keyword
MENU ▼
Read by QxMD icon Read
search

Oxygen therapy safety

keyword
https://www.readbyqxmd.com/read/29343034/-a-study-on-the-effects-and-safety-of-sequential-humidified-high-flow-nasal-cannula-oxygenation-therapy-on-the-copd-patients-after-extubation
#1
J C Zhang, F X Wu, L L Meng, C Y Zeng, Y Q Lu
Objective: To investigate and compare the effect and safety of nasal high-flow oxygen therapy (HFNCO) and noninvasive ventilation (NIV) therapy after extubation in patients with chronic obstructive pulmonary disease (COPD). Methods: All COPD patients subjected to mechanical ventilation in the Emergency Intensive Unit of the First Affiliated Hospital of Zhejiang University during January 2015 to June 2016 were included in the study. The patients were divided into two groups after extubation and HFNCO and NIV were adopted on each group respectively...
January 9, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29331328/pilot-clinical-trial-of-high-flow-oxygen-therapy-in-children-with-asthma-in-the-emergency-service
#2
Yolanda Ballestero, Jimena De Pedro, Nancy Portillo, Otilia Martinez-Mugica, Eunate Arana-Arri, Javier Benito
OBJECTIVES: To assess the efficacy of high-flow nasal cannula (HFNC) oxygen therapy and safety in children with asthma and moderate respiratory failure in the emergency department (ED). STUDY DESIGN: This was a prospective randomized pilot trial of children (aged 1-14 years) presenting to a tertiary academic pediatric ED with moderate-to-severe asthma exacerbations between September 2012 and December 2015. Patients with a pulmonary score (PS) ≥6 or oxygen saturation <94% with a face mask despite initial treatment (salbutamol/ipratropium bromide and corticosteroids) were randomized to HFNC or to conventional oxygen therapy...
January 11, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29327810/nebulized-hypertonic-saline-in-infants-hospitalized-with-moderately-severe-bronchiolitis-due-to-rsv-infection-a-multicenter-randomized-controlled-trial
#3
Yoshihiko Morikawa, Masaru Miura, Megumi Y Furuhata, Saeko Morino, Tae Omori, Masahiro Otsuka, Michiko Chiga, Toshimasa Obonai, Hiroshi Hataya, Tetsuji Kaneko, Kenji Ishikura, Masataka Honda, Yukihiro Hasegawa
INTRODUCTION: The efficacy of nebulized hypertonic saline (HS) therapy for shortening hospital length of stay (LOS) or improving bronchiolitic symptoms remains controversial. Most studies enrolled small numbers of subjects and did not consider the role of respiratory syncytial virus (RSV), the most common cause of acute bronchiolitis. Our aim was to evaluate the efficacy and safety of nebulized HS therapy for acute bronchiolitis due to RSV in moderately ill hospitalized infants. MATERIALS AND METHODS: This was an open-label, multicenter, randomized controlled trial comparing a nebulized HS treatment group with a normal saline (NS) group...
January 12, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29295735/photodynamic-therapy-interventions-in-facial-photodamage-a-systematic-review
#4
G Sanclemente, V Ruiz-Cañas, J M Miranda, A P Ferrín, P A Ramirez, G N Hernandez
INTRODUCTION: Photodynamic therapy (PDT) involves the combination of a light source and a photosensitizing agent to induce tissue damage via the generation of singlet oxygen. Although topical PDT has been approved for other indications, its use in facial photodamage is uncertain. AIMS: To assess the efficacy and safety of PDT in facial skin photoaging. METHODS: All randomized clinical trials (RCTs) evaluating the efficacy and safety of any form of topical PDT for the treatment of facial photodamage (dermatoheliosis) or photoaging in patients older than 18 years, were included...
