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Medicines Management

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https://www.readbyqxmd.com/read/28945018/-expert-consensus-on-the-design-and-implementation-of-clinical-safety-centralized-monitoring-study-of-chinese-medical-injection
#1
Jun-Hua Zhang, Jing-Tian Ren, Jing-Qing Hu, Yan-Ming Xie, Hai-Bo Song, Ming-Jun Zhu, Rui Gao, Zhong Wang, Wen-Ke Zheng, Xue-Lin Li, Meng Jiang, Yu-Hong Huang, Fang Lu, Li-Yun He, Wei-Xiong Lian, Zhong-Qi Yang, Wei-An Yuan, Si-Yuan Hu, Bao-He Wang, Wei-Liang Wang, De-Quan Ren, Bo-Li Zhang
Along with the increase of clinical application, the safety of traditional Chinese medicine gained more and more attentions. In particular, the safety evaluation of Chinese medical injections has become a mandatory task should be completed by pharmaceutical companies under the supervision of China Food and Drug Administration(CFDA). Due to the weak foundation of previous studies, the safety issues of Chinese medical injections have not been fully understood, and lack of scientific and rational risk management programs...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945017/-a-strategy-of-constructing-the-technological-system-for-quality-control-of-chinese-medicine-based-on-process-control-and-management
#2
Yi-Yu Cheng, Zhong-Zhi Qian, Bo-Li Zhang
The current situation, bottleneck problems and severe challenges in quality control technology of Chinese Medicine (CM) are briefly described. It is presented to change the phenomenon related to the post-test as the main means and contempt for process control in drug regulation, reverse the situation of neglecting the development of process control and management technology for pharmaceutical manufacture and reconstruct the technological system for quality control of CM products. The regulation and technology system based on process control and management for controlling CM quality should be established to solve weighty realistic problems of CM industry from the root causes, including backwardness of quality control technology, weakness of quality risk control measures, poor reputation of product quality and so on...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944731/the-fda-unapproved-drugs-initiative-an-observational-study-of-the-consequences-for-drug-prices-and-shortages-in-the-united-states
#3
Ravi Gupta, Sanket S Dhruva, Erin R Fox, Joseph S Ross
BACKGROUND: Hundreds of drug products are currently marketed in the United States without approval from the FDA. The 2006 Unapproved Drugs Initiative (UDI) requires manufacturers to remove these drug products from the market or obtain FDA approval by demonstrating evidence of safety and efficacy. Once the FDA acts against an unapproved drug, fewer manufacturers remain in the market, potentially enabling drug price increases and greater susceptibility to drug shortages. There is a need for systematic study of the UDI's effect on prices and shortages of all targeted drugs...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944582/myopenia-and-precision-p4-medicine
#4
EDITORIAL
John E Morley, Stefan D Anker
Precision (P4) medicine represents a new medical paradigm that focuses on Personalized, Predictive, Preventive and Participatory approaches. The P4 paradigm is particularly appropriate for moving the care of persons with myopenia forward. Muscular dystrophies are clearly a set of genetically different diseases where genomics are the basis of diagnosis, and genetic modulation via DNA, oligonucleotides and clustered regularly interspaced short palendronic repeats hold great potential for a cure. The utility of personalized genomics for sarcopenia coupled with utilizing a predictive approach for the diagnosis with early preventive strategies is a key to improving sarcopenic outcomes...
September 24, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28944537/pharmacologic-management-of-voice-disorders-by-general-medicine-providers-and-otolaryngologists
#5
Seth M Cohen, Hui-Jie Lee, Nelson Roy, Stephanie Misono
OBJECTIVES: 1) To compare laryngeal diagnoses from general medical providers (GMP) to otolaryngologists following GMP-based medication trial, and 2) to evaluate associations between GMP medication trials and pharmacologic treatment by otolaryngologists. METHODS: Retrospective cohort analysis using large, national administrative U.S. claims database. Patients with laryngeal/voice disorders as per the International Classification of Diseases, Ninth Revision, Clinical Modification codes from January 1, 2010, to December 31, 2012, seen by a GMP and then an otolaryngologist between 2 weeks to 3 months after the GMP visit, were included...
September 25, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28944281/adenovirus-mediated-gene-delivery-potential-applications-for-gene-and-cell-based-therapies-in-the-new-era-of-personalized-medicine
#6
Cody S Lee, Elliot S Bishop, Ruyi Zhang, Xinyi Yu, Evan M Farina, Shujuan Yan, Chen Zhao, Zongyue Zheng, Yi Shu, Xingye Wu, Jiayan Lei, Yasha Li, Wenwen Zhang, Chao Yang, Ke Wu, Ying Wu, Sherwin Ho, Aravind Athiviraham, Michael J Lee, Jennifer Moriatis Wolf, Russell R Reid, Tong-Chuan He
With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology, it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies. Despite numerous setbacks, efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases. It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies...
