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https://www.readbyqxmd.com/read/29469222/borrelia-burgdorferi-infection-and-lyme-disease-in-north-american-horses-a-consensus-statement
#1
T J Divers, R B Gardner, J E Madigan, S G Witonsky, J J Bertone, E L Swinebroad, S E Schutzer, A L Johnson
Borrelia burgdorferi infection is common in horses living in Lyme endemic areas and the geographic range for exposure is increasing. Morbidity after B. burgdorferi infection in horses is unknown. Documented, naturally occurring syndromes attributed to B. burgdorferi infection in horses include neuroborreliosis, uveitis, and cutaneous pseudolymphoma. Although other clinical signs such as lameness and stiffness are reported in horses, these are often not well documented. Diagnosis of Lyme disease is based on exposure to B...
February 22, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29467195/direct-molecular-detection-and-genotyping-of-borrelia-burgdorferi-sensu-lato-in-the-cerebrospinal-fluid-of-children-with-lyme-neuroborreliosis
#2
Bjørn Barstad, Hanne Quarsten, Dag Tveitnes, Sølvi Noraas, Ingvild S Ask, Maryam Saeed, Franziskus Bosse, Grete Vigemyr, Ilka Huber, Knut Øymar
The current diagnostic marker of Lyme neuroborreliosis (LNB), Borrelia burgdorferi sensu lato (Bb) antibody index (AI) in the cerebrospinal fluid (CSF), has insufficient sensitivity in the early phase of LNB. We aimed to elucidate the diagnostic value of Bb PCR in CSF from children with symptoms suggestive of LNB and explore Bb genotypes associated with LNB in children. Children were prospectively included into predefined groups with high or low likelihood of LNB based on diagnostic guidelines (LNB symptoms, CSF pleocytosis and Bb antibodies), or detection of other causative agents...
February 21, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29467162/septic-arthritis-versus-lyme-arthritis-a-case-of-diagnostic-difficulty
#3
Brenna Keane, Jessica Top, Michael Burbridge
No abstract text is available yet for this article.
February 21, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29460492/cerebrospinal-fluid-lyme-multiplex-assay-results-are-not-diagnostic-in-horses-with-neuroborreliosis
#4
Amy L Johnson, Laura K Johnstone, Darko Stefanovski
BACKGROUND: The accuracy of the Lyme multiplex assay for the diagnosis of neuroborreliosis in horses is unknown. HYPOTHESIS/OBJECTIVES: To describe Lyme multiplex results in horses with a postmortem diagnosis of neuroborreliosis. The hypothesis was that paired serum and cerebrospinal fluid (CSF) results and a CSF : serum ratio would allow differentiation of horses with neuroborreliosis from those with other neurologic diseases. ANIMALS: Ninety horses that had neurologic examinations, serum and CSF Lyme multiplex analyses, and postmortem examination of the nervous system performed...
February 20, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29456970/the-complement-binding-and-inhibitory-protein-cbia-of-borrelia-miyamotoi-degrades-extracellular-matrix-components-by-interacting-with-plasmin-ogen
#5
Ngoc T T Nguyen, Florian Röttgerding, Gayatri Devraj, Yi-Pin Lin, Arno Koenigs, Peter Kraiczy
The emerging relapsing fever spirochete Borrelia ( B .) miyamotoi is transmitted by ixodid ticks and causes the so-called hard tick-borne relapsing fever or B. miyamotoi disease (BMD). More recently, we identified a surface-exposed molecule, CbiA exhibiting complement binding and inhibitory capacity and rendering spirochetes resistant to complement-mediated lysis. To gain deeper insight into the molecular principles of B. miyamotoi -host interaction, we examined CbiA as a plasmin(ogen) receptor that enables B...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29453420/a-multiplex-serologic-platform-for-diagnosis-of-tick-borne-diseases
#6
Rafal Tokarz, Nischay Mishra, Teresa Tagliafierro, Stephen Sameroff, Adrian Caciula, Lokendrasingh Chauhan, Jigar Patel, Eric Sullivan, Azad Gucwa, Brian Fallon, Marc Golightly, Claudia Molins, Martin Schriefer, Adriana Marques, Thomas Briese, W Ian Lipkin
Tick-borne diseases are the most common vector-borne diseases in the United States, with serology being the primary method of diagnosis. We developed the first multiplex, array-based assay for serodiagnosis of tick-borne diseases called the TBD-Serochip. The TBD-Serochip was designed to discriminate antibody responses to 8 major tick-borne pathogens present in the United States, including Anaplasma phagocytophilum, Babesia microti, Borrelia burgdorferi, Borrelia miyamotoi, Ehrlichia chaffeensis, Rickettsia rickettsii, Heartland virus and Powassan virus...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452400/sleep-quality-in-well-defined-lyme-disease-a-clinical-cohort-study-in-maryland
#7
Eric R Weinstein, Alison W Rebman, John N Aucott, Doug Johnson-Greene, Kathleen T Bechtold
Study Objectives: Lyme disease (LD) is the most common vector-borne disease in the United States. Approximately 5-15% of patients develop post-antibiotic treatment symptoms termed post-treatment LD syndrome (PTLDS). The primary objective of this study was to examine and quantify sleep quality among patients with early Lyme disease during the acute and convalescent periods, including among the subset who met criteria for PTLDS. Methods: This paper draws from a clinical cohort study of early LD participants (n=122) and a sub-cohort of individuals who later met criteria for PTLDS (n=6)...
