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https://www.readbyqxmd.com/read/28814875/suicidal-and-homicidal-tendencies-after-lyme-disease-an-ignored-problem
#1
COMMENT
Aitzaz Munir, Muhammad Aadil, Ahmad Rehan Khan
No abstract text is available yet for this article.
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28814545/metabolic-differentiation-of-early-lyme-disease-from-southern-tick-associated-rash-illness-stari
#2
Claudia R Molins, Laura V Ashton, Gary P Wormser, Barbara G Andre, Ann M Hess, Mark J Delorey, Mark A Pilgard, Barbara J Johnson, Kristofor Webb, M Nurul Islam, Adoracion Pegalajar-Jurado, Irida Molla, Mollie W Jewett, John T Belisle
Lyme disease, the most commonly reported vector-borne disease in the United States, results from infection with Borrelia burgdorferi. Early clinical diagnosis of this disease is largely based on the presence of an erythematous skin lesion for individuals in high-risk regions. This, however, can be confused with other illnesses including southern tick-associated rash illness (STARI), an illness that lacks a defined etiological agent or laboratory diagnostic test, and is coprevalent with Lyme disease in portions of the eastern United States...
August 16, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28796635/detecting-and-attributing-health-burdens-to-climate-change
#3
Kristie L Ebi, Nicholas H Ogden, Jan C Semenza, Alistair Woodward
BACKGROUND: Detection and attribution of health impacts caused by climate change uses formal methods to determine a) whether the occurrence of adverse health outcomes has changed, and b) the extent to which that change could be attributed to climate change. There have been limited efforts to undertake detection and attribution analyses in health. OBJECTIVE: Our goal was to show a range of approaches for conducting detection and attribution analyses. RESULTS: Case studies for heatwaves, Lyme disease in Canada, and Vibrio emergence in northern Europe highlight evidence that climate change is adversely affecting human health...
August 7, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28794875/the-humtick-study-protocol-for-a-prospective-cohort-study-on-post-treatment-lyme-disease-syndrome-and-the-disease-and-cost-burden-of-lyme-borreliosis-in-belgium
#4
Laurence Geebelen, Tinne Lernout, Benoît Kabamba-Mukadi, Veroniek Saegeman, Hein Sprong, Steven Van Gucht, Philippe Beutels, Niko Speybroeck, Katrien Tersago
BACKGROUND: In Belgium, different routine surveillance systems are in place to follow-up Lyme borreliosis trends. However, accurate data on the disease and monetary burden for the different clinical manifestations are lacking. Despite recommended antibiotic treatment, a proportion of Lyme patients report persisting aspecific symptoms for six months or more (e.g. fatigue, widespread musculoskeletal pain, cognitive difficulties), a syndrome now named "post-treatment Lyme disease syndrome" (PTLDS)...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28780833/-research-progress-in-laboratory-diagnosis-of-lyme-disease
#5
D M Shi, D D Li, L Song
No abstract text is available yet for this article.
June 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28777206/lyme-borreliosis-in-children-a-tertiary-referral-hospital-based-retrospective-analysis
#6
Amara Nassar-Sheikh Rashid, Michael Boele van Hensbroek, Marion Kolader, Joppe W Hovius, Dasja Pajkrt
BACKGROUND: Lyme borreliosis (LB) is an endemic disease in adults in Western countries. Although children may also be infected, paediatric studies on LB are scarce. This study aims to estimate the incidence of LB among children with a clinical suspicion for Lyme in a tertiary referral center in the Netherlands. METHODS: Patient chart data on medical history, clinical signs and symptoms, diagnostic test results and diagnoses were collected using standardized case record forms...
August 1, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28775250/modulation-of-the-tick-gut-milieu-by-a-secreted-tick-protein-favors-borrelia-burgdorferi-colonization
#7
Sukanya Narasimhan, Tim J Schuijt, Nabil M Abraham, Nallakkandi Rajeevan, Jeroen Coumou, Morven Graham, Andrew Robson, Ming-Jie Wu, Sirlei Daffre, Joppe W Hovius, Erol Fikrig
The Lyme disease agent, Borrelia burgdorferi, colonizes the gut of the tick Ixodes scapularis, which transmits the pathogen to vertebrate hosts including humans. Here we show that B. burgdorferi colonization increases the expression of several tick gut genes including pixr, encoding a secreted gut protein with a Reeler domain. RNA interference-mediated silencing of pixr, or immunity against PIXR in mice, impairs the ability of B. burgdorferi to colonize the tick gut. PIXR inhibits bacterial biofilm formation in vitro and in vivo...
