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https://www.readbyqxmd.com/read/27806460/importance-of-comprehensive-cardiovascular-screening-in-patients-scheduled-for-kidney-donation
#1
Hala Soomro, Aisha Rasool Saand, Zaid Soomro, Mustafa Naseer, Zohaib Farrukh, Arbab Burhan Uddin Kasi, Sarah Hamid, Anika Bilal, Madiha Ahmed, Ali Raza, Tahreem Ahmad, Saif Raza, Ayyaz Alam Sultan, Rohail Jameel, Maaz Hasan Khan, Maha Begg
INTRODUCTION: End stage renal disease is on the rise in many parts of the world. Kidney transplant is a common procedure and definitive treatment for end stage renal disease. Along with its various advantages, it presents with an array of complications, associated with the procedure. Hence, an effective screening program to identify eligible donors is of crucial importance. The main aim of this study was to identify the frequency of possible undetected cardiovascular abnormalities in scheduled donors and its association with gender...
June 30, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27729571/genome-wide-association-of-ckd-progression-the-chronic-renal-insufficiency-cohort-study
#2
Afshin Parsa, Peter A Kanetsky, Rui Xiao, Jayanta Gupta, Nandita Mitra, Sophie Limou, Dawei Xie, Huichun Xu, Amanda Hyre Anderson, Akinlolu Ojo, John W Kusek, Claudia M Lora, L Lee Hamm, Jiang He, Niina Sandholm, Janina Jeff, Dominic E Raj, Carsten A Böger, Erwin Bottinger, Shabnam Salimi, Rulan S Parekh, Sharon G Adler, Carl D Langefeld, Donald W Bowden, Per-Henrik Groop, Carol Forsblom, Barry I Freedman, Michael Lipkowitz, Caroline S Fox, Cheryl A Winkler, Harold I Feldman
The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome-wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We stratified all analyses by race and subsequently, diabetes status. Single-nucleotide polymorphisms (SNPs) that surpassed a significance threshold of P<1×10(-6) for association with eGFR slope were selected as candidates for follow-up and secondarily tested for association with proteinuria and time to ESRD...
October 11, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27647852/patterns-of-estimated-glomerular-filtration-rate-decline-leading-to-end-stage-renal-disease-in-type-1-diabetes
#3
Jan Skupien, James H Warram, Adam M Smiles, Robert C Stanton, Andrzej S Krolewski
OBJECTIVE: The patterns of estimated glomerular filtration rate (eGFR) decline to end-stage renal disease (ESRD) in patients with type 1 diabetes has not been conclusively described. Decline could be linearly progressive to ESRD but with a variable rate. Conversely, decline may be linear but interrupted by periods of plateaus or improvements. RESEARCH DESIGN AND METHODS: This observational study included 364 patients with type 1 diabetes attending Joslin Clinic who developed ESRD between 1991 and 2013...
September 19, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27593903/comparing-the-gfr-estimation-equations-using-both-creatinine-and-cystatin-c-to-predict-the-long-term-renal-outcome-in-type-2-diabetic-nephropathy-patients
#4
Yu Pan, Song Jiang, Dandan Qiu, Jingsong Shi, Minlin Zhou, Yu An, Yongchun Ge, Honglang Xie, Zhihong Liu
AIMS: This study aimed to determine whether eGFRcre-cys and its slope could improve the prediction of the long-term renal outcome in patients with type 2 diabetic nephropathy (DN). METHODS: The cross-sectional and longitudinal analyses included 501 type 2DN patients from 2003 to 2009. GFR was estimated using either eGFRcre-cys or the serum creatinine-based equation (eGFRcre) or the cystatin C-based equation (eGFRcys), and was classified into 3 categories (≥90, 60-90, ≤60ml/min per 1...
November 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27557557/risk-factors-for-progression-in-children-and-young-adults-with-iga-nephropathy-an-analysis-of-261-cases-from-the-valiga-european-cohort
#5
Rosanna Coppo, Danilo Lofaro, Roberta R Camilla, Shubha Bellur, Daniel Cattran, H Terence Cook, Ian S D Roberts, Licia Peruzzi, Alessandro Amore, Francesco Emma, Laura Fuiano, Ulla Berg, Rezan Topaloglu, Yelda Bilginer, Loreto Gesualdo, Rosaria Polci, Malgorzata Mizerska-Wasiak, Yasar Caliskan, Sigrid Lundberg, Giovanni Cancarini, Colin Geddes, Jack Wetzels, Andrzej Wiecek, Magdalena Durlik, Stefano Cusinato, Cristiana Rollino, Milena Maggio, Manuel Praga, Hilde K Smerud, Vladimir Tesar, Dita Maixnerova, Jonathan Barratt, Teresa Papalia, Renzo Bonofiglio, Gianna Mazzucco, Costantinos Giannakakis, Magnus Soderberg, Diclehan Orhan, Anna Maria Di Palma, Jadwiga Maldyk, Yasemin Ozluk, Birgitta Sudelin, Regina Tardanico, David Kipgen, Eric Steenbergen, Henryk Karkoszka, Agnieszka Perkowska-Ptasinska, Franco Ferrario, Eduardo Gutierrez, Eva Honsova
BACKGROUND: There is a need for early identification of children with immunoglobulin A nephropathy (IgAN) at risk of progression of kidney disease. METHODS: Data on 261 young patients [age <23 years; mean follow-up of 4.9 (range 2.5-8.1) years] enrolled in VALIGA, a study designed to validate the Oxford Classification of IgAN, were assessed. Renal biopsies were scored for the presence of mesangial hypercellularity (M1), endocapillary hypercellularity (E1), segmental glomerulosclerosis (S1), tubular atrophy/interstitial fibrosis (T1-2) (MEST score) and crescents (C1)...