December 30, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29283682/domiciliary-high-flow-nasal-cannula-oxygen-therapy-for-stable-hypercapnic-copd-patients-a-multicenter-randomized-crossover-trial
#5
Kazuma Nagata, Takashi Kikuchi, Takeo Horie, Akira Shiraki, Takamasa Kitajima, Toru Kadowaki, Fumiaki Tokioka, Naohiko Chohnabayashi, Akira Watanabe, Susumu Sato, Keisuke Tomii
RATIONALE: A growing evidence base suggests a benefit of using high-flow nasal cannula oxygen therapy (HFNC) in the acute setting. However, the clinical benefit of domiciliary use of HFNC in patients with chronic hypercapnic respiratory failure due to chronic obstructive pulmonary disease (COPD) remains unclear. OBJECTIVES: To evaluate the efficacy and safety of HFNC use in stable COPD patients. METHODS: This was a multicenter, randomized crossover trial comparing HFNC plus long-term oxygen therapy (HFNC/LTOT) with LTOT-only in 32 adults with stable hypercapnic COPD...
December 28, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29248141/impact-of-volume-status-and-volume-therapy-on-the-kidney
#6
REVIEW
David A Roberts, Andrew D Shaw
Volume resuscitation to correct hypotension in surgical and critically ill patients is a common practice. Available evidence suggests that iatrogenic volume overload is associated with worse outcomes in established acute kidney injury. Intraoperative arterial hypotension is associated with postoperative renal dysfunction, and prompt correction with fluid management protocols that combine inotrope infusions with volume therapy targeted to indices of volume responsiveness should be considered. From the perspective of renal function, the minimum amount of intravenous fluid required to maintain perfusion and oxygen delivery is desirable...
September 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29246130/enteral-vitamin-a-for-reducing-severity-of-bronchopulmonary-dysplasia-in-extremely-preterm-infants-a-randomised-controlled-trial
#7
Abhijeet Rakshasbhuvankar, Sanjay Patole, Karen Simmer, J Jane Pillow
BACKGROUND: Intramuscular vitamin A supplementation decreases the risk of bronchopulmonary dysplasia (BPD) in very-low-birth-weight preterm infants without significant adverse effects. However, intramuscular vitamin A supplementation is not widely accepted because of the discomfort and risk of trauma associated with repeated injections. Enteral vitamin A supplementation has not been studied adequately in the clinical trials. Enterally administered water-soluble vitamin A is absorbed better than the fat-soluble form...
December 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29238951/pharmacologic-targeting-of-red-blood-cells-to-improve-tissue-oxygenation
#8
James D Reynolds, Trevor Jenkins, Faisal Matto, Ryan Nazemian, Obada Farhan, Nathan Morris, John M Longphre, Douglas T Hess, Richard E Moon, Claude A Piantadosi, Jonathan S Stamler
Disruption of microvascular blood flow is a common cause of tissue hypoxia in disease, yet no therapies are available that directly target the microvasculature to improve tissue oxygenation. Red blood cells (RBCs) auto-regulate blood flow through S-nitroso-hemoglobin (SNO-Hb)-mediated export of nitric oxide (NO) bioactivity. We therefore tested the idea that pharmacological enhancement of RBCs using the S-nitrosylating agent ethyl nitrite (ENO) may provide a novel approach to improve tissue oxygenation. Serial ENO dosing was carried out in sheep (1-400 ppm) and humans (1-100 ppm) at normoxia and at reduced FiO2 ...
December 14, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29233239/perfluorocarbon-in-delayed-recompression-with-a-mixed-gender-swine-model-of-decompression-sickness
#9
William A Cronin, Aaron A Hall, Charles R Auker, Richard T Mahon
INTRODUCTION: Perfluorocarbons (PFC) are fluorinated hydrocarbons that dissolve gases to a much greater degree than plasma and hold promise in treating decompression sickness (DCS). The efficacy of PFC in a mixed gender model of DCS and safety in recompression therapy has not been previously explored. METHODS: Swine (25 kg; N = 104; 51 male and 53 female) were randomized into normal saline solution (NSS) or PFC emulsion treatment groups and subjected to compression on air in a hyperbaric chamber at 200 fsw for 31 min...
January 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29233198/clinical-efficacy-and-safety-of-switch-from-bosentan-to-macitentan-in-children-and-young-adults-with-pulmonary-arterial-hypertension
#10
Ebru Aypar, Dursun Alehan, Tevfik Karagöz, Hayrettin Hakan Aykan, İlker Ertugrul
BACKGROUND: Macitentan is an orally active, potent, dual endothelin receptor antagonist and is the only registered treatment for pulmonary arterial hypertension that significantly reduced morbidity and mortality in a long-term event-driven study. Aim Few studies compared the clinical efficacy and safety of switch from bosentan to macitentan only in adult patients with pulmonary arterial hypertension. We aimed to evaluate the clinical efficacy and safety of switch from bosentan to macitentan in children and young adults...
