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Góra Bartłomiej, Gofron Zygmunt, Grosiak Magdalena, Aptekorz Małgorzata, Kazek Beata, Kocelak Piotr, Radosz-Komoniewska Halina, Chudek Jerzy, Martirosian Gayane
Infectious factors are taken into consideration in pathophysiology of autism spectrum disorders (ASD). ASD patients often suffer from gastrointestinal disorders. The intestinal microbiota of autistic patients significantly differs from that in healthy individuals. The aim of the study was to compare the profile of toxins produced by C. perfringens strains isolated from feces of children with ASD, with healthy individuals and obese subjects. This study included 111 strains of C. perfringens: 49 isolates from 29 children with ASD, 30 - from 17 healthy individuals and 32 - from 24 young obese subjects...
March 8, 2018: Anaerobe
F Moro, G Magoga, T Pasciuto, F Mascilini, M C Moruzzi, D Fischerova, L Savelli, S Giunchi, R Mancari, D Franchi, A Czekierdowski, W Froyman, D Verri, E Epstein, V Chiappa, S Guerriero, G F Zannoni, D Timmerman, G Scambia, L Valentin, A C Testa
OBJECTIVE: To describe the clinical and ultrasound characteristics of ovarian pure endometrioid carcinoma. METHODS: This is a retrospective multicenter study. From the International Ovarian Tumor Analysis (IOTA) database we identified 161 patients with a histological diagnosis of pure endometrioid carcinoma, who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 1999 and 2016. Another 78 patients with a histological diagnosis of pure endometrioid carcinoma were identified from the databases of the departments of gynecological oncology in the participating centers...
February 8, 2018: Ultrasound in Obstetrics & Gynecology
Athira Cheruplackal Karunakarnan, Arockiasamy Arun Prince Milton, Avinash Reddy, Arunraj Mekhemadhom Rajendrakumar, Abhishek, Med Ram Verma, Ashok Kumar, Viswas Konasagara Nagaleekar, Rajesh Kumar Agarwal
The diversity of toxin-genotypes of C. perfringens in neonatal calves was determined in this study. A total of 682 fresh faecal samples comprising 559 healthy and 123 diarrheic neonatal calves (cattle and buffalo) were collected from various farms in Northern India. The samples were processed for isolation of C. perfringens and toxin-genotyping by multiplex PCR. The overall prevalence of C. perfringens was 37.2%. The most predominant toxin-genotype was type A (59.7%) and the least prevalent was type C. There was no association between toxin genotypes and diarrhea of cattle and buffalo neonatal calves (P > ...
January 4, 2018: Anaerobe
O Diallo, L Traoré, F Traoré, A Simaga, J P Thera, B Coulibaly, M Diarra, M Sidibé, J Traoré, F N'Diaye
The aim of this work was to evaluate the public transport drivers' visual driving ability in Bamako. We carried out a descriptive cross-sectional study from May 15 to July 15, 2013. The probabilistic method was used. 385 drivers were examined at the University Hospital of the Institute of Tropical Ophthalmology of Africa (IOTA). The average age was 44.69 years. 296 drivers (76.9%) were able to drive public transport vehicles. Among drivers over 50 years old, 42.5% are unfit for driving. Color vision was normal in 98...
December 2017: Bulletin de la Société de Pathologie Exotique
Nicole Brimer, Camille M Drews, Scott B Vande Pol
Papillomavirus E6 proteins bind to LXXLL peptide motifs displayed on targeted cellular proteins. Alpha genus HPV E6 proteins associate with the cellular ubiquitin ligase E6AP (UBE3A), by binding to an LXXLL peptide (ELTLQELLGEE) displayed by E6AP, thereby stimulating E6AP ubiquitin ligase activity. Beta, Gamma, and Delta genera E6 proteins bind a similar LXXLL peptide (WMSDLDDLLGS) on the cellular transcriptional co-activator MAML1 and thereby repress Notch signaling. We expressed 45 different animal and human E6 proteins from diverse papillomavirus genera to ascertain the overall preference of E6 proteins for E6AP or MAML1...
December 27, 2017: PLoS Pathogens
Kanane Shimada, Koji Matsumoto, Takashi Mimura, Tetsuya Ishikawa, Jiro Munechika, Yoshimitsu Ohgiya, Miki Kushima, Yusuke Hirose, Yuka Asami, Chiaki Iitsuka, Shingo Miyamoto, Mamiko Onuki, Hajime Tsunoda, Ryu Matsuoka, Kiyotake Ichizuka, Akihiko Sekizawa
BACKGROUND: The diagnostic performances of the International Ovarian Tumor Analysis (IOTA) ultrasound-based logistic regression model (LR2) and magnetic resonance imaging (MRI) in discriminating between benign and malignant adnexal masses have not been directly compared in a single study. METHODS: Using the IOTA LR2 model and subjective interpretation of MRI findings by experienced radiologists, 265 consecutive patients with adnexal masses were preoperatively evaluated in two hospitals between February 2014 and December 2015...
