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Slope and esrd

Yuqi Chen, Yuedong Wang
Joint modeling of longitudinal and survival data has attracted a great deal of attention. Some research has been undertaken to extend the joint model to incorporate multivariate longitudinal measurements recently. However, there is a lack of variable selection methods in the joint modeling of multivariate longitudinal measurements and survival time. In this article, we develop penalized likelihood methods for the selection of longitudinal features in the survival submodel. A multivariate linear mixed effect model is used to model multiple longitudinal processes where random intercepts and slopes serve as essential features of the trajectories...
July 14, 2017: Statistics in Medicine
Kenneth A Earle, Lauren Ng, Sarah White, Karima Zitouni
BACKGROUND: Recent data suggest that the higher risk of end-stage renal disease in women compared with men is associated with waist circumference. We investigated whether vascular stiffness which is linked to visceral fat accumulation is gender specific and associated with a loss in renal function. METHODS: We studied 166 patients with type 2 diabetes at high risk of progressive renal disease. A vascular stiffness index was derived from measurement of the peripheral arterial pulse waveform using infrared finger photoplethysmography...
July 2017: Diabetes & Vascular Disease Research
Szu-Chia Chen, Mei-Yueh Lee, Jiun-Chi Huang, Hsiu-Chin Mai, Po-Lin Kuo, Jer-Ming Chang, Hung-Chun Chen, Yi-Hsin Yang
Peripheral artery occlusive disease is common among diabetes mellitus (DM) and end-stage renal disease patients, and tends to progress faster and lead to worse outcomes. This study compared the association of DM with the decline in ankle-brachial index (ABI) among patients on hemodialysis (HD). This was a longitudinal analysis of ABI in HD patients from 2009 to 2015. Medical records and yearly ABI values were obtained. A longitudinal mixed-model analysis was used to evaluate ABI changing trends while accounting for within-patients correlation...
2017: PloS One
Andrzej S Krolewski, Jan Skupien, Peter Rossing, James H Warram
A new model of diabetic nephropathy in type 1 diabetes emerged from our studies of Joslin Clinic patients. The dominant feature is progressive renal decline, not albuminuria. This decline is a unidirectional process commencing while patients have normal renal function and, in the majority, progressing steadily (linearly) to end-stage renal disease (ESRD). While an individual's rate of renal decline is constant, the estimated glomerular filtration rate (eGFR) slope varies widely among individuals from -72 to -3...
June 2017: Kidney International
Soichiro Suzuki, Takeshi Nishijima, Yohei Kawasaki, Takuma Kurosawa, Yoshikazu Mutoh, Yoshimi Kikuchi, Hiroyuki Gatanaga, Shinichi Oka
Little evidence is available for the incidence of chronic kidney disease (CKD) and rate of estimated glomerular filtration rate (eGFR) decrement among Asians with low body weight who are susceptible to tenofovir disoproxil fumarate (TDF) nephrotoxicity. In this 12-year observational cohort in Tokyo, we examined 1383 treatment-naïve HIV-1-infected Asians [720 started TDF-containing (TDF group) and 663 started non-TDF-containing (control) combination antiretroviral therapy (cART)]. The CKD incidence was calculated, and the effect of TDF use on CKD development was estimated using logistic regression...
March 2017: AIDS Patient Care and STDs
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Kunihiro Matsushita, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
Constipation is one of the most prevalent conditions in primary care settings and increases the risk of cardiovascular disease, potentially through processes mediated by altered gut microbiota. However, little is known about the association of constipation with CKD. In a nationwide cohort of 3,504,732 United States veterans with an eGFR ≥60 ml/min per 1.73 m(2), we examined the association of constipation status and severity (absent, mild, or moderate/severe), defined using diagnostic codes and laxative use, with incident CKD, incident ESRD, and change in eGFR in Cox models (for time-to-event analyses) and multinomial logistic regression models (for change in eGFR)...
