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Oxygen delivery devices

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https://www.readbyqxmd.com/read/29734208/improved-lung-recruitment-and-oxygenation-during-mandatory-ventilation-with-a-new-expiratory-ventilation-assistance-device-a-controlled-interventional-trial-in-healthy-pigs
#1
Johannes Schmidt, Christin Wenzel, Marlene Mahn, Sashko Spassov, Heidi Cristina Schmitz, Silke Borgmann, Ziwei Lin, Jörg Haberstroh, Stephan Meckel, Sebastian Eiden, Steffen Wirth, Hartmut Buerkle, Stefan Schumann
BACKGROUND: In contrast to conventional mandatory ventilation, a new ventilation mode, expiratory ventilation assistance (EVA), linearises the expiratory tracheal pressure decline. OBJECTIVE: We hypothesised that due to a recruiting effect, linearised expiration oxygenates better than volume controlled ventilation (VCV). We compared the EVA with VCV mode with regard to gas exchange, ventilation volumes and pressures and lung aeration in a model of peri-operative mandatory ventilation in healthy pigs...
May 4, 2018: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29724390/the-impact-of-carrying-supplemental-oxygen-on-exercise-capacity-and-dyspnea-in-patients-with-interstitial-lung-disease
#2
Deepa Ramadurai, Maeveen Riordan, Bridget Graney, Tara Churney, Amy L Olson, Jeffrey J Swigris
BACKGROUND: May patients with interstitial lung disease (ILD) require supplementary oxygen (O2 ) therapy to maintain normoxia. However, ambulatory O2 delivery devices are constraining and cumbersome. The physiologic and symptomatic impact of these devices on ILD patients is unknown. METHODS: We conducted a prospective study of 30 clinically stable ILD patients (with varying disease severity), half of whom used O2 at baseline. Each subject completed two six-minute walk tests (6MWTs); for O2 users, one walk was completed while wearing a backpack (weight 7...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29696089/new-routes-to-the-functionalization-patterning-and-manufacture-of-graphene-based-materials-for-biomedical-applications
#3
A De Sanctis, S Russo, M F Craciun, A Alexeev, M D Barnes, V K Nagareddy, C D Wright
Graphene-based materials are being widely explored for a range of biomedical applications, from targeted drug delivery to biosensing, bioimaging and use for antibacterial treatments, to name but a few. In many such applications, it is not graphene itself that is used as the active agent, but one of its chemically functionalized forms. The type of chemical species used for functionalization will play a key role in determining the utility of any graphene-based device in any particular biomedical application, because this determines to a large part its physical, chemical, electrical and optical interactions...
June 6, 2018: Interface Focus
https://www.readbyqxmd.com/read/29683388/hematocrit-and-impact-of-transfusion-in-patients-receiving-extracorporeal-life-support
#4
Justyna Swol, Christopher Marschall, Justus T Strauch, Thomas A Schildhauer
INTRODUCTION: Increasing the hematocrit is considered to increase oxygen delivery to the patient, especially when hypoxic conditions exist and the patient may become more stable. The aim of this study was to evaluate the relationship between hematocrit and hospital mortality via subgroup analyses of trauma and non-trauma patients. METHODS: The hospital length of stay (LOS) and LOS in the intensive care unit (ICU) and hospital after extracorporeal life support (ECLS) treatment of 81 patients were analyzed and compared...
April 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29590143/short-term-evaluation-of-respiratory-effort-by-premature-infants-supported-with-bubble-nasal-continuous-airway-pressure-using-seattle-pap-and-a-standard-bubble-device
#5
Stephen E Welty, Craig G Rusin, Larissa I Stanberry, George T Mandy, Alfred L Gest, Jeremy M Ford, Carl H Backes, C Peter Richardson, Christopher R Howard, Thomas N Hansen, Charles V Smith
BACKGROUND: Almost one million prematurely born infants die annually from respiratory insufficiency, predominantly in countries with limited access to respiratory support for neonates. The primary hypothesis tested in the present study was that a modified device for bubble nasal continuous positive airway pressure (Bn-CPAP) would provide lower work of spontaneous breathing, estimated by esophageal pressure-rate products. METHODS: Infants born <32 weeks gestation and stable on Bn-CPAP with FiO2 <0...
