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https://www.readbyqxmd.com/read/28922600/ptml-model-for-proteome-mining-of-b-cell-epitopes-and-theoretic-experimental-study-of-bm86-protein-sequences-from-colima-mexico
#1
Saúl Gabriel Martínez, Esvieta Tenorio-Borroto, Alberto Barbabosa Pliego, Hector Diaz-Albiter, Juan C Vazquez-Chagoyan, Humbert Gonzalez-Diaz
In this work, we developed a general Perturbation Theory and Machine Learning (PTML) method for data mining of proteomes, in order to discover new B-cell epitopes useful for vaccine design. The method predicts the epitope activity εq(cqj) of one query peptide (q-peptide) in a set of experimental query conditions (cqj). The method uses as input the sequence of the q-peptide. The method also uses as input information about the sequence and epitope activity εr(crj) of a peptide of reference (r-peptide) assayed on similar experimental conditions (crj)...
September 18, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28922302/resident-knowledge-surgical-skill-and-confidence-in-transobturator-vaginal-tape-placement-the-value-of-a-cadaver-laboratory
#2
Woojin Chong, Keith Downing, Ava Leegant, Erika Banks, Dmitry Fridman, Sherry Downie
OBJECTIVES: The objective of this study is to examine the effect of additional cadaver laboratory use in training obstetrics and gynecology (OBGYN) residents on transobturator vaginal tape (TOT) insertion. METHODS: Thirty-four OBGYN residents were randomized into 2 groups (group 1, control; group 2, intervention; 17 in each group). Before and after the interventions, written knowledge and confidence levels were assessed. Both groups received didactic lectures using a bony pelvis and an instructional video on TOT insertion; group 2 participated in a half day cadaver laboratory...
September 15, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28922158/tailored-and-adaptive-computerized-cognitive-training-in-older-adults-at-risk-for-dementia-a-randomized-controlled-trial
#3
Alex Bahar-Fuchs, Shannon Webb, Lauren Bartsch, Linda Clare, George Rebok, Nicolas Cherbuin, Kaarin J Anstey
BACKGROUND: Computerized Cognitive Training (CCT) has been shown to improve cognitive function in older adults with mild cognitive impairment (MCI) or mood-related neuropsychiatric symptoms (MrNPS), but many questions remain unresolved. OBJECTIVE: To evaluate the extent to which CCT benefits older adults with both MCI and MrNPS, and its effects on meta-cognitive and non-cognitive outcomes, as well as establish whether adapting difficulty levels and tailoring to individuals' profile is superior to generic training...
September 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28922123/a-data-driven-approach-for-furniture-and-indoor-scene-colorization
#4
Jie Zhu, Yanwen Guo, Han Ma
We present a data-driven approach that colorizes 3D furniture models and indoor scenes by leveraging indoor images on the internet. Our approach is able to colorize the furniture automatically according to an example image. The core is to learn image-guided mesh segmentation to segment the model into different parts according to the imaged object. Given an indoor scene, the system supports colorization-by-example, and has the ability to recommend the colorization scheme that is consistent with a user-desired color theme...
September 18, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28922116/iterative-low-dose-ct-reconstruction-with-priors-trained-by-artificial-neural-network
#5
Dufan Wu, Kyungsang Kim, Georges El Fakhri, Quanzheng Li
Dose reduction in computed tomography (CT) is essential for decreasing radiation risk in clinical applications. Iterative reconstruction algorithms are one of the most promising way to compensate for the increased noise due to reduction of photon flux. Most iterative reconstruction algorithms incorporate manually designed prior functions of the reconstructed image to suppress noises while maintaining structures of the image. These priors basically rely on smoothness constraints and cannot exploit more complex features of the image...
September 15, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28922051/effect-of-hospital-simulation-tutorials-on-nursing-and-pharmacy-student-perception-of-interprofessional-collaboration-findings-from-a-pilot-study
#6
Paulina Stehlik, Astrid Frotjold, Carl R Schneider
Interprofessional learning (IPL) during formal training enables interprofessional collaboration (IPC) in the workforce; however, on-campus IPL opportunities are seldom incorporated into curricula. We describe the development and implementation of two hospital simulation tutorials between nursing and pharmacy students. Students were required to provide "usual care" to a simulated patient at admission and discharge. A pre-post survey design was used to evaluate changes in Interdisciplinary Education Perception Scale (IEPS) score and student perceived educational value of the tutorials...
September 18, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28922022/implementing-a-collaborative-coaching-intervention-for-professionals-providing-care-to-children-and-their-families-an-exploratory-study
#7
Sandy K Tatla, Dori Howard, Alda Antunes Silvestre, Stacey Burnes, Meghan Husson, Tal Jarus
The growing complexity of healthcare requires family and interprofessional partnerships to deliver effective care. Interprofessional coaching can enhance family-centred practice and collaboration. The purpose of this study was to explore the acceptability and feasibility of collaborative coaching training to improve family centredness within acute paediatric rehabilitation. Using a participatory action design, service providers (SPs; n = 36) underwent a 6-month coaching programme involving coaching workshops, learning triads, and tailored sessions with a licensed coach...