August 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28771127/interactions-between-host-immune-response-and-antigenic-variation-that-control-borrelia-burgdorferi-population-dynamics
#8
Wei Zhou, Dustin Brisson
The population dynamics of pathogens within hosts result from interactions between host immune responses and mechanisms of the pathogen to evade or resist immune responses. Vertebrate hosts have evolved adaptive immune responses to eliminate the infection, while many pathogens evade immune clearance through altering surface antigens. Such interactions can result in a characteristic pattern of pathogen population dynamics within hosts consisting of population growth after infection, rapid population decline following specific immune responses, followed by persistence at low densities during a chronic infection stage...
August 4, 2017: Microbiology
https://www.readbyqxmd.com/read/28770818/correction-lyme-borreliosis
#9
Allen C Steere, Strle Franc, Gary P Wormser, Linden T Hu, John A Branda, Joppe W R Hovius, Xin Li, Paul S Mead
This corrects the article DOI: 10.1038/nrdp.2016.90.
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28768731/improved-serodiagnostic-performance-for-lyme-disease-by-use-of-two-recombinant-proteins-in-elisa-as-compared-to-standardized-two-tier-testing
#10
Gary L Bradshaw, R Kelley Thueson, Todd J Uriona
The most reliable test method for the serological confirmation of Lyme Disease (LD) is a 2-tiered method recommended by the CDC in 1995. The first-tier test is a low specificity ELISA test and the second-tier tests are higher specificity IgG and IgM Western blots. This study describes the selection of two Borrelia burgdorferi-recombinant proteins and evaluation of their performance in a simple 1-tier test for the serological confirmation of LD. These two proteins were generated from (a) the full length dbpA gene combined with the invariable region 6 of the VlsE gene (dbpA/C6) and (b) the full length OspC gene...
August 2, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28754599/bioassays-to-evaluate-non-contact-spatial-repellency-contact-irritancy-and-acute-toxicity-of-permethrin-treated-clothing-against-nymphal-ixodes-scapularis-ticks
#11
Lars Eisen, Dominic Rose, Robert Prose, Nicole E Breuner, Marc C Dolan, Karen Thompson, Neeta Connally
Summer-weight clothing articles impregnated with permethrin are available as a personal protective measure against human-biting ticks in the United States. However, very few studies have addressed the impact of contact with summer-weight permethrin-treated textiles on tick vigor and behavior. Our aim was to generate new knowledge of how permethrin-treated textiles impact nymphal Ixodes scapularis ticks, the primary vectors in the eastern United States of the causative agents of Lyme disease, human anaplasmosis, and human babesiosis...
July 1, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28748396/disagreement-between-the-results-from-three-commercial-tests-for-the-detection-of-borrelia-specific-serum-antibodies-in-the-netherlands-associated-with-antibiotic-treatment-for-lyme-borreliosis-a-retrospective-study
#12
T van Gorkom, K Kremer, W Voet, D W Notermans, B J M Vlaminckx, S U C Sankatsing, S F T Thijsen
The diagnosis of Lyme borreliosis is challenging because of the often non-specific symptoms and persisting antibodies after infection. We investigated the diagnostic characteristics of two enzyme-linked immunosorbent assays (ELISAs) and an immunoblot for the detection of Borrelia-specific serum antibodies using different test strategies in individuals with and without antibiotic treatment for Lyme borreliosis. This retrospective study included healthy individuals, patients with active Lyme neuroborreliosis and patients treated for Lyme neuroborreliosis...
July 26, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28742918/deceptive-lyme-disease-diagnosis-linked-with-serious-infections
#13
(no author information available yet)
No abstract text is available yet for this article.
July 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28742149/predicting-the-risk-of-lyme-borreliosis-after-a-tick-bite-using-a-structural-equation-model
#14
Agnetha Hofhuis, Jan van de Kassteele, Hein Sprong, Cees C van den Wijngaard, Margriet G Harms, Manoj Fonville, Arieke Docters van Leeuwen, Mariana Simões, Wilfrid van Pelt
BACKGROUND: Understanding and quantification of the risk of Lyme borreliosis after a tick bite can aid development of prevention strategies against Lyme borreliosis. METHODS: We used 3,525 single tick bite reports from three large prospective studies on the transmission risk of tick-borne pathogens to humans, with 50 reports of Lyme borreliosis during the follow-up period, among 1,973 reports with known outcome. A structural equation model was applied to estimate the risk of Lyme borreliosis after a tick bite, and quantify the influence of: developmental stage of the tick, detection of Borrelia burgdorferi s...
