVE: We recently established that high STAT1 expression and associated T helper type I tumour immune microenvironment (TME) are prognostic and chemotherapy response predictive biomarkers in high-grade serous ovarian cancer (HGSC). STAT1 induced chemokine CXCL10 is key to the recruitment of lymphocytes in the TME and is significantly highly expressed in the tumours from patients with longer survival. In the current study we therefore aimed to elucidate the role CXCL10 in disease progression and tumour immune transcriptomic alterations using the ID8 syngeneic murine model of HGSC...
March 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28318555/regulation-of-the-prorenin-angiotensin-system-by-oxygen-and-mirnas-parallels-between-placentation-and-tumour-development
#3
Sarah J Delforce, Eugenie R Lumbers, Kirsty G Pringle
Tissue renin-angiotensin systems (RASs) are involved in tissue growth and development as they are important regulators of angiogenesis, cell proliferation and migration. The placental RAS is most highly expressed in early gestation, at a time when the oxygen tension within the conceptus is reduced, and plays a key role in placental growth and development. Similar to the placenta, tumour development relies on proliferation, angiogenesis and invasion in order to grow and metastasize. The RAS is known to be upregulated in a variety of solid tumours, including ovarian, endometrial, cervical, breast and prostate...
March 10, 2017: Placenta
https://www.readbyqxmd.com/read/28301874/veph1-expression-decreases-vascularisation-in-ovarian-cancer-xenografts-and-inhibits-vegfa-and-il8-expression-through-inhibition-of-akt-activation
#4
Premalatha Shathasivam, Alexandra Kollara, Thomasina Spybey, Soyeon Park, Blaise Clarke, Maurice J Ringuette, Theodore J Brown
BACKGROUND: VEPH1 is amplified in several cancers including ovarian but its impact on tumour progression is unknown. Previous work has shown that VEPH1 inhibits TGFβ signalling while its Drosophila ortholog increases tissue growth, raising the possibility that VEPH1 could impact tumour growth or progression. METHODS: A CRISPR approach was used to disrupt VEPH1 expression in ovarian cancer ES-2 cells, while VEPH1-negative SKOV3 cells were stably transfected with VEPH1 cDNA...
March 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28289945/a-novel-representation-of-inter-site-tumour-heterogeneity-from-pre-treatment-computed-tomography-textures-classifies-ovarian-cancers-by-clinical-outcome
#5
Hebert Alberto Vargas, Harini Veeraraghavan, Maura Micco, Stephanie Nougaret, Yulia Lakhman, Andreas A Meier, Ramon Sosa, Robert A Soslow, Douglas A Levine, Britta Weigelt, Carol Aghajanian, Hedvig Hricak, Joseph Deasy, Alexandra Snyder, Evis Sala
PURPOSE: To evaluate the associations between clinical outcomes and radiomics-derived inter-site spatial heterogeneity metrics across multiple metastatic lesions on CT in patients with high-grade serous ovarian cancer (HGSOC). METHODS: IRB-approved retrospective study of 38 HGSOC patients. All sites of suspected HGSOC involvement on preoperative CT were manually segmented. Gray-level correlation matrix-based textures were computed from each tumour site, and grouped into five clusters using a Gaussian Mixture Model...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28289938/primary-and-metastatic-ovarian-cancer-characterization-by-3-0t-diffusion-weighted-mri
#6
Auni Lindgren, Maarit Anttila, Suvi Rautiainen, Otso Arponen, Annukka Kivelä, Petri Mäkinen, Kirsi Härmä, Kirsi Hämäläinen, Veli-Matti Kosma, Seppo Ylä-Herttuala, Ritva Vanninen, Hanna Sallinen
OBJECTIVES: We aimed to investigate whether apparent diffusion coefficients (ADCs) measured by 3.0T diffusion-weighted magnetic resonance imaging (DWI) associate with histological aggressiveness of ovarian cancer (OC) or predict the clinical outcome. This prospective study enrolled 40 patients with primary OC, treated 2011-2014. METHODS: DWI was performed prior to surgery. Two observers used whole lesion single plane region of interest (WLsp-ROI) and five small ROIs (S-ROI) to analyze ADCs...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28284928/-18-f-fdg-pet-ct-as-predictor-of-tumour-biology-and-prognosis-in-epithelial-ovarian-carcinoma
#7
B González García, A M García Vicente, G A Jiménez Londoño, F J Pena Pardo, M E Bellón Guardia, M P Talavera Rubio, A Palomar Muñoz, P Gómez Herrero, Á M Soriano Castrejón
OBJECTIVE: To investigate the relationship between maximum standardised uptake value (SUVmax) of ovarian lesions and histopathology subtypes, and their involvement in the response and prognosis of patients with epithelial ovarian carcinoma (EOC). MATERIAL AND METHODS: A retrospective analysis of 31 patients with EOC and (18)F-FDG-PET/CT before treatment, including an assessment of the SUVmax of ovarian lesion. Histopathological diagnosis and follow-up was performed...
