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https://www.readbyqxmd.com/read/29677136/cytoplasmic-translocation-of-nucleolar-protein-nop53-promotes-viral-replication-by-suppressing-host-defense
#1
Wen Meng, Shi-Chong Han, Cui-Cui Li, Hui-Jun Dong, Jian-Yu Chang, Hwa-Chain Robert Wang, Xiao-Jia Wang
NOP53 is a tumor suppressor protein located in the nucleolus and is translocated to the cytoplasm during infection by vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1), as shown in our previous study. Cytoplasmic NOP53 interacts with the retinoic acid-inducible gene I (RIG-I) to remove its K63-linked ubiquitination, leading to attenuation of type I interferon IFN-β. In the present study, we found no obvious translocation of NOP53 in infection by a mutant virus lacking ICP4 (HSV-1/d120, replication inadequate)...
April 20, 2018: Viruses
https://www.readbyqxmd.com/read/29677082/artificial-intelligence-can-predict-daily-trauma-volume-and-average-acuity
#2
David P Stonko, Bradley M Dennis, Richard D Betzold, Allan B Peetz, Oliver L Gunter, Oscar D Guillamondegui
INTRODUCTION: The goal of this study was to integrate temporal and weather data in order to create an artificial neural network (ANN) to predict trauma volume, the number of emergent operative cases, and average daily acuity at a level 1 trauma center. METHODS: Trauma admission data from TRACS and weather data from the National Oceanic and Atmospheric Administration (NOAA) was collected for all adult trauma patients from July 2013-June 2016. The ANN was constructed using temporal (time, day of week), and weather factors (daily high, active precipitation) to predict four points of daily trauma activity: number of traumas, number of penetrating traumas, average ISS, and number of immediate OR cases per day...
April 19, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29676980/effect-of-bleaching-gel-viscosity-on-tooth-whitening-efficacy-and-pulp-chamber-penetration-an-in-vitro-study
#3
S R Kwon, Fnu Pallavi, Y Shi, U Oyoyo, A Mohraz, Y Li
OBJECTIVES: Whitening efficacy has been related to hydrogen peroxide (HP) diffusion into tooth structure. However, little information is available relating rheological properties to whitening efficacy. The purpose was to evaluate the whitening efficacy and HP penetration level of a 10% HP gel at three different viscosities and to compare them to a strip delivery system. METHODS AND MATERIALS: Extracted molars (n=120) were randomly assigned into five groups (n=24/ group): NC_MED (negative control; median): medium viscosity gel without HP; LOW: 10% HP gel (low viscosity experimental gel, Ultradent Products Inc); MED: 10% HP gel (medium viscosity experimental gel, Ultradent); HIGH: 10% HP gel (high viscosity gel, Ultradent); and CWS: Crest 3D Whitestrips 1-Hour Express (Procter & Gamble)...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29676908/fluorine-grafted-cu7s4-au-heterodimers-for-multimodal-imaging-guided-photothermal-therapy-with-high-penetration-depth
#4
Jiabin Cui, Rui Jiang, Chang Guo, Xilin Bai, Suying Xu, Leyu Wang
We report the multifunctional nanocomposites (NCs) consisting of 19F-moieties grafted Cu7S4-Au nanoparticles (NPs) through click chemistry for sensitive and negligible background 19F-magnetic resonance imaging (19F-MRI) and computed tomography (CT) imaging guided photothermal therapy. The localized surface plasmon resonance (LSPR) peak can be reasonably tuned to the in vivo transparent window (800-900 nm) by coupling Au NPs (<10 nm, LSPR 530 nm) with Cu7S4 NPs (<15 nm, LSPR 1500 nm) into the Cu7S4-Au heterodimers...
