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https://www.readbyqxmd.com/read/28282247/effect-of-tenofovir-disoproxil-fumarate-on-incidence-of-chronic-kidney-disease-and-rate-of-estimated-glomerular-filtration-rate-decrement-in-hiv-1-infected-treatment-na%C3%A3-ve-asian-patients-results-from-12-year-observational-cohort
#1
Soichiro Suzuki, Takeshi Nishijima, Yohei Kawasaki, Takuma Kurosawa, Yoshikazu Mutoh, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
Little evidence is available for the incidence of chronic kidney disease (CKD) and rate of estimated glomerular filtration rate (eGFR) decrement among Asians with low body weight who are susceptible to tenofovir disoproxil fumarate (TDF) nephrotoxicity. In this 12-year observational cohort in Tokyo, we examined 1383 treatment-naïve HIV-1-infected Asians [720 started TDF-containing (TDF group) and 663 started non-TDF-containing (control) combination antiretroviral therapy (cART)]. The CKD incidence was calculated, and the effect of TDF use on CKD development was estimated using logistic regression...
March 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28122944/constipation-and-incident-ckd
#2
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Kunihiro Matsushita, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
Constipation is one of the most prevalent conditions in primary care settings and increases the risk of cardiovascular disease, potentially through processes mediated by altered gut microbiota. However, little is known about the association of constipation with CKD. In a nationwide cohort of 3,504,732 United States veterans with an eGFR ≥60 ml/min per 1.73 m(2), we examined the association of constipation status and severity (absent, mild, or moderate/severe), defined using diagnostic codes and laxative use, with incident CKD, incident ESRD, and change in eGFR in Cox models (for time-to-event analyses) and multinomial logistic regression models (for change in eGFR)...
November 10, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28087576/circulating-modified-metabolites-and-a-risk-of-esrd-in-patients-with-type-1-diabetes-and-chronic-kidney-disease
#3
Monika A Niewczas, Anna V Mathew, Stephanie Croall, Jaeman Byun, Melissa Major, Venkatta S Sabisetti, Adam Smiles, Joseph V Bonventre, Subramaniam Pennathur, Andrzej S Krolewski
OBJECTIVE: Patients with type 1 diabetes (T1D) with impaired renal function are at increased risk for end-stage renal disease (ESRD). Although the rate of progression varies, determinants and mechanisms of this variation are unknown. RESEARCH DESIGN AND METHODS: We examined serum metabolomic profiles associated with variation in renal function decline in participants with T1D (the Joslin Kidney Study prospective cohort). One hundred fifty-eight patients with proteinuria and chronic kidney disease stage 3 were followed for a median of 11 years to determine estimated glomerular filtration rate slopes from serial measurements of serum creatinine and to ascertain time to onset of ESRD...
March 2017: Diabetes Care
https://www.readbyqxmd.com/read/27806460/importance-of-comprehensive-cardiovascular-screening-in-patients-scheduled-for-kidney-donation
#4
Hala Soomro, Aisha Rasool Saand, Zaid Soomro, Mustafa Naseer, Zohaib Farrukh, Arbab Burhan Uddin Kasi, Sarah Hamid, Anika Bilal, Madiha Ahmed, Ali Raza, Tahreem Ahmad, Saif Raza, Ayyaz Alam Sultan, Rohail Jameel, Maaz Hasan Khan, Maha Begg
INTRODUCTION: End stage renal disease is on the rise in many parts of the world. Kidney transplant is a common procedure and definitive treatment for end stage renal disease. Along with its various advantages, it presents with an array of complications, associated with the procedure. Hence, an effective screening program to identify eligible donors is of crucial importance. The main aim of this study was to identify the frequency of possible undetected cardiovascular abnormalities in scheduled donors and its association with gender...
June 30, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27729571/genome-wide-association-of-ckd-progression-the-chronic-renal-insufficiency-cohort-study
#5
Afshin Parsa, Peter A Kanetsky, Rui Xiao, Jayanta Gupta, Nandita Mitra, Sophie Limou, Dawei Xie, Huichun Xu, Amanda Hyre Anderson, Akinlolu Ojo, John W Kusek, Claudia M Lora, L Lee Hamm, Jiang He, Niina Sandholm, Janina Jeff, Dominic E Raj, Carsten A Böger, Erwin Bottinger, Shabnam Salimi, Rulan S Parekh, Sharon G Adler, Carl D Langefeld, Donald W Bowden, Per-Henrik Groop, Carol Forsblom, Barry I Freedman, Michael Lipkowitz, Caroline S Fox, Cheryl A Winkler, Harold I Feldman
The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome-wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We stratified all analyses by race and subsequently, diabetes status. Single-nucleotide polymorphisms (SNPs) that surpassed a significance threshold of P<1×10(-6) for association with eGFR slope were selected as candidates for follow-up and secondarily tested for association with proteinuria and time to ESRD...
