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https://www.readbyqxmd.com/read/28643105/differential-role-of-gabaa-receptors-and-neuroligin-2-for-perisomatic-gabaergic-synapse-formation-in-the-hippocampus
#1
Patrizia Panzanelli, Simon Früh, Jean-Marc Fritschy
Perisomatic GABAergic synapses onto hippocampal pyramidal cells arise from two populations of basket cells with different neurochemical and functional properties. The presence of the dystrophin-glycoprotein complex in their postsynaptic density (PSD) distinguishes perisomatic synapses from GABAergic synapses on dendrites and the axon-initial segment. Targeted deletion of neuroligin 2 (NL2), a transmembrane protein interacting with presynaptic neurexin, has been reported to disrupt postsynaptic clustering of GABAA receptors (GABAAR) and their anchoring protein, gephyrin, at perisomatic synapses...
June 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28639004/the-hair-in-the-sinus-sharp-ended-rootless-head-hair-fragments-can-be-found-in-large-amounts-in-pilonidal-sinus-nests
#2
Friederike Bosche, Markus M Luedi, Dominic van der Zypen, Philipp Moersdorf, Bjoern Krapohl, Dietrich Doll
PURPOSE: Hair has been identified as the causative agent of Pilonidal Sinus Disease (PSD). Stiffer, dark hair as well as hairiness has been postulated as causative factors. Astonishingly, despite the early clinical significance of this condition (Hodges in Boston Med Surg J 2:485-486, 1880), macroscopic and microscopic examinations of hair inside pilonidal sinus cavities have been scarce. The purpose of this study was to study the morphological aspects of the hair found in PSD in order to determine the origin of the hair...
June 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28633838/sonochemically-preparation-and-characterization-of-bimetallic-ni-co-al2o3-zro2-nanocatalyst-effects-of-ultrasound-irradiation-time-and-power-on-catalytic-properties-and-activity-in-dry-reforming-of-ch4
#3
Salar Mahboob, Mohammad Haghighi, Farhad Rahmani
The catalytic performance of nanostructured Ni-Co/Al2O3-ZrO2 catalysts, prepared by ultrasound-assisted impregnation method was examined in the dry reforming of methane. The effect of irradiation power and irradiation time have been studied by changing time (0, 20, 80min) and power of the sonication (30, 60, 90W) during the synthesis which resulted in different physiochemical properties of the nanocatalyst. The nanocatalysts were characterized by XRD, FESEM, PSD, EDX, TEM, TPR-H2, BET, FTIR and TG analyses...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28630404/activation-of-d1r-pka-mtor-signaling-cascade-in-medial-prefrontal-cortex-underlying-the-antidepressant-effects-of-l-spd
#4
Bing Zhang, Fei Guo, Yuqin Ma, Yingcai Song, Rong Lin, Fu-Yi Shen, Guo-Zhang Jin, Yang Li, Zhi-Qiang Liu
Major depressive disorder (MDD) is a common neuropsychiatric disorder characterized by diverse symptoms. Although several antidepressants can influence dopamine system in the medial prefrontal cortex (mPFC), but the role of D1R or D2R subtypes of dopamine receptor during anti-depression process is still vague in PFC region. To address this question, we investigate the antidepressant effect of levo-stepholidine (l-SPD), an antipsychotic medication with unique pharmacological profile of D1R agonism and D2R antagonism, and clarified its molecular mechanisms in the mPFC...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28623819/the-texture-structure-and-nutrient-availability-of-artificial-soil-on-cut-slopes-restored-with-osss-influence-of-restoration-time
#5
Zhiyu Huang, Jiao Chen, Xiaoyan Ai, Ruirui Li, Yingwei Ai, Wei Li
Outside soil spray seeding (OSSS) is widely used to restore cut slopes in southwest of China, and artificial soil is often sprayed onto cut slopes to establish a soil layer for revegetation. The stability of artificial soil layer and its supply of water and nutrients for plants is crucial for successful restoration. To evaluate the long-term effectiveness of OSSS, the texture, structure and nutrient availability of artificial soil were studied, various soil samples were obtained from three cut slopes with different restoration time (restored with OSSS in 1996, 2003 and 2007 respectively) and one natural developed slope (NS)...
