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https://www.readbyqxmd.com/read/29667630/-the-principal-and-auxiliary-immunohistochemical-markers-of-intravital-mechanical-strangulation-asphyxia
#1
D V Bogomolov, V A Fetisov, O P Denisova, Yu V Zbrueva, G G Semenov
The objective of the present study was the evaluation of the auxiliary methods for the diagnostics of the intravital formation of the constriction marks; the secondary objective was to determine the pace at which the death and asphyxia occur. MATERIAL AND METHODS: The materials on which the study was based included 17 cases of mechanical strangulation asphyxia involving 13 men and 4 women at the age from 8 to 28 years. All cases of hanging were associated with different blood alcohol levels...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667573/molecular-epidemiology-of-extraintestinal-pathogenic-escherichia-coli
#2
James R Johnson, Thomas A Russo
Extraintestinal pathogenic Escherichia coli (ExPEC) are important pathogens in humans and certain animals. Molecular epidemiological analyses of ExPEC are based on structured observations of E. coli strains as they occur in the wild. By assessing real-world phenomena as they occur in authentic contexts and hosts, they provide an important complement to experimental assessment. Fundamental to the success of molecular epidemiological studies are the careful selection of subjects and the use of appropriate typing methods and statistical analysis...
April 2018: EcoSal Plus
https://www.readbyqxmd.com/read/29667537/parasympathetic-activity-delayed-after-self-paced-exercise
#3
Lucas Rosiello Trojbicz, Mayara Vieira Damasceno, Leonardo Alves Pasqua, Arthur Fernandes Gáspari, Adriano Eduardo Lima-Silva, Rômulo Bertuzzi
The main purpose of this study was to compare the effect of the constant load and self-paced exercise with similar total work on autonomic control after endurance exercise. Ten physically active men were submitted to (i) a maximal incremental exercise test, (ii) a 4-km cycling time trial (4-km TT), and (iii) a constant workload test with identical total external work performed at 4-km TT. Gas exchange was measured throughout the tests, while blood lactate, heart rate, and heart rate variability (HRV) were measured during the passive recovery...
April 18, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29666811/immune-checkpoint-pathways-in-non-small-cell-lung-cancer
#4
REVIEW
Young Kwang Chae, Ayush Arya, Wade Iams, Marcello Cruz, Nisha Mohindra, Victoria Villaflor, Francis J Giles
Immunotherapy has evolved at a phenomenal pace in cancer therapeutics. This has primarily been fueled by the much perceived necessity to procure an alternative to current standard of care chemotherapy agents, owing to several concerns such as treatment-related toxicity and poor long-term survival associated with the same. The knowledge of various mechanisms involved in regulation of immune response to cancer cells has served a fundamental role in identifying key molecules through which immune cell activity may be modulated...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666796/plc%C3%AE-induced-ca-2-oscillations-in-mouse-eggs-involve-a-positive-feedback-cycle-of-ca-2-induced-insp-3-formation-from-cytoplasmic-pip-2
#5
Jessica R Sanders, Bethany Ashley, Anna Moon, Thomas E Woolley, Karl Swann
Egg activation at fertilization in mammalian eggs is caused by a series of transient increases in the cytosolic free Ca2+ concentration, referred to as Ca2+ oscillations. It is widely accepted that these Ca2+ oscillations are initiated by a sperm derived phospholipase C isoform, PLCζ that hydrolyses its substrate PIP2 to produce the Ca2+ releasing messenger InsP3 . However, it is not clear whether PLCζ induced InsP3 formation is periodic or monotonic, and whether the PIP2 source for generating InsP3 from PLCζ is in the plasma membrane or the cytoplasm...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29666762/coccolith-arrangement-follows-eulerian-mathematics-in-the-coccolithophore-emiliania-huxleyi
#6
Kai Xu, David Hutchins, Kunshan Gao
Background: The globally abundant coccolithophore, Emiliania huxleyi , plays an important ecological role in oceanic carbon biogeochemistry by forming a cellular covering of plate-like CaCO3 crystals (coccoliths) and fixing CO2 . It is unknown how the cells arrange different-sized coccoliths to maintain full coverage, as the cell surface area of the cell changes during daily cycle. Methods: We used Euler's polyhedron formula and CaGe simulation software, validated with the geometries of coccoliths, to analyze and simulate the coccolith topology of the coccosphere and to explore the arrangement mechanisms...
