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Oxygen delivery devices

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https://www.readbyqxmd.com/read/28599970/cerebral-near-infrared-spectroscopy-insensitively-detects-low-cerebral-venous-oxygen-saturations-after-stage-1-palliation
#1
Erin Rescoe, Xiaoqi Tang, Dorothy Alison Perry, Lynn A Sleeper, James A DiNardo, Barry D Kussman, John N Kheir
BACKGROUND: Measurement of cerebral venous oxyhemoglobin saturation (ScvO2) is considered a gold standard in assessing the adequacy of tissue oxygen delivery (DO2) after the stage 1 palliation (S1P), with SvO2 <30% often representing severely compromised DO2. Regional oxygenation index (rSO2) based on near-infrared resonance spectroscopy (NIRS) frequently is used to screen for compromised DO2, although its sensitivity to detect severe abnormalities in SvO2 is uncertain. METHODS: ScvO2 was measured by co-oximetry from the internal jugular vein as clinically indicated in 73 neonates after S1P...
May 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28555461/high-flow-nasal-cannulae-for-respiratory-support-in-adult-intensive-care-patients
#2
REVIEW
Amanda Corley, Claire M Rickard, Leanne M Aitken, Amy Johnston, Adrian Barnett, John F Fraser, Sharon R Lewis, Andrew F Smith
BACKGROUND: High-flow nasal cannulae (HFNC) deliver high flows of blended humidified air and oxygen via wide-bore nasal cannulae and may be useful in providing respiratory support for adult patients experiencing acute respiratory failure in the intensive care unit (ICU). OBJECTIVES: We evaluated studies that included participants 16 years of age and older who were admitted to the ICU and required treatment with HFNC. We assessed the safety and efficacy of HFNC compared with comparator interventions in terms of treatment failure, mortality, adverse events, duration of respiratory support, hospital and ICU length of stay, respiratory effects, patient-reported outcomes, and costs of treatment...
May 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28546370/pediatric-oxygen-therapy-a-review-and-update
#3
Brian K Walsh, Craig D Smallwood
Oxygen is a colorless, odorless, tasteless gas that is utilized by the body for respiration. Oxygen has played a major role in respiratory care. Oxygen therapy is useful in treating hypoxemia but is often thought of as a benign therapy. After many years of study, we have learned a great deal of the benefits and potential risk of this powerful drug. Today oxygen gas is cheap, widely available, and easy to administer. Oxygen delivery devices vary in cost from a few cents for a simple nasal cannula to $25-$50 for some humidified systems...
June 2017: Respiratory Care
https://www.readbyqxmd.com/read/28488717/endothelial-monolayer-permeability-under-controlled-oxygen-tension
#4
Kenichi Funamoto, Daisuke Yoshino, Kento Matsubara, Ioannis K Zervantonakis, Kiyoe Funamoto, Masafumi Nakayama, Jun Masamune, Yoshitaka Kimura, Roger D Kamm
Endothelial permeability has been extensively investigated in the context of pathologies such as cancer and also in studies of drug delivery from the circulation. Hypoxia is a critical regulator of endothelial cell (EC) behavior and affects the barrier function of endothelial linings, yet its role has been little studied. This paper reveals the effect of hypoxia on the permeability of an EC monolayer by cellular experiments using a microfluidic device and a conventional cell culture dish. Human umbilical vein endothelial cells (HUVECs) were seeded into one microfluidic channel, creating an EC monolayer on each vertical surface of a collagen gel confined to a central chamber...
May 10, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28466203/efficiency-of-oxygen-delivery-through-different-oxygen-entrainment-devices-during-sedation-under-low-oxygen-flow-rate-a-bench-study
#5
Wei-Chih Hsu, Joe Orr, Shih-Pin Lin, Lu Yu, Mei-Yung Tsou, Dwayne R Westenskow, Chien-Kun Ting
Sedative anesthetic procedures outside the operating room may depend on cylinders as oxygen source. Cylinders have limited storage capacity and a low oxygen flow rate improves the durability. We conducted the bench study to evaluate the fraction of inspired oxygen (FiO2) in different oxygen entrainment devices under low oxygen flow rate. The purpose of the bench study was to provide information to choose appropriate oxygen entrainment devices in non-operating room sedative anesthetic procedures. We utilized a manikin head-test lung-ventilator model and evaluated eight oxygen entrainment devices, including four nasal cannulas, two oral bite blocks, and two masks...