June 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28623607/presenilin-1-targeted-morpholino-induces-cognitive-deficits-increased-brain-a%C3%AE-1-42-and-decreased-synaptic-marker-psd-95-in-zebrafish-larvae
#6
Laura Roesler Nery, Natalia Eltz Silva, Raphaela Fonseca, Monica Ryff Moreira Vianna
Presenilins are transmembrane proteases required for the proteolytic cleavage of Notch and also act as the catalytic core of the γ-secretase complex, which is responsible for the final cleavage of the amyloid precursor protein into Amyloid-β (Aβ) peptides of varying lengths. Presenilin-1 gene (psen1) mutations are the main cause of early-onset autosomal-dominant Familial Alzheimer Disease. Elucidating the roles of Presenilin-1 and other hallmark proteins involved in Alzheimer's disease is crucial for understanding the disease etiology and underlying molecular mechanisms...
June 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28617528/influence-of-ablation-therapy-on-the-quality-of-life-in-children-with-supraventricular-tachycardia
#7
E Szafran, A Baszko, A Bukowska-Posadzy, A Łaźniak, T Moszura, A Siwińska, J Walkowiak, W Bobkowski
OBJECTIVE: Numerous restrictions, which are imposed on children with arrhythmia, influence their quality of life (QoL) and may have a negative impact on their further development. Ablation is a highly successful treatment leaving patients free from arrhythmia and other related limitations. There are very few studies evaluating the influence of ablation on the QoL in children with arrhythmia, based on small groups of patients. The aim of this study was to evaluate the impact of ablation on the QoL in children with supraventricular tachycardia (SVT)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28612976/lithium-ameliorates-sleep-deprivation-induced-mania-like-behavior-hypothalamic-pituitary-adrenal-hpa-axis-alterations-oxidative-stress-and-elevations-of-cytokine-concentrations-in-the-brain-and-serum-of-mice
#8
Samira S Valvassori, Wilson R Resende, Gustavo Dal-Pont, Heron Sangaletti-Pereira, Fernanda F Gava, Bruna R Peterle, Roger B Varela, Felipe Dal-Pizzol, João Quevedo
OBJECTIVES: The goal of the present study was to investigate the effects of lithium administration on behavior, oxidative stress parameters and cytokine levels in the periphery and brain of mice subjected to an animal model of mania induced by paradoxical sleep deprivation (PSD). METHODS: Male C57 mice were treated with saline or lithium for 7 days. The sleep deprivation protocol started on the 5th day during for the last 36 hours of the treatment period. Immediately after the sleep deprivation protocol, animals locomotor activity was evaluated and serum and brain samples was extracted to evaluation of corticosterone and adrenocorticotropic hormone circulating levels, oxidative stress parameters and citokynes levels...
June 14, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28610693/assessment-of-peak-skin-dose-in-interventional-cardiology-a-comparison-between-gafchromic-film-and-dosimetric-software-em-dose
#9
J Greffier, C Van Ngoc Ty, G Bonniaud, G Moliner, B Ledermann, L Schmutz, L Cornillet, G Cayla, J P Beregi, F Pereira
OBJECTIVE: To compare the use of a dose mapping software to Gafchromic film measurement for a simplified peak skin dose (PSD) estimation in interventional cardiology procedure. METHODS: The study was conducted on a total of 40 cardiac procedures (20 complex coronary angioplasty of chronic total occlusion (CTO) and 20 coronary angiography and coronary angioplasty (CA-PTCA)) conducted between January 2014 to December 2015. PSD measurement (PSDFilm) was obtained by placing XR-RV3 Gafchromic under the patient's back for each procedure...
June 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28604739/autism-like-behaviours-and-enhanced-memory-formation-and-synaptic-plasticity-in-lrfn2-salm1-deficient-mice
#10
Naoko Morimura, Hiroki Yasuda, Kazuhiko Yamaguchi, Kei-Ichi Katayama, Minoru Hatayama, Naoko H Tomioka, Maya Odagawa, Akiko Kamiya, Yoshimi Iwayama, Motoko Maekawa, Kazuhiko Nakamura, Hideo Matsuzaki, Masatsugu Tsujii, Kazuyuki Yamada, Takeo Yoshikawa, Jun Aruga
Lrfn2/SALM1 is a PSD-95-interacting synapse adhesion molecule, and human LRFN2 is associated with learning disabilities. However its role in higher brain function and underlying mechanisms remain unknown. Here, we show that Lrfn2 knockout mice exhibit autism-like behavioural abnormalities, including social withdrawal, decreased vocal communications, increased stereotyped activities and prepulse inhibition deficits, together with enhanced learning and memory. In the hippocampus, the levels of synaptic PSD-95 and GluA1 are decreased...