April 20, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29676570/caznos-nd-3-emits-tissue-penetrating-near-infrared-light-upon-force-loading
#5
Lejing Li, Lothar Wondraczek, Lihua Li, Yu Zhang, Ye Zhu, Mingying Peng, Chuanbin Mao
Mechanoluminescent (ML) materials are mechano-optical converters that can emit light under an external mechanical stimulus. All the existing ML materials can only emit light from near ultraviolet to red, which is outside the near-infrared (NIR) windows desired for biomechanical imaging. No studies have been done on doping rare earth (RE) ions with photoluminescence (PL) in the NIR region into a compound to form a ML material that emits NIR light in response to an external force. Here, we show that doping RE ions with a NIR PL into an inorganic compound does not usually result in the formation of a NIR ML material, which can only be achieved in the combination of Nd3+ ions and a CaZnOS compound among the combinations we studied...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29676568/toward-rechargeable-persistent-luminescence-for-the-first-and-third-biological-windows-via-persistent-energy-transfer-and-electron-trap-redistribution
#6
Jian Xu, Daisuke Murata, Jumpei Ueda, Bruno Viana, Setsuhisa Tanabe
Persistent luminescence (PersL) imaging without real-time external excitation has been regarded as the next generation of autofluorescence-free optical imaging technology. However, to achieve improved imaging resolution and deep tissue penetration, developing new near-infrared (NIR) persistent phosphors with intense and long duration PersL over 1000 nm is still a challenging but urgent task in this field. Herein, making use of the persistent energy transfer process from Cr3+ to Er3+ , we report a novel garnet persistent phosphor of Y3 Al2 Ga3 O12 codoped with Er3+ and Cr3+ (YAG G:Er-Cr), which shows intense Cr3+ PersL (∼690 nm) in the deep red region matching well with the first biological window (NIR-I, 650-950 nm) and Er3+ PersL (∼1532 nm) in the NIR region matching well with the third biological window (NIR-III, 1500-1800 nm)...
April 20, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29676523/characterization-of-low-abundance-species-in-the-active-pharmaceutical-ingredient-of-cigb-300-a-clinical-grade-anticancer-synthetic-peptide
#7
Hilda Garay, Luis Ariel Espinosa, Yasser Perera, Aniel Sánchez, David Diago, Silvio E Perea, Vladimir Besada, Osvaldo Reyes, Luis Javier González
CIGB-300 is a first-in-class synthetic peptide-based drug of 25 amino acids currently undergoing clinical trials in cancer patients. It contains an amidated disulfide cyclic undecapeptide fused to the TAT cell-penetrating peptide through a beta-alanine spacer. CIGB-300 inhibits the CK2-mediated phosphorylation leading to apoptosis of tumor cells in vitro, and in vivo in cancer patients. Despite the clinical development of CIGB-300, the characterization of peptide-related impurities present in the active pharmaceutical ingredient has not been reported earlier...
April 20, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29676440/an-effective-modestly-intensive-re-induction-regimen-with-bortezomib-in-relapsed-or-refractory-paediatric-acute-lymphoblastic-leukaemia
#8
Gertjan J L Kaspers, Denise Niewerth, Bram A J Wilhelm, Peggy Scholte-van Houtem, Marta Lopez-Yurda, Johannes Berkhof, Jacqueline Cloos, Valerie de Haas, Ron A Mathôt, Andishe Attarbaschi, André Baruchel, Eveline S de Bont, Franca Fagioli, Claudia Rössig, Thomas Klingebiel, Barbara De Moerloose, Brigitte Nelken, Giuseppe Palumbo, Dirk Reinhardt, Pierre-Simon Rohrlich, Pauline Simon, Arend von Stackelberg, Michel M Zwaan
This trial explored the efficacy of re-induction chemotherapy including bortezomib in paediatric relapsed/refractory acute lymphoblastic leukaemia. Patients were randomized 1:1 to bortezomib (1.3 mg/m2 /dose) administered early or late to a dexamethasone and vincristine backbone. Both groups did not differ regarding peripheral blast count on day 8, the primary endpoint. After cycle 1, 8 of 25 (32%) patients achieved complete remission with incomplete blood count recovery, 7 (28%) a partial remission and 10 had treatment failure...