August 25, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27550651/regional-trends-in-avoidable-hospitalisations-due-to-complications-among-population-with-diabetes-in-finland-in-1996-2011-a-register-based-cohort-study
#6
Kristiina Manderbacka, Martti Arffman, Sonja Lumme, Markku Lehikoinen, Klas Winell, Ilmo Keskimäki
OBJECTIVES: Diabetes requires continuous medical care including prevention of acute complications and risk reduction for long-term complications. Diabetic complications impose a substantial burden on public health and care delivery. We examined trends in regional differences in hospitalisations due to diabetes-related complications among the total diabetes population in Finland. RESEARCH DESIGN: A longitudinal register-based cohort study 1996-2011 among a total population with diabetes in Finland...
2016: BMJ Open
https://www.readbyqxmd.com/read/27295898/-autosomal-dominant-polycystic-kidney-disease-how-and-why-should-we-identify-the-patients-rapidly-progressing-to-end-stage-renal-disease
#7
A Bodson, P Meunier, J-M Krzesinski, F Jouret
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterised by the progressive development of multiple and bilateral cysts in kidneys and other organs. Most patients with ADPKD will develop, sooner or later, end-stage renal disease (ESRD). The morbidity and mortality associated with ESRD prompt physicians to identify early ADPKD patients considered as "rapid progressors", who have the greatest risk to rapidly develop ESRD. The rate of progression can be assessed by clinical--especially with the "predicting renal outcome in polycystic kidney disease score" (PROPKD-Score)-, biological (a decline of the glomerular filtration rate (GFR) of 4...
April 2016: Revue Médicale de Liège
https://www.readbyqxmd.com/read/27242372/association-between-vascular-access-creation-and-deceleration-of-estimated-glomerular-filtration-rate-decline-in-late-stage-chronic-kidney-disease-patients-transitioning-to-end-stage-renal-disease
#8
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Vanessa A Ravel, Melissa Soohoo, Connie M Rhee, Elani Streja, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND: Prior studies have suggested that arteriovenous fistula (AVF) or graft (AVG) creation may be associated with slowing of estimated glomerular filtration rate (eGFR) decline. It is unclear if this is attributable to the physiological benefits of a mature access on systemic circulation versus confounding factors. METHODS: We examined a nationwide cohort of 3026 US veterans with advanced chronic kidney disease (CKD) transitioning to dialysis between 2007 and 2011 who had a pre-dialysis AVF/AVG and had at least three outpatient eGFR measurements both before and after AVF/AVG creation...
May 30, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27163501/pharmacokinetics-of-the-long-acting-basal-insulin-ly2605541-in-subjects-with-varying-degrees-of-renal-function
#9
Helle Linnebjerg, Siak Leng Choi, Eric Chen Quin Lam, Kenneth F Mace, Teri S Hodgson, Vikram P Sinha
The pharmacokinetics of LY2605541 (basal insulin peglispro), a novel long-acting basal insulin analogue, was evaluated in 5 groups of subjects with varying degrees of renal function based on creatinine clearance: normal renal function (>80 mL/min), mild renal impairment (51-80 mL/min), moderate renal impairment (30-50 mL/min), severe renal impairment (<30 mL/min), or end-stage renal disease (ESRD) requiring hemodialysis. Serial blood samples for pharmacokinetic analyses were collected up to 12 days following a single 0...
May 2016: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/27151925/ckd-progression-and-mortality-among-hispanics-and-non-hispanics
#10
Michael J Fischer, Jesse Y Hsu, Claudia M Lora, Ana C Ricardo, Amanda H Anderson, Lydia Bazzano, Magdalena M Cuevas, Chi-Yuan Hsu, John W Kusek, Amada Renteria, Akinlolu O Ojo, Dominic S Raj, Sylvia E Rosas, Qiang Pan, Kristine Yaffe, Alan S Go, James P Lash
Although recommended approaches to CKD management are achieved less often in Hispanics than in non-Hispanics, whether long-term outcomes differ between these groups is unclear. In a prospective longitudinal analysis of participants enrolled into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies, we used Cox proportional hazards models to determine the association between race/ethnicity, CKD progression (50% eGFR loss or incident ESRD), incident ESRD, and all-cause mortality, and linear mixed-effects models to assess differences in eGFR slope...
