Andrey S Kuzovlev, Mikhail D Zybalov, Andrey V Golovin, Maxim A Gureev, Mariia A Kasatkina, Mikhail V Biryukov, Albina R Belik, Sergey A Silonov, Maxim A Yunin, Nailya A Zigangirova, Vasiliy V Reshetnikov, Yulia E Isakova, Yuri B Porozov, Roman A Ivanov
Over the past decades, the problem of bacterial resistance to most antibiotics has become a serious threat to patients' survival. Nevertheless, antibiotics of a novel class have not been approved since the 1980s. The development of antibiotic potentiators is an appealing alternative to the challenging process of searching for new antimicrobials. Production of H2 S-one of the leading defense mechanisms crucial for bacterial survival-can be influenced by the inhibition of relevant enzymes: bacterial cystathionine γ-lyase (bCSE), bacterial cystathionine β-synthase (bCBS), or 3-mercaptopyruvate sulfurtransferase (MST)...
November 15, 2023: International Journal of Molecular Sciences