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https://www.readbyqxmd.com/read/28727739/survival-analysis-of-heart-failure-patients-a-case-study
#1
Tanvir Ahmad, Assia Munir, Sajjad Haider Bhatti, Muhammad Aftab, Muhammad Ali Raza
This study was focused on survival analysis of heart failure patients who were admitted to Institute of Cardiology and Allied hospital Faisalabad-Pakistan during April-December (2015). All the patients were aged 40 years or above, having left ventricular systolic dysfunction, belonging to NYHA class III and IV. Cox regression was used to model mortality considering age, ejection fraction, serum creatinine, serum sodium, anemia, platelets, creatinine phosphokinase, blood pressure, gender, diabetes and smoking status as potentially contributing for mortality...
2017: PloS One
https://www.readbyqxmd.com/read/28700482/beneficial-effects-of-fu-zheng-qu-zhuo-oral-liquid-combined-with-standard-integrated-therapy-in-patients-with-chronic-kidney-disease-stage-3-4-a-randomized-placebo-controlled-clinical-trial
#2
Shen Li, Xiang-Rong Rao, Xi-Wen Dai, Kun Pei, Lee Wang, Bao-Min Huo, Xiu-Juan Wang, Ling-Xin Kong, Nan-Nan Zhang, Feng-Mei Lian
BACKGROUND: The high worldwide prevalence of chronic kidney disease (CKD) is a critical health problem and the development of more effective therapies is urgently needed. We conducted a randomized, double-blinded, placebo-controlled clinical trial from October 2010 to December 2012 to assess whether Fu-Zheng-Qu-Zhuo oral liquid (FZQZ) has a beneficial effect in preventing CKD progression when added to standard integrated therapies. METHODS: Patients with CKD stage 3 to 4 from 3 hospitals in Beijing, China were enrolled...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28621156/pilot-study-use-of-contrast-enhanced-ultrasonography-in-feline-renal-transplant-recipients
#3
Esther H Greenbarg, David A Jiménez, Lucas A Nell, Chad W Schmiedt
Objectives The study aims were to evaluate the feasibility of contrast-enhanced ultrasonography in feline renal transplant recipients in the post-transplantation period and to report findings in a case with presumptive delayed allograft ischemia. Methods Cats were imaged postoperatively using contrast harmonic ultrasonography after a bolus injection of a microbubble contrast medium. Time/mean pixel intensity curves were generated for cortical and medullary regions of interest in the renal allograft in each cat...
June 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28614813/polycystic-kidney-disease-and-the-vasopressin-pathway
#4
Maatje D A van Gastel, Vicente E Torres
Vasopressin, also known as arginine vasopressin or antidiuretic hormone, plays a pivotal role in maintaining body homeostasis. Increased vasopressin concentrations, measured by its surrogate copeptin, have been associated with disease severity as well as disease progression in polycystic kidney disease (PKD), and in experimental studies vasopressin has been shown to directly regulate cyst growth. Blocking vasopressin effects on the kidney via the vasopressin V2-receptor and lower circulating vasopressin concentration are potential treatment opportunities that have been the subject of study in PKD in recent years...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28556931/quantification-of-carbamylated-albumin-in-serum-based-on-capillary-electrophoresis
#5
Sigurd Delanghe, Alena Moerman, Anneleen Pletinck, Eva Schepers, Griet Glorieux, Wim Van Biesen, Joris R Delanghe, Marijn M Speeckaert
Protein carbamylation, a nonenzymatic posttranslational modification promoted during uremia, is linked to a poor prognosis. In the present study, carbamylation of serum albumin was assayed using the symmetry factor on a capillary electrophoresis instrument (Helena V8). The symmetry factor has been defined as the distance from the center line of the peak to the back slope, divided by the distance from the center line of the peak to the front slope, with all measurements made at 10% of the maximum peak height...
May 30, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28547774/population-pharmacokinetics-pharmacodynamics-and-exploratory-exposure-response-analyses-of-apixaban-in-subjects-treated-for-venous-thromboembolism
#6
W Byon, K Sweeney, C Frost, R A Boyd
Apixaban is approved for treatment of venous thromboembolism (VTE) and prevention of recurrence. Population pharmacokinetics, pharmacokinetics-pharmacodynamics (anti-FXa activity), and exposure-response (binary bleeding and thromboembolic endpoints) of apixaban in VTE treatment subjects were characterized using data from phase I-III studies. Apixaban pharmacokinetics were adequately characterized by a two-compartment model with first-order absorption and elimination. Age, sex, and Asian race had less than 25% impact on exposure, while subjects with severe renal impairment were predicted to have 56% higher exposure than the reference subject (60-year-old non-Asian male weighing 85 kg with creatinine clearance of 100 mL/min)...