2017: PloS One
https://www.readbyqxmd.com/read/28736624/lyme-and-dopaminergic-function-hypothesizing-reduced-reward-deficiency-symptomatology-by-regulating-dopamine-transmission
#15
Kenneth Blum, Edward J Modestino, Marcelo Febo, Bruce Steinberg, Thomas McLaughlin, Lyle Fried, David Baron, David Siwicki, Rajendra D Badgaiyan
The principal vector of Lyme disease in the United States is Ixodes scapularis: black legged or deer ticks. There is increased evidence that those infected may be plagued by anxiety or depression as well. Researchers have identified transcripts coding for two putative cytosolic sulfotransferases in these ticks, which recognized phenolic monoamines as their substrates. It is hypothesized that protracted Lyme disease sequelae may be due to impairment of dopaminergic function of the brain reward circuitry. The subsequent recombinant proteins exhibited sulfotransferase function against two neurotransmitters: dopamine and octopamine...
May 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/28735651/the-effect-of-artesunate-on-short-term-memory-in-lyme-borreliosis
#16
B K Puri, J S Hakkarainen-Smith, J A Monro
Lyme borreliosis is associated with memory deficits. While this may be related to cerebral infection by Borrelia bacteria, it may also be caused by concomitant co-infection by Babesia protozoa. The anti-malarial artemisinin-derivative artesunate has been shown to be effective against a number of Babesia species and to have efficacy against human cerebral malaria. We hypothesised that concomitant administration of artesunate in Lyme borreliosis patients would help alleviate the severity of self-reported short-term memory impairment...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28730535/the-recombead-borrelia-antibody-index-cxcl13-and-total-igm-index-for-laboratory-diagnosis-of-lyme-neuroborreliosis-in-children
#17
B H Skogman, M Lager, A J Henningsson, I Tjernberg
For laboratory diagnostics of Lyme neuroborreliosis (LNB), the recomBead Borrelia antibody index (AI) assay has shown promising results in a mixed age population, but has not previously been evaluated with specific focus on paediatric patients. The aim of the study was to evaluate the recomBead Borrelia AI assay in cerebrospinal fluid (CSF) for the laboratory diagnosis of LNB in children. We also wanted to explore whether early markers, such as CXCL13 in CSF and/or total IgM index could be useful as complementary diagnostic tools...
July 20, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28730326/infectious-diseases-causing-autonomic-dysfunction
#18
REVIEW
Francisco Javier Carod Artal
OBJECTIVES: To review infectious diseases that may cause autonomic dysfunction. METHODS: Review of published papers indexed in medline/embase. RESULTS: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Autonomic dysfunction is relatively common in HIV-infected patients and heart rate variability is reduced even in early stages of infection...
July 20, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28727515/brave-new-worlds-the-expanding-universe-of-lyme-disease
#19
Brandee L Stone, Yvonne Tourand, Catherine A Brissette
Projections around the globe suggest an increase in tick-vectored disease incidence and distribution, and the potential for emergence of novel tick-borne pathogens. Lyme disease is the most common reported tick-borne illness in the Unites States and is prevalent throughout much of central Europe. In recent years, the worldwide burden of Lyme disease has increased and extended into regions and countries where the disease was not previously reported. In this review, we discuss the trends for increasing Lyme disease, and examine the factors driving Lyme disease expansion, including the effect of climate change on the spread of vector Ixodid ticks and reservoir hosts; and the impacts of increased awareness on disease reporting and diagnosis...
July 20, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28726624/lyme-borreliosis-in-finland-1995-2014
#20
Eeva Sajanti, Mikko Virtanen, Otto Helve, Markku Kuusi, Outi Lyytikäinen, Jukka Hytönen, Jussi Sane
We investigated the epidemiology of Lyme borreliosis (LB) in Finland for the period 1995-2014 by using data from 3 different healthcare registers. We reviewed data on disseminated LB cases from the National Infectious Diseases Register (21,051 cases) and the National Hospital Discharge Register (10,402 cases) and data on primary LB (erythema migrans) cases from the Register for Primary Health Care Visits (11,793 cases). Incidence of microbiologically confirmed disseminated LB cases increased from 7/100,000 population in 1995 to 31/100,000 in 2014...
August 2017: Emerging Infectious Diseases
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