March 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27647852/patterns-of-estimated-glomerular-filtration-rate-decline-leading-to-end-stage-renal-disease-in-type-1-diabetes
#6
Jan Skupien, James H Warram, Adam M Smiles, Robert C Stanton, Andrzej S Krolewski
OBJECTIVE: The patterns of estimated glomerular filtration rate (eGFR) decline to end-stage renal disease (ESRD) in patients with type 1 diabetes has not been conclusively described. Decline could be linearly progressive to ESRD but with a variable rate. Conversely, decline may be linear but interrupted by periods of plateaus or improvements. RESEARCH DESIGN AND METHODS: This observational study included 364 patients with type 1 diabetes attending the Joslin Clinic who developed ESRD between 1991 and 2013...
December 2016: Diabetes Care
https://www.readbyqxmd.com/read/27593903/comparing-the-gfr-estimation-equations-using-both-creatinine-and-cystatin-c-to-predict-the-long-term-renal-outcome-in-type-2-diabetic-nephropathy-patients
#7
Yu Pan, Song Jiang, Dandan Qiu, Jingsong Shi, Minlin Zhou, Yu An, Yongchun Ge, Honglang Xie, Zhihong Liu
AIMS: This study aimed to determine whether eGFRcre-cys and its slope could improve the prediction of the long-term renal outcome in patients with type 2 diabetic nephropathy (DN). METHODS: The cross-sectional and longitudinal analyses included 501 type 2DN patients from 2003 to 2009. GFR was estimated using either eGFRcre-cys or the serum creatinine-based equation (eGFRcre) or the cystatin C-based equation (eGFRcys), and was classified into 3 categories (≥90, 60-90, ≤60ml/min per 1...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27557557/risk-factors-for-progression-in-children-and-young-adults-with-iga-nephropathy-an-analysis-of-261-cases-from-the-valiga-european-cohort
#8
Rosanna Coppo, Danilo Lofaro, Roberta R Camilla, Shubha Bellur, Daniel Cattran, H Terence Cook, Ian S D Roberts, Licia Peruzzi, Alessandro Amore, Francesco Emma, Laura Fuiano, Ulla Berg, Rezan Topaloglu, Yelda Bilginer, Loreto Gesualdo, Rosaria Polci, Malgorzata Mizerska-Wasiak, Yasar Caliskan, Sigrid Lundberg, Giovanni Cancarini, Colin Geddes, Jack Wetzels, Andrzej Wiecek, Magdalena Durlik, Stefano Cusinato, Cristiana Rollino, Milena Maggio, Manuel Praga, Hilde K Smerud, Vladimir Tesar, Dita Maixnerova, Jonathan Barratt, Teresa Papalia, Renzo Bonofiglio, Gianna Mazzucco, Costantinos Giannakakis, Magnus Soderberg, Diclehan Orhan, Anna Maria Di Palma, Jadwiga Maldyk, Yasemin Ozluk, Birgitta Sudelin, Regina Tardanico, David Kipgen, Eric Steenbergen, Henryk Karkoszka, Agnieszka Perkowska-Ptasinska, Franco Ferrario, Eduardo Gutierrez, Eva Honsova
BACKGROUND: There is a need for early identification of children with immunoglobulin A nephropathy (IgAN) at risk of progression of kidney disease. METHODS: Data on 261 young patients [age <23 years; mean follow-up of 4.9 (range 2.5-8.1) years] enrolled in VALIGA, a study designed to validate the Oxford Classification of IgAN, were assessed. Renal biopsies were scored for the presence of mesangial hypercellularity (M1), endocapillary hypercellularity (E1), segmental glomerulosclerosis (S1), tubular atrophy/interstitial fibrosis (T1-2) (MEST score) and crescents (C1)...
January 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27550651/regional-trends-in-avoidable-hospitalisations-due-to-complications-among-population-with-diabetes-in-finland-in-1996-2011-a-register-based-cohort-study
#9
Kristiina Manderbacka, Martti Arffman, Sonja Lumme, Markku Lehikoinen, Klas Winell, Ilmo Keskimäki
OBJECTIVES: Diabetes requires continuous medical care including prevention of acute complications and risk reduction for long-term complications. Diabetic complications impose a substantial burden on public health and care delivery. We examined trends in regional differences in hospitalisations due to diabetes-related complications among the total diabetes population in Finland. RESEARCH DESIGN: A longitudinal register-based cohort study 1996-2011 among a total population with diabetes in Finland...
