keyword
https://read.qxmd.com/read/38511171/clinical-characteristics-of-postoperative-necrotizing-enterocolitis-in-patients-with-congenital-jejunoileal-atresia-and-its-risk-factors
#1
JOURNAL ARTICLE
Xiaofeng Xiong, Wei Lu, Fuzhong Xing, Yuan Cai, Jixin Yang, Yuhang Yuan, Jiexiong Feng, Xuyong Chen
OBJECTIVE: To review postoperative necrotizing enterocolitis (NEC) in patients with jejunoileal atresia (JIA) and to explore the potential risk factors related to the concurrence of NEC. METHODS: Patients diagnosed with JIA who received surgical treatment from January 2016 to June 2021 were enrolled. Demographics, viral infection of the fetus, transfusion within 48 hours before NEC, sepsis before JIA repair, pathological and anatomical classification of JIA, combined malformation, occurrence time of NEC after the operation, treatment, and prognosis of patients were analyzed...
2024: World journal of pediatric surgery
https://read.qxmd.com/read/38418993/factors-influencing-necrotizing-enterocolitis-in-premature-infants-in-china-a-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Shuliang Zhao, Huimin Jiang, Yiqun Miao, Wenwen Liu, Yanan Li, Hui Liu, Aihua Wang, Xinghui Cui, Yuanyuan Zhang
BACKGROUND: Necrotizing enterocolitis (NEC) is a multifactorial gastrointestinal disease with high morbidity and mortality among premature infants. However, studies with large samples on the factors of NEC in China have not been reported. This meta-analysis aims to systematically review the literature to explore the influencing factors of necrotizing enterocolitis in premature infants in China and provide a reference for the prevention of NEC. METHODS: PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), Wanfang and VIP databases were systematically searched from inception to February 2023...
February 29, 2024: BMC Pediatrics
https://read.qxmd.com/read/38202069/clinical-dilemma-involving-treatments-for-very-low-birth-weight-infants-and-the-potential-risk-of-necrotizing-enterocolitis-a-narrative-literature-review
#3
REVIEW
Shigeo Iijima
Necrotizing enterocolitis (NEC) is a critical gastrointestinal emergency with substantial morbidity and mortality risks, especially for very low-birth-weight (VLBW) infants, and unclear multifactorial pathophysiology. Whether common treatments for VLBW infants increase the NEC risk remains controversial. Indomethacin (utilized for patent ductus arteriosus) offers benefits but is concerning because of its vasoconstrictive impact on NEC susceptibility. Similarly, corticosteroids used to treat bronchopulmonary dysplasia may increase vulnerability to NEC by compromising immunity and altering the mesenteric blood flow...
December 22, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38197096/risk-factors-for-brain-injury-in-premature-infants-with-twin-to-twin-transfusion-syndrome-a-retrospective-cohort-study
#4
JOURNAL ARTICLE
Te Jiang, Ruimiao Bai, Chengmiao Xie, Henhen Guo, Zhankui Li, Jinqi Ma
BACKGROUND: Brain injury (BI) is prevalent in premature infants with twin-to-twin transfusion syndrome (TTTS), while risk factors of BI in these patients remains unknown. Our study aims to discern potential risk factors that contribute to BI in premature infants with TTTS. METHODS: We conducted a retrospective cohort and analyzed clinical data of premature infants diagnosed with TTTS at the Northwest Women's and Children's Hospital between January 1, 2015 and January 1, 2020...
December 26, 2023: Translational Pediatrics
https://read.qxmd.com/read/37738923/the-differential-associative-relationship-between-early-risk-factors-neonatal-morbidities-and-early-neurodevelopmental-outcome-in-preterm-infants-29-weeks-gestation
#5
JOURNAL ARTICLE
Hai-Bo Huang, Matthew Hicks, Qian-Shen Zhang, Man Joe Watt, Fang Lin, Xue-Qin Wan, Po-Yin Cheung
BACKGROUND: Very preterm infants of <29 weeks' gestation are at high risk for adverse neurodevelopment due to multiple risk factors in the early stages of life. There is little information regarding the associative effects of risk factors in early life, neonatal morbidities and subsequent neurodevelopmental outcomes. AIMS: Investigate the association of early neurodevelopmental outcomes, neonatal complications and the risk factors in the early hours of life in a cohort of preterm infants <29 weeks' gestational age...