December 13, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29230179/transplacental-nutrient-transport-mechanisms-of-intrauterine-growth-restriction-in-rodent-models-and-humans
#11
REVIEW
Elke Winterhager, Alexandra Gellhaus
Although the causes of intrauterine growth restriction (IUGR) have been intensively investigated, important information is still lacking about the role of the placenta as a link from adverse maternal environment to adverse pregnancy outcomes of IUGR and preterm birth. IUGR is associated with an increased risk of cardiovascular, metabolic, and neurological diseases later in life. Determination of the most important pathways that regulate transplacental transport systems is necessary for identifying marker genes as diagnostic tools and for developing drugs that target the molecular pathways...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29217475/in-vitro-drug-release-and-in-vivo-safety-of-vitamin-e-and-cysteamine-loaded-contact-lenses
#12
Phillip Dixon, Richard C Fentzke, Arnab Bhattacharya, Aditya Konar, Sarbani Hazra, Anuj Chauhan
Cystinosis is an orphan disease caused by a genetic mutation that leads to deposition of cystine crystals in many organs including cornea. Ophthalmic manifestation of the disease can be treated with hourly instillation of cysteamine eye drops. The hourly eye drop instillation is tedious to the patients leading to poor compliance and additionally, significant degradation of the drug occurs within one week of opening the bottle, which further complicates this delivery approach. This paper focuses on designing a contact lens to treat the disease with improved efficacy compared to eye drops, and also exploring safety of the drug eluding contact lens in an animal model...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29161007/polymer-based-technologies-for-sensing-applications
#13
Wildemar Stefanio Pereira Carvalho, Menglian Wei, Nduka Ikpo, Yongfeng Gao, Michael J Serpe
Reports in the literature on the development of new chemical sensing technologies have been growing steadily in number for years. For example, a Web of Science topic search using the term "Chemical Sensing" revealed that over 8,000 papers were published in 2015-2017, with over 40,000 citations to those papers. In this review, we focus on highlighting recent examples of chemical sensing related to human health (e.g., disease diagnosis, health monitoring, and water/food safety), and for environmental monitoring...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29154687/pyruvate-enhancement-of-cardiac-performance-cellular-mechanisms-and-clinical-application
#14
Robert T Mallet, Albert H Olivencia-Yurvati, Rolf Bünger
Cardiac contractile function is adenosine-5'-triphosphate (ATP)-intensive, and the myocardium's high demand for oxygen and energy substrates leaves it acutely vulnerable to interruptions in its blood supply. The myriad cardioprotective properties of the natural intermediary metabolite pyruvate make it a potentially powerful intervention against the complex injury cascade ignited by myocardial ischemia-reperfusion. A readily oxidized metabolic substrate, pyruvate augments myocardial free energy of ATP hydrolysis to a greater extent than the physiological fuels glucose, lactate and fatty acids, particularly when it is provided at supra-physiological plasma concentrations...
January 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29149867/efficacy-and-safety-of-nasal-high-flow-oxygen-in-copd-patients
#15
Helene Vogelsinger, Michael Halank, Silke Braun, Heinrike Wilkens, Thomas Geiser, Sebastian Ott, Armin Stucki, Christian M Kaehler
BACKGROUND: Nasal high-flow oxygen therapy (HFOT) is a novel treatment option for patients suffering from acute or chronic respiratory failure. Aim of our study was to compare safety and efficacy of HFOT with those of conventional oxygen treatment (COT) in normo- and hypercapnic COPD patients. METHODS: A single cohort of 77 clinically stable hypoxemic patients with an indication for long-term oxygen treatment (LTOT) with or without hypercapnia successively received COT and HFOT for 60 min each, including oxygen adaption and separated by a 30 min washout phase...