December 13, 2017: International Journal of Clinical Oncology
Theera Tongsong, Chanane Wanapirak, Charuwan Tantipalakorn, Dangcheewan Tinnangwattana
Objective: To evaluate diagnostic performance of IOTA simple rules plus pattern recognition in predicting tubal cancer. Methods: Secondary analysis was performed on prospective database of our IOTA project. The patients recruited in the project were those who were scheduled for pelvic surgery due to adnexal masses. The patients underwent ultrasound examinations within 24 hours before surgery. On ultrasound examination, the masses were evaluated using the well-established IOTA simple rules plus pattern recognition (sausage-shaped appearance, incomplete septum, visible ipsilateral ovaries) to predict tubal cancer...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Erin P McCauley, Hanh Lam, Nicholas Lorig-Roach, Justin Luu, Cameron Lloyd, Karen Tenney, Halina Pietraszkiewicz, Cristina Diaz, Frederick A Valeriote, Victoria Auerbuch, Phillip Crews
This research set out to identify compounds from marine sponges that can act as bacterial virulence blockers. Extracts from a total of 80 sponges collected from throughout Indonesia were screened in a high-throughput NF-κB-based screen that identifies compounds capable of inhibiting the bacterial type III secretion system (T3SS) in Yersinia pseudotuberculosis. An extract that was shown to inhibit T3SS-driven NF-κB expression was obtained from an Iotrochota cf. iota sponge and was the source of seven new bromo- and iodo-containing compounds, all of which contain a 2-(4-oxyphenyl)ethan-1-amine core...
November 16, 2017: Journal of Natural Products
Chiara Landolfo, Lil Valentin, Dorella Franchi, Caroline Van Holsbeke, Robert Fruscio, Wouter Froyman, Povilas Sladkevicius, Jeroen Kaijser, Lieveke Ameye, Tom Bourne, Luca Savelli, An Coosemans, Antonia Testa, Dirk Timmerman
OBJECTIVES: The aim is to determine if there are any ultrasound features of papillations or of the cyst wall that can discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. METHODS: Patients with an adnexal lesion described at ultrasonography as unilocular-solid with papillations but no other solid components were identified from the International Ovarian Tumor Analysis (IOTA) database derived from seven ultrasound centers...
November 8, 2017: Ultrasound in Obstetrics & Gynecology
Ahmed Ghannam, Hossam Murad, Marie Jazzara, Adnan Odeh, Abdul Wahab Allaf
Hydrocolloids from seaweeds (phycocolloids) have interesting functional properties like antiproliferative activity. Marine algae consumptions are linked to law cancer incidences in countries that traditionally consume marine products. In this study, we have investigated water-soluble sulfated polysaccharides isolated from the red seaweed Laurencia papillosa and determined their chemical characteristics and biological activities on the human breast cancer cell line MCF-7. Total polysaccharides were extracted and fractionated from L...
November 4, 2017: International Journal of Biological Macromolecules
María D Torres, Francisco Chenlo, Ramón Moreira
water adsorption and desorption isotherms of kappa/iota-hybrid carrageenan (KIC) extracted from Mastocarpus stellatus red seaweed as well as commercial kappa-carrageenan (KC) and iota-carrageenan (IC) were obtained at several temperatures (5, 25, 45, 65°C). Spectroscopic and X-ray diffraction techniques allowed identifying the fundamental composition of above biopolymers. Crystallinity values (%) followed the order IC (25.4±0.6)> KIC (9.3±0.4)> KC (4.8±0.2), which nicely matched with the hygroscopic properties of the tested biopolymers (KC > KIC > IC) at each temperature...
January 15, 2018: Carbohydrate Polymers
Bilian Ke, Xinjie Mao, Hong Jiang, Jichang He, Che Liu, Min Li, Ying Yuan, Jianhua Wang
Purpose: This study investigated the anterior ocular anatomic origin of high-order aberration (HOA) components using optical coherence tomography and a Shack-Hartmann wavefront sensor. Methods: A customized system was built to simultaneously capture images of ocular wavefront aberrations and anterior ocular biometry. Relaxed, 2-diopter (D) and 4-D accommodative states were repeatedly measured in 30 young subjects. Custom software was used to correct optical distortions and measure biometric parameters from the images...
November 1, 2017: Investigative Ophthalmology & Visual Science
Shridhar C Ghagane, Sridevi I Puranik, Siew Hua Gan, Murigendra B Hiremath, R B Nerli, M V Ravishankar
With the flourishing of innovation in drug discovery into a new era of personalized therapy, the use of monoclonal antibodies (mAbs) in the treatment of various ailments lies at the forefront. Major improvements in genetic sequencing and biomedical techniques as well as research into mAbs emphasize on determining new targets for advanced therapy while maximizing efficacy for clinical application. However, a balance has to be achieved concerning developing a target with low toxicity combined with high specificity and versatility, to allow a specific antibody to facilitate several biotic effects, ranging from neutralization of virus mechanisms to modulation of immune response and maintaining low global economic cost...
