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Transfusion associated NEC

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https://www.readbyqxmd.com/read/29068791/transfusion-associated-necrotizing-enterocolitis-re-evaluated-a-systematic-review-and-meta-analysis
#1
Stientje Esther Rai, Amneet Kaur Sidhu, Rohin Jayaram Krishnan
CONTEXT: Significant controversy exists surrounding the possible association between recent packed red blood cell (PRBC) transfusion and the subsequent development of necrotizing enterocolitis (NEC) in infants. Previous studies and meta-analyses reporting a statistically significant association led to a practice change to withhold enteral feeds in the peri-transfusion period in many centers in an effort to prevent NEC; however, results from more recent studies do not support the existence of an association and, thus, question the validity of this practice change...
October 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28780310/outcome-of-neonates-with-gastroschisis-at-different-gestational-ages-using-a-national-database
#2
Ruby Gupta, Erwin T Cabacungan
BACKGROUND/PURPOSE: The optimal time for delivery of neonates with a prenatal diagnosis of gastroschisis (GS) is controversial. We compared the outcomes for GS at three different gestational ages (GAs), 33-34 weeks, 35-36 weeks, and ≥ 37 weeks. METHODS: We analyze hospital discharge data of neonates with GS using the 2006, 2009 and 2012 Healthcare Cost and Utilization Project Kids' Inpatient Database (HCUPKIDS). Multivariable analysis was used to compare the association between GS outcomes and the three GAs...
July 22, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28715801/fetal-urine-production-rate-in-preterm-premature-rupture-of-membranes-is-associated-with-adverse-neonatal-outcome-a-pilot-study
#3
Tehila Avitan, Lior Drukker, Hadass Pri-Chen, Ron Rabinowitz, Nurit Algur, Michael S Schimmel, Letizia Schreiber, Tali Bdolah-Abram, Arnon Samueloff, Sorina Grisaru-Granovsky
AIM: In this study, we evaluate the associations between fetal urinary production rate (FUPR), measured by ultrasound, and adverse neonatal outcome in women with preterm premature rupture of membranes (PPROM). METHODS: We conducted a prospective pilot cohort of singleton pregnancies complicated by PPROM occurring at gestational week 24 or later managed until spontaneous labor (after 48 h of admission), chorioamnionitis, or induction by protocol at 35 + 0 weeks. FUPR was evaluated by 2D sonography at admission (corrected for gestational age)...
July 18, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28662083/report-about-term-infants-with-severe-hyperbilirubinemia-undergoing-exchange-transfusion-in-southwestern-china-during-an-11-year-period-from-2001-to-2011
#4
Canfeng Yu, Huifan Li, Qiannan Zhang, Huayun He, Xinhong Chen, Ziyu Hua
OBJECTIVES: This study was intended to explore the etiology and risk factors of severe neonatal hyperbilirubinemia and to analyze the adverse events associated with ECT (Exchange Transfusion), as well as to identify the factors related to the poor prognosis. METHODS: All of the full-term neonates who had undergone ECT for hyperbilirubinemia at Children's Hospital of Chongqing Medical University from January 2001 to December 2011 were enrolled in this study. General demographic characteristics, comorbidities, pre- and post-exchange TSB(Total Serum Bilirubin) levels, duration and frequency of ECT, and clinical outcomes were recorded and analyzed anonymously...
2017: PloS One
https://www.readbyqxmd.com/read/28643465/severe-hemolysis-after-plasma-transfusion-in-a-neonate-with-necrotizing-enterocolitis-clostridium-perfringens-infection-and-red-blood-cell-t-polyagglutination
#5
Julia Moh-Klaren, Gwellaouen Bodivit, Myriam Jugie, Philippe Chadebech, Laurent Chevret, Mostafa Mokhtari, Xavier Chamillard, Philippe Gallon, Pierre Tissières, Philippe Bierling, Rachid Djoudi, France Pirenne, Nicolas Burin-des-Roziers
BACKGROUND: Red blood cell (RBC) Thomsen-Friedenreich antigen exposure (T activation) in infants with necrotizing enterocolitis (NEC) has occasionally been associated with posttransfusional intravascular hemolysis thought to be due to anti-T antibodies in the donor plasma. STUDY DESIGN AND METHODS: We describe an infant with NEC and Clostridium perfringens infection complicated by severe hemolysis after plasma transfusion. After this case, infants with confirmed NEC were prospectively evaluated for T activation...
