keyword
MENU ▼
Read by QxMD icon Read
search

hGH

keyword
https://www.readbyqxmd.com/read/29921469/transgenic-artifacts-caused-by-passenger-human-growth-hormone
#1
Geoffroy de Faudeur, Bas Brouwers, Frans Schuit, John W M Creemers, Bruno Ramos-Molina
The minigene encoding human growth hormone (hGH) has been incorporated into over 300 transgenic mouse lines to improve transgene expression. However, unexpected and functional hGH expression can drastically alter physiology. We list here the mouse lines in which ectopic hGH has been confirmed, and we provide a wiki for lines awaiting analysis.
June 16, 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29908748/mercury-levels-in-human-population-from-a-mining-district-in-western-colombia
#2
Harry Gutiérrez-Mosquera, S B Sujitha, M P Jonathan, S K Sarkar, Fairy Medina-Mosquera, Helcias Ayala-Mosquera, Gladis Morales-Mira, Laura Arreola-Mendoza
A biomonitoring study was carried out to examine the adverse impacts of total mercury in the blood (HgB), urine (HgU) and human scalp hair (HgH) on the residents of a mining district in Colombia. Representative biological samples (scalp hair, urine and blood) were collected from volunteered participants (n=63) to estimate the exposure levels of THg using a Direct mercury analyzer. The geometric mean of THg concentrations in the hair, urine and blood of males were 15.98μg/g, 23.89μg/L and 11.29μg/L respectively, whereas the females presented values of 8...
June 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29763375/chromosomal-architecture-and-placental-expression-of-the-human-growth-hormone-gene-family-are-targeted-by-pre-pregnancy-maternal-obesity
#3
Yan Jin, Hana Vakili, SongYan Liu, Savas Menticoglou, Margaret E Bock, Peter A Cattini
The human (h) placental lactogenic hormone chorionic somatomammotropin (CS) is highly produced during pregnancy and acts as a metabolic adaptor in response to maternal insulin resistance. Maternal obesity can exacerbate this "resistance" and a >75% decrease in CS RNA levels was observed in term placentas from obese versus lean women. The genes coding for hCS (hCS-A and hCS-B) and placental growth hormone (hGH-V) as well as the hCS-L pseudogene and pituitary growth hormone (GH) gene (hGH-N) are located at a single locus on chromosome 17...
May 15, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29736949/evaluation-of-the-clinical-application-of-multiple-tumor-marker-protein-chip-in-the-diagnostic-of-lung-cancer
#4
Xiaochuan Wang, Yi Zhang, Liangqi Sun, Shuaiping Wang, Jing Nie, Wenqing Zhao, Guobao Zheng
BACKGROUND: The early diagnostic of lung cancer plays an important role in the prognosis of surgical treatment among lung cancer patients. To evaluate the clinical application of multi-tumor markers protein biochip in the diagnosis of lung cancer, 12 tumor markers were detected in patients with different stages of lung cancer. METHODS: Serum CA125, CA19-9, Ferritin, CA15-3, CA242, CEA, AFP, NSE, PSA, f-PSA, HGH, and β-HGH were assessed in 506 patients, with 224 patients with lung cancer (including 123 cases of adenocarcinoma, 30 squamous cell carcinoma, 54 small-cell carcinoma, and 17 non classification), 159 patients with benign lung disease and 90 healthy people control by the C-12 multiple tumor protein-chip detective system...
May 7, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29700627/the-preservation-of-lyophilized-human-growth-hormone-activity-how-do-buffers-and-sugars-interact
#5
Andrea Arsiccio, Roberto Pisano
PURPOSE: One of the most common classes of excipients used in protein formulations are buffers. The aim of this work is to investigate the effect of buffers on protein stabilization given by sugars during freeze drying. METHODS: Molecular Dynamics simulations of human growth hormone (hGH) in the presence of sucrose and trehalose were performed, and the impact of phosphate and citrate buffers on their protective action was analyzed. RESULTS: We found that buffers broke the hydrogen bonding network formed by excipients, and the consequences of this disruption of structure ordering were different in sucrose-based or trehalose-based formulations...
