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Dna migration ancestry

Scarlett Marshall, Ranajit Das, Mehdi Pirooznia, Eran Elhaik
The Druze are an aggregate of communities in the Levant and Near East living almost exclusively in the mountains of Syria, Lebanon and Israel whose ~1000 year old religion formally opposes mixed marriages and conversions. Despite increasing interest in genetics of the population structure of the Druze, their population history remains unknown. We investigated the genetic relationships between Israeli Druze and both modern and ancient populations. We evaluated our findings in light of three hypotheses purporting to explain Druze history that posit Arabian, Persian or mixed Near Eastern-Levantine roots...
November 16, 2016: Scientific Reports
Aranka Csősz, Anna Szécsényi-Nagy, Veronika Csákyová, Péter Langó, Viktória Bódis, Kitti Köhler, Gyöngyvér Tömöry, Melinda Nagy, Balázs Gusztáv Mende
The ancient Hungarians originated from the Ural region in today's central Russia and migrated across the Eastern European steppe, according to historical sources. The Hungarians conquered the Carpathian Basin 895-907 AD, and admixed with the indigenous communities. Here we present mitochondrial DNA results from three datasets: one from the Avar period (7(th)-9(th) centuries) of the Carpathian Basin (n = 31); one from the Hungarian conquest-period (n = 76); and a completion of the published 10(th)-12(th) century Hungarian-Slavic contact zone dataset by four samples...
2016: Scientific Reports
Pontus Skoglund, David Reich
Whole-genome studies have documented that most Native American ancestry stems from a single population that diversified within the continent more than twelve thousand years ago. However, this shared ancestry hides a more complex history whereby at least four distinct streams of Eurasian migration have contributed to present-day and prehistoric Native American populations. Whole genome studies enhanced by technological breakthroughs in ancient DNA now provide evidence of a sequence of events involving initial migrations from a structured Northeast Asian source population with differential relatedness to present-day Australasian populations, followed by a divergence into northern and southern Native American lineages...
December 2016: Current Opinion in Genetics & Development
Vasili Pankratov, Sergei Litvinov, Alexei Kassian, Dzmitry Shulhin, Lieve Tchebotarev, Bayazit Yunusbayev, Märt Möls, Hovhannes Sahakyan, Levon Yepiskoposyan, Siiri Rootsi, Ene Metspalu, Maria Golubenko, Natalia Ekomasova, Farida Akhatova, Elza Khusnutdinova, Evelyne Heyer, Phillip Endicott, Miroslava Derenko, Boris Malyarchuk, Mait Metspalu, Oleg Davydenko, Richard Villems, Alena Kushniarevich
Medieval era encounters of nomadic groups of the Eurasian Steppe and largely sedentary East Europeans had a variety of demographic and cultural consequences. Amongst these outcomes was the emergence of the Lipka Tatars-a Slavic-speaking Sunni-Muslim minority residing in modern Belarus, Lithuania and Poland, whose ancestors arrived in these territories via several migration waves, mainly from the Golden Horde. Our results show that Belarusian Lipka Tatars share a substantial part of their gene pool with Europeans as indicated by their Y-chromosomal, mitochondrial and autosomal DNA variation...
2016: Scientific Reports
N Akbar, H Ahmad, M S Nadeem, B E Hemphill, K Muhammad, W Ahmad, M Ilyas
Mitochondrial DNA (mtDNA) is an important tool used to explore ethnogenetics and the evolutionary history of human populations. In this study, hypervariable segment I (HVSI) from mtDNA was analyzed to establish the genetic lineage of the Hazarewal populations residing in the Mansehra and Abbottabad districts of Northern Pakistan. HVSI was extracted from genetic specimens obtained from 225 unrelated male and female individuals belonging to seven distinct Pakistani ethnic groups (31 Abbassis, 44 Awans, 38 Gujars, 16 Jadoons, 23 Karlals, 33 Syeds, and 40 Tanolis)...