March 8, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28278370/exploring-the-influence-of-the-aromaticity-on-the-anti-cancer-and-anti-vascular-activities-of-organoplatinum-ii-complexes
#8
Ana Zamora, Sergio A Pérez, Matthias Rothemund, Venancio Rodríguez, Rainer Schobert, Christoph Janiak, José Ruiz
A series of new organometallic Pt(II) complexes of the type [Pt(C^N)Cl(DMSO)] (C^N = N,N-dimethyl-1-(2-aryl)methanamine-K2C2,N; aryl = phenyl 2a, biphenyl 2b, p-terphenyl 2c, naphthyl 2d, anthracenyl 2e, pyrenyl 2f) have been synthesized to explore the influence of the aromaticity on their anticancer activity. The best performers 2b and 2d are more active than CDDP in epithelial ovarian carcinoma cells A2780, with 2d having a higher selectivity factor than CDDP in all the tested cell lines. In addition, all the new compounds overcome the acquired resistance in A2780cisR cells and interestingly, show low micromolar IC50 values towards the triple negative breast tumour cell line MDA-MB-231 and the highly metastatic 518A2 melanoma cells...
March 9, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28277616/-e-2-methoxy-4-3-4-methoxyphenyl-prop-1-en-1-yl-phenol-suppresses-ovarian-cancer-cell-growth-via-inhibition-of-erk-and-stat3
#9
Jie Zheng, Dong Ju Son, Hye Lim Lee, Hee Pom Lee, Tae Hoon Kim, Jung Heun Joo, Young Wan Ham, Wun Jae Kim, Jae Kyung Jung, Sang-Bae Han, Jin Tae Hong
In the present study, we synthesized several non-aldehyde analogues of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal which showed anti-cancer effect. Interestingly, among the 16 compounds, we found that (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol (MMPP) showed the most significant anti-proliferative effect on PA-1 and SK-OV-3 ovarian epithelial cancer cells. MMPP treatment (0-15 µg/mL) induced apoptotic cell death, enhanced the expression of cleaved caspase-3 and cleaved caspase-9 in a concentration dependent manner...
