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https://www.readbyqxmd.com/read/28107743/high-sensitivity-four-layer-polymer-fiber-optic-evanescent-wave-sensor
#1
Xin Xin, Nianbing Zhong, Qiang Liao, Yanyan Cen, Ruohua Wu, Zhengkun Wang
We present a novel four-layer structure consisting of bottom, second, third, and surface layers in the sensing region, for a D-shaped step-index fiber-optic evanescent wave (FOEW) sensor. To reduce the background noise, the surface of the longitudinal section in the D-shaped region is coated with a light-absorbing film. We check the morphologies of the second and surface layers, examine the refractive indices (RIs) of the third and surface layers, and analyze the composition of the surface layer. We also investigate the effects of the thicknesses and RIs of the third and surface layers and the LA film on the light transmission and sensitivity of the FOEW sensors...
January 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28106378/cell-selective-apoptosis-induced-by-polymorphic-alteration-of-self-assembled-silica-nano-webs
#2
Meysam Keshavarz, Bo Tan, Krishnan Venkatakrishnan
The biocompatibility of silicon-based nanomaterial makes it suitable for biophysical and biomedical applications. However, the application of silicon-based nanomaterials has been mainly restricted to nanoparticles (NPs) as a potential drug carrier and the extracellular matrix (ECM) as a platform for cell adhesion and proliferation. Here, we introduced silica NPs self-assembled into a 3D nano-web architecture that was shown to inherit the therapeutic and proliferative attributes of both NPs and ECMs. The self-assembled silica nano-web (SNW) has, therefore, not only shown targeted drug-like behavior in HeLa cells without the use of bio-markers but also has shown ECM characteristics...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106368/programmable-shape-recovery-process-of-water-responsive-shape-memory-polyvinyl-alcohol-by-wettability-contrast-strategy
#3
Zhiqiang Fang, Yudi Kuang, Panpan Zhou, Siyi Ming, Penghui Zhu, Yu Liu, Honglong Ning, Gang Chen
Water-responsive shape memory polymers (SMPs) are desirable for biomedical applications, but their limited shape recovery process is problematic. Herein, we demonstrate a shape-memory polyvinyl alcohol (SM-PVA) with programmable multi-step shape recovery processes in water via a wettability contrast strategy. A hexamethyldisilazane (HMDS)-treated SiO2 nanoparticle layer with varying loading weights was rationally deposited onto the surface of SM-PVA, aiming to create surface-wettability contrast. The varying wettability led to different water adsorption behaviors of SM-PVA that could be well described by the pseudo-first-order kinetic model...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106200/bright-conjugated-polymer-nanoparticles-containing-a-biodegradable-shell-produced-at-high-yields-and-with-tuneable-optical-properties-by-a-scalable-microfluidic-device
#4
T F Abelha, T W Phillips, J H Bannock, A M Nightingale, C A Dreiss, E Kemal, L Urbano, J C deMello, M Green, L A Dailey
This study compares the performance of a microfluidic technique and a conventional bulk method to manufacture conjugated polymer nanoparticles (CPNs) embedded within a biodegradable poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) (PEG5K-PLGA55K) matrix. The influence of PEG5K-PLGA55K and conjugated polymers cyano-substituted poly(p-phenylene vinylene) (CN-PPV) and poly(9,9-dioctylfluorene-2,1,3-benzothiadiazole) (F8BT) on the physicochemical properties of the CPNs was also evaluated. Both techniques enabled CPN production with high end product yields (∼70-95%)...
January 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28105473/recent-applications-of-the-combination-of-mesoporous-silica-nanoparticles-with-nucleic-acids-development-of-bioresponsive-devices-carriers-and-sensors
#5
REVIEW
Rafael R Castillo, Alejandro Baeza, María Vallet-Regí
The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Such is the importance of these gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits of DNA and RNA. Currently, there could be found in the literature a practically intractable number of examples reporting the use of combination of nanoparticles with nucleic acids, so boundaries are demanded. Following this premise, this review will only cover the most recent and powerful strategies developed to exploit the possibilities of nucleic acids as biotechnological materials when in combination with mesoporous silica nanoparticles...