June 24, 2016: Genetics and Molecular Research: GMR
Qiaomei Fu, Cosimo Posth, Mateja Hajdinjak, Martin Petr, Swapan Mallick, Daniel Fernandes, Anja Furtwängler, Wolfgang Haak, Matthias Meyer, Alissa Mittnik, Birgit Nickel, Alexander Peltzer, Nadin Rohland, Viviane Slon, Sahra Talamo, Iosif Lazaridis, Mark Lipson, Iain Mathieson, Stephan Schiffels, Pontus Skoglund, Anatoly P Derevianko, Nikolai Drozdov, Vyacheslav Slavinsky, Alexander Tsybankov, Renata Grifoni Cremonesi, Francesco Mallegni, Bernard Gély, Eligio Vacca, Manuel R González Morales, Lawrence G Straus, Christine Neugebauer-Maresch, Maria Teschler-Nicola, Silviu Constantin, Oana Teodora Moldovan, Stefano Benazzi, Marco Peresani, Donato Coppola, Martina Lari, Stefano Ricci, Annamaria Ronchitelli, Frédérique Valentin, Corinne Thevenet, Kurt Wehrberger, Dan Grigorescu, Hélène Rougier, Isabelle Crevecoeur, Damien Flas, Patrick Semal, Marcello A Mannino, Christophe Cupillard, Hervé Bocherens, Nicholas J Conard, Katerina Harvati, Vyacheslav Moiseyev, Dorothée G Drucker, Jiří Svoboda, Michael P Richards, David Caramelli, Ron Pinhasi, Janet Kelso, Nick Patterson, Johannes Krause, Svante Pääbo, David Reich
Modern humans arrived in Europe ~45,000 years ago, but little is known about their genetic composition before the start of farming ~8,500 years ago. Here we analyse genome-wide data from 51 Eurasians from ~45,000-7,000 years ago. Over this time, the proportion of Neanderthal DNA decreased from 3-6% to around 2%, consistent with natural selection against Neanderthal variants in modern humans. Whereas there is no evidence of the earliest modern humans in Europe contributing to the genetic composition of present-day Europeans, all individuals between ~37,000 and ~14,000 years ago descended from a single founder population which forms part of the ancestry of present-day Europeans...
June 9, 2016: Nature
Joseph Haddad, Dina Shammaa, Fatmeh Abbas, Rami A R Mahfouz
AIMS: HLA-DPA1 is an important marker in bone marrow and organ transplantation and a highly emerging screening parameter in histocompatibility laboratories. Being highly polymorphic, it has another significant value in detecting population origins and migrations. This is the first study to assess DPA1 allele frequencies in an Arab population. METHODS: The HLA DPA1 alleles were identified using the One-Lambda assays on a Luminex reverse SSO DNA typing system. Our study included 101 individuals coming from different Lebanese geographical areas representing the different communities and religious sects of the country...
June 2016: Meta Gene
Martin B Richards, Pedro Soares, Antonio Torroni
The latest in a series of transformative studies of DNA from prehistoric Europeans focuses on mitochondrial DNA, bringing fresh surprises and filling in important details of the early stages of a European ancestry stretching back more than 40,000 years.
March 21, 2016: Current Biology: CB
Elodie Calvez, Laurent Guillaumot, Laurent Millet, Jérôme Marie, Hervé Bossin, Vineshwaran Rama, Akata Faamoe, Sosiasi Kilama, Magali Teurlai, Françoise Mathieu-Daudé, Myrielle Dupont-Rouzeyrol
BACKGROUND: The Pacific region is an area unique in the world, composed of thousands of islands with differing climates and environments. The spreading and establishment of the mosquito Aedes aegypti in these islands might be linked to human migration. Ae. aegypti is the major vector of arboviruses (dengue, chikungunya and Zika viruses) in the region. The intense circulation of these viruses in the Pacific during the last decade led to an increase of vector control measures by local health authorities...
January 2016: PLoS Neglected Tropical Diseases
Pedro A Soares, Jean A Trejaut, Teresa Rito, Bruno Cavadas, Catherine Hill, Ken Khong Eng, Maru Mormina, Andreia Brandão, Ross M Fraser, Tse-Yi Wang, Jun-Hun Loo, Christopher Snell, Tsang-Ming Ko, António Amorim, Maria Pala, Vincent Macaulay, David Bulbeck, James F Wilson, Leonor Gusmão, Luísa Pereira, Stephen Oppenheimer, Marie Lin, Martin B Richards
There are two very different interpretations of the prehistory of Island Southeast Asia (ISEA), with genetic evidence invoked in support of both. The "out-of-Taiwan" model proposes a major Late Holocene expansion of Neolithic Austronesian speakers from Taiwan. An alternative, proposing that Late Glacial/postglacial sea-level rises triggered largely autochthonous dispersals, accounts for some otherwise enigmatic genetic patterns, but fails to explain the Austronesian language dispersal. Combining mitochondrial DNA (mtDNA), Y-chromosome and genome-wide data, we performed the most comprehensive analysis of the region to date, obtaining highly consistent results across all three systems and allowing us to reconcile the models...
