keyword
https://read.qxmd.com/read/38517465/imipenem-relebactam-pharmacokinetics-in-critically-ill-patients-supported-on-extracorporeal-membrane-oxygenation
#1
JOURNAL ARTICLE
Andrew J Fratoni, Abigail K Kois, Jason A Gluck, David P Nicolau, Joseph L Kuti
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a life-saving modality but has the potential to alter the pharmacokinetics (PK) of antimicrobials. Imipenem/cilastatin/relebactam is an antibiotic with utility in treating certain multi-drug resistant Gram-negative infections. Herein, we describe the population pharmacokinetics of imipenem and relebactam in critically ill patients supported on ECMO. METHODS: Patients with infection supported on ECMO received 4-6 doses of imipenem/cilastatin/relebactam per current prescribing information based on estimated creatinine clearance...
March 22, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38500152/characteristics-associated-with-sf-36-in-alpha-1-antitrypsin-deficiency-associated-copd-a-cross-sectional-analysis
#2
JOURNAL ARTICLE
Radmila Choate, Kristen E Holm, Robert A Sandhaus, David M Mannino, Charlie Strange
BACKGROUND: Generic measures of health-related quality of life (HRQoL), such as the 36-Item Short Form Survey (SF-36), are widely used in assessing chronic conditions. These tools have an advantage over disease-specific instruments, as they allow comparisons across different health conditions and with the general population. In alpha-1 antitrypsin deficiency (AATD)-associated chronic obstructive pulmonary disease (COPD), HRQoL research remains scarce. This cross-sectional study evaluates the factors associated with HRQoL in a cohort of patients with AATD-associated COPD...
March 18, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38493433/the-impact-of-pulmonary-hydatid-cyst-rupture-on-covid-19-symptom-severity
#3
JOURNAL ARTICLE
Abdol Sattar Pagheh, Hossein Pazoki, Ghodsiyeh Azarkar, Effat Alemzadeh, Jafar Hajavi, Masood Ziaee
BACKGROUND: Co-infection with other microorganisms such as parasites in patients with COVID-19 can affect the clinical outcome and require prompt diagnosis and appropriate therapy. CASE PRESENTATION: We present a case of an adult male with chest pain, dyspnea, cough, diplopia, and anorexia who was confirmed to have acute COVID-19 pneumonia. 2 weeks prior to admission, a hydatid lung cyst was identified on examination, but the patient refused surgery. Thoracoabdominal computed tomography (CT) revealed a rupture of the lung hydatid cyst and co-infection with COVID-19...
March 17, 2024: Acta Parasitologica
https://read.qxmd.com/read/38492790/synergistic-amelioration-between-ligusticum-striatum-dc-and-borneol-against-cerebral-ischemia-by-promoting-astrocytes-mediated-neurogenesis
#4
JOURNAL ARTICLE
Xiaofeng Zhang, Fengjiao Deng, Xueqing Wang, Fanghan Liu, Yue Zhu, Bin Yu, Ming Ruan
ETHNOPHARMACOLOGICAL RELEVANCE: Ligusticum chuanxiong Hort (LCH), with the accepted name of Ligusticum striatum DC in "The Plant List" database, is a widely used ethnomedicine in treating ischemic stroke, and borneol (BO) is usually prescribed with LCH for better therapy. Our previous study confirmed their synergistic effect on neurogenesis against cerebral ischemia. However, the underlying mechanism is still unclear. AIM OF THE STUDY: More and more evidence indicated that astrocytes (ACs) might be involved in the modulation of neurogenesis via polarization reaction...
March 15, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38490735/clinical-implementation-of-automated-o-2-titration-in-a-tertiary-care-hospital
#5
JOURNAL ARTICLE
Pierre-Alexandre Bouchard, Geneviève Parent-Racine, Cassiopée Paradis-Gagnon, Mathieu Simon, Yves Lacasse, François Lellouche, François Maltais
Background: When treating acute respiratory failure, both hypoxemia and hyperoxemia should be avoided. SpO2 should be monitored closely and O2 flows adjusted accordingly. Achieving this goal might be easier with automated O2 titration compared to manual titration of fixed-flow O2 We evaluated the feasibility of using an automated O2 titration device in subjects treated for acute hypoxemic respiratory failure in a tertiary care hospital. Methods: Healthcare workers received education and training about oxygen therapy and were familiarized with an automated O2 titration device (FreeO2, Oxynov, Quebec City, Canada)...
