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https://www.readbyqxmd.com/read/29674128/diagnostic-value-of-cerebrospinal-fluid-cxcl13-for-acute-lyme-neuroborreliosis-a-systemic-review-and-meta-analysis
#1
REVIEW
Tobias Armin Rupprecht, Kirsi Marjaana Manz, Volker Fingerle, Christian Lechner, Matthias Klein, Markus Pfirrmann, Uwe Koedel
OBJECTIVES: The utility of cerebrospinal fluid (CSF) CXCL13 for diagnosis of acute Lyme neuroborreliosis (LNB) has been debated and the test is not yet routinely performed. This study's aim was to evaluate its overall diagnostic accuracy through meta-analysis. METHODS: Electronic searches in PubMed MEDLINE and Web of Science were performed to identify relevant articles published before January 2018. A summary receiver operating characteristic curve and an optimal cut-off were estimated modeling multiple cut-offs...
April 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29673413/seven-cases-of-probable-endotoxin-poisoning-related-to-contaminated-glutathione-infusions
#2
T Johnstone, E Quinn, S Tobin, R Davis, Z Najjar, B Battye, L Gupta
We report seven cases of probable endotoxin poisoning linked to contaminated compounded glutathione. Five of the cases were using the infusions for treatment of Lyme disease highlighting the risks of using compounded sterile preparations for unapproved indications, especially if the quality of source products cannot be assured.
April 20, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29672671/adverse-events-associated-with-antibiotics-and-intravenous-therapies-for-post-lyme-disease-syndrome-in-a-commercially-insured-sample
#3
Kellie J Goodlet, Kathleen A Fairman
Background: Non-guideline endorsed post-treatment courses of antibiotics for post-Lyme disease syndrome (PLDS) have been linked to adverse patient outcomes, but these findings have yet to be validated in large systematic evaluations. Methods: A retrospective cohort analysis of medical and pharmacy claims derived from the Truven Health Market Scan® Commercial Claims and Encounters Database assessed 90-day incidence rates of adverse events (AEs) associated with PLDS treatments (PLDS-TX)...
April 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29671559/clinical-diagnosis-of-lyme-disease-frequently-misses-the-bull-s-eye
#4
Allen F Shaughnessy
No abstract text is available yet for this article.
April 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29671475/integrated-social-behavioral-and-ecological-risk-maps-to-prioritize-local-public-health-responses-to-lyme-disease
#5
Catherine Bouchard, Cécile Aenishaenslin, Erin E Rees, Jules K Koffi, Yann Pelcat, Marion Ripoche, François Milord, L Robbin Lindsay, Nicholas H Ogden, Patrick A Leighton
BACKGROUND: The risk of contracting Lyme disease (LD) can vary spatially because of spatial heterogeneity in risk factors such as social-behavior and exposure to ecological risk factors. Integrating these risk factors to inform decision-making should therefore increase the effectiveness of mitigation interventions. OBJECTIVES: The objective of this study was to develop an integrated social-behavioral and ecological risk-mapping approach to identify priority areas for LD interventions...
April 18, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29670860/relapsing-fevers-neglected-tick-borne-diseases
#6
REVIEW
Emilie Talagrand-Reboul, Pierre H Boyer, Sven Bergström, Laurence Vial, Nathalie Boulanger
Relapsing fever still remains a neglected disease and little is known on its reservoir, tick vector and physiopathology in the vertebrate host. The disease occurs in temperate as well as tropical countries. Relapsing fever borreliae are spirochaetes, members of the Borreliaceae family which also contain Lyme disease spirochaetes. They are mainly transmitted by Ornithodoros soft ticks, but some species are vectored by ixodid ticks. Traditionally a Borrelia species is associated with a specific vector in a particular geographical area...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29669751/hip-synovial-fluid-cell-counts-in-children-from-a-lyme-disease-endemic-area
#7
Arianna H Dart, Kenneth A Michelson, Paul L Aronson, Aris C Garro, Thomas J Lee, Kimberly M Glerum, Peter A Nigrovic, Mininder S Kocher, Richard G Bachur, Lise E Nigrovic
BACKGROUND: Patients with septic hip arthritis require surgical drainage, but they can be difficult to distinguish from patients with Lyme arthritis. The ability of synovial fluid white blood cell (WBC) counts to help discriminate between septic and Lyme arthritis of the hip has not been investigated. METHODS: We assembled a retrospective cohort of patients ≤21 years of age with hip monoarticular arthritis and a synovial fluid culture obtained who presented to 1 of 3 emergency departments located in Lyme disease endemic areas...
April 18, 2018: Pediatrics
https://www.readbyqxmd.com/read/29665403/lack-of-serological-evidence-for-lyme-like-borreliosis-in-brazil
#8
Stefan Vilges de Oliveira, Álvaro A Faccini-Martínez, Crispim Cerutti
No abstract text is available yet for this article.