January 20, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28105392/in-vivo-long-term-biodistribution-excretion-and-toxicology-of-pegylated-transition-metal-dichalcogenides-ms2-m-mo-w-ti-nanosheets
#6
Jiali Hao, Guosheng Song, Teng Liu, Xuan Yi, Kai Yang, Liang Cheng, Zhuang Liu
With unique 2D structures and intriguing physicochemical properties, various types of transition metal dichalcogenides (TMDCs) have attracted much attention in many fields including nanomedicine. Hence, it is of great importance to carefully study the in vivo biodistribution, excretion, and toxicology profiles of different TMDCs, and hopefully to identify the most promising type of TMDCs with low toxicity and fast excretion for further biomedical applications. Herein, the in vivo behaviors of three representative TMDCs including molybdenum dichalcogenides (MoS2), tungsten dichalcogenides (WS2), and titanium dichalcogenides (TiS2) nanosheets are systematically investigated...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28105391/one-dimensional-tio2-nanotube-photocatalysts-for-solar-water-splitting
#7
REVIEW
Mingzheng Ge, Qingsong Li, Chunyan Cao, Jianying Huang, Shuhui Li, Songnan Zhang, Zhong Chen, Keqin Zhang, Salem S Al-Deyab, Yuekun Lai
Hydrogen production from water splitting by photo/photoelectron-catalytic process is a promising route to solve both fossil fuel depletion and environmental pollution at the same time. Titanium dioxide (TiO2) nanotubes have attracted much interest due to their large specific surface area and highly ordered structure, which has led to promising potential applications in photocatalytic degradation, photoreduction of CO2, water splitting, supercapacitors, dye-sensitized solar cells, lithium-ion batteries and biomedical devices...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28104900/extremozymes-a-potential-source-for-industrial-applications
#8
REVIEW
Kelly Dumorné, David Camacho Córdova, Marcia Astorga-Eló, Prabhaharan Renganathan
Extremophilic microorganisms have established a diversity of molecular strategies in order to survive in extreme conditions. Biocatalysts isolated by these organisms are termed extremozymes, possess extraordinary properties are salt allowance thermostability and cold adaptivity. Extremozymes are very resistant in extreme conditions due to their great solidity and they propose new opportunities for biocatalysis and biotransformations, also for the development of the economy and new line of research through their application...
January 20, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28104510/mechanochemically-synthesized-ag-based-nanohybrids-with-unprecedented-low-toxicity-in-biomedical-applications
#9
Rick A D Arancon, Alina M Balu, Antonio A Romero, Manuel Ojeda, Mercedes Gomez, Jordi Blanco, Jose L Domingo, Rafael Luque
A simple and innovative mechanochemical approach was employed to synthesize Ag-polysaccharide nanohybrid materials that were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized Ag nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SY5Y as compared to similarly reported Ag nanomaterials due to the stability and low release of Ag(+) and high biocompatibility of the nanohybrids.
January 16, 2017: Environmental Research
https://www.readbyqxmd.com/read/28103663/biological-photothermal-nanodots-based-on-self-assembly-of-peptide-porphyrin-conjugates-for-antitumor-therapy
#10
Qianli Zou, Manzar Abbas, Luyang Zhao, Shukun Li, Guizhi Shen, Xuehai Yan
Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote-controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of J-aggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots...
January 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28103580/biodegradable-and-biocompatible-high-elastic-chitosan-scaffold-is-cell-friendly-both-in-vitro-and-in-vivo
#11
Yichuan Pang, An Qin, Xianfeng Lin, Lin Yang, Qiang Wang, Zhengke Wang, Zhi Shan, Shengyun Li, Jiying Wang, Shunwu Fan, Qiaoling Hu
Biodegradable and biocompatible macromolecule chitosan has been favored for a variety of clinical applications. We reported herein the fabrication of a novel chitosan scaffold with high elasticity. This scaffold can be easily compressed and thus enable the insertion of such scaffold into surgical lesions during minimal invasive surgeries. In addition, this novel scaffold can restore its shape when released. We evidenced that this high elastic scaffold has better biocompatibility than traditional chitosan scaffold...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28101874/bioengineered-collagens
#12
Barbara Brodsky, John A M Ramshaw
There is a great deal of interest in obtaining recombinant collagen as an alternative source of material for biomedical applications and as an approach for obtaining basic structural and biological information. However, application of recombinant technology to collagen presents challenges, most notably the need for post-translational hydroxylation of prolines for triple-helix stability. Full length recombinant human collagens have been successfully expressed in cell lines, yeast, and several plant systems, while collagen fragments have been expressed in E...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28101802/cold-pcr-technologies-in-the-area-of-personalized-medicine-methodology-and-applications
#13
REVIEW
Florence Mauger, Alexandre How-Kit, Jörg Tost
Somatic mutations bear great promise for use as biomarkers for personalized medicine, but are often present only in low abundance in biological material and are therefore difficult to detect. Many assays for mutation analysis in cancer-related genes (hotspots) have been developed to improve diagnosis, prognosis, prediction of drug resistance, and monitoring of the response to treatment. Two major approaches have been developed: mutation-specific amplification methods and methods that enrich and detect mutations without prior knowledge on the exact location and identity of the mutation...
January 18, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28101538/recent-advances-in-engineering-microparticles-and-their-nascent-utilization-in-biomedical-delivery-and-diagnostic-applications
#14
REVIEW
Andrew Choi, Kyoung Duck Seo, Do Wan Kim, Bum Chang Kim, Dong Sung Kim
Complex microparticles (MPs) bearing unique characteristics such as well-tailored sizes, various morphologies, and multi-compartments have been attempted to be produced by many researchers in the past decades. However, a conventionally used method of fabricating MPs, emulsion polymerization, has a limitation in achieving the aforementioned characteristics and several approaches such as the microfluidics-assisted (droplet-based microfluidics and flow lithography-based microfluidics), electrohydrodynamics (EHD)-based, centrifugation-based, and template-based methods have been recently suggested to overcome this limitation...
