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Biomedical applications

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https://www.readbyqxmd.com/read/29243763/i2-catalyzed-access-of-spiro-indoline-3-4-pyridine-appended-amine-dyad-new-on-off-chemosensors-for-cu2-and-imaging-in-living-cells
#1
Animesh Mondal, Barnali Naskar, Sanchita Goswami, Chandraday Prodhan, Keya Chaudhuri, Chhanda Mukhopadhyay
An easy access to an amine-appended spiro[indoline-3,4'-pyridine] ON-OFF chemosensor by a one-pot four-component reaction using commercially available and an environmentally benign catalytic amount of molecular I2 (10 mol%) in aqueous ethanol at ambient temperature is described. The generated system could be utilized for the selective detection of Cu2+ as it demonstrated a colorimetric naked eye change along with an ON-OFF fluorescence response towards Cu2+ at physiological pH. The sensors exhibited high selectivity for Cu2+ over other common cations with detection limit in the range of 10-7 (M)...
December 15, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29243414/biomedical-device-innovation-methodology-applications-in-biophotonics
#2
Daniel M Beswick, Arjun Kaushik, Dylan Beinart, Sarah McGarry, Ming Khoon Yew, Brendan F Kennedy, Peter Luke Santa Maria
The process of medical device innovation involves an iterative method that focuses on designing innovative, device-oriented solutions that address unmet clinical needs. This process has been applied to the field of biophotonics with many notable successes. Device innovation begins with identifying an unmet clinical need and evaluating this need through a variety of lenses, including currently existing solutions for the need, stakeholders who are interested in the need, and the market that will support an innovative solution...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29242877/unravelling-the-mechanisms-that-determine-the-uptake-and-metabolism-of-magnetic-single-and-multicore-nanoparticles-in-a-xenopus-laevis-model
#3
M Marín-Barba, H Gavilán, L Gutiérrez, E Lozano-Velasco, I Rodríguez-Ramiro, G N Wheeler, C J Morris, M P Morales, A Ruiz
Multicore superparamagnetic nanoparticles have been proposed as ideal tools for some biomedical applications because of their high magnetic moment per particle, high specific surface area and long term colloidal stability. Through controlled aggregation and packing of magnetic cores it is possible to obtain not only single-core but also multicore and hollow spheres with internal voids. In this work, we compare toxicological properties of single and multicore nanoparticles. Both types of particles showed moderate in vitro toxicity (MTT assay) tested in Hep G2 (human hepatocellular carcinoma) and Caco-2 (human colorectal adenocarcinoma) cells...
December 15, 2017: Nanoscale
https://www.readbyqxmd.com/read/29242714/compressive-hyperspectral-time-resolved-wide-field-fluorescence-lifetime-imaging
#4
Qi Pian, Ruoyang Yao, Nattawut Sinsuebphon, Xavier Intes
Spectrally resolved fluorescence lifetime imaging1-3 and spatial multiplexing1,4,5 have offered information content and collection-efficiency boosts in microscopy, but efficient implementations for macroscopic applications are still lacking. An imaging platform based on time-resolved structured light and hyperspectral single-pixel detection has been developed to perform quantitative macroscopic fluorescence lifetime imaging (MFLI) over a large field of view (FOV) and multiple spectral bands simultaneously. The system makes use of three digital micromirror device (DMD)-based spatial light modulators (SLMs) to generate spatial optical bases and reconstruct N by N images over 16 spectral channels with a time-resolved capability (~40 ps temporal resolution) using fewer than N2 optical measurements...
