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https://www.readbyqxmd.com/read/29777135/n-methyl-d-aspartate-receptor-subtype-2b-antagonist-ro-25-6981-attenuates-neuropathic-pain-by-inhibiting-postsynaptic-density-95-expression
#1
Ling-Er Huang, Shao-Hui Guo, Lalita Thitiseranee, Yan Yang, Yan-Feng Zhou, Yong-Xing Yao
Postsynaptic density-95 (PSD-95) is a synaptic scaffolding protein that plays a crucial role in the development of neuropathic pain. However, the underlying mechanism remains unclear. To address the role of PSD-95 in N-methyl-D-aspartate receptor subtype 2B (NR2B) -mediated chronic pain, we investigated the relationship between PSD-95 activation and NR2B function in the spinal cord, by using a rat model of sciatic nerve chronic constriction injury (CCI). We demonstrate that the expression levels of total PSD-95 and cAMP response element binding protein (CREB), as well as phosphorylated NR2B, PSD-95, and CREB, in the spinal dorsal horn, and the interaction of NR2B with PSD-95 were increased in the CCI animals...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776950/clinical-effects-and-safety-of-electroacupuncture-for-the-treatment-of-post-stroke-depression-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#2
Xue-Bin Li, Jie Wang, An-Ding Xu, Jian-Min Huang, Lan-Qing Meng, Rui-Ya Huang, Jing Xu
OBJECTIVE: The aim of this systematic review was to assess the efficacy/effectiveness and safety of electroacupuncture (EA) in the treatment of post-stroke depression (PSD). METHODS: A comprehensive literature search in the Pubmed, Embase, CENTRAL, ISI Web of Science, CNKI and Wanfang databases was conducted, and all relevant randomised controlled trials (RCTs) were screened for eligibility by two independent reviewers. The Cochrane Collaboration's tool and Jadad score were used to assess the risk of bias of included studies, and only RCTs scoring ≥3 were included in a meta-analysis...
May 18, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29772081/a-photon-source-model-based-on-particle-transport-in-a-parameterized-accelerator-structure-for-monte-carlo-dose-calculations
#3
Yoshiki Ishizawa, Suguru Dobashi, Noriyuki Kadoya, Kengo Ito, Takahito Chiba, Yoshiki Takayama, Kiyokazu Sato, Ken Takeda
PURPOSE: An accurate source model of a medical linear accelerator is essential for Monte Carlo (MC) dose calculations. This study aims to propose an analytical photon source model based on particle transport in parameterized accelerator structures, focusing on a more realistic determination of linac photon spectra compared to existing approaches. METHODS: We designed the primary and secondary photon sources based on the photons attenuated and scattered by a parameterized flattening filter...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29759141/elevated-plasma-macrophage-migration-inhibitor-factor-as-a-risk-factor-for-the-development-of-post-stroke-depression-in-ischemic-stroke
#4
Tingting Xu, Shuang Pu, Ying Ni, Mingqing Gao, Xuemei Li, Xianwei Zeng
BACKGROUND: Macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory responses, has been reported to link to the pathophysiology of cardiovascular disease and depression. The aim of this study was to test the possible association between plasma MIF and the development of post-stroke depression (PSD) in Chinese patients with acute ischemic stroke (AIS). METHODS: The first-ever AIS patients who were hospitalized at Affiliated Hospital of Weifang Medical College during the period from November 2015 to September 2017 were included...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29758870/effect-of-the-micro-flocculation-stage-on-the-flocculation-sedimentation-process-the-role-of-shear-rate
#5
Zhenbei Wang, Jun Nan, Xiaoyu Ji, Yueming Yang
Dynamic analysis on the variation of particle size distribution (PSD) and the fractal characteristics of PSD (Df ) were investigated to better understand the continuous procedure of the floc growth and optimize the control of flocculation process. It was found that the flocculation process could be divided into three stages, i.e., the micro-flocculation stage, the growth stage and the steady (or breakage) stage. As the stage which is crucial to the morphology of micro-flocs (the building blocks of large flocs), the micro-flocculation stage plays an important role on flocculation/sedimentation process...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751422/spatiotemporal-variability-of-suspended-sediment-particle-size-in-a-mixed-land-use-watershed
#6
Elliott Kellner, Jason A Hubbart
Given existing knowledge gaps, there is a need for research that quantitatively characterizes spatiotemporal variation of suspended sediment particle size distribution (PSD) in contemporary watersheds. A five-year study was conducted in a representative watershed of the central United States utilizing a nested-scale experimental watershed study design, comprising five gauging sites partitioning the catchment into five sub-watersheds. Streamwater grab samples were collected four times per week, at each gauging site, for the duration of the study period (Oct...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29750715/visual-field-tests-for-glaucoma-patients-with-initial-macular-damage-comparison-between-frequency-doubling-technology-and-standard-automated-perimetry-using-24-2-or-10-2-visual-fields
#7
Hae-Young Lopilly Park, Jiyoung Lee, Chan Kee Park
PURPOSE: To compare standard automated perimetry (SAP) and frequency-doubling technology (FDT) perimetry for detecting macular damage in glaucoma. METHODS: One-hundred-twelve glaucomatous eyes with localized retinal nerve fiber layer (RNFL) defects on red-free photographs and corresponding macular ganglion cell/inner plexiform layer (mGC/IPL) thinning on the deviation map of macular optical coherence tomography (OCT), and thirty-five healthy eyes were enrolled in the study...