March 15, 2024: Respiratory Care
https://read.qxmd.com/read/38417865/stss-by-streptococcus-pyogenes-emm22-genotype-accompanied-by-csrs-mutation-a-case-report
#6
JOURNAL ARTICLE
Kaoru Ogawa, Jiro Kamiyama, Tadayoshi Ikebe, Shigemasa Taguchi, Kazuya Kiyota
The patient was a 22-year-old woman with no comorbidities who was transferred to our hospital due to cardiac arrest. Treatment enabled return to spontaneous circulation in the patient before arriving at the hospital. At the hospital, the patient's vital signs were unstable. Vasopressors and hyperhydration therapy were administered. Computed Tomography (CT) showed no remarkable change that caused the cardiac arrest. Antibiotics were prescribed after a blood culture exam. The patient was admitted to the ICU. In the ICU, the high-capacity vasopressors, hyperhydration therapy and transfusion of fresh frozen plasma were continued...
February 29, 2024: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/38324171/patient-use-patterns-of-portable-oxygen-concentrators
#7
JOURNAL ARTICLE
Stanislav Glezer, Michael W Hess, Alan K Kamada
INTRODUCTION: Portable oxygen concentrators (POCs) are medical devices that provide supplemental oxygen to patients requiring long-term oxygen therapy. However, little information is available on day-to-day patterns of how or even whether patients actively switch between their POC mobility features and flow setting options. METHODS: A retrospective analysis was conducted to assess POC usage among patients who used an Inogen One G5 POC in the USA. This study aimed (1) to describe the patterns of use of POCs, (2) to analyze their compatibility with the prescribed oxygen therapy settings, and (3) to demonstrate the contribution of POC usage to get a standardized long-term oxygen therapy (LTOT)...
February 7, 2024: Pulmonary Therapy
https://read.qxmd.com/read/38321506/effect-of-exercise-on-functional-capacity-and-body-weight-for-people-with-hypertension-type-2-diabetes-or-cardiovascular-disease-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#8
JOURNAL ARTICLE
Anupa Rijal, Tara Ballav Adhikari, Sarmila Dhakal, Mathias Maagaard, Reza Piri, Emil Eik Nielsen, Dinesh Neupane, Janus Christian Jakobsen, Michael Hecht Olsen
BACKGROUND: Hypertension, type 2 diabetes, and cardiovascular disease affect the activities of daily living at varying degree. While the effects of aerobic exercise on functional capacity are well-documented, the extent of change for different types of exercise in these chronic conditions remains unexplored. Additionally, there is conflicting evidence regarding the role of exercise in reducing body weight. METHODS: We conducted systematic review with meta-analysis and trial sequential analysis and searched various databases from inception to July 2020...
February 7, 2024: BMC Sports Science, Medicine and Rehabilitation
https://read.qxmd.com/read/38290537/individualized-homeopathic-and-organopathic-supportive-management-of-sickle-cell-disorder-a-case-series-of-six-patients-from-a-particularly-vulnerable-tribal-group-in-india
#9
JOURNAL ARTICLE
Nisanth K M Nambison, Narendra Sharma, Abhishek D Dwivedi, Nisha Chakravarty
BACKGROUND:  Sickle cell disorder (SCD) is a hereditary blood disease characterized by an abnormality in the oxygen-carrying protein hemoglobin present in red blood cells. Genetic abnormality causes these cells to become sickle-shaped, with shorter lifespan. Vaso-occlusive crisis is a major symptom of SCD: it is a sudden and severe episode of pain, and occurs when sickle-shaped cells block blood flow. This blockage can lead to tissue damage, inflammation and pain. OBJECTIVES:  This case series aims to observe the clinical outcomes from prescribing individualized homeopathic medicines along with organopathic supportive medicine in the management of SCD through the analysis of case studies of six patients from a particularly vulnerable tribal group (PVTG) in India that manifests genetic predisposition for the disease...
January 30, 2024: Homeopathy: the Journal of the Faculty of Homeopathy
https://read.qxmd.com/read/38250337/fatal-case-of-pneumocystis-jirovecii-pneumonia-pjp-during-treatment-for-drug-rash-with-eosinophilia-and-systemic-symptoms-dress-syndrome
#10
Chaoe Zhou, Jun Li, Fude Zhou, Lei Huang, Xinmin Liu, Haichao Li
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an acute, rare and potentially fatal drug reaction. To date, limited studies have reported secondary Pneumocystis jirovecii pneumonia (PJP) infection during the treatment of DRESS syndrome. A 53-year-old man was admitted to the hospital due to a persistent fever lasting for 5 days. He had a medical history of hypertension, psoriasis, urticaria, and had recently been treated with carbamazepine for nerve spasm two weeks ago. After admission, the patient presented with a high fever accompanied by chills, abdominal pain, bilateral upper limb muscle pain, and generalized lymph nodes enlargement...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38245397/haematocrit-monitoring-and-blood-volume-estimation-during-continuous-renal-replacement-therapy
#11
JOURNAL ARTICLE
Ian Baldwin, Akinori Maeda, Rinaldo Bellomo, Emily See
BACKGROUND: Continuous haemoglobin, venous blood oxygen saturation, and haematocrit (Hct) monitoring is currently not applied during continuous renal replacement therapy (CRRT). Such Hct monitoring enables estimation of changes in blood volume as percentage change (ΔBV%) from therapy start time and is incorporated into intermittent haemodialysis machines but not CRRT machines despite its potential to optimise fluid management in CRRT patients. METHODS: To overcome this problem, we used a standalone monitor (CRIT-LINE®IV, Fresenius Medical Care, Concord, USA) with an associated in-line blood chamber (CRIT-LINE®IV Blood Chamber, Fresenius Medical Care, Concord, USA) and designed our own adaptor connection piece (TekMed and Morriset, Melbourne and Brisbane, Australia) to allow these readings at the vascular access outflow and recorded data for estimated Hct and derived ΔBV% during CRRT...
