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https://www.readbyqxmd.com/read/29913089/deficits-in-saccades-and-smooth-pursuit-eye-movements-in-adults-with-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#1
Revathy Mani, Lisa Asper, Sieu K Khuu
PURPOSE: To conduct a review of literature and quantify the effect that traumatic brain injury (TBI) has on oculomotor functions (OM). METHODS: A systematic review and meta-analysis was conducted from papers that objectively measured saccades and smooth-pursuit eye movements in mild and severe TBI. RESULTS: The overall impact of TBI on OM functions was moderate and significant with an effect size of 0.42 from 181 OM case-control comparisons...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29912859/energetics-of-swimming-with-hand-paddles-of-different-surface-areas
#2
George H Crocker, Joseph F Moon, Jeff A Nessler, Sean C Newcomer
Crocker, GH, Moon, JF, Nessler, JA, and Newcomer, SC. Energetics of swimming with hand paddles of different surface areas. J Strength Cond Res XX(X): 000-000, 2018-Hand paddles are one of the most common training aids used by the competitive swimmer, yet little is known regarding how hand paddle surface area affects the metabolic cost of transport (COT) while swimming. The purpose of this study was to determine how altering hand paddle size affects energy use during submaximal, front-crawl (i.e., freestyle) swimming...
June 15, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29912794/intraindividual-and-interindividual-variability-of-olanzapine-trough-concentrations-in-patients-treated-with-the-long-acting-injectable-formulation
#3
Sara Baldelli, Massimo C Mauri, Chiara Di Pace, Silvia Paletta, Alessandra Reggiori, Chiara Rovera, Emilio Clementi, Dario Cattaneo
BACKGROUND: A long-acting injectable (LAI) formulation of olanzapine has been developed as an alternative to oral regimens. A therapeutic range of 20 to 80 ng/mL for oral olanzapine trough concentrations has been proposed. Here, we sought to investigate the intraindividual and interindividual variability of olanzapine concentrations with time in patients on maintenance therapy with the LAI formulation carried out in the routine clinical practice. METHODS: To address this issue, we carried out a retrospective analysis of therapeutic drug monitoring of olanzapine concentrations in 21 schizophrenic patients on maintenance LAI olanzapine...
June 14, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912448/nuclear-stress-testing-referrals-time-for-a-novel-radiation-sparing-approach
#4
Steven C Romero, Joshua P Dettmer
Background: A Science Advisory from the American Heart Association implores clinicians to always consider equivalent tests which do not use ionizing radiation. Intersocietal guidelines describe only two scenarios where a nuclear stress test is the only option for non-invasive evaluation: left bundle branch block (LBBB) and ventricular-paced rhythm; otherwise, treadmill EKG and stress echocardiography are feasible. This study sought to measure our compliance with appropriate use criteria,6 and then to apply our own Novel Radiation Sparing Approach (NRSA) to measure what percentage could have been evaluated without radiation...
April 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29912139/transesophageal-echocardiography-guided-epicardial-left-ventricular-lead-placement-by-video-assisted-thoracoscopic-surgery-in-nonresponders-to-biventricular-pacing-and-previous-chest-surgery
#5
Carsten Schroeder, Jane M Chung, Judith A Mackall, Ivan T Cakulev, Aaron Patel, Sunny J Patel, Brian D Hoit, Jayakumar Sahadevan
OBJECTIVE: The aim of the study was to study the feasibility, safety, and efficacy of transesophageal echocardiography-guided intraoperative left ventricular lead placement via a video-assisted thoracoscopic surgery approach in patients with failed conventional biventricular pacing. METHODS: Twelve patients who could not have the left ventricular lead placed conventionally underwent epicardial left ventricular lead placement by video-assisted thoracoscopic surgery...