June 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28602762/different-patterns-of-changes-between-actin-dynamics-and-synaptic-density-in-the-rat-s-primary-visual-cortex-during-a-special-period-of-visual-development
#11
Mei-Qing Chen, Ai-Ling Bi, Yue-Ying Zhang, Qin Yan, Yuan-Yuan Sun, Xiu-Yan Zhang, Xian-Zhen Ma, Hong-Sheng Bi
In our previous study, we found that the normalized levels of the synaptosomal filament actin (F-actin) to monomeric global actin (G-actin) ratio in the primary visual cortex (V1) of rats was significantly lower on postnatal day (P) 45 compared with P30, however, the synaptic density in the monocular area of primary visual cortex (V1M) maintained a stable high level from P30 to P45. The mechanisms underlying the different patterned of change in synaptic density and actin rearrangements from P30 to P45 are unclear...
June 8, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28600933/malondialdehyde-a-novel-predictive-biomarker-for-post-stroke-depression
#12
Zhihua Liu, Zhuoying Zhu, Jiyun Zhao, Wenwei Ren, Yan Cai, Qiongzhang Wang, Xiaoqian Luan, Kai Zhao, Jincai He
BACKGROUND: There is evidence that stroke is accompanied by oxidative stress. However, the links between oxidative stress and depression in stroke patients are poorly understood. This study examines whether post-stroke depression (PSD) is associated with oxidative stress. METHODS: Overall, 216 acute stroke patients were consecutively recruited and followed up for 1 month. Blood specimens were collected within 24h after admission and measured for the following oxidative stress biomarkers: malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX)...
May 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28593514/influence-of-formulation-factors-on-the-aerosol-performance-of-suspension-and-solution-metered-dose-inhalers-a-systematic-approach
#13
Poonam Sheth, Dennis Sandell, Denise S Conti, Jay T Holt, Anthony J Hickey, Bhawana Saluja
Metered dose inhalers (MDIs) are complex drug-device combination products widely used to treat pulmonary disorders. The efficacy, driven by aerosol performance of the products, depends on a multitude of factors including, but not limited to, the physicochemical properties of drug and nature and amount of excipient(s). Under the quality by design (QbD) paradigm, systematic investigations are necessary to understand how changes in critical quality attributes (CQAs) of formulation, device, and manufacturing process influence key product performance parameters, such as delivered dose (DD) and fine particle dose (FPD)...
June 7, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28593193/differential-expression-and-cell-type-specificity-of-perineuronal-nets-in-hippocampus-medial-entorhinal-cortex-and-visual-cortex-examined-in-the-rat-and-mouse
#14
Kristian Kinden Lensjø, Ane Charlotte Christensen, Simen Tennøe, Marianne Fyhn, Torkel Hafting
Perineuronal nets (PNNs) are specialized extracellular matrix (ECM) structures that condense around the soma and proximal dendrites of subpopulations of neurons. Emerging evidence suggests that they are involved in regulating brain plasticity. However, the expression of PNNs varies between and within brain areas. A lack of quantitative studies describing the distribution and cell-specificity of PNNs makes it difficult to reveal the functional roles of PNNs. In the current study, we examine the distribution of PNNs and the identity of PNN-enwrapped neurons in three brain areas with different cognitive functions: the dorsal hippocampus, medial entorhinal cortex (mEC) and primary visual cortex (V1)...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28590114/analysis-of-nano-precipitates-in-a-na-doped-pbte-srte-thermoelectric-material-with-a-high-figure-of-merit
#15
Yoon-Jun Kim, Li-Dong Zhao, Mercouri G Kanatzidis, David N Seidman
The dimensionless figure of merit, ZT, of bulk thermoelectric materials depends mainly on the transport properties of charge carriers and heat carrying phonons. PbTe-4 mol.% SrTe doped with 2 mol.% Na (Pb0.94Na0.02Sr0.04Te) is a nanostructured material system, which exhibits a ZT higher than 2. A precipitate size distribution (PSD) of SrTe precipitates is believed to play a key role. This raises the question of whether its performance is limited by precipitate coarsening (Ostwald ripening) at elevated temperatures...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28585476/harmonic-analysis-of-peripheral-pulse-for-screening-subjects-at-high-risk-of-diabetes
#16
G D Jindal, Rajesh Kumar Jain, Sushma N Bhat, Jyoti A Pande, Manasi S Sawant, Sameer K Jindal, Alaka K Deshpande
Power spectral density (PSD) of peripheral pulses in human has been investigated in the past for its clinical applications. Continuing the efforts, data acquired using Peripheral Pulse Analyser in research projects sponsored by Board of Research in Nuclear Sciences in 207 control subjects, 18 descendants of diabetic patients and 22 patients with systemic hypertension have been subjected to PSD analysis for its study of harmonics. Application software, named Pulse Harmonic Analyser specifically developed for this work, selected 131,072 samples from each data file, obtained PSD, derived 52 PHA parameters and saved them in an Excel sheet...