April 20, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29676320/unveiling-opacification-of-intraocular-lens-following-a-successful-penetrating-keratoplasty-for-extensively-scarred-cornea-due-to-microbial-keratitis-after-descemet-s-stripping-automated-endothelial-keratoplasty
#9
https://www.readbyqxmd.com/read/29676313/deep-anterior-lamellar-keratoplasty-or-penetrating-keratoplasty-in-lattice-corneal-dystrophy
#10
Ritu Arora
No abstract text is available yet for this article.
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676312/outcomes-of-keratoplasty-in-lattice-corneal-dystrophy-in-a-large-cohort-of-indian-eyes
#11
Ashik Mohamed, Sunita Chaurasia, Muralidhar Ramappa, Somasheila I Murthy, Prashant Garg
Purpose: The purpose of this study is to evaluate the outcomes of keratoplasty for lattice corneal dystrophy (LCD) performed at a tertiary eye care center. Methods: A retrospective review of medical records of those patients who were clinically diagnosed to have LCD (72 eyes of 57 patients) and underwent either penetrating keratoplasty (PK, 58 eyes of 46 patients) or deep anterior lamellar keratoplasty (DALK, 14 eyes of 13 patients) between the years 1987 and 2014 was performed...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676282/influence-of-hole-transport-material-metal-contact-interface-on-perovskite-solar-cells
#12
Lei Lei, Shude Zhang, Songwang Yang, Xiaomin Li, Yu Yu, Qingzhu Wei, Zhichun Ni, Ming Li
Interfaces have a significant impact on the performance of perovskite solar cells. This work investigated the influence of hole transport material/metal contact interface on photovoltaic behaviours of perovskite solar devices. Different hole material/metal contact interfaces were obtained by depositing the metal under different conditions. High incident kinetic energy metal particles were proved to penetrate and embed into the hole transport material. These isolated metal particles in hole transport materials capture holes and increase the apparent carrier transport resistance of the hole transport layer...
April 20, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29676239/transdermal-delivery-of-at1-receptor-antagonists-reduce-blood-pressure-and-reveals-a-vasodilatory-effect-in-kidney-blood-vessels
#13
Vasso Apostolopoulos, Michaila Michalatou, Maria-Eleni Androutsou, Markos Antonopoulos, George Agelis, Anthony Zulli, Tawar Qaradakhi, John Matsoukas
BACKGROUND: The Renin Angiotensin System (RAS) is pharmacologically targeted to reduce blood pressure, and patient compliance to oral medications is a clinical issue. The mechanisms of action of angiotensin receptor blockers (ARBs) in reducing blood pressure are not well understood, and is purported to be via a reduction of angiotensin II signaling. OBJECTIVE: We aimed to develop a transdermal delivery method for ARBs (losartan potassium and valsartan) and to determine if ARBs reveal a vasodilatory effect of the novel RAS peptide, alamandine...
April 19, 2018: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29676120/-preparation-and-transdermal-permeation-of-triptolide-and-ferulic-acid-ethosomes-gel-in-vitro
#14
Ling Tao, Liang-Fei He, Yong-Mei Guan, Li-Hua Chen, Wei-Feng Zhu, Chen Jin, Lu Wu
The aim of this study was to prepare triptolide and ferulic acid ethosomes gel, investigate its transdermal permeation, and compare the results with ordinary gel and cream. Improved Franz diffusion cell method was used in the transdermal delivery experiment with rat abdominal skin as in vitro model. The receptor fluid at different time points was collected; ferulic acid concentration was determined by high performance liquid chromatography (HPLC) and triptolide concentration was determined by liquid chromatography-electrospray ionization mass spectrometry (LC-MS/MS)...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676067/significance-of-skin-barrier-dysfunction-in-atopic-dermatitis
#15
REVIEW
Byung Eui Kim, Donald Y M Leung
The epidermis contains epithelial cells, immune cells, and microbes which provides a physical and functional barrier to the protection of human skin. It plays critical roles in preventing environmental allergen penetration into the human body and responsing to microbial pathogens. Atopic dermatitis (AD) is the most common, complex chronic inflammatory skin disease. Skin barrier dysfunction is the initial step in the development of AD. Multiple factors, including immune dysregulation, filaggrin mutations, deficiency of antimicrobial peptides, and skin dysbiosis contribute to skin barrier defects...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675844/delivery-of-therapeutics-for-deep-seated-ocular-conditions-status-quo
#16
REVIEW
Hubert Nguyen, Shawn Eng, Thanh Ngo, Crispin R Dass
OBJECTIVES: There is a need for research into designing effective pharmaceutical systems for delivering therapeutic drugs to the posterior of the eye for glaucoma-related pathology, macular degeneration, diabetic retinopathy, macular oedema, retinitis and choroiditis. Conventionally, eye drops have been extensively utilised for topical drug delivery to the anterior segment of the eye, but are less effective for delivery of therapeutics to the back of the eye due to significant barriers hampering drug penetration into the target intraocular tissue...