June 2017: Genes & Diseases
https://www.readbyqxmd.com/read/28944053/implementation-of-who-multimodal-strategy-for-improvement-of-hand-hygiene-a-quasi-experimental-study-in-a-traditional-chinese-medicine-hospital-in-xi-an-china
#7
Li Shen, Xiaoqing Wang, Junming An, Jialu An, Ning Zhou, Lu Sun, Hong Chen, Lin Feng, Jing Han, Xiaorong Liu
BACKGROUND: Hand hygiene (HH) is an essential component for preventing and controlling of healthcare-associated infection (HAI), whereas compliance with HH among health care workers (HCWs) is frequently poor. This study aimed to assess compliance and correctness with HH before and after the implementation of a multimodal HH improvement strategy launched by the World Health Organization (WHO). METHODS: A quasi-experimental study design including questionnaire survey generalizing possible factors affecting HH behaviors of HCWs and direct observation method was used to evaluate the effectiveness of WHO multimodal HH strategy in a hospital of Traditional Chinese Medicine...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28943979/a-qualitative-study-on-pharmacists-perception-on-integrating-pharmacists-into-private-general-practitioner-s-clinics-in-malaysia
#8
Pui S Saw, Lisa Nissen, Christopher Freeman, Pei S Wong, Vivienne Mak
BACKGROUND: Private general practitioners in Malaysia largely operates as solo practices - prescribing and supplying medications to patients directly from their clinics, thus posing risk of medication-related problems to consumers. A pharmacy practice reform that integrates pharmacists into primary healthcare clinics can be a potential initiative to promote quality use of medication. This model of care is a novel approach in Malaysia and research in the local context is required, especially from the perspectives of pharmacists...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28943040/treatment-of-musculo-skeletal-pain-in-haemophilia
#9
REVIEW
E Carlos Rodriguez-Merchan
Musculo-skeletal pain treatment is inadequate in many haemophilic patients. Analgesics are used only by 36% of adult patients. FVIII/FIX intravenous infusion is mainly used to lessen pain, followed in frequency by usage of NSAIDS (primarily COX-2 inhibitors). In about 30% of patients, pain continues after infusion of F VIII/IX. In acute haemarthroses pain treatment must continue until total disappearance (checked by ultrasonography) and include haematologic treatment, short-term rest of the involved joint, cryotherapy, joint aspiration and analgesic medication (paracetamol in mild pain, metamizole for more intense pain, and in a few precise patients, soft opioids such as codeine or tramadol)...
September 19, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28942904/a-brief-historical-perspective-of-cancer-rehabilitation-and-contributions-from-the-national-institutes-of-health
#10
REVIEW
Lynn H Gerber, Bonnie Hodsdon, Leora Ellen Comis, Leighton Chan, John I Gallin, Charles L McGarvey
People who have cancer diagnoses often need care throughout their lives through all stages of their illness. These stages include diagnosis, primary treatment, survivorship, and end of life. The management of people with cancer, now a common and chronic illness with long-term survival improving, is complex, challenging, and rapidly changing. Rehabilitation for people with cancer diagnoses is a new specialty and is charged with providing care throughout the trajectory of illness and wellness to maximize potential for function and mitigate disability...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28942886/who-treats-lung-cancer-results-from-a-global-survey
#11
Takefumi Komiya, Christine B Mackay, Prabhakar Chalise
BACKGROUND: In most Western nations, the medical oncologist plays a significant role in the administration of systemic therapy for lung cancer. In Japan however, treatment for lung cancer has historically been provided by pulmonologists and thoracic surgeons. A comparison of the management of advanced disease between Japan and other nations has not been described. METHODS: An online, self-administered, international survey was sent to 3907 active members of the American Society of Clinical Oncology...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28942776/clinician-perspectives-on-the-management-of-abnormal-subcritical-tests-in-an-urban-academic-safety-net-health-care-system
#12
Cassidy Clarity, Urmimala Sarkar, Jonathan Lee, Margaret A Handley, L Elizabeth Goldman
BACKGROUND: Missed or delayed follow-up of abnormal subcritical tests (tests that do not require immediate medical attention) can lead to poor patient outcomes. Safety-net health systems with limited resources and socially complex patients are vulnerable to safety gaps resulting from delayed management. Clinician perspectives to identify system challenges, vulnerable situations, and potential solutions were sought in focus groups. METHODS: Five semistructured focus groups were conducted in 2015 with purposefully sampled clinicians from radiology, hospital medicine, emergency medicine, risk management, and ambulatory care from an urban, academic, integrated, safety-net health system...
October 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28942724/current-models-of-support-from-community-pharmacies-for-patients-on-oral-anticancer-medicines
#13
Melanie Dalby
Administration of chemotherapy is moving into the community as more and more therapies to treat cancer are being developed as oral medications. Patients taking these oral medications still require support, as many of these agents can be toxic. This support could be simple side effect management, compliance issues or even reassurance with regards to their diagnosis as examples. Community pharmacies are ideally placed within the community to help these patients. The purpose of this review is to determine what support community pharmacies are currently providing for patients taking oral anticancer medication and if there is a model that can be adopted or adapted to be used elsewhere...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28942692/the-role-of-tele-medicine-in-patients-with-respiratory-diseases
#14
Nicolino Ambrosino, Claudio Fracchia
Tele-medicine is a clinical application connecting a patient with specialized care consultants by means of electronic platforms, potentially able to improve patients' self-management and allow for the care of patients with limited access to health services. This article summarizes the use of tele-medicine as a tool in managing patients suffering from some pathological respiratory conditions. Areas covered: We searched papers published between 1990 and 2017 dealing with tele-medicine and respiratory diseases, COPD, asthma, interstitial lung disease, chronic respiratory failure, neuromuscular diseases, critical illness, home mechanical ventilation, and also legal and economic issues...
