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https://www.readbyqxmd.com/read/29332249/correlation-of-flow-density-as-measured-using-optical-coherence-tomography-angiography-with-structural-and-functional-parameters-in-glaucoma-patients
#1
Maged Alnawaiseh, Larissa Lahme, Viktoria Müller, André Rosentreter, Nicole Eter
PURPOSE: To evaluate the correlation between flow density, as measured by optical coherence tomography angiography (OCTA), and structural and functional parameters in patients with open-angle glaucoma. METHODS: Thirty-four eyes of 34 patients with open-angle glaucoma and 35 eyes of 35 healthy subjects were prospectively included in this study. OCTA was performed using RTVue XR Avanti with AngioVue. The macula was imaged with a 3 × 3 mm scan and the optic nerve head (ONH) with a 4...
January 13, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29330327/signal-complexity-of-human-intracranial-eeg-tracks-successful-associative-memory-formation-across-individuals
#2
Timothy C Sheehan, Vishnu Sreekumar, Sara K Inati, Kareem A Zaghloul
Memory performance is highly variable between individuals. Most studies examining human memory, however, have largely focused on the neural correlates of successful memory formation within individuals, rather than the differences between them. As such, what gives rise to this variability is poorly understood. Here, we examined intracranial EEG (iEEG) recordings captured from 43 participants (23 male) implanted with subdural electrodes for seizure monitoring as they performed a paired-associates verbal memory task...
January 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29328286/information-weighted-constrained-regularization-for-particle-size-distribution-recovery-in-multiangle-dynamic-light-scattering
#3
Min Xu, Jin Shen, John C Thomas, Yu Huang, Xinjun Zhu, Luis A Clementi, Jorge R Vega
In particle size measurement with dynamic light scattering (DLS), it is difficult to get an accurate recovery of a bimodal particle size distribution (PSD) with a peak position ratio less than ~2:1, especially when large particles (>350nm) are present. This is due to the inherent noise in the autocorrelation function (ACF) data and the scarce utilization of PSD information during the inversion process. In this paper, the PSD information distribution in the ACF data is investigated. It was found that the initial decay section of the ACF contains more information, especially for a bimodal PSD...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29325799/elevated-circulating-homocysteine-and-high-sensitivity-c-reactive-protein-jointly-predicts-post-stroke-depression-among-chinese-patients-with-acute-ischemic-stroke
#4
Jieyun Yin, Chongke Zhong, Zhengbao Zhu, Xiaoqing Bu, Tan Xu, Libing Guo, Xuemei Wang, Jintao Zhang, Yong Cui, Dong Li, Jianhui Zhang, Zhong Ju, Chung-Shiuan Chen, Jing Chen, Yonghong Zhang, Jiang He
BACKGROUND: Homocysteine (HCY) and high sensitivity C reactive protein (hs-CRP) were suggested to be involved in post-stroke depression (PSD), which is a frequent mood disorder after stroke. However, the combined effect of HCY and hs-CRP on PSD remains unclear. METHODS: A total of 598 acute ischemic stroke patients from 7 of 26 centers participating in the China Antihypertensive Trial in Acute Ischemic Stroke with HCY or hs-CRP measurements were included in this analysis...