September 13, 2023: Early Human Development
https://read.qxmd.com/read/37348546/impact-of-delayed-cord-clamping-on-red-blood-cell-transfusion-and-related-outcomes-in-very-low-birth-weight-infants
#6
JOURNAL ARTICLE
Mayuri Patel, Mathangi Gopalakrishnan, Sripriya Sundararajan
OBJECTIVE:  Delayed cord clamping (DCC) for 30 to 60 seconds after birth facilitates placental transfusion, increases blood volume, and decreases red blood cell (RBC) transfusion in preterm infants. Study objective was to determine (1) RBC transfusion burden over a 5-year period, (2) impact of DCC practice on RBC transfusions, and (3) association of RBC transfusion on outcomes in very low birthweight (VLBW) preterm infants. STUDY DESIGN:  A retrospective medical chart review was performed in 787 VLBW infants between 2016 and 2020...
July 29, 2023: American Journal of Perinatology
https://read.qxmd.com/read/37108730/-selenop-rs3877899-variant-affects-the-risk-of-developing-advanced-stages-of-retinopathy-of-prematurity-rop
#7
JOURNAL ARTICLE
Ewa Strauss, Danuta Januszkiewicz-Lewandowska, Alicja Sobaniec, Anna Gotz-Więckowska
The significance of selenoproteins for the incidence of prematurity and oxidative-damage-related diseases in premature newborns is poorly understood. The latter are at risk for ROP as well as BPD, IVH, PDA, RDS, and NEC, which is particularly high for newborns with extremely low gestational age (ELGA) and extremely low birth weight (ELBW). This study evaluates the hypothesis that variation in the selenoprotein-encoding genes SELENOP , SELENOS , and GPX4 affects the risk of ROP and other comorbidities. The study included infants born ≤ 32 GA, matched for onset and progression of ROP into three groups: no ROP, spontaneously remitting ROP, and ROP requiring treatment...
April 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36631077/investigation-of-biomarkers-in-a-rare-case-of-fulminant-necrotizing-enterocolitis-in-a-preterm-infant
#8
JOURNAL ARTICLE
Toshihiko Nakamura, Shota Inoue, Kana Ito, Eisuke Fukama, Tomoaki Nomura, Daisuke Hatanaka, Michiko Kusakari, Hidehiro Takahashi, Shingo Yamada
We encountered a very rare case of fulminant necrotizing enterocolitis (F-NEC) in a preterm male baby. The course of NEC and sepsis in this case was clearly different from the usual course. After onset at 14 days of life, catheter-related bloodstream infection was first assumed, and antibiotics and γ-globulin administration were started. However, 12 hours after onset, the baby's abdominal distension increased remarkably, and his entire abdominal wall turned red to purple. Escherichia coli were isolated from the blood culture, but the catheter tip culture was negative...
January 12, 2023: Fukushima Journal of Medical Science
https://read.qxmd.com/read/35644997/neonatal-outcome-in-twin-to-twin-transfusion-syndrome-not-treated-with-fetoscopic-laser-surgery
#9
JOURNAL ARTICLE
Elina A Lopriore, Femke Slaghekke, E Joanne Verweij, Monique C Haak, Annemieke J M Middeldorp, Enrico Lopriore
The aim of this study was to describe the neonatal management and outcome in monochorionic twins with twin-to-twin transfusion syndrome (TTTS) not treated with fetoscopic laser surgery. All consecutive live-born neonates with TTTS managed at our center between 2002 and 2021 were included in this retrospective study. Neonatal outcome was assessed in 44 twin pairs with TTTS not treated with laser (nonlaser group) compared to a control group of 88 twin pairs with TTTS successfully treated with laser (laser group), matched for gestational age at birth...
February 2022: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://read.qxmd.com/read/35115712/the-short-term-effects-of-rbc-transfusions-on-intestinal-injury-in-preterm-infants
#10
JOURNAL ARTICLE
Willemien S Kalteren, Arend F Bos, Klasien A Bergman, Willem van Oeveren, Jan B F Hulscher, Elisabeth M W Kooi
BACKGROUND: Anemic preterm infants may require red blood cell (RBC) transfusions to maintain sufficient oxygen supply to vital organs. Transfusion treatment, however, may have adverse intestinal effects. We aimed to investigate the short-term effects of RBC transfusions, hypothesizing to find signs of oxidative stress and intestinal injury, possibly related to levels of splanchnic (re-)oxygenation. METHODS: We prospectively included preterm infants (gestational age < 32 weeks)...
