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https://www.readbyqxmd.com/read/28231686/evaluation-of-the-amoxicillin-concentrations-in-amniotic-fluid-placenta-umbilical-cord-blood-and-maternal-serum-two-hours-after-intravenous-administration
#1
(no author information available yet)
OBJECTIVES: The aims of this study were to evaluate amoxicillin concentrations in amniotic fluid, placenta, umbilical cord blood and maternal blood two hours after intravenous administration to assess obstetric and non-obstetric factors that could have influences on the penetration of the antibiotic into the examined tissues and to analyze the sensitivity to amoxicillin of the most common pathogens isolated from the genital tract. METHODS: A total of 35 full-term pregnant women who qualified for elective Caesarean delivery were included in the study...
October 24, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28231436/myocardial-homing-of-mesenchymal-stem-cells-following-intrapericardial-application-and-amplification-by-inflammation-an-experimental-pilot-study
#2
Nina Jung, Heinz Rupp, Rembert Koczulla, Claus Vogelmeier, Peter Alter
Recent studies demonstrated potential effects of stem cells on cardiac function in heart failure. However, influences of the technique of application remained undetermined. In the present study, the pericardial sac was used as depot for fluorescent-labeled mesenchymal stem cells in rats. To evaluate influences of inflammation on cell homing, a sterile pericarditis was induced by talc. It is shown that intrapericardial stem cells application is sufficient to provide myocardial penetration. The extent of homing was amplified by inflammation in a talc-induced pericarditis...
February 23, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28231390/intraoperative-assessment-of-laryngeal-pathologies-with-optical-coherence-tomography-integrated-into-a-surgical-microscope
#3
Anna S Englhard, Tom Betz, Veronika Volgger, Eva Lankenau, Georg J Ledderose, Herbert Stepp, Christian Homann, Christian S Betz
OBJECTIVE: Endoscopic examination followed by tissue biopsy is the gold standard in the evaluation of lesions of the upper aerodigestive tract. However, it can be difficult to distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical coherence tomography (OCT) is a non-invasive technique which acquires high-resolution, cross-sectional images of tissue in vivo. Integrated into a surgical microscope, it allows the intraoperative evaluation of lesions simultaneously with microscopic visualization...
February 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28231036/aqueous-humor-penetration-and-biological-activity-of-moxifloxacin-0-5-ophthalmic-solution-alone-or-with-dexamethasone-0-1
#4
Rachel L R Gomes, Rodrigo Galvão Viana, Luiz Alberto S Melo, Alessandro Carvalho Cruz, Eunice Mayumi Suenaga, Kenneth R Kenyon, Mauro Campos
PURPOSE: To compare aqueous humor concentrations of topically applied moxifloxacin 0.5% ophthalmic solution alone or in combination with dexamethasone 0.1% and to correlate these concentrations with the minimum inhibitory concentrations (MICs) for common endophthalmitis-causing organisms. METHODS: Sixty-eight patients undergoing routine phacoemulsification with intraocular lens implantation received either moxifloxacin 0.5% alone or moxifloxacin 0.5% combined with dexamethasone...
March 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28230904/effects-of-re-heating-tissue-samples-to-core-body-temperature-on-high-velocity-ballistic-projectile-tissue-interactions
#5
Caitlin Humphrey, Maciej Henneberg, Christian Wachsberger, Nicholas Maiden, Jaliya Kumaratilake
Damage produced by high-speed projectiles on organic tissue will depend on the physical properties of the tissues. Conditioning organic tissue samples to human core body temperature (37°C) prior to conducting ballistic experiments enables their behavior to closely mimic that of living tissues. To minimize autolytic changes after death, the tissues are refrigerated soon after their removal from the body and re-heated to 37°C prior to testing. This research investigates whether heating 50-mm-cube samples of porcine liver, kidney, and heart to 37°C for varying durations (maximum 7 h) can affect the penetration response of a high-speed, steel sphere projectile...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230878/multifunctional-hybrid-porous-filters-with-hierarchical-structures-for-simultaneous-removal-of-indoor-vocs-dusts-and-microorganisms
#6
Yang Zhao, Ze-Xian Low, Shasha Feng, Zhaoxiang Zhong, Yong Wang, Zhong Yao
Air purification often requires multiple layers of filters with different functions to remove various air pollutants, which lead to high pressure drop, high air flow path and frequent filter replacement. In this work, a novel multifunctional Ag@MWCNTs/Al2O3 hybrid filter with a depth-type hierarchical structure for simultaneous removal of fine particles, microorganisms and VOCs was designed and fabricated. The novel hybrid air filter showed leading air purification performances to date, achieving 82.24% degradation of formaldehyde at room temperature, 99...
