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https://www.readbyqxmd.com/read/29391380/protein-enriched-milk-based-supplement-to-counteract-sarcopenia-in-acutely-ill-geriatric-patients-offered-resistance-exercise-training-during-and-after-hospitalisation-study-protocol-for-a-randomised-double-blind-multicentre-trial
#1
Josephine Gade, Anne Marie Beck, Christian Bitz, Britt Christensen, Tobias Wirenfeldt Klausen, Anders Vinther, Arne Astrup
INTRODUCTION: Age-related loss of muscle mass and strength, sarcopaenia, burdens many older adults. The process is accelerated with bed rest, protein intakes below requirements and the catabolic effect of certain illnesses. Thus, acutely ill, hospitalised older adults are particularly vulnerable. Protein supplementation can preserve muscle mass and/or strength and, combining this with resistance exercise training (RT), may have additional benefits. Therefore, this study investigates the effect of protein supplementation as an addition to offering RT among older adults while admitted to the geriatric ward and after discharge...
February 1, 2018: BMJ Open
https://www.readbyqxmd.com/read/29389044/synergistically-active-nico2-s4-nanoparticles-coupled-with-holey-defect-graphene-hydrogel-for-high-performance-solid-state-supercapacitors
#2
Sintayehu Nibret Tiruneh, Bong Kyun Kang, Sung Hoon Kwag, YoungHun Lee, MinSeob Kim, Dae Ho Yoon
Nickel cobalt sulfide nanoparticles embedded in holey defect graphene hydrogel (HGH) that exhibit highly porous structures and uniform nickel cobalt sulfide nanoparticle sizes are successfully prepared by a facile solvothermal-hydrothermal method. As an electrode material for supercapacitors, the as-prepared NiCo2 S4 @HGH shows ultra-high specific capacitances of 1000 F g-1 and 800 F g-1 at 0.5 and 6 A g-1 , respectively, owing to the outstanding electrical conductivity of HGH and high specific capacitance of NiCo2 S4 ...
February 1, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29343946/a-new-pen-device-for-injection-of-recombinant-human-growth-hormone-a-convenience-functionality-and-usability-evaluation-study
#3
Maritta Sauer, Carole Abbotts
Purpose: Adherence to recombinant human growth hormone (r-hGH) is critical to growth and other outcomes in patients with growth disorders, but the requirement for daily injections means that ease of use is an important factor. This study assessed the perceived ease of use and functionality of the prototype of a reusable pen injector (pen device) for r-hGH that incorporates several advanced features. Participants and methods: Semi-structured 60-minute qualitative interviews were conducted in 5 countries with 57 health care professionals (HCPs) and 30 patients with GH deficiency/caregivers administering r-hGH to patients, including children...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29341939/the-quest-for-equivalence-of-test-results-the-pilgrimage-of-the-dutch-calibration-2-000-program-for-metrological-traceability
#4
REVIEW
Rob T P Jansen, Christa M Cobbaert, Cas Weykamp, Marc Thelen
Calibration 2.000 was initiated 20 years ago for standardization and harmonization of medical tests. The program also intended to evaluate adequate implementation of the In Vitro Diagnostics (IVD) 98/79/EC directive, in order to ensure that medical tests are fit-for-clinical purpose. The Calibration 2.000 initiative led to ongoing verification of test standardization and harmonization in the Netherlands using commutable external quality assessment (EQA)-tools and a type 1 EQA-design, where feasible. National support was guaranteed by involving all laboratory professionals as well as laboratory technicians responsible for EQA and quality officers...
January 17, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29299773/a-comparative-epidemiological-study-of-acute-renal-colic-presentations-to-emergency-departments-in-doha-qatar-and-melbourne-australia
#5
Sameer A Pathan, Biswadev Mitra, Zain A Bhutta, Isma Qureshi, Elle Spencer, Asmaa A Hameed, Sana Nadeem, Ramsha Tahir, Shahzad Anjum, Peter A Cameron
BACKGROUND: This study aimed to compare the epidemiology, clinical presentations, management, and outcomes of renal colic presentations in two major academic centers from geographically diverse populations: Qatar (a country in the Afro-Asian stone belt) and South-Eastern Australia (not within a stone belt). METHODS: We undertook a retrospective cohort study of patients with renal colic who presented to the Hamad General Hospital Emergency Department (HGH-ED), Qatar, and The Alfred ED, Melbourne, Australia, during a period of 1 year from August 1, 2012, to July 31, 2013...
