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https://www.readbyqxmd.com/read/28447539/feasibility-of-preference-driven-radiotherapy-dose-treatment-planning-to-support-shared-decision-making-in-anal-cancer
#1
Heidi S Rønde, Leonard Wee, John Pløen, Ane L Appelt
PURPOSE/OBJECTIVE: Chemo-radiotherapy is an established primary curative treatment for anal cancer, but clinically equal rationale for different target doses exists. If joint preferences (physician and patient) are used to determine acceptable tradeoffs in radiotherapy treatment planning, multiple dose plans must be simultaneously explored. We quantified the degree to which different toxicity priorities might be incorporated into treatment plan selection, to elucidate the feasible decision space for shared decision making in anal cancer radiotherapy...
April 27, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28445991/human-epidermal-growth-factor-receptor-2-expression-is-more-important-than-bacillus-calmette-guerin-treatment-in-predicting-the-outcome-of-t1g3-bladder-cancer
#2
Luigi Cormio, Francesca Sanguedolce, Antonella Cormio, Paolo Massenio, Maria Carmela Pedicillo, Simona Cagiano, Giuseppe Calò, Vincenzo Pagliarulo, Giuseppe Carrieri, Pantaleo Bufo
In the present study we tested the role of Human Epidermal Growth Factor Receptor-2 (HER-2) expression, as assayed by immunohistochemistry, in predicting recurrence and progression in 67 patients with T1G3 BC having undergone transurethral resection of bladder tumor (TURBT) alone (33) or TURBT + Bacillus Calmette Guerin (BCG) instillations (34). All patients had a negative restaging TURBT within 4 months after the first TURBT. At median follow-up of 75.7 months, the overall disease-free and progression-free rates were 35...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445934/jarid2-is-essential-for-the-maintenance-of-tumor-initiating-cells-in-bladder-cancer
#3
Xin-Xing Zhu, Ya-Wei Yan, Chun-Zhi Ai, Shan Jiang, Shan-Shan Xu, Min Niu, Xiang-Zhen Wang, Gen-Shen Zhong, Xi-Feng Lu, Yu Xue, Shaoqi Tian, Guangyao Li, Shaojun Tang, Yi-Zhou Jiang
Bladder cancer is the most common urologic malignancy in China, with an increase of the incidence and mortality rates over past decades. Recent studies suggest that bladder tumors are maintained by a rare fraction of cells with stem cell proprieties. Targeting these bladder tumor initiating cell (TICs) population can overcome the drug-resistance of bladder cancer. However, the molecular and genetic mechanisms regulating TICs in bladder cancer remain poorly defined. Jarid2 is implicated in signaling pathways regulating cancer cell epithelial-mesenchymal transition, and stem cell maintenance...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445278/analysis-of-treatment-of-large-abdominal-malignancies-in-children-complicated-with-abdominal-compartment-syndrome-report-of-six-cases
#4
Zeng Le-Xiang, Wu Yao-Hao, Li Na, Qiu Rong-Lin, Zhou Jia-Jia, Jiang Wen-Li, Zhang Jie, Deng Xiao-Geng
To explore effective treatment of large abdominal malignancies in children complicated with abdominal compartment syndrome (ACS).Six children with large abdominal malignancies complicated with ACS were admitted to our department from January 2013 to January 2016, and the changes in their breathing, heart rate, oxygen saturation, abdominal circumference, bladder pressure, and urine output, as well as the treatment measures and outcomes, were retrospectively analyzed.The 6 children included 1 child with bilateral nephroblastoma, 1 child with abdominal alveolar rhabdomyosarcoma, 1 child with right ovarian malignant teratoma complicated with abdominal glioma, 1 child with abdominal malignant teratoma, 1 child with right nephroblastoma, and 1 child with left adrenal gland neuroblastoma...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445126/clinical-features-and-surgical-treatment-of-sacral-schwannomas
#5
Weibo Pan, Zhan Wang, Nong Lin, Xin Huang, Meng Liu, Xiaobo Yan, Zhaoming Ye
BACKGROUND: Sacral schwannoma is relatively rare and both the early diagnosis and appropriate treatment of sacral schwannomas are equally very challenging. METHODS: 11 sacral schwannoma cases operated at the Second Affiliated Hospital, School of Medicine, Zhejiang University, from 2012 to 2016, were investigated retrospectively and 10 were followed up. All patients were assessed with X-ray, CT and MRI, and underwent an intralesional excision. RESULTS: One patient was male, nine were female and the average age was 48 (ranging between 31 and 63)...