2017: Nature Photonics
https://www.readbyqxmd.com/read/29242568/automatic-multiple-zebrafish-larvae-tracking-in-unconstrained-microscopic-video-conditions
#5
Xiaoying Wang, Eva Cheng, Ian S Burnett, Yushi Huang, Donald Wlodkowic
The accurate tracking of zebrafish larvae movement is fundamental to research in many biomedical, pharmaceutical, and behavioral science applications. However, the locomotive characteristics of zebrafish larvae are significantly different from adult zebrafish, where existing adult zebrafish tracking systems cannot reliably track zebrafish larvae. Further, the far smaller size differentiation between larvae and the container render the detection of water impurities inevitable, which further affects the tracking of zebrafish larvae or require very strict video imaging conditions that typically result in unreliable tracking results for realistic experimental conditions...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241007/sulfur-doped-laser-induced-porous-graphene-derived-from-polysulfone-class-polymers-and-membranes
#6
Swatantra Pratap Singh, Yilun Li, Jibo Zhang, James M Tour, Christopher J Arnusch
Graphene based materials have profoundly impacted research in nanotechnology and this has significantly advanced biomedical, electronics, energy, and environmental applications. Laser-induced graphene (LIG) is made photothermally and has enabled a rapid route for graphene layers on polyimide surfaces. However, polysulfone (PSU), polyethersulfone (PES), and polyphenylsulfone (PPSU) are highly used in numerous applications including medical, energy and water treatment and they are critical components of polymer membranes...
December 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/29241002/the-future-of-multiplexed-eukaryotic-genome-engineering
#7
David B Thompson, Soufiane Aboulhouda, Eriona Hysolli, Cory J Smith, Stan Wang, Oscar Castanon, George M Church
Multiplex genome editing is the simultaneous introduction of multiple distinct modifications to a given genome. Though in its infancy, maturation of this field will facilitate powerful new biomedical research approaches, and will enable a host of far-reaching biological engineering applications, including new therapeutic modalities and industrial applications, as well as 'genome writing' and de-extinction efforts. In this perspective, we focus on multiplex editing of large eukaryotic genomes. We describe the current state of multiplexed genome editing, the current limits of our ability to multiplex edits, and provide perspective on the many applications that fully-realized multiplex editing technologies would enable in higher eukaryotic genomes...
December 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29240559/fluorescence-detection-enumeration-and-characterization-of-single-circulating-cells-in-vivo-technology-applications-and-future-prospects
#8
Carolin Hartmann, Roshani Patil, Charles P Lin, Mark Niedre
There are many diseases and biological processes that involve circulating cells in the bloodstream, such as cancer metastasis, immunology, reproductive medicine, and stem cell therapies. This has driven significant interest in new technologies for the study of circulating cells in small animal research models and clinically. Most currently used methods require drawing and enriching blood samples from the body, but these suffer from a number of limitations. In contrast, 'in vivo flow cytometry' (IVFC) refers to set of technologies that allow study of cells directly in the bloodstream of the organism in vivo...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29240087/simulation-of-raman-scattering-including-detector-parameters-and-sampling-volume
#9
Ilya Krasnikov, Alexey Seteikin, Ann-Kathrin Kniggendorf, Merve Meinhardt-Wollweber, Bernhard Roth
Raman spectroscopy can be employed to measure the chemical composition of a sample, which can in turn be used to extract biological information. The aim of this paper is to introduce an efficient simulation technique for Raman spectroscopy in turbid (scattering) media taking into account relevant detector parameters and the sampling volume. We simulate the process of photon motion in turbid media by means of the Monte Carlo (MC) method. The numerical simulation of Raman scattering consists of two stages: calculation of the photon fluence at each point of the medium and subsequent generation of the corresponding amount of Raman photons at each point...
December 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29239240/applications-of-mid-infrared-spectroscopy-in-the-clinical-laboratory-setting
#10
Sander De Bruyne, Marijn M Speeckaert, Joris R Delanghe
Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool. Therefore, it has many potential applications in different fields of clinical laboratory science. Although considerable technological progress has been made to promote biomedical applications of this powerful analytical technique, most clinical laboratory analyses are based on spectroscopic measurements in the visible or ultraviolet (UV) spectrum and the potential role of FTIR spectroscopy still remains unexplored...