January 3, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29283929/the-effect-of-three-different-maximal-concentric-velocity-squat-protocols-on-mapk-phosphorylation-and-endocrine-responses
#6
Rebecca A Kudrna, Andrew C Fry, Justin X Nicoll, Phillip M Gallagher, Michael R Prewitt
The purpose of this study was to determine the effect of three different back squat protocols on intra-cellular signaling, endocrine responses, and power fatigue. Nine recreationally trained males (X±SD; age: 21.4±0.6yrs; height: 177.8±5.1cm; weight: 78.7±9.7kg), completed three maximal concentric velocity squat protocols in a randomized order. Testing protocols consisted of 5 sets of 10 repetitions at 30% of 1RM; 5 sets of 5 repetitions at 70% of 1RM; and 5 sets of 3 repetitions at 90% of 1RM. Average system power for each set was obtained with a tethered external dynamometer...
December 27, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29223399/ectopic-serotonin-production-in-%C3%AE-cell-specific-transgenic-mice
#7
Hyeongseok Kim, Hyunki Kim, Kyuho Kim, Michael S German, Hail Kim
Genetically modified mice have been widely used in the field of β-cell research. However, analysis of results gathered using genetically modified organisms should be interpreted carefully as the results may be confounded by several factors. Here, we showed the ectopic serotonin (5-HT) production in β-cells of RIP-CreMgn, MIP-GFP, and MIP-Cre/ERT. These mice contained a human growth hormone (hGH) cassette to enhance transgene expression and hGH expression and Stat5 phosphorylation were detected in pancreatic islets of these mice...
December 6, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29209767/neuropathology-of-iatrogenic-creutzfeldt-jakob-disease-and-immunoassay-of-french-cadaver-sourced-growth-hormone-batches-suggest-possible-transmission-of-tauopathy-and-long-incubation-periods-for-the-transmission-of-abeta-pathology
#8
Charles Duyckaerts, Véronique Sazdovitch, Kunie Ando, Danielle Seilhean, Nicolas Privat, Zehra Yilmaz, Laurène Peckeu, Elodie Amar, Emmanuel Comoy, Aleksandra Maceski, Sylvain Lehmann, Jean-Pierre Brion, Jean-Philippe Brandel, Stéphane Haïk
Abeta deposits and tau pathology were investigated in 24 French patients that died from iatrogenic Creutzfeldt-Jakob disease after exposure to cadaver-derived human growth hormone (c-hGH) in the 1980s. Abeta deposits were found only in one case that had experienced one of the longest incubation periods. Three cases had also intracellular tau accumulation. The analysis of 24 batches of c-hGH, produced between 1974 and 1988, demonstrated for the first time the presence of Abeta and tau contaminants in c-hGH (in 17 and 6 batches, respectively)...
February 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29200633/effects-of-silver-gymnastic-exercises-on-aging-related-hormones-in-elderly-women-living-alone
#9
Sangsoo Kim, Sungbum Ju
[Purpose] The purpose of this study was to investigate the effect of silver gymnastic exercises on aging-related hormones in elderly women living alone. [Subjects and Methods] The study group consisted of 20 elderly women living alone who performed the silver gymnastic exercises for 12 weeks. Blood samples were obtained for measurement of aging-related hormones (human growth hormone [HGH] and estrogen). [Results] HGH and estrogen levels increased significantly after the exercise program as compared to before the program...
November 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29073481/human-placental-growth-hormone-in-ectopic-pregnancy-detection-in-maternal-blood-immunohistochemistry-and-potential-clinical-implication
#10
Christoph Hübener, Martin Bidlingmaier, Zida Wu, Joachim Diebold, Christian J Strasburger, Sven Mahner, Uwe Hasbargen, Maria Delius
OBJECTIVE: To investigate human placental growth hormone (hGH-V) in ectopic pregnancy (EP): detection in maternal blood, correlation with immunohistochemistry and possible role as a marker for the course of EP. DESIGN: Women presenting in the outpatient or emergency department of a tertiary care university hospital with a positive pregnancy test and strong suspicion of EP by ultrasound and/or symptoms were eligible for the study (n=70). Tissue specimens from the surgically treated patients (n=50) were examined by histopathology as well as by a hGH-V specific immohistochemistry set-up...