January 8, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29321508/thrombospondin-1-secreted-by-human-umbilical-cord-blood-derived-mesenchymal-stem-cells-rescues-neurons-from-synaptic-dysfunction-in-alzheimer-s-disease-model
#5
Dong Hyun Kim, Hoon Lim, Dahm Lee, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Jeong Su Oh, Hyun Ho Hwang, Hong Bae Jeon
Alzheimer's disease (AD) is an incurable neurodegenerative disease characterised clinically by learning and memory impairments. Amyloid beta (Aβ) peptide-induced synaptic dysfunction is a pathological process associated with early-stage AD. Here, we show that paracrine action of human umbilical cord blood-derived-mesenchymal stem cells (hUCB-MSCs) protects the hippocampus from synaptic-density loss in in vitro and in vivo AD models. To identify paracrine factors underlying this rescue effect, we analysed hUCB-MSCs' secretome co-cultured with Aβ42-treated mouse hippocampal neurons...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317733/in-vivo-sted-microscopy-visualizes-psd95-sub-structures-and-morphological-changes-over-several-hours-in-the-mouse-visual-cortex
#6
Waja Wegner, Alexander C Mott, Seth G N Grant, Heinz Steffens, Katrin I Willig
The post-synaptic density (PSD) is an electron dense region consisting of ~1000 proteins, found at the postsynaptic membrane of excitatory synapses, which varies in size depending upon synaptic strength. PSD95 is an abundant scaffolding protein in the PSD and assembles a family of supercomplexes comprised of neurotransmitter receptors, ion channels, as well as signalling and structural proteins. We use superresolution STED (STimulated Emission Depletion) nanoscopy to determine the size and shape of PSD95 in the anaesthetised mouse visual cortex...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311144/differentiation-and-characterization-of-excitatory-and-inhibitory-synapses-by-cryo-electron-tomography-and-correlative-microscopy
#7
Chang-Lu Tao, Yun-Tao Liu, Rong Sun, Bin Zhang, Lei Qi, Sakar Shivakoti, Chong-Li Tian, Peijun Zhang, Pak-Ming Lau, Z Hong Zhou, Guo-Qiang Bi
As key functional units in neural circuits, different types of neuronal synapses play distinct roles in brain information processing, learning and memory. Synaptic abnormalities are believed to underlie various neurological and psychiatric disorders. Here, by combining cryo-electron tomography and cryo-correlative light and electron microscopy, we distinguished intact excitatory and inhibitory synapses of cultured hippocampal neurons, and visualized the in situ three-dimensional organization of synaptic organelles and macromolecules in their native state...
January 8, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29305310/a-prospective-longitudinal-study-to-investigate-corneal-hysteresis-as-a-risk-factor-for-predicting-development-of-glaucoma
#8
Carolina N Susanna, Alberto Diniz-Filho, Fábio B Daga, Bianca N Susanna, Feilin Zhu, Nara G Ogata, Felipe A Medeiros
PURPOSE: To investigate the role of corneal hysteresis (CH) as a risk factor for development of glaucoma. DESIGN: Prospective observational cohort study. METHODS: Two-hundred and eighty-seven eyes of 199 patients suspected of having glaucoma followed for an average of 3.9 ± 1.8 years. All eyes had normal visual fields at baseline. Development of glaucoma was defined as occurrence of 3 consecutive abnormal standard automated perimetry tests during follow-up, defined as pattern standard deviation (PSD) <5%, and/or Glaucoma Hemifield Test outside normal limits...
January 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29302912/development-of-an-indicator-for-characterizing-particle-size-distribution-and-quality-of-stormwater-runoff
#9
Qian Wang, Qionghua Zhang, Mawuli Dzakpasu, Bin Lian, Yaketon Wu, Xiaochang C Wang
Stormwater particles washed from road-deposited sediments (RDS) are traditionally characterized as either turbidity or total suspended solids (TSS). Although these parameters are influenced by particle sizes, neither of them characterizes the particle size distribution (PSD), which is of great importance in pollutant entrainment and treatment performance. Therefore, the ratio of turbidity to TSS (Tur/TSS) is proposed and validated as a potential surrogate for the bulk PSD and quality of stormwater runoff. The results show an increasing trend of Tur/TSS with finer sizes of both RDS and stormwater runoff...
January 5, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29299953/general-self-efficacy-as-a-driving-factor-of-post-stroke-depression-a-longitudinal-study
#10
Matthias Volz, Manuel C Voelkle, Katja Werheid
Post-stroke depression (PSD) is the most common psychiatric condition after stroke, affecting one third of survivors. Despite identification of meaningful predictors, knowledge about the interplay between these factors remains fragmentary. General self-efficacy (GSE) is closely linked to PSD, yet direction and magnitude of this relationship remains unclear. The authors assessed the relationship between GSE and depression during the first two years post-stroke while controlling for stable inter-individual differences using continuous time (CT) structural equation modelling (SEM)...