March 2016: Human Genetics
Lucía Rangel-Gamboa, Fernando Martínez-Hernandez, Pablo Maravilla, Roberto Arenas-Guzmán, Ana Flisser
Sporothrix schenckii sensu lato causes subcutaneous mycosis. In this article we analysed its phylogeny and genetic diversity using calmodulin DNA sequences deposited in GenBank database. Population genetics indices were calculated, plus phylogenetic and haplotype network trees were built. Five clades with high values of posterior probability, 47 haplotypes and high diversity in the complex were found. Analysis of partial calmodulin sequences alignment revealed conserved and polymorphic regions that could be used as reference for taxonomic identification...
March 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Candela L Hernández, Pedro Soares, Jean M Dugoujon, Andrea Novelletto, Juan N Rodríguez, Teresa Rito, Marisa Oliveira, Mohammed Melhaoui, Abdellatif Baali, Luisa Pereira, Rosario Calderón
Determining the timing, identity and direction of migrations in the Mediterranean Basin, the role of "migratory routes" in and among regions of Africa, Europe and Asia, and the effects of sex-specific behaviors of population movements have important implications for our understanding of the present human genetic diversity. A crucial component of the Mediterranean world is its westernmost region. Clear features of transcontinental ancient contacts between North African and Iberian populations surrounding the maritime region of Gibraltar Strait have been identified from archeological data...
2015: PloS One
Chunxiang Li, Chao Ning, Erika Hagelberg, Hongjie Li, Yongbin Zhao, Wenying Li, Idelisi Abuduresule, Hong Zhu, Hui Zhou
BACKGROUND: The Tarim Basin in western China, known for its amazingly well-preserved mummies, has been for thousands of years an important crossroad between the eastern and western parts of Eurasia. Despite its key position in communications and migration, and highly diverse peoples, languages and cultures, its prehistory is poorly understood. To shed light on the origin of the populations of the Tarim Basin, we analysed mitochondrial DNA polymorphisms in human skeletal remains excavated from the Xiaohe cemetery, used by the local community between 4000 and 3500 years before present, and possibly representing some of the earliest settlers...
2015: BMC Genetics
GaneshPrasad ArunKumar, Tatiana V Tatarinova, Jeff Duty, Debra Rollo, Adhikarla Syama, Varatharajan Santhakumari Arun, Valampuri John Kavitha, Petr Triska, Bennett Greenspan, R Spencer Wells, Ramasamy Pitchappan
Multiple questions relating to contributions of cultural and demographical factors in the process of human geographical dispersal remain largely unanswered. India, a land of early human settlement and the resulting diversity is a good place to look for some of the answers. In this study, we explored the genetic structure of India using a diverse panel of 78 males genotyped using the GenoChip. Their genome-wide single-nucleotide polymorphism (SNP) diversity was examined in the context of various covariates that influence Indian gene pool...
September 2015: Journal of Human Genetics
Wolfgang Haak, Iosif Lazaridis, Nick Patterson, Nadin Rohland, Swapan Mallick, Bastien Llamas, Guido Brandt, Susanne Nordenfelt, Eadaoin Harney, Kristin Stewardson, Qiaomei Fu, Alissa Mittnik, Eszter Bánffy, Christos Economou, Michael Francken, Susanne Friederich, Rafael Garrido Pena, Fredrik Hallgren, Valery Khartanovich, Aleksandr Khokhlov, Michael Kunst, Pavel Kuznetsov, Harald Meller, Oleg Mochalov, Vayacheslav Moiseyev, Nicole Nicklisch, Sandra L Pichler, Roberto Risch, Manuel A Rojo Guerra, Christina Roth, Anna Szécsényi-Nagy, Joachim Wahl, Matthias Meyer, Johannes Krause, Dorcas Brown, David Anthony, Alan Cooper, Kurt Werner Alt, David Reich
We generated genome-wide data from 69 Europeans who lived between 8,000-3,000 years ago by enriching ancient DNA libraries for a target set of almost 400,000 polymorphisms. Enrichment of these positions decreases the sequencing required for genome-wide ancient DNA analysis by a median of around 250-fold, allowing us to study an order of magnitude more individuals than previous studies and to obtain new insights about the past. We show that the populations of Western and Far Eastern Europe followed opposite trajectories between 8,000-5,000 years ago...