October 14, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29038330/can-growth-hormone-treatment-improve-growth-in-children-with-severe-growth-failure-due-to-anorexia-nervosa-a-preliminary-pilot-study
#11
Juliane Léger, Anne Fjellestad-Paulsen, Anne Bargiacchi, Catherine Doyen, Emmanuel Ecosse, Jean-Claude Carel, Marie-France Le Heuzey
BACKGROUND/AIMS: Growth failure is a difficult but key aspect of care in children with anorexia nervosa (AN). The effects of hGH therapy have not been studied. The aim was to investigate the effect of hGH treatment on height velocity (HV) in children with AN. METHODS: We carried out a retrospective observational study. Ten girls diagnosed with AN at 10.0 ± 1.9 years, with prolonged severe growth failure (HV < 2.5 cm/year for at least 18 months) at the age of 13...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28936199/bone-status-in-a-patient-with-insulin-like-growth-factor-1-receptor-deletion-syndrome-bone-quality-and-structure-evaluation-using-dual-energy-x-ray-absorptiometry-peripheral-quantitative-computed-tomography-and-quantitative-ultrasonography
#12
Paola Pelosi, Elisabetta Lapi, Loredana Cavalli, Alberto Verrotti, Marilena Pantaleo, Maurizio de Martino, Stefano Stagi
Haploinsufficiency of the insulin-like growth factor (IGF)-1 receptor (IGF1R) gene is a rare, probably under-diagnosed, cause of short stature. However, the effects of IGF1R haploinsufficiency on glucose metabolism, bone status, and metabolism have rarely been investigated. We report the case of a patient referred to our center at the age of 18 months for short stature, failure to thrive, and Silver-Russell-like phenotype. Genetic analysis did not show hypomethylation of the 11p15.5 region or uniparental disomy of chromosome 7...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28926879/-systematic-evaluation-on-effectiveness-and-safety-of-recombinant-human-growth-hormone-in-treating-adult-patients-with-severe-burn
#13
F Y Tian, B Wu, T Xu, X H Jiang
Objective: To systcmatically evaluate the effectiveness and safety of recombinant human growth hormone (rhGH) in treating adults with severe burn. Methods: Databases including PubMed, Cochrane Library, and Embase were searched using key words " burns, thermal, human growth hormone, growth hormone, hGH, and somatropin (human)" , and China Biology Medicine disc, Chinese Journals Full-text Database, VIP Database, and Wanfang Database were searched using key words in Chinese version "," to obtain the randomized controlled trials about rhGH in the treatment of adults with severe burn from the establishment of each database to December 2016...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28924868/photodegradation-pathways-of-protein-disulfides-human-growth-hormone
#14
Daniel Steinmann, Olivier Mozziconacci, Rupesh Bommana, John F Stobaugh, Y John Wang, Christian Schöneich
PURPOSE: Comprehensive product characterization was performed for the photodegradation of protein disulfides, representatively of human growth hormone (somatotropin; hGH), in order to provide a product database, which will be useful for the general analysis of protein stability. METHODS: HGH was photo-irradiated at λ = 254 and λ > 295 nm and tryptic digests were analyzed by HPLC-MS to investigate light-induced disulfide degradation pathways. RESULTS: A total of 60 products were detected, and structures/tentative structures were assigned to the products by MS(2) and MS(3) analysis...