June 22, 2017: Transfusion
https://www.readbyqxmd.com/read/28632783/transient-effects-of-transfusion-and-feeding-advances-volumetric-and-caloric-on-necrotizing-enterocolitis-development-a-case-crossover-study
#6
Vi T Le, Mark A Klebanoff, Maria M Talavera, Jonathan L Slaughter
OBJECTIVE: To evaluate the short-term effects of feed fortification, feed volume increase, and PRBC transfusion on the odds of developing NEC. STUDY DESIGN: Case-crossover study of neonatal intensive care infants born at ≤ 32 weeks' gestation who were admitted to 5 central Ohio intensive care units from January 2012-July 2016 and developed NEC Bell Stage ≥2. Each patient served as their own control, with exposure during the 48-hour period just prior to NEC onset (hazard period) being compared to a preceding 48-hour control period, thus eliminating confounding by patient factors fixed between both intervals...
2017: PloS One
https://www.readbyqxmd.com/read/28601308/red-blood-cell-transfusion-in-premature-infants-leads-to-worse-necrotizing-enterocolitis-outcomes
#7
Kellie E Cunningham, Frances C Okolo, Robyn Baker, Kevin P Mollen, Misty Good
BACKGROUND: Necrotizing enterocolitis (NEC) is a severe intestinal disease of premature infants with high mortality. Studies suggest a causative relationship between red blood cell (RBC) transfusion and NEC; however, whether RBC transfusion leads to worse outcomes in NEC is unknown. We sought to determine whether RBC transfusion was associated with an increased risk of surgical NEC and mortality. METHODS: In this retrospective study, 115 patients were enrolled with NEC Bell's stage 2A or greater from 2010-2015...
June 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27887684/the-relationship-of-red-blood-cell-transfusion-to-intestinal-mucosal-injury-in-premature-infants
#8
Nhan Hyung, Insiyah Campwala, Danilo S Boskovic, Laurel Slater, Yayesh Asmerom, Megan S Holden, Danilyn M Angeles, Gerald Gollin
OBJECTIVE: To determine the incidence of intestinal mucosal injury before and after transfusions in premature infants. STUDY DESIGN: Urine was collected throughout the hospital stay of 62 premature infants and specimens obtained within 24h before and after transfusion were assayed for intestinal fatty acid binding protein (iFABP). A urinary iFABP:creatinine ratio (iFABPu:Cru) of 2.0pg/nmol was considered elevated. RESULT: Forty-nine infants were transfused...
July 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27866662/should-we-believe-in-transfusion-associated-enterocolitis-applying-a-grade-to-the-literature
#9
REVIEW
Susanne Hay, John A F Zupancic, Dustin D Flannery, Haresh Kirpalani, Dmitry Dukhovny
Numerous observational studies appear to demonstrate an association between packed red blood cell (pRBC) transfusions and necrotizing enterocolitis (NEC). However, the limited numbers of randomized controlled trials (RCTs) do not support a causal relationship between pRBC transfusion and NEC. We sought to determine the quality of the evidence behind transfusion-associated necrotizing enterocolitis (TANEC), and to formulate a GRADE-based recommendation regarding transfusion practices to reduce the risk of TANEC...
February 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/27543379/risk-factors-for-necrotizing-enterocolitis-in-neonates-a-retrospective-case-control-study
#10
Qi Lu, Shupeng Cheng, Min Zhou, Jialin Yu
BACKGROUND: Necrotizing enterocolitis (NEC) in neonates is devastating, and risk-factor identification is crucial. This study aimed to evaluate risk factors for NEC in different gestational age (GA) groups. METHODS: Risk factors associated with NEC were investigated using a retrospective case-control design. Patients with Bell's Stage NEC≥II were divided into three groups based on GA: I, <34 weeks; II, ≥34 weeks but <37 weeks; III, ≥37 weeks. Each case was paired with two GA- and weight-matched controls...