May 2, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28448266/a-prospective-randomized-blinded-controlled-trial-comparing-transdermal-continuous-oxygen-delivery-to-moist-wound-therapy-for-the-treatment-of-diabetic-foot-ulcers
#6
Vickie R Driver, Alexander Reyzelman, Jill Kawalec, Michael French
Worldwide, diabetic foot ulcers (DFUs) continue to exact a major burden on patients and health care providers. Although hyperbaric oxygen therapy is well-known as an adjunct option, less is known about the efficacy of transdermal continuous oxygen therapy (TCOT). A prospective, randomized, blinded, multicenter, parallel study was conducted from October 2009 to November 2012 to evaluate healing time and the proportion of DFUs healed after 12 weeks of moist wound therapy (MWT) with or without TCOT. Study participants (persons with type 1 or type 2 diabetes and a nonhealing [>1-month but <1-year duration], 1 cm² to 10 cm² in area, infection-free DFU) were randomized to TCOT or a sham device (control) in addition to receiving MWT...
April 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28433721/optimizing-the-restored-chemotactic-behavior-of-anticancer-agent-salmonella-enterica-serovar-typhimurium-vnp20009
#7
Katherine M Broadway, Seungbeum Suh, Bahareh Behkam, Birgit E Scharf
Bacteria, including strains of Salmonella, have been researched and applied as therapeutic cancer agents for centuries. Salmonella are particularly of interest due to their facultative anaerobic nature, facilitating colonization of differentially oxygenated tumor regions. Additionally, Salmonella can be manipulated with relative ease, resulting in the ability to attenuate the pathogen or engineer vectors for drug delivery. It was recently discovered that the anti-cancer Salmonella enterica serovar Typhimurium strain VNP20009 is lacking in chemotactic ability, due to a non-synonymous single nucleotide polymorphism in cheY...
April 20, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28429120/the-influence-of-pump-rotation-speed-on-hemodynamics-and-myocardial-oxygen-metabolism-in-left-ventricular-assist-device-support-with-aortic-valve-regurgitation
#8
Kei Iizuka, Tomohiro Nishinaka, Yoshiaki Takewa, Kenji Yamazaki, Eisuke Tatsumi
Aortic valve regurgitation (AR) is a serious complication under left ventricular assist device (LVAD) support. AR causes LVAD-left ventricular (LV) recirculation, which makes it difficult to continue LVAD support. However, the hemodynamics and myocardial oxygen metabolism of LVAD support with AR have not been clarified, especially, how pump rotation speed influences them. An animal model of LVAD with AR was newly developed, and how pump rotation speed influences hemodynamics and myocardial oxygen metabolism was examined in acute animal experiments...
April 20, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28393776/serial-semi-invasive-hemodynamic-assessment-following-pericardiectomy-for-chronic-constrictive-pericarditis
#9
Ujjwal Kumar Chowdhury, Poonam Malhotra Kapoor, Adil Rizvi, Vishwas Malik, Sandeep Seth, Rajiv Narang, Mani Kalaivani, Sarvesh Pal Singh, Sathiya Selvam
OBJECTIVES: This study was designed to prospectively investigate the effects of pericardiectomy via median sternotomy on intra- and postoperative hemodynamics by a new semi-invasive device (Flotrac/VigileoTM monitor) using arterial pressure waveform analysis. PATIENTS AND METHODS: Thirty consecutive patients aged 15 to 55 years (mean+SD, 31.73 + 13.53 years), who had undergone total pericardiectomy via median sternotomy underwent serial hemodynamic evaluation. FlotracTM Sensor - derived stroke volume, stroke volume variation, systemic vascular resistance index (SVRI), cardiac index and right atrial pressure were measured just before and after pericardiectomy, at 12 hours, 24 hours, 48 hours, 72 hours and at discharge postoperatively...