December 14, 2017: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29238438/aqueous-heterogeneous-parahydrogen-induced-15n-polarization
#11
Liana B Bales, Kirill V Kovtunov, Danila A Barskiy, Roman V Shchepin, Aaron M Coffey, Larisa M Kovtunova, Andrey V Bukhtiyarov, Matthew A Feldman, Valerii I Bukhtiyarov, Eduard Y Chekmenev, Igor V Koptyug, Boyd M Goodson
The successful transfer of parahydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analog of choline. As a result, 15N polarization enhancements of over two orders of magnitude were achieved for the 15N-ethyl trimethyl ammonium ion product in deuterated water at elevated temperatures...
July 20, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/29238115/high-spatial-sampling-light-guide-snapshot-spectrometer
#12
Ye Wang, Michal E Pawlowski, Tomasz S Tkaczyk
A prototype fiber-based imaging spectrometer was developed to provide snapshot hyperspectral imaging tuned for biomedical applications. The system is designed for imaging in the visible spectral range from 400 to 700 nm for compatibility with molecular imaging applications as well as satellite and remote sensing. An 81 × 96 pixel spatial sampling density is achieved by using a custom-made fiber-optic bundle. The design considerations and fabrication aspects of the fiber bundle and imaging spectrometer are described in detail...
2017: Optical Engineering: the Journal of the Society of Photo-optical Instrumentation Engineers
https://www.readbyqxmd.com/read/29236781/chitosan-coating-as-an-antibacterial-surface-for-biomedical-applications
#13
Mélanie D'Almeida, Nina Attik, Julien Amalric, Céline Brunon, François Renaud, Hazem Abouelleil, Bérangère Toury, Brigitte Grosgogeat
BACKGROUND AND OBJECTIVES: A current public health issue is preventing post-surgical complications by designing antibacterial implants. To achieve this goal, in this study we evaluated the antibacterial activity of an animal-free chitosan grafted onto a titanium alloy. METHODS: Animal-free chitosan binding on the substrate was performed by covalent link via a two-step process using TriEthoxySilylPropyl Succinic Anhydride (TESPSA) as the coupling agent. All grafting steps were studied and validated by means of X-ray Photoelectron Spectroscopy (XPS), Time-of-Flight secondary ion mass spectrometry (ToF-SIMS) analyses and Dynamic-mode Secondary Ion Mass Spectrometry (DSIMS)...
2017: PloS One
https://www.readbyqxmd.com/read/29236688/evolution-of-a-designed-protein-assembly-encapsulating-its-own-rna-genome
#14
Gabriel L Butterfield, Marc J Lajoie, Heather H Gustafson, Drew L Sellers, Una Nattermann, Daniel Ellis, Jacob B Bale, Sharon Ke, Garreck H Lenz, Angelica Yehdego, Rashmi Ravichandran, Suzie H Pun, Neil P King, David Baker
The challenges of evolution in a complex biochemical environment, coupling genotype to phenotype and protecting the genetic material, are solved elegantly in biological systems by the encapsulation of nucleic acids. In the simplest examples, viruses use capsids to surround their genomes. Although these naturally occurring systems have been modified to change their tropism and to display proteins or peptides, billions of years of evolution have favoured efficiency at the expense of modularity, making viral capsids difficult to engineer...
December 13, 2017: Nature
https://www.readbyqxmd.com/read/29236481/exploring-the-nanotoxicology-of-mos2-a-study-on-the-interaction-of-mos2-nanoflake-and-k-channels
#15
Zonglin Gu, Leigh D Plant, Xuanyu Meng, Jose Manuel Perez-Aguilar, Zegao Wang, Mingdong Dong, Diomedes E Logothetis, Ruhong Zhou
Molybdenum disulfide (MoS2) nanomaterial has recently found various applications in the biomedical field mainly due to its outstanding physicochemical properties. However, little is known about its interactions with biological systems at the atomic level, which intimately relates to the biocompatibility of the material. To provide insights into the effects of MoS2 in biological entities, we investigated the interactions of MoS2 with proteins from a functionally important membrane family, the ubiquitous potassium (K+) channels...