April 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443589/significance-of-inverted-pattern-in-non-invasive-low-grade-papillary-urothelial-carcinoma-of-bladder
#6
Sehbal Arslankoz, İbrahim Kulaç, Dilek Ertoy Baydar
AIMS: The purpose of this study is to evaluate the impact of histological inverted pattern on recurrence in patients with newly diagnosed non-invasive low-grade papillary urothelial carcinoma of the urinary bladder. METHODS: A total of 81 patients with primary bladder non-invasive low-grade papillary urothelial carcinomadiagnosed in a single tertiary care center between 2000 and 2011 who had at least 1 year follow-up after an initial resection were included. All slides from each case were reviewed to determine the growth pattern (exophytic versus endophytic, i...
April 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443245/overexpression-of-the-atpase-inhibitory-factor-1-favors-a-non-metastatic-phenotype-in-breast-cancer
#7
Lucía García-Ledo, Cristina Nuevo-Tapioles, Carmen Cuevas-Martín, Inmaculada Martínez-Reyes, Beatriz Soldevilla, Lucía González-Llorente, José M Cuezva
Partial suppression of mitochondrial oxidative phosphorylation and the concurrent activation of aerobic glycolysis is a hallmark of proliferating cancer cells. Overexpression of the ATPase inhibitory factor 1 (IF1), an in vivo inhibitor of the mitochondrial ATP synthase, is observed in most prevalent human carcinomas favoring metabolic rewiring to an enhanced glycolysis and cancer progression. Consistently, a high expression of IF1 in hepatocarcinomas and in carcinomas of the lung, bladder, and stomach and in gliomas is a biomarker of bad patient prognosis...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28440444/mirna-556-3p-promotes-human-bladder-cancer-proliferation-migration-and-invasion-by-negatively-regulating-dab2ip-expression
#8
Chen Feng, Ping Sun, Jing Hu, Hua Feng, Mingqiu Li, Guibo Liu, Yanming Pan, Ying Feng, Yongliang Xu, Kejian Feng, Yukuan Feng
MicroRNAs (miRNAs) play critical roles in tumorigenesis and metastasis by negatively regulating gene expression through complementary binding to the 3'-untranslated region of target mRNAs. The role of miRNAs in expression of the tumor suppressor DAB2IP in bladder cancer (BC) remains unknown. The aim of the present study was to identify miRNAs targeting DAB2IP and determine their expression and function in BC. We predicted candidate miRNAs targeting DAB2IP using TargetScan software. Dual-luciferase reporter assays confirmed that miRNA-556-3p directly regulated DAB2IP expression...
April 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28438874/partial-cystectomy-for-atypical-isolated-recurrence-of-ovarian-adenocarcinoma-a-case-report-and-literature-review
#9
Nicolae Bacalbasa, Irina Balescu
BACKGROUND: Most cases with advanced-stage epithelial ovarian malignancies will experience recurrent disease at a certain moment of their evolution, even if maximal cytoreductive surgery has been performed at the moment of initial diagnosis. However, it seems that the best therapeutic strategy, in case of relapse, remains aggressive re-resection, with complete cytoreduction being the most efficient way to improve survival. MATERIALS AND METHODS: We present the case of a 55-year-old patient diagnosed with an isolated pelvic recurrence after stage IIIC surgically-treated ovarian cancer three years after primary cytoreduction...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28438624/bladder-recurrence-of-clear-cell-sarcoma-of-the-kidney-7-years-after-initial-presentation
#10
John Weaver, Tammy Ho, Adam Lang, Joel F Koenig, Douglas E Coplen, Louis Dehner, Erica J Traxel
Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal malignancy after Wilms tumor. CCSK has the potential to metastasize to distant sites and was historically known as the bone metastasizing renal tumor. We report an exceedingly rare case of a bladder recurrence of CCSK. Our patient presented with gross hematuria 7 years after initial complete response. He was found to have a large sessile bladder tumor and underwent a partial cystectomy with right pelvic lymph node dissection. Final pathology was metastatic CCSK...