March 9, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28275392/clinical-response-in-patients-with-ovarian-cancer-treated-with-metronomic-chemotherapy
#10
Herman Andrés Perroud, O Graciela Scharovsky, Viviana Rosa Rozados, Carlos María Alasino
Ovarian cancer (OC) is the leading cause of death from gynaecological cancer. It is extremely hard to diagnose in the early stages and around 70% of patients present with advanced disease. Metronomic chemotherapy (MCT) is described as the chronic administration of, generally low, equally spaced, doses of chemotherapeutic drugs with therapeutic efficacy and low toxicity. This is an effective and low-cost way to treat several types of tumours, including ovarian cancer. Here, we present six cases of advanced ovarian cancer treated with MCT with low doses of cyclophosphamide, which showed clinical response and stable disease...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28274004/triple-synchronous-malignancies-in-genital-tract-primary-endometrial-ovarian-and-fallopian-tube-carcinoma-a-case-report
#11
Ozgur Kan, Aysegul Alkilic, Batuhan Turgay, Ali Gemici, Cem Somer Atabekoglu
Synchronous malignancies, including three or more tumours, are extremely rare. Herein, we present a case of a woman with a concurrent simultaneous endometrial, ovarian and fallopian tubal carcinoma with different histopathological characteristics. A 55-year-old postmenopausal woman with a diagnosis of endometrial adenocarcinoma by pipelle biopsy, underwent surgical staging. Final pathology result was reported as synchronous stage IA grade 2 endometrioid adenocarcinoma of the uterus, stage IA grade 2 mucinous adenocarcinoma of the right ovary and in situ serous cystadenocarcinoma of the right fallopian tube...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273485/clinical-factors-of-response-in-patients-with-advanced-ovarian-cancer-participating-in-early-phase-clinical-trials
#12
Angela George, Rebecca Kristeleit, Saeed Rafii, Caroline O Michie, Rebecca Bowen, Vasiliki Michalarea, Tom van Hagen, Mabel Wong, Grigorios Rallis, L Rhoda Molife, Juanita Lopez, Udai Banerji, Susana N Banerjee, Martin E Gore, Johann S de Bono, Stan B Kaye, Timothy A Yap
Drug resistance to conventional anticancer therapies is almost inevitable in patients with advanced ovarian cancer (AOC), limiting their available treatment options. Novel phase I trial therapies within a dedicated drug development unit may represent a viable alternative; however, there is currently little evidence for patient outcomes in such patients. To address this, we undertook a retrospective review of patients with AOC allocated to phase I trials in the Drug Development Unit at Royal Marsden Hospital (RMH) between June 1998 and October 2010...
March 5, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28262727/malignant-extracellular-vesicles-carrying-mmp1-mrna-facilitate-peritoneal-dissemination-in-ovarian-cancer
#13
Akira Yokoi, Yusuke Yoshioka, Yusuke Yamamoto, Mitsuya Ishikawa, Shun-Ichi Ikeda, Tomoyasu Kato, Tohru Kiyono, Fumitaka Takeshita, Hiroaki Kajiyama, Fumitaka Kikkawa, Takahiro Ochiya
Advanced ovarian cancers are highly metastatic due to frequent peritoneal dissemination, resulting in dismal prognosis. Here we report the functions of cancer-derived extracellular vesicles (EVs), which are emerging as important mediators of tumour metastasis. The EVs from highly metastatic cells strongly induce metastatic behaviour in moderately metastatic tumours. Notably, the cancer EVs efficiently induce apoptotic cell death in human mesothelial cells in vitro and in vivo, thus resulting in the destruction of the peritoneal mesothelium barrier...
March 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28255981/bilateral-primary-pigmented-nodular-adrenal-disease-as-a-component-of-carney-syndrome-case-report
#14
Dorota Sikorska, Lucyna Bednarek-Papierska, Ewa Mojs, Ewa Makowska, Marek Ruchała, Włodzimierz Samborski
We report a case of a 20-year-old patient with Cushing's syndrome as a component of Carney syndrome. Carney syndrome is an autosomal dominant disease with co-existing bilateral pigmented nodular adrenal disease, heart and skin myxoma, skin pigmentation, breast fibroadenoma, testicular and ovarian tumours, thyroid tumours, and pituitary adenomas. (Endokrynol Pol 2017; 68 (1): 70-72).
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28250728/case-report-of-ovarian-torsion-mimicking-ovarian-cancer-as-an-uncommon-late-complication-of-laparoscopic-supracervical-hysterectomy
#15
Michał Ciebiera, Arkadiusz Baran, Aneta Słabuszewska-Jóźwiak, Grzegorz Jakiel
Laparoscopic supracervical hysterectomy (LSH) is an example of a partial hysterectomy, performed due to benign gynaecological complaints. Better endoscopic instruments and operational techniques have led to a great reduction in the number of abdominal hysterectomies. It is believed that LSH is a safe and minimally invasive hysterectomy technique. The Cochrane Database meta-analysis proves the benefits of minimally invasive surgery compared with abdominal gynaecological surgery, including decreased pain, surgical-site infections and hospital stay, quicker return to activity, and fewer postoperative adhesions...