April 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28366285/a-review-of-hemodynamic-monitoring-techniques-methods-and-devices-for-the-emergency-physician
#10
Abdullah E Laher, Matthew J Watermeyer, Sean K Buchanan, Nicole Dippenaar, Nelly Clotilde Tchouambou Simo, Feroza Motara, Muhammed Moolla
The emergency department (ED) is frequently the doorway to the intensive care unit (ICU) for a significant number of critically ill patients presenting to the hospital. Hemodynamic monitoring (HDM) which is a key component in the effective management of the critically ill patient presenting to the ED, is primarily concerned with assessing the performance of the cardiovascular system and determining the correct therapeutic intervention to optimise end-organ oxygen delivery. The spectrum of hemodynamic monitoring ranges from simple clinical assessment and routine bedside monitoring to point of care ultrasonography and various invasive monitoring devices...
March 18, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28360433/use-of-near-infrared-spectroscopy-nirs-in-cerebral-tissue-oxygenation-monitoring-in-neonates
#11
Rene Gumulak, Lucia Casnocha Lucanova, Mirko Zibolen
Near-infrared spectroscopy (NIRS) is a technology capable of non-invasive, continuous measuring of regional tissue oxygen saturation (StO2). StO2 represents a state of hemodynamic stability, which is influenced by many factors. Extensive research has been done in the field of measuring StO2 of various organs. The current clinical availability of several NIRS-based devices reflects an important development in prevention, detection and correction of discrepancy in oxygen delivery to the brain and vital organs...
March 30, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28286846/familiarity-of-physicians-and-nurses-with-different-aspects-of-oxygen-therapy-a-brief-report
#12
Reza Goharani, MirMohammad Miri, Mehran Kouchek, Mohammad Sistanizad
INTRODUCTION: Oxygen is a drug and physician and nurses should be familiar with the effects and potential risks of oxygen therapy. The current study aimed to assess familiarity of physicians and nurses with various aspects of oxygen therapy. METHOD: In this cross sectional study, the familiarity of physicians and nurses with various aspects of oxygen therapy in a teaching hospital was evaluated using a validated questionnaire. The collected data were analyzed using SPSS 21 software...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28280719/cerebral-tissue-oxygenation-during-immediate-neonatal-transition-and-resuscitation
#13
REVIEW
Gerhard Pichler, Georg M Schmölzer, Berndt Urlesberger
This article provides a review of cerebral tissue oxygenation during immediate transition after birth in human neonates. Recommended routine monitoring, especially if resuscitation is needed, during this period includes arterial oxygen saturation and heart rate measured by pulse oximetry and electrocardiogram. However, there is increasing interest to monitor in addition with near-infrared spectroscopy (NIRS) the oxygenation of the brain. There is a different pattern of increase between cerebral tissue oxygenation and arterial oxygen saturation during the immediate transition, with cerebral tissue oxygenation reaching a plateau faster than arterial oxygen saturation...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28263248/operating-room-fires-in-oculoplastic-surgery
#14
Robi N Maamari, Philip L Custer
PURPOSE: This study was performed to characterize the frequency, causes, and possible risk factors of operating room (OR) fires experienced by members of the American Society of Ophthalmic Plastic and Reconstructive Surgery. METHODS: An online questionnaire was distributed to American Society of Ophthalmic Plastic and Reconstructive Surgery members, collecting data on surgical fires experienced by respondents throughout their careers. In addition, the questionnaire investigated viewpoints on OR fire safety, current practice patterns with oxygen delivery and surgical device usage, and management of patients referred after previous surgical fire exposure...
March 3, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28263224/acute-ischemia-induced-by-high-density-culture-increases-cytokine-expression-and-diminishes-the-function-and-viability-of-highly-purified-human-islets-of-langerhans
#15
Kate E Smith, Amy C Kelly, Catherine G Min, Craig S Weber, Fiona M McCarthy, Leah V Steyn, Vasudeo Badarinarayana, J Brett Stanton, Jennifer P Kitzmann, Peter Strop, Angelika C Gruessner, Ronald M Lynch, Sean W Limesand, Klearchos K Papas
BACKGROUND: Encapsulation devices have the potential to enable cell based insulin replacement therapies (such as human islet or stem cell derived β cell transplantation) without immunosuppression. However, reasonably sized encapsulation devices promote ischemia due to high β cell densities creating prohibitively large diffusional distances for nutrients. It is hypothesized that even acute ischemic exposure will compromise the therapeutic potential of cell based insulin replacement. In this study, the acute effects of high-density ischemia were investigated in human islets to develop a detailed profile of early ischemia induced changes and targets for intervention...