April 26, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29679482/an-impurity-characterization-based-approach-for-the-rapid-development-of-integrated-downstream-purification-processes
#6
Steven M Timmick, Nicholas Vecchiarello, Chaz Goodwine, Laura E Crowell, Kerry R Love, J Christopher Love, Steven M Cramer
In this study, we describe a new approach for the characterization of process-related impurities along with an in silico tool to generate orthogonal, integrated downstream purification processes for biological products. A one-time characterization of process-related impurities from product expression in Pichia pastoris was first carried out using linear salt and pH gradients on a library of multimodal, salt-tolerant, and hydrophobic charge induction chromatographic resins. The Reversed-phase ultra-performance liquid chromatography (UPLC) analysis of the fractions from these gradients was then used to generate large data sets of impurity profiles...
April 21, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29653178/surfactants-as-stabilizers-for-biopharmaceuticals-an-insight-into-the-molecular-mechanisms-for-inhibition-of-protein-aggregation
#7
Andrea Arsiccio, Roberto Pisano
PURPOSE: Surfactants are common stabilizers, often added to biopharmaceuticals formulations, but the mechanisms at the basis of their activity are unclear. The aim of this work is to provide insight into the molecular factors underlying surfactant effectiveness as protectants. METHODS: Molecular Dynamics simulations of human growth hormone (hGH) in the presence of Tween 20 were performed. The effect of Tween 20 was compared with the activity of commonly used protectants, such as the disaccharides...
July 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29609574/utility-of-serum-igf-1-for-diagnosis-of-growth-hormone-deficiency-following-traumatic-brain-injury-and-sport-related-concussion
#8
Kirstie Lithgow, Alex Chin, Chantel T Debert, Gregory A Kline
BACKGROUND: Growth hormone deficiency (GHD) is a potential consequence of traumatic brain injury (TBI), including sport-related concussion (SRC). GH stimulation testing is required for definitive diagnosis; however, this is resource intensive and can be associated with adverse symptoms or risks. Measurement of serum IGF-1 is more practical and accessible, and pituitary tumour patients with hypopituitarism and low serum IGF-1 have been shown to have a high probability of GHD. We aimed to evaluate IGF-1 measurement for diagnosing GHD in our local TBI population...
April 2, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29546461/structural-stability-of-recombinant-human-growth-hormone-r-hgh-as-a-function-of-polymer-surface-properties
#9
Vaishnavi Rohitkumar Shah, Pardeep K Gupta
PURPOSE: Despite the fact that r-hGH was first approved for use by FDA in 1995 and the conventional dosage form in the market has a limitation of daily subcutaneous injections, there remains a lack of sustained delivery system in the market. Nutropin depot, a long-acting dosage form of r-hGH was approved for marketing by FDA in 1999, however, it was discontinued in 2004. Since then, unabating efforts have been made to develop biodegradable polymer based formulations for r-hGH delivery...
March 15, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29537382/a-novel-variant-c-97c-t-of-the-growth-hormone-releasing-hormone-receptor-gene-causes-isolated-growth-hormone-deficiency-type-ib
#10
Assimina Galli-Tsinopoulou, Eleni P Kotanidou, Aggeliki N Kleisarchaki, Rivka Kauli, Zvi Laron
Congenital Isolated growth hormone deficiency (IGHD) type Ib is an autosomal recessive genetic condition caused by mutations of GH1 or the GH releasing hormone receptor (GHRH-R) gene. Affected subjects present symptoms of GHD with low but detectable levels of GH, short stature and responsiveness to GH therapy. We describe a 13-month old girl with severe growth failure who showed a low hGH in response to 2 hGH provocative tests and a modest increase of IGF-I to an IGF-I generation test. Whole exome sequencing revealed a novel homozygous variant of the GHRH-R gene (c...