December 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28250724/the-influence-of-uterine-artery-embolisation-on-ovarian-reserve-fertility-and-pregnancy-outcomes-a-review-of-literature
#16
REVIEW
Piotr Czuczwar, Anna Stępniak, Wojciech Wrona, Sławomir Woźniak, Paweł Milart, Tomasz Paszkowski
Uterine fibroids are considered to be the most frequent female benign tumours. Fibroids affect mainly women of reproductive age. The most frequently reported signs and symptoms of fibroids include disturbances of the menstrual cycle such as heavy bleeding and painful menstruation, pelvic masses associated with pelvic pain, urinary problems or constipation, as well as infertility and recurrent pregnancy loss. The mainstay of fibroid treatment is still surgery. However, many patients seek alternative treatment options for fibroids, to preserve their uterus and fertility...
December 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28247413/mesothelial-to-mesenchymal-transition-as-a-possible-therapeutic-target-in-peritoneal-metastasis-of-ovarian-cancer
#17
Angela Rynne-Vidal, Chi Lam Au-Yeung, José A Jiménez-Heffernan, María Luisa Pérez-Lozano, Lucía Cremades-Jimeno, Carmen Bárcena, Ignacio Cristóbal-García, Concepción Fernández-Chacón, Tsz Lun Yeung, Samuel C Mok, Pilar Sandoval, Manuel López-Cabrera
Peritoneal dissemination is the primary metastatic route of ovarian cancer (OvCa), often accompanied by accumulation of ascitic fluid. The peritoneal cavity is lined by mesothelial cells (MCs), which can convert into carcinoma-associated fibroblasts (CAFs) through mesothelial-to-mesenchymal transition (MMT). Here, we demonstrate that MCs isolated from ascitic fluid (AFMCs) of OvCa patients with peritoneal implants also undergo MMT and promote subcutaneous tumour growth in mice. RNA sequencing of AFMCs revealed that MMT-related pathways-including TGF-β signalling-are differentially regulated, and a gene signature was verified in peritoneal implants from OvCa patients...
March 1, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28247266/rucaparib-first-global-approval
#18
Yahiya Y Syed
Rucaparib (Rubraca™) is an oral, small molecule, poly (ADP-ribose) polymerase inhibitor being developed by Clovis Oncology, Inc. (Boulder, CO, USA) for the treatment of solid tumours. It has been approved in the USA as monotherapy for the treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies. A marketing authorization application for rucaparib for the same indication has been submitted to the European Medicines Agency...
March 1, 2017: Drugs
https://www.readbyqxmd.com/read/28242502/the-role-of-bevacizumab-in-solid-tumours-a-literature-based-meta-analysis-of-randomised-trials
#19
REVIEW
Giandomenico Roviello, Thomas Bachelot, Clifford A Hudis, Giuseppe Curigliano, Andrew R Reynolds, Roberto Petrioli, Daniele Generali
BACKGROUND: Bevacizumab is a humanised monoclonal antibody which blocks the binding of circulating vascular endothelial growth factor to its receptors. To date, the Food and Drug Administration has approved bevacizumab for the treatment of several solid tumours. To assess the impact of bevacizumab-based regimens on outcome in these advanced solid tumour types, we performed a meta-analysis. We included all of the randomised trials (phase II or III) where bevacizumab was tested in the first line setting compared with a control arm, including chemotherapy, placebo or other anti-neoplastic agents...
February 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28240757/-anti-m%C3%A3-llerian-hormone-a-brief-review-of-the-literature
#20
G Ozzola
BACKGROUND: Anti-Müllerian hormone (AMH) is a dimeric glycoprotein, which was originally identified because of its role in male sexual differentiation. In fact, AMH is expressed by the Sertoli cellsof the foetal testes and induces the regression of the Müllerian ducts. In the absence of AMH, the Müllerian ducts evolve in the uterus, fallopian tubes and in the upper part of the vagina. In women AMH is produced by granulose cells, pre-antral and antral follicles and its major physiological role in the ovaries seems to be limited to inhibiting the development of the earliest stages of follicular development...
January 2017: La Clinica Terapeutica
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