January 19, 2024: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://read.qxmd.com/read/38221775/unraveling-the-neuroprotective-mechanisms-of-naltrexone-against-aluminum-induced-neurotoxicity
#12
JOURNAL ARTICLE
Sonia Sanajou, Anil Yirün, Deniz Arca Çakır, Göksun Demirel, Gönül Şahin, Pinar Erkekoğlu, Terken Baydar
Aluminum (Al) is a known neurotoxic trace element linked to Alzheimer's disease (AD). Naltrexone, an opioid antagonist, has shown promising effects in reducing neuroinflammation at lower doses than those prescribed for addiction. This study aimed to determine the neuroprotective effects of naltrexone on Al-induced neurotoxicity in an in vitro AD model. The SH-SY5Y cells were first cultivated in a standard growth medium. Subsequently, the cells were induced to differentiate by decreasing the concentration of fetal bovine serum and introducing retinoic acid (RA) into the culture media...
January 14, 2024: Drug and Chemical Toxicology
https://read.qxmd.com/read/38188270/kinetics-of-il-6-c-reactive-protein-and-fibrinogen-levels-in-covid-19-outpatients-who-evolved-to-hypoxemia
#13
JOURNAL ARTICLE
Sérgio Paulo de Mello Mendes-Filho, Rebeca de Souza Pinheiro, Fernanda Simão Martins, Paulo Jose Giroldi, Raul Honorato E Melo, Edcleia Lopes de Oliveira, Anibal Borin Dos Santos, Dayse Cristina Oliveira Medeiros, Jéssica Amaral Lopes, Yury Oliveira Chaves, Juliana Pavan Zuliani, Paulo Afonso Nogueira
INTRODUCTION: Despite the efficacy of the COVID-19, the search for improvements in the management of severe/critical cases continues to be important. The aim is to demonstrate the kinetics of 4 serological markers in patients with COVID-19 who evolved in hypoxemia. METHODS: From June to December 2020, the Health Secretariat of Rondônia State, Brazil, established a home medical care service team (HMCS) that provided clinical follow-up for health professionals and military personnel with COVID-19...
2024: Clinical pathology
https://read.qxmd.com/read/38176902/home-oxygen-after-hospitalization-for-covid-19-results-from-the-multicenter-oxford-study
#14
JOURNAL ARTICLE
Michael B Freedman, Yoo Jin Kim, Ramandeep Kaur, Bijal V Jain, Ayodeji O Adegunsoye, Yu-Che Chung, Julie A DeLisa, Jessica M Gardner, Howard S Gordon, Jared A Greenberg, Malvika Kaul, Nader Khouzam, Stephanie L Labedz, Babak Mokhlesi, Jacob Rintz, Israel Rubinstein, Analisa Taylor, David L Vines, Lubna Ziauddin, Lynn B Gerald, Jerry A Krishnan
Background: In the first months of the pandemic, prior to the introduction of proven-effective treatments, 15 to 37% of patients hospitalized with COVID-19 were discharged on home oxygen. After proven-effective treatments for acute COVID-19 were established by evidence-based guidelines, little is known about home oxygen requirements following hospitalization for COVID-19. Methods: This was a retrospective, multicenter cohort study of patients hospitalized for COVID-19 between October 2020 and September 2021 at three academic health centers...
January 4, 2024: Respiratory Care
https://read.qxmd.com/read/38176866/use-of-oxygen-ozone-therapy-to-improve-the-effectiveness-of-antibiotic-treatment-on-infected-arthroplasty-protocol-for-a-superiority-open-label-multicentre-randomised-parallel-trial
#15
JOURNAL ARTICLE
Fidelia Cascini, Marianno Franzini, Arnaldo Andreoli, Alfonso Manzotti, Chiara Cadeddu, Gianluigi Quaranta, Andrea Gentili, Walter Ricciardi
INTRODUCTION: Surgical site infections still remain a major public health challenge and have become an increasing universal risk, especially for the implantation of orthopaedic devices.Unfortunately, the discovery and increasingly widespread use (especially the misuse) of antibiotics have led to the rapid appearance of antibiotic-resistant strains today; more and more infections are caused by microorganisms that fail to respond to conventional treatments.Oxygen-ozone therapy has been extensively used and studied for decades across various potential medical applications and has provided consistent effects with minimal side effects...
