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https://www.readbyqxmd.com/read/28944611/gene-therapy-with-the-trf1-telomere-gene-rescues-decreased-trf1-levels-with-aging-and-prolongs-mouse-health-span
#1
Aksinya Derevyanko, Kurt Whittemore, Ralph P Schneider, Verónica Jiménez, Fàtima Bosch, Maria A Blasco
The shelterin complex protects telomeres by preventing them from being degraded and recognized as double-strand DNA breaks. TRF1 is an essential component of shelterin, with important roles in telomere protection and telomere replication. We previously showed that TRF1 deficiency in the context of different mouse tissues leads to loss of tissue homeostasis owing to impaired stem cell function. Here, we show that TRF1 levels decrease during organismal aging both in mice and in humans. We further show that increasing TRF1 expression in both adult (1-year-old) and old (2-year-old) mice using gene therapy can delay age-associated pathologies...
September 24, 2017: Aging Cell
https://www.readbyqxmd.com/read/28944088/loss-of-the-vitamin-d-receptor-in-human-breast-and-prostate-cancers-strongly-induces-cell-apoptosis-through-downregulation-of-wnt-%C3%AE-catenin-signaling
#2
Yu Zheng, Trupti Trivedi, Ruby Cy Lin, Colette Fong-Yee, Rick Nolte, Jeline Manibo, Yunzhao Chen, Musharraf Hossain, Konstantin Horas, Colin Dunstan, Hong Zhou, Markus J Seibel
Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D, 1,25-dihydroxy-vitamin D [1,25(OH)2D] are mediated through binding to the vitamin D receptor (VDR). Here, we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro...
2017: Bone Research
https://www.readbyqxmd.com/read/28943768/quality-characteristics-of-tteokgalbi-with-black-rice-bran-and-organic-acid-to-substitute-synthetic-caramel-colorant
#3
Tae-Kyung Kim, Seung-Hee Hong, Su-Kyung Ku, Young-Boong Kim, Ki-Hong Jeon, Hee-Don Choi, Jong-Dae Park, Kwoan-Sik Park, Yun-Sang Choi
This study aimed to evaluate the quality characteristics of Tteokgalbi with 1% (w/w) black rice bran only (T1), or with black rice bran and one of the following four types of organic acid: ascorbic acid (T2), citric acid (T3), tartaric acid (T4), or maleic acid (T5) as a substitute for caramel colorant. Tteokgalbi with only black rice bran showed the highest (p<0.05) values of moisture content and water holding capacity (WHC), while there were no significant differences in protein content, fat content, ash content, and thiobarbituric acid reactive substance (TBARS) values in treatments and controls (p>0...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28943102/hypothalamic-pathways-regulate-the-anorectic-action-of-p-chloro-diphenyl-diselenide-in-rats
#4
Cristiani F Bortolatto, Cristina W Nogueira, Begoña Porteiro, Mónica Imbernón, Ruben Nogueiras
Behavioral studies have suggested that (p-ClPhSe)2 elicits an anorectic-like action in rats by inducing multiple effects such as satiety-enhancing effect, malaise and specific flavor; however, the molecular mechanisms underlying its anorexigenic action remain unclarified. Here, male Sprague-Dawley rats received acute and sub-chronic intraperitoneal treatments with (p-ClPhSe)2; thereafter, in vivo and ex vivo analyses were carried out. The present study reveals that the reduction of food intake resulting from a single treatment with (p-ClPhSe)2 (1mg/kg, i...
September 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28942676/epigenetics-of-cancer-associated-muscle-catabolism
#5
Ryan M Carr, Elisa Enriquez-Hesles, Rachel Lo Olson, Aminah Jatoi, Jason Doles, Martin E Fernandez-Zapico
Cancer patients are commonly affected by cachexia, a wasting process involving muscle and fat. Specifically, loss of the muscle compartment has been associated with poor prognosis and suboptimal response to therapy. Nutritional support has been ineffective in treating this process leading to investigations into the underlying molecular processes governing muscle catabolism. In this commentary, we discuss the molecular mechanisms of cancer-associated muscle metabolism and the epigenetic processes responsible for the muscle wasting phenotype...