2018: PloS One
https://www.readbyqxmd.com/read/29572879/patient-specific-atrial-hemodynamics-of-a-double-lumen-neonatal-cannula-in-correct-caval-position
#6
Jamil Muhammad, Mohammad Rezaeimoghaddam, Bilgesu Cakmak, Reza Rasooli, Ece Salihoglu, Yahya Yıldız, Kerem Pekkan
Clinical success of pediatric veno-venous (VV) extracorporeal membrane oxygenation (ECMO) is associated with the double lumen cannula cardiovascular device design as well as its anatomic orientation in the atrium. The positions of cannula ports with respect to the vena cavae and the tricuspid valve are believed to play a significant role on device hemodynamics. Despite various improvements in ECMO catheters, especially for the neonatal and congenital heart patients, it is still challenging to select a catalogue size that would fit to most patients optimally...
March 23, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29530362/the-optiflow%C3%A2-interface-for-chronic-cpap-use-in-children
#7
C Overbergh, S Installe, A Boudewyns, K Van Hoorenbeeck, S L Verhulst
Continuous positive airway pressure (CPAP) is being increasingly used in children of all age ranges. The limited number of commercially available masks especially in infants and young children may complicate its use and compliance. In this report, we describe our experience with the use of the Optiflow™ (Fisher and Paykel Healthcare) Nasal Cannula attached to a regular CPAP device in the setting of chronic CPAP use. This interface consists of a nasal cannula and was originally designed for the delivery of high-flow oxygen therapy...
April 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29506579/high-flow-nasal-oxygen-vs-standard-oxygen-therapy-in-immunocompromised-patients-with-acute-respiratory-failure-study-protocol-for-a-randomized-controlled-trial
#8
Elie Azoulay, Virginie Lemiale, Djamel Mokart, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, Jean Reignier, Anabelle Stoclin, Guillaume Louis, Jean-Michel Constantin, Julien Mayaux, Florent Wallet, Achille Kouatchet, Vincent Peigne, Pierre Perez, Christophe Girault, Samir Jaber, Johanna Oziel, Martine Nyunga, Nicolas Terzi, Lila Bouadma, Christine Lebert, Alexandre Lautrette, Naike Bigé, Jean-Herlé Raphalen, Laurent Papazian, Antoine Rabbat, Michael Darmon, Sylvie Chevret, Alexandre Demoule
BACKGROUND: Acute respiratory failure (ARF) is the leading reason for intensive care unit (ICU) admission in immunocompromised patients. High-flow nasal oxygen (HFNO) therapy is an alternative to standard oxygen. By providing warmed and humidified gas, HFNO allows the delivery of higher flow rates via nasal cannula devices, with FiO2 values of nearly 100%. Benefits include alleviation of dyspnea and discomfort, decreased respiratory distress and decreased mortality in unselected patients with acute hypoxemic respiratory failure...
March 5, 2018: Trials
https://www.readbyqxmd.com/read/29484605/the-effects-of-systemic-oxygenation-on-cerebral-oxygen-saturation-and-its-relationship-to-mixed-venous-oxygen-saturation-a-prospective-observational-study-comparison-of-the-invos-and-foresight-elite-cerebral-oximeters
#9
Christian Schmidt, Matthias Heringlake, Patrick Kellner, Astrid Ellen Berggreen, Holger Maurer, Sebastian Brandt, Bence Bucsky, Michael Petersen, Efstratios I Charitos
PURPOSE: The present study aimed to test the hypothesis that cerebral oxygen saturation (ScO2 ) measurements with the INVOS-5100-C and the ForeSight-Elite cerebral oximeters vary in their correlation with mixed venous oxygen saturation (SvO2 ) upon changes in systemic oxygenation in extubated cardiac surgical patients. Additionally, we aimed to elucidate whether the ScO2 measurements of both devices can be used interchangeably to detect reduced SvO2 . METHODS: Forty-eight spontaneously breathing patients extubated after cardiac surgery were included in this prospective observational study...