January 4, 2018: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29285067/morphologic-characteristics-and-clinical-significance-of-the-macular-sparing-area-in-patients-with-retinitis-pigmentosa-as-revealed-by-multicolor-imaging
#11
Guodong Liu, Qing Du, Khusbu Keyal, Fang Wang
Retinitis pigmentosa (RP) is an inherited retinal disease caused by the degeneration of photoreceptors and retinal pigment epithelium cells within the eye. The present study aimed to evaluate the effectiveness of multicolor imaging as a novel technique for the depiction of morphological features in the macular area of patients with RP. Additionally, the correlation between the size of the macular-sparing area and the best corrected visual acuity (BCVA), central visual field function and subfoveal choroidal thickness (SFCT) was analyzed...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284046/irsp53-accumulates-at-the-postsynaptic-density-under-excitatory-conditions
#12
Ayse Dosemeci, Amelia Burch, Hannah Loo, Dana Toy, Jung-Hwa Tao-Cheng
IRSp53 (BAIAP2) is an abundant protein at the postsynaptic density (PSD) that binds to major PSD scaffolds, PSD-95 and Shanks, as well as to F-actin. The distribution of IRSp53 at the PSD in cultured hippocampal neurons was examined under basal and excitatory conditions by immuno-electron microscopy. Under basal conditions, label for IRSp53 is concentrated at the PSD. Upon depolarization by application of a medium containing 90 mM K+, the intensity of IRSp53 label at the PSD increased by 36±7%. Application of NMDA (50 μM) yielded 53±1% increase in the intensity of IRSp53 label at the PSD compared to controls treated with APV, an NMDA antagonist...
2017: PloS One
https://www.readbyqxmd.com/read/29281827/synaptic-targeting-and-function-of-sapaps-mediated-by-phosphorylation-dependent-binding-to-psd-95-maguks
#13
Jinwei Zhu, Qingqing Zhou, Yuan Shang, Hao Li, Mengjuan Peng, Xiao Ke, Zhuangfeng Weng, Rongguang Zhang, Xuhui Huang, Shawn S C Li, Guoping Feng, Youming Lu, Mingjie Zhang
The PSD-95/SAPAP/Shank complex functions as the major scaffold in orchestrating the formation and plasticity of the post-synaptic densities (PSDs). We previously demonstrated that the exquisitely specific SAPAP/Shank interaction is critical for Shank synaptic targeting and Shank-mediated synaptogenesis. Here, we show that the PSD-95/SAPAP interaction, SAPAP synaptic targeting, and SAPAP-mediated synaptogenesis require phosphorylation of the N-terminal repeat sequences of SAPAPs. The atomic structure of the PSD-95 guanylate kinase (GK) in complex with a phosphor-SAPAP repeat peptide, together with biochemical studies, reveals the molecular mechanism underlying the phosphorylation-dependent PSD-95/SAPAP interaction, and it also provides an explanation of a PSD-95 mutation found in patients with intellectual disabilities...
December 26, 2017: Cell Reports
https://www.readbyqxmd.com/read/29281196/effects-of-prolonged-and-repeated-immersions-on-heart-rate-variability-and-complexity-in-military-divers
#14
Nathaniel T Berry, Laurie Wideman, Christopher K Rhea, Jeffrey D Labban, Ki H Chon, Barbara E Shykoff, Jay Harran, John P Florian
BACKGROUND: The influence of prolonged and repeated water immersions on heart rate variability (HRV) and complexity was examined in 10 U.S. Navy divers who completed six-hour resting dives on five consecutive days. Pre-dive and during-dive measures were recorded daily. METHODS: Dependent variables of interest were average heart rate (HR), time-domain measures of HRV [root mean square of successive differences of the normal RR (NN) interval (RMSSD), standard deviation of the NN interval (SDNN)], frequency-domain measures of HRV [low-frequency power spectral density (psd) (LFpsd), low-frequency normalized (LFnu), high-frequency psd (HFpsd), high-frequency normalized (HFnu), low-frequency/ high-frequency ratio (LF/HF)], and non-linear dynamics of HRV [approximate entropy (ApEn)]...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29278871/the-effect-of-surface-neuromuscular-electrical-stimulation-on-patients-with-post-stroke-dysphagia
#15
Pingping Meng, Shuchao Zhang, Qiang Wang, Peipei Wang, Chao Han, Jinghui Gao, Shouwei Yue
OBJECTIVE: To assess whether the clinical efficacy of a therapeutic protocol using surface neuromuscular electrical stimulation (sNMES) on patients with post-stroke dysphagia (PSD) is superior to that without sNMES, and whether swallowing functional outcome is different with regards to different electrode placement on patients' skin of neck. METHODS: Thirty patients with PSD were randomly allocated into treatment group A (TGA), treatment group B (TGB) and control group according to a random number table...