2018: PeerJ
https://www.readbyqxmd.com/read/29666590/examining-procrastination-across-multiple-goal-stages-a-longitudinal-study-of-temporal-motivation-theory
#7
Piers Steel, Frode Svartdal, Tomas Thundiyil, Thomas Brothen
Procrastination is among the most common of motivational failures, putting off despite expecting to be worse off. We examine this dynamic phenomenon in a detailed and realistic longitudinal design (Study 1) as well as in a large correlational data set ( N = 7400; Study 2). The results are largely consistent with temporal motivation theory. People's pacing style reflects a hyperbolic curve, with the steepness of the curve predicted by self-reported procrastination. Procrastination is related to intention-action gaps, but not intentions...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29666458/in-vivo-turnover-frequency-of-the-cyanobacterial-nife-hydrogenase-during-photohydrogen-production-outperforms-in-vitro-systems
#8
Kirstin Gutekunst, Dörte Hoffmann, Ulrike Westernströer, Rüdiger Schulz, Dieter Garbe-Schönberg, Jens Appel
Cyanobacteria provide all components for sunlight driven biohydrogen production. Their bidirectional NiFe-hydrogenase is resistant against low levels of oxygen with a preference for hydrogen evolution. However, until now it was unclear if its catalytic efficiency can keep pace with the photosynthetic electron transfer rate. We identified NikKLMQO (sll0381-sll0385) as a nickel transporter, which is required for hydrogen production. ICP-MS measurements were used to quantify hydrogenase molecules per cell. We found 400 to 2000 hydrogenase molecules per cell depending on the conditions...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666358/revisiting-atrioventricular-nodal-ablation-and-cardiac-pacing-of-atrial-fibrillation-in-a-patient-with-dextrocardia
#9
Munish Sharma, Ritesh Neupane, Koroush Khalighi
BACKGROUND Poorly controlled ventricular rate associated with atrial fibrillation (AF) leads to tachycardia-induced left ventricular dysfunction. Atrioventricular (AV) nodal ablation and cardiac pacing is the standard of care in refractory congestive heart failure (CHF) due to AF with moderate to rapid ventricular response that failed conventional medical therapy. If the patient is not a candidate for AF ablation with pulmonary vein isolation and elimination of AF foci, this is an effective approach, but it does have some challenges when done in a patient with dextrocardia and situs inversus...
April 18, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29664309/expeditious-and-chemoselective-synthesis-of-%C3%AE-aryl-and-%C3%AE-alkyl-selenomethylketones-via-homologation-chemistry
#10
Raffaele Senatore, Laura Castoldi, Laura Ielo, Wolfgang Holzer, Vittorio Pace
Diselenoacetals, previously considered byproducts in homologation tactics en route to α-selenoketones, are herein found to be excellent starting materials for this purpose. The easy selenium/lithium exchange they undergo affords seleno carbanions which are smoothly added to Weinreb amides to chemoselectively prepare α-aryl- and α-alkyl seleno methylketones through a single chemical operation. No racemization events are observed in the presence of optically pure starting materials.
April 17, 2018: Organic Letters
https://www.readbyqxmd.com/read/29663890/methodologies-related-to-computational-models-in-view-of-developing-anti-alzheimer-drugs-an-overview
#11
Kirtee Baheti, Mayura Ajay Kale
BACKGROUND: Since last two decades, there has been more focus on the development strategies related to Anti-Alzheimer's drug research. This may be attributed to the fact that most of the Alzheimer's cases are still mostly unknown except for a few cases, where genetic differences have been identified. With the progress of the disease, the symptoms involve intellectual deterioration, memory impairment, abnormal personality and behavioural patterns, confusion, aggression, mood swings, irritability Current therapies available for this disease give only symptomatic relief and do not focus on manipulations of biololecular processes...
April 17, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29663283/eeg-artifact-versus-subclinical-status-epilepticus-in-a-patient-following-cardiac-arrest
#12
Jean E Cibula, Daniel S Demos, Brenda G Fahy
BACKGROUND: A challenge in ICU EEG interpretation is identifying subclinical status epilepticus versus patterns on the ictal-interictal continuum versus other repetitive patterns. In the electrically noisy intensive care unit, identifying and eliminating interference and artifact allow accurate diagnoses from the EEG, avoiding unnecessary treatment or sedation. METHODS: We present a case during Impella (Abiomed Inc, Danvers, MA) continuous flow left ventricular assist device use where the EEG artifact was initially misinterpreted as seizure by the resident and treated as status epilepticus because of the "focal" sharply contoured repetitive pattern...
April 16, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29662986/discovery-and-characterization-of-natural-products-that-act-as-pheromones-in-fish
#13
REVIEW
Ke Li, Tyler J Buchinger, Weiming Li
Covering: up to 2018Fish use a diverse collection of molecules to communicate with conspecifics. Since Karlson and Lüscher termed these molecules 'pheromones', chemists and biologists have joined efforts to characterize their structures and functions. In particular, the understanding of insect pheromones developed at a rapid pace, set, in part, by the use of bioassay-guided fractionation and natural product chemistry. Research on vertebrate pheromones, however, has progressed more slowly. Initially, biologists characterized fish pheromones by screening commercially available compounds suspected to act as pheromones based upon their physiological function...
