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Wiriya Thongsomboon, Diego O Serra, Alexandra Possling, Chris Hadjineophytou, Regine Hengge, Lynette Cegelski
Cellulose is a major contributor to the chemical and mechanical properties of plants and assumes structural roles in bacterial communities termed biofilms. We find that Escherichia coli produces chemically modified cellulose that is required for extracellular matrix assembly and biofilm architecture. Solid-state nuclear magnetic resonance spectroscopy of the intact and insoluble material elucidates the zwitterionic phosphoethanolamine modification that had evaded detection by conventional methods. Installation of the phosphoethanolamine group requires BcsG, a proposed phosphoethanolamine transferase, with biofilm-promoting cyclic diguanylate monophosphate input through a BcsE-BcsF-BcsG transmembrane signaling pathway...
January 19, 2018: Science
M M Haque, M M H Oliver, Kamrun Nahar, Mohammad Z Alam, Hisae Hirata, Shinji Tsuyumu
Pectobacterium carotovorum subsp. carotovorum [Pcc (formerly Erwinia carotovora subsp. carotovora)] PC1 causes soft-rot disease in a wide variety of plant species by secreting multiple pathogenicity-related traits. In this study, regulatory mechanism of air-liquid (AL) biofilm formation was studied using a cytR homolog gene deletion mutant (ΔcytR) of Pcc PC1. Compared to the wild type (Pcc PC1), the ΔcytR mutant produced fragile and significantly (P < 0.001) lower amounts of AL biofilm on salt-optimized broth plus 2% glycerol (SOBG), yeast peptone dextrose adenine, and also on King's B at 27°C after 72 h incubation in static condition...
2017: Frontiers in Microbiology
Juliane Becker, Elisabeth Steinmann, Maria Könemann, Sonja Gabske, Hubertus Maximilian Mehdorn, Michael Synowitz, Gesa Hartwigsen, Simone Goebel
This study presents the first validation of the Brief Cognitive Status Exam (BCSE) against two other screening tools for cognitive impairment in patients with intracranial tumors. 58 patients and 22 matched healthy controls completed the BCSE, the Mini Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). Patients were additionally tested with a comprehensive neuropsychological battery. Based on this assessment, they were classified as cognitively impaired or unimpaired on five cognitive domains...
May 2016: Journal of Neuro-oncology
Samuel Justin Sinclair, Julie Walsh-Messinger, Caleb J Siefert, Daniel Antonius, Matthew R Baity, Greg Haggerty, Michelle B Stein, Mark A Blais
Psychologists in medical settings are frequently tasked with providing comprehensive evaluations of patients with complex medical and psychiatric conditions. In order to achieve these aims, standardized measures of neurocognitive and psychological functioning are often employed to empirically assess a patient's level of functioning across an array of relevant clinical domains. However, less is known about the degree to which cognitive impairment affects a patient's ability to complete these more comprehensive assessments, raising questions about test validity...
2015: Bulletin of the Menninger Clinic
H Ozcan, A Yucel, U Z Avşar, E Cankaya, N Yucel, H Gözübüyük, F Eren, M Keles, B Aydınlı
BACKGROUND: Cognitive impairment, anxiety and depression are important problems for patients with chronic kidney failure. Cognitive impairment, anxiety, and depression may be related to various factors, such as complications of hemo/peritoneal dialysis, uremic encephalopathy, psychosocial burden of the disease, and various comorbidities in patients with chronic kidney failure. Successful kidney transplantation (KT) improves kidney, endocrine, metabolic, and vascular systems, mental functions, and the quality of life of the patients...
June 2015: Transplantation Proceedings
Robin C Hilsabeck, James A Holdnack, C Munro Cullum, Lisa Whipple Drozdick, Barry Edelstein, Amy Fiske, Laura Lacritz, Karin J M McCoy, Dustin Wahlstrom
The study purpose was to compare the diagnostic utility of the Brief Cognitive Status Exam (BCSE) to that of the Mini-Mental State Examination (MMSE) and to develop equated scores to facilitate comparisons. One hundred and eighty-two patients underwent cognitive evaluation and were placed into three groups: dementia (DEM), cognitive impairment, no dementia (CIND), and no cognitive impairment (NCI). One hundred and eighty-two healthy controls from the BCSE standardization sample served as a comparison group...
August 2015: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Zita Bouman, Marc P H Hendriks, Albert P Aldenkamp, Roy P C Kessels
ABSTRACT Background: The Brief Cognitive Status Exam (BCSE) is a new, optional subtest of the Wechsler Memory Scale-IV (WMS-IV) developed for rapid detection of cognitive deficits. We examined the clinical validation of the Dutch version of the BCSE in older adults with mild cognitive impairment (MCI) or dementia, comparing it to the Mini-Mental State Examination (MMSE). Method: BCSE and MMSE were administered in 39 older adults with MCI, 51 with dementia and 96 matched healthy controls. Results: Our results show that the BCSE is a valid screening instrument, with psychometric properties similar to the widely used MMSE...