February 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29529228/live-longer-better-the-historical-roots-of-human-growth-hormone-as-anti-aging-medicine
#11
Aimee Medeiros, Elizabeth Siegel Watkins
In recent years, historians have turned their attention to the emergence of anti-aging medicine, suggesting that this interest group coalesced in the wake of widespread availability of recombinant human growth hormone (HGH) after 1985. We take a longer view of modern anti-aging medicine, unearthing a nexus of scientific, medical, and cultural factors that developed over several decades in the twentieth century to produce circumstances conducive to the emergence of this medical sub-specialty established on the premise of the anti-aging effects of HGH...
February 24, 2018: Journal of the History of Medicine and Allied Sciences
https://www.readbyqxmd.com/read/29525202/a-comparison-of-the-acute-physiological-responses-to-bodypump%C3%A2-versus-iso-caloric-and-iso-time-steady-state-cycling
#12
Nigel Harris, Andrew Kilding, Shivani Sethi, Fabrice Merien, Jinger Gottschall
OBJECTIVES: Given apparent consumer interest in calorie counting and arguably inadequate understanding of the differential effects of exercise modality despite equivalent caloric expenditure, we sought to quantify and compare the acute physiological responses within and between a BODYPUMP™ (BP) group-fitness class and steady-state cycling (CARDIO), matched for caloric cost (iso-caloric) and time (iso-time). DESIGN: Acute cross-over study design. METHODS: Twelve healthy recreationally active females (30...
March 2, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29515055/prevalence-of-diverse-complications-and-its-association-with-karyotypes-in-japanese-adult-women-with-turner-syndrome-a-questionnaire-survey-by-the-foundation-for-growth-science
#13
Kunihiko Hanew, Toshiaki Tanaka, Reiko Horikawa, Tomonobu Hasegawa, Susumu Yokoya
The reported prevalence of complications in Turner Syndrome (TS) was highly variable because of the rarity and the limited numbers analyzed. Again, possible presence of other complications that are not described as specific for TS, is also speculated. To resolve these issues, a questionnaire survey was conducted in hGH treated 492 patients with adult TS (17-42 years). The possible association with these complications and karyotypes were also analyzed. The complications and their prevalence were as follows: chronic thyroiditis (25...
March 7, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29488103/multi-centre-phase-iv-trial-to-investigate-the-immunogenicity-of-a-new-liquid-formulation-of-recombinant-human-growth-hormone-in-adults-with-growth-hormone-deficiency
#14
G Johannsson, K Nespithal, U Plöckinger, V Alam, M McLean
PURPOSE: To investigate whether a new liquid formulation of recombinant human growth hormone (r-hGH) induces the production of binding antibodies (BAbs) in adults with congenital or adult-onset growth hormone deficiency (GHD). METHODS: Men or women aged 19-65 years with adult growth hormone deficiency who were r-hGH-naïve or had stopped treatment ≥ 1 month before screening were treated with between 0.15 and 0.30 mg/day r-hGH liquid formulation for 39 weeks...
February 27, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29391380/protein-enriched-milk-based-supplement-to-counteract-sarcopenia-in-acutely-ill-geriatric-patients-offered-resistance-exercise-training-during-and-after-hospitalisation-study-protocol-for-a-randomised-double-blind-multicentre-trial
#15
Josephine Gade, Anne Marie Beck, Christian Bitz, Britt Christensen, Tobias Wirenfeldt Klausen, Anders Vinther, Arne Astrup
INTRODUCTION: Age-related loss of muscle mass and strength, sarcopaenia, burdens many older adults. The process is accelerated with bed rest, protein intakes below requirements and the catabolic effect of certain illnesses. Thus, acutely ill, hospitalised older adults are particularly vulnerable. Protein supplementation can preserve muscle mass and/or strength and, combining this with resistance exercise training (RT), may have additional benefits. Therefore, this study investigates the effect of protein supplementation as an addition to offering RT among older adults while admitted to the geriatric ward and after discharge...