March 3, 2017: Transplantation
https://www.readbyqxmd.com/read/28219826/hot-topics-in-reactive-oxygen-therapy-antimicrobial-and-immunological-mechanisms-safety-and-clinical-applications
#16
REVIEW
Matthew Dryden, Jonathan Cooke, Rami Salib, Rebecca Holding, Sylvia L F Pender, Jill Brooks
Reactive oxygen species (ROS), when combined with various delivery mechanisms, has the potential to become a powerful novel therapeutic agent against difficult-to-treat infections, especially those involving biofilm. It is important in the context of the global antibiotic resistance crisis. ROS is rapidly active in vitro against all Gram-positive and Gram-negative bacteria tested. ROS also has antifungal and antiviral properties. ROS prevents the formation of biofilms caused by a range of bacterial species in wounds and respiratory epithelium...
February 17, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28213334/reactive-oxygen-a-novel-antimicrobial-mechanism-for-targeting-biofilm-associated-infection
#17
REVIEW
Matthew S Dryden, Jonathan Cooke, Rami J Salib, Rebecca E Holding, Timothy Biggs, Ali A Salamat, Raymond N Allan, Rachel S Newby, Fenella Halstead, Beryl Oppenheim, Thomas Hall, Sophie C Cox, Liam M Grover, Zain Al-Hindi, Lilyann Novak-Frazer, Malcolm D Richardson
Reactive oxygen species (ROS) is a novel therapeutic strategy for topical or local application to wounds, mucosa or internal structures where there may be heavy bacterial bioburden with biofilm and chronic inflammation. Bacterial biofilms are a significant problem in clinical settings owing to their increased tolerance towards conventionally prescribed antibiotics and their propensity for selection of further antibacterial resistance. There is therefore a pressing need for the development of alternative therapeutic strategies that can improve antibiotic efficacy towards biofilms...
February 14, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28176800/plasma-cell-treatment-device-plasma-on-chip-monitoring-plasma-generated-reactive-species-in-microwells
#18
Jun-Seok Oh, Shinya Kojima, Minoru Sasaki, Akimitsu Hatta, Shinya Kumagai
We have developed a plasma cell treatment device called Plasma-on-Chip that enables the real-time monitoring of a single cell culture during plasma treatment. The device consists of three parts: 1) microwells for cell culture, 2) a microplasma device for generating reactive oxygen and nitrogen species (RONS) for use in cell treatment, and 3) through-holes (microchannels) that connect each microwell with the microplasma region for RONS delivery. Here, we analysed the delivery of the RONS to the liquid culture medium stored in the microwells...
February 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28089874/mathematical-modelling-of-cell-layer-growth-in-a-hollow-fibre-bioreactor
#19
Lloyd A C Chapman, Jonathan P Whiteley, Helen M Byrne, Sarah L Waters, Rebecca J Shipley
Generating autologous tissue grafts of a clinically useful volume requires efficient and controlled expansion of cell populations harvested from patients. Hollow fibre bioreactors show promise as cell expansion devices, owing to their potential for scale-up. However, further research is required to establish how to specify appropriate hollow fibre bioreactor operating conditions for expanding different cell types. In this study we develop a simple model for the growth of a cell layer seeded on the outer surface of a single fibre in a perfused hollow fibre bioreactor...
April 7, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28066550/a-microfluidic-based-cell-encapsulation-platform-to-achieve-high-long-term-cell-viability-in-photopolymerized-pegnb-hydrogel-microspheres
#20
Zhongliang Jiang, Bingzhao Xia, Ralph McBride, John Oakey
Cell encapsulation within photopolymerized polyethylene glycol (PEG)-based hydrogel scaffolds has been demonstrated as a robust strategy for cell delivery, tissue engineering, regenerative medicine, and developing in vitro platforms to study cellular behavior and fate. Strategies to achieve spatial and temporal control over PEG hydrogel mechanical properties, chemical functionalization, and cytocompatibility have advanced considerably in recent years. Recent microfluidic technologies have enabled the miniaturization of PEG hydrogels, thus enabling the fabrication of miniaturized cell-laden vehicles...
January 7, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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