May 10, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29747670/the-efficacy-and-safety-of-jiedu-tongluo-granules-for-treating-post-stroke-depression-with-qi-deficiency-and-blood-stasis-syndrome-study-protocol-for-a-randomized-controlled-trial
#8
Ai-Mei Zhao, Wen-Ran Qiu, Li-Jun Mao, Jun-Guo Ren, Li Xu, Ming-Jiang Yao, Kellie Bilinksi, Dennis Chang, Jian-Xun Liu
BACKGROUND: Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chinese medicine has been used to treat PSD with few side effects. The aim of this study is to evaluate the efficacy and safety of Jiedu Tongluo granules for treating PSD with qi deficiency and blood stasis syndrome...
May 10, 2018: Trials
https://www.readbyqxmd.com/read/29742266/efficacy-acceptability-and-tolerability-of-antidepressant-treatments-for-patients-with-post-stroke-depression-a-network-meta-analysis
#9
B Qin, H Chen, W Gao, L B Zhao, M J Zhao, H X Qin, W Chen, L Chen, M X Yang
The aim of this study was to investigate the efficacy, acceptability, and tolerability of antidepressants in treating post-stroke depression (PSD) by performing a network meta-analysis of randomized controlled trials of the current literature. Eligible studies were retrieved from online databases, and relevant data were extracted. The primary outcome was efficacy as measured by the mean change in overall depressive symptoms. Secondary outcomes included discontinued treatment for any reason and specifically due to adverse events...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29740285/ovarian-function-modulates-the-effects-of-long-chain-polyunsaturated-fatty-acids-on-the-mouse-cerebral-cortex
#10
Jose L Herrera, Lara Ordoñez-Gutierrez, Gemma Fabrias, Josefina Casas, Araceli Morales, Guadalberto Hernandez, Nieves G Acosta, Covadonga Rodriguez, Luis Prieto-Valiente, Luis M Garcia-Segura, Rafael Alonso, Francisco G Wandosell
Different dietary ratios of n -6/ n -3 long-chain polyunsaturated fatty acids (LC-PUFAs) may alter brain lipid profile, neural activity, and brain cognitive function. To determine whether ovarian hormones influence the effect of diet on the brain, ovariectomized and sham-operated mice continuously treated with placebo or estradiol were fed for 3 months with diets containing low or high n -6/ n -3 LC-PUFA ratios. The fatty acid (FA) profile and expression of key neuronal proteins were analyzed in the cerebral cortex, with intact female mice on standard diet serving as internal controls of brain lipidome composition...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29735530/nmda-receptor-dependent-dephosphorylation-of-serine-387-in-argonaute-2-increases-its-degradation-and-affects-dendritic-spine-density-and-maturation
#11
Nicolas Paradis-Isler, Jannic Boehm
Argonaute (AGO) proteins are essential components of the microRNA (miRNA) pathway. AGO proteins are loaded with miRNAs to target mRNAs and thereby regulate mRNA stability and protein translation. As such, AGO proteins are important actors in controlling local protein synthesis, for instance, at dendritic spines and synapses. Although miRNA-mediated regulation of dendritic mRNAs has become a focus of intense interest over the past years, the mechanisms regulating neuronal AGO proteins remain largely unknown...