2016: BMJ Open
https://www.readbyqxmd.com/read/27295898/-autosomal-dominant-polycystic-kidney-disease-how-and-why-should-we-identify-the-patients-rapidly-progressing-to-end-stage-renal-disease
#10
A Bodson, P Meunier, J-M Krzesinski, F Jouret
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterised by the progressive development of multiple and bilateral cysts in kidneys and other organs. Most patients with ADPKD will develop, sooner or later, end-stage renal disease (ESRD). The morbidity and mortality associated with ESRD prompt physicians to identify early ADPKD patients considered as "rapid progressors", who have the greatest risk to rapidly develop ESRD. The rate of progression can be assessed by clinical--especially with the "predicting renal outcome in polycystic kidney disease score" (PROPKD-Score)-, biological (a decline of the glomerular filtration rate (GFR) of 4...
April 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/27242372/association-between-vascular-access-creation-and-deceleration-of-estimated-glomerular-filtration-rate-decline-in-late-stage-chronic-kidney-disease-patients-transitioning-to-end-stage-renal-disease
#11
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Vanessa A Ravel, Melissa Soohoo, Connie M Rhee, Elani Streja, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND: Prior studies have suggested that arteriovenous fistula (AVF) or graft (AVG) creation may be associated with slowing of estimated glomerular filtration rate (eGFR) decline. It is unclear if this is attributable to the physiological benefits of a mature access on systemic circulation versus confounding factors. METHODS: We examined a nationwide cohort of 3026 US veterans with advanced chronic kidney disease (CKD) transitioning to dialysis between 2007 and 2011 who had a pre-dialysis AVF/AVG and had at least three outpatient eGFR measurements both before and after AVF/AVG creation...
May 30, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27163501/pharmacokinetics-of-the-long-acting-basal-insulin-ly2605541-in-subjects-with-varying-degrees-of-renal-function
#12
Helle Linnebjerg, Siak Leng Choi, Eric Chen Quin Lam, Kenneth F Mace, Teri S Hodgson, Vikram P Sinha
The pharmacokinetics of LY2605541 (basal insulin peglispro), a novel long-acting basal insulin analogue, was evaluated in 5 groups of subjects with varying degrees of renal function based on creatinine clearance: normal renal function (>80 mL/min), mild renal impairment (51-80 mL/min), moderate renal impairment (30-50 mL/min), severe renal impairment (<30 mL/min), or end-stage renal disease (ESRD) requiring hemodialysis. Serial blood samples for pharmacokinetic analyses were collected up to 12 days following a single 0...
May 2016: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/27151925/ckd-progression-and-mortality-among-hispanics-and-non-hispanics
#13
Michael J Fischer, Jesse Y Hsu, Claudia M Lora, Ana C Ricardo, Amanda H Anderson, Lydia Bazzano, Magdalena M Cuevas, Chi-Yuan Hsu, John W Kusek, Amada Renteria, Akinlolu O Ojo, Dominic S Raj, Sylvia E Rosas, Qiang Pan, Kristine Yaffe, Alan S Go, James P Lash
Although recommended approaches to CKD management are achieved less often in Hispanics than in non-Hispanics, whether long-term outcomes differ between these groups is unclear. In a prospective longitudinal analysis of participants enrolled into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies, we used Cox proportional hazards models to determine the association between race/ethnicity, CKD progression (50% eGFR loss or incident ESRD), incident ESRD, and all-cause mortality, and linear mixed-effects models to assess differences in eGFR slope...
November 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27032886/early-change-in-urine-protein-as-a-surrogate-end-point-in-studies-of-iga-nephropathy-an-individual-patient-meta-analysis
#14
Lesley A Inker, Hasi Mondal, Tom Greene, Taylor Masaschi, Francesco Locatelli, Francesco P Schena, Ritsuko Katafuchi, Gerald B Appel, Bart D Maes, Philip K Li, Manuel Praga, Lucia Del Vecchio, Simeone Andrulli, Carlo Manno, Eduardo Gutierrez, Alex Mercer, Kevin J Carroll, Christopher H Schmid, Andrew S Levey
BACKGROUND: The role of change in proteinuria as a surrogate end point for randomized trials in immunoglobulin A nephropathy (IgAN) has previously not been thoroughly evaluated. STUDY DESIGN: Individual patient-level meta-analysis. SETTING & POPULATION: Individual-patient data for 830 patients from 11 randomized trials evaluating 4 intervention types (renin-angiotensin system [RAS] blockade, fish oil, immunosuppression, and steroids) examining associations between changes in urine protein and clinical end points at the individual and trial levels...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27031662/the-effects-of-cytotoxic-therapy-in-progressive-iga-nephropathy
#15
COMPARATIVE STUDY
Jung-ho Shin, Jung Eun Lee, Ji Hyeon Park, Sharon Lim, Hye Ryoun Jang, Ghee Young Kwon, Wooseong Huh, Sin-Ho Jung, Yoon-Goo Kim, Ha Young Oh, Dae Joong Kim
BACKGROUND: IgA nephropathy (IgAN) is not always benign, and some patients at high risk of end-stage renal disease (ESRD) experience a rapid decline in renal function. This study retrospectively examined the beneficial effects of cytotoxic therapy. METHODS: We identified 102 patients with progressive IgAN despite optimal conservative management. Of these, 31 who received cytotoxic therapy and 55 who were managed conservatively were included. RESULTS: Median eGFR and urinary protein-to-creatinine ratio (uPCR) at baseline did not differ between the groups (p = 0...