November 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29132229/hyperbaric-oxygen-therapy-in-the-treatment-of-acute-severe-traumatic-brain-injury-a-systematic-review
#16
Samuel Daly, Maxwell Thorpe, Sarah B Rockswold, Molly Hubbard, Thomas A Bergman, Uzma Samadani, Gaylan Rockswold
There has been no major advancement in a quarter of a century for the treatment of acute severe traumatic brain injury (TBI). This review summarizes 40 years of clinical and pre-clinical research on the treatment of acute TBI with hyperbaric oxygen therapy (HBO2) in the context of an impending National Institute of Neurologic Disorders and Stroke (NINDS)-funded, multicenter, randomized, adaptive Phase II clinical trial - the Hyperbaric Oxygen Brain Injury Treatment (HOBIT) trial. Thirty studies (8 clinical and 22 pre-clinical) that administered HBO2 within 30 days of a TBI were identified from PubMed searches...
November 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29131746/topical-oxygen-therapy-promotes-the-healing-of-chronic-diabetic-foot-ulcers-a-pilot-study
#17
P D Hayes, N Alzuhir, G Curran, I M Loftus
OBJECTIVE: Interventions that can heal or reduce diabetic foot ulcer (DFU) size may reduce the incidence of infection and amputation, and reduce associated social and economic costs. Many chronic wounds exhibit a degree of hypoxia and this leads to a reduction in healing processes including cell division and differentiation, angiogenesis, infection prevention, and collagen production. The aim of this pilot study was to assess the effects of a device supplying continuous oxygen ambulatory therapy on healing in chronic DFUs...
November 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29121334/pharmacotherapy-of-apnea-by-cannabimimetic-enhancement-the-pace-clinical-trial-effects-of-dronabinol-in-obstructive-sleep-apnea
#18
David W Carley, Bharati Prasad, Kathryn J Reid, Roneil Malkani, Hryar Attarian, Sabra M Abbott, Boris Vern, Hui Xie, Chengbo Yuan, Phyllis Zee
Study Objectives: There remains an important and unmet need for fully effective and acceptable treatments in obstructive sleep apnea (OSA). At present, there are no approved drug treatments. Dronabinol has shown promise for OSA pharmacotherapy in a small dose-escalation pilot study. Here, we present initial findings of the Phase II PACE (Pharmacotherapy of Apnea by Cannabimimetic Enhancement) trial, a fully-blinded parallel groups, placebo-controlled randomized trial of dronabinol in patients with moderate or severe OSA...
November 7, 2017: Sleep
https://www.readbyqxmd.com/read/29117615/safety-of-metformin-therapy-in-patients-with-type-2-diabetes-living-on-an-oxygen-deficient-plateau-tibet-china
#19
Xuemei Lv, Qian Ren, Lingli Zhou, Yanyan Geng, Jia Song, A Mina, Basang Puchi, Senlin Yang, Shuyou Meng, Lihui Yang
Background In the general population, the absolute risk of lactic acidosis in patients treated with metformin appears to be low. However, in the Tibetan plateau, an extreme oxygen-deficient environment, there are no data available concerning the safety of metformin. The aim of our study is to assess the safety of metformin in people of the plateau area. Methods We conducted an observational cross-sectional study in Tibet. All the 166 subjects were divided into two groups: T2DM+metformin group and T2DM group...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29101270/balloon-pulmonary-angioplasty-for-chronic-thromboembolic-pulmonary-hypertension-results-of-a-multicenter-registry
#20
Aiko Ogawa, Toru Satoh, Tetsuya Fukuda, Koichiro Sugimura, Yoshihiro Fukumoto, Noriaki Emoto, Norikazu Yamada, Atsushi Yao, Motomi Ando, Hitoshi Ogino, Nobuhiro Tanabe, Ichizo Tsujino, Masayuki Hanaoka, Kenji Minatoya, Hiroshi Ito, Hiromi Matsubara
BACKGROUND: Balloon pulmonary angioplasty (BPA) is an alternative therapy for patients with chronic thromboembolic pulmonary hypertension who are ineligible for pulmonary endarterectomy-the standard therapy. Currently, most reported results of BPA are from relatively small cohorts treated at single centers. The present study evaluated the safety and efficacy of BPA for chronic thromboembolic pulmonary hypertension based on a multicenter registry. METHODS AND RESULTS: A total of 308 patients (62 men and 246 women; mean age, 61 years) underwent 1408 procedures at 7 institutions in Japan...
November 2017: Circulation. Cardiovascular Quality and Outcomes
keyword
keyword
15353
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"