April 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27249797/effects-of-red-blood-cell-transfusions-on-the-risk-of-developing-complications-or-death-an-observational-study-of-a-cohort-of-very-low-birth-weight-infants
#11
Stefano Ghirardello, Elisa Dusi, Ivan Cortinovis, Stefania Villa, Monica Fumagalli, Massimo Agosti, Silvano Milani, Fabio Mosca
Background The aim of this study was to evaluate the association between red blood cell (RBC) transfusions on the risk of death, retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), and necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants. Study Design and Methods This is an observational study. Data were entered prospectively into the study database at the time of the first transfusion. Clinical characteristics, adverse events, and outcomes of the patients transfused in the first 28 days of life were compared with the population of VLBW infants not transfused during the same period...
January 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/27031053/feeding-during-blood-transfusions-and-the-association-with-necrotizing-enterocolitis
#12
Megan Doty, Christine Wade, Julie Farr, Vanessa Celleri Gomezcoello, Gregory Martin, Tala Nasr
Objective The aim of this study was to determine whether very low-birth-weight (VLBW) infants who had feedings withheld during all blood transfusions had a lower incidence of necrotizing enterocolitis (NEC) compared with infants who were fed during transfusions. Study Design A retrospective chart review over a 3-year period in a level-3 neonatal intensive care unit was conducted. A total of 108 inborn VLBW infants (weight range: 500-1,500 g) who had received a transfusion before 36 weeks were reviewed. Diagnosis of NEC (≥ Bell stage II), demographics, feeds, transfusions, outcomes, and variables associated with NEC were collected...
July 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/26995520/blood-transfusions-increased-rates-of-surgical-nec-and-lower-survival-a-propensity-score-matched-analysis
#13
Arash J Sayari, Jun Tashiro, Juan E Sola, Eduardo A Perez
PURPOSE: We sought to investigate the association between blood transfusions (BT), rates of necrotizing enterocolitis requiring surgical intervention (SNEC), and survival. METHODS: Blood transfusions in premature infants were identified in the Kids' Inpatient Database (2003-2009). Propensity score-matched analysis compared SNEC outcomes in BT vs. non-BT groups. Multivariate analyses were performed to determine independent predictors of outcome. RESULTS: Overall, 663740 cases were identified and 4...
June 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26934258/association-of-red-blood-cell-transfusion-anemia-and-necrotizing-enterocolitis-in-very-low-birth-weight-infants
#14
MULTICENTER STUDY
Ravi M Patel, Andrea Knezevic, Neeta Shenvi, Michael Hinkes, Sarah Keene, John D Roback, Kirk A Easley, Cassandra D Josephson
IMPORTANCE: Data regarding the contribution of red blood cell (RBC) transfusion and anemia to necrotizing enterocolitis (NEC) are conflicting. These associations have not been prospectively evaluated, accounting for repeated, time-varying exposures. OBJECTIVE: To determine the relationship between RBC transfusion, severe anemia, and NEC. DESIGN, SETTING, AND PARTICIPANTS: In a secondary, prospective, multicenter observational cohort study from January 2010 to February 2014, very low-birth-weight (VLBW, ≤1500 g) infants, within 5 days of birth, were enrolled at 3 level III neonatal intensive care units in Atlanta, Georgia...
March 1, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/26390401/duration-of-cord-clamping-and-neonatal-outcomes-in-very-preterm-infants
#15
Dongli Song, Priya Jegatheesan, Glenn DeSandre, Balaji Govindaswami
BACKGROUND: Delayed cord clamping (DCC, ≥30 s) increases blood volume in newborns and is associated with fewer blood transfusions and short-term neonatal complications. The optimal timing of cord clamping for very preterm infants should maximize placental transfusion without interfering with stabilization and resuscitation. AIM: We compared the effect of different durations of DCC, 30-45 s vs. 60-75 s, on delivery room (DR) and neonatal outcomes in preterm infants <32 weeks gestational age (GA)...