September 25, 2017: Epigenomics
https://www.readbyqxmd.com/read/28942280/nitrate-induces-a-type-1-diabetic-profile-in-alligator-hatchlings
#6
Thea M Edwards, Heather J Hamlin, Haley Freymiller, Stephen Green, Jenna Thurman, Louis J Guillette
Type 1 diabetes (T1D) is a chronic autoimmune disease that affects 1 in 300 children by age 18. T1D is caused by inflammation-induced loss of insulin-producing pancreatic beta cells, leading to high blood glucose and a host of downstream complications. Although multiple genes are associated with T1D risk, only 5% of genetically susceptible individuals actually develop clinical disease. Moreover, a growing number of T1D cases occur in geographic clusters and among children with low risk genotypes. These observations suggest that environmental factors contribute to T1D etiology...
September 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28941206/depot-specific-response-of-adipose-tissue-to-diet-induced-inflammation-the-retinoid-related-orphan-receptor-%C3%AE-ror%C3%AE-involved
#7
Sarah Kadiri, Martine Auclair, Jacqueline Capeau, Bénédicte Antoine
OBJECTIVE: Epididymal adipose tissue (EAT), a visceral fat depot, is more closely associated with metabolic dysfunction than inguinal adipose tissue (IAT), a subcutaneous depot. This study evaluated whether the nuclear receptor RORα, which controls inflammatory processes, could be implicated. METHODS: EAT and IAT were compared in a RORα loss-of-function mouse (sg/sg) and in wild-type (WT) littermates, fed a standard diet (SD) or a Western diet (WD), to evaluate the impact of RORα expression on inflammatory status and on insulin sensitivity (IS) of each fat depot according to the diet...
September 20, 2017: Obesity
https://www.readbyqxmd.com/read/28938784/immunocastration-as-an-alternative-to-caponization-evaluation-of-its-effect-on-body-and-bone-development-and-on-meat-color-and-composition
#8
M A G Quaresma, I C Antunes, M F Ribeiro, S Prazeres, R J B Bessa, P Martins da Costa
Caponization is associated with some morbidity and mortality, which contributes to important economic losses. This practice is executed without any pain relief (neither anesthesia nor analgesia) and can be painful and without consideration of animal welfare. On the other hand, immunocastration accomplished by Improvac and Bovipriva in pigs and cattle represents a noninvasive procedure, and for that reason is regarded as an alternative with improved animal welfare. This study includes 4 experimental groups consisting of capons, slips, roosters, and birds submitted to the Improvac treatment...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938473/the-role-of-episodic-postprandial-peptides-in-exercise-induced-compensatory-eating
#9
Catherine Gibbons, John E Blundell, Phillipa Caudwell, Dominic-Luc Webb, Per M Hellström, Erik Näslund, Graham Finlayson
Purpose: Prolonged physical activity gives rise to variable degrees of body weight and fat loss, and is associated with variability in appetite control (hunger and energy intake). Whether these effects are modulated by postprandial 'episodic' peptides is unclear. We examined the role of postprandial peptide response in compensatory eating during 12-weeks aerobic exercise and in response to high (HFLC) and low fat (LFHC) meals. Methods: 32 overweight/obese individuals - 16 completed 12-weeks aerobic exercise and 16 were age- and BMI-matched non-exercising controls...
August 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938366/-camouflaging-cleft-lip-scar-using-follicular-unit-extraction-hair-transplantation-combined-with-autologous-fat-grafting
#10
Osman Akdag, Nuh Evin, Mehtap Karamese, Zekeriya Tosun
BACKGROUND: The scar that occurs after cleft lip surgery poses a serious cosmetic problem. One of the methods used to solve this problem in adult male patients is hair transplantation. However, satisfactory results with this method cannot always be achieved due to possible graft loss. The corrective feature of fat grafting has been reported in many studies. The aim of this report is to share our results with hair transplantation combined with fat grafting in patients with cleft lip. METHODS: This study included 20 patients who had both a scar and alopecia in the cleft lip area...
September 15, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28938290/body-composition-changes-in-severely-burned-children-during-icu-hospitalization
#11
Janos Cambiaso-Daniel, Ioannis Malagaris, Eric Rivas, Gabriel Hundeshagen, Charles D Voigt, Elizabeth Blears, Ron P Mlcak, David N Herndon, Celeste C Finnerty, Oscar E Suman
OBJECTIVES: Prolonged hospitalization due to burn injury results in physical inactivity and muscle weakness. However, how these changes are distributed among body parts is unknown. The aim of this study was to evaluate the degree of body composition changes in different anatomical regions during ICU hospitalization. DESIGN: Retrospective chart review. SETTING: Children's burn hospital. PATIENTS: Twenty-four severely burned children admitted to our institution between 2000 and 2015...