April 2017: Journal of the American Society of Nephrology: JASN
Monika A Niewczas, Anna V Mathew, Stephanie Croall, Jaeman Byun, Melissa Major, Venkatta S Sabisetti, Adam Smiles, Joseph V Bonventre, Subramaniam Pennathur, Andrzej S Krolewski
OBJECTIVE: Patients with type 1 diabetes (T1D) with impaired renal function are at increased risk for end-stage renal disease (ESRD). Although the rate of progression varies, determinants and mechanisms of this variation are unknown. RESEARCH DESIGN AND METHODS: We examined serum metabolomic profiles associated with variation in renal function decline in participants with T1D (the Joslin Kidney Study prospective cohort). One hundred fifty-eight patients with proteinuria and chronic kidney disease stage 3 were followed for a median of 11 years to determine estimated glomerular filtration rate slopes from serial measurements of serum creatinine and to ascertain time to onset of ESRD...
March 2017: Diabetes Care
Hala Soomro, Aisha Rasool Saand, Zaid Soomro, Mustafa Naseer, Zohaib Farrukh, Arbab Burhan Uddin Kasi, Sarah Hamid, Anika Bilal, Madiha Ahmed, Ali Raza, Tahreem Ahmad, Saif Raza, Ayyaz Alam Sultan, Rohail Jameel, Maaz Hasan Khan, Maha Begg
INTRODUCTION: End stage renal disease is on the rise in many parts of the world. Kidney transplant is a common procedure and definitive treatment for end stage renal disease. Along with its various advantages, it presents with an array of complications, associated with the procedure. Hence, an effective screening program to identify eligible donors is of crucial importance. The main aim of this study was to identify the frequency of possible undetected cardiovascular abnormalities in scheduled donors and its association with gender...
June 30, 2016: Global Journal of Health Science
Afshin Parsa, Peter A Kanetsky, Rui Xiao, Jayanta Gupta, Nandita Mitra, Sophie Limou, Dawei Xie, Huichun Xu, Amanda Hyre Anderson, Akinlolu Ojo, John W Kusek, Claudia M Lora, L Lee Hamm, Jiang He, Niina Sandholm, Janina Jeff, Dominic E Raj, Carsten A Böger, Erwin Bottinger, Shabnam Salimi, Rulan S Parekh, Sharon G Adler, Carl D Langefeld, Donald W Bowden, Per-Henrik Groop, Carol Forsblom, Barry I Freedman, Michael Lipkowitz, Caroline S Fox, Cheryl A Winkler, Harold I Feldman
The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome-wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We stratified all analyses by race and subsequently, diabetes status. Single-nucleotide polymorphisms (SNPs) that surpassed a significance threshold of P<1×10(-6) for association with eGFR slope were selected as candidates for follow-up and secondarily tested for association with proteinuria and time to ESRD...
March 2017: Journal of the American Society of Nephrology: JASN
Jan Skupien, James H Warram, Adam M Smiles, Robert C Stanton, Andrzej S Krolewski
OBJECTIVE: The patterns of estimated glomerular filtration rate (eGFR) decline to end-stage renal disease (ESRD) in patients with type 1 diabetes has not been conclusively described. Decline could be linearly progressive to ESRD but with a variable rate. Conversely, decline may be linear but interrupted by periods of plateaus or improvements. RESEARCH DESIGN AND METHODS: This observational study included 364 patients with type 1 diabetes attending the Joslin Clinic who developed ESRD between 1991 and 2013...
December 2016: Diabetes Care
Yu Pan, Song Jiang, Dandan Qiu, Jingsong Shi, Minlin Zhou, Yu An, Yongchun Ge, Honglang Xie, Zhihong Liu
AIMS: This study aimed to determine whether eGFRcre-cys and its slope could improve the prediction of the long-term renal outcome in patients with type 2 diabetic nephropathy (DN). METHODS: The cross-sectional and longitudinal analyses included 501 type 2DN patients from 2003 to 2009. GFR was estimated using either eGFRcre-cys or the serum creatinine-based equation (eGFRcre) or the cystatin C-based equation (eGFRcys), and was classified into 3 categories (≥90, 60-90, ≤60ml/min per 1...