July 31, 2014: International Psychogeriatrics
Xin Fang, Irfan Ahmad, Andrea Blanka, Marco Schottkowski, Annika Cimdins, Michael Y Galperin, Ute Römling, Mark Gomelsky
In contrast to numerous enzymes involved in c-di-GMP synthesis and degradation in enterobacteria, only a handful of c-di-GMP receptors/effectors have been identified. In search of new c-di-GMP receptors, we screened the Escherichia coli ASKA overexpression gene library using the Differential Radial Capillary Action of Ligand Assay (DRaCALA) with fluorescently and radioisotope-labelled c-di-GMP. We uncovered three new candidate c-di-GMP receptors in E. coli and characterized one of them, BcsE. The bcsE gene is encoded in cellulose synthase operons in representatives of Gammaproteobacteria and Betaproteobacteria...
August 2014: Molecular Microbiology
Steffen Fink, Stefanie Mömke, Ottmar Distl
PURPOSE: We performed an association study for bilateral convergent strabismus with exophthalmus (BCSE) in German Brown cattle using single nucleotide polymorphisms (SNPs) located within six positional candidate genes and additional SNPs from bovine SNP databases surrounding these candidate genes. Mutation analyses included synaptotagmin 3 and 5 (SYT3, SYT5), carnitine palmitoyl-transferase 1C (CPT1C) on bovine chromosome 18 (BTA18), and plexin C1 (PLXNC1), intracellular suppressor of cytokine signaling-2 (SOCS2), and kinesin family member 21A (KIF21A) on BTA5...
2012: Molecular Vision
Roslin J Thoppil, Deepak Bhatia, Kendra F Barnes, Erzsebet Haznagy-Radnai, Judit Hohmann, Altaf S Darvesh, Anupam Bishayee
Hepatocellular carcinoma (HCC), considered to be one of the most lethal cancers with almost > 1 million deaths reported annually worldwide, remains a devastating disease with no known effective cure. Hence, chemopreventive strategies come into play, offering an effective and safe mode of treatment, ideal to ward off potential cancer risks and mortality. A major predisposing condition, pertinent to the development and progression of HCC is oxidative stress. We previously reported a striking chemopreventive effect of anthocyanin-rich black currant skin extract (BCSE) against diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats...
November 1, 2012: Current Cancer Drug Targets
Anupam Bishayee, Roslin J Thoppil, Animesh Mandal, Altaf S Darvesh, Vahagn Ohanyan, J Gary Meszaros, Erzsébet Háznagy-Radnai, Judit Hohmann, Deepak Bhatia
Black currant fruits containing high amounts of anthocyanins are known to possess potent antioxidant and anti-inflammatory properties. We have previously reported that anthocyanin-rich black currant skin extract (BCSE) inhibits diethylnitrosamine (DENA)-initiated hepatocarcinogenesis in rats although the underlying mechanisms are not fully understood. Our present study investigates the anti-inflammatory mechanisms of BCSE during DENA rat liver carcinogenesis. Dietary BCSE (100 or 500 mg/kg) treatment for 22 wk afforded a striking inhibition of DENA-induced hepatic gamma-glutamyl transpeptidase-positive preneoplastic foci in a dose-responsive fashion...
April 2013: Molecular Carcinogenesis
Yanna Dou, Li Liu, Xuyang Cheng, Liyun Cao, Li Zuo
BACKGROUND: The accurate assessment of body fluid volume is important in many clinical situations. Hannan et al. proposed a single-frequency bioimpedance equation (HE) to calculate extracellular water (ECW) and total body water (TBW). There are two equations based on the bioimpedance spectroscopy (BIS) method for the evaluation of body fluid volume: Xitron equations (XE) and body composition spectroscopy equations (BCSE). The aim of the study was to compare the accuracy of these three equations in body fluid volume point estimation in maintenance hemodialysis (MHD) patients...
October 2011: Nephrology, Dialysis, Transplantation
O Distl
Data on 10 pedigrees including 184 German Brown Swiss dairy cattle were analysed employing regressive logistic models of segregation analysis. Regarding the ascertainment of the pedigree, dominant Mendelian transmission contributed significantly to the occurrence of BCSE. The segregation analysis showed that a one locus autosomal recessive gene model is not sufficient to explain the observed segregation of BCSE. ZUSAMMENFASSUNG: Analyse von Rinderpedigrees hinsichtlich Segregation von bilateralem Stabismus mit Exophthalmus An 10 Pedigrees mit insgesamt 184 Rindern der Rasse Deutsches Braunvieh wurde anhand von regressiven Modellen der Segregationsanalyse geprüft, ob an dem Auftreten von bilateralem Strabismus convergens mit Exophthalmus ein Einzelgen beteiligt ist...
