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https://www.readbyqxmd.com/read/28742723/supraglottic-atomization-of-surfactant-in-spontaneously-breathing-lambs-receiving-continuous-positive-airway-pressure
#1
Ilaria Milesi, David G Tingay, Anna Lavizzari, Federico Bianco, Emanuela Zannin, Paolo Tagliabue, Fabio Mosca, Maria Luisa Ventura, Anushi Rajapaksa, Elizabeth J Perkins, Don Black, Marco Di Castri, Magdy Sourial, Gerhard Pohlmann, Raffaele L Dellaca'
OBJECTIVES: To determine the short-term tolerance, efficacy, and lung deposition of supraglottic atomized surfactant in spontaneously breathing lambs receiving continuous positive airway pressure. DESIGN: Prospective, randomized animal study. SETTING: Animal research laboratory. SUBJECTS: Twenty-two preterm lambs on continuous positive airway pressure (132 ± 1 d gestational age). INTERVENTIONS: Animals receiving continuous positive airway pressure via binasal prongs at 8 cm H2O were randomized to receive atomized surfactant at approximately 60-minute of life (atom; n = 15) or not (control; n = 7)...
July 22, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28741448/the-burden-and-visit-prevalence-of-pediatric-chronic-rhinosinusitis
#2
Sapideh Gilani, Jennifer J Shin
Objectives Pediatric chronic rhinosinusitis has a substantial impact, but its epidemiology has yet to be elucidated. Our objectives were (1) to determine the associated national visit burden and (2) to assess its frequency relative to other frequent childhood otolaryngological illnesses. Study Design Analysis of national survey databases. Setting Ambulatory care settings in the United States, 2005 to 2012. Subjects and Methods Cases with a diagnosis of chronic rhinosinusitis were assessed in total and as a proportion of all visits reported in National Ambulatory Medical Care Surveys...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28741375/comparison-of-slow-and-forced-vital-capacities-on-ability-to-predict-survival-in-als
#3
Susana Pinto, Mamede de Carvalho
INTRODUCTION: Slow (SVC) and forced (FVC) vital capacities are the most used pulmonary function tests in amyotrophic lateral sclerosis (ALS). It is unknown if they equally predict survival in ALS. The aim of the present study was to compare both measures in predicting survival in this disease. METHODS: Consecutive definite/probable ALS patients (2000-2014) in whom respiratory tests were performed at baseline and four months later were included. All patients were evaluated with the revised ALS functional rating scale (ALSFRS-R), respiratory (RofALSFRS-R), bulbar (ALSFRSb), upper and lower limb subscores, SVC, FVC, maximal inspiratory (MIP) and expiratory (MEP) pressures...
July 25, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28740835/severe-pulmonary-hypertension-due-to-combined-pulmonary-fibrosis-and-emphysema-another-cause-of-death-among-smokers
#4
REVIEW
André Carramenha de Góes Hirano, Eduardo Pelegrineti Targueta, Fernando Peixoto Ferraz de Campos, João Augusto Dos Santos Martines, Dafne Andrade, Silvana Maria Lovisolo, Aloisio Felipe-Silva
In 2005, the combined pulmonary fibrosis and emphysema (CPFE) was first defined as a distinct entity, which comprised centrilobular or paraseptal emphysema in the upper pulmonary lobes, and fibrosis in the lower lobes accompanied by reduced diffused capacity of the lungs for carbon monoxide (DLCO). Recently, the fibrosis associated with the connective tissue disease was also included in the diagnosis of CPFE, although the exposure to tobacco, coal, welding, agrochemical compounds, and tire manufacturing are the most frequent causative agents...