September 21, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28937286/comparing-subjective-and-objective-image-quality-at-two-different-radiation-exposure-ranges-of-the-paranasal-sinus-ct-examinations-using-a-volumetric-320-row-detector-ct-system
#12
Berhan Pirimoglu, Recep Sade, Muhammed Sedat Sakat, Hayri Ogul, Suat Eren, Mecit Kantarci
OBJECTIVES: To evaluate image quality of protocol including 135 kVp, 5 mAs and 80 kVp, 5 mAs in the paranasal sinus CT examinations using single volumetric 320-row multidetector CT technique. METHODS: From September to December 2016, both of our control group including 135 kVp and 5 mAs and our study group including 80 kVp and 5 mAs paranasal CT protocols were simultaneously performed on 40 patients using single volumetric 320-row multidetector CT device. Image quality for bony structures, air-filled structures and soft tissues were independently assessed for each group by three blinded observers using a 3-point grading scale (0 = not diagnostic, 1 = partially diagnostic, 2 = diagnostic)...
September 21, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28933748/dietary-composition-independent-of-weight-loss-in-the-management-of-non-alcoholic-fatty-liver-disease
#13
REVIEW
Tannaz Eslamparast, Puneeta Tandon, Maitreyi Raman
Poor dietary composition is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). The majority of NAFLD patients follow diets with overconsumption of simple carbohydrates, total and saturated fat, with reduced intake of dietary fiber and omega-3 rich foods. Although lifestyle modifications including weight loss and exercise remain the keystone of NAFLD management, modifying dietary composition with or without a calorie-restricted diet may also be a feasible and sustainable strategy for NAFLD treatment...
July 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28932410/quantitative-characterization-of-optic-nerve-atrophy-in-patients-with-multiple-sclerosis
#14
Robert L Harrigan, Alex K Smith, Bailey Lyttle, Bailey Box, Bennett A Landman, Francesca Bagnato, Siddharama Pawate, Seth A Smith
BACKGROUND: Optic neuritis (ON) is one of the most common presentations of multiple sclerosis (MS). Magnetic resonance imaging (MRI) of the optic nerves is challenging because of retrobulbar motion, orbital fat and susceptibility artifacts from maxillary sinuses; therefore, axonal loss is investigated with the surrogate measure of a single heuristically defined point along the nerve as opposed to volumetric investigation. OBJECTIVE: The objective of this paper is to derive optic nerve volumetrics along the entire nerve length in patients with MS and healthy controls in vivo using high-resolution, clinically viable MRI...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28931532/genetic-variation-of-habitual-coffee-consumption-and-glycemic-changes-in-response-to-weight-loss-diet-intervention-the-preventing-overweight-using-novel-dietary-strategies-pounds-lost-trial
#15
Liyuan Han, Wenjie Ma, Dianjianyi Sun, Yoriko Heianza, Tiange Wang, Yan Zheng, Tao Huang, Donghui Duan, J George A Bray, Catherine M Champagne, Frank M Sacks, Lu Qi
Background: Coffee consumption has been associated with glucose metabolism and risk of type 2 diabetes.Objective: We examined whether the genetic variation determining habitual coffee consumption affected glycemic changes in response to weight-loss dietary intervention.Design: A genetic risk score (GRS) was calculated based on 8 habitual coffee consumption-associated single nucleotide polymorphisms. We used general linear models to test changes in glycemic traits in groups randomly assigned to high- and low-fat diets according to tertiles of the GRS...
