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https://www.readbyqxmd.com/read/28641352/-do-general-surgeons-feel-adequately-prepared-for-the-complex-questions-associated-with-the-handling-of-multi-resistant-pathogens-results-of-the-mr2-survey
#1
Matthias May, Philipp J Spachmann, Steffen Lebentrau, Harald Schumacher, Christian Gilfrich, Hans-Martin Fritsche, Malte Vetterlein, Sabine Brookman-May, Martin Schostak, Florian M Wagenlehner, Maximilian Burger, Alexander Novotny, Robert Obermaier
Background At the present time, there is no evidence available as to the knowledge of general surgeons regarding multi-resistant pathogens (MRP) and the rational use of antibiotic medication (antibiotic stewardship/ABS) compared with physicians from other disciplines. Methods As part of the MR2 survey (Multiinstitutional Reconnaissance of practice with MultiResistant bacteria - a survey focussing on German hospitals), a questionnaire comprising 4 + 35 items was distributed to urologists, internists, gynaecologists and general surgeons in 18 hospitals...
June 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28641044/the-effects-of-short-versus-long-inter-set-rest-intervals-in-resistance-training-on-measures-of-muscle-hypertrophy-a-systematic-review
#2
Jozo Grgic, Bruno Lazinica, Pavle Mikulic, James W Krieger, Brad Jon Schoenfeld
Although the effects of short versus long inter-set rest intervals in resistance training on measures of muscle hypertrophy have been investigated in several studies, the findings are equivocal and the practical implications remain unclear. In an attempt to provide clarity on the topic, we performed a systematic literature search of PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library, and Physiotherapy Evidence Database (PEDro) electronic databases. Six studies were found to have met the inclusion criteria: (a) an experimental trial published in an English-language peer-reviewed journal; (b) the study compared the use of short (≤60 s) to long (>60 s) inter-set rest intervals in a traditional dynamic resistance exercise using both concentric and eccentric muscle actions, with the only difference in resistance training among groups being the inter-set rest interval duration; (c) at least one method of measuring changes in muscle mass was used in the study; (d) the study lasted for a minimum of four weeks, employed a training frequency of ≥2 resistance training days per week, and (e) used human participants without known chronic disease or injury...
June 22, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28640772/the-effect-of-a-carbohydrate-mouth-rinse-on-upper-body-muscular-strength-and-endurance
#3
James E Dunkin, Shaun M Phillips
Dunkin, JE and Phillips, SM. The effect of a carbohydrate mouth rinse on upper-body muscular strength and endurance. J Strength Cond Res 31(7): 1948-1953, 2017-Carbohydrate (CHO) mouth rinsing rapidly increases corticomotor output and maximal muscle force production, which could enhance muscular strength and endurance during resistance exercise. However, previous research has found no effect of CHO rinsing on muscular strength or endurance. The current study altered the CHO rinse composition and frequency and the muscular endurance test to further investigate the effects of a CHO mouth rinse on upper-body muscular strength and endurance...
July 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28636361/a-machine-learning-assisted-approach-for-discovering-novel-inhibitors-targeting-bromodomain-containing-protein-4
#4
Jing Xing, Wenchao Lu, Rongfeng Liu, Yulan Wang, Yiqian Xie, Hao Zhang, Zhe Shi, Hao Jiang, Yu-Chih Liu, Kaixian Chen, Hualiang Jiang, Cheng Luo, Mingyue Zheng
Bromodomain-containing protein 4 (BRD4) is implicated in the pathogenesis of a number of different cancers, inflammatory diseases and heart failure. Much effort has been dedicated toward discovering novel scaffold BRD4 inhibitors (BRD4is) with different selectivity profiles and potential anti-resistance properties. Structure-based drug design (SBDD) and virtual screening (VS) are the most frequently used approaches. Here, we demonstrate a novel, structure-based VS approach that uses machine-learning algorithms trained on the priori structure and activity knowledge to predict the likelihood that a compound is a BRD4i based on its binding pattern with BRD4...