December 15, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29277119/brain-derived-neurotropic-factor-bdnf-heterozygous-mice-are-more-susceptible-to-synaptic-protein-loss-in-cerebral-cortex-during-high-fat-diet
#16
İsmail Abidin, Selcen Aydin-Abidin, Akin Bodur, İmran İnce, Ahmet Alver
In this study we aimed to investigate whether reduced BDNF levels aggravate the susceptibility of the brain to hazardous effects of high fat diet. For this purpose, we fed BDNF heterozygous mice and wild type littermates with normal and high fat diet for 16 weeks. Concentrations of two synaptic proteins (SNAP-25 and PSD-95) and oxidative stress parameters (MDA, SOD, CAT) were evaluated in the cortex after diet period. Interestingly, body weights of BDNF heterozygous groups fed with control diet were higher than their littermates and heterozygous mice fed with HFD were the heaviest in all experimental groups...
December 25, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29274021/clinical-characteristics-and-ophthalmologic-findings-of-pituitary-adenoma-in-korean-patients
#17
Tae Gi Kim, Kyung Hyun Jin, Jaheon Kang
PURPOSE: To investigate the clinical characteristics of and ophthalmic findings in Korean patients diagnosed with a pituitary adenoma. METHODS: The medical records of 534 patients diagnosed with a pituitary adenoma at Kyung Hee University Hospital between January 2007 and December 2016 were retrospectively reviewed. RESULTS: Mean patient age was 47.9 ± 16.2 years. The most common symptoms at the time of presentation were headache (26.2%) and visual disturbance (12...
December 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29259908/optic-nerve-compression-the-role-of-the-lamina-cribrosa-and-translaminar-pressure
#18
Mario R Romano, Gilda Cennamo, Maria Angelica Breve, Michela Piedepalumbo, Claudio Iovino, Nunzio Velotti, Giovanni Cennamo
AIM: To describe the morphological changes of the lamina cribrosa (LC) in patients with optic nerve compression. METHODS: Cross-sectional study. Twenty eyes with optic nerve compression, affected by Graves' ophthalmopathy (GO) were compared with 18 refractive error-matched healthy eyes. The following examinations were performed: best-corrected visual acuity (BCVA), intraocular pressure, optic nerve echography, visual field, SD-OCT including the retinal nerve fiber layer (RNFL), ganglion cell complex (GCC), and LC thickness and extent...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29259324/revisiting-medial-preoptic-area-plasticity-induced-in-male-mice-by-sexual-experience
#19
Arnaud Jean, Pauline Bonnet, Philippe Liere, Sakina Mhaouty-Kodja, Helene Hardin-Pouzet
Sexual experience in male rodents, induced by a first exposure to a receptive female, improves efficiency of following copulations. In mice, the mechanisms supporting this improvement are poorly understood. We characterized molecular modifications of the mouse hypothalamic medial preoptic area (mPOA), the main integrative structure for male sexual behaviour, after a single mating event. This paradigm induced long-lasting behavioural improvements and mPOA morphological changes, evidenced by dendritic spine maturation and an increase in the acetylated and tri-methylated forms of histone H3...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29250591/shank-proteins-differentially-regulate-synaptic-transmission
#20
Rebecca Shi, Patrick Redman, Dipanwita Ghose, Yan Liu, Xiaobai Ren, Lei J Ding, Mingna Liu, Kendrick J Jones, Weifeng Xu
Shank proteins, one of the principal scaffolds in the postsynaptic density (PSD) of the glutamatergic synapses, have been associated with autism spectrum disorders and neuropsychiatric diseases. However, it is not known whether different Shank family proteins have distinct functions in regulating synaptic transmission, and how they differ from other scaffold proteins in this aspect. Here, we investigate the role of Shanks in regulating glutamatergic synaptic transmission at rat hippocampal SC-CA1 synapses, using lentivirus-mediated knockdown and molecular replacement combined with dual whole-cell patch clamp in hippocampal slice culture...
November 2017: ENeuro
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