September 18, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28921845/detection-and-delineation-of-squamous-neoplasia-with-hyperspectral-imaging-in-a-mouse-model-of-tongue-carcinogenesis
#8
Guolan Lu, Dongsheng Wang, Xulei Qin, Susan Muller, Xu Wang, Amy Y Chen, Zhuo Georgia Chen, Baowei Fei
yperspectral imaging (HSI) holds the potential for the noninvasive detection of cancers. Oral cancers are often diagnosed at a late stage when treatment is less effective and the mortality and morbidity rates are high. Early detection of oral cancer is, therefore, crucial in order to improve the clinical outcomes. To investigate the potential of HSI as a non-invasive diagnostic tool, an animal study was designed to acquire hyperspectral images of in vivo and ex vivo mouse tongues from a chemically induced tongue carcinogenesis model...
September 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28921711/foxp-expression-identifies-a-kenyon-cell-subtype-in-the-honeybee-mushroom-bodies-linking-them-to-fruitfly-%C3%AE-%C3%AE-c-neurons
#9
Adriana Schatton, Constance Scharff
The arthropod mushroom bodies (MB) are a higher order sensory integration center. In insects, they play a central role in associative olfactory learning and memory. In Drosophila melanogaster (Dm), the highly ordered connectivity of heterogeneous MB neuron populations has been mapped using sophisticated molecular genetic and anatomical techniques. The MB-core subpopulation was recently shown to express the transcription factor FoxP with relevance for decision-making. Here we report the development and adult distribution of a FoxP-expressing neuron population in the MB of honeybees (Apis mellifera, Am) using in situ hybridization and a custom-made antiserum...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28921541/automatic-labeling-of-mr-brain-images-through-extensible-learning-and-atlas-forests
#10
Lijun Xu, Hong Liu, Enmin Song, Meng Yan, Renchao Jin, Chih-Cheng Hung
PURPOSE: Multi-atlas-based method is extensively used in MR brain images segmentation because of its simplicity and robustness. This method provides excellent accuracy while time-consuming and limited in terms of obtaining information about new atlases. In this study, an automatic labeling of MR brain images through extensible learning and atlas forest is presented to address these limitations. METHODS: We propose an extensible learning model which allows the multi-atlas-based framework capable of managing the datasets with numerous atlases or dynamic atlas datasets and simultaneously ensure the accuracy of automatic labeling...
September 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28920909/credit-card-fraud-detection-a-realistic-modeling-and-a-novel-learning-strategy
#11
Andrea Dal Pozzolo, Giacomo Boracchi, Olivier Caelen, Cesare Alippi, Gianluca Bontempi
Detecting frauds in credit card transactions is perhaps one of the best testbeds for computational intelligence algorithms. In fact, this problem involves a number of relevant challenges, namely: concept drift (customers' habits evolve and fraudsters change their strategies over time), class imbalance (genuine transactions far outnumber frauds), and verification latency (only a small set of transactions are timely checked by investigators). However, the vast majority of learning algorithms that have been proposed for fraud detection rely on assumptions that hardly hold in a real-world fraud-detection system (FDS)...
September 14, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28920505/learning-to-use-a-rear-mounted-power-assist-for-manual-wheelchairs
#12
Bonita Sawatzky, W Ben Mortenson, Stephanie Wong
OBJECTIVES: 1) To investigate how much training manual wheelchair users perceive is required to learn to use a rear-mounted power assist safely and confidently. 2) To evaluate how the power assist affected wheelchair users' ability to negotiate a standardized obstacle course, wheelchair skills capacity and wheelchair mobility confidence. METHOD: This study used a pre- versus post-test intervention design. Outcome measures included a standardized obstacle course, and modified versions of the Wheelchair Skills Test 4...
September 18, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/28920069/assessment-of-thermal-pain-sensation-in-rats-and-mice-using-the-hargreaves-test
#13
Menghon Cheah, James W Fawcett, Melissa R Andrews
The Hargreaves test is specifically designed to assess thermal pain sensation in rodents such as rats and mice. This test has been used in experiments involving pain sensitization or recovery of thermal pain response following neural injury and regeneration. We present here a step-by-step protocol highlighted with important notes to guide first-time users through the learning process. Additionally, we have also included representative data from a rat model of sensory denervation showing how the data can be analysed to obtain meaningful results...