February 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28230860/carma2sh-and-ulk2-control-pathogen-associated-molecular-patterns-recognition-in-human-keratinocytes-psoriasis-linked-carma2sh-mutants-escape-ulk2-censorship
#7
Ivan Scudiero, Pellegrino Mazzone, Luca E D'Andrea, Angela Ferravante, Tiziana Zotti, Gianluca Telesio, Gabriele De Rubis, Carla Reale, Maddalena Pizzulo, Shanmugakonar Muralitharan, Pasquale Vito, Romania Stilo
The molecular complexes formed by specific members of the family of CARMA proteins, the CARD domain-containing adapter molecule BCL10 and MALT1 (CBM complex) represent a central hub in regulating activation of the pleiotropic transcription factor NF-κB. Recently, missense mutations in CARMA2sh have been shown to cause psoriasis in a dominant manner and with high penetrancy. Here, we demonstrate that in human keratinocytes CARMA2sh plays an essential role in the signal transduction pathway that connects pathogen-associated molecular patterns recognition to NF-κB activation...
February 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28230812/urban-pollutant-transport-and-infiltration-into-buildings-using-perfluorocarbon-tracers
#8
James C Matthews, Asan Bacak, M Anwar H Khan, Matthew D Wright, Michael Priestley, Damien Martin, Carl J Percival, Dudley E Shallcross
People spend the majority of their time indoors and therefore the quality of indoor air is worthy of investigation; indoor air quality is affected by indoor sources of pollutants and from pollutants entering buildings from outdoors. In this study, unique perfluorocarbon tracers were released in five experiments at a 100 m and ~2 km distance from a large university building in Manchester, UK and tracer was also released inside the building to measure the amount of outdoor material penetrating into buildings and the flow of material within the building itself...
February 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28230629/point-of-injury-tourniquet-application-during-operation-protective-edge-what-de-we-learn
#9
Amir Shlaifer, Avraham Yitzhak, Erez N Baruch, Avi Shina, Alexandra Satanovsky, Amiram Shovali, Ofer Almog, Elon Glassberg
BACKGROUND: Hemorrhage is a leading cause of preventable death on the battlefield. Timely tourniquet application to massively bleeding extremity wounds is critical for casualty survival albeit with reported adverse effects to extremity integrity. The aim of this study was to describe the immediate and short term outcomes of point of injury (POI) tourniquet applications during 'Operation Protective Edge' (OPE). METHODS: A case series study regarding tourniquet application at the POI during OPE was collected...
February 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28230627/surgical-outcomes-after-trauma-pneumonectomy-revisited
#10
Kazuhide Matsushima, Alberto Aiolfi, Caroline Park, David Rosen, Aaron Strumwasser, Elizabeth Benjamin, Kenji Inaba, Demetrios Demetriades
INTRODUCTION: Trauma pneumonectomy has been historically associated with an exceedingly high morbidity and mortality. The recent advent of standardized reporting and data-collecting measures has facilitated large volume data-analysis on predictors and outcomes of trauma pneumonectomy. The purpose of this study is to describe patient characteristics and outcomes of the patients who underwent trauma pneumonectomy in the modern era and identify clinical factors associated with postoperative mortality...
February 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28230151/potential-microbial-contamination-during-sampling-of-permafrost-soil-assessed-by-tracers
#11
Toke Bang-Andreasen, Morten Schostag, Anders Priemé, Bo Elberling, Carsten S Jacobsen
Drilling and handling of permanently frozen soil cores without microbial contamination is of concern because contamination e.g. from the active layer above may lead to incorrect interpretation of results in experiments investigating potential and actual microbial activity in these low microbial biomass environments. Here, we present an example of how microbial contamination from active layer soil affected analysis of the potentially active microbial community in permafrost soil. We also present the development and use of two tracers: (1) fluorescent plastic microspheres and (2) Pseudomonas putida genetically tagged with Green Fluorescent Protein production to mimic potential microbial contamination of two permafrost cores...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229513/pathogenic-asxl1-somatic-variants-in-reference-databases-complicate-germline-variant-interpretation-for-bohring-opitz-syndrome
#12
Colleen M Carlston, Anne H O'Donnell-Luria, Hunter R Underhill, Beryl B Cummings, Ben Weisburd, Eric V Minikel, Daniel P Birnbaum, Tatiana Tvrdik, Daniel G MacArthur, Rong Mao
The clinical interpretation of genetic variants has come to rely heavily on reference population databases such as the Exome Aggregation Consortium (ExAC) database. Pathogenic variants in genes associated with severe, pediatric-onset, highly penetrant, autosomal dominant conditions are assumed to be absent or rare in these databases. Exome sequencing of a six-year-old female patient with seizures, developmental delay, dysmorphic features and failure to thrive identified an ASXL1 variant previously reported as causative of Bohring-Opitz syndrome (BOS)...
February 23, 2017: Human Mutation
https://www.readbyqxmd.com/read/28229454/analysis-of-a-fully-penetrant-spinocerebellar-ataxia-type-8-brazilian-family
#13
V P Cintra, C M Lourenço, M M V Rocha, P J Tomaselli, W Marques
Spinocerebellar ataxia type 8 (SCA8) is a progressive neurological disorder caused by the expanded repeat CTA/CTG of two overlapping genes, ATXN8OS and ATXN8, expressed bidirectionally. Normal alleles have 15-50 repeats, and pathogenic alleles range from 71 to 1300 repeats. The disorder is relatively rare, accounting for about 2%-5% of the autosomal dominant forms of hereditary ataxia worldwide. However, the prevalence of disease-causing ATXN8OS/ATXN8 expansions is higher than the disease because of the reduced penetrance of the expanded allele...