April 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/28740426/efficacy-of-flurbiprofen-8-75-mg-delivered-as-a-spray-or-lozenge-in-patients-with-sore-throat-due-to-upper-respiratory-tract-infection-a-randomized-non-inferiority-trial-in-the-russian-federation
#5
Eugenia Radkova, Natalia Burova, Valeria Bychkova, Robert DeVito
OBJECTIVE: To assess the efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection (URTI). MATERIALS AND METHODS: This multicenter, double-blind, double-dummy, non-inferiority study randomized 440 adults with recent-onset, moderate-to-severe sore throat due to URTI to a single dose of either flurbiprofen 8.75 mg spray (n=218) or flurbiprofen 8.75 mg lozenge (n=222). The presence or absence of beta-hemolytic streptococci (A or C) was confirmed by culture tests (throat swab)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28739424/respiratory-viruses-in-transplant-recipients-more-than-just-a-cold-clinical-syndromes-and-infection-prevention-principles
#6
REVIEW
Salma Abbas, Jillian E Raybould, Sangeeta Sastry, Oveimar de la Cruz
OBJECTIVES: The aim of this review is to provide updated information on the clinical spectrum, treatment options, and infection prevention strategies for respiratory viral infections (RVI) in both solid organ (SOT) and hematopoietic stem cell transplant (HSCT) patients. METHODS: We searched the MEDLINE and Pubmed databases for literature regarding the aforementioned aspects of RVIs, with focus on respiratory syncytial virus, adenovirus, influenza, parainfluenza, human metapneumovirus and rhinovirus...
July 21, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28739272/an-on-line-analytical-approach-for-detecting-haptens-in-shuang-huang-lian-powder-injection
#7
Hong Wang, Xiaotian Zhang, Daidong Wang, Hongyang Sun, Yuexiang Lan, Haixiu Jiang, Shizhong Chen, Zongtao Lin
Shuang-huang-lian powder injection (SHLPI) is a traditional Chinese medicine injection (TCMI) frequently used in the clinical treatment of faucitis, bronchitis, and other viral and bacterial infections of upper respiratory tract. However, its allergenic reactions, being the main adverse effects (AEs) of SHLPI, have been a serious problem of its clinical safety. This problem has not been solved due to short of methods for detecting haptens in complex TCMIs. In this study, an on-line high-performance liquid chromatography-diode-array detector-mass spectrometry combined with bovine serum albumin-fluorescence detector (HPLC-DAD-MS-BSA-FLD) system was established for the first time, validated and applied for identification of haptens in SHLPI...
July 13, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28739160/using-heat-maps-to-assess-the-multidimensional-association-of-comorbidities-with-survival-in-older-cancer-patients-treated-with-chemotherapy
#8
Jae Jin Lee, Jongphil Kim, Marina Sehovic, Lu Chen, Martine Extermann
OBJECTIVE: To date, most comorbidity studies have analyzed either a subgroup of frequent diseases, or used summary instruments such as the Charlson score or the Cumulative Illness Rating Scale-Geriatric (CIRS-G). Yet, comorbidity is a multidimensional construct and impacts function, treatment tolerance, and survival. We assessed how heat maps can unveil specific patterns of comorbidities associated with overall survival (OS) in older cancer patients treated with chemotherapy. MATERIAL AND METHODS: We reviewed four trials that prospectively evaluated comorbidities using CIRS-G...
July 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28738382/advanced-concepts-in-the-pathophysiology-of-obstructive-sleep-apnea
#9
David P White
The primary pathological event in the disorder obstructive sleep apnea (OSA) is the partial or complete closure of the pharyngeal airway during sleep in an individual with a widely patent airway during wakefulness. This yields an apnea or hypopnea with resulting hypoxia and hypercapnia, and most often requires an arousal to terminate the event. These events occur in a repetitive manner during sleep, yielding intermittent hypoxia and sleep fragmentation with their associated adverse effects on the health and quality of life of the afflicted individual...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28735916/morbidity-and-mortality-of-middle-aged-and-elderly-narcoleptics
#10
Poul Jennum, Eva Wiberg Thorstensen, Line Pickering, Rikke Ibsen, Jakob Kjellberg
OBJECTIVES: The objective of the study was to evaluate the morbidities and mortality in a national group of middle-aged and elderly narcolepsy patients before and after the first diagnosis of the condition. METHODS: From the Danish National Patient Registry (NPR), 1174 patients (45.1% males) aged 20-59 years and 339 patients (44.8% males) aged 60+ who received a diagnosis of narcolepsy between 1998 and 2014 were compared, respectively, with 4716 and 1353 control citizens matched for age, gender and geography, who were randomly chosen from the Danish Civil Registration System Statistics...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28734862/respiratory-infections-and-antibiotic-usage-in-common-variable-immunodeficiency