June 14, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29912081/combined-effects-of-self-myofascial-release-and-dynamic-stretching-on-range-of-motion-jump-sprint-and-agility-performance
#6
Erick D Richman, Brian M Tyo, Clayton R Nicks
Richman, ED, Tyo, BM, and Nicks, CR. Combined effects of self-myofascial release and dynamic stretching on range of motion, jump, sprint, and agility performance. J Strength Cond Res XX(X): 000-000, 2018-Massage has been used as both a pre- and post-exercise modality with purported benefits to flexibility and athletic performance. This study was designed to determine the effect of a 6-minute protocol of self massage known as self-myofascial release (SMR) using a foam rolling device in conjunction with a general warm-up and sport-specific dynamic stretching (DS) session on flexibility and explosive athletic performance in a sample of 14 female collegiate athletes...
June 14, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29912073/an-assessment-of-running-power-as-a-training-metric-for-elite-and-recreational-runners
#7
Rachel L Aubry, Geoff A Power, Jamie F Burr
Aubry, RL, Power, GA, and Burr, JF. An assessment of running power as a training metric for elite and recreational runners. J Strength Cond Res XX(X): 000-000, 2018-Power, as a testing and training metric to quantify effort, is well accepted in cycling, but is not commonly used in running to quantify effort or performance. This study sought to investigate a novel training tool, the Stryd Running Power Meter, and the applicability of running power (and its individually calculated run mechanics) to be a useful surrogate of metabolic demand (V[Combining Dot Above]O2), across different running surfaces, within different caliber runners...
June 14, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29910580/three-dimensional-echocardiography-with-left-ventricular-strain-analyses-helps-earlier-prediction-of-right-ventricular-pacing-induced-cardiomyopathy
#8
N M Sharath Babu, Sirish C Srinath, Anandaroop Lahiri, David Chase, Bobby John, John Roshan
Background and objectives: Right ventricular (RV) pacing can lead to progressive ventricular dysfunction over a certain period. This pacemaker-induced cardiomyopathy (PiCMP) may be more common than previously reported. Speckle tracking imaging is a recent development in echocardiography that can identify left ventricular (LV) dysfunction even before the LV ejection fraction (LVEF) value decreases. Three-dimensional (3D) echocardiography has made more accurate assessment of LVEF possible...
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29910412/effect-of-yang-style-tai-chi-on-gait-parameters-and-musculoskeletal-flexibility-in-healthy-chinese-older-women
#9
Liye Zou, Chaoyi Wang, Zuguo Tian, Huiru Wang, Yankai Shu
The purpose of the present study was to examine the effect of Yang-style Tai chi (TC) on gait parameters and musculoskeletal flexibility in healthy Chinese female adults. Sixty-six female adults aged >65 years were randomly assigned to either an experimental group (67.9 ± 3.2 years of age) receiving three 90-min simplified 24-form TC sessions for eight weeks, or a control group (67.4 ± 2.9 years of age) who maintained their daily lifestyles. All study participants were instructed to perform a selected pace walking for recording gait parameters (stride length, gait speed, swing cycle time, stance phase, and double support times) at both baseline and after the experiment...
July 17, 2017: Sports (Basel)
https://www.readbyqxmd.com/read/29909166/nanoparticle-plant-interaction-implications-in-energy-environment-and-agriculture
#10
REVIEW
Prabhat Kumar Rai, Vanish Kumar, SangSoo Lee, Nadeem Raza, Ki-Hyun Kim, Yong Sik Ok, Daniel C W Tsang
In the recent techno-scientific revolution, nanotechnology has gained popularity at a rapid pace in different sectors and disciplines, specifically environmental, sensing, bioenergy, and agricultural systems. Controlled, easy, economical, and safe synthesis of nanomaterials is desired for the development of new-age nanotechnology. In general, nanomaterial synthesis techniques, such as chemical synthesis, are not completely safe or environmentally friendly due to harmful chemicals used or to toxic by-products produced...