February 14, 2018: Sleep
https://www.readbyqxmd.com/read/29448923/data-driven-predictions-and-novel-hypotheses-about-zoonotic-tick-vectors-from-the-genus-ixodes
#8
Laura Hyesung Yang, Barbara A Han
BACKGROUND: With the resurgence of tick-borne diseases such as Lyme disease and the emergence of new tick-borne pathogens such as Powassan virus, understanding what distinguishes vectors from non-vectors, and predicting undiscovered tick vectors is a crucial step towards mitigating disease risk in humans. We aimed to identify intrinsic traits that predict which Ixodes tick species are confirmed or strongly suspected to be vectors of zoonotic pathogens. METHODS: We focused on the well-studied tick genus Ixodes from which many species are known to transmit zoonotic diseases to humans...
February 15, 2018: BMC Ecology
https://www.readbyqxmd.com/read/29447935/biofilms-busters-to-improve-the-detection-of-borrelia-using-pcr
#9
Alexis Lacout, Véronique Dacher, Mostafa El Hajjam, Pierre Yves Marcy, Christian Perronne
Lyme disease is an affection caused by a spirochete infection called Borrelia Burgdorferi which may harbor a varied and misleading clinical symptomatology. The serology tests commonly used for diagnosis show a wide sensitivity varying from 34% to 70,5%, leaving many infected patients with false negative tests. Alternative techniques such as polymerase chain reaction (PCR) could be helpful but not conclusive enough. Using biofilm busters, such as stevia and serratiopeptidase, could lead to bacterial blood release, thus increasing the spirochete load, making PCR test more sensitive, thus improving the patient's diagnosis and management...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29446403/humanizing-the-digital-revolution-the-secret-life-of-yeast-and-lyme-disease-through-a-climate-lens-books-in-brief
#10
Barbara Kiser
No abstract text is available yet for this article.
February 15, 2018: Nature
https://www.readbyqxmd.com/read/29444855/role-of-glutathione-metabolism-in-host-defense-against-borrelia-burgdorferi-infection
#11
Mariska Kerstholt, Hedwig Vrijmoeth, Ekta Lachmandas, Marije Oosting, Mihaela Lupse, Mirela Flonta, Charles A Dinarello, Mihai G Netea, Leo A B Joosten
Pathogen-induced changes in host cell metabolism are known to be important for the immune response. In this study, we investigated how infection with the Lyme disease-causing bacterium Borrelia burgdorferi ( Bb ) affects host metabolic pathways and how these metabolic pathways may impact host defense. First, metabolome analysis was performed on human primary monocytes from healthy volunteers, stimulated for 24 h with Bb at low multiplicity of infection (MOI). Pathway analysis indicated that glutathione (GSH) metabolism was the pathway most significantly affected by Bb Specifically, intracellular levels of GSH increased on average 10-fold in response to Bb exposure...
February 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29443061/detecting-the-lyme-disease-spirochete-borrelia-burgdorferi-in-ticks-using-nested-pcr
#12
Melanie K B Wills, Andrea M Kirby, Vett K Lloyd
Lyme disease is a serious vector-borne infection that is caused by the Borrelia burgdorferi sensu lato family of spirochetes, which are transmitted to humans through the bite of infected Ixodes ticks. The primary etiological agent in North America is Borrelia burgdorferi sensu stricto. As geographic risk regions expand, it is prudent to support robust surveillance programs that can measure tick infection rates, and communicate findings to clinicians, veterinarians, and the general public. The molecular technique of nested polymerase chain reaction (nPCR) has long been used for this purpose, and it remains a central, inexpensive, and robust approach in the detection of Borrelia in both ticks and wildlife...
February 4, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29440061/ticks-transmitting-lyme-disease-are-found-in-a-third-of-britain-mainly-the-south
#13
Nigel Hawkes
No abstract text is available yet for this article.
February 12, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29438352/the-financial-implications-of-a-well-hidden-and-ignored-chronic-lyme-disease-pandemic
#14
Marcus Davidsson
1 million people are predicted to get infected with Lyme disease in the USA in 2018. Given the same incidence rate of Lyme disease in Europe as in the USA, then 2.4 million people will get infected with Lyme disease in Europe in 2018. In the USA by 2050, 55.7 million people (12% of the population) will have been infected with Lyme disease. In Europe by 2050, 134.9 million people (17% of the population) will have been infected with Lyme disease. Most of these infections will, unfortunately, become chronic. The estimated treatment cost for acute and chronic Lyme disease for 2018 for the USA is somewhere between 4...