November 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27032886/early-change-in-urine-protein-as-a-surrogate-end-point-in-studies-of-iga-nephropathy-an-individual-patient-meta-analysis
#11
Lesley A Inker, Hasi Mondal, Tom Greene, Taylor Masaschi, Francesco Locatelli, Francesco P Schena, Ritsuko Katafuchi, Gerald B Appel, Bart D Maes, Philip K Li, Manuel Praga, Lucia Del Vecchio, Simeone Andrulli, Carlo Manno, Eduardo Gutierrez, Alex Mercer, Kevin J Carroll, Christopher H Schmid, Andrew S Levey
BACKGROUND: The role of change in proteinuria as a surrogate end point for randomized trials in immunoglobulin A nephropathy (IgAN) has previously not been thoroughly evaluated. STUDY DESIGN: Individual patient-level meta-analysis. SETTING & POPULATION: Individual-patient data for 830 patients from 11 randomized trials evaluating 4 intervention types (renin-angiotensin system [RAS] blockade, fish oil, immunosuppression, and steroids) examining associations between changes in urine protein and clinical end points at the individual and trial levels...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27031662/the-effects-of-cytotoxic-therapy-in-progressive-iga-nephropathy
#12
Jung-ho Shin, Jung Eun Lee, Ji Hyeon Park, Sharon Lim, Hye Ryoun Jang, Ghee Young Kwon, Wooseong Huh, Sin-Ho Jung, Yoon-Goo Kim, Ha Young Oh, Dae Joong Kim
BACKGROUND: IgA nephropathy (IgAN) is not always benign, and some patients at high risk of end-stage renal disease (ESRD) experience a rapid decline in renal function. This study retrospectively examined the beneficial effects of cytotoxic therapy. METHODS: We identified 102 patients with progressive IgAN despite optimal conservative management. Of these, 31 who received cytotoxic therapy and 55 who were managed conservatively were included. RESULTS: Median eGFR and urinary protein-to-creatinine ratio (uPCR) at baseline did not differ between the groups (p = 0...
2016: Annals of Medicine
https://www.readbyqxmd.com/read/26993562/childhood-albuminuria-and-chronic-kidney-disease-is-associated-with-mortality-and-end-stage-renal-disease
#13
Ching-Yuang Lin, Shiuh-Ming Huang
BACKGROUND: We do not yet fully grasp the significance of childhood albuminuria. Based on mass urinary screening (MUS) using albumin-specific dipsticks in school children, we studied the independent association of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in children with chronic kidney disease (CKD). METHODS: A prospective cohort of 5351 children with albuminuria detected by school MSU during the period 1992-1996, followed up to 2009...
August 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/26848002/association-of-slopes-of-estimated-glomerular-filtration-rate-with-post-end-stage-renal-disease-mortality-in-patients-with-advanced-chronic-kidney-disease-transitioning-to-dialysis
#14
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Jennie Jing, Vanessa A Ravel, Melissa Soohoo, Connie M Rhee, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
OBJECTIVE: To investigate the association of estimated glomerular filtration rate (eGFR) slopes before dialysis initiation with cause-specific mortality after dialysis initiation. PATIENTS AND METHODS: In this retrospective cohort study of 18,874 US veterans who had transitioned to dialysis from October 1, 2007, through September 30, 2011, we examined the association of pre-end-stage renal disease (ESRD) eGFR slopes with all-cause, cardiovascular, and infection-related mortality during the post-ESRD period over a median follow-up of 2...
February 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26724837/kidney-disease-in-adenine-phosphoribosyltransferase-deficiency
#15
Hrafnhildur Linnet Runolfsdottir, Runolfur Palsson, Inger M Agustsdottir, Olafur S Indridason, Vidar O Edvardsson
BACKGROUND: Adenine phosphoribosyltransferase (APRT) deficiency is a purine metabolism disorder causing kidney stones and chronic kidney disease (CKD). The course of nephrolithiasis and CKD has not been well characterized. The objective of this study was to examine long-term kidney outcomes in patients with APRT deficiency. STUDY DESIGN: An observational cohort study. SETTING & PARTICIPANTS: All patients enrolled in the APRT Deficiency Registry of the Rare Kidney Stone Consortium...