February 4, 2022: Pediatric Research
https://read.qxmd.com/read/34907357/neonatal-anemia-relates-to-intestinal-injury-in-preterm-infants
#11
JOURNAL ARTICLE
Willemien S Kalteren, Arend F Bos, Willem van Oeveren, Jan B F Hulscher, Elisabeth M W Kooi
BACKGROUND: Anemia is associated with decreased tissue oxygenation in preterm infants and may contribute to developing necrotizing enterocolitis (NEC). We aimed to investigate whether hemoglobin level is associated with intestinal injury, by comparing anemic infants 10 days prior to red blood cell (RBC) transfusion with non-anemic controls. METHODS: A nested case-control study in which we matched anemic preterms (gestational age (GA) < 32 weeks) with non-anemic controls (1:1), based on GA, birth weight (BW), and postnatal age...
May 2022: Pediatric Research
https://read.qxmd.com/read/34477851/association-of-blood-donor-sex-and-age-with-outcomes-in-very-low-birth-weight-infants-receiving-blood-transfusion
#12
JOURNAL ARTICLE
Ravi M Patel, Joshua Lukemire, Neeta Shenvi, Connie Arthur, Sean R Stowell, Martha Sola-Visner, Kirk Easley, John D Roback, Ying Guo, Cassandra D Josephson
Importance: There are conflicting data on the association between blood donor characteristics and outcomes among patients receiving transfusions. Objective: To evaluate the association of blood donor sex and age with mortality or serious morbidity in very low-birth-weight (VLBW) infants receiving blood transfusions. Design, Setting, and Participants: This is a cohort study using data collected from 3 hospitals in Atlanta, Georgia. VLBW infants (≤1500 g) who received red blood cell (RBC) transfusion from exclusively male or female donors were enrolled from January 2010 to February 2014...
September 1, 2021: JAMA Network Open
https://read.qxmd.com/read/34435026/neonatal-necrotizing-enterocolitis-caused-by-umbilical-arterial-catheter-associated-abdominal-aortic-embolism-a-case-report
#13
Xi Huang, Yan-Ling Hu, Yuan Zhao, Qiong Chen, Ying-Xin Li
BACKGROUND: Reports of necrotizing enterocolitis (NEC) caused by umbilical arterial catheter (UAC)-associated abdominal aortic embolism in neonates are rare. Herein, we report the case of an extremely low birth weight (ELBW) infant with NEC caused by UAC-associated abdominal aortic embolism. CASE SUMMARY: A female infant, aged 21 min and weighing 830 g at 28+6 wk of gestational age, was referred to our hospital because of premature birth and shallow breathing. The patient was diagnosed with ELBW, neonatal respiratory distress syndrome, neonatal intrauterine infection, and neonatal asphyxia...
August 6, 2021: World Journal of Clinical Cases
https://read.qxmd.com/read/34392969/blood-group-ab-is-associated-with-poor-outcomes-in-infants-with-necrotizing-enterocolitis
#14
JOURNAL ARTICLE
Raquel Dos Santos Martins, Elisabeth M W Kooi, Willemien S Kalteren, Klaas Poelstra, Arend F Bos, Jan B F Hulscher
BACKGROUND: Necrotizing enterocolitis (NEC) is a neonatal disease associated with necrosis and perforation of the bowel. We investigated the association between blood group and NEC outcomes and the potential contribution of fetal-maternal blood group incompatibility. METHODS: Retrospective study including all preterm-born infants with NEC (≥ Bell's stage IIa) admitted to our NICU between January 2008 and October 2019. We analyzed the association between infants' blood groups and fetal-maternal blood group incompatibility with Bell stage severity, need for surgery, and mortality due to NEC...
July 18, 2021: Journal of Pediatric Surgery
https://read.qxmd.com/read/33378779/the-outcome-of-blood-transfusions-in-conservative-and-surgical-necrotizing-enterocolitis-and-spontaneous-intestinal-perforation
#15
REVIEW
Kristiina Karila, Antti Koivusalo
INTRODUCTION:  In necrotizing enterocolitis (NEC), blood transfusions (BTs) are a disputed factor concerning the etiology and the outcome. We assessed retrospectively the effects of preonset BT on the outcome of NEC and spontaneous intestinal perforation (SIP). MATERIALS AND METHODS:  With ethical consent, we reviewed the hospital records of 113 neonates from 2002 to 2019 with surgical NEC (NECs) ( n  = 57), conservatively treated NEC (NECc) ( n  = 20), and SIP ( n  = 36)...