June 14, 2018: Environment International
https://www.readbyqxmd.com/read/29909085/essential-steps-in-bioprinting-from-pre-to-post-bioprinting
#11
REVIEW
Pallab Datta, Ananya Barui, Yang Wu, Veli Ozbolat, Kazim K Moncal, Ibrahim T Ozbolat
An increasing demand for directed assembly of biomaterials has inspired the development of bioprinting, which facilitates the assembling of both cellular and acellular inks into well-arranged three-dimensional (3D) structures for tissue fabrication. Although great advances have been achieved in the recent decade, there still exist issues to be addressed. Herein, a review has been systematically performed to discuss the considerations in the entire procedure of bioprinting. Though bioprinting is advancing at a rapid pace, it is seen that the whole process of obtaining tissue constructs from this technique involves multiple-stages, cutting across various technology domains...
June 14, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29908859/frailty-and-pre-frailty-in-middle-aged-and-older-adults-and-its-association-with-multimorbidity-and-mortality-a-prospective-analysis-of-493-737-uk-biobank-participants
#12
Peter Hanlon, Barbara I Nicholl, Bhautesh Dinesh Jani, Duncan Lee, Ross McQueenie, Frances S Mair
BACKGROUND: Frailty is associated with older age and multimorbidity (two or more long-term conditions); however, little is known about its prevalence or effects on mortality in younger populations. This paper aims to examine the association between frailty, multimorbidity, specific long-term conditions, and mortality in a middle-aged and older aged population. METHODS: Data were sourced from the UK Biobank. Frailty phenotype was based on five criteria (weight loss, exhaustion, grip strength, low physical activity, slow walking pace)...
June 13, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29908711/gene-editing-on-center-stage
#13
REVIEW
Rasmus O Bak, Natalia Gomez-Ospina, Matthew H Porteus
Smithies et al. (1985) and Jasin and colleagues (1994) provided proof of concept that homologous recombination (HR) could be applied to the treatment of human disease and that its efficiency could be improved by the induction of double-strand breaks (DSBs). A key advance was the discovery of engineered nucleases, such as zinc-finger nucleases (ZFNs) and transcription activator-like (TAL) effector nucleases (TALENs), that can generate site-specific DSBs. The democratization and widespread use of genome editing was enabled by the discovery of the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 nuclease system...
June 13, 2018: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29908393/an-update-on-adolescent-sleep-new-evidence-informing-the-perfect-storm-model
#14
REVIEW
Stephanie J Crowley, Amy R Wolfson, Leila Tarokh, Mary A Carskadon
The maturation of sleep regulatory systems during adolescence in combination with psychosocial and societal pressures culminate in a "Perfect Storm" of short and ill-timed sleep and the associated consequences for many youngsters. This model, first described by Carskadon in 2011, guides our current thinking of adolescent sleep behavior. Since the original description, the field has moved forward with remarkable pace, and this review aims to summarize recent progress and describe how this new work informs our understanding of sleep regulation and sleep behavior during this developmental time frame...
June 13, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29908371/the-addition-of-minute-ventilation-to-rate-responsive-pacing-improves-heart-rate-score-more-than-accelerometer-alone
#15
Mark Richards, Brian Olshansky, Arjun D Sharma, Nicholas Wold, Paul Jones, David Perschbacher, Bruce L Wilkoff
BACKGROUND: Heart Rate Score (HRSc)≥70%, a novel parameter, predicts risk of mortality in patients with implantable defibrillators and identifies patients who have survival benefit with DDDR versus DDD pacing. OBJECTIVE: DDDR pacing lowers HRSc and dual-sensor with minute ventilation (MV) and accelerometer (XL) improves HRSc more than accelerometer (XL) alone in patients requiring pacemakers (PM). METHODS: HRSc, the percent of all beats in the predominant 10 bpm bin, was calculated...
June 13, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29908289/decreased-contractility-and-altered-responses-to-inotropic-agents-in-myocytes-from-tachypacing-induced-heart-failure-canines
#16
BaoXi Gao, Yusheng Qu, Weston Sutherland, Ray W Chui, Kim Hoagland, Hugo M Vargas
Contractility measurements using primary isolated cardiac myocytes (CM) have commonly been used in understanding the physiology and pharmacology of cellular mechanics. In the majority of studies, CM from healthy animals were used, and fewer studies were performed with CM from diseased hearts. To better understand the translational value of contractility on the cellular level of a diseased animal model, myocytes were isolated from left ventricles of a tachypacing-induced heart failure (HF) canine model, and their contractility was measured by recording sarcomere shortening using an image-based IonOptix video system...