2016: Annals of Medicine
https://www.readbyqxmd.com/read/26993562/childhood-albuminuria-and-chronic-kidney-disease-is-associated-with-mortality-and-end-stage-renal-disease
#16
Ching-Yuang Lin, Shiuh-Ming Huang
BACKGROUND: We do not yet fully grasp the significance of childhood albuminuria. Based on mass urinary screening (MUS) using albumin-specific dipsticks in school children, we studied the independent association of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in children with chronic kidney disease (CKD). METHODS: A prospective cohort of 5351 children with albuminuria detected by school MSU during the period 1992-1996, followed up to 2009...
August 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/26848002/association-of-slopes-of-estimated-glomerular-filtration-rate-with-post-end-stage-renal-disease-mortality-in-patients-with-advanced-chronic-kidney-disease-transitioning-to-dialysis
#17
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Jennie Jing, Vanessa A Ravel, Melissa Soohoo, Connie M Rhee, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
OBJECTIVE: To investigate the association of estimated glomerular filtration rate (eGFR) slopes before dialysis initiation with cause-specific mortality after dialysis initiation. PATIENTS AND METHODS: In this retrospective cohort study of 18,874 US veterans who had transitioned to dialysis from October 1, 2007, through September 30, 2011, we examined the association of pre-end-stage renal disease (ESRD) eGFR slopes with all-cause, cardiovascular, and infection-related mortality during the post-ESRD period over a median follow-up of 2...
February 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26724837/kidney-disease-in-adenine-phosphoribosyltransferase-deficiency
#18
Hrafnhildur Linnet Runolfsdottir, Runolfur Palsson, Inger M Agustsdottir, Olafur S Indridason, Vidar O Edvardsson
BACKGROUND: Adenine phosphoribosyltransferase (APRT) deficiency is a purine metabolism disorder causing kidney stones and chronic kidney disease (CKD). The course of nephrolithiasis and CKD has not been well characterized. The objective of this study was to examine long-term kidney outcomes in patients with APRT deficiency. STUDY DESIGN: An observational cohort study. SETTING & PARTICIPANTS: All patients enrolled in the APRT Deficiency Registry of the Rare Kidney Stone Consortium...
March 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26663437/recovery-of-renal-function-after-radical-nephrectomy-and-risk-factors-for-postoperative-severe-renal-impairment-a-japanese-multicenter-longitudinal-study
#19
MULTICENTER STUDY
Naoko Kawamura, Minato Yokoyama, Yasuhisa Fujii, Junichiro Ishioka, Noboru Numao, Yoh Matsuoka, Kazutaka Saito, Chizuru Arisawa, Tetsuo Okuno, Akira Noro, Shinji Morimoto, Kazunori Kihara
OBJECTIVES: To investigate longitudinal changes in renal function after radical nephrectomy, and to explore risk factors of postoperative severe renal impairment in a Japanese multicenter cohort. METHODS: The present retrospective study included 701 patients who had no metastasis, end-stage kidney disease or bilateral kidney cancer, who underwent radical nephrectomy and who were followed up for at least 1 year. The longitudinal change in postoperative renal function during a 10-year follow-up period was evaluated according to the presence or absence of potential risk factors including greater age, chronic kidney disease, hypertension, diabetes mellitus and cardiovascular disease...
March 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/26519376/role-of-renin-angiotensin-system-inhibitors-in-retardation-of-progression-of-end-stage-renal-failure-a-retrospective-study
#20
Tomoyuki Murakami, Tamio Iwamoto, Gen Yasuda, Michiko Taniguchi, Akira Fujiwara, Nobuhito Hirawa, Satoshi Umemura
BACKGROUND: Few studies have examined how renin-angiotensin system inhibitors (RASI) delay dialysis initiation in patients with advanced chronic kidney disease (CKD). We conducted a retrospective survey to examine this subject. METHODS: We reviewed the records of patients with advanced CKD for the 60-month period before dialysis initiation between 1990 and 2015. Patients were classified based on the decade of dialysis initiation into the 1990s, 2000s, and 2010s groups...
August 2016: Clinical and Experimental Nephrology
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