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https://www.readbyqxmd.com/read/28647958/-prospective-cohort-study-on-the-outcomes-of-sacrospinous-ligament-fixation-using-conventional-instruments-in-treating-stage-%C3%A2-%C3%A2-pelvic-organ-prolapse
#1
C Ren, X C Song, L Zhu, F F Ai, H H Shi, Z J Sun, J Chen, J H Lang
Objective: To evaluate the medium and long term safety and efficacy of sacrospinous ligament fixation (SSLF) performed with conventional instruments in treating stage Ⅲ-Ⅳ pelvic organ prolapse (POP). Methods: A prospective cohort analysis was conducted in the Peking Union Medical College Hospital, between May 2007 and June 2015, enrolling 55 women with stage Ⅲ-Ⅳ POP who intended to receive SSLF. Primary end points were objective success rates using pelvic organ prolapse quantitation system (POP-Q) and subjective satisfaction rates with questionnaires after surgery according to vaginal examination and related questionnaires for all patients who received SSLF eventually...
June 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28645518/blood-gas-analyzer-accuracy-of-glucose-measurements
#2
Yafen Liang, Jonathan Wanderer, James H Nichols, David Klonoff, Mark J Rice
OBJECTIVE: To investigate the comparability of glucose levels measured with blood gas analyzers (BGAs) and by central laboratories (CLs). MATERIAL AND METHODS: Glucose measurements obtained between June 1, 2007, and March 1, 2016, at the Vanderbilt University Medical Center were reviewed. The agreement between CL and BGA results were assessed using Bland-Altman, consensus error grid (CEG), and surveillance error grid (SEG) analyses. We further analyzed the BGAs' performance against the US Food and Drug Administration (FDA) 2014 draft guidance and 2016 final guidance for blood glucose monitoring and the International Organization for Standardization (ISO) 15197:2013 standard...
June 7, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28643812/-conscience-clause-in-end-of-life-care
#3
Ludovica De Panfilis, Daniela Cattaneo, Luisanna Cola, Maddalena Gasparini, Corinna Porteri, Daniela Tarquini, Alessandro Tiezzi, Simone Veronese, Silvia Zullo, Eugenio Pucci
The article proposes a critical reflection on issues that appeal to the conscience clause as part of end of life care can produce and what can guarantee freedom of conscience, self-determination of those involved and respect for the dignity of the sick person. After a philosophical and normative analysis, the article is organized on the basis of two important documents for discussion: a position paper of Società Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI) signed by several scientific societies "Grandi insufficienze d'organo end stage: cure intensive o cure palliative?" and the Design of Law currently being debated "Norme in materia di consenso informato e di disposizioni anticipate di trattamento"...
May 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28643811/-from-mild-cognitive-impairment-to-dementia-what-is-the-role-of-public-health
#4
Nicola Vanacore, Alessandra Di Pucchio, Eleonora Lacorte, Ilaria Bacigalupo, Flavia Mayer, Giulia Grande, Matteo Cesari, Marco Canevelli
Mild cognitive impairment (MCI) is a nosological entity proposed by Petersen in 1999 with the objective of identifying an early stage of dementia. The new diagnostic criteria for dementia, both those promoted by the International Working Group (IWG) and those defined by the National Institute of Aging (NIA), subsequently introduced a new model that starts with a preclinical phase, then proceeds with a prodromal phase, and ends with a phase of dementia. The condition known as subjective cognitive disorder (SCD) is included between the preclinic and the prodromal phases...
May 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28641965/animal-models-of-psychoactive-drug-use-and-addiction-present-problems-and-future-needs-for-translational-approaches
#5
REVIEW
Christian P Müller
Drug addiction is a psychiatric disorder based on a dysfunction of the brain. It frequently develops from a controlled drug consumption and drug instrumentalization (DI). Thereby, DI is the use of a drug to improve specific non-drug related behaviors, beyond the drug's direct positive or negative reinforcing effects. Currently available pharmacotherapies for drug addiction show low effect size and rather limited long-term efficacy, which suggests that current theories on addiction are still insufficient in how they capture the phenomenon and how they allow predictions for highly efficient treatments...