November 2016: Journal of Diabetes and its Complications
Rosanna Coppo, Danilo Lofaro, Roberta R Camilla, Shubha Bellur, Daniel Cattran, H Terence Cook, Ian S D Roberts, Licia Peruzzi, Alessandro Amore, Francesco Emma, Laura Fuiano, Ulla Berg, Rezan Topaloglu, Yelda Bilginer, Loreto Gesualdo, Rosaria Polci, Malgorzata Mizerska-Wasiak, Yasar Caliskan, Sigrid Lundberg, Giovanni Cancarini, Colin Geddes, Jack Wetzels, Andrzej Wiecek, Magdalena Durlik, Stefano Cusinato, Cristiana Rollino, Milena Maggio, Manuel Praga, Hilde K Smerud, Vladimir Tesar, Dita Maixnerova, Jonathan Barratt, Teresa Papalia, Renzo Bonofiglio, Gianna Mazzucco, Costantinos Giannakakis, Magnus Soderberg, Diclehan Orhan, Anna Maria Di Palma, Jadwiga Maldyk, Yasemin Ozluk, Birgitta Sudelin, Regina Tardanico, David Kipgen, Eric Steenbergen, Henryk Karkoszka, Agnieszka Perkowska-Ptasinska, Franco Ferrario, Eduardo Gutierrez, Eva Honsova
BACKGROUND: There is a need for early identification of children with immunoglobulin A nephropathy (IgAN) at risk of progression of kidney disease. METHODS: Data on 261 young patients [age <23 years; mean follow-up of 4.9 (range 2.5-8.1) years] enrolled in VALIGA, a study designed to validate the Oxford Classification of IgAN, were assessed. Renal biopsies were scored for the presence of mesangial hypercellularity (M1), endocapillary hypercellularity (E1), segmental glomerulosclerosis (S1), tubular atrophy/interstitial fibrosis (T1-2) (MEST score) and crescents (C1)...
January 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Kristiina Manderbacka, Martti Arffman, Sonja Lumme, Markku Lehikoinen, Klas Winell, Ilmo Keskimäki
OBJECTIVES: Diabetes requires continuous medical care including prevention of acute complications and risk reduction for long-term complications. Diabetic complications impose a substantial burden on public health and care delivery. We examined trends in regional differences in hospitalisations due to diabetes-related complications among the total diabetes population in Finland. RESEARCH DESIGN: A longitudinal register-based cohort study 1996-2011 among a total population with diabetes in Finland...
2016: BMJ Open
A Bodson, P Meunier, J-M Krzesinski, F Jouret
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterised by the progressive development of multiple and bilateral cysts in kidneys and other organs. Most patients with ADPKD will develop, sooner or later, end-stage renal disease (ESRD). The morbidity and mortality associated with ESRD prompt physicians to identify early ADPKD patients considered as "rapid progressors", who have the greatest risk to rapidly develop ESRD. The rate of progression can be assessed by clinical--especially with the "predicting renal outcome in polycystic kidney disease score" (PROPKD-Score)-, biological (a decline of the glomerular filtration rate (GFR) of 4...
April 2016: Revue Médicale de Liège
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Vanessa A Ravel, Melissa Soohoo, Connie M Rhee, Elani Streja, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
BACKGROUND: Prior studies have suggested that arteriovenous fistula (AVF) or graft (AVG) creation may be associated with slowing of estimated glomerular filtration rate (eGFR) decline. It is unclear if this is attributable to the physiological benefits of a mature access on systemic circulation versus confounding factors. METHODS: We examined a nationwide cohort of 3026 US veterans with advanced chronic kidney disease (CKD) transitioning to dialysis between 2007 and 2011 who had a pre-dialysis AVF/AVG and had at least three outpatient eGFR measurements both before and after AVF/AVG creation...