May 7, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29729322/methamphetamine-augment-hiv-1-tat-mediated-memory-deficits-by-altering-the-expression-of-synaptic-proteins-and-neurotrophic-factors
#12
Anantha Ram Nookala, Daniel C Schwartz, Nitish S Chaudhari, Alexy Glazyrin, Edward B Stephens, Nancy E J Berman, Anil Kumar
Methamphetamine (METH) abuse is common among individuals infected with HIV-1 and has been shown to affect HIV replication and pathogenesis. These HIV-1 infected individuals also exhibit greater neuronal injury and higher cognitive decline. HIV-1 proteins, specifically gp120 and HIV-1 Tat, have been earlier shown to affect neurocognition. HIV-1 Tat, a viral protein released early during HIV-1 replication, contributes to HIV-associated neurotoxicity through various mechanisms including production of pro-inflammatory cytokines, reactive oxygen species and dysregulation of neuroplasticity...
May 2, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29723577/ampa-receptor-dependent-glutamatergic-signaling-is-present-in-the-carotid-chemoreceptor
#13
Yuzhen Liu, Chaohong Li, Xianglei Jia, Lu Huang, J Woodrow Weiss
Exposure to both sustained and intermittent hypoxia for as little as a day produces sustained augmentation of carotid chemoreceptor sensitivity; however, the molecular basis for this chemoreflex plasticity remains uncertain. We previously reported that NMDA receptor dependent glutamatergic signaling in rat carotid body played a role in altered hypoxic sensitivity after exposure to cyclic intermittent hypoxia (CIH). Here we found that mRNAs of multiple AMPA and Kainate glutamate receptors were expressed in rat carotid body...
April 30, 2018: Neuroscience
https://www.readbyqxmd.com/read/29723552/pi3k-akt-gsk3%C3%AE-induced-creb-activation-ameliorates-arsenic-mediated-alterations-in-nmda-receptors-and-associated-signaling-in-rat-hippocampus-neuroprotective-role-of-curcumin
#14
Pranay Srivastava, Yogesh K Dhuriya, Vivek Kumar, Akriti Srivastava, Richa Gupta, Rajendra K Shukla, Rajesh S Yadav, Hari N Dwivedi, Aditya B Pant, Vinay K Khanna
Protective efficacy of curcumin in arsenic induced NMDA receptor dysfunctions and PI3 K/Akt/ GSK3β signalling in hippocampus has been investigated in vivo and in vitro. Exposure to sodium arsenite (in vivo - 20 mg/kg, body weight p.o. for 28 days; in vitro - 10 µM for 24 hrs) and curcumin (in vivo - 100 mg/kg body weight p.o. for 28 days; in vitro - 20 µM for 24 hrs) was carried out alone or simultaneously. Treatment with curcumin ameliorated sodium arsenite induced alterations in the levels of NMDA receptors, its receptor subunits and synaptic proteins - pCaMKIIα, PSD-95 and SynGAP both in vivo and in vitro...
April 30, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29720403/urokinase-type-plasminogen-activator-upa-promotes-ezrin-mediated-reorganization-of-the-synaptic-cytoskeleton-in-the-ischemic-brain
#15
Paola Merino, Ariel Diaz, Luis Guillermo Manrique, Lihong Cheng, Manuel Yepes
Synaptic repair in the ischemic brain is a complex process that requires reorganization of the actin cytoskeleton.  Ezrin, radixin and moesin (ERM) are a group of evolutionary conserved proteins that link the plasma membrane to the actin cytoskeleton and act as scaffolds for signaling transduction.  Urokinase-type plasminogen activator (uPA) is a serine proteinase that upon binding to the urokinase-type plasminogen activator receptor (uPAR) catalyzes the conversion of plasminogen into plasmin on the cell surface and activates intracellular signaling pathways...