June 21, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28636204/aerobic-exercise-training-for-adults-with-fibromyalgia
#5
REVIEW
Julia Bidonde, Angela J Busch, Candice L Schachter, Tom J Overend, Soo Y Kim, Suelen M Góes, Catherine Boden, Heather Ja Foulds
BACKGROUND: Exercise training is commonly recommended for individuals with fibromyalgia. This review is one of a series of reviews about exercise training for people with fibromyalgia that will replace the "Exercise for treating fibromyalgia syndrome" review first published in 2002. OBJECTIVES: • To evaluate the benefits and harms of aerobic exercise training for adults with fibromyalgia• To assess the following specific comparisons ० Aerobic versus control conditions (eg, treatment as usual, wait list control, physical activity as usual) ० Aerobic versus aerobic interventions (eg, running vs brisk walking) ० Aerobic versus non-exercise interventions (eg, medications, education) We did not assess specific comparisons involving aerobic exercise versus other exercise interventions (eg, resistance exercise, aquatic exercise, flexibility exercise, mixed exercise)...
June 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28635538/clomipramine-trial-for-treatment-resistant-persistent-genital-arousal-disorder-a-case-series
#6
Ejder Akgun Yildirim, Munevver Hacioglu Yildirim, Elif Carpar, Irmak Sarac
INTRODUCTION: Treatment of persistent genital arousal disorder (PGAD), as a chronic and disabling condition, implicates substantial compelling complexities. METHODS: In this case series, seven women diagnosed with PGAD who were referred to the Sexual Dysfunction Unit of Psychotherapy Outpatient Clinic of Bakirkoy Research and Training Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey between 2006 and 2009 were included. All patients were previously resistant to other antidepressants, antipsychotics and antiepileptics...
March 3, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28635190/characteristics-of-structured-physical-training-currently-provided-in-cardiac-patients-insights-from-the-exercise-training-in-cardiac-rehabilitation-etcr-italian-survey
#7
Marco Ambrosetti, Patrick Doherty, Pompilio Faggiano, Ugo Corrà, Carlo Vigorito, Dominique Hansen, Patrizio Sarto, Ana Abreu, Roberto F E Pedretti
BACKGROUND:   Uncertainty exists about current delivery levels of exercise training (ET) during Cardiac Rehabilitation (CR) programmes. AIM OF THE STUDY: To evaluate ET modalities in the real world of CR facilities in Italy. METHODS: This was an observational survey of aggregate data, collected from CR facilities on a voluntary basis. Snapshots of a single working day at a local site were made, in terms of characteristics of patients and ET programmes delivered...
May 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28633334/knowledge-attitude-and-practice-of-gambian-health-practitioners-towards-antibiotic-prescribing-and-microbiological-testing-a-cross-sectional-survey
#8
Pa Saidou Chaw, Kristin Maria Schlinkmann, Heike Raupach-Rosin, André Karch, Mathias W Pletz, Johannes Huebner, Rafael Mikolajczyk
Background: Inappropriate antibiotic use is the leading cause of antibiotic resistance worldwide. At the same time, the practice of antibiotic prescribing in Africa is less well documented when compared to developed countries. The objective of the study was to assess the knowledge, attitude, and practice (KAP) of health practitioners towards antibiotic prescribing and microbiological testing in The Gambia. Methods: A KAP survey was conducted in The Gambia from March to May 2016...
March 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28633001/impact-of-4-weeks-of-interval-training-on-resting-metabolic-rate-fitness-and-health-related-outcomes
#9
Matthew M Schubert, Holly E Clarke, Rebekah F Seay, Katie K Spain
PURPOSE: Resting metabolic rate (RMR) and substrate oxidation (RER) are important indicators of health. The effects of interval training on RMR have not been thoroughly investigated, which was the purpose of the present study. METHODS: Thirty men and women (mean ± SD age and VO2max: 28.8 ± 7.6 yrs and 33.0 ± 8.3 mL∙kg-1∙min-1) completed 4 weeks of Wingate-based sprint interval training (SIT), repeated 1-minute high-intensity intervals (HIIT), or served as controls (CON)...
June 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28632046/targeting-associated-mechanisms-of-anterior-cruciate-ligament-injury-in-female-community-level-athletes
#10
Jonathan M D Staynor, Joanna C Nicholas, Gillian Weir, Jacqueline A Alderson, Cyril J Donnelly
This study aims to determine if biomechanically informed injury prevention training can reduce associated factors of anterior cruciate ligament injury risk among a general female athletic population. Female community-level team sport athletes, split into intervention (n = 8) and comparison groups (n = 10), completed a sidestepping movement assessment prior to and following a 9-week training period, in which kinetic, kinematic and neuromuscular data were collected. The intervention group completed a biomechanically informed training protocol, consisting of plyometric, resistance and balance exercises, adjunct to normal training, for 15-20 min twice a week...