August 20, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28919839/ground-up-top-down-a-mixed-method-action-research-study-aimed-at-normalising-research-in-practice-for-nurses-and-midwives
#14
Vicki Parker, Gena Lieschke, Michelle Giles
BACKGROUND: Improving health, patient and system outcomes through a practice-based research agenda requires infrastructural supports, leadership and capacity building approaches, at both the individual and organisational levels. Embedding research as normal nursing and midwifery practice requires a flexible approach that is responsive to the diverse clinical contexts within which care is delivered and the variable research skills and interest of clinicians. This paper reports the study protocol for research being undertaken in a Local Health District (LHD) in New South Wales (NSW) Australia...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28917648/challenges-of-conducting-a-prospective-clinical-trial-for-older-patients-lessons-learned-from-ncctg-n0949-alliance
#15
Nadine J McCleary, Joleen Hubbard, Michelle R Mahoney, Jeffrey A Meyerhardt, Daniel Sargent, Alan Venook, Axel Grothey
OBJECTIVES: While the risk of developing colorectal cancer increases with age, there are limited prospective data regarding best treatment in the older adult population. We launched a phase III trial to evaluate difference in treatment outcome for older adults (aged ≥70years) with advanced colorectal cancer. Here we review the challenges faced and reasons for poor accrual to N0949. MATERIALS AND METHODS: We describe the conceptualization, development and limited results of N0949, a randomized phase III study of fluoropyrimidine/bevacizumab with or without oxaliplatin (mFOLFOX7 or XELOX) as first line chemotherapy for metastatic colorectal cancer...
September 13, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28917135/failing-to-learn-from-negative-prediction-errors-obesity-is-associated-with-alterations-in-a-fundamental-neural-learning-mechanism
#16
David Mathar, Jane Neumann, Arno Villringer, Annette Horstmann
Prediction errors (PEs) encode the difference between expected and actual action outcomes in the brain via dopaminergic modulation. Integration of these learning signals ensures efficient behavioral adaptation. Obesity has recently been linked to altered dopaminergic fronto-striatal circuits, thus implying impairments in cognitive domains that rely on its integrity. 28 obese and 30 lean human participants performed an implicit stimulus-response learning paradigm inside an fMRI scanner. Computational modeling and psycho-physiological interaction (PPI) analysis was utilized for assessing PE-related learning and associated functional connectivity...
August 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28916581/optimising-impact-and-sustainability-a-qualitative-process-evaluation-of-a-complex-intervention-targeted-at-compassionate-care
#17
Jackie Bridges, Carl May, Alison Fuller, Peter Griffiths, Wendy Wigley, Lisa Gould, Hannah Barker, Paula Libberton
BACKGROUND: Despite concerns about the degree of compassion in contemporary healthcare, there is a dearth of evidence for health service managers about how to promote compassionate healthcare. This paper reports on the implementation of the Creating Learning Environments for Compassionate Care (CLECC) intervention by four hospital ward nursing teams. CLECC is a workplace educational intervention focused on developing sustainable leadership and work-team practices designed to support team relational capacity and compassionate care delivery...
September 15, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28914787/a-sparse-dictionary-learning-based-adaptive-patch-inpainting-method-for-thick-clouds-removal-from-high-spatial-resolution-remote-sensing-imagery
#18
Fan Meng, Xiaomei Yang, Chenghu Zhou, Zhi Li
Cloud cover is inevitable in optical remote sensing (RS) imagery on account of the influence of observation conditions, which limits the availability of RS data. Therefore, it is of great significance to be able to reconstruct the cloud-contaminated ground information. This paper presents a sparse dictionary learning-based image inpainting method for adaptively recovering the missing information corrupted by thick clouds patch-by-patch. A feature dictionary was learned from exemplars in the cloud-free regions, which was later utilized to infer the missing patches via sparse representation...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28914160/making-boundaries-great-again-essentialism-and-support-for-boundary-enhancing-initiatives
#19
Steven O Roberts, Arnold K Ho, Marjorie Rhodes, Susan A Gelman
Psychological essentialism entails a focus on category boundaries (e.g., categorizing people as men or women) and an increase in the conceptual distance between those boundaries (e.g., accentuating the differences between men and women). Across eight studies, we demonstrate that essentialism additionally entails an increase in support for boundary-enhancing legislation, policies, and social services, and that it does so under conditions that disadvantage social groups, as well as conditions that benefit them...
August 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28913703/using-technology-and-assessment-to-personalize-instruction-preventing-reading-problems
#20
Carol McDonald Connor
Children who fail to learn to read proficiently are at serious risk of referral to special education, grade retention, dropping out of high school, and entering the juvenile justice system. Accumulating research suggests that instruction regimes that rely on assessment to inform instruction are effective in improving the implementation of personalized instruction and, in turn, student learning. However, teachers find it difficult to interpret assessment results in a way that optimizes learning opportunities for all of the students in their classrooms...
September 15, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
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