June 19, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28641536/overview-of-forensic-toxicology-yesterday-today-and-in-the-future
#6
Heesun Chung, Sanggil Choe
BACKGROUND: The scope of forensic toxicology has been tremendously expanded over the past 50 years. From two general sections forensic toxicology can be further classified into 8-9 sections. METHODS: The most outstanding improvement in forensic toxicology is the changes brought by instrumental development. The field of forensic toxicology was revolutionized by the development of immunoassay and bench-top GC-MS in the 1980's and LC-MS-MS in 2000's. Detection of trace amounts of analytes has allowed the use of new specimens such as hair and oral fluids, along with blood and urine...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28640312/speciation-in-human-blood-of-metvan-a-vanadium-based-potential-anti-tumor-drug
#7
Daniele Sanna, Valeria Ugone, Giovanni Micera, Péter Buglyó, Linda Bíró, Eugenio Garribba
The first report on the anti-cancer activity of the compound Metvan, [V(IV)O(Me2phen)2(SO4)], where Me2phen is 4,7-dimethyl-1,10-phenanthroline, dates back to 2001. Although it was immediately identified as one of the most promising multitargeted anti-cancer V compounds, no development on the medical experimentation was carried out. One of the possible reasons is the lack of information on its speciation in aqueous solution and its thermodynamic stability, factors which influence the transport in the blood and the final form which reaches the target organs...
June 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28640246/gwas-signals-revisited-using-human-knockouts
#8
Sateesh Maddirevula, Fatema AlZahrani, Shams Anazi, Mariam Almureikhi, Tawfeg Ben-Omran, Ghada M H Abdel-Salam, Mais Hashem, Niema Ibrahim, Firdous M Abdulwahab, Neama Meriki, Fahad A Bashiri, Meow-Keong Thong, Premala Muthukumarasamy, Rifhan Azwani Mazlan, Ranad Shaheen, Fowzan S Alkuraya
PurposeGenome-wide association studies (GWAS) have been instrumental to our understanding of the genetic risk determinants of complex traits. A common challenge in GWAS is the interpretation of signals, which are usually attributed to the genes closest to the polymorphic markers that display the strongest statistical association. Naturally occurring complete loss of function (knockout) of these genes in humans can inform GWAS interpretation by unmasking their deficiency state in a clinical context.MethodsWe exploited the unique population structure of Saudi Arabia to identify novel knockout events in genes previously highlighted in GWAS using combined autozygome/exome analysis...
June 22, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28640089/functional-outcomes-of-gartland-iii-supracondylar-humerus-fractures-with-early-neurovascular-complications-in-children-a-retrospective-observational-study
#9
Sung Il Wang, Tae Young Kwon, Hong Pil Hwang, Jung Ryul Kim
This was a retrospective observational study. The aim of this study was to evaluate functional outcomes in children treated for Gartland III supracondylar humerus (SCH) fracture with neurovascular (NV) injuries using validated outcome measures. A secondary goal was to determine whether clinical parameters such as age at injury, sex, weight, fracture site, and/or direction of displacement could predict NV injury at the time of fracture or long-term functional outcomes in these patients.One hundred fifty-four patients of Gartland III SCH fractures between March 2004 and May 2013 were studied retrospectively...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28640030/flipped-classrooms-in-graduate-medical-education-a-national-survey-of-residency-program-directors
#10
Christopher M Wittich, Anoop Agrawal, Amy T Wang, Andrew J Halvorsen, Jayawant N Mandrekar, Saima Chaudhry, Denise M Dupras, Amy S Oxentenko, Thomas J Beckman
PURPOSE: To begin to quantify and understand the use of the flipped classroom (FC)-a progressive, effective, curricular model-in internal medicine (IM) education in relation to residency program and program director (PD) characteristics. METHOD: The authors conducted a survey that included the Flipped Classroom Perception Instrument (FCPI) in 2015 regarding programs' use and PDs' perceptions of the FC model. RESULTS: Among the 368 IM residency programs, PDs at 227 (61...