April 17, 2018: Natural Product Reports
https://www.readbyqxmd.com/read/29661990/effect-of-traffic-noise-and-relaxations-sounds-on-pedestrian-walking-speed
#14
Marek Franěk, Lukáš Režný, Denis Šefara, Jiří Cabal
Exposure to noise in everyday urban life is considered to be an environmental stressor. A specific outcome of reactions to environmental stress is a fast pace of life that also includes a faster pedestrian walking speed. The present study examined the effect of listening to annoying acoustical stimuli (traffic noise) compared with relaxation sounds (forest birdsong) on walking speed in a real outdoor urban environment. The participants ( N = 83) walked along an urban route of 1.8 km. They listened to either traffic noise or forest birdsong, or they walked without listening to any acoustical stimuli in the control condition...
April 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29661686/utilization-of-bia-derived-bone-mineral-estimates-exerts-minimal-impact-on-body-fat-estimates-via-multicompartment-models-in-physically-active-adults
#15
Brett S Nickerson, Grant M Tinsley
The purpose of this study was to compare body fat estimates and fat-free mass (FFM) characteristics produced by multicompartment models when utilizing either dual energy X-ray absorptiometry (DXA) or single-frequency bioelectrical impedance analysis (SF-BIA) for bone mineral content (BMC) in a sample of physically active adults. Body fat percentage (BF%) was estimated with 5-compartment (5C), 4-compartment (4C), 3-compartment (3C), and 2-compartment (2C) models, and DXA. The 5C-Wang with DXA for BMC (i.e., 5C-WangDXA ) was the criterion...
March 21, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29661150/a-moderate-500-m-treadmill-walk-for-estimating-peak-oxygen-uptake-in-men-with-nyha-class-i-ii-heart-failure-and-reduced-left-ventricular-ejection-fraction
#16
Gianni Mazzoni, Biagio Sassone, Giovanni Pasanisi, Jonathan Myers, Simona Mandini, Stefano Volpato, Francesco Conconi, Giorgio Chiaranda, Giovanni Grazzi
BACKGROUND: Maximal cardiopulmonary exercise testing (CPX) is the gold-standard for cardiorespiratory fitness assessment in chronic heart failure (CHF) patients. However, high costs, required medical supervision, and safety concerns make maximal exercise testing impractical for evaluating mobility-impaired adults. Thus, several submaximal walking protocols have been developed and currently used to estimate peak oxygen consumption (VO2 peak) in CHF patients. However, these tests have to be performed at close to maximum exercise intensity...
April 16, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29660948/the-cardiac-autonomic-nervous-system-response-to-different-daily-demands-among-patients-at-the-sub-acute-phase-post-ischemic-stroke-and-healthy-controls
#17
Noa Raphaely Beer, Nachum Soroker, Nathan M Bornstein, Michal Katz Leurer
BACKGROUND: Autonomic disturbances are a common phenomenon in patients' post-stroke, characterized by hypo function of the para-sympathetic and/or overactive sympathetic system. The impact of autonomic disturbances on physical therapy tasks during the rehabilitation period has not yet been assessed. OBJECTIVE: To describe the response of the cardiac autonomic nervous system during different tasks, among patients and age-matched healthy controls. METHODS: 19 patients in the subacute phase post first-ever ischemic stroke, and 16 controls...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29660447/the-usefulness-of-ventricular-pacing-during-atrial-fibrillation-ablation-in-a-persistent-left-superior-vena-cava-a-case-report
#18
Sen Matsumoto, Yasuharu Matsunaga-Lee, Nobutaka Masunaga, Yuzuru Takano
A 69-year-old woman with palpitations was referred to our hospital for a second session of atrial fibrillation (AF) catheter ablation. She had a history of AF ablation including pulmonary vein (PV) isolation and persistent left superior vena cava (PLSVC) isolation. Electrophysiologic studies showed the veno-atrial connections that had recovered. After PV isolation was performed, AF was induced by atrial premature contraction (APC) from the PLSVC, and AF storm occurred. During PLSVC isolation, AF was not induced by APC from the PLSVC...
April 13, 2018: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29659695/deepsimulator-a-deep-simulator-for-nanopore-sequencing
#19
Yu Li, Renmin Han, Chongwei Bi, Mo Li, Sheng Wang, Xin Gao
Motivation: Oxford Nanopore sequencing is a rapidly developed sequencing technology in recent years. To keep pace with the explosion of the downstream data analytical tools, a versatile Nanopore sequencing simulator is needed to complement the experimental data as well as to benchmark those newly developed tools. However, all the currently available simulators are based on simple statistics of the produced reads, which have difficulty in capturing the complex nature of the Nanopore sequencing procedure, the main task of which is the generation of raw electrical current signals...
April 6, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29659566/biocuration-distilling-data-into-knowledge
#20
(no author information available yet)
Data, including information generated from them by processing and analysis, are an asset with measurable value. The assets that biological research funding produces are the data generated, the information derived from these data, and, ultimately, the discoveries and knowledge these lead to. From the time when Henry Oldenburg published the first scientific journal in 1665 (Proceedings of the Royal Society) to the founding of the United States National Library of Medicine in 1879 to the present, there has been a sustained drive to improve how researchers can record and discover what is known...
April 16, 2018: PLoS Biology
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