keyword
MENU ▼
Read by QxMD icon Read
search

Biomedical applications

keyword
https://www.readbyqxmd.com/read/28821875/convenient-and-effective-icgylation-of-magnetic-nanoparticles-for-biomedical-applications
#1
Hye Sun Park, Jongwoo Kim, Mi Young Cho, Hyunseung Lee, Sang Hwan Nam, Yung Doug Suh, Kwan Soo Hong
Nanoprobes used for biomedical applications usually require surface modifications with amphiphilic surfactants or inorganic coating materials to enhance their biocompatibility. We proposed a facile synthetic approach for the phase transfer of hydrophobic magnetic nanoparticles by the direct adherence of fluorescent probes, without any chemical modifications, for use as a magnetic resonance (MR)/near-infrared (NIR) fluorescence bimodal imaging contrast agent. Indocyanine green (ICG) was used not only as an optical component for NIR imaging, but also as a surfactant for phase transfer with no superfluous moiety: we therefore called the process "ICGylation"...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821153/combination-of-microsized-mineral-particles-and-rosin-as-a-basis-for-converting-cellulosic-fibers-into-sticky-superhydrophobic-paper
#2
Xiaoyan Yu, Peiwen Bian, Yang Xue, Xueren Qian, Haipeng Yu, Wenshuai Chen, Xiaohai Hu, Peng Wang, Dong Wu, Qinghui Duan, Limei Li, Jing Shen, Yonghao Ni
The unique features of cellulosic paper including flexibility, biodegradability, and low cost enables it as a versatile, sustainable biomaterial for promising applications. In the paper industry, microsized mineral particles are widely used in the production of printing/writing paper grades, while rosin derived from trees is the earliest internal sizing agent for paper hydrophobication. On the basis of existing commercial practices associated with the use of mineral particles and rosin in paper production, we present a process concept of converting cellulosic fibers (paper-grade pulp) into "sticky" superhydrophobic paper involving the use of microsized mineral particles and rosin (a tree-derived natural product, mainly a mixture of resin acids, especially abietic acid with chemical formula of C19H29COOH)...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821150/functionalized-alginate-with-liquid-like-behaviors-and-its-application-in-wet-spinning
#3
Zhen Sang, Wenqian Zhang, Zhiyuan Zhou, Huakang Fu, Yeqiang Tan, Kunyan Sui, Yanzhi Xia
Alginate is a kind of marine-derived plant polysaccharide with useful properties including inherent flame-retardancy and biocompatibility, yet poor flowability and low processing efficiency induced by high viscosity impede its further industrial applications. In this study, PEG-substituted tertiary amines were adapted to functionalize alginate with different molecular weight via acid-base reaction to improve the flowability. Based on alginate with low molecular weight, alginate fluids exhibited excellent flowability at room temperature in the absence of solvent...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821140/the-potential-of-cashew-gum-functionalization-as-building-blocks-for-layer-by-layer-films
#4
Álvaro J Leite, Rui R Costa, Ana M S Costa, Jeanny S Maciel, José F G Costa, Regina C M de Paula, João F Mano
Cashew gum (CG), an exudate polysaccharide from Anacardium occidentale trees, was carboxymethylated (CGCm) and oxidized (CGO). These derivatives were characterized by FTIR and zeta potential measurements confirming the success of carboxymethylation and oxidation reactions. Nanostructured multilayered films were then produced through layer-by-layer (LbL) assembly in conjugation with chitosan via electrostatic interactions or Schiff bases covalent bonds. The films were analyzed by QCM-D and AFM. CG functionalization increased the film thickness, with the highest thickness being achieved for the lowest oxidation degree...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821051/a-novel-self-assembly-lentinan-tetraphenylethylene%C3%A2-composite-with-strong-blue%C3%A2-fluorescence-in-water-and-its-properties
#5
Mengxia Li, Pan Chen, Min Xu, Xiaojuan Xu
We report a unique self-assembly of lentinan, a triple helical β-(1→3)-glucan (t-LNT), in water. By molecular dynamics simulation, it was found that t-LNT aggregated preferentially along the chain direction to form long chains, accompanied by side-direction linkage to form branches. Transmission electron microscopy images demonstrated that t-LNT formed dendrite-like fibers, which further formed fishnet-like porous/mesoporous aggregates with increasing concentration. The meshes in the fishnet were ascribed to the intersection of branches...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820962/wanted-alive-finding-bacteria-in-your-food
#6
Akira Kawamura
In this issue of Cell Chemical Biology, Pezacki and co-workers (Sherratt et al., 2017) report a simple method to metabolically label viable bacteria, which can be used to detect and capture foodborne pathogens. The method may also find many other applications because it can be used to recover live cells, pathogens and non-pathogens, from various biomedical and environmental samples.