June 20, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28639877/mild-cognitive-impairment-and-changes-in-everyday-function-over-time-the-importance-of-evaluating-both-speed-and-accuracy
#11
Caroline L Lassen-Greene, Kayla Steward, Ozioma Okonkwo, Ellen Porter, Michael Crowe, David E Vance, H Randall Griffith, Karlene Ball, Daniel C Marson, Virginia G Wadley
OBJECTIVES: Research estimates that a significant percentage of individuals with mild cognitive impairment (MCI) experience functional difficulties. In addition to reduced accuracy on measures of everyday function, cross-sectional research has demonstrated that speed of performing instrumental activities of daily living (IADLs) is slowed in individuals with MCI. The present study investigated whether baseline and longitudinal changes in speed and accuracy of IADL performance differed between persons with MCI and cognitively normal peers...
July 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28639209/substance-use-and-misuse-among-children-and-youth-with-mental-illness-a%C3%A2-pilot-study
#12
V Herz, N Franzin, J Huemer, D Mairhofer, J Philipp, K Skala
OBJECTIVE: The aim of this study was to examine prevalence, patterns and predictors of substance use among a sample of adolescent psychiatric inpatients. METHODS: Participants included 25 minors aged 12-17 years admitted to an Austrian department of child and adolescent psychiatry. Lifetime use, initiation, frequency and quantity of substance use, sociodemographic, family and school-related data were collected by self-report measures. Substance use disorders were detected using CAGE (a screening instrument for problem drinking) and FTND (Fagerström Test For Nicotine Dependence)...
June 21, 2017: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/28639038/characteristics-predicting-laparoscopic-skill-in-medical-students-nine-years-experience-in-a-single-center
#13
Tsutomu Nomura, Takeshi Matsutani, Nobutoshi Hagiwara, Itsuo Fujita, Yoshiharu Nakamura, Yoshikazu Kanazawa, Hiroshi Makino, Yasuhiro Mamada, Terumichi Fujikura, Masao Miyashita, Eiji Uchida
INTRODUCTION: We introduced laparoscopic simulator training for medical students in 2007. This study was designed to identify factors that predict the laparoscopic skill of medical students, to identify intergenerational differences in abilities, and to estimate the variability of results in each training group. Our ultimate goal was to determine the optimal educational program for teaching laparoscopic surgery to medical students. METHODS: Between 2007 and 2015, a total of 270 fifth-year medical students were enrolled in this observational study...
June 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28638552/efficacy-of-three-methods-for-inserting-calcium-hydroxide-based-paste-in-root-canals
#14
Thales Galvão, Bernardo Camargo, Luciana Armada, Flávio Alves
BACKGROUND: To compare the quality of calcium hydroxide paste fillings performed by three different techniques. MATERIAL AND METHODS: Sixty extracted maxillary central incisors, with previous root canal treatment, were decoronated and the gutta-percha was completely removed from the root canals. Subsequently, the canals were filled with a calcium hydroxide-based paste composed of calcium hydroxide, bismuth carbonate, and glycerin. The study samples were divided into the following three groups on the basis of three insertion techniques (n = 20, each): conventional technique using a hand instrument (MAN), rotary Lentulo spiral (LEN) technique, and a combined technique combining conventional hand files with sonic activation through the EndoActivator device (EA)...