#11
Johannes M Sperlich, Bodo Grimbacher, Sarita Workman, Tanzina Haque, Suranjith L Seneviratne, Siobhan O Burns, Veronika Reiser, Werner Vach, John R Hurst, David M Lowe
BACKGROUND: Patients with common variable immunodeficiency (CVID) suffer frequent respiratory tract infections despite immunoglobulin replacement and are prescribed significant quantities of antibiotics. The clinical and microbiological nature of these exacerbations, the symptomatic triggers to take antibiotics, and the response to treatment have not been previously investigated. OBJECTIVES: To describe the nature, frequency, treatment, and clinical course of respiratory tract exacerbations in patients with CVID and to describe pathogens isolated during respiratory tract exacerbations...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28734844/tlr3-blockade-in-rhinovirus-induced-experimental-asthma-exacerbations-a-randomized-controlled-study
#12
Philip E Silkoff, Susan Flavin, Robert Gordon, Mathew J Loza, Peter J Sterk, Rene Lutter, Zuzana Diamant, Ronald B Turner, Brian J Lipworth, David Proud, Dave Singh, Andreas Eich, Vibeke Backer, James E Gern, Christian Herzmann, Scott A Halperin, Tjeert T Mensinga, Alfred M Del Vecchio, Patrick Branigan, Lani San Mateo, Frédéric Baribaud, Elliot S Barnathan, Sebastian L Johnston
BACKGROUND: Human rhinoviruses (HRV) commonly precipitate asthma exacerbations. TLR3, an innate pattern-recognition receptor, is triggered by HRV driving inflammation that may worsen asthma. OBJECTIVE: To evaluate an inhibitory monoclonal antibody to TLR3, CNTO3157, on experimental HRV-16 inoculation in healthy and asthmatic subjects. METHODS: In this double-blind multicenter randomized parallel-group study in North America and Europe, healthy and mild-moderate stable asthmatic subjects received single or multiple doses of CNTO 3157 or placebo, respectively, and were then inoculated with HRV-16 within 72 hours...
July 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28733724/motion-monitoring-during-a%C3%A2-course-of-lung-radiotherapy-with-anchored-electromagnetic-transponders-quantification-of-inter-and-intrafraction-motion-and-variability-of-relative-transponder-positions
#13
Daniela Schmitt, Simeon Nill, Falk Roeder, Daniela Gompelmann, Felix Herth, Uwe Oelfke
PURPOSE: Anchored electromagnetic transponders for tumor motion monitoring during lung radiotherapy were clinically evaluated. First, intrafractional motion patterns were analyzed as well as their interfractional variations. Second, intra- and interfractional changes of the geometric transponder positions were investigated. MATERIALS AND METHODS: Intrafractional motion data from 7 patients with an upper or middle lobe tumor and three implanted transponders each was used to calculate breathing amplitudes, overall motion amount and motion midlines in three mutual perpendicular directions and three-dimensionally (3D) for 162 fractions...
July 21, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28732841/cobalt-related-interstitial-lung-disease
#14
REVIEW
Traci N Adams, Yasmeen M Butt, Kiran Batra, Craig S Glazer
Cobalt exposure in the hard metal and bonded diamond tool industry is a well-established cause of ILD. The primary theories regarding the underlying mechanism of cobalt related ILD include an immunologic mechanism and an oxidant injury mechanism. Cobalt related ILD may present in subacute and chronic forms and often has associated upper respiratory symptoms. The evaluation begins with a thorough occupational history and includes PFTs, HRCT, and bronchoalveolar lavage. HRCT findings are nonspecific and may resemble NSIP, UIP, sarcoidosis, or HP...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28732785/previous-antibiotic-related-adverse-drug-reactions-do-not-reduce-expectations-for-antibiotic-treatment-of-upper-respiratory-tract-infections
#15
Stephen R Ritchie, Kalpa J Jayanatha, Eamon J Duffy, James Chancellor, Zarah Allport, Mark G Thomas
BACKGROUND: Patients' expectations may influence prescribers' decisions about antibiotic prescribing for upper respiratory tract infection (URTI). We examined whether a history of an antibiotic related adverse drug reaction (aADR) influenced a person's perception about the safety of antibiotics or their expectation of receiving an antibiotic prescription for an URTI. METHODS: We developed a questionnaire and surveyed 103 hospital inpatients, 38 of whom (37%) reported past experience of aADR...