June 13, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29907652/cardiac-resynchronization-therapy-and-clinical-outcomes-in-continuous-flow-left-ventricular-assist-device-recipients
#17
Rakesh Gopinathannair, Henri Roukoz, Adarsh Bhan, Ashwin Ravichandran, Mustafa M Ahmed, Dmitry Familtsev, Geetha Bhat, Jennifer Cowger, Munazzah Abdullah, Chirag Sandesara, Rahul Dhawan, Emma J Birks, Jaimin R Trivedi, Mark S Slaughter
BACKGROUND: Many patients with heart failure continue cardiac resynchronization therapy (CRT) after continuous flow left ventricular assist device (CF-LVAD) implant. We report the first multicenter study to assess the impact of CRT on clinical outcomes in CF-LVAD patients. METHODS AND RESULTS: Analysis was performed on 488 patients (58±13 years, 81% male) with an implantable cardioverter defibrillator (ICD) (n=223) or CRT-D (n=265) who underwent CF-LVAD implantation at 5 centers from 2007 to 2015...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907155/green-leafy-vegetables-in-diets-with-a-25-1-omega-6-omega-3-fatty-acid-ratio-modify-the-erythrocyte-fatty-acid-profile-of-spontaneously-hypertensive-rats
#18
Melissa Johnson, Ralphenia D Pace, Wendell H McElhenney
BACKGROUND: In addition to the actual composition of the diet (i.e. nutrient composition, food groups), the omega-6/omega-3 fatty acid ratio has been demonstrated to influence the tissue fatty acid profile and subsequently the risk for cardiovascular and other diseases. Likewise, the consumption of green leafy vegetables (GLVs) may favorably reduce the risks associated with disease. Although an ~ 3:1 omega-6/omega-3 fatty acid ratio (ω-6/ω-3 FAR) is recommended, the typical American diet has an ~ 25:1 ω-6/ω-3 FAR...
June 15, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29904087/damage-associated-molecular-pattern-recognition-is-required-for-induction-of-retinal-neuroprotective-pathways-in-a-sex-dependent-manner
#19
Marcus J Hooper, Jiangang Wang, Robert Browning, John D Ash
Retinal degeneration is a common cause of irreversible blindness and is caused by the death of retinal light-sensitive neurons called photoreceptors. At the onset of degeneration, stressed photoreceptors cause retinal glial cells to secrete neuroprotective factors that slow the pace of degeneration. Leukemia inhibitory factor (LIF) is one such factor that is required for endogenous neuroprotection. Photoreceptors are known to release signals of cellular stress, called damage-associated molecular patterns (DAMPs) early in degeneration, and we hypothesized that receptors for DAMPs or pattern recognition receptors (PRRs) play a key role in the induction of LIF and neuroprotective stress responses in retinal glial cells...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902995/how-is-a-specialist-depression-service-effective-for-persistent-moderate-to-severe-depressive-disorder-a-qualitative-study-of-service-user-experience
#20
Louise Thomson, Marcus Barker, Catherine Kaylor-Hughes, Anne Garland, Rajini Ramana, Richard Morriss, Emily Hammond, Gail Hopkins, Sandra Simpson
BACKGROUND: A specialist depression service (SDS) offering collaborative pharmacological and cognitive behaviour therapy treatment for persistent depressive disorder showed effectiveness against depression symptoms versus usual community based multidisciplinary care in a randomised controlled trial (RCT) in specialist mental health services in England. However, there is uncertainty concerning how specialist depression services effect such change. The current study aimed to evaluate the factors which may explain the greater effectiveness of SDS compared to Treatment as Usual (TAU) by exploring the experience of the RCT participants...
June 15, 2018: BMC Psychiatry
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