September 18, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28915901/possible-effects-of-an-early-diagnosis-and-treatment-in-patients-with-growth-hormone-deficiency-the-state-of-art
#15
REVIEW
Stefano Stagi, Perla Scalini, Giovanni Farello, Alberto Verrotti
Growth hormone deficiency (GHD) is a relatively uncommon and heterogeneous endocrine disorder presenting in childhood with short stature. However, during the neonatal period, the metabolic effects of GHD may to require prompt replacement therapy to avoid possible life-threatening complications. An increasing amount of data suggests the importance of an early diagnosis and treatment of GHD because of its auxological, metabolic, and neurodevelopmental features with respect to the patients diagnosed and treated later in life...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28851205/designing-signal-peptides-for-efficient-periplasmic-expression-of-human-growth-hormone-in-escherichia-coli
#16
Meisam Jeiranikhameneh, Farzaneh Moshiri, Soheil Keyhan Falasafi, Alireza Zomorodipour
The secretion efficiency of a protein in a Sec-type secretion system is mainly determined by an N-terminal signal peptide and its combination with its cognate protein. Five signal peptides, namely, two synthetic Sec-type and three Bacillus licheniformis alpha-amylase-derived signal peptides, were compared for periplasmic expression of the human growth hormone (hGH) in E. coli. Based on in silico predictions on the signal peptides' cleavage efficiencies and their corresponding mRNA secondary structures, a number of amino acid substitutions and silent mutations were considered in the modified signal sequences...
November 28, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28842980/escherichia-coli-tatexpress-strains-super-secrete-human-growth-hormone-into-the-bacterial-periplasm-by-the-tat-pathway
#17
Douglas F Browning, Kirsty L Richards, Amber R Peswani, Jo Roobol, Stephen J W Busby, Colin Robinson
Numerous high-value proteins are secreted into the Escherichia coli periplasm by the General Secretory (Sec) pathway, but Sec-based production chassis cannot handle many potential target proteins. The Tat pathway offers a promising alternative because it transports fully folded proteins; however, yields have been too low for commercial use. To facilitate Tat export, we have engineered the TatExpress series of super-secreting strains by introducing the strong inducible bacterial promoter, ptac, upstream of the chromosomal tatABCD operon, to drive its expression in E...
December 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28748655/high-throughput-automated-microbial-bioreactor-system-used-for-clone-selection-and-rapid-scale-down-process-optimisation
#18
M Lourdes Velez-Suberbie, John Pj Betts, Kelly L Walker, Colin Robinson, Barney Zoro, Eli Keshavarz-Moore
High throughput automated fermentation systems have become a useful tool in early bioprocess development. In this study, we investigated a 24 x 15 mL single use microbioreactor system, ambr 15f, designed for microbial culture. We compared the fed-batch growth and production capabilities of this system for two Escherichia coli strains, BL21 (DE3) and MC4100, and two industrially relevant molecules, hGH and scFv. In addition, different carbon sources were tested using bolus, linear or exponential feeding strategies, showing the capacity of the ambr 15f system to handle automated feeding...
July 27, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28748371/acute-effects-of-heated-resistance-exercise-in-female-and-male-power-athletes
#19
Julia R Casadio, Adam G Storey, Fabrice Merien, Andrew E Kilding, James D Cotter, Paul B Laursen
PURPOSE: To determine the effects of heated resistance exercise on thermal strain, neuromuscular function and hormonal responses in power athletes. METHODS: Sixteen (n = 8 female; 8 male) highly trained power athletes completed a combined strength and power resistance exercise session in hot (HOT ~30 °C) and temperate (CON ~20 °C) conditions. Human growth hormone (hGH), cortisol and testosterone concentrations in plasma, peak power (counter-movement jump, CMJ) and peak force (isometric mid-thigh pull) were measured before and after each training session; thermoregulatory responses were monitored during training...
October 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28730965/efficient-non-invasive-plasmid-dna-administration-into-tibialis-cranialis-muscle-of-little-mice
#20
C R Cecchi, E Higuti, E R Lima, D P Vieira, P L Squair, C N Peroni, P Bartolini
BACKGROUND: An alternative treatment for growth hormone deficiency based on hGH-DNA administration, followed by electro gene transfer, was investigated by injecting the plasmid into surgically exposed or non-exposed quadriceps or tibialis muscle of immunodeficient "little" mice. METHODS: An optimization of electrotransfer conditions via a new combination of high/low voltage pulses is presented. After 3 days, serum hGH was determined and in a 28-day assay, the relative growth parameters were compared...
2017: Current Molecular Medicine
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