February 26, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29451844/pulmonary-delivery-of-therapeutic-and-diagnostic-gases
#10
Warren M Zapol, H Cecil Charles, Andrew R Martin, Rui C Sá, Binglan Yu, Fumito Ichinose, Neil MacIntyre, Joseph Mammarappallil, Richard Moon, John Z Chen, Eric T Geier, Chantal Darquenne, G Kim Prisk, Ira Katz
The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseous drugs in many cases targets the same therapeutic areas as aerosol drug delivery, and is in many scientific and technical aspects similar to aerosol drug delivery. This article serves as a report on the recent ISAM congress session providing a synopsis of each of the presentations...
April 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29450594/position-paper-for-the-organization-of-ecmo-programs-for-cardiac-failure-in-adults
#11
Darryl Abrams, A Reshad Garan, Akram Abdelbary, Matthew Bacchetta, Robert H Bartlett, James Beck, Jan Belohlavek, Yih-Sharng Chen, Eddy Fan, Niall D Ferguson, Jo-Anne Fowles, John Fraser, Michelle Gong, Ibrahim F Hassan, Carol Hodgson, Xiaotong Hou, Katarzyna Hryniewicz, Shingo Ichiba, William A Jakobleff, Roberto Lorusso, Graeme MacLaren, Shay McGuinness, Thomas Mueller, Pauline K Park, Giles Peek, Vin Pellegrino, Susanna Price, Erika B Rosenzweig, Tetsuya Sakamoto, Leonardo Salazar, Matthieu Schmidt, Arthur S Slutsky, Christian Spaulding, Hiroo Takayama, Koji Takeda, Alain Vuylsteke, Alain Combes, Daniel Brodie
Extracorporeal membrane oxygenation (ECMO) has been used increasingly for both respiratory and cardiac failure in adult patients. Indications for ECMO use in cardiac failure include severe refractory cardiogenic shock, refractory ventricular arrhythmia, active cardiopulmonary resuscitation for cardiac arrest, and acute or decompensated right heart failure. Evidence is emerging to guide the use of this therapy for some of these indications, but there remains a need for additional evidence to guide best practices...
February 15, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29369068/applications-of-near-infrared-spectroscopy-in-the-neonate
#12
Aisling A Garvey, Eugene M Dempsey
PURPOSE OF REVIEW: There has been a significant increase in the utilization of NIRS in neonatal care over the last few years, with some centers now routinely utilizing this monitoring technique for direct intervention at the bedside. In this review, we provide a summary of the most up-to-date evidence on near infrared spectroscopy utilization, with particular emphasis on measurement of cerebral oxygenation in preterm infants. RECENT FINDINGS: There have been significant advances in the technology, leading to an increase in the number of available devices and in the use of this monitoring tool to reduce cerebral injury in preterm infants...
April 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29356911/simple-method-to-make-a-supersaturated-oxygen-fluid
#13
Yoshihiro Tange, Shigenori Yoshitake, Shingo Takesawa
Intravenous oxygenation has demonstrated significant increase in partial pressure of oxygen (PO2 ) in animal models. A highly dissolved oxygen solution might be able to provide a sufficient level of oxygen delivery to the tissues and organs in patients with hypoxia. However, conventional fluid oxygenation methods have required the use of original devices. If simpler oxygenation of a solution is possible, it will be a useful strategy for application in clinical practice. We simply developed its administration by injection of either air or oxygen gas into conventional saline...
January 22, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29323409/in-vitro-comparison-of-two-neonatal-ecmo-circuits-using-a-roller-or-centrifugal-pump-with-three-different-in-line-hemoconcentrators-for-maintaining-hemodynamic-energy-delivery-to-the-patient
#14
Madison Force, Morgan Moroi, Shigang Wang, David A Palanzo, Allen R Kunselman, Akif Ündar
The objective of this study was to compare three different hemoconcentrators (Hemocor HPH 400, Mini, and Junior) with two different neonatal ECMO circuits using a roller or a centrifugal pump at different pseudo-patient pressures and flow rates in terms of hemodynamic properties. This evidence-based research is necessary to optimize the ECMO circuitry for neonates. The circuits used a 300-mL soft-shell reservoir as a pseudo-patient approximating the blood volume of a 3 kg neonate, two blood pumps, and a Quadrox-iD Pediatric oxygenator with three different in-line hemoconcentrators (Hemocor HPH 400, Mini, and Junior)...