December 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/29236477/plasma-assisted-large-scale-nanoassembly-of-metal-insulator-bioplasmonic-mushrooms
#16
Nikhil Bhalla, Shivani Sathish, Casey James Galvin, Robert Anthony Campbell, Abhishek Sinha, Amy Q Shen
Large-scale plasmonic substrates consisting of metal-insulator nanostructures coated with a bio-recognition layer can be exploited for enhanced label-free sensing, by utilizing the principle of localized surface plasmon resonance (LSPR). Most often the uniformity and thickness of the bio-recognition layer determines the sensitivity of plasmonic resonances as the inherent LSPR sensitivity of nanomaterials is limited to 10-20 nm from the surface. However, due to time-consuming nanofabrication processes, there is limited work on both the development of large-scale plasmonic materials, and the subsequent surface functionalizing with bio-recognition layers...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29236059/the-toxicity-of-nanoparticles-depends-on-multiple-molecular-and-physicochemical-mechanisms
#17
REVIEW
Yue-Wern Huang, Melissa Cambre, Han-Jung Lee
Nanotechnology is an emerging discipline that studies matters at the nanoscale level. Eventually, the goal is to manipulate matters at the atomic level to serve mankind. One growing area in nanotechnology is biomedical applications, which involve disease management and the discovery of basic biological principles. In this review, we discuss characteristics of nanomaterials, with an emphasis on transition metal oxide nanoparticles that influence cytotoxicity. Identification of those properties may lead to the design of more efficient and safer nanosized products for various industrial purposes and provide guidance for assessment of human and environmental health risk...
December 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29235844/injectable-and-degradable-ph-responsive-hydrogel-via-spontaneous-amino-yne-click-reaction
#18
Jiachang Huang, Xulin Jiang
Injectable hydrogels have attracted increasing attentions in tissue regeneration and local drug delivery applications. Current click reactions for preparing injectable hydrogel often require a photoinitiator or catalyst, which may be toxic and may involve complex synthesis of precursors. Here we report a facile and inexpensive method to prepare injectable and degradable hydrogels via spontaneous amino-yne click reaction without using any initiator or catalyst under physiological conditions based on telechelic electron-deficient dipropiolate ester of polyethylene glycol and water-soluble commercially available carboxymethyl chitosan...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235842/mussel-inspired-synthesis-of-nir-responsive-and-biocompatible-ag-graphene-2d-nano-agents-for-versatile-bacterial-disinfections
#19
Xin Fan, Fan Yang, Chuanxiong Nie, Ye Yang, Haifeng Ji, Chao He, Chong Cheng, Changsheng Zhao
Pathogenic bacterial infection has been becoming as a global threat towards people's health, especially the massive usage of antibiotics due to the lack of antibacterial agents with less side-effects. Developing new nano-agents to fight pathogenic bacteria has provided enormous new possibilities in the treatment of bacterial infections, such as the graphene based 2D antibacterial nano-agents with different bacterial inhibition capabilities; however, mussel-inspired design of NIR-responsive and biocompatible Ag-graphene nano-agents possessed with efficient and versatile bacterial disinfection activities have rarely been reported...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235455/atmospheric-pressure-mass-spectrometric-imaging-of-live-hippocampal-tissue-slices-with-subcellular-spatial-resolution
#20
Jae Young Kim, Eun Seok Seo, Hyunmin Kim, Ji-Won Park, Dong-Kwon Lim, Dae Won Moon
We report a high spatial resolution mass spectrometry (MS) system that allows us to image live hippocampal tissue slices under open-air atmospheric pressure (AP) and ambient temperature conditions at the subcellular level. The method is based on an efficient desorption process by femtosecond (fs) laser assisted with nanoparticles and a subsequent ionization step by applying nonthermal plasma, termed AP nanoparticle and plasma assisted laser desorption ionization (AP-nanoPALDI) MS method. Combining the AP-nanoPALDI with microscopic sample scanning, MS imaging with spatial resolution of 2...
December 13, 2017: Nature Communications
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