April 19, 2018: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/29675710/salt-water-and-skin-interactions-new-lines-of-evidence
#17
REVIEW
Jose Manuel Carbajo, Francisco Maraver
In Health Resort Medicine, both balneotherapy and thalassotherapy, salt waters and their peloids, or mud products are mainly used to treat rheumatic and skin disorders. These therapeutic agents act jointly via numerous mechanical, thermal, and chemical mechanisms. In this review, we examine a new mechanism of action specific to saline waters. When topically administered, this water rich in sodium and chloride penetrates the skin where it is able to modify cellular osmotic pressure and stimulate nerve receptors in the skin via cell membrane ion channels known as "Piezo" proteins...
April 19, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29675392/efficacy-of-iontophoresis-assisted-epithelium-on-corneal-cross-linking-for-keratoconus
#18
REVIEW
Hong-Zhen Jia, Xiu-Jun Peng
Corneal cross-linking (CXL) is a noninvasive therapeutic procedure for keratoconus that is aimed at improving corneal biomechanical properties by induction of covalent cross-links between stromal proteins. It is accomplished by ultraviolet A (UVA) radiation of the cornea, which is first saturated with photosensitizing riboflavin. It has been shown that standard epithelium-off CXL (S-CXL) is efficacious, and it has been recommended as the standard of care procedure for keratoconus. However, epithelial removal leads to pain, transient vision loss, and a higher risk of corneal infection...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675373/comparison-of-the-effects-of-intravitreal-bevacizumab-and-dexamethasone-in-experimental-posterior-penetrating-eye-injury
#19
Ayse Oner, Nisa Kahraman, Saim Ozdamar, Esra Balcioglu
AIM: To compare the effects of intravitreal anti-vascular endothelial growth factor (VEGF) and dexamethasone in an experimental rabbit model of posterior penetrating ocular injury. METHODS: Thirty white New Zealand rabbits were included in the study. A posterior penetrating ocular injury was performed at the superotemporal quadrant. They were randomly divided into three groups. The rabbits in group 1 received intravitreal dexamethasone, in group 2 they received intravitreal bevacizumab and those in group 3 received intravitreal physiological saline solution in both eyes...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675334/rapid-volumetric-imaging-with-bessel-beam-three-photon-microscopy
#20
Bingying Chen, Xiaoshuai Huang, Dongzhou Gou, Jianzhi Zeng, Guoqing Chen, Meijun Pang, Yanhui Hu, Zhe Zhao, Yunfeng Zhang, Zhuan Zhou, Haitao Wu, Heping Cheng, Zhigang Zhang, Chris Xu, Yulong Li, Liangyi Chen, Aimin Wang
Owing to its tissue-penetration ability, multi-photon fluorescence microscopy allows for the high-resolution, non-invasive imaging of deep tissue in vivo ; the recently developed three-photon microscopy (3PM) has extended the depth of high-resolution, non-invasive functional imaging of mouse brains to beyond 1.0 mm. However, the low repetition rate of femtosecond lasers that are normally used in 3PM limits the temporal resolution of point-scanning three-photon microscopy. To increase the volumetric imaging speed of 3PM, we propose a combination of an axially elongated needle-like Bessel-beam with three-photon excitation (3PE) to image biological samples with an extended depth of focus...
April 1, 2018: Biomedical Optics Express
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