January 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28101428/wide-field-and-highly-sensitive-angiography-based-on-optical-coherence-tomography-with-akinetic-swept-source
#15
Jingjiang Xu, Shaozhen Song, Wei Wei, Ruikang K Wang
Wide-field vascular visualization in bulk tissue that is of uneven surface is challenging due to the relatively short ranging distance and significant sensitivity fall-off for most current optical coherence tomography angiography (OCTA) systems. We report a long ranging and ultra-wide-field OCTA (UW-OCTA) system based on an akinetic swept laser. The narrow instantaneous linewidth of the swept source with its high phase stability, combined with high-speed detection in the system enable us to achieve long ranging (up to 46 mm) and almost negligible system sensitivity fall-off...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28098453/surface-engineered-multifunctional-eu-gd2o3-nanoplates-for-targeted-and-ph-responsive-drug-delivery-and-imaging-applications
#16
Arindam Saha, Subas Chandra Mohanta, Kashmiri Deka, Pritam Deb, Parukuttyamma Sujatha Devi
In this paper, we report the synthesis of surface-engineered multifunctional Eu:Gd2O3 triangular nanoplates with small size and uniform shape via a high-temperature solvothermal technique. Surface engineering has been performed by a one-step polyacrylate coating, followed by controlled conjugation chemistry. This creates the desired number of surface functional groups that can be used to attach folic acid as a targeting ligand on the nanoparticle surface. To specifically deliver the drug molecules in the nucleus, the folate density on the nanoparticle surface has been kept low...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28098320/versatile-tissue-lasers-based-on-high-q-fabry-p%C3%A3-rot-microcavities
#17
Yu-Cheng Chen, Qiushu Chen, Tingting Zhang, Wenjie Wang, Xudong Fan
Biolasers are an emerging technology for next generation biochemical detection and clinical applications. Progress has recently been made to achieve lasing from biomolecules and single living cells. Tissues, which consist of cells embedded in an extracellular matrix, mimic more closely the actual complex biological environment in a living body and therefore are of more practical significance. Here, we developed a highly versatile tissue laser platform, in which tissues stained with fluorophores are sandwiched in a high-Q Fabry-Pérot microcavity...
January 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28098300/exploration-of-new-ferromagnetic-semiconducting-and-biocompatible-nb3x8-x-cl-br-or-i-monolayers-with-considerable-visible-and-infrared-light-absorption
#18
Junke Jiang, Qiuhua Liang, Ruishen Meng, Qun Yang, Chunjian Tan, Xiang Sun, Xianping Chen
Ferromagnetic character and biocompatible properties have become key factors for developing next-generation spintronic devices and show potential in biomedical applications. Unfortunately, the Mn-containing monolayer is not biocompatible though it has been extensively studied, and the Cr-containing monolayer is not environmental friendly, although these monolayers are ferromagnetic. Herein, we systematically investigated new types of 2D ferromagnetic monolayers Nb3X8 (X = Cl, Br or I) by means of first principles calculations together with mean field approximation based on the classical Heisenberg model...
January 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28098265/depth-selective-photothermal-ir-spectroscopy-of-skin-potential-application-for-non-invasive-glucose-measurement
#19
Otto Hertzberg, Alexander Bauer, Arne Küderle, Miguel A Pleitez, Werner Mäntele
An infrared spectroscopic technique is described that employs a mid-IR broadband (980-1245 cm(-1)) tunable quantum cascade laser (QCL) to produce a pump beam, and a detection method based on photothermal deflection, enhanced by total internal reflection. The IR spectra thus obtained are depth-dependent by modulating the pump beam with different frequencies between 10 Hz and 500 Hz. A model system consisting of glucose and a polymer film is used to demonstrate the depth selectivity of this technique. We also apply this photothermal depth profiling method to record in vivo IR spectra of the human epidermis at different depths...
January 18, 2017: Analyst
https://www.readbyqxmd.com/read/28098208/high-efficiency-hydrodynamic-dna-fragmentation-in-a-bubbling-system
#20
Lanhui Li, Mingliang Jin, Chenglong Sun, Xiaoxue Wang, Shuting Xie, Guofu Zhou, Albert van den Berg, Jan C T Eijkel, Lingling Shui
DNA fragmentation down to a precise fragment size is important for biomedical applications, disease determination, gene therapy and shotgun sequencing. In this work, a cheap, easy to operate and high efficiency DNA fragmentation method is demonstrated based on hydrodynamic shearing in a bubbling system. We expect that hydrodynamic forces generated during the bubbling process shear the DNA molecules, extending and breaking them at the points where shearing forces are larger than the strength of the phosphate backbone...
January 18, 2017: Scientific Reports
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