May 30, 2016: Nephrology, Dialysis, Transplantation
Helle Linnebjerg, Siak Leng Choi, Eric Chen Quin Lam, Kenneth F Mace, Teri S Hodgson, Vikram P Sinha
The pharmacokinetics of LY2605541 (basal insulin peglispro), a novel long-acting basal insulin analogue, was evaluated in 5 groups of subjects with varying degrees of renal function based on creatinine clearance: normal renal function (>80 mL/min), mild renal impairment (51-80 mL/min), moderate renal impairment (30-50 mL/min), severe renal impairment (<30 mL/min), or end-stage renal disease (ESRD) requiring hemodialysis. Serial blood samples for pharmacokinetic analyses were collected up to 12 days following a single 0...
May 2016: Clinical Pharmacology in Drug Development
Michael J Fischer, Jesse Y Hsu, Claudia M Lora, Ana C Ricardo, Amanda H Anderson, Lydia Bazzano, Magdalena M Cuevas, Chi-Yuan Hsu, John W Kusek, Amada Renteria, Akinlolu O Ojo, Dominic S Raj, Sylvia E Rosas, Qiang Pan, Kristine Yaffe, Alan S Go, James P Lash
Although recommended approaches to CKD management are achieved less often in Hispanics than in non-Hispanics, whether long-term outcomes differ between these groups is unclear. In a prospective longitudinal analysis of participants enrolled into the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC Studies, we used Cox proportional hazards models to determine the association between race/ethnicity, CKD progression (50% eGFR loss or incident ESRD), incident ESRD, and all-cause mortality, and linear mixed-effects models to assess differences in eGFR slope...
November 2016: Journal of the American Society of Nephrology: JASN
Lesley A Inker, Hasi Mondal, Tom Greene, Taylor Masaschi, Francesco Locatelli, Francesco P Schena, Ritsuko Katafuchi, Gerald B Appel, Bart D Maes, Philip K Li, Manuel Praga, Lucia Del Vecchio, Simeone Andrulli, Carlo Manno, Eduardo Gutierrez, Alex Mercer, Kevin J Carroll, Christopher H Schmid, Andrew S Levey
BACKGROUND: The role of change in proteinuria as a surrogate end point for randomized trials in immunoglobulin A nephropathy (IgAN) has previously not been thoroughly evaluated. STUDY DESIGN: Individual patient-level meta-analysis. SETTING & POPULATION: Individual-patient data for 830 patients from 11 randomized trials evaluating 4 intervention types (renin-angiotensin system [RAS] blockade, fish oil, immunosuppression, and steroids) examining associations between changes in urine protein and clinical end points at the individual and trial levels...
September 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jung-ho Shin, Jung Eun Lee, Ji Hyeon Park, Sharon Lim, Hye Ryoun Jang, Ghee Young Kwon, Wooseong Huh, Sin-Ho Jung, Yoon-Goo Kim, Ha Young Oh, Dae Joong Kim
BACKGROUND: IgA nephropathy (IgAN) is not always benign, and some patients at high risk of end-stage renal disease (ESRD) experience a rapid decline in renal function. This study retrospectively examined the beneficial effects of cytotoxic therapy. METHODS: We identified 102 patients with progressive IgAN despite optimal conservative management. Of these, 31 who received cytotoxic therapy and 55 who were managed conservatively were included. RESULTS: Median eGFR and urinary protein-to-creatinine ratio (uPCR) at baseline did not differ between the groups (p = 0...
2016: Annals of Medicine
Ching-Yuang Lin, Shiuh-Ming Huang
BACKGROUND: We do not yet fully grasp the significance of childhood albuminuria. Based on mass urinary screening (MUS) using albumin-specific dipsticks in school children, we studied the independent association of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD) in children with chronic kidney disease (CKD). METHODS: A prospective cohort of 5351 children with albuminuria detected by school MSU during the period 1992-1996, followed up to 2009...
August 2016: Pediatrics and Neonatology
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