April 14, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29662016/persistent-borrelia-infection-in-patients-with-ongoing-symptoms-of-lyme-disease
#9
Marianne J Middelveen, Eva Sapi, Jennie Burke, Katherine R Filush, Agustin Franco, Melissa C Fesler, Raphael B Stricker
INTRODUCTION: Lyme disease is a tickborne illness that generates controversy among medical providers and researchers. One of the key topics of debate is the existence of persistent infection with the Lyme spirochete, Borrelia burgdorferi , in patients who have been treated with recommended doses of antibiotics yet remain symptomatic. Persistent spirochetal infection despite antibiotic therapy has recently been demonstrated in non-human primates. We present evidence of persistent Borrelia infection despite antibiotic therapy in patients with ongoing Lyme disease symptoms...
April 14, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29661882/-in-vitro-antimicrobial-susceptibility-of-clinical-isolates-of-borrelia-miyamotoi
#10
Joris Koetsveld, Annemijn Manger, Dieuwertje Hoornstra, Ronald O Draga, Anneke Oei, Nadezhda M Kolyasnikova, Marina G Toporkova, Denis S Sarksyan, Alex Wagemakers, Alexander E Platonov, Joppe W Hovius
Objectives : Borrelia miyamotoi is an emerging relapsing fever (RF) Borrelia species that is described to cause human disease in regions where Lyme borreliosis is endemic. We have recently shown that B. miyamotoi tick isolates are resistant to amoxicillin in vitro, however, clinical isolates have not been studied. Therefore, our aim was to show antimicrobial susceptibility of recently obtained clinical isolates of B. miyamotoi Methods : A dilution series of various antibiotics was made in MKP-F media. Susceptibility of different clinical B...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29660558/multilocus-sequence-analysis-of-borrelia-burgdorferi-sensu-lato-isolates-from-western-siberia-russia-and-northern-mongolia
#11
Yuliya Sabitova, Nataliya Fomenko, Artem Tikunov, Oleg Stronin, Maxim Khasnatinov, Davaajav Abmed, Galina Danchinova, Irina Golovljova, Nina Tikunova
Lyme borreliosis (LB) is the most frequently recorded tick-transmitted disease in Eurasia. Tomsk Province, Western Siberia in Russia and Selenge Aimag in Northern Mongolia are leading regions in the LB incidence rate in these countries. Spirochaetes of the Borrelia burgdorferi sensu lato (s.l.) complex isolated from Ixodes ticks from Tomsk Province (n = 56) and Ixodes persulcatus ticks from Selenge Aimag (n = 5) were genetically characterized using Multi Locus Sequence Typing (MLST), analysis of the 5S23S rRNA intergenic spacer (IGS) amplicons, and p83/100 gene sequencing...
April 13, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29650513/lyme-disease-summary-of-nice-guidance
#12
Maria Cruickshank, Norma O'Flynn, Saul N Faust
No abstract text is available yet for this article.
April 12, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29649156/using-landscape-analysis-to-test-hypotheses-about-drivers-of-tick-abundance-and-infection-prevalence-with-borrelia-burgdorferi
#13
A Michelle Ferrell, R Jory Brinkerhoff
Patterns of vector-borne disease risk are changing globally in space and time and elevated disease risk of vector-borne infection can be driven by anthropogenic modification of the environment. Incidence of Lyme disease, caused by the bacterium Borrelia burgdorferi sensu stricto, has risen in a number of locations in North America and this increase may be driven by spatially or numerically expanding populations of the primary tick vector, Ixodes scapularis . We used a model selection approach to identify habitat fragmentation and land-use/land cover variables to test the hypothesis that the amount and configuration of forest cover at spatial scales relevant to deer, the primary hosts of adult ticks, would be the predominant determinants of tick abundance...
April 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29623212/first-report-of-lyme-disease-in-nepal
#14
Sher Bahadur Pun, Sumit Agrawal, Santoshananda Jha, Lila Nath Bhandari, Bimal Sharma Chalise, Abadhesh Mishra, Rajesh Shah
Introduction: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi and is widely reported in the USA, Central Europe, South East Asia and Latin America. Until recently, no scientific report regarding Lyme disease in Nepal had been published. Case presentation: A 32-year-old, previously healthy female visited the hospital with a history of joint pains, fatigue, neck stiffness, tingling sensation and headache. She was initially treated for typhoid fever, brucellosis and malaria, but did not show significant improvement...