May 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28445881/absence-of-decline-of-kidney-function-in-human-immunodeficiency-virus-infected-patients-under-routine-clinical-management
#7
Julie Boucquemont, Sylvie Lawson-Ayayi, Claire Rigothier, Fabrice Bonnet, Cécile Proust-Lima, Didier Neau, Carine Greib, Ghada Miremont-Salamé, François Dabis, Michel Dupon, Frédéric-Antoine Dauchy
BACKGROUND: Since the introduction of antiretroviral therapy (ART), human immunodeficiency virus (HIV)-infected patients have a drastically improved prognosis but at the same time they are also more affected by non-HIV related complications, such as chronic kidney disease. The objective of our study was to investigate the effect of proteinuria and tenofovir (TDF)-containing ART regimens on the temporal evolution of estimated glomerular filtration rate (eGFR). METHODS: Between April 2008 and October 2012, we enrolled 395 patients with a complete renal evaluation among patients from the ANRS C03 Aquitaine cohort, a prospective hospital-based cohort of HIV-1-infected patients under routine clinical management in southwestern France...
2017: Nephron
https://www.readbyqxmd.com/read/28412995/development-and-validation-of-prediction-models-for-risks-of-complications-in-early-onset-pre-eclampsia-prep-a-prospective-cohort-study
#8
Shakila Thangaratinam, John Allotey, Nadine Marlin, Ben W Mol, Peter Von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Asif Ahmed, Jane Daniels, Jon Deeks, Khaled Ismail, Ann Marie Barnard, Julie Dodds, Sally Kerry, Carl Moons, Richard D Riley, Khalid S Khan
BACKGROUND: The prognosis of early-onset pre-eclampsia (before 34 weeks' gestation) is variable. Accurate prediction of complications is required to plan appropriate management in high-risk women. OBJECTIVE: To develop and validate prediction models for outcomes in early-onset pre-eclampsia. DESIGN: Prospective cohort for model development, with validation in two external data sets. SETTING: Model development: 53 obstetric units in the UK...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28406941/association-of-diabetes-mellitus-with-decline-in-ankle-brachial-index-among-patients-on-hemodialysis-a-6-year-follow-up-study
#9
COMPARATIVE STUDY
Szu-Chia Chen, Mei-Yueh Lee, Jiun-Chi Huang, Hsiu-Chin Mai, Po-Lin Kuo, Jer-Ming Chang, Hung-Chun Chen, Yi-Hsin Yang
Peripheral artery occlusive disease is common among diabetes mellitus (DM) and end-stage renal disease patients, and tends to progress faster and lead to worse outcomes. This study compared the association of DM with the decline in ankle-brachial index (ABI) among patients on hemodialysis (HD). This was a longitudinal analysis of ABI in HD patients from 2009 to 2015. Medical records and yearly ABI values were obtained. A longitudinal mixed-model analysis was used to evaluate ABI changing trends while accounting for within-patients correlation...
2017: PloS One
https://www.readbyqxmd.com/read/28356664/comparison-of-serum-creatinine-based-estimating-equations-with-gates-protocol-for-predicting-glomerular-filtration-rate-in-indian-population
#10
A V Mulay, S M Gokhale
In clinical practice, serum creatinine-based predicting equations and Gates protocol based on gamma camera imaging of kidneys after injection of Tc99m-diethylenetriaminepentaacetic acid (DTPA) are commonly used to assess glomerular filtration rate (GFR). Comparison of these methods, especially the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation with gold standard method of assessment of GFR by plasma clearance of Tc-99mDTPA is not well-studied in Indian population. We conducted this study to compare GFR estimation by gamma camera-based Gates protocol and serum creatinine-based predicting equations with GFR measured by plasma clearance of Tc-99mDTPA...