September 25, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28942388/restorative-valve-therapy-by-endogenous-tissue-restoration-tomorrow-s-world-reflection-on-the-europcr-2017-session-on-endogenous-tissue-restoration
#15
Patrick W Serruys, Yosuke Miyazaki, Athanasios Katsikis, Mohammad Abdelghani, Martin B Leon, Renu Virmani, Thierry Carrel, Martijn Cox, Yoshinobu Onuma, Osama I I Soliman
The current standard of treatment of valvular diseases with severe functional and/or clinical consequences is the repair or replacement of the valve, which is usually surgical or, in specific scenarios, percutaneous. The available prosthetic valves, however, are not a magic bullet in the physicians' arsenal for the management of valvular diseases, since the age-dependent structural valve deterioration (SVD) and the need for prolonged systemic anticoagulation in the case of metallic prosthetic valves are not inconsequential during the lifespan of a patient with an implanted prosthetic valve...
September 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28942139/computer-technologies-to-integrate-medical-treatments-to-manage-multimorbidity
#16
REVIEW
David Riaño, Wilfrido Ortega
The high prevalence of multimorbid cases is a challenge for Health-Care Systems today. Clinical practice guidelines are the means to register and transmit the available evidence-based medical knowledge concerning concrete diseases. Several computer languages have been defined to represent this knowledge in a way that computers could use to help physicians in the daily practice of medicine. The generation of guidelines for all possible multimorbidities entails several issues that are difficult to address. Consequently, numerous medical informatics technologies have appeared merging computer information structures in a way that the treatment knowledge about single diseases could be combined in order to deliver health-care to patients suffering from multimorbidity...
September 20, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28941850/meso-level-multi-disciplinary-approach-for-reduction-of-pre-treatment-loss-to-follow-up-in-revised-national-tuberculosis-control-program-delhi-india
#17
Nandini Sharma, Shivani Chandra, Meera Dhuria, Charu Kohli, Kamal Kishore Chopra, Nishi Aggarwal, Kuldeep Sachdeva
BACKGROUND: Universal access to tuberculosis (TB) care services emphasizes early detection and initiation of treatment for all pulmonary TB patients. Pre-treatment loss to follow-up patients needs to be actively tracked and treated to break the chain of transmission in the community. OBJECTIVES: MATERIALS AND METHODS: A questionnaire based cross sectional study of a sample of 340 patients who were pre-treatment loss to follow-up was conducted from November 2011 to March 2012 in Delhi...
October 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28941816/risk-factors-associated-with-milk-fever-occurrence-in-grazing-dairy-cattle
#18
A Saborío-Montero, B Vargas-Leitón, J J Romero-Zúñiga, J M Sánchez
The aim of this study was to determine risk factors associated with milk fever (MF) occurrence in Costa Rican grazing dairy cattle. A total of 69,870 cows from 126 dairy herds were included in the study. Data were collected in the Veterinary Automated Management and Production Control Program software by the Population Medicine Research Program of the Veterinary Medicine School, National University of Costa Rica, from 1985 to 2014. To determine the risk factors for MF, 2 logistic regression mixed models were evaluated...
September 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28941749/efficacy-of-a-transition-clinic-on-hospital-readmissions
#19
Vidya Chakravarthy, Mary J Ryan, Amir Jaffer, Robyn Golden, Regina McClenton, Jisu Kim, Irwin Press, Tricia Johnson
BACKGROUND: A primary care staffed transition clinic is one potential strategy for reducing thirty-day readmissions for patients without an established primary care physician, but the effectiveness has not been studied. The objective was to test whether patients who completed a post-discharge transition clinic appointment were less likely to be readmitted within thirty days. METHODS: This retrospective cross-sectional study included adults with Medicare and Medicaid coverage who were discharged from general medicine units at Rush University Medical Center between October 2013 and October 2014...
September 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28941606/new-developments-in-hypertrophic-cardiomyopathy
#20
REVIEW
Robert M Cooper, Claire E Raphael, Max Liebregts, Nandan S Anavekar, Josef Veselka
Hypertrophic cardiomyopathy is the leading cause of sudden death in young individuals and an important cause of heart failure at any age. In this review we discuss advances in investigation and management of this heterogenous disease. Improved cardiac imaging has allowed us to detail many of the structural abnormalities whereas the use of new techniques, predominantly in cardiac magnetic resonance imaging, has given us a greater insight in to tissue architecture, mechanism of contractile abnormalities, and function...
October 2017: Canadian Journal of Cardiology
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