April 21, 2017: Urology
https://www.readbyqxmd.com/read/28438520/urinary-long-noncoding-rnas-in-nonmuscle-invasive-bladder-cancer-new-architects-in-cancer-prognostic-biomarkers
#11
REVIEW
Daniela Terracciano, Matteo Ferro, Sara Terreri, Giuseppe Lucarelli, Carolina D'Elia, Gennaro Musi, Ottavio de Cobelli, Vincenzo Mirone, Amelia Cimmino
Several reports over the last 10 years provided evidence that long noncoding RNAs (lncRNAs) are often altered in bladder cancers. lncRNAs are longer than 200 nucleotides and function as important regulators of gene expression, interacting with the major pathways of cell growth, proliferation, differentiation, and survival. A large number of lncRNAs has oncogenic function and is more expressed in tumor compared with normal tissues. Their overexpression may be associated with tumor formation, progression, and metastasis in a variety of tumors including bladder cancer...
April 7, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28438487/processdriver-a-computational-pipeline-to-identify-copy-number-drivers-and-associated-disrupted-biological-processes-in-cancer
#12
Brittany Baur, Serdar Bozdag
Copy number amplifications and deletions that are recurrent in cancer samples harbor genes that confer a fitness advantage to cancer tumor proliferation and survival. One important challenge in computational biology is to separate the causal (i.e., driver) genes from passenger genes in large, aberrated regions. We propose a computational pipeline, called ProcessDriver, that prioritizes candidate drivers by relating cis genes within the copy number aberration to dysregulated trans genes and biological processes...
April 21, 2017: Genomics
https://www.readbyqxmd.com/read/28438212/primary-follicular-dendritic-cell-sarcoma-of-the-urinary-bladder-the-first-case-report-and-potential-diagnostic-pitfalls
#13
Guang-Jie Duan, You-Li Wu, Hui Sun, Lang Lang, Zhi-Wen Chen, Xiao-Chu Yan
BACKGROUND: Extranodal follicular dendritic cell sarcoma (FDCS) is a very rare malignancy with a variable clinical course. It is often not considered and has the potential to result in a misdiagnosis of other common sarcomas or sarcomatoid carcinomas. This is particularly true with the preoperative biopsy specimen, in which the tissue sample is often small. CASE PRESENTATION: A case of FDCS in a 63-year-old woman, arising in the urinary bladder, a previously unreported site, is described...
April 24, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28437329/metastatic-spinal-cord-compression-and-steroid-treatment-a-systematic-review
#14
Abhishek Kumar, Michael H Weber, Ziya Gokaslan, Jean-Paul Wolinsky, Meic Schmidt, Laurence Rhines, Michael G Fehlings, Ilya Laufer, Daniel M Sciubba, Michelle J Clarke, Narayan Sundaresan, Jorrit-Jan Verlaan, Arjun Sahgal, Dean Chou, Charles G Fisher
STUDY DESIGN: Systematic review. OBJECTIVES: We conducted a systematic review of the literature to answer the following questions regarding the use of steroid therapy in metastatic spinal cord compression (MSCC): 1. In cases of MSCC, what is the effect of steroid administration before definitive radiotherapy or surgery on ambulatory status, bowel and bladder function and survival? 2. What steroid dosing regimens are associated with the best outcomes concerning neurological symptoms and complication prevention in cases of MSCC? SUMMARY OF BACKGROUND DATA: Currently, there is significant variation in the initial bolus dose, daily maintenance dose and duration of treatment when steroids are used as a bridge to definitive therapy for MSCC...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28435431/dioscin-induces-demethylation-of-dapk-1-and-rassf-1alpha-genes-via-the-antioxidant-capacity-resulting-in-apoptosis-of-bladder-cancer-t24-cells
#15
Qiang Zhou, Wie Song, Wei Xiao
DNA methylation at CpG rich regions often occurs at tumor suppressor gene promoters, resulting in reduced gene expression and final carcinogenesis. Hypermethylation of tumor suppressor genes, including DAPK-1 and RASSF-1α genes, have been found in patients with bladder carcinoma (BC) in some western countries. Reactive oxygen species (ROS) was reported to play a causative role in gene hypermethylation. In this study, we detected the methylation status and expression of DAPK1 and RASSF-1α genes in tissue samples from Chinese BC patients, using methylation-specific PCR, reverse transcription PCR and western blotting...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28435259/methotrexate-coupled-nanoparticles-and-magnetic-nanochemothermia-for-the-relapse-free-treatment-of-t24-bladder-tumors