August 17, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28820488/phase-behaviour-and-miscibility-studies-of-collagen-silk-fibroin-macromolecular-system-in-dilute-solutions-and-solid-state
#7
Ima Ghaeli, Mariana A de Moraes, Marisa M Beppu, Katarzyna Lewandowska, Alina Sionkowska, Frederico Ferreira-da-Silva, Maria P Ferraz, Fernando J Monteiro
Miscibility is an important issue in biopolymer blends for analysis of the behavior of polymer pairs through the detection of phase separation and improvement of the mechanical and physical properties of the blend. This study presents the formulation of a stable and one-phase mixture of collagen and regenerated silk fibroin (RSF), with the highest miscibility ratio between these two macromolecules, through inducing electrostatic interactions, using salt ions. For this aim, a ternary phase diagram was experimentally built for the mixtures, based on observations of phase behavior of blend solutions with various ratios...
August 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28820479/esterification-mechanism-of-bagasse-modified-with-glutaric-anhydride-in-1-allyl-3-methylimidazolium-chloride
#8
Huihui Wang, Wei Chen, Xueqin Zhang, Chuanfu Liu, Runcang Sun
The esterification of bagasse with glutaric anhydride could increase surface adhesion compatibility and the surface of derived polymers has the potential of immobilizing peptides or proteins for biomedical application. Due to its complicated components, the esterification mechanism of bagasse esterified with glutaric anhydride in ionic liquids has not been studied. In this paper, the homogenous esterification of bagasse with glutaric anhydride was comparatively investigated with the isolated cellulose, hemicelluloses, and lignin in 1-allyl-3-methylimidazolium chloride (AmimCl) to reveal the reaction mechanism...
August 18, 2017: Materials
https://www.readbyqxmd.com/read/28820244/rapid-and-quantitative-measurement-of-single-quantum-dots-in-a-sheath-flow-cuvette
#9
Shuo Wang, Lihong Li, Shenghao Jin, Weifeng Li, Wei Hang, Xiaomei Yan
Semiconducting quantum dots (QDs) are finding a wide range of biomedical applications due to their intense fluorescence brightness and long-term photostability. Here, we report precise quantification of the fluorescence intensity of single QDs on a laboratory-built high-sensitivity flow cytometer (HSFCM). The nearly uniform illumination of the particles at the intense portions of the radiation field resulted in narrowly distributed signals with high signal-to-noise ratios. By analyzing thousands of QDs individually in as little time as 1 min, intrinsic polydispersity was quickly revealed in a statistically robust manner...
August 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28820072/structural-design-and-physicochemical-foundations-of-hydrogels-for-biomedical-and-pharmaceutical-applications
#10
Qingyong Li, Wen Li, Jie Xu, Zhengxiang Ning, Jiaoyan Ren, Wenzhen Liao
Biomedical research, known as medical research, is conducive to support and promote the development of knowledge in the field of medicine. Hydrogels have been extensively used in many biomedical fields due to theirs highly absorbent and flexible properties. The smart hydrogels, especially, can respond to a broad range of external stimuli such as temperature, pH value, light, electric and magnetic fields. With excellent biocompatibility, tunable rheology, mechanical properties, porosity, and hydrated molecular structure, hydrogels are considered as promising candidate for simulating local tissue microenvironment...