February 22, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28228885/omental-flap-transposition-for-inferior-vena-cava-filter-penetration
#14
Junji Yamaguchi, Takamichi Miyamoto, Nobuhiro Hara, Tetsuo Yamaguchi, Tomoyuki Umemoto
A 40-year-old woman presented with uterine malignancy, deep vein thrombosis, and nonmassive pulmonary embolism in both lungs. Gunter-tulip filter was inserted, because she had severe genital bleeding, which is one of the contraindications to anticoagulation therapy. Total hysterectomy was conducted and anticoagulation therapy was started afterward. The thrombus worsened perioperatively, and the filter could not be retrieved. Since there was lymph node recurrence, the second time operation was performed. During operation, the struts were found to be penetrating the inferior vena cava...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228822/the-feasibility-of-implementation-of-ultrasound-equipment-standards-set-by-united-kingdom-professional-bodies
#15
Nicholas J Dudley, Debbie Harries, Jessica Wardle
INTRODUCTION: The Royal College of Radiologists and the Society and College of Radiographers in the United Kingdom published 'Standards for the provision of an ultrasound service', including application-specific limiting values for resolution and penetration. No measurement methods were detailed. We aimed to explore a possible theoretical basis for the standards and to develop a measurement protocol. METHODS: Since application-specific standards fail to account for probes of different frequencies used for similar applications and no evidence for the standards was provided, we developed generic standards based on theoretical considerations...
February 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/28228473/violence-related-ambulance-call-outs-in-the-north-west-of-england-a-cross-sectional-analysis-of-nature-extent-and-relationships-to-temporal-celebratory-and-sporting-events
#16
Zara Quigg, Ciara McGee, Karen Hughes, Simon Russell, Mark A Bellis
OBJECTIVE: The aim of this study was to explore the potential of ambulance call-out data in understanding violence to inform about prevention activity. METHOD: This cross-sectional (2013-2015) study examined the nature, extent and characteristics of violence-related ambulance call-outs (n=15 687) across North West England and relationships with temporal, celebratory and sporting events. RESULTS: The majority of call-outs were for men, with a mean age of 33 years...
February 21, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28228391/penetrating-mitral-annular-abscess-ruptured-into-the-left-atrium-a-rare-cause-of-mitral-regurgitation
#17
Gopal Chandra Ghosh, Amal Paul, Anoop George Alex, Paul V George
No abstract text is available yet for this article.
February 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28228196/the-hidden-story-of-innovation-charity-hospital-angola-prison-and-the-challenging-of-surgical-dogma
#18
Patrick Greiffenstein, Paul R Hastings
The late 1960s was a period of significant upheaval of social, cultural, and scientific norms. The generally accepted notion of mandatory laparotomy for all penetrating abdominal injuries was among those norms being called into question across the country and many advocated expectant management of selected patients presenting with this type of injury. Leaders of the surgical community published opinions on either side of the argument. The house staff at Charity Hospital during this period was among the busiest in the nation in treating these injuries, many of them inmates of the Louisiana State Penitentiary who used self-inflicted stab wounds to the abdomen as a means of temporary respite from the inhumane conditions in the prison...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28228173/optimization-of-vascular-casting-for-three-dimensional-fluorescence-cryo-imaging-of-collateral-vessels-in-the-ischemic-rat-hindlimb
#19
Janina C V Schwarz, Monique G J T B van Lier, Erik N T P Bakker, Judith de Vos, Jos A E Spaan, Ed VanBavel, Maria Siebes
Development of collateral vessels, arteriogenesis, may protect against tissue ischemia, however, quantitative data on this process remain scarce. We have developed a technique for replicating the entire arterial network of ischemic rat hindlimbs in three dimensions (3D) based on vascular casting and automated sequential cryo-imaging. Various dilutions of Batson's No. 17 with methyl methacrylate were evaluated in healthy rats, with further protocol optimization in ischemic rats. Penetration of the resin into the vascular network greatly depended on dilution; the total length of casted vessels below 75 µm was 13-fold higher at 50% dilution compared with the 10% dilution...
February 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28228081/the-neurobiology-and-psychiatric-perspective-of-vaginismus-linking-the-pharmacological-and-psycho-social-interventions
#20
Zuri Shahidii Kadir, Hatta Sidi, Jaya Kumar, Srijit Das, Marhani Midin, Najwa Baharuddin
Vaginismus is an involuntary muscle contraction of the outer third of vaginal barrel causing sexual penetration almost impossible. It is generally classified under sexual pain disorder (SPD). In Diagnostic and Statistical Manual, 5th edition, it is classified under the new rubric of Genito-Pelvic Pain/Sexual Penetration Disorder. This fear-avoidance condition poses an ongoing significant challenge to the medical and health professionals due to the very demanding needs in health care despite its unpredictable prognosis...
February 22, 2017: Current Drug Targets
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