January 12, 1993: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
Anupam Bishayee, Thomas Mbimba, Roslin J Thoppil, Erzsébet Háznagy-Radnai, Péter Sipos, Altaf S Darvesh, Hans G Folkesson, Judit Hohmann
Anthocyanins are known to possess potent anticarcinogenic properties against several cancers thus demonstrating potential for cancer prevention. Black currant (Ribes nigrum L., Grossulariaceae) fruits have a high anthocyanin content. This "superfruit" is known to possess various pharmacological effects including alleviation of chronic oxidative stress and inflammation. In contrast to a large volume of literature on the health benefits of black currant, limited evidence on antitumor effects of black currant exists with virtually no data on the prevention of experimental carcinogenesis...
November 2011: Journal of Nutritional Biochemistry
S Fink, S Mömke, A Wöhlke, O Distl
PURPOSE: Bilateral convergent strabismus with exophthalmos (BCSE) is a widespread inherited eye defect in several cattle populations. Its progressive condition often leads to blindness in affected cattle and shortens their length of productive life. Furthermore, breeding with BCSE-affected animals is forbidden by the German animal welfare laws. We performed a mutation and association analysis for three candidate genes (troponin T type 1 [TNNT1], retinol dehydrogenase 13 [RDH13], and TCF3 fusion partner [TFPT]), which are located within the previously identified BCSE-linked region on the telomeric end of bovine chromosome 18 (BTA18)...
2008: Molecular Vision
S Mömke, S Fink, A Wöhlke, C Drögemüller, O Distl
Bilateral convergent strabismus with exophthalmus (BCSE) is a widespread inherited eye defect in several cattle populations. Its progressive condition often leads to blindness in affected cattle and decreases their usability. Furthermore, the German animal welfare laws prevent breeding with animals whose progeny are expected to be affected by genetic defects. Identifying genes involved in the heredity of BCSE should lead to insights into the molecular pathogenesis of this eye disease and permit the establishment of a genetic test for this disease...
October 2008: Animal Genetics
E S M Ali, D W O Rogers
This paper presents the implementation of the bremsstrahlung cross-section enhancement (BCSE) variance-reduction technique into the EGSnrc/BEAMnrc system. BCSE makes the simulation of x-ray production from bremsstrahlung targets more efficient; it does so by artificially making the rare event of bremsstrahlung emission more abundant, which increases the number of statistically-independent photons that contribute to reducing the variance of the quantity of interest without increasing the CPU time appreciably...
June 2007: Medical Physics
Mina Tabak, Keren Scher, Efrat Hartog, Ute Romling, Karl R Matthews, Michael L Chikindas, Sima Yaron
Triclosan is a potent biocide that is included in a diverse range of products. This research was aimed to investigate the susceptibility of planktonic and biofilm-associated Salmonella enterica serovar Typhimurium to triclosan, and to identify potential mechanisms of adaptation. The effect of triclosan was studied on planktonic Salmonella (log and stationary phases), on biofilm-associated cells, on bacteria derived from disrupted biofilms and on a biofilm-deficient mutant. An eight-log reduction of exponentially growing cells was observed with 1000 micro g mL(-1) triclosan within 10 min, a 3...
February 2007: FEMS Microbiology Letters
Stefanie Mömke, Ottmar Distl
Bilateral convergent strabismus with exophthalmus (BCSE) is a heritable eye defect prevalent in many cattle breeds and known worldwide. BCSE shows a progressive course often terminating in complete blindness. The onset of the defect can sometimes be slowly progressing (late in life) and, as the first signs of the defect are frequently not noticed prior to first breeding, prevention cannot be achieved only by exclusion of affected animals from the breeding program. This paper provides an overview of the clinical signs, histopathology and genetics of BCSE, its distribution in different cattle breeds and analyses the association between milk production traits and US Brown Swiss...
March 2007: Veterinary Journal
Cristina Solano, Begoña García, Jaione Valle, Carmen Berasain, Jean-Marc Ghigo, Carlos Gamazo, Iñigo Lasa
We report here a new screening method based on the fluorescence of colonies on calcofluor agar plates to identify transposon insertion mutants of Salmonella enteritidis that are defective in biofilm development. The results not only confirmed the requirement of genes already described for the modulation of multicellular behaviour in Salmonella typhimurium and other species, but also revealed new aspects of the biofilm formation process, such as two new genetic elements, named as bcsABZC and bcsEFG operons, required for the synthesis of an exopolysaccharide, digestible with cellulase...
February 2002: Molecular Microbiology
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