August 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28819645/3d-imaging-of-optically-cleared-tissue-using-a-simplified-clarity-method-and-on-chip-microscopy
#11
Yibo Zhang, Yoonjung Shin, Kevin Sung, Sam Yang, Harrison Chen, Hongda Wang, Da Teng, Yair Rivenson, Rajan P Kulkarni, Aydogan Ozcan
High-throughput sectioning and optical imaging of tissue samples using traditional immunohistochemical techniques can be costly and inaccessible in resource-limited areas. We demonstrate three-dimensional (3D) imaging and phenotyping in optically transparent tissue using lens-free holographic on-chip microscopy as a low-cost, simple, and high-throughput alternative to conventional approaches. The tissue sample is passively cleared using a simplified CLARITY method and stained using 3,3'-diaminobenzidine to target cells of interest, enabling bright-field optical imaging and 3D sectioning of thick samples...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28819351/a-systematic-analysis-of-term-reuse-and-term-overlap-across-biomedical-ontologies
#12
Maulik R Kamdar, Tania Tudorache, Mark A Musen
Reusing ontologies and their terms is a principle and best practice that most ontology development methodologies strongly encourage. Reuse comes with the promise to support the semantic interoperability and to reduce engineering costs. In this paper, we present a descriptive study of the current extent of term reuse and overlap among biomedical ontologies. We use the corpus of biomedical ontologies stored in the BioPortal repository, and analyze different types of reuse and overlap constructs. While we find an approximate term overlap between 25-31%, the term reuse is only <9%, with most ontologies reusing fewer than 5% of their terms from a small set of popular ontologies...
2017: Semantic Web
https://www.readbyqxmd.com/read/28819250/oblique-scanning-laser-microscopy-for-simultaneously-volumetric-structural-and-molecular-imaging-using-only-one-raster-scan
#13
Lei Zhang, Amalia Capilla, Weiye Song, Gustavo Mostoslavsky, Ji Yi
Multi-modal three dimensional (3D) optical imaging combining both structural sensitivity and molecular specificity is highly desirable in biomedical research. In this paper, we present a method termed oblique scanning laser microscopy (OSLM) to combine optical coherence tomography (OCT), for simultaneously volumetric structural and molecular imaging with cellular resolution in all three dimensions. Conventional 3D laser scanning fluorescence microscopy requires repeated optical sectioning to create z-stacks in depth...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818897/draft-genome-sequence-of-bacillus-sp-strain-k2i17-isolated-from-the-rhizosphere-of-deschampsia-antarctica-desv
#14
Alequis Pavón, Paz Orellana, Lorena Salazar, Sandra Céspedes, Laura Muiño, Ana Gutiérrez, Daniel Castillo, Gino Corsini
We present here the draft genome sequence of Bacillus sp. strain K2I17, which was isolated from the rhizosphere of Deschampsia antarctica Desv. The genomic sequence contained 6,113,341 bp. This genome provides insights into the possible new biomedical and biotechnical applications of this specific Antarctic bacterium.
August 17, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28818724/enzyme-sensitive-smart-inulin-dehydropeptide-conjugate-self-assembles-into-nanostructures-useful-for-targeted-delivery-of-ornidazole
#15
Kriti Shivhare, Charu Garg, Ayushi Priyam, Alka Gupta, Ashwani Kumar Sharma, Pradeep Kumar
Molecular self-assembly of biodegradable amphiphilic polymers allows rational design of biocompatible nanomaterials for drug delivery. Use of substituted polysaccharides for such applications offers the ease of design and synthesis, and provides higher biofunctionality and biocompatibility to nanomaterials. The present work focuses on the synthesis, characterization and potential biomedical applications of self-assembled polysaccharide-based materials. We demonstrated that the synthesized amphiphilic inulin self-assembled in aqueous medium into nanostructures with average size in the range of 146-486nm and encapsulated hydrophobic therapeutic molecule, ornidazole...