March 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26663437/recovery-of-renal-function-after-radical-nephrectomy-and-risk-factors-for-postoperative-severe-renal-impairment-a-japanese-multicenter-longitudinal-study
#16
Naoko Kawamura, Minato Yokoyama, Yasuhisa Fujii, Junichiro Ishioka, Noboru Numao, Yoh Matsuoka, Kazutaka Saito, Chizuru Arisawa, Tetsuo Okuno, Akira Noro, Shinji Morimoto, Kazunori Kihara
OBJECTIVES: To investigate longitudinal changes in renal function after radical nephrectomy, and to explore risk factors of postoperative severe renal impairment in a Japanese multicenter cohort. METHODS: The present retrospective study included 701 patients who had no metastasis, end-stage kidney disease or bilateral kidney cancer, who underwent radical nephrectomy and who were followed up for at least 1 year. The longitudinal change in postoperative renal function during a 10-year follow-up period was evaluated according to the presence or absence of potential risk factors including greater age, chronic kidney disease, hypertension, diabetes mellitus and cardiovascular disease...
March 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/26519376/role-of-renin-angiotensin-system-inhibitors-in-retardation-of-progression-of-end-stage-renal-failure-a-retrospective-study
#17
Tomoyuki Murakami, Tamio Iwamoto, Gen Yasuda, Michiko Taniguchi, Akira Fujiwara, Nobuhito Hirawa, Satoshi Umemura
BACKGROUND: Few studies have examined how renin-angiotensin system inhibitors (RASI) delay dialysis initiation in patients with advanced chronic kidney disease (CKD). We conducted a retrospective survey to examine this subject. METHODS: We reviewed the records of patients with advanced CKD for the 60-month period before dialysis initiation between 1990 and 2015. Patients were classified based on the decade of dialysis initiation into the 1990s, 2000s, and 2010s groups...
August 2016: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/26486355/death-end-stage-renal-disease-and-renal-function-decline-in-patients-with-diabetic-nephropathy-in-french-cohorts-of-type-1-and-type-2-diabetes
#18
Samy Hadjadj, Bertrand Cariou, Frederic Fumeron, Elise Gand, Guillaume Charpentier, Ronan Roussel, Ahmed-Amine Kasmi, Jean-François Gautier, Kammel Mohammedi, Pierre Gourdy, Pierre-Jean Saulnier, Eva Feigerlova, Michel Marre
AIMS/HYPOTHESIS: Microvascular complications are a common feature of diabetes but additional research is needed regarding diabetic nephropathy endpoints in type 1 and type 2 diabetes. METHODS: We compared 277 type 1 diabetes patients with 942 type 2 diabetes patients, with clinical proteinuria and no endstage renal disease (ESRD) at baseline, prospectively followed for death, ESRD and decline in estimated glomerular filtration rate (eGFR, all available measures)...
January 2016: Diabetologia
https://www.readbyqxmd.com/read/26475266/orally-active-prostacyclin-analogue-beraprost-sodium-in-patients-with-chronic-kidney-disease-a-randomized-double-blind-placebo-controlled-phase-ii-dose-finding-trial
#19
RANDOMIZED CONTROLLED TRIAL
Akio Koyama, Toshiro Fujita, Fumitake Gejyo, Hideki Origasa, Masanao Isono, Hajimu Kurumatani, Kiyonobu Okada, Hiroyuki Kanoh, Takashi Kiriyama, Shunsuke Yamada
BACKGROUND: Evidence increasingly points to the importance of chronic hypoxia in the tubulointerstitium as a final common pathway to end-stage renal disease (ESRD). Beraprost sodium (BPS) is an orally active prostacyclin (PGI2) analogue demonstrating prevention of the progression of chronic kidney disease (CKD) in various animal models by maintaining renal blood flow and attenuating renal ischemic condition. METHODS: This multicenter, randomized, double-blind, placebo-controlled, phase II trial was designed to determine the recommended dose of the sustained-release form of BPS (TRK-100STP 120 μg/day or 240 μg/day) in Japanese patients with CKD...
2015: BMC Nephrology
https://www.readbyqxmd.com/read/26239689/renal-replacement-therapy-purifying-efficiency-of-automated-peritoneal-dialysis-in-diabetic-versus-non-diabetic-patients
#20
Nicanor Vega-Diaz, Fayna Gonzalez-Cabrera, Silvia Marrero-Robayna, Raquel Santana-Estupiñan, Roberto Gallego-Samper, Fernando Henriquez-Palop, Patricia Perez-Borges, José Carlos Rodriguez-Perez
BACKGROUND: In order to reduce the cardiovascular risk, morbidity and mortality of peritoneal dialysis (PD), a minimal level of small-solute clearances as well as a sodium and water balance are needed. The peritoneal dialysis solutions used in combination have reduced the complications and allow for a long-time function of the peritoneal membrane, and the preservation of residual renal function (RRF) in patients on peritoneal dialysis (PD) is crucial for the maintenance of life quality and long-term survival...
2015: Journal of Clinical Medicine
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