March 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28356148/prediction-of-complications-in-early-onset-pre-eclampsia-prep-development-and-external-multinational-validation-of-prognostic-models
#11
Shakila Thangaratinam, John Allotey, Nadine Marlin, Julie Dodds, Fiona Cheong-See, Peter von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Sally Kerry, Ben W Mol, Karl G M Moons, Richard D Riley, Khalid S Khan
BACKGROUND: Unexpected clinical deterioration before 34 weeks gestation is an undesired course in early-onset pre-eclampsia. To safely prolong preterm gestation, accurate and timely prediction of complications is required. METHOD: Women with confirmed early onset pre-eclampsia were recruited from 53 maternity units in the UK to a large prospective cohort study (PREP-946) for development of prognostic models for the overall risk of experiencing a complication using logistic regression (PREP-L), and for predicting the time to adverse maternal outcome using a survival model (PREP-S)...
March 30, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28332956/high-urinary-aspartate-aminotransferase-in-the-late-posttransplant-period-predicts-rapid-progressive-decline-in-kidney-allograft-function
#12
Andriy V Trailin, Marina V Pleten, Tatiana I Ostapenko, Nadia F Iefimenko, Olexander S Nikonenko
OBJECTIVES: Scant information is available on factors for predicting the rate of decline in kidney allograft function beyond 1 year posttransplant.We investigated whether urinary enzymes (alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, N-acetyl-β-D-hexosaminidase, and ε-glutamyl transpeptidase) in the late postoperative period can predict the decline in estimated glomerular filtration rate. MATERIALS AND METHODS: In 79 kidney allograft recipients 1 to 17 years after kidney transplant, we assessed a value of urinary enzymes single measurement for predicting the slope of estimated glomerular filtration rate, rapid decline in estimated glomerular filtration rate (> 5 mL/min/1...
June 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28317454/comparison-of-methods-for-estimating-glomerular-filtration-rate-in-head-and-neck-cancer-patients-treated-with-cisplatin
#13
Lotte Lindberg, Kasper Brødbæk, Erik G Hägerström, Jens Bentzen, Bent Kristensen, Bo Zerahn
Cisplatin is a chemotherapeutic agent widely used in the treatment of various solid tumors. Cisplatin induces nephrotoxicity and may lead to long-term reduction of kidney function. Consequently, determination of glomerular filtration rate (GFR) is used to monitor potential kidney damage. This study aimed to compare two commonly used algorithms for estimating GFR (eGFR) from plasma creatinine (PCr) with (51)Cr-EDTA clearance (CrCl) as a reference method. This was a retrospective single center study of 94 head and neck cancer patients treated with cisplatin...
March 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28164498/method-comparison-and-bias-estimation-of-blood-urea-nitrogen-bun-creatinine-cr-and-uric-acid-ua-measurements-between-two-analytical-methods
#14
Anji Cai, Suwen Qi, Zhuowa Su, Yu Yang, Huaqing Shen, Tianyuan Wang, Yong Dai
BACKGROUND: A comparison of any two methods is of great importance in a clinical laboratory. In this study, our aim is to compare the assay results of blood urea nitrogen (BUN), creatinine (Cr), and uric acid (UA) obtained through two distinct methods and then assess the analytical agreement of the two methods. METHODS: A test method (Vitros5600 system) measuring BUN, Cr, and UA analytes was compared with a reference method (Hitachi7600 system). The Clinical and Laboratory Standards Institute (CLSI) document EP9-A2 guidelines were followed to evaluate the method comparison and bias using 40 patient samples...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28154020/comparison-of-performance-of-improved-serum-estimators-of-glomerular-filtration-rate-gfr-to-99m-tc-dtpa-gfr-methods-in-patients-with-hepatic-cirrhosis
#15
COMPARATIVE STUDY
Zaid Haddadin, Vivian Lee, Christopher Conlin, Lei Zhang, Kristi Carlston, Glen Morrell, Daniel Kim, John M Hoffman, Kathryn Morton
Glomerular filtration rate (GFR) measurements are critical in patients with hepatic cirrhosis but potentially erroneous when based on serum creatinine. New equations for estimated GFR (eGFR) have shown variable performance in cirrhotics, possibly because of inaccuracies in reference methods for measured GFR (mGFR). The primary objective was to compare the performance of 4 improved eGFR equations with a 1-compartment, 2-sample plasma slope intercept (99m)Tc-DTPA mGFR method to determine whether any of the eGFR calculations could replace plasma (99m)Tc-DTPA mGFR in patients with cirrhosis...