February 24, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28630601/international-society-of-sports-nutrition-position-stand-diets-and-body-composition
#11
REVIEW
Alan A Aragon, Brad J Schoenfeld, Robert Wildman, Susan Kleiner, Trisha VanDusseldorp, Lem Taylor, Conrad P Earnest, Paul J Arciero, Colin Wilborn, Douglas S Kalman, Jeffrey R Stout, Darryn S Willoughby, Bill Campbell, Shawn M Arent, Laurent Bannock, Abbie E Smith-Ryan, Jose Antonio
Position Statement: The International Society of Sports Nutrition (ISSN) bases the following position stand on a critical analysis of the literature regarding the effects of diet types (macronutrient composition; eating styles) and their influence on body composition. The ISSN has concluded the following. 1) There is a multitude of diet types and eating styles, whereby numerous subtypes fall under each major dietary archetype. 2) All body composition assessment methods have strengths and limitations. 3) Diets primarily focused on fat loss are driven by a sustained caloric deficit...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28630577/effects-of-high-velocity-elastic-band-versus-heavy-resistance-training-on-hamstring-strength-activation-and-sprint-running-performance
#12
Donatas Janusevicius, Audrius Snieckus, Albertas Skurvydas, Viktoras Silinskas, Eugenijus Trinkunas, Joan Aureli Cadefau, Sigitas Kamandulis
Hamstring muscle injuries occur during high-speed activities, which suggests that muscular strength at high velocities may be more important than maximal strength. This study examined hamstring adaptations to training for maximal strength and for strength at high velocities. Physically active men (n = 25; age, 23.0 ± 3.2 years) were randomly divided into: (1) a resistance training (RT, n = 8) group, which performed high-load, low-velocity concentric-eccentric hamstring contractions; (2) a resistance training concentric (RTC; n = 9) group, which performed high-load, low-velocity concentric-only hamstring contractions; and (3) a high-velocity elastic band training (HVT, n = 8) group, which performed low-load, high-velocity concentric-eccentric hamstring contractions...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28630576/no-effect-of-a-whey-growth-factor-extract-during-resistance-training-on-strength-body-composition-or-hypertrophic-gene-expression-in-resistance-trained-young-men
#13
Michael J Dale, Alison M Coates, Peter R C Howe, Grant R Tomkinson, Matthew T Haren, Andrew Brown, Marissa Caldow, David Cameron-Smith, Jonathan D Buckley
Growth factors can be isolated from bovine milk to form a whey growth factor extract (WGFE). This study examined whether WGFE promoted activation of the AKT/mTOR pathway enabling increased lean tissue mass and strength in resistance trained men. Forty six men with >6 months of resistance training (RT) experience performed 12 weeks of RT. Participants consumed 20 g/day of whey protein and were randomised to receive either 1.6 g WGFE/day (WGFE; n = 22) or 1.6 g cellulose/day (control, CONT; n = 24). The primary outcome was leg press one-repetition maximum (LP1-RM) which was assessed at baseline, 6 and 12 weeks...
June 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28629754/improving-compliance-with-surgical-antibiotic-prophylaxis-guidelines-a-multicenter-evaluation
#14
Cristiane Schmitt, Rubia Aparecida Lacerda, Ruth Natalia Teresa Turrini, Maria Clara Padoveze
BACKGROUND: Improving surgical antibiotic prophylaxis (SAP) use is an important element in the control of antimicrobial resistance. However, compliance with SAP guidelines is unsatisfactory. This study investigated the level of compliance with SAP guidelines in neurosurgery, and institutional characteristics associated with compliance. METHODS: This study assessed surgeries in 9 Brazilian hospitals. Medical record reviews and a structured questionnaire were used to assess compliance and to describe institutional characteristics...