June 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28635536/women-s-experiences-with-vaginal-examinations-during-labor-in-the-netherlands
#15
Hannah W de Klerk, Elise Boere, Rik H van Lunsen, Jannet J H Bakker
INTRODUCTION: Vaginal digital examination (VE) is a routine medical procedure during labor to assess the start and progression of labor. This study explores women's experiences with VE's during labor in the Netherlands. METHODS: An exploratory anonymous online survey was distributed among Dutch women who underwent a trial of labor and gave birth to a living term child in the previous six months. Unadjusted odds ratios are calculated to establish associations between women's characteristics and reporting a negative experience with VE's...
February 22, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28635403/psychomotor-skills-assessment-by-motion-analysis-in-minimally-invasive-surgery-on-an-animal-organ
#16
Erlend Fagertun Hofstad, Cecilie Våpenstad, Lars Eirik Bø, Thomas Langø, Esther Kuhry, Ronald Mårvik
BACKGROUND: A high level of psychomotor skills is required to perform minimally invasive surgery (MIS) safely. To be able to measure these skills is important in the assessment of surgeons, as it enables constructive feedback during training. The aim of this study was to test the validity of an objective and automatic assessment method using motion analysis during a laparoscopic procedure on an animal organ. MATERIAL AND METHODS: Experienced surgeons in laparoscopy (experts) and medical students (novices) performed a cholecystectomy on a porcine liver box model...
February 8, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28635352/a-randomized-controlled-trial-comparing-two-types-of-retractors-at-caesarean-delivery
#17
Abbey J Hardy-Fairbanks, Todd Mackenzie, Martin McCarthy, Marlene B Goldman, Michele R Lauria
The aim of this study was to determine if the use of a self-retaining, symmetrical retractor (OB/Mobius(®)) during caesarean delivery is associated with differences in post-operative pain experience. Consenting women undergoing caesarean delivery were randomly assigned to OB/Mobius(®) versus conventional retraction instruments. Women were blinded to retractor type and filled out surgical pain surveys each post-operative day. Additional outcome variables were collected through a provider survey and chart review...
June 21, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28633172/burnout-and-depression-in-ms1-and-ms3-years-a-comparison-of-cohorts-at-one-medical-school
#18
Cinthia Elkins, Kyle P Plante, Lauren J Germain, Christopher P Morley
BACKGROUND: Losses of idealism, empathy, and professionalism over the course of medical education have been described previously in the literature. A 2012 national survey of medical students estimated 37%-44% with burnout, 58% screen positive for depression, and 9.4% with suicidal ideation in the past 12 months. Given changes in related traits, we sought to explore whether burnout and symptoms of depression change over time. The objectives of this study were to assess the differences in medical student burnout and symptoms of depression between first year (MS1) and third-year (MS3) medical students at one medical college...
June 2017: Family Medicine
https://www.readbyqxmd.com/read/28633095/development-and-validation-of-the-polish-version-of-the-urogenital-distress-inventory-short-form-and-the-incontinence-impact-questionnaire-short-form
#19
Katarzyna A Skorupska, Pawel Miotla, Agnieszka Kubik-Komar, Pawel Skorupski, Tomasz Rechberger
OBJECTIVE: The Incontinence Impact Questionnaire (IIQ) measures the impact of urinary incontinence on activities, roles, and emotional states of women, whereas the Urogenital Distress Inventory (UDI) measures how troubling the symptoms are. The aim of this study was to develop and assess the effectiveness of a Polish version of the IIQ and UDI. STUDY DESIGN: The translation into Polish followed standardized procedures. 206 women aged between 31 and 83 years were included into the study...
June 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28632916/diastasis-of-the-pubic-symphysis-following-vaginal-delivery
#20
Bhumireddy Sujana, Anish Keepanasseril, Dilip K Maurya
Diastasis of the pubic symphysis following vaginal delivery has been reported to occur during 1 in 300-30 000 deliveries [1, 2]. The present study describes two patients who presented at the Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India, between July 2014 and December 2015 immediately postpartum after instrumental vaginal delivery. The patients provided written informed consent for the publication of the present study. This article is protected by copyright. All rights reserved...
June 20, 2017: International Journal of Gynaecology and Obstetrics
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