#16
Marcus Stapf, Ulf Teichgräber, Ingrid Hilger
Heat-based approaches have been considered as promising tools due to their ability to directly eradicate tumor cells and/or increase the sensitivity of tumors to radiation- or chemotherapy. In particular, the heating of magnetic nanoparticles (MNPs) via an alternating magnetic field can provide a handy alternative for a localized tumor treatment. To amplify the efficacy of magnetically induced thermal treatments, we elucidated the superior tumor-destructive effect of methotrexate-coupled MNPs (MTX/MNPs) in combination with magnetic heating (nanochemothermia) over the thermal treatment alone...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28433069/assessment-of-therapeutic-effect-of-human-choriogonadotropin-in-a-chemical-cystitis-model
#17
Serhat Tanik, Kürsad Zengin, Sebahattin Albayrak, Abdullah Gurel, Muhittin Atar, Sevinc Sahin, Nevin Tuzcu, Mehmet Tuzcu, Muhammet Abdurrahim Imamoglu, Mesut Gurdal
In this study, female rats induced with chemical cystitis were administered the hormone human choriogonadotropin (HCG), and it was aimed to reveal the usefulness of HCG in the treatment of interstitial cystitis/bladder pain syndrome. The materials for this study were 32 Wistar albino female rats. The study groups were formed as follows: the cystitis group (Group 1), the cystitis + HCG protection group (Group 2), the cystitis + HCG treatment group (Group 3), and the control group (Group 4), with eight rats in each group...
May 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28433067/chloroquine-and-hydroxychloroquine-inhibit-bladder-cancer-cell-growth-by-targeting-basal-autophagy-and-enhancing-apoptosis
#18
Yi-Chia Lin, Ji-Fan Lin, Sheng-I Wen, Shan-Che Yang, Te-Fu Tsai, Hung-En Chen, Kuang-Yu Chou, Thomas I-Sheng Hwang
Chloroquine (CQ) and hydroxychloroquine (HCQ), two antimalarial drugs, are suggested to have potential anticancer properties. in the present study, we investigated the effects of CQ and HCQ on cell growth of bladder cancer with emphasis on autophagy inhibition and apoptosis induction in vitro. The results showed that CQ and HCQ inhibited the proliferation of multiple human bladder cell lines (including RT4, 5637, and T24) in a time- and dose-dependent fashion, especially in advanced bladder cancer cell lines (5637 and T24) compared to immortalized uroepithelial cells (SV-Huc-1) or other reference cancer cell lines (PC3 and MCF-7)...
May 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28430636/exploring-the-role-of-paraoxonase-2-in-bladder-cancer-analyses-performed-on-tissue-samples-urines-and-cell-cultures
#19
Tiziana Bacchetti, Davide Sartini, Valentina Pozzi, Tiziana Cacciamani, Gianna Ferretti, Monica Emanuelli
The enzyme paraoxonase-2 (PON2) is ubiquitously expressed and exerts its antiapoptotic and antioxidative functions in several intracellular compartments.The aim of this study is to investigate the role of PON2 in bladder cancer (BC). The expression levels of PON2 in paired tumor and normal bladder tissue samples and in urinary exfoliated cells from patients affected with BC and healthy donors were evaluated. Moreover, the effect of PON2 overexpression on tumor cell proliferation and susceptibility to oxidative stress was investigated in human bladder cancer cell line T24...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28427506/recent-advances-in-genitourinary-tumors-a-review-focused-on-biology-and-systemic-treatment
#20
REVIEW
Aránzazu González Del Alba, José Ángel Arranz, Javier Puente, María José Méndez-Vidal, Enrique Gallardo, Enrique Grande, Begoña Pérez-Valderrama, Enrique González-Billalabeitia, Martín Lázaro-Quintela, Álvaro Pinto, Nuria Lainez, Josep M Piulats, Emilio Esteban, José Pablo Maroto Rey, Jorge A García, Cristina Suárez
Updated information published up to 2016 regarding major advances in renal cancer, bladder cancer, and prostate cancer is here presented. Based on an ever better understanding of the genetic and molecular alterations that govern the initial pathogenic mechanisms of tumor oncogenesis, an improvement in the characterization and treatment of urologic tumors has been achieved in the past year. According to the Cancer Genome Atlas (ATLAS) project, alterations in the MET pathway are characteristics of type 1 papillary renal cell carcinomas, and activation of NRF2-ARE pathway is associated with the biologically distinct type 2...
May 2017: Critical Reviews in Oncology/hematology
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