June 6, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28583576/administration-of-huperzine-a-exerts-antidepressant-like-activity-in-a-rat-model-of-post-stroke-depression
#17
Yuan Du, Haiyue Liang, Leiming Zhang, Fenghua Fu
Post-stroke depression (PSD) is the most common mood disorder following a stroke, and is also the main factor limiting recovery and rehabilitation in stroke patients. The present study was aimed to investigate whether Huperzine A (HupA) has antidepressant-like activity in a rat model of PSD, which was developed by middle cerebral artery occlusion followed by an 18-day chronic unpredictable mild stress in conjunction with isolation rearing. The sucrose preference and forced swim tests were used to assess depression-like behavior...
July 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28581714/magnetic-properties-as-a-proxy-for-predicting-fine-particle-bound-heavy-metals-in-a-support-vector-machine-approach
#18
Huiming Li, Jinhua Wang, Qin'geng Wang, Chunhui Tian, Xin Qian, Xiang'zi Leng
The development of a reasonable statistical method of predicting the concentrations of fine-particle-bound heavy metals remains challenging. In this study, daily PM2.5 samples were collected within four different seasons from a Chinese mega-city. The annual average PM2.5 concentrations determined in industrial, city center, and suburban areas were 90, 81, and 85 μg m(-3), respectively. Environmental magnetic measurements, including magnetic susceptibility, anhysteretic remanent magnetization, isothermal remanent magnetization, hysteresis loops, and thermomagnetism, indicated that the main magnetic mineral of PM2...
June 5, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28577432/psychophysical-assessment-of-koniocellular-pathway-in-patients-with-schizophrenia-versus-healthy-controls
#19
Ozgur Bulent Timucin, Elif Aktan Mutlu, Damla Timucin, Mehmet Emin Aslanci, Isil Isikligil, Mehmet Fatih Karadag, Esra Kizildag Ozbay
This study was designed to perform psychophysical assessment of koniocellular pathway in patients with schizophrenia versus healthy controls. A total of 26 patients diagnosed with schizophrenia and 15 healthy controls were included. Snellen Visual Acuity Chart scores and Short Wavelength Automated Perimetry (SWAP) visual field testing including global visual field indices [mean deviation (MD), pattern standard deviation (PSD), test time (min)], reliability parameters [false negative responses (%), false positive responses (%) and fixed losses (%)] and average threshold sensitivity [central (parafovea), peripheral area, and four quadrants] were recorded in both groups...
May 26, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28577431/supramolecular-organization-of-nmda-receptors-and-the-postsynaptic-density
#20
REVIEW
René Aw Frank, Seth Gn Grant
The postsynaptic density (PSD) of all vertebrate species share a highly complex proteome with ∼1000 conserved proteins that function as sophisticated molecular computational devices. Here, we review recent studies showing that this complexity can be understood in terms of the supramolecular organization of proteins, which self-assemble within a hierarchy of different length scales, including complexes, supercomplexes and nanodomains. We highlight how genetic and biochemical approaches in mice are being used to uncover the native molecular architecture of the synapse, revealing hitherto unknown molecular structures, including highly selective mechanisms for specifying the assembly of NMDAR-MAGUK supercomplexes...
May 31, 2017: Current Opinion in Neurobiology
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