March 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28087576/circulating-modified-metabolites-and-a-risk-of-esrd-in-patients-with-type-1-diabetes-and-chronic-kidney-disease
#16
Monika A Niewczas, Anna V Mathew, Stephanie Croall, Jaeman Byun, Melissa Major, Venkatta S Sabisetti, Adam Smiles, Joseph V Bonventre, Subramaniam Pennathur, Andrzej S Krolewski
OBJECTIVE: Patients with type 1 diabetes (T1D) with impaired renal function are at increased risk for end-stage renal disease (ESRD). Although the rate of progression varies, determinants and mechanisms of this variation are unknown. RESEARCH DESIGN AND METHODS: We examined serum metabolomic profiles associated with variation in renal function decline in participants with T1D (the Joslin Kidney Study prospective cohort). One hundred fifty-eight patients with proteinuria and chronic kidney disease stage 3 were followed for a median of 11 years to determine estimated glomerular filtration rate slopes from serial measurements of serum creatinine and to ascertain time to onset of ESRD...
March 2017: Diabetes Care
https://www.readbyqxmd.com/read/27998909/association-of-circulating-biomarkers-adrenomedullin-tnfr1-and-nt-probnp-with-renal-function-decline-in-patients-with-type-2-diabetes-a-french-prospective-cohort
#17
Pierre-Jean Saulnier, Elise Gand, Gilberto Velho, Kamel Mohammedi, Philippe Zaoui, Mathilde Fraty, Jean Michel Halimi, Ronan Roussel, Stéphanie Ragot, Samy Hadjadj
OBJECTIVE: We explored the prognostic value of three circulating candidate biomarkers-midregional-proadrenomedullin (MR-proADM), soluble tumor necrosis factor receptor 1 (sTNFR1), and N-terminal prohormone brain natriuretic peptide (NT-proBNP)-for change in renal function in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: Outcomes were defined as renal function loss (RFL), ≥40% decline of estimated glomerular filtration rate (eGFR) from baseline, and rapid renal function decline (RRFD), absolute annual eGFR slope <-5 mL/min/year...
December 20, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27986873/long-term-cortisol-measures-predict-alzheimer-disease-risk
#18
Gilda E Ennis, Yang An, Susan M Resnick, Luigi Ferrucci, Richard J O'Brien, Scott D Moffat
OBJECTIVE: To examine whether long-term measures of cortisol predict Alzheimer disease (AD) risk. METHOD: We used a prospective longitudinal design to examine whether cortisol dysregulation was related to AD risk. Participants were from the Baltimore Longitudinal Study of Aging (BLSA) and submitted multiple 24-hour urine samples over an average interval of 10.56 years. Urinary free cortisol (UFC) and creatinine (Cr) were measured, and a UFC/Cr ratio was calculated to standardize UFC...
January 24, 2017: Neurology
https://www.readbyqxmd.com/read/27943221/a-population-pharmacokinetic-model-for-51-cr-edta-to-estimate-renal-function
#19
Isabelle H S Kuan, Stephen B Duffull, Tracey L Putt, John B W Schollum, Robert J Walker, Daniel F B Wright
BACKGROUND AND OBJECTIVES: (51)Cr EDTA clearance (CL) from plasma is used to estimate glomerular filtration rate (GFR). We propose that current methods for analysing the raw (51)Cr EDTA measurements over-simplifies the disposition of (51)Cr EDTA and therefore could produce biased GFR estimates. The aim of this study was to develop a population pharmacokinetic model for (51)Cr EDTA disposition and to compare model-predicted GFR to other methods of estimating renal function. PATIENTS AND METHODS: Data from 40 individuals who received ~7...
June 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/27906832/clinical-validation-of-simultaneous-analysis-of-tacrolimus-cyclosporine-a-and-creatinine-in-dried-blood-spots-in-kidney-transplant-patients
#20
Herman Veenhof, Remco A Koster, Jan-Willem C Alffenaar, Stefan P Berger, Stephan J L Bakker, Daan J Touw
BACKGROUND: Monitoring of creatinine and immunosuppressive drug concentrations, such as tacrolimus (TaC) and cyclosporin A (CsA), is important in the outpatient follow-up of kidney transplant recipients. Monitoring by dried blood spot (DBS) provides patients the opportunity to sample a drop of blood from a fingerprick at home, which can be sent to the laboratory by mail. METHODS: We performed a clinical validation in which we compared measurements from whole-blood samples obtained by venapuncture with measurements from DBS samples simultaneously obtained by fingerprick...
July 2017: Transplantation
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