September 20, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28930668/aspects-of-sexual-precocity-and-morphometry-of-uterus-placenta-and-embryos-fetuses-in-piau-breed-and-commercial-line-gilts
#16
José Carlos Montes, Jurandy Mauro Penitente-Filho, Simone Eliza Facioni Guimarães, Paulo Sávio Lopes, Breno Soares Camilo, Hugo Hideki Shiomi, Daniel Araújo Lima, Rogério Oliveira Pinho, Jhonata Vieira Tavares do Nascimento Pereira, Denise Silva Okano, Karine Assis Costa, José Domingos Guimarães
In view of the importance of the genetic material of local breeds in the swine industry and the lack of information about reproductive performance of Piau females, two experiments were conducted to evaluate puberty and sexual maturity as well as the morphometry of embryos/fetuses, placenta and uterus during the first 90 days of gestation in Piau breed and Commercial line gilts. In experiment I, 37 Piau and 25 commercial line gilts were used. From the 120 days of age, detection of estrus was performed using mature boars from the first to third estrus of each gilt...
September 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/28929907/management-of-obesity-after-spinal-cord-injury-a-systematic-review
#17
M H Shojaei, S M Alaviniaa, B C Craven
CONTEXT: Individuals with chronic spinal cord injury (SCI) are susceptible to central and visceral obesity and it's metabolic consequences; consensus based guidelines for obesity management after SCI have not yet been stablished. OBJECTIVES: To identify and compare effective means of obesity management among SCI individuals. METHODS: This systematic review included English and non-English articles, published prior to April 2017 found in the PubMed/Medline, Embase, CINAHL Psychinfo and Cochrane databases...
September 20, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28929308/influence-of-obesity-on-experimental-periodontitis-in-rats-histopathological-histometric-and-immunohistochemical-study
#18
Elizangela Partata Zuza, Valdir Gouveia Garcia, Letícia Helena Theodoro, Edilson Ervolino, Luiz Fernando Veloso Favero, Mariéllen Longo, Fernando Salimon Ribeiro, Alex Tadeu Martins, Luís Carlos Spolidorio, José Antônio Sampaio Zuanon, Benedicto Egbert Corrêa de Toledo, Juliana Rico Pires
OBJECTIVES: This study assessed the influence of obesity on the progression of ligature-induced periodontitis in rats. MATERIALS AND METHODS: Forty-eight adult Wistar rats were randomly divided into two groups: the HL group (n = 24) was fed high-fat animal food to induce obesity, and the NL group (n = 24) was fed normolipidic animal food. Obesity was induced within a period of 120 days, and the induction of experimental periodontitis (EP) was subsequently performed for 30 days...
September 19, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28929278/effect-and-mechanisms-of-diabetes-resolution-according-to-the-range-of-gastric-resection-and-the-length-of-anastomosis-in-animal-models-implication-for-gastric-cancer-surgery-in-patients-with-diabetes-mellitus
#19
Yeon-Ju Huh, Young-Gil Son, Tae-Han Kim, Ji-Ho Park, Tae-Jung Oh, Boram Choi, Jimin Min, Young Min Cho, Han-Kwang Yang, Hyuk-Joon Lee
BACKGROUND: To examine the effect and mechanism of Roux-en-Y gastric bypass (RYGB) on the improvement of diabetes according to the length of anastomosis and the gastric pouch volume in an animal model. METHODS: Glucose intolerance was induced with a high-fat diet for 3 months in Sprague-Dawley rats. The animals were subjected to conventional RYGB (cRYGB; 5% gastric pouch with 15-cm Roux limb, 40-cm biliopancreatic limb; n = 9), short-limb RYGB (sRYGB; 5%, 8, 4 cm; n = 9), fundus-sparing RYGB (fRYGB; 30%, 8, 4 cm; n = 9), or sham operation (n = 9)...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28929063/lymph-node-central-necrosis-on-the-computed-tomography-as-the-predictor-of-the-extra-capsular-spread-in-metastatic-head-and-neck-squamous-cell-carcinoma
#20
Aditi Sharma, Ashwin Ashok Jaiswal, Girish Umredkar, Ratiram Barle, Neeta Sharma, Praveer Kumar Banerjee, Amrish Kumar Garg, Ravindranath Membally
The aim of this study is to investigate the relationship between the presence of the cervical lymph node with central necrosis as on the preoperative imaging and postoperative histopathological identification of the lymph node extra capsular spread. This study is a prospective study conducted at J.L.N. Hospital and Research Centre, Bhilai (C.G), from August 2011 to January 2014. Thirty patients with metastatic head and neck squamous cell carcinoma were enrolled. All candidates were subjected to a detailed history taking and clinical examination...
September 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
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