2015: PloS One
https://www.readbyqxmd.com/read/26291780/the-association-between-umbilical-cord-abnormalities-and-the-development-of-non-reassuring-fetal-heart-rate-leading-to-emergent-cesarean-deliveries
#16
COMPARATIVE STUDY
E Weiner, N Fainstein, L Schreiber, R Sagiv, J Bar, M Kovo
OBJECTIVE: To study the contribution of umbilical cord (UC) abnormalities in emergent cesarean deliveries (ECDs) for non-reassuring fetal heart rate (NRFHR) and to explore their association with placental histopathology and neonatal outcome. STUDY DESIGN: Data from 530 ECDs for NRFHR were reviewed for the occurrence of UC abnormalities. Those included the presence of UC entanglements, the number and location of loops, true knots and short cord (<50 cm). Multiple UC entanglements were defined as ⩾ 2 UC loops...
November 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/26181719/red-blood-cell-transfusions-increase-fecal-calprotectin-levels-in-premature-infants
#17
T T B Ho, M W Groer, A A Luciano, A Schwartz, M Ji, B S Miladinovic, A Maheshwari, T L Ashmeade
OBJECTIVE: We hypothesized that red blood cell (RBC) transfusions influence intestinal inflammation in very low birth weight (VLBW) infants. We also suspected that hematocrit (Hct) at transfusions and RBC storage time correlate with intestinal inflammation. STUDY DESIGN: VLBW infants, without major congenital defects, intestinal perforation or necrotizing enterocolitis, were enrolled prospectively. Fecal calprotectin (FC) levels were measured from stool samples collected before and after RBC transfusions...
October 2015: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/26011075/surgical-findings-in-transfusion-associated-necrotizing-enterocolitis
#18
Miguel Couselo, Rosa Fonseca, Lucía Mangas, Juan José Vila
Introduction The extent of intestinal damage in transfusion-associated necrotizing enterocolitis (TNEC) has been scarcely studied. The aim of this investigation was to study surgical findings in TNEC and determine their severity considering the extent of the disease and risk of bowel perforation. Materials and Methods Neonates who required surgical treatment for necrotizing enterocolitis (NEC) were studied retrospectively. Patients who developed NEC within 48 hours after a red blood cell transfusion (RBCT) formed group TR48 and patients who did not receive a RBCT 48 hours before the diagnosis of NEC became group CN (conventional NEC)...
June 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/25991421/interleukin-6-and-c-reactive-protein-load-in-pre-storage-and-post-storage-white-blood-cell-filtered-red-blood-cell-transfusions-in-premature-infants
#19
B Say, F N Sari, S S Oguz, H Degirmencioglu, S Arayici, G Kadioglu Simsek, E G Ibrisim, U Dilmen
OBJECTIVE: Leukocyte contamination during blood transfusion can cause many adverse effects. Filtration can be performed either at bedside during the transfusion or as pre-storage filtration. Pre-storage filtration is superior to bedside filtration because leukocytes are removed prior to storage, thus preventing further adverse effects associated with the storage of these cells. METHODS AND MATERIALS: One hundred and six infants were randomised into two groups: pre-storage filtration (group 1, n = 53) and bedside filtration (group 2, n = 53)...
June 2015: Transfusion Medicine
https://www.readbyqxmd.com/read/25761320/variability-in-splanchnic-tissue-oxygenation-during-preterm-red-blood-cell-transfusion-given-for-symptomatic-anaemia-may-reveal-a-potential-mechanism-of-transfusion-related-acute-gut-injury
#20
Sean M Bailey, Karen D Hendricks-Muñoz, Pradeep V Mally
BACKGROUND: There is increasing evidence indicating an association between red blood cell (RBC) transfusions and necrotising enterocolitis (NEC) in preterm infants, especially late-onset NEC. This phenomenon is referred to as transfusion-related acute gut injury (TRAGI). One theory as to a pathophysiological mechanism is that transfusion may result in an ischemia-reperfusion injury to intestinal tissue. We tested the hypothesis that there is significantly greater variability during transfusion in splanchnic tissue oxygen saturation (SrSO2) than in cerebral tissue oxygen saturation (CrSO2)...
July 2015: Blood Transfusion, Trasfusione del Sangue
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