January 11, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29314741/a-bench-study-of-inhaled-nitric-oxide-delivery-during-high-frequency-percussive-ventilation
#15
Richard D Branson, Jeff Griebel, Dario Rodriquez
BACKGROUND: Safe and effective delivery of inhaled nitric oxide (INO) requires the appropriate interface of ventilator and INO delivery device. METHODS: We compared INO delivery using four configurations with the Transport Sinusoidal Bronchotron® and INOmax DSIR Plus® in a lung model. Ventilator settings and lung model values were held constant. Delivered NO, NO2 , and inspired oxygen (FIO2 ) were measured. The mean difference between set and measured NO was calculated and compared using ANOVA...
March 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29279366/evaluation-of-safety-and-cost-of-an-open-design-oxygen-mask-in-a-large-community-hospital
#16
Patricia A DeJuilio, Maya B Jenkins, Jeffrey P Huml
BACKGROUND: In our large community hospital, we observed that traditional oxygen masks were sometimes set at an inappropriately low flow. We hoped to eliminate this safety concern through adoption of an open-design oxygen mask. We also hoped that more immediate flow changes would lead to a decrease in medical gas consumption. Finally, by standardizing to one mask, goals were to reduce the cost of oxygen delivery. METHODS: We conducted a retrospective analysis, 12 months before and 12 months after implementation of the open-design oxygen mask...
April 2018: Respiratory Care
https://www.readbyqxmd.com/read/29272974/home-oxygen-therapy-re-thinking-the-role-of-devices
#17
REVIEW
Andrea S Melani, Piersante Sestini, Paola Rottoli
A range of devices are available for delivering and monitoring home oxygen therapy (HOT). Guidelines do not give indications for the choice of the delivery device but recommend the use of an ambulatory system in subjects on HOT whilst walking. Areas covered: We provide a clinical overview of HOT and review traditional and newer delivery and monitoring devices for HOT. Despite relevant technology advancements, clinicians, faced with many challenges when they prescribe oxygen therapy, often remain familiar to traditional devices and continuous flow delivery of oxygen...
March 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29261402/oral-versus-nasal-high-flow-bronchodilator-inhalation-in-chronic-obstructive-pulmonary-disease
#18
Jens Bräunlich, Hubert Wirtz
BACKGROUND: Nasal high flow (NHF) alters breathing patterns, stabilizes fraction of inspired oxygen (FiO2) during respiratory distress, helps to keep up hemostasis in the airways, and washes out the upper airways. Particularly the support of inspiratory flow and decrease in functional dead space are interesting mechanisms of action with regard to aerosol delivery. Several laboratory investigations have studied aerosol delivery via the nasal route by using NHF, whereas clinical benefits are poorly evaluated...
December 20, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29144160/high-flow-nasal-cannula-oxygen-in-adults-an-evidence-based-assessment
#19
Matthew G Drake
High-flow nasal cannula oxygenation has distinct advantages over other oxygen devices because of its unique effects on respiratory physiology. In particular, adjustable oxygen delivery and flow-dependent carbon dioxide clearance reduce work of breathing and better match inspiratory demand during respiratory distress. Historically, few studies had evaluated whether the physiologic effects of these devices translated into clinical benefit. However, recent publications have begun to address this knowledge gap...
February 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29131746/topical-oxygen-therapy-promotes-the-healing-of-chronic-diabetic-foot-ulcers-a-pilot-study
#20
P D Hayes, N Alzuhir, G Curran, I M Loftus
OBJECTIVE: Interventions that can heal or reduce diabetic foot ulcer (DFU) size may reduce the incidence of infection and amputation, and reduce associated social and economic costs. Many chronic wounds exhibit a degree of hypoxia and this leads to a reduction in healing processes including cell division and differentiation, angiogenesis, infection prevention, and collagen production. The aim of this pilot study was to assess the effects of a device supplying continuous oxygen ambulatory therapy on healing in chronic DFUs...
November 2, 2017: Journal of Wound Care
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