March 2018: JMM Case Reports
https://www.readbyqxmd.com/read/29621350/infection-history-of-the-blood-meal-host-dictates-pathogenic-potential-of-the-lyme-disease-spirochete-within-the-feeding-tick-vector
#15
Bharti Bhatia, Chad Hillman, Valentina Carracoi, Britney N Cheff, Kit Tilly, Patricia A Rosa
Lyme disease in humans is caused by several genospecies of the Borrelia burgdorferi sensu lato (s.l.) complex of spirochetal bacteria, including B. burgdorferi, B. afzelii and B. garinii. These bacteria exist in nature as obligate parasites in an enzootic cycle between small vertebrate hosts and Ixodid tick vectors, with humans representing incidental hosts. During the natural enzootic cycle, infected ticks in endemic areas feed not only upon naïve hosts, but also upon seropositive infected hosts. In the current study, we considered this environmental parameter and assessed the impact of the immune status of the blood-meal host on the phenotype of the Lyme disease spirochete within the tick vector...
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29614977/diagnostic-behaviour-of-general-practitioners-when-suspecting-lyme-disease-a-database-study-from-2010-2015
#16
Esmée Botman, C Wim Ang, Johanna H K Joosten, Pauline Slottje, Johannes C van der Wouden, Otto R Maarsingh
BACKGROUND: Due to the raised public awareness of Lyme Borreliosis (LB), its increased incidence and the increased availability of serological tests, the demand for diagnostic testing on LB has increased. This may affect the diagnostic behaviour of general practitioners (GPs). Aim of our study was to describe GPs' diagnostic behaviour when suspecting LB. METHODS: In this descriptive study from January 2010 to June 2015, we used the anonymized electronic medical records of 56,996 patients registered in 12 general practices in Amsterdam, The Netherlands...
April 3, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29613895/infectious-myelopathies
#17
Marie F Grill
PURPOSE OF REVIEW: This article reviews bacterial, viral, fungal, and parasitic pathogens associated with myelopathy. Infectious myelopathies may be due to direct infection or parainfectious autoimmune-mediated mechanisms; this article focuses primarily on the former. RECENT FINDINGS: Some microorganisms exhibit neurotropism for the spinal cord (eg, enteroviruses such as poliovirus and flaviviruses such as West Nile virus), while others are more protean in neurologic manifestations (eg, herpesviruses such as varicella-zoster virus), and others are only rarely reported to cause myelopathy (eg, certain fungal and parasitic infections)...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29610317/plasticity-in-early-immune-evasion-strategies-of-a-bacterial-pathogen
#18
Quentin Bernard, Alexis A Smith, Xiuli Yang, Juraj Koci, Shelby D Foor, Sarah D Cramer, Xuran Zhuang, Jennifer E Dwyer, Yi-Pin Lin, Emmanuel F Mongodin, Adriana Marques, John M Leong, Juan Anguita, Utpal Pal
Borrelia burgdorferi is one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term survival of this bacterium are largely unknown. Here we report a unique innate immune evasion strategy of B. burgdorferi , orchestrated by a surface protein annotated as BBA57, through its modulation of multiple spirochete virulent determinants. BBA57 function is critical for early infection but largely redundant for later stages of spirochetal persistence, either in mammals or in ticks...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29610173/sternoclavicular-arthritis-as-a-clinical-presentation-for-lyme-disease
#19
Sriram Ramgopal, Margalit Rosenkranz, Andrew J Nowalk, Noel S Zuckerbraun
Lyme disease is caused by Borrelia burgdorferi and can lead to dermatologic, neurologic, cardiac, and musculoskeletal manifestations. The arthritis of Lyme disease is typically monoarticular, with the knee being most commonly involved. Lyme arthritis of small joints has not previously been well described. We report 3 children who presented with sternoclavicular joint swelling and who were found to have Lyme disease based on enzyme-linked immunosorbent assay and Western blot. This description of sternoclavicular Lyme arthritis highlights the importance of considering Lyme disease in the differential and diagnostic workup of new onset, small joint arthritis in patients presenting from or with travel to Lyme endemic regions...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29608590/cost-effectiveness-of-longer-term-versus-shorter-term-provision-of-antibiotics-in-patients-with-persistent-symptoms-attributed-to-lyme-disease
#20
Anneleen Berende, Lisette Nieuwenhuis, Hadewych J M Ter Hofstede, Fidel J Vos, Michiel L Vogelaar, Mirjam Tromp, Henriët van Middendorp, A Rogier T Donders, Andrea W M Evers, Bart Jan Kullberg, Eddy M M Adang
BACKGROUND: The treatment of persistent symptoms attributed to Lyme disease remains controversial. Recently, the PLEASE study did not demonstrate any additional clinical benefit of longer-term versus shorter-term antibiotic treatment. However, the economic impact of the antibiotic strategies has not been investigated. METHODS: This prospective economic evaluation, adhering a societal perspective, was performed alongside the PLEASE study, a multicenter, placebo-controlled, double-blind 1:1:1 randomized clinical trial in which all patients received open-label intravenous ceftriaxone for two weeks before the 12-week randomized blinded oral antibiotic regimen (doxycycline, clarithromycin plus hydroxychloroquine, or placebo)...
2018: PloS One
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