February 1, 2018: BMJ Open
https://www.readbyqxmd.com/read/29389044/synergistically-active-nico-2-s-4-nanoparticles-coupled-with-holey-defect-graphene-hydrogel-for-high-performance-solid-state-supercapacitors
#16
Sintayehu Nibret Tiruneh, Bong Kyun Kang, Sung Hoon Kwag, YoungHun Lee, MinSeob Kim, Dae Ho Yoon
Nickel cobalt sulfide nanoparticles embedded in holey defect graphene hydrogel (HGH) that exhibit highly porous structures and uniform nickel cobalt sulfide nanoparticle sizes are successfully prepared by a facile solvothermal-hydrothermal method. As an electrode material for supercapacitors, the as-prepared NiCo2 S4 @HGH shows ultra-high specific capacitances of 1000 F g-1 and 800 F g-1 at 0.5 and 6 A g-1 , respectively, owing to the outstanding electrical conductivity of HGH and high specific capacitance of NiCo2 S4 ...
March 2, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29343946/a-new-pen-device-for-injection-of-recombinant-human-growth-hormone-a-convenience-functionality-and-usability-evaluation-study
#17
Maritta Sauer, Carole Abbotts
Purpose: Adherence to recombinant human growth hormone (r-hGH) is critical to growth and other outcomes in patients with growth disorders, but the requirement for daily injections means that ease of use is an important factor. This study assessed the perceived ease of use and functionality of the prototype of a reusable pen injector (pen device) for r-hGH that incorporates several advanced features. Participants and methods: Semi-structured 60-minute qualitative interviews were conducted in 5 countries with 57 health care professionals (HCPs) and 30 patients with GH deficiency/caregivers administering r-hGH to patients, including children...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29341939/the-quest-for-equivalence-of-test-results-the-pilgrimage-of-the-dutch-calibration-2-000-program-for-metrological-traceability
#18
REVIEW
Rob T P Jansen, Christa M Cobbaert, Cas Weykamp, Marc Thelen
Calibration 2.000 was initiated 20 years ago for standardization and harmonization of medical tests. The program also intended to evaluate adequate implementation of the In Vitro Diagnostics (IVD) 98/79/EC directive, in order to ensure that medical tests are fit-for-clinical purpose. The Calibration 2.000 initiative led to ongoing verification of test standardization and harmonization in the Netherlands using commutable external quality assessment (EQA)-tools and a type 1 EQA-design, where feasible. National support was guaranteed by involving all laboratory professionals as well as laboratory technicians responsible for EQA and quality officers...
January 17, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29299773/a-comparative-epidemiological-study-of-acute-renal-colic-presentations-to-emergency-departments-in-doha-qatar-and-melbourne-australia
#19
Sameer A Pathan, Biswadev Mitra, Zain A Bhutta, Isma Qureshi, Elle Spencer, Asmaa A Hameed, Sana Nadeem, Ramsha Tahir, Shahzad Anjum, Peter A Cameron
BACKGROUND: This study aimed to compare the epidemiology, clinical presentations, management, and outcomes of renal colic presentations in two major academic centers from geographically diverse populations: Qatar (a country in the Afro-Asian stone belt) and South-Eastern Australia (not within a stone belt). METHODS: We undertook a retrospective cohort study of patients with renal colic who presented to the Hamad General Hospital Emergency Department (HGH-ED), Qatar, and The Alfred ED, Melbourne, Australia, during a period of 1 year from August 1, 2012, to July 31, 2013...
January 3, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29283929/the-effect-of-three-different-maximal-concentric-velocity-squat-protocols-on-mapk-phosphorylation-and-endocrine-responses
#20
Rebecca A Kudrna, Andrew C Fry, Justin X Nicoll, Phillip M Gallagher, Michael R Prewitt
The purpose of this study was to determine the effect of three different back squat protocols on intra-cellular signaling, endocrine responses, and power fatigue. Nine recreationally trained males (X±SD; age: 21.4±0.6yrs; height: 177.8±5.1cm; weight: 78.7±9.7kg), completed three maximal concentric velocity squat protocols in a randomized order. Testing protocols consisted of 5 sets of 10 repetitions at 30% of 1RM; 5 sets of 5 repetitions at 70% of 1RM; and 5 sets of 3 repetitions at 90% of 1RM. Average system power for each set was obtained with a tethered external dynamometer...
December 27, 2017: Journal of Strength and Conditioning Research
keyword
keyword
1535
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"