May 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29720216/decreased-level-of-irisin-a-skeletal-muscle-cell-derived-myokine-is-associated-with-post-stroke-depression-in-the-ischemic-stroke-population
#16
Wen-Jun Tu, Han-Cheng Qiu, Qiang Liu, Xuemei Li, Ji-Zong Zhao, Xianwei Zeng
BACKGROUND: Depression is a frequent mood disorder in stroke patient. Our aim was to determine irisin levels in serum and investigate their associations with post-stroke depression (PSD) in a 6-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS). METHODS: The subjects were first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up...
May 2, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29716921/a-multi-center-phase-1-trial-of-ipilimumab-in-myelodysplastic-syndrome-patients-following-hypomethylating-agent-failure
#17
Amer M Zeidan, Hanna A Knaus, Tara M Robinson, Andrea Mh Towlerton, Edus H Warren, Joshua F Zeidner, Amanda L Blackford, Amy S Duffield, David Rizzieri, Mark G Frattini, Yair M Levy, Mark A Schroeder, Anna Ferguson, Katherine E Sheldon, Amy E DeZern, Ivana Gojo, Steven D Gore, Howard Streicher, Leo Luznik, B Douglas Smith
PURPOSE: After failure of hypomethylating agents (HMAs), patients with myelodysplastic syndromes (MDS) have dismal survival and no approved treatment options. EXPERIMENTAL DESIGN: We conducted a phase 1b investigator-initiated trial of ipilimumab in patients with high-risk MDS that have failed HMAs. Patients received monotherapy at 2 dose-levels (DL; 3 and 10mg/kg) with an induction and a maintenance phase. Toxicities and responses were evaluated with CTCAE.4 and IWG-2006 criteria...
May 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29716037/validation-of-the-particle-size-distribution-obtained-with-the-laser-in-situ-scattering-and-transmission-lisst-meter-in-flow-through-mode
#18
Emmanuel Boss, Nils Haëntjens, Toby K Westberry, Lee Karp-Boss, Wayne H Slade
High spatial and temporal resolution estimates of the particle size distribution (PSD) in the surface ocean can enable improved understanding of biogeochemistry and ecosystem dynamics. Oceanic PSD measurements remain rare due to the time-consuming, manual sampling methods of common particle sizing instruments. Here, we evaluate the utility of measuring particle size data at high spatial resolution with a commercially-available submersible laser diffraction particle sizer (LISST-100X, Sequoia Scientific), operating in an automated mode with continuously flowing seawater...
April 30, 2018: Optics Express
https://www.readbyqxmd.com/read/29716016/optimized-criteria-for-angular-parameter-selection-for-the-chin-shifrin-integral-transform-inversion
#19
Wenjing Wang, Wei Liu, Shuaishuai Tan, Yajing Wang, Jin Shen, John C Thomas
The accuracy of the particle size distribution (PSD) recovered from laser diffraction measurements by the Chin-Shifrin integral transform algorithm is reduced unless the proper angular parameters, including the lower and upper angular integration limits (θmax and θmin ) and the angular resolution (Δθ), are used. To determine the selection criteria for these parameters, we use two metrics: the inversion error of the non-negative PSD, ε1 , and the fitting error of the scattered laser light, ε2 . By studying the variation of the minimum θmax and ε2 with the particle size at different inversion errors, and by analyzing the inversion error, as θmin and Δθ are varied, the optimized selection criteria for the minimum θmax , θmin and Δθ are obtained respectively...
April 16, 2018: Optics Express
https://www.readbyqxmd.com/read/29715511/increased-neuroligin-2-levels-in-the-postsynaptic-membrane-in-spinal-dorsal-horn-may-contribute-to-postoperative-pain
#20
Ruijuan Guo, Huili Li, Xueyang Li, Yuqing Sun, Huihui Miao, Danxu Ma, Fangxiao Hong, Ye Zhang, Yun Guan, Junfa Li, Ming Tian, Yun Wang
Neuroligin 2 is a synaptic cell adhesion molecule that is mainly located in inhibitory synapses and is crucial in the regulation of synapse function through protein-protein interactions. However, researchers have not clearly determined whether neuroligin 2 is involved in the development of postoperative pain. In the current study, Western blot, immunofluorescence staining and co-immunoprecipitation were used to examine the critical role of neuroligin 2 in postoperative pain hypersensitivity. A small interfering ribonucleic acid (siRNA)-targeting neuroligin 2 was used to inhibit neuroligin 2 expression...
April 30, 2018: Neuroscience
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