June 2022: European Journal of Pediatric Surgery
https://read.qxmd.com/read/33103394/-necrotizing-enterocolitis-an-ongoing-challenge
#16
JOURNAL ARTICLE
Noa Greenberg-Kushnir, Irit Schushan-Eisen, Naama Elisha, Ben Peleg, Leah Leibovitch, Tzipora Strauss
Necrotizing enterocolitis (NEC) is a major cause for morbidity and mortality among neonates, especially among low birth weight premature infants. Even though NEC has been highly investigated during the last few decades, understanding of the pathogenesis is still relatively poor. Throughout the years protective measures, as well as risk factors, were identified, but there is still no clear prevention strategy, and the percentage of neonates suffering of NEC was not changed. Moreover, the treatment approach is controversial in many circumstances other than a few clear surgical indications...
October 2020: Harefuah
https://read.qxmd.com/read/32769638/neonatal-and-maternal-composite-adverse-outcomes-among-low-risk-nulliparous-women-compared-with-multiparous-women-at-39-41-weeks-of-gestation
#17
JOURNAL ARTICLE
Suneet P Chauhan, Madeline Murguia Rice, William A Grobman, Jennifer Bailit, Uma M Reddy, Ronald J Wapner, Michael W Varner, John M Thorp, Steve N Caritis, Mona Prasad, Alan T N Tita, George R Saade, Yoram Sorokin, Dwight J Rouse, Jorge E Tolosa
OBJECTIVE: To estimate whether the frequency of adverse maternal and neonatal outcomes differs between low-risk nulliparous and multiparous women at 39-41 weeks of gestation. METHODS: This is a secondary analysis of an observational obstetrics cohort of maternal-neonatal dyads at 25 hospitals. Low-risk women with nonanomalous singletons who delivered between 39 0/7 and 41 6/7 weeks of gestation were included. The composite neonatal adverse outcome included 5-minute Apgar score less than five, ventilator support or cardiopulmonary resuscitation, seizure, hypoxic ischemic encephalopathy, sepsis, bronchopulmonary dysplasia, persistent pulmonary hypertension, necrotizing enterocolitis, birth injury or perinatal death...
August 6, 2020: Obstetrics and Gynecology
https://read.qxmd.com/read/32601461/role-of-platelets-in-neonatal-necrotizing-enterocolitis
#18
REVIEW
Akhil Maheshwari
Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and is a leading cause of morbidity and mortality in infants born between 23 and 28 weeks of gestation. Fifty to 95% of all infants with NEC develop thrombocytopenia (platelet counts <150 × 109 /L) within 24-72 h of receiving this diagnosis. In many patients, thrombocytopenia is severe and is treated with one or more platelet transfusions. However, the underlying mechanism(s) and biological implications of NEC-related thrombocytopenia remain unclear...
April 2021: Pediatric Research
https://read.qxmd.com/read/32439119/transfusion-related-gut-injury-and-necrotizing-enterocolitis
#19
REVIEW
Allison Thomas Rose, Vivek Saroha, Ravi Mangal Patel
Necrotizing enterocolitis (NEC) accounts for 10% of deaths in neonatal intensive care units. Several causal mechanisms are likely to lead to a final common disease phenotype. This article summarizes recent data on NEC following red blood cell (RBC) transfusion, with a focus on the most recent literature and ongoing trials. It highlights potential mechanisms from preclinical and human physiologic studies. It also discusses the role of feeding during RBC transfusion and the risk of NEC. Ongoing randomized trials will provide important data on how liberal or conservative approaches to RBC transfusion influence the risk of NEC...
June 2020: Clinics in Perinatology
https://read.qxmd.com/read/32366656/targeted-inhibition-of-thrombin-attenuates-murine-neonatal-necrotizing-enterocolitis
#20
JOURNAL ARTICLE
Kopperuncholan Namachivayam, Krishnan MohanKumar, Darla R Shores, Sunil K Jain, Jennifer Fundora, Allen D Everett, Ling He, Hua Pan, Samuel A Wickline, Akhil Maheshwari
Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and an orphan disease with no specific treatment. Most patients with confirmed NEC develop moderate-severe thrombocytopenia requiring one or more platelet transfusions. Here we used our neonatal murine model of NEC-related thrombocytopenia to investigate mechanisms of platelet depletion associated with this disease [K. Namachivayam, K. MohanKumar, L. Garg, B. A. Torres, A. Maheshwari, Pediatr. Res. 81, 817-824 (2017)]. In this model, enteral administration of immunogen trinitrobenzene sulfonate (TNBS) in 10-d-old mouse pups produces an acute necrotizing ileocolitis resembling human NEC within 24 h, and these mice developed thrombocytopenia at 12 to 15 h...
May 19, 2020: Proceedings of the National Academy of Sciences of the United States of America
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