June 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28628370/multiple-joint-exercises-using-elastic-resistance-bands-vs-conventional-resistance-training-equipment-a-cross-over-study
#15
Vegard M Iversen, Paul Jarle Mork, Ottar Vasseljen, Ronny Bergquist, Marius S Fimland
Previous studies indicate that elastic resistance bands (ERB) can be a viable option to conventional resistance-training equipment (CRE) during single-joint resistance exercises, but their efficacy has not been established for several commonly used multiple-joint resistance exercises. Thus, we compared muscular activation levels in four popular multiple-joint exercises performed with ERB (TheraBand(®)) vs. CRE (Olympic barbell or cable pulley machines). In a cross-over design, men and women (n = 29) performed squats, stiff-legged deadlifts, unilateral rows and lateral pulldown using both modalities...
June 19, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28628245/effects-of-resistance-training-using-known-vs-unknown-loads-on-eccentric-phase-adaptations-and-concentric-velocity
#16
Jose Luis Hernández-Davó, Rafael Sabido, David G Behm, Anthony J Blazevich
The aims of this study were to compare both eccentric- and concentric-phase adaptations in highly-trained handball players to 4 weeks of twice-weekly rebound bench press throw training with varying loads (30%, 50% and 70% of 1-repetition maximum [1-RM]) using either known (KL) or unknown (UL) loads, and to examine the relationship between changes in eccentric- and concentric-phase performance. Twenty-eight junior team-handball players were divided into two experimental groups (KL or UL) and a control group...
June 19, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28628064/exercise-training-reduces-intrathoracic-fat-regardless-of-defective-glucose-tolerance
#17
Sanna M Honkala, Kumail K Motiani, Jari-Joonas Eskelinen, Anna Savolainen, Virva Saunavaara, Kirsi A Virtanen, Eliisa Löyttyniemi, Jukka Kapanen, Juhani Knuuti, Kari K Kalliokoski, Jarna C Hannukainen
PURPOSE: Epicardial (EAT) and pericardial (PAT) fat masses and myocardial triglyceride content (MTC) are enlarged in obesity and insulin resistance. We studied whether the high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) similarly decrease ectopic fat in and around the heart and whether the decrease is similar in healthy subjects and subjects with defective glucose tolerance (DGT). METHODS: A total of 28 healthy men (body mass index = 20...
July 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28626972/nirca-an-artificial-neural-network-based-insulin-resistance-calculator
#18
Konrad Stawiski, Iwona Pietrzak, Wojciech Młynarski, Wojciech Fendler, Agnieszka Szadkowska
BACKGROUND: Direct measurement of insulin sensitivity in children with type 1 diabetes is cumbersome and time consuming. OBJECTIVE: The aim of our study was to develop novel, accurate machine learning-based methods of insulin resistance estimation in children with type 1 diabetes. METHODS: A hyperinsulinemic hyperglycemic clamp study was performed to evaluate the glucose disposal rate (GDR) in a study group consisting of 315 patients aged 7...
June 19, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28626322/the-effect-of-age-on-hamstring-passive-properties-after-a-10-week-stretch-training
#19
Thomas Haab, Georg Wydra
[Purpose] Degenerative changes take place in the musculoskeletal system of elderly people, resulting in a reduced range of motion. For this reason, stretch training is recommended for elderly individuals. To date, there have been no studies of the adaptations of the passive properties of muscles following long-term stretch training. The aim of this study is to investigate the hamstring elasticity of elderly people following a 10-week stretch training and compare the results to a younger cohort. [Subjects and Methods] The experimental groups consisted of 15 younger (24...
June 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28623895/effects-of-home-based-exercise-on-pre-dialysis-chronic-kidney-disease-patients-a-randomized-pilot-and-feasibility-trial
#20
Koji Hiraki, Yugo Shibagaki, Kazuhiro P Izawa, Chiharu Hotta, Akiko Wakamiya, Tsutomu Sakurada, Takashi Yasuda, Kenjiro Kimura
BACKGROUND: Only a few research is available on the effects of home-based exercise training on pre-dialysis chronic kidney disease (CKD) patients. Therefore, we aimed to elucidate the effect of home-based exercise therapy on kidney function and arm and leg muscle strength in pre-dialysis CKD patients. METHODS: Thirty-six male stage 3-4 pre-dialysis CKD patients (age, 68.7 ± 6.8 years; estimated glomerular filtration rate (eGFR), 39.0 ± 11.6 ml/min/1.73 m(2)) who were being treated as outpatients were included...
June 17, 2017: BMC Nephrology
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