July 18, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28732152/secukinumab-in-the-treatment-of-psoriasis-and-psoriatic-arthritis-a-review-of-the-literature
#16
M Abrouk, J Gandy, M Nakamura, K Lee, M Brodsky, R Singh, H Zhu, B Farahnik, T Bhutani, J Koo
While there are several commercially available treatment options for psoriasis and psoriatic arthritis, there remains a large number of individuals who are refractory to current modalities. In the recent past, there has been increasing evidence that interleukin (IL)-17 plays a vital role in the pathophysiology of psoriasis. Preclinical, phase II, and phase III studies of secukinumab (Cosentyx®) targeting IL-17 and its receptor have thus far proved to be promising. We reviewed the results of phase II and phase III clinical trials for secukinumab in the treatment of psoriasis and psoriatic arthritis...
July 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/28731410/infectious-and-noninfectious-pulmonary-complications-in-patients-with-primary-immunodeficiency-disorders
#17
REVIEW
R Yazdani, H Abolhassani, M Asgardoon, M Shaghaghi, M Modaresi, G Azizi, A Aghamohammadi
Primary immunodeficiency disorders (PIDs) are caused by 1 or more defects of the immune system. Patients are more likely to experience recurrent and/or severe infections and tend to develop a wide range of complications. Respiratory diseases are the main and initial manifestation in most cases and the most common complication. Pulmonary complications cause significant morbidity and mortality in patients with PIDs. Early diagnosis and appropriate treatment can prevent or at least slow the development of respiratory complications...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28731388/electronic-visits-for-minor-acute-illnesses-analysis-of-patient-demographics-prescription-rates-and-follow-up-care-within-an-asynchronous-text-based-online-visit
#18
Kristine S Penza, Martha A Murray, Jennifer L Pecina, Jane F Myers, Joseph W Furst
INTRODUCTION: Patients can obtain medical advice and treatment from a healthcare provider asynchronously through an electronic visit (eVisit) within a secure online portal. METHODS: We conducted a retrospective record review of Mayo Clinic Rochester primary care empaneled patients who had an eVisit for a minor acute illness and were reviewed for 30-day outcomes of follow-up. RESULTS: Of the 1,009 eVisits analyzed, a total of 340 (34%) had follow-up within 30 days, with a follow-up rate of 154 (20%) when those who were advised to follow-up were excluded...
July 20, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28727669/differential-pulmonary-rehabilitation-outcomes-in-patients-with-and-without-copd-role-of-gender
#19
Lam-Phuong Nguyen, Emily Beck, Katherine Cayetano, Chin-Shang Li, Kimberly Hardin
PURPOSE: Individuals with all forms of pulmonary disease are referred for pulmonary rehabilitation. This study examines pulmonary rehabilitation outcomes between individuals with chronic obstructive lung disease (COPD) and non-COPD disease and the impact of gender. METHODS: This is a retrospective study at a tertiary center. The primary endpoint was the difference in 6-min walk test distance. Secondary measurements included treadmill and NuStep minutes; biceps curls and front arm raises load; quality of life measured by the St George's Respiratory Questionnaire; and University of California San Diego-Shortness of Breath Questionnaire (UCSD-SOBQ) scores...
July 19, 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28722615/assessing-the-short-term-global-health-experience-a-cross-sectional-study-of-demographics-socioeconomic-factors-and-disease-prevalence
#20
Olivia Geen, Allison Pumputis, Cristina Kochi, Andrew Costa, Karl Stobbe
Interest in short-term global health experiences to underserviced populations has grown rapidly in the last few decades. However, there remains very little research on what participants can expect to encounter. At the same time, it has been suggested that in order for physicians and workers to provide safe and effective care, volunteers should have a basic understanding of local culture, health systems, epidemiology, and socioeconomic needs of the community before arriving. Our objective was to add to the limited literature on what short-term global health trips can expect to encounter through a cross-sectional study of patient demographics, socioeconomic markers, and the prevalence of diseases encountered on a short-term medical service trip to Lima, Peru...
June 12, 2017: American Journal of Tropical Medicine and Hygiene
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