January 4, 2024: BMJ Open
https://read.qxmd.com/read/38166547/venous-arterial-extracorporeal-membrane-oxygenation-for-psittacosis-pneumonia-complicated-with-cardiogenic-shock-case-report-and-literature-review
#16
REVIEW
Yanting Zhang, Hongtao Hu, Ying Xu, Yi Chen, Biao Liu, Jun Chen, Wenfang Nie, Si Zhong, Jing Ma, Chang Liu
INTRODUCTION: Dilated cardiomyopathy (DCM) is characterized by the enlargement of the left ventricle or biventricular, accompanied by myocardial systolic dysfunction. Chlamydia psittacosis (CP) is a zoonotic pathogen, which can cause severe pneumonia, respiratory failure, and acute organ dysfunction. The deterioration of DCM caused by CP infection is extremely rare, and few cases of successful management were reported. CASE PRESENTATION: We reported a 67-year-old male patient with DCM and chronic heart failure...
January 2, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38154912/automated-audit-of-hospital-oxygen-use-devised-during-the-covid-19-pandemic
#17
JOURNAL ARTICLE
Ronan O'Driscoll, Nawar Diar Bakerly
BACKGROUND: The British Thoracic Society (BTS) has organised intermittent audits of hospital oxygen use in UK hospitals since 2008. Manual audits are time-consuming and subject to human errors. Oxygen prescribing and bedside observations including National Early Warning Scores (NEWS2 scores) are undertaken within an integrated electronic medical record (EMR) at this hospital. METHODS: The hospital's Business Information team were commissioned in late 2019 to devise a bespoke automated audit of oxygen prescribing and use...
December 28, 2023: BMJ Open Respiratory Research
https://read.qxmd.com/read/38143567/extended-release-tofacitinib-therapy-for-a-mda5-antibody-positive-amyopathic-dermatomyositis-patient-with-early-stage-interstitial-lung-disease
#18
Chrong-Reen Wang, Wei-Chieh Lin, Tak-Wah Wong
INTRODUCTION: In East Asia, more than half of patients with amyopathic dermatomyositis (ADM) have interstitial lung disease (ILD). There is up to 50% 6-month mortality in MDA5-positive ILD refractory to corticosteroid (CS) combined with immunosuppressant therapy. PATIENT DETAILS: A 39-year-old local woman had a 1-month history of reddish-purple discoloration around the eyelids (heliotrope rash), and erythematous areas on the upper back and posterior neck (shawl sign) as well as on the front of her chest (V sign), followed by dry cough and mild dyspnea for 1 week...
2023: ImmunoTargets and Therapy
https://read.qxmd.com/read/38142304/high-protein-intake-and-nitrogen-balance-in-patients-receiving-venovenous-extracorporeal-membrane-oxygenation-a-descriptive-cohort-study
#19
JOURNAL ARTICLE
Stacy L Pelekhaty, Meredith Peiffer, Joshua L Leibowitz, Ali Tabatabai
BACKGROUND: This retrospective cohort study sought to describe the ability of high protein regimens to achieve nitrogen equilibrium in patients receiving venovenous extracorporeal membrane oxygenation (VV ECMO). METHODS: Patients aged ≥18 years with a documented nitrogen balance study (NB) on VV ECMO between February 2018 and December 2021 were included. Studies with incomplete 24-h urine collections or changes in blood urea nitrogen ≥10 mg/dl were excluded...
February 2024: JPEN. Journal of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/38085143/the-effect-of-oral-montelukast-in-controlling-asthma-attacks-in-children-a-randomized-double-blind-placebo-control-study
#20
RANDOMIZED CONTROLLED TRIAL
Mohsen Jafari, Masoomeh Sobhani, Kambiz Eftekhari, Armen Malekiantaghi, Mohammad Gharagozlou, Alireza Shafiei
Oral Montelukast is recommended as maintenance therapy for persistent asthma, but there is controversy regarding its effectiveness in controlling asthma attacks. The present study was conducted to investigate the clinical efficacy of oral Montelukast for asthma attacks in children. This study was conducted as a double-blind placebo-controlled clinical trial on 80 children aged 1-14 years with asthma who were admitted to the emergency department of Bahrami Children's Hospital (Tehran, Iran) during one year. Patients were randomly divided into case and control groups...
October 29, 2023: Iranian Journal of Allergy, Asthma, and Immunology
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