February 13, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29431297/lyme-disease-surveillance-in-the-united-states-looking-for-ways-to-cut-the-gordian-knot
#15
M L Cartter, R Lynfield, K A Feldman, S A Hook, A F Hinckley
Current surveillance methods have been useful to document geographic expansion of Lyme disease in the United States and to monitor the increasing incidence of this major public health problem. Nevertheless, these approaches are resource-intensive, generate results that are difficult to compare across jurisdictions, and measure less than the total burden of disease. By adopting more efficient methods, resources could be diverted instead to education of at-risk populations and new approaches to prevention. In this special issue of Zoonoses and Public Health, seven articles are presented that either evaluate traditional Lyme disease surveillance methods or explore alternatives that have the potential to be less costly, more reliable, and sustainable...
March 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29428491/knowledge-and-preventive-behaviors-towards-tick-borne-diseases-in-delaware
#16
Sangeeta Gupta, Paula Eggers, Ana Arana, Brianna Kresse, Kristen Rios, Leah Brown, Lydia Sampson, Mitchell Kploanyi
Delaware is among the top 10 states in the United States with the highest incidence for Lyme disease. The Delaware Division of Public Health (DPH) therefore has been working diligently to prevent and control tick-borne diseases through a variety of interventions including awareness campaigns and educational programs. To assess if tick-borne disease related information is reaching Delawareans through these programs, DPH in collaboration with Delaware State University administered an anonymous survey to 1755 participants in all three of Delaware counties during May 2017...
February 3, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29426591/surveillance-of-british-ticks-an-overview-of-species-records-host-associations-and-new-records-of-ixodes-ricinus-distribution
#17
Benjamin Cull, Maaike E Pietzsch, Kayleigh M Hansford, Emma L Gillingham, Jolyon M Medlock
Public Health England's passive Tick Surveillance Scheme (TSS) records the distribution, seasonality and host associations of ticks submitted from across the United Kingdom (UK), and helps to inform the UK government on emerging tick-borne disease risks. Here we summarise data collected through surveillance during 2010-2016, and compare with previous TSS data from 2005 to 2009, particularly in relation to the primary Lyme borreliosis vector Ixodes ricinus. 4173 records were submitted, constituting >14,000 ticks; 97% were endemic tick records (13,833 ticks of 11 species), with an additional 97 records of imported ticks (438 ticks of 17 species)...
February 3, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29425271/lyme-disease-testing-in-a-high-incidence-state-clinician-knowledge-and-patterns
#18
Joanna L Conant, Julia Powers, Gregory Sharp, Paul S Mead, Christina A Nelson
Objectives: Lyme disease (LD) incidence is increasing, but data suggest some clinicians are not fully aware of recommended procedures for ordering and interpreting diagnostic tests. The study objective was to assess clinicians' knowledge and practices regarding LD testing in a high-incidence region. Methods: We distributed surveys to 1,142 clinicians in the University of Vermont Medical Center region, of which 144 were completed (12.6% response rate). We also examined LD laboratory test results and logs of calls to laboratory customer service over a period of 2...
February 7, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29422448/predictive-value-of-borrelia-burgdorferi-igg-antibody-levels-in-patients-referred-to-a-tertiary-lyme-centre
#19
M Zwerink, T P Zomer, B van Kooten, G Blaauw, T van Bemmel, B C van Hees, Y M Vermeeren, G W Landman
A two-step testing strategy is recommended in serological testing for Lyme borreliosis; positive and indeterminate enzyme-linked immunosorbent assay (ELISA) results are confirmed with immunoblots. Several ELISAs quantify the concentration of antibodies tested, however, no recommendation exists for an upper cut-off value at which an IgG ELISA is sufficient and the immunoblot can be omitted. The study objective was to determine at which IgG antibody level an immunoblot does not have any additional predictive value compared to ELISA results...
December 24, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29421691/the-development-of-an-igg-avidity-western-blot-with-potential-to-differentiate-patients-with-active-lyme-borreliosis-from-those-with-past-infection
#20
Sally Mavin, Roger Evans, Thomas Cornulier, Alan S Bowman
OBJECTIVES: Current serological methods cannot distinguish active from past infection with Borrelia burgdorferi sensu lato. The aim of this study was to develop an IgG avidity Western blot and assess its potential to differentiate patients with early and late Lyme borreliosis (LB) i.e. active disease, from those infected in the past. METHODS: An IgG avidity Western blot was developed. Penalized linear discriminant analysis (PLDA) was employed to compare the Western blot/avidity Western blot profiles of an evaluation panel consisting of 75 sera from patients with early (n = 26) and late (n = 24) LB and past infection (n = 25)...
February 5, 2018: Journal of Microbiological Methods
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