August 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28818688/anodization-of-magnesium-for-biomedical-applications-processing-characterization-degradation-and-cytocompatibility
#16
Aaron F Cipriano, Jiajia Lin, Christopher Miller, Alan Lin, Mayra C Cortez Alcaraz, Pedro Soria, Huinan Liu
This article reports anodization of Mg in KOH electrolyte and the associated surface, degradation, and biological properties for bioresorbable implant applications. The preparation procedures for electrodes and anodization setup significantly enhanced reproducibility of samples. The results of anodization performed at the applied potentials of 1.8, 1.9, or 2.0 V showed that the sample anodized at 1.9 V and annealed, referred to as the 1.9 AA sample, had homogenous surface microstructure and elemental composition, and a reduction in corrosion current density in the electrochemical testing...
August 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28818036/ecccl-parallelized-gpu-implementation-of-ensemble-classifier-chains
#17
Mona Riemenschneider, Alexander Herbst, Ari Rasch, Sergei Gorlatch, Dominik Heider
BACKGROUND: Multi-label classification has recently gained great attention in diverse fields of research, e.g., in biomedical application such as protein function prediction or drug resistance testing in HIV. In this context, the concept of Classifier Chains has been shown to improve prediction accuracy, especially when applied as Ensemble Classifier Chains. However, these techniques lack computational efficiency when applied on large amounts of data, e.g., derived from next-generation sequencing experiments...
August 17, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28817983/the-use-of-soft-robotics-in-cardiovascular-therapy
#18
Isaac Wamala, Ellen T Roche, Frank A Pigula
Robots have been employed in cardiovascular therapy as surgical tools and for automation of hospital systems. Soft robots are a new kind of robot made of soft deformable materials. They are uniquely suited for biomedical applications because they are inherently less likely to injure body tissues and more likely to adapt to biological environments. Awareness of the soft robotic systems under development will help promote clinician involvement in their successful translation for therapeutic use. Areas Covered: The soft robotic systems, across the size scale from nano to macro, that have shown the most promise for clinical application in cardiovascular therapy because they represent the most mature technology and also they offer solutions where a clear therapeutic need still exists...
August 18, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28817259/sub-20-nm-stable-micelles-based-on-a-mixture-of-coiled-coils-a-platform-for-controlled-ligand-presentation
#19
JooChuan Ang, Dan Ma, Benson Thomas Jung, Sinan Keten, Ting Xu
Ligand-functionalized, multivalent nanoparticles have been extensively studied for biomedical applications from imaging agents to drug delivery vehicles. However, the ligand cluster size is usually heterogeneous and the local valency is ill-defined. Here, we present a mixed micelle platform hierarchically self-assembled from a mixture of two amphiphilic 3-helix and 4-helix peptide-PEG-lipid hybrid conjugates. We demonstrate that the local multivalent ligand cluster size on the micelle surface can be controlled based on the coiled-coil oligomeric state...
August 17, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28817084/permalloy-based-thin-film-structures-magnetic-properties-and-the-giant-magnetoimpedance-effect-in-the-temperature-range-important-for-biomedical-applications
#20
Anna A Chlenova, Alexey A Moiseev, Mikhail S Derevyanko, Aleksandr V Semirov, Vladimir N Lepalovsky, Galina V Kurlyandskaya
Permalloy-based thin film structures are excellent materials for sensor applications. Temperature dependencies of the magnetic properties and giant magneto-impedance (GMI) were studied for Fe19Ni81-based multilayered structures obtained by the ion-plasma sputtering technique. Selected temperature interval of 25 °C to 50 °C corresponds to the temperature range of functionality of many devices, including magnetic biosensors. A (Cu/FeNi)₅/Cu/(Cu/FeNi)₅ multilayered structure with well-defined traverse magnetic anisotropy showed an increase in the GMI ratio for the total impedance and its real part with temperature increased...
August 17, 2017: Sensors
keyword
keyword
15389
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"