October 13, 2017: Human Antibodies
Wishrawana S Ratnayake, André H Apostolatos, David A Ostrov, Mildred Acevedo-Duncan
Atypical protein kinase Cs (aPKC) are involved in cell cycle progression, tumorigenesis, cell survival and migration in many cancers. We believe that aPKCs play an important role in cell motility of melanoma by regulating cell signaling pathways and inducing epithelial to mesenchymal transition (EMT). We have investigated the effects of two novel aPKC inhibitors; 2-acetyl-1,3-cyclopentanedione (ACPD) and 3,4-diaminonaphthalene-2,7-disulfonic acid (DNDA) on cell proliferation, apoptosis, migration and invasion of two malignant melanoma cell lines compared to normal melanocytes...
September 22, 2017: International Journal of Oncology
Mahnaz Ramezanpour, Jae Murphy, Jason L P Smith, Sarah Vreugde, Alkis James Psaltis
BACKGROUND: Carrageenans have shown to reduce the viral load in nasal secretions and lower the incidence of secondary infections in children with common cold. Despite the widespread use of carrageenans in topical applications, the effect of carrageenans on the sinonasal epithelial barrier has not been elucidated. We investigate the effect of different carrageenans on the sinonasal epithelial barrier and inflammatory response in vitro. METHODS: Iota and Kappa carrageenan delivered in saline irrigation solutions applied to air-liquid interface (ALI) cultures of primary human nasal epithelial cells from chronic rhinosinusitis patients and controls...
December 2017: International Forum of Allergy & Rhinology
Natalie Nunes, Gareth Ambler, Xulin Foo, Martin Widschwendter, Davor Jurkovic
OBJECTIVES: To determine whether IOTA diagnostic models developed for pre-operative diagnosis of ovarian cancer could also be used to differentiate between benign and malignant adnexal tumours in the population of women attending gynaecology outpatient clinics. METHODS: All women referred to our outpatient clinic were first examined by a Level II ultrasound operator. In those diagnosed with adnexal tumours the IOTA LR1/2 protocol was used to evaluate the masses...
October 4, 2017: Ultrasound in Obstetrics & Gynecology
Sugandha Garg, Amarjit Kaur, Jaswinder Kaur Mohi, Preet Kanwal Sibia, Navkiran Kaur
INTRODUCTION: IOTA stands for International Ovarian Tumour Analysis group. Ovarian cancer is one of the common cancers in women and is diagnosed at later stage in majority. The limiting factor for early diagnosis is lack of standardized terms and procedures in gynaecological sonography. Introduction of IOTA rules has provided some consistency in defining morphological features of ovarian masses through a standardized examination technique. AIM: To evaluate the efficacy of IOTA simple ultrasound rules in distinguishing benign and malignant ovarian tumours and establishing their use as a tool in early diagnosis of ovarian malignancy...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
T J Dobbins, K Ida, C Suzuki, M Yoshinuma, T Kobayashi, Y Suzuki, M Yoshida
A new Motional Stark Effect (MSE) analysis routine has been developed for improved spatial resolution in the core of the Large Helical Device (LHD). The routine was developed to reduce the dependency of the analysis on the Pfirsch-Schlüter (PS) current in the core. The technique used the change in the polarization angle as a function of flux in order to find the value of diota/dflux at each measurement location. By integrating inwards from the edge, the iota profile can be recovered from this method. This reduces the results' dependency on the PS current because the effect of the PS current on the MSE measurement is almost constant as a function of flux in the core; therefore, the uncertainty in the PS current has a minimal effect on the calculation of the iota profile...
September 2017: Review of Scientific Instruments
Chao He, Shuhua Wu, Aidi Gao, Ye Su, Han Min, Zeng-Fu Shang, Jinchang Wu, Li Yang, Wei-Qun Ding, Jundong Zhou
An aberrantly elevated expression of DNA polymerase ι (Pol ι) is significantly associated with poor prognosis of patients with esophageal squamous cell carcinoma (ESCC), yet the mechanisms behind this phenomenon remain obscure. Based on the RNA-Seq transcriptome and real-time PCR analysis, we identified ETS-1 as a candidate gene involved in Pol ι-mediated progression of ESCC. Wound-healing and transwell assay indicated that downregulation of ETS-1 attenuates Pol ι-mediated invasiveness of ESCC. Signaling pathway analysis showed that Pol ι enhances ETS-1 phosphorylation at threonine-38 through the Erk signaling pathway in ESCC cells...
December 2017: Cancer Science
Marion Flum, Michael Kleemann, Helga Schneider, Benjamin Weis, Simon Fischer, René Handrick, Kerstin Otte
Apoptosis is a genetically directed process of programmed cell death. A variety of microRNAs (miRNAs), endogenous single-stranded non-coding RNAs of about 22 nucleotides in length have been shown to be involved in the regulation of the intrinsic or extrinsic apoptotic pathways. There is increasing evidence that the aberrant expression of miRNAs plays a causal role in the development of diseases such as cancer. This makes miRNAs promising candidate molecules as therapeutic targets or agents. MicroRNA (miR)-217-5p has been implicated in carcinogenesis of various cancer entities, including colorectal cancer...
September 14, 2017: Journal of Cell Communication and Signaling
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