June 11, 2015: Nature
Charmane I Eastman, Christina Suh, Victoria A Tomaka, Stephanie J Crowley
Successful adaptation to modern civilization requires the internal circadian clock to make large phase shifts in response to circumstances (e.g., jet travel and shift work) that were not encountered during most of our evolution. We found that the magnitude and direction of the circadian clock's phase shift after the light/dark and sleep/wake/meal schedule was phase-advanced (made earlier) by 9 hours differed in European-Americans compared to African-Americans. European-Americans had larger phase shifts, but were more likely to phase-delay after the 9-hour advance (to phase shift in the wrong direction)...
2015: Scientific Reports
Stanislav V Dryomov, Azhar M Nazhmidenova, Sophia A Shalaurova, Igor V Morozov, Andrei V Tabarev, Elena B Starikovskaya, Rem I Sukernik
The patterns of prehistoric migrations across the Bering Land Bridge are far from being completely understood: there still exists a significant gap in our knowledge of the population history of former Beringia. Here, through comprehensive survey of mitochondrial DNA genomes retained in 'relic' populations, the Maritime Chukchi, Siberian Eskimos, and Commander Aleuts, we explore genetic contribution of prehistoric Siberians/Asians to northwestern Native Americans. Overall, 201 complete mitochondrial sequences (52 new and 149 published) were selected in the reconstruction of trees encompassing mtDNA lineages that are restricted to Coastal Chukotka and Alaska, the Canadian Arctic, Greenland, and the Aleutian chain...
October 2015: European Journal of Human Genetics: EJHG
Filipa Simão, Heloísa Afonso Costa, Claúdia Vieira da Silva, Teresa Ribeiro, Maria João Porto, Jorge Costa Santos, António Amorim
Portugal has been considered a country of emigrants, nevertheless in the past decades the number of immigrants has grown throughout all the country. This migratory flux has contributed to a raise of heterogeneity at multiple levels. According to statistical data, at the end of 2012 the total number of Angolan immigrants in Portugal equalled about 20,000 individuals. A territorial predominance has been found for the metropolitan region of Lisboa. Angola is a country located in the Atlantic coast of Africa. The presence of Bantu people and the colonisation by Portuguese people on Angolan territory are considered to be the major modulators of the genetic patterns in Angola...
March 2015: Forensic Science International. Genetics
Miroslava Derenko, Boris Malyarchuk, Galina Denisova, Maria Perkova, Andrey Litvinov, Tomasz Grzybowski, Irina Dambueva, Katarzyna Skonieczna, Urszula Rogalla, Iosif Tsybovsky, Ilya Zakharov
BACKGROUND: Although the genetic heritage of aboriginal Siberians is mostly of eastern Asian ancestry, a substantial western Eurasian component is observed in the majority of northern Asian populations. Traces of at least two migrations into southern Siberia, one from eastern Europe and the other from western Asia/the Caucasus have been detected previously in mitochondrial gene pools of modern Siberians. RESULTS: We report here 166 new complete mitochondrial DNA (mtDNA) sequences that allow us to expand and re-analyze the available data sets of western Eurasian lineages found in northern Asian populations, define the phylogenetic status of Siberian-specific subclades and search for links between mtDNA haplotypes/subclades and events of human migrations...
2014: BMC Evolutionary Biology
Lindsay V Clark, Joe E Brummer, Katarzyna Głowacka, Megan C Hall, Kweon Heo, Junhua Peng, Toshihiko Yamada, Ji Hye Yoo, Chang Yeon Yu, Hua Zhao, Stephen P Long, Erik J Sacks
BACKGROUND AND AIMS: Miscanthus is a perennial C4 grass that is a leading potential feedstock crop for the emerging bioenergy industry in North America, Europe and China. However, only a single, sterile genotype of M. × giganteus (M×g), a nothospecies derived from diploid M. sinensis (Msi) and tetraploid M. sacchariflorus (Msa), is currently available to farmers for biomass production. To facilitate breeding of Miscanthus, this study characterized genetic diversity